Serum tolerance and endosomal escape capacity of histidine-modified pDNA-loaded complexes based on polyamidoamine dendrimer derivatives

Biomaterials

Volumn 33, Issue 32, 2012, Pages 8111-8121

  Wen, Yuting ^a   Guo, Zhenhuan ^a   Du, Zhuo ^b   Fang, Rong ^a   Wu, Hongmei ^a   Zeng, Xin ^a   Wang, Chi ^a   Feng, Min ^a   Pan, Shirong ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b FOSHAN UNIVERSITY   (China)

Author keywords

Endosomal escape; Gene delivery; Histidine; Polyamidoamine; Serum tolerance

Indexed keywords

AMINOLYSIS REACTION; CELLULAR UPTAKE; CONFOCAL MICROSCOPES; ENDOSOMAL ESCAPE; ENDOSOMES; ESCAPE MECHANISM; GENE DELIVERY; GENE TRANSFECTION; H NMR SPECTRA; HISTIDINE; MALDI TOF MS; POLYAMIDOAMINE DENDRIMERS; POLYAMIDOAMINES; PROTEIN EXPRESSION LEVELS; PROTON PUMP; SERUM CONCENTRATION; TRANSFECTION EFFICIENCY;

AMINO ACIDS; CYTOTOXICITY; DENDRIMERS; FLOW CYTOMETRY; GENE TRANSFER; GENES; MOLECULAR BIOLOGY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

BODY FLUIDS;

DENDRIMER; DNA; HISTIDINE ACTIVATED PAMAM GENERATION 4; LUCIFERASE; PAMAM GENERATION 4; POLYAMIDOAMINE; POLYETHYLENEIMINE; POLYMER; PROTON PUMP; STARBURST; SUPERFECT; UNCLASSIFIED DRUG;

AMINOLYSIS; ARTICLE; COMPLEX FORMATION; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG SYNTHESIS; ENDOSOME; FLOW CYTOMETRY; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LYSOSOME; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NONVIRAL GENE DELIVERY SYSTEM; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTON NUCLEAR MAGNETIC RESONANCE; QUANTITATIVE ANALYSIS; SERUM;

ANIMALS; CELL LINE, TUMOR; CELL SURVIVAL; DENDRIMERS; DNA; ENDOSOMES; FEMALE; HISTIDINE; HUMANS; LUCIFERASES, RENILLA; PLASMIDS; POLYAMINES; RENILLA; SERUM; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TRANSFECTION;

EID: 84865540257     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2012.07.032     Document Type: Article

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