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Volumn 36, Issue 2, 2017, Pages 115-134

Mass spectrometric based approaches in urine metabolomics and biomarker discovery

Author keywords

Biomarker; Mass Spectrometry; Metabolome; Targeted; Untargeted; Urine

Indexed keywords

BIOMARKERS; BODY FLUIDS; CAPILLARY ELECTROPHORESIS; CHEMICAL ANALYSIS; CHROMATOGRAPHY; DIAGNOSIS; DIRECT INJECTION; EXTRACTION; FILTRATION; GAS CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROPHILICITY; ISOTOPES; LIQUIDS; MASS SPECTROMETRY; METABOLITES; SOLVENT EXTRACTION; SPECTROMETRY;

EID: 84927932397     PISSN: 02777037     EISSN: 10982787     Source Type: Journal    
DOI: 10.1002/mas.21455     Document Type: Review
Times cited : (245)

References (160)
  • 2
    • 84858702392 scopus 로고    scopus 로고
    • Comprehensive two-dimensional gas chromatography in metabolomics
    • Almstetter MF, Oefner PJ, Dettmer K. 2012. Comprehensive two-dimensional gas chromatography in metabolomics. Anal Bioanal Chem 402: 1993–2013.
    • (2012) Anal Bioanal Chem , vol.402 , pp. 1993-2013
    • Almstetter, M.F.1    Oefner, P.J.2    Dettmer, K.3
  • 3
    • 84889591862 scopus 로고    scopus 로고
    • Metabolomics in cancer biomarker discovery: Current trends and future perspectives
    • Armitage EG, Barbas C. 2014. Metabolomics in cancer biomarker discovery: Current trends and future perspectives. J Pharm Biomed Anal 87:1–11.
    • (2014) J Pharm Biomed Anal , vol.87 , pp. 1-11
    • Armitage, E.G.1    Barbas, C.2
  • 4
    • 0035026145 scopus 로고    scopus 로고
    • Recent advances in capillary electrophoresis/electrospray-mass spectrometry
    • Bayer E. 2001. Recent advances in capillary electrophoresis/electrospray-mass spectrometry. Electrophoresis 22:1251–1266.
    • (2001) Electrophoresis , vol.22 , pp. 1251-1266
    • Bayer, E.1
  • 5
    • 76749088424 scopus 로고    scopus 로고
    • Liquid chromatography–tandem mass spectrometry for the determination of low-molecular mass aldehydes in human urine
    • Baños CE, Silva M. 2010. Liquid chromatography–tandem mass spectrometry for the determination of low-molecular mass aldehydes in human urine. J Chromatogr B 878: 653–658.
    • (2010) J Chromatogr B , vol.878 , pp. 653-658
    • Baños, C.E.1    Silva, M.2
  • 7
    • 68849116797 scopus 로고    scopus 로고
    • Development and Performance of a Gas Chromatography − Time-of-Flight Mass Spectrometry Analysis for Large-Scale Nontargeted Metabolomic Studies of Human Serum
    • Begley P, Francis-McIntyre S, Dunn WB, Broadhurst DI, Halsall A, Tseng A, Knowles J, Consortium H, Goodacre R, Kell DB. 2009. Development and Performance of a Gas Chromatography − Time-of-Flight Mass Spectrometry Analysis for Large-Scale Nontargeted Metabolomic Studies of Human Serum. Anal Chem 81: 7038–7046.
    • (2009) Anal Chem , vol.81 , pp. 7038-7046
    • Begley, P.1    Francis-McIntyre, S.2    Dunn, W.B.3    Broadhurst, D.I.4    Halsall, A.5    Tseng, A.6    Knowles, J.7    Consortium, H.8    Goodacre, R.9    Kell, D.B.10
  • 8
    • 79958771235 scopus 로고    scopus 로고
    • Standard operating procedures for pre-analytical handling of blood and urine for metabolomic studies and biobanks
    • Bernini P, Bertini I, Luchinat C, Nincheri P, Staderini S, Turano P. 2011. Standard operating procedures for pre-analytical handling of blood and urine for metabolomic studies and biobanks. J Biomol NMR 49: 231–243.
    • (2011) J Biomol NMR , vol.49 , pp. 231-243
    • Bernini, P.1    Bertini, I.2    Luchinat, C.3    Nincheri, P.4    Staderini, S.5    Turano, P.6
  • 9
    • 27144452266 scopus 로고    scopus 로고
    • A case study of acute human chlorpyrifos poisoning: Novel aspects on metabolism and toxicokinetics derived from liquid chromatography–tandem mass spectrometry analysis of urine samples
    • Bicker W, Lämmerhofer M, Genser D, Kiss H, Lindner W. 2005. A case study of acute human chlorpyrifos poisoning: Novel aspects on metabolism and toxicokinetics derived from liquid chromatography–tandem mass spectrometry analysis of urine samples. Toxicol lett 159: 235–251.
    • (2005) Toxicol lett , vol.159 , pp. 235-251
    • Bicker, W.1    Lämmerhofer, M.2    Genser, D.3    Kiss, H.4    Lindner, W.5
  • 10
    • 0027496681 scopus 로고
    • Interpretation of urine results used to assess chemical exposure with emphasis on creatinine adjustments: A review
    • Boeniger MF, Lowry LK, Rosenberg J. 1993. Interpretation of urine results used to assess chemical exposure with emphasis on creatinine adjustments: A review. Am Ind Hyg Assoc J 54: 615–627.
    • (1993) Am Ind Hyg Assoc J , vol.54 , pp. 615-627
    • Boeniger, M.F.1    Lowry, L.K.2    Rosenberg, J.3
  • 11
    • 84875051992 scopus 로고    scopus 로고
    • UPLC-QTOF/MS metabolic profiling unveils urinary changes in humans after a whole grain rye versus refined wheat bread intervention
    • Bondia-Pons I, Barri T, Hanhineva K, Juntunen K, Dragsted LO, Mykkänen H, Poutanen K. 2013. UPLC-QTOF/MS metabolic profiling unveils urinary changes in humans after a whole grain rye versus refined wheat bread intervention. Mol Nutr Food Res 57: 412–422.
    • (2013) Mol Nutr Food Res , vol.57 , pp. 412-422
    • Bondia-Pons, I.1    Barri, T.2    Hanhineva, K.3    Juntunen, K.4    Dragsted, L.O.5    Mykkänen, H.6    Poutanen, K.7
  • 12
    • 0027765639 scopus 로고
    • Optimal collection and storage conditions for catecholamine measurements in human plasma and urine
    • Boomsma F, Alberts G, Van Eijk L, Schalekamp M. 1993. Optimal collection and storage conditions for catecholamine measurements in human plasma and urine. Clin Chem 39: 2503–2508.
    • (1993) Clin Chem , vol.39 , pp. 2503-2508
    • Boomsma, F.1    Alberts, G.2    Van Eijk, L.3    Schalekamp, M.4
  • 15
    • 78651029284 scopus 로고
    • The activity of the enzymes sulphatase and β-glucuronidase in the urine, serum and bladder tissue
    • Boyland E, Wallace D, Williams D. 1955. The activity of the enzymes sulphatase and β-glucuronidase in the urine, serum and bladder tissue. Br J cancer 9: 62.
    • (1955) Br J cancer , vol.9 , pp. 62
    • Boyland, E.1    Wallace, D.2    Williams, D.3
  • 16
    • 84856216972 scopus 로고    scopus 로고
    • Hydrophilic interaction liquid chromatography (HILIC)—a powerful separation technique
    • Buszewski B, Noga S. 2012. Hydrophilic interaction liquid chromatography (HILIC)—a powerful separation technique. Anal Bioanal Chem 402: 231–247.
    • (2012) Anal Bioanal Chem , vol.402 , pp. 231-247
    • Buszewski, B.1    Noga, S.2
  • 17
    • 0035063590 scopus 로고    scopus 로고
    • Measurement of urinary concentration: a critical appraisal of methodologies
    • Chadha V, Garg U, Alon US. 2001. Measurement of urinary concentration: a critical appraisal of methodologies. Pediatr Nephrol 16: 374–382.
    • (2001) Pediatr Nephrol , vol.16 , pp. 374-382
    • Chadha, V.1    Garg, U.2    Alon, U.S.3
  • 18
    • 69249140995 scopus 로고    scopus 로고
    • Metabonomics study of liver cancer based on ultra performance liquid chromatography coupled to mass spectrometry with HILIC and RPLC separations
    • Chen J, Wang W, Lv S, Yin P, Zhao X, Lu X, Zhang F, Xu G. 2009. Metabonomics study of liver cancer based on ultra performance liquid chromatography coupled to mass spectrometry with HILIC and RPLC separations. Anal Chim Acta 650: 3–9.
    • (2009) Anal Chim Acta , vol.650 , pp. 3-9
    • Chen, J.1    Wang, W.2    Lv, S.3    Yin, P.4    Zhao, X.5    Lu, X.6    Zhang, F.7    Xu, G.8
  • 19
    • 80053593178 scopus 로고    scopus 로고
    • Determination of urinary malondialdehyde by isotope dilution LC-MS/MS with automated solid-phase extraction: a cautionary note on derivatization optimization
    • Chen J-L, Huang Y-J, Pan C-H, Hu C-W, Chao M-R. 2011a. Determination of urinary malondialdehyde by isotope dilution LC-MS/MS with automated solid-phase extraction: a cautionary note on derivatization optimization. Free Radical Biol Med 51: 1823–1829.
    • (2011) Free Radical Biol Med , vol.51 , pp. 1823-1829
    • Chen, J.-L.1    Huang, Y.-J.2    Pan, C.-H.3    Hu, C.-W.4    Chao, M.-R.5
  • 20
    • 84855206110 scopus 로고    scopus 로고
    • Serum and urine metabolite profiling reveals potential biomarkers of human hepatocellular carcinoma
    • M110. 004945
    • Chen T, Xie G, Wang X, Fan J, Qiu Y, Zheng X, Qi X, Cao Y, Su M, Wang X. 2011b. Serum and urine metabolite profiling reveals potential biomarkers of human hepatocellular carcinoma. Mol Cell Proteomics 10: M110. 004945.
    • (2011) Mol Cell Proteomics , vol.10
    • Chen, T.1    Xie, G.2    Wang, X.3    Fan, J.4    Qiu, Y.5    Zheng, X.6    Qi, X.7    Cao, Y.8    Su, M.9    Wang, X.10
  • 21
    • 61849178717 scopus 로고    scopus 로고
    • Evaluation of urinary nucleosides in breast cancer patients before and after tumor removal
    • Cho S-H, Choi MH, Lee W-Y, Chung BC. 2009. Evaluation of urinary nucleosides in breast cancer patients before and after tumor removal. Clin Biochem 42: 540–543.
    • (2009) Clin Biochem , vol.42 , pp. 540-543
    • Cho, S.-H.1    Choi, M.H.2    Lee, W.-Y.3    Chung, B.C.4
  • 22
    • 0036807910 scopus 로고    scopus 로고
    • Measurement of intact sulfate and glucuronide phytoestrogen conjugates in human urine using isotope dilution liquid chromatography-tandem mass spectrometry with [13C3] isoflavone internal standards
    • Clarke DB, Lloyd AS, Botting NP, Oldfield MF, Needs PW, Wiseman H. 2002. Measurement of intact sulfate and glucuronide phytoestrogen conjugates in human urine using isotope dilution liquid chromatography-tandem mass spectrometry with [13C3] isoflavone internal standards. Anal Biochem 309: 158–172.
    • (2002) Anal Biochem , vol.309 , pp. 158-172
    • Clarke, D.B.1    Lloyd, A.S.2    Botting, N.P.3    Oldfield, M.F.4    Needs, P.W.5    Wiseman, H.6
  • 24
    • 84870502195 scopus 로고    scopus 로고
    • Comprehensive and highly sensitive urinary steroid hormone profiling method based on stable isotope-labeling liquid chromatography–mass spectrometry
    • Dai W, Huang Q, Yin P, Li J, Zhou J, Kong H, Zhao C, Lu X, Xu G. 2012. Comprehensive and highly sensitive urinary steroid hormone profiling method based on stable isotope-labeling liquid chromatography–mass spectrometry. Anal Chem 84: 10245–10251.
    • (2012) Anal Chem , vol.84 , pp. 10245-10251
    • Dai, W.1    Huang, Q.2    Yin, P.3    Li, J.4    Zhou, J.5    Kong, H.6    Zhao, C.7    Lu, X.8    Xu, G.9
  • 26
    • 42449122308 scopus 로고    scopus 로고
    • Current trends and future requirements for the mass spectrometric investigation of microbial, mammalian and plant metabolomes
    • Dunn WB. 2008. Current trends and future requirements for the mass spectrometric investigation of microbial, mammalian and plant metabolomes. Phys biol 5: 011001.
    • (2008) Phys biol , vol.5 , pp. 011001
    • Dunn, W.B.1
  • 28
    • 78650315006 scopus 로고    scopus 로고
    • Systems level studies of mammalian metabolomes: the roles of mass spectrometry and nuclear magnetic resonance spectroscopy
    • Dunn WB, Broadhurst DI, Atherton HJ, Goodacre R, Griffin JL. 2011. Systems level studies of mammalian metabolomes: the roles of mass spectrometry and nuclear magnetic resonance spectroscopy. Chem Soc Rev 40: 387–426.
    • (2011) Chem Soc Rev , vol.40 , pp. 387-426
    • Dunn, W.B.1    Broadhurst, D.I.2    Atherton, H.J.3    Goodacre, R.4    Griffin, J.L.5
  • 29
    • 16244402990 scopus 로고    scopus 로고
    • Metabolomics: current analytical platforms and methodologies. TrAC
    • Dunn WB, Ellis DI. 2005. Metabolomics: current analytical platforms and methodologies. TrAC. Trends Anal Chem 24: 285–294.
    • (2005) Trends Anal Chem , vol.24 , pp. 285-294
    • Dunn, W.B.1    Ellis, D.I.2
  • 31
    • 57449093131 scopus 로고    scopus 로고
    • Development of a selective ESI-MS derivatization reagent: synthesis and optimization for the analysis of aldehydes in biological mixtures
    • Eggink M, Wijtmans M, Ekkebus R, Lingeman H, de Esch IJP, Kool J, Niessen WM, Irth H. 2008. Development of a selective ESI-MS derivatization reagent: synthesis and optimization for the analysis of aldehydes in biological mixtures. Anal chem 80: 9042–9051.
    • (2008) Anal chem , vol.80 , pp. 9042-9051
    • Eggink, M.1    Wijtmans, M.2    Ekkebus, R.3    Lingeman, H.4    de Esch, I.J.P.5    Kool, J.6    Niessen, W.M.7    Irth, H.8
  • 33
    • 84869195682 scopus 로고    scopus 로고
    • Preparation of urine samples prior to targeted or untargeted metabolomics mass-spectrometry analysis. TrAC
    • Fernández-Peralbo M, Luque de Castro M. 2012. Preparation of urine samples prior to targeted or untargeted metabolomics mass-spectrometry analysis. TrAC. Trends Anal Chem 41:75–85.
    • (2012) Trends Anal Chem , vol.41 , pp. 75-85
    • Fernández-Peralbo, M.1    Luque de Castro, M.2
  • 36
    • 0035577942 scopus 로고    scopus 로고
    • Reduction of signal suppression effects in ESI-MS using a nanosplitting device
    • Gangl ET, Annan M, Spooner N, Vouros P. 2001. Reduction of signal suppression effects in ESI-MS using a nanosplitting device. Anal chem 73: 5635–5644.
    • (2001) Anal chem , vol.73 , pp. 5635-5644
    • Gangl, E.T.1    Annan, M.2    Spooner, N.3    Vouros, P.4
  • 37
    • 45949087351 scopus 로고    scopus 로고
    • Hydrophilic interaction and reversed-phase ultra-performance liquid chromatography TOF-MS for metabonomic analysis of Zucker rat urine
    • Gika HG, Theodoridis GA, Wilson ID. 2008a. Hydrophilic interaction and reversed-phase ultra-performance liquid chromatography TOF-MS for metabonomic analysis of Zucker rat urine. J Sep Sci 31: 1598–1608.
    • (2008) J Sep Sci , vol.31 , pp. 1598-1608
    • Gika, H.G.1    Theodoridis, G.A.2    Wilson, I.D.3
  • 38
    • 41949086183 scopus 로고    scopus 로고
    • Liquid chromatography and ultra-performance liquid chromatography–mass spectrometry fingerprinting of human urine: Sample stability under different handling and storage conditions for metabonomics studies
    • Gika HG, Theodoridis GA, Wilson ID. 2008b. Liquid chromatography and ultra-performance liquid chromatography–mass spectrometry fingerprinting of human urine: Sample stability under different handling and storage conditions for metabonomics studies. J Chromatogr A 1189: 314–322.
    • (2008) J Chromatogr A , vol.1189 , pp. 314-322
    • Gika, H.G.1    Theodoridis, G.A.2    Wilson, I.D.3
  • 41
    • 84863456541 scopus 로고    scopus 로고
    • Liquid chromatography-mass spectrometric multiple reaction monitoring-based strategies for expanding targeted profiling towards quantitative metabolomics
    • Guo B, Chen B, Liu A, Zhu W, Yao S. 2012. Liquid chromatography-mass spectrometric multiple reaction monitoring-based strategies for expanding targeted profiling towards quantitative metabolomics. Curr Drug Metab 13: 1226–1243.
    • (2012) Curr Drug Metab , vol.13 , pp. 1226-1243
    • Guo, B.1    Chen, B.2    Liu, A.3    Zhu, W.4    Yao, S.5
  • 42
    • 36448966459 scopus 로고    scopus 로고
    • Stable-isotope dimethylation labeling combined with LC-ESI MS for quantification of amine-containing metabolites in biological samples
    • Guo K, Ji C, Li L. 2007. Stable-isotope dimethylation labeling combined with LC-ESI MS for quantification of amine-containing metabolites in biological samples. Anal chem 79: 8631–8638.
    • (2007) Anal chem , vol.79 , pp. 8631-8638
    • Guo, K.1    Ji, C.2    Li, L.3
  • 43
    • 66149094266 scopus 로고    scopus 로고
    • Differential 12C-/13C-isotope dansylation labeling and fast liquid chromatography/mass spectrometry for absolute and relative quantification of the metabolome
    • Guo K, Li L. 2009. Differential 12C-/13C-isotope dansylation labeling and fast liquid chromatography/mass spectrometry for absolute and relative quantification of the metabolome. Anal chem 81: 3919–3932.
    • (2009) Anal chem , vol.81 , pp. 3919-3932
    • Guo, K.1    Li, L.2
  • 44
    • 78049517394 scopus 로고    scopus 로고
    • High-performance isotope labeling for profiling carboxylic acid-containing metabolites in biofluids by mass spectrometry
    • Guo K, Li L. 2010. High-performance isotope labeling for profiling carboxylic acid-containing metabolites in biofluids by mass spectrometry. Anal chem 82: 8789–8793.
    • (2010) Anal chem , vol.82 , pp. 8789-8793
    • Guo, K.1    Li, L.2
  • 45
  • 47
    • 34548618455 scopus 로고    scopus 로고
    • Urinary metabolic fingerprinting for amiodarone-induced phospholipidosis in rats using FT-ICR MS
    • Hasegawa M, Takenaka S, Kuwamura M, Yamate J, Tsuyama S. 2007. Urinary metabolic fingerprinting for amiodarone-induced phospholipidosis in rats using FT-ICR MS. Exp Toxicol Pathol 59: 115–120.
    • (2007) Exp Toxicol Pathol , vol.59 , pp. 115-120
    • Hasegawa, M.1    Takenaka, S.2    Kuwamura, M.3    Yamate, J.4    Tsuyama, S.5
  • 48
    • 77956831582 scopus 로고    scopus 로고
    • Fluorous derivatization combined with liquid chromatography/tandem mass spectrometry: a method for the selective and sensitive determination of sialic acids in biological samples
    • Hayama T, Sakaguchi Y, Yoshida H, Itoyama M, Todoroki K, Yamaguchi M, Nohta H. 2010. Fluorous derivatization combined with liquid chromatography/tandem mass spectrometry: a method for the selective and sensitive determination of sialic acids in biological samples. Rapid Commun Mass Spectrom 24: 2868–2874.
    • (2010) Rapid Commun Mass Spectrom , vol.24 , pp. 2868-2874
    • Hayama, T.1    Sakaguchi, Y.2    Yoshida, H.3    Itoyama, M.4    Todoroki, K.5    Yamaguchi, M.6    Nohta, H.7
  • 49
    • 32944469912 scopus 로고    scopus 로고
    • Effect of creatinine and specific gravity normalization techniques on xenobiotic biomarkers in smokers' spot and 24-h urines
    • Heavner DL, Morgan WT, Sears SB, Richardson JD, Byrd GD, Ogden MW. 2006. Effect of creatinine and specific gravity normalization techniques on xenobiotic biomarkers in smokers' spot and 24-h urines. J Pharm Biomed Anal 40: 928–942.
    • (2006) J Pharm Biomed Anal , vol.40 , pp. 928-942
    • Heavner, D.L.1    Morgan, W.T.2    Sears, S.B.3    Richardson, J.D.4    Byrd, G.D.5    Ogden, M.W.6
  • 51
    • 67349179176 scopus 로고    scopus 로고
    • An approach for the development and selection of chromatographic methods for high-throughput metabolomic screening of urine by ultra pressure LC-ESI-ToF-MS
    • Hodson MP, Dear GJ, Griffin JL, Haselden JN. 2009. An approach for the development and selection of chromatographic methods for high-throughput metabolomic screening of urine by ultra pressure LC-ESI-ToF-MS. Metabolomics 5: 166–182.
    • (2009) Metabolomics , vol.5 , pp. 166-182
    • Hodson, M.P.1    Dear, G.J.2    Griffin, J.L.3    Haselden, J.N.4
  • 53
    • 79960651478 scopus 로고    scopus 로고
    • Analysis of urinary nucleosides as potential tumor markers in human breast cancer by high performance liquid chromatography/electrospray ionization tandem mass spectrometry
    • Hsu W-Y, Lin W-D, Tsai Y, Lin C-T, Wang H-C, Jeng L-B, Lee C-C, Lin Y-C, Lai C-C, Tsai F-J. 2011. Analysis of urinary nucleosides as potential tumor markers in human breast cancer by high performance liquid chromatography/electrospray ionization tandem mass spectrometry. Clin Chim Acta 412: 1861–1866.
    • (2011) Clin Chim Acta , vol.412 , pp. 1861-1866
    • Hsu, W.-Y.1    Lin, W.-D.2    Tsai, Y.3    Lin, C.-T.4    Wang, H.-C.5    Jeng, L.-B.6    Lee, C.-C.7    Lin, Y.-C.8    Lai, C.-C.9    Tsai, F.-J.10
  • 56
    • 0037109053 scopus 로고    scopus 로고
    • Determination of 4-hydroxy-3-methoxyphenylethylene glycol 4-sulfate in human urine using liquid chromatography-tandem mass spectrometry
    • Jacob P, Wilson M, Yu L, Mendelson J, Jones RT. 2002. Determination of 4-hydroxy-3-methoxyphenylethylene glycol 4-sulfate in human urine using liquid chromatography-tandem mass spectrometry. Anal chem 74: 5290–5296.
    • (2002) Anal chem , vol.74 , pp. 5290-5296
    • Jacob, P.1    Wilson, M.2    Yu, L.3    Mendelson, J.4    Jones, R.T.5
  • 59
    • 84858730393 scopus 로고    scopus 로고
    • Challenges and opportunities of metabolomics
    • Johnson CH, Gonzalez FJ. 2012. Challenges and opportunities of metabolomics. J Cell Physiol 227: 2975–2981.
    • (2012) J Cell Physiol , vol.227 , pp. 2975-2981
    • Johnson, C.H.1    Gonzalez, F.J.2
  • 60
    • 0020711019 scopus 로고
    • Particulate and free enzyme activity in urine as a result of the shedding of brush-border membranes from kidney
    • Jung K, Pergande M. 1983. Particulate and free enzyme activity in urine as a result of the shedding of brush-border membranes from kidney. Clin Chim 29: 392–393.
    • (1983) Clin Chim , vol.29 , pp. 392-393
    • Jung, K.1    Pergande, M.2
  • 61
    • 34347405493 scopus 로고    scopus 로고
    • Data processing for mass spectrometry-based metabolomics
    • Katajamaa M, Orešič M. 2007. Data processing for mass spectrometry-based metabolomics. J Chromatogr A 1158: 318–328.
    • (2007) J Chromatogr A , vol.1158 , pp. 318-328
    • Katajamaa, M.1    Orešič, M.2
  • 62
    • 79956159637 scopus 로고    scopus 로고
    • Urine metabolomic analysis identifies potential biomarkers and pathogenic pathways in kidney cancer
    • Kim K, Taylor SL, Ganti S, Guo L, Osier MV, Weiss RH. 2011. Urine metabolomic analysis identifies potential biomarkers and pathogenic pathways in kidney cancer. OMICS 15: 293–303.
    • (2011) OMICS , vol.15 , pp. 293-303
    • Kim, K.1    Taylor, S.L.2    Ganti, S.3    Guo, L.4    Osier, M.V.5    Weiss, R.H.6
  • 63
    • 84878275118 scopus 로고    scopus 로고
    • Characterising and correcting batch variation in an automated direct infusion mass spectrometry (DIMS) metabolomics workflow
    • Kirwan J, Broadhurst D, Davidson R, Viant M. 2013. Characterising and correcting batch variation in an automated direct infusion mass spectrometry (DIMS) metabolomics workflow. Anal Bioanal Chem 405: 5147–5157.
    • (2013) Anal Bioanal Chem , vol.405 , pp. 5147-5157
    • Kirwan, J.1    Broadhurst, D.2    Davidson, R.3    Viant, M.4
  • 64
    • 84941263818 scopus 로고    scopus 로고
    • Direct infusion mass spectrometry metabolomics dataset: a benchmark for data processing and quality control
    • Kirwan JA, Weber RJ, Broadhurst DI, Viant MR. 2014. Direct infusion mass spectrometry metabolomics dataset: a benchmark for data processing and quality control. Scientific Data 1.
    • (2014) Scientific Data , pp. 1
    • Kirwan, J.A.1    Weber, R.J.2    Broadhurst, D.I.3    Viant, M.R.4
  • 65
    • 79955615223 scopus 로고    scopus 로고
    • Derivatization of carboxylic acids with 4-APEBA for detection by positive-ion LC-ESI–MS (/MS) applied for the analysis of prostanoids and NSAID in urine
    • Kretschmer A, Giera M, Wijtmans M, De Vries L, Lingeman H, Irth H, Niessen W. 2011. Derivatization of carboxylic acids with 4-APEBA for detection by positive-ion LC-ESI–MS (/MS) applied for the analysis of prostanoids and NSAID in urine. J Chromatogr B 879: 1393–1401.
    • (2011) J Chromatogr B , vol.879 , pp. 1393-1401
    • Kretschmer, A.1    Giera, M.2    Wijtmans, M.3    De Vries, L.4    Lingeman, H.5    Irth, H.6    Niessen, W.7
  • 66
    • 80155213897 scopus 로고    scopus 로고
    • Comprehensive profiling of free and conjugated estrogens by capillary electrophoresis–time of flight/mass spectrometry
    • Kuehnbaum NL, Britz-McKibbin P. 2011. Comprehensive profiling of free and conjugated estrogens by capillary electrophoresis–time of flight/mass spectrometry. Anal chem 83: 8063–8068.
    • (2011) Anal chem , vol.83 , pp. 8063-8068
    • Kuehnbaum, N.L.1    Britz-McKibbin, P.2
  • 67
    • 0036558175 scopus 로고    scopus 로고
    • Quantitative detection of trichloroacetic acid in human urine using isotope dilution high-performance liquid chromatography-electrospray ionization tandem mass spectrometry
    • Kuklenyik Z, Ashley DL, Calafat AM. 2002. Quantitative detection of trichloroacetic acid in human urine using isotope dilution high-performance liquid chromatography-electrospray ionization tandem mass spectrometry. Anal chem 74: 2058–2063.
    • (2002) Anal chem , vol.74 , pp. 2058-2063
    • Kuklenyik, Z.1    Ashley, D.L.2    Calafat, A.M.3
  • 68
    • 84860239052 scopus 로고    scopus 로고
    • Discovery of common urinary biomarkers for hepatotoxicity induced by carbon tetrachloride, acetaminophen and methotrexate by mass spectrometry-based metabolomics
    • Kumar BS, Chung BC, Kwon OS, Jung BH. 2012. Discovery of common urinary biomarkers for hepatotoxicity induced by carbon tetrachloride, acetaminophen and methotrexate by mass spectrometry-based metabolomics. J Appl Toxicol 32: 505–520.
    • (2012) J Appl Toxicol , vol.32 , pp. 505-520
    • Kumar, B.S.1    Chung, B.C.2    Kwon, O.S.3    Jung, B.H.4
  • 69
    • 78149414251 scopus 로고    scopus 로고
    • Gas chromatography–mass spectrometry-based simultaneous quantitative analytical method for urinary oxysterols and bile acids in rats
    • Kumar BS, Chung BC, Lee Y-J, Yi HJ, Lee B-H, Jung BH. 2011. Gas chromatography–mass spectrometry-based simultaneous quantitative analytical method for urinary oxysterols and bile acids in rats. Anal Biochem 408: 242–252.
    • (2011) Anal Biochem , vol.408 , pp. 242-252
    • Kumar, B.S.1    Chung, B.C.2    Lee, Y.-J.3    Yi, H.J.4    Lee, B.-H.5    Jung, B.H.6
  • 70
    • 74649087166 scopus 로고    scopus 로고
    • Discovery of safety biomarkers for atorvastatin in rat urine using mass spectrometry based metabolomics combined with global and targeted approach
    • Kumar BS, Lee Y-J, Yi HJ, Chung BC, Jung BH. 2010. Discovery of safety biomarkers for atorvastatin in rat urine using mass spectrometry based metabolomics combined with global and targeted approach. Anal Chim Acta 661: 47–59.
    • (2010) Anal Chim Acta , vol.661 , pp. 47-59
    • Kumar, B.S.1    Lee, Y.-J.2    Yi, H.J.3    Chung, B.C.4    Jung, B.H.5
  • 71
    • 3042855893 scopus 로고    scopus 로고
    • Profiling of sulfoconjugates in urine by using precursor ion and neutral loss scans in tandem mass spectrometry. Application to the investigation of heavy metal toxicity in rats
    • Lafaye A, Junot C, Gall RL, Fritsch P, Ezan E, Tabet JC. 2004. Profiling of sulfoconjugates in urine by using precursor ion and neutral loss scans in tandem mass spectrometry. Application to the investigation of heavy metal toxicity in rats. J Mass Spectrom 39: 655–664.
    • (2004) J Mass Spectrom , vol.39 , pp. 655-664
    • Lafaye, A.1    Junot, C.2    Gall, R.L.3    Fritsch, P.4    Ezan, E.5    Tabet, J.C.6
  • 72
    • 33846986484 scopus 로고    scopus 로고
    • Human urine as test material in 1H NMR-based metabonomics: recommendations for sample preparation and storage
    • Lauridsen M, Hansen SH, Jaroszewski JW, Cornett C. 2007. Human urine as test material in 1H NMR-based metabonomics: recommendations for sample preparation and storage. Anal chem 79: 1181–1186.
    • (2007) Anal chem , vol.79 , pp. 1181-1186
    • Lauridsen, M.1    Hansen, S.H.2    Jaroszewski, J.W.3    Cornett, C.4
  • 73
    • 79960384696 scopus 로고    scopus 로고
    • Mass spectrometry strategies in metabolomics
    • Lei Z, Huhman DV, Sumner LW. 2011. Mass spectrometry strategies in metabolomics. J Biol Chem 286: 25435–25442.
    • (2011) J Biol Chem , vol.286 , pp. 25435-25442
    • Lei, Z.1    Huhman, D.V.2    Sumner, L.W.3
  • 74
    • 0006377051 scopus 로고
    • Evaluation of urinary lead concentrations. I. The significance of the specific gravity
    • Levine L, Fahy JP. 1945. Evaluation of urinary lead concentrations. I. The significance of the specific gravity. J Ind Hyg Toxicol 27:217–223.
    • (1945) J Ind Hyg Toxicol , vol.27 , pp. 217-223
    • Levine, L.1    Fahy, J.P.2
  • 75
    • 48749132804 scopus 로고    scopus 로고
    • Analytical strategies for LC–MS-based targeted metabolomics
    • Lu W, Bennett BD, Rabinowitz JD. 2008. Analytical strategies for LC–MS-based targeted metabolomics. J Chromatogr B 871: 236–242.
    • (2008) J Chromatogr B , vol.871 , pp. 236-242
    • Lu, W.1    Bennett, B.D.2    Rabinowitz, J.D.3
  • 76
    • 77953959136 scopus 로고    scopus 로고
    • Separation of isomers l-alanine and sarcosine in urine by electrospray ionization and tandem differential mobility analysis-mass spectrometry
    • Martínez-Lozano P, Rus J. 2010. Separation of isomers l-alanine and sarcosine in urine by electrospray ionization and tandem differential mobility analysis-mass spectrometry. J Am Soc Mass Spectrom 21: 1129–1132.
    • (2010) J Am Soc Mass Spectrom , vol.21 , pp. 1129-1132
    • Martínez-Lozano, P.1    Rus, J.2
  • 77
    • 84861759321 scopus 로고    scopus 로고
    • The application of mass spectrometry to proteomics and metabolomics in biomarker discovery and drug development
    • Mikami T, Aoki M, Kimura T. 2012. The application of mass spectrometry to proteomics and metabolomics in biomarker discovery and drug development. Curr Mol Pharmacol 5: 301–316.
    • (2012) Curr Mol Pharmacol , vol.5 , pp. 301-316
    • Mikami, T.1    Aoki, M.2    Kimura, T.3
  • 78
    • 2142772559 scopus 로고    scopus 로고
    • Comparison of specific gravity and creatinine for normalizing urinary reproductive hormone concentrations
    • Miller RC, Brindle E, Holman DJ, Shofer J, Klein NA, Soules MR, O'Connor KA. 2004. Comparison of specific gravity and creatinine for normalizing urinary reproductive hormone concentrations. Clin chem 50: 924–932.
    • (2004) Clin chem , vol.50 , pp. 924-932
    • Miller, R.C.1    Brindle, E.2    Holman, D.J.3    Shofer, J.4    Klein, N.A.5    Soules, M.R.6    O'Connor, K.A.7
  • 79
    • 84877944128 scopus 로고    scopus 로고
    • Metabolomics analysis for biomarker discovery: advances and challenges
    • Monteiro M, Carvalho M, Bastos M, Guedes de Pinho P. 2013. Metabolomics analysis for biomarker discovery: advances and challenges. Curr Med Chem 20: 257–271.
    • (2013) Curr Med Chem , vol.20 , pp. 257-271
    • Monteiro, M.1    Carvalho, M.2    Bastos, M.3    Guedes, D.P.P.4
  • 80
    • 69549128022 scopus 로고    scopus 로고
    • Heat-map visualization of gas chromatography-mass spectrometry based quantitative signatures on steroid metabolism
    • Moon J-Y, Jung H-J, Moon MH, Chung BC, Choi MH. 2009. Heat-map visualization of gas chromatography-mass spectrometry based quantitative signatures on steroid metabolism. J Am Soc Mass Spectrom 20: 1626–1637.
    • (2009) J Am Soc Mass Spectrom , vol.20 , pp. 1626-1637
    • Moon, J.-Y.1    Jung, H.-J.2    Moon, M.H.3    Chung, B.C.4    Choi, M.H.5
  • 82
    • 75949130452 scopus 로고    scopus 로고
    • Combining tissue transcriptomics and urine metabolomics for breast cancer biomarker identification
    • Nam H, Chung BC, Kim Y, Lee K, Lee D. 2009. Combining tissue transcriptomics and urine metabolomics for breast cancer biomarker identification. Bioinformatics 25: 3151–3157.
    • (2009) Bioinformatics , vol.25 , pp. 3151-3157
    • Nam, H.1    Chung, B.C.2    Kim, Y.3    Lee, K.4    Lee, D.5
  • 84
    • 84858790233 scopus 로고    scopus 로고
    • Innovation: Metabolomics: the apogee of the omics trilogy
    • Patti GJ, Yanes O, Siuzdak G. 2012. Innovation: Metabolomics: the apogee of the omics trilogy. Nat Rev Mol Cell Biol 13: 263–269.
    • (2012) Nat Rev Mol Cell Biol , vol.13 , pp. 263-269
    • Patti, G.J.1    Yanes, O.2    Siuzdak, G.3
  • 85
    • 84887407071 scopus 로고    scopus 로고
    • Liquid–liquid extraction combined with differential isotope dimethylaminophenacyl labeling for improved metabolomic profiling of organic acids
    • Peng J, Li L. 2013. Liquid–liquid extraction combined with differential isotope dimethylaminophenacyl labeling for improved metabolomic profiling of organic acids. Anal Chim Acta 803:97–105.
    • (2013) Anal Chim Acta , vol.803 , pp. 97-105
    • Peng, J.1    Li, L.2
  • 86
    • 49549099267 scopus 로고    scopus 로고
    • Analysis of hydrophilic metabolites by high-performance liquid chromatography–mass spectrometry using a silica hydride-based stationary phase
    • Pesek JJ, Matyska MT, Fischer SM, Sana TR. 2008. Analysis of hydrophilic metabolites by high-performance liquid chromatography–mass spectrometry using a silica hydride-based stationary phase. J Chromatogr A 1204: 48–55.
    • (2008) J Chromatogr A , vol.1204 , pp. 48-55
    • Pesek, J.J.1    Matyska, M.T.2    Fischer, S.M.3    Sana, T.R.4
  • 87
    • 70149093062 scopus 로고    scopus 로고
    • Analysis of hydrophilic metabolites in physiological fluids by HPLC-MS using a silica hydride-based stationary phase
    • Pesek JJ, Matyska MT, Loo JA, Fischer SM, Sana TR. 2009. Analysis of hydrophilic metabolites in physiological fluids by HPLC-MS using a silica hydride-based stationary phase. J Sep Sci 32: 2200–2208.
    • (2009) J Sep Sci , vol.32 , pp. 2200-2208
    • Pesek, J.J.1    Matyska, M.T.2    Loo, J.A.3    Fischer, S.M.4    Sana, T.R.5
  • 88
    • 33645226493 scopus 로고    scopus 로고
    • Comparison between external and internal standard calibration in the validation of an analytical method for 1-hydroxypyrene in human urine by high-performance liquid chromatography/tandem mass spectrometry
    • Pigini D, Cialdella A, Faranda P, Tranfo G. 2006. Comparison between external and internal standard calibration in the validation of an analytical method for 1-hydroxypyrene in human urine by high-performance liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom 20: 1013–1018.
    • (2006) Rapid Commun Mass Spectrom , vol.20 , pp. 1013-1018
    • Pigini, D.1    Cialdella, A.2    Faranda, P.3    Tranfo, G.4
  • 90
    • 21144435518 scopus 로고    scopus 로고
    • A rapid screening approach to metabonomics using UPLC and oa-TOF mass spectrometry: application to age, gender and diurnal variation in normal/Zucker obese rats and black, white and nude mice
    • Plumb RS, Granger JH, Stumpf CL, Johnson KA, Smith BW, Gaulitz S, Wilson ID, Castro-Perez J. 2005. A rapid screening approach to metabonomics using UPLC and oa-TOF mass spectrometry: application to age, gender and diurnal variation in normal/Zucker obese rats and black, white and nude mice. Analyst 130: 844–849.
    • (2005) Analyst , vol.130 , pp. 844-849
    • Plumb, R.S.1    Granger, J.H.2    Stumpf, C.L.3    Johnson, K.A.4    Smith, B.W.5    Gaulitz, S.6    Wilson, I.D.7    Castro-Perez, J.8
  • 91
    • 0345095459 scopus 로고    scopus 로고
    • Use of liquid chromatography/time-of-flight mass spectrometry and multivariate statistical analysis shows promise for the detection of drug metabolites in biological fluids
    • Plumb RS, Stumpf CL, Granger JH, Castro-Perez J, Haselden JN, Dear GJ. 2003. Use of liquid chromatography/time-of-flight mass spectrometry and multivariate statistical analysis shows promise for the detection of drug metabolites in biological fluids. Rapid Commun Mass Spectrom 17: 2632–2638.
    • (2003) Rapid Commun Mass Spectrom , vol.17 , pp. 2632-2638
    • Plumb, R.S.1    Stumpf, C.L.2    Granger, J.H.3    Castro-Perez, J.4    Haselden, J.N.5    Dear, G.J.6
  • 93
    • 78650301750 scopus 로고    scopus 로고
    • CE-MS for metabolomics: Developments and applications in the period 2008–2010
    • Ramautar R, Mayboroda OA, Somsen GW, de Jong GJ. 2011. CE-MS for metabolomics: Developments and applications in the period 2008–2010. Electrophoresis 32: 52–65.
    • (2011) Electrophoresis , vol.32 , pp. 52-65
    • Ramautar, R.1    Mayboroda, O.A.2    Somsen, G.W.3    de Jong, G.J.4
  • 95
    • 84871941512 scopus 로고    scopus 로고
    • CE-MS for metabolomics: Developments and applications in the period 2010–2012
    • Ramautar R, Somsen GW, de Jong GJ. 2013. CE-MS for metabolomics: Developments and applications in the period 2010–2012. Electrophoresis 34: 86–98.
    • (2013) Electrophoresis , vol.34 , pp. 86-98
    • Ramautar, R.1    Somsen, G.W.2    de Jong, G.J.3
  • 96
    • 17844368603 scopus 로고    scopus 로고
    • Urinary markers of adrenarche: reference values in healthy subjects, aged 3–18 years
    • Remer T, Boye KR, Hartmann MF, Wudy SA. 2005. Urinary markers of adrenarche: reference values in healthy subjects, aged 3–18 years. J Clin Endocrinol Metab 90: 2015–2021.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 2015-2021
    • Remer, T.1    Boye, K.R.2    Hartmann, M.F.3    Wudy, S.A.4
  • 99
    • 84864555788 scopus 로고    scopus 로고
    • Exploring the human urine metabolomic potentialities by comprehensive two-dimensional gas chromatography coupled to time of flight mass spectrometry
    • Rocha SM, Caldeira M, Carrola J, Santos M, Cruz N, Duarte IF. 2012. Exploring the human urine metabolomic potentialities by comprehensive two-dimensional gas chromatography coupled to time of flight mass spectrometry. J Chromatogr A 1252:155–163.
    • (2012) J Chromatogr A , vol.1252 , pp. 155-163
    • Rocha, S.M.1    Caldeira, M.2    Carrola, J.3    Santos, M.4    Cruz, N.5    Duarte, I.F.6
  • 100
    • 78650907092 scopus 로고    scopus 로고
    • Applications of liquid chromatography coupled to mass spectrometry-based metabolomics in clinical chemistry and toxicology: A review
    • Roux A, Lison D, Junot C, Heilier J-F. 2011. Applications of liquid chromatography coupled to mass spectrometry-based metabolomics in clinical chemistry and toxicology: A review. Clin Biochem 44: 119–135.
    • (2011) Clin Biochem , vol.44 , pp. 119-135
    • Roux, A.1    Lison, D.2    Junot, C.3    Heilier, J.-F.4
  • 101
    • 78650175031 scopus 로고    scopus 로고
    • Recent and potential developments in the analysis of urine: a review
    • Ryan D, Robards K, Prenzler P, Kendall M. 2011. Recent and potential developments in the analysis of urine: a review. Anal Chim Acta 684: 17–29.
    • (2011) Anal Chim Acta , vol.684 , pp. 17-29
    • Ryan, D.1    Robards, K.2    Prenzler, P.3    Kendall, M.4
  • 102
    • 85008749196 scopus 로고    scopus 로고
    • Derivatization in liquid chromatography for mass spectrometric detection
    • Santa T. 2013. Derivatization in liquid chromatography for mass spectrometric detection. Drug Discoveries Ther 7:(1).
    • (2013) Drug Discoveries Ther , vol.7 , pp. 1
    • Santa, T.1
  • 106
    • 0032057381 scopus 로고    scopus 로고
    • Urinary nucleosides
    • Schram KH. 1998. Urinary nucleosides. Mass Spectrom Rev 17: 131–251.
    • (1998) Mass Spectrom Rev , vol.17 , pp. 131-251
    • Schram, K.H.1
  • 107
    • 34548771197 scopus 로고    scopus 로고
    • Simultaneous LC/MS/MS determination of thiols and disulfides in urine samples based on differential labeling with ferrocene-based maleimides
    • Seiwert B, Karst U. 2007. Simultaneous LC/MS/MS determination of thiols and disulfides in urine samples based on differential labeling with ferrocene-based maleimides. Anal chem 79: 7131–7138.
    • (2007) Anal chem , vol.79 , pp. 7131-7138
    • Seiwert, B.1    Karst, U.2
  • 108
    • 40949115391 scopus 로고    scopus 로고
    • Quantitative analysis of 17 amino acids in the connective tissue of patients with pelvic organ prolapse using capillary electrophoresis–tandem mass spectrometry
    • Shama N, Bai SW, Chung BC, Jung BH. 2008. Quantitative analysis of 17 amino acids in the connective tissue of patients with pelvic organ prolapse using capillary electrophoresis–tandem mass spectrometry. J Chromatogr B 865: 18–24.
    • (2008) J Chromatogr B , vol.865 , pp. 18-24
    • Shama, N.1    Bai, S.W.2    Chung, B.C.3    Jung, B.H.4
  • 110
    • 0242569355 scopus 로고    scopus 로고
    • Quantitative metabolome analysis using capillary electrophoresis mass spectrometry
    • Soga T, Ohashi Y, Ueno Y, Naraoka H, Tomita M, Nishioka T. 2003. Quantitative metabolome analysis using capillary electrophoresis mass spectrometry. J Proteome Res 2: 488–494.
    • (2003) J Proteome Res , vol.2 , pp. 488-494
    • Soga, T.1    Ohashi, Y.2    Ueno, Y.3    Naraoka, H.4    Tomita, M.5    Nishioka, T.6
  • 112
    • 4344663297 scopus 로고    scopus 로고
    • Switching from an analogous to a stable isotopically labeled internal standard for the LC-MS/MS quantitation of the novel anticancer drug Kahalalide F significantly improves assay performance
    • Stokvis E, Rosing H, López-Lázaro L, Schellens J, Beijnen J. 2004. Switching from an analogous to a stable isotopically labeled internal standard for the LC-MS/MS quantitation of the novel anticancer drug Kahalalide F significantly improves assay performance. Biomed Chromatogr 18: 400–402.
    • (2004) Biomed Chromatogr , vol.18 , pp. 400-402
    • Stokvis, E.1    Rosing, H.2    López-Lázaro, L.3    Schellens, J.4    Beijnen, J.5
  • 115
    • 31644441750 scopus 로고    scopus 로고
    • Determination of the GABA analogue succinic semialdehyde in urine and cerebrospinal fluid by dinitrophenylhydrazine derivatization and liquid chromatography–tandem mass spectrometry: application to SSADH deficiency
    • Struys E, Jansen E, Gibson K, Jakobs C. 2005. Determination of the GABA analogue succinic semialdehyde in urine and cerebrospinal fluid by dinitrophenylhydrazine derivatization and liquid chromatography–tandem mass spectrometry: application to SSADH deficiency. J Inherited Metab Dis 28: 913–920.
    • (2005) J Inherited Metab Dis , vol.28 , pp. 913-920
    • Struys, E.1    Jansen, E.2    Gibson, K.3    Jakobs, C.4
  • 116
    • 33947392610 scopus 로고    scopus 로고
    • Urine stability for metabolomic studies: effects of preparation and storage
    • Sykes BD. 2007. Urine stability for metabolomic studies: effects of preparation and storage. Metabolomics 3: 19–27.
    • (2007) Metabolomics , vol.3 , pp. 19-27
    • Sykes, B.D.1
  • 117
    • 79960495785 scopus 로고    scopus 로고
    • Mass spectrometry-based holistic analytical approaches for metabolite profiling in systems biology studies
    • Theodoridis G, Gika HG, Wilson ID. 2011. Mass spectrometry-based holistic analytical approaches for metabolite profiling in systems biology studies. Mass Spectrom Rev 30: 884–906.
    • (2011) Mass Spectrom Rev , vol.30 , pp. 884-906
    • Theodoridis, G.1    Gika, H.G.2    Wilson, I.D.3
  • 118
    • 83055186403 scopus 로고    scopus 로고
    • Liquid chromatography–mass spectrometry based global metabolite profiling: a review
    • Theodoridis GA, Gika HG, Want EJ, Wilson ID. 2012. Liquid chromatography–mass spectrometry based global metabolite profiling: a review. Anal Chim Acta 711:7–16.
    • (2012) Anal Chim Acta , vol.711 , pp. 7-16
    • Theodoridis, G.A.1    Gika, H.G.2    Want, E.J.3    Wilson, I.D.4
  • 119
    • 84865075561 scopus 로고    scopus 로고
    • LC–MS determination of bioactive molecules based upon stable isotope-coded derivatization method
    • Toyo'oka T. 2012. LC–MS determination of bioactive molecules based upon stable isotope-coded derivatization method. J Pharm Biomed Anal 69:174–184.
    • (2012) J Pharm Biomed Anal , vol.69 , pp. 174-184
    • Toyo'oka, T.1
  • 120
    • 84907383814 scopus 로고    scopus 로고
    • Do not just do it, do it right: urinary metabolomics–establishing clinically relevant baselines
    • Trivedi DK, Iles RK. 2014a. Do not just do it, do it right: urinary metabolomics–establishing clinically relevant baselines. Biomed Chromatogr DOI: 10.1002/bmc.3219
    • (2014) Biomed Chromatogr
    • Trivedi, D.K.1    Iles, R.K.2
  • 121
    • 84921593740 scopus 로고    scopus 로고
    • HILIC-MS-based shotgun metabolomic profiling of maternal urine at 9–23 weeks of gestation–establishing the baseline changes in the maternal metabolome
    • Trivedi DK, Iles RK. 2014b. HILIC-MS-based shotgun metabolomic profiling of maternal urine at 9–23 weeks of gestation–establishing the baseline changes in the maternal metabolome. Biomed Chromatogr DOI: 10.1002/bmc.3266
    • (2014) Biomed Chromatogr
    • Trivedi, D.K.1    Iles, R.K.2
  • 122
    • 84911481439 scopus 로고    scopus 로고
    • Development of Zwitterionic Hydrophilic Liquid Chromatography (ZIC®HILIC-MS) Metabolomics Method for Shotgun Analysis of Human Urine
    • Trivedi DK, Jones H, Shah A, Iles RK. 2012. Development of Zwitterionic Hydrophilic Liquid Chromatography (ZIC®HILIC-MS) Metabolomics Method for Shotgun Analysis of Human Urine. J Chromatogr Sep Tech 3: 144.
    • (2012) J Chromatogr Sep Tech , vol.3 , pp. 144
    • Trivedi, D.K.1    Jones, H.2    Shah, A.3    Iles, R.K.4
  • 123
    • 0242407229 scopus 로고    scopus 로고
    • Deuterium isotope effects on hydrophobic interactions: the importance of dispersion interactions in the hydrophobic phase
    • Turowski M, Yamakawa N, Meller J, Kimata K, Ikegami T, Hosoya K, Tanaka N, Thornton ER. 2003. Deuterium isotope effects on hydrophobic interactions: the importance of dispersion interactions in the hydrophobic phase. J Am Chem Soc 125: 13836–13849.
    • (2003) J Am Chem Soc , vol.125 , pp. 13836-13849
    • Turowski, M.1    Yamakawa, N.2    Meller, J.3    Kimata, K.4    Ikegami, T.5    Hosoya, K.6    Tanaka, N.7    Thornton, E.R.8
  • 124
    • 67949095917 scopus 로고    scopus 로고
    • Radiation metabolomics. 2. Dose-and time-dependent urinary excretion of deaminated purines and pyrimidines after sublethal gamma-radiation exposure in mice
    • Tyburski JB, Patterson AD, Krausz KW, Slavík J, Fornace AJ, Jr, Gonzalez FJ, Idle JR. 2009. Radiation metabolomics. 2. Dose-and time-dependent urinary excretion of deaminated purines and pyrimidines after sublethal gamma-radiation exposure in mice. Radiation research 172: 42–57.
    • (2009) Radiation research , vol.172 , pp. 42-57
    • Tyburski, J.B.1    Patterson, A.D.2    Krausz, K.W.3    Slavík, J.4    Fornace, A.J.5    Gonzalez, F.J.6    Idle, J.R.7
  • 125
    • 0037992700 scopus 로고    scopus 로고
    • Urea hydrolysis and precipitation dynamics in a urine-collecting system
    • Udert KM, Larsen TA, Biebow M, Gujer W. 2003. Urea hydrolysis and precipitation dynamics in a urine-collecting system. Water Research 37: 2571–2582.
    • (2003) Water Research , vol.37 , pp. 2571-2582
    • Udert, K.M.1    Larsen, T.A.2    Biebow, M.3    Gujer, W.4
  • 127
    • 55549143295 scopus 로고    scopus 로고
    • Quantitative determination of endogenous compounds in biological samples using chromatographic techniques. TrAC
    • van de Merbel NC. 2008. Quantitative determination of endogenous compounds in biological samples using chromatographic techniques. TrAC. Trends Anal Chem 27: 924–933.
    • (2008) Trends Anal Chem , vol.27 , pp. 924-933
    • van de Merbel, N.C.1
  • 128
    • 34247397544 scopus 로고    scopus 로고
    • Evaluation of metabolite profiles as biomarkers for the pharmacological effects of thiazolidinediones in Type 2 diabetes mellitus patients and healthy volunteers
    • Van Doorn M, Vogels J, Tas A, Van Hoogdalem EJ, Burggraaf J, Cohen A, Van Der Greef J. 2007. Evaluation of metabolite profiles as biomarkers for the pharmacological effects of thiazolidinediones in Type 2 diabetes mellitus patients and healthy volunteers. Br J Clin Pharmacol 63: 562–574.
    • (2007) Br J Clin Pharmacol , vol.63 , pp. 562-574
    • Van Doorn, M.1    Vogels, J.2    Tas, A.3    Van Hoogdalem, E.J.4    Burggraaf, J.5    Cohen, A.6    Van Der Greef, J.7
  • 129
    • 79551574144 scopus 로고    scopus 로고
    • Metabolic profiling for the detection of bladder cancer
    • Van QN, Veenstra TD, Issaq HJ. 2011. Metabolic profiling for the detection of bladder cancer. Curr Urol Rep 12: 34–40.
    • (2011) Curr Urol Rep , vol.12 , pp. 34-40
    • Van, Q.N.1    Veenstra, T.D.2    Issaq, H.J.3
  • 130
    • 2542450032 scopus 로고    scopus 로고
    • Creatinine normalization in biological monitoring revisited: the case of 1-hydroxypyrene
    • Viau C, Lafontaine M, Payan J. 2004. Creatinine normalization in biological monitoring revisited: the case of 1-hydroxypyrene. Int Arch Occup Environ Health 77: 177–185.
    • (2004) Int Arch Occup Environ Health , vol.77 , pp. 177-185
    • Viau, C.1    Lafontaine, M.2    Payan, J.3
  • 131
    • 79953292657 scopus 로고    scopus 로고
    • Alkylation or silylation for analysis of amino and non-amino organic acids by GC-MS?
    • Villas-Bôas SG, Smart KF, Sivakumaran S, Lane GA. 2011. Alkylation or silylation for analysis of amino and non-amino organic acids by GC-MS?. Metabolites 1: 3–20.
    • (2011) Metabolites , vol.1 , pp. 3-20
    • Villas-Bôas, S.G.1    Smart, K.F.2    Sivakumaran, S.3    Lane, G.A.4
  • 132
    • 84861230997 scopus 로고    scopus 로고
    • Current trends and challenges in sample preparation for global metabolomics using liquid chromatography–mass spectrometry
    • Vuckovic D. 2012. Current trends and challenges in sample preparation for global metabolomics using liquid chromatography–mass spectrometry. Anal Bioanal Chem 403: 1523–1548.
    • (2012) Anal Bioanal Chem , vol.403 , pp. 1523-1548
    • Vuckovic, D.1
  • 133
    • 0033034701 scopus 로고    scopus 로고
    • Deuterium isotope effects on noncovalent interactions between molecules
    • Wade D. 1999. Deuterium isotope effects on noncovalent interactions between molecules. Chem-Biol Interact 117: 191–217.
    • (1999) Chem-Biol Interact , vol.117 , pp. 191-217
    • Wade, D.1
  • 134
    • 33144456906 scopus 로고    scopus 로고
    • Metabonomics and biomarker discovery: LC-MS metabolic profiling and constant neutral loss scanning combined with multivariate data analysis for mercapturic acid analysis
    • Wagner S, Scholz K, Donegan M, Burton L, Wingate J, Völkel W. 2006. Metabonomics and biomarker discovery: LC-MS metabolic profiling and constant neutral loss scanning combined with multivariate data analysis for mercapturic acid analysis. Anal chem 78: 1296–1305.
    • (2006) Anal chem , vol.78 , pp. 1296-1305
    • Wagner, S.1    Scholz, K.2    Donegan, M.3    Burton, L.4    Wingate, J.5    Völkel, W.6
  • 135
    • 83455208035 scopus 로고    scopus 로고
    • Ultra-performance liquid chromatography coupled to mass spectrometry as a sensitive and powerful technology for metabolomic studies
    • Wang X, Sun H, Zhang A, Wang P, Han Y. 2011. Ultra-performance liquid chromatography coupled to mass spectrometry as a sensitive and powerful technology for metabolomic studies. J Sep Sci 34: 3451–3459.
    • (2011) J Sep Sci , vol.34 , pp. 3451-3459
    • Wang, X.1    Sun, H.2    Zhang, A.3    Wang, P.4    Han, Y.5
  • 136
    • 84864828304 scopus 로고    scopus 로고
    • Urine metabolomics analysis for biomarker discovery and detection of jaundice syndrome in patients with liver disease
    • Wang X, Zhang A, Han Y, Wang P, Sun H, Song G, Dong T, Yuan Y, Yuan X, Zhang M. 2012. Urine metabolomics analysis for biomarker discovery and detection of jaundice syndrome in patients with liver disease. Mol Cell Proteomics 11: 370–380.
    • (2012) Mol Cell Proteomics , vol.11 , pp. 370-380
    • Wang, X.1    Zhang, A.2    Han, Y.3    Wang, P.4    Sun, H.5    Song, G.6    Dong, T.7    Yuan, Y.8    Yuan, X.9    Zhang, M.10
  • 139
    • 0037082154 scopus 로고    scopus 로고
    • Quantification of 8-oxo-guanine and guanine as the nucleobase, nucleoside and deoxynucleoside forms in human urine by high-performance liquid chromatography–electrospray tandem mass spectrometry
    • Weimann A, Belling D, Poulsen HE. 2002. Quantification of 8-oxo-guanine and guanine as the nucleobase, nucleoside and deoxynucleoside forms in human urine by high-performance liquid chromatography–electrospray tandem mass spectrometry. Nucleic Acids Res 30: e7–e7.
    • (2002) Nucleic Acids Res , vol.30 , pp. e7
    • Weimann, A.1    Belling, D.2    Poulsen, H.E.3
  • 141
    • 17444404226 scopus 로고    scopus 로고
    • High resolution “ultra performance” liquid chromatography coupled to oa-TOF mass spectrometry as a tool for differential metabolic pathway profiling in functional genomic studies
    • Wilson ID, Nicholson JK, Castro-Perez J, Granger JH, Johnson KA, Smith BW, Plumb RS. 2005. High resolution “ultra performance” liquid chromatography coupled to oa-TOF mass spectrometry as a tool for differential metabolic pathway profiling in functional genomic studies. J Proteome Res 4: 591–598.
    • (2005) J Proteome Res , vol.4 , pp. 591-598
    • Wilson, I.D.1    Nicholson, J.K.2    Castro-Perez, J.3    Granger, J.H.4    Johnson, K.A.5    Smith, B.W.6    Plumb, R.S.7
  • 143
    • 10744228656 scopus 로고    scopus 로고
    • Determination of peptides and proteins in human urine with capillary electrophoresis–mass spectrometry, a suitable tool for the establishment of new diagnostic markers
    • Wittke S, Fliser D, Haubitz M, Bartel S, Krebs R, Hausadel F, Hillmann M, Golovko I, Koester P, Haller H. 2003. Determination of peptides and proteins in human urine with capillary electrophoresis–mass spectrometry, a suitable tool for the establishment of new diagnostic markers. J Chromatogr A 1013: 173–181.
    • (2003) J Chromatogr A , vol.1013 , pp. 173-181
    • Wittke, S.1    Fliser, D.2    Haubitz, M.3    Bartel, S.4    Krebs, R.5    Hausadel, F.6    Hillmann, M.7    Golovko, I.8    Koester, P.9    Haller, H.10
  • 144
    • 78649474974 scopus 로고    scopus 로고
    • Evaluation of comprehensive two-dimensional gas chromatography coupled to time-of-flight mass spectrometry for the diagnosis of inherited metabolic disorders using an automated data processing strategy
    • Wojtowicz P, Zrostlíková J, Kovalczuk T, Schůrek J, Adam T. 2010. Evaluation of comprehensive two-dimensional gas chromatography coupled to time-of-flight mass spectrometry for the diagnosis of inherited metabolic disorders using an automated data processing strategy. J Chromatogr A 1217: 8054–8061.
    • (2010) J Chromatogr A , vol.1217 , pp. 8054-8061
    • Wojtowicz, P.1    Zrostlíková, J.2    Kovalczuk, T.3    Schůrek, J.4    Adam, T.5
  • 146
    • 67650388695 scopus 로고    scopus 로고
    • Metabolomic profiling of human urine in hepatocellular carcinoma patients using gas chromatography/mass spectrometry
    • Wu H, Xue R, Dong L, Liu T, Deng C, Zeng H, Shen X. 2009. Metabolomic profiling of human urine in hepatocellular carcinoma patients using gas chromatography/mass spectrometry. Anal Chim Acta 648: 98–104.
    • (2009) Anal Chim Acta , vol.648 , pp. 98-104
    • Wu, H.1    Xue, R.2    Dong, L.3    Liu, T.4    Deng, C.5    Zeng, H.6    Shen, X.7
  • 147
    • 84871258276 scopus 로고    scopus 로고
    • Determination of Total Concentration of Chemically Labeled Metabolites as a Means of Metabolome Sample Normalization and Sample Loading Optimization in Mass Spectrometry-Based Metabolomics
    • Wu Y, Li L. 2012. Determination of Total Concentration of Chemically Labeled Metabolites as a Means of Metabolome Sample Normalization and Sample Loading Optimization in Mass Spectrometry-Based Metabolomics. Anal chem 84: 10723–10731.
    • (2012) Anal chem , vol.84 , pp. 10723-10731
    • Wu, Y.1    Li, L.2
  • 148
    • 27144527808 scopus 로고    scopus 로고
    • Measuring fifteen endogenous estrogens simultaneously in human urine by high-performance liquid chromatography-mass spectrometry
    • Xu X, Veenstra TD, Fox SD, Roman JM, Issaq HJ, Falk R, Saavedra JE, Keefer LK, Ziegler RG. 2005. Measuring fifteen endogenous estrogens simultaneously in human urine by high-performance liquid chromatography-mass spectrometry. Anal chem 77: 6646–6654.
    • (2005) Anal chem , vol.77 , pp. 6646-6654
    • Xu, X.1    Veenstra, T.D.2    Fox, S.D.3    Roman, J.M.4    Issaq, H.J.5    Falk, R.6    Saavedra, J.E.7    Keefer, L.K.8    Ziegler, R.G.9
  • 149
    • 0037175439 scopus 로고    scopus 로고
    • Stable isotope dilution high-performance liquid chromatography–electrospray ionization mass spectrometry method for endogenous 2-and 4-hydroxyestrones in human urine
    • Xu X, Ziegler RG, Waterhouse DJ, Saavedra JE, Keefer LK. 2002. Stable isotope dilution high-performance liquid chromatography–electrospray ionization mass spectrometry method for endogenous 2-and 4-hydroxyestrones in human urine. J Chromatogr B 780: 315–330.
    • (2002) J Chromatogr B , vol.780 , pp. 315-330
    • Xu, X.1    Ziegler, R.G.2    Waterhouse, D.J.3    Saavedra, J.E.4    Keefer, L.K.5
  • 150
    • 43649108595 scopus 로고    scopus 로고
    • Simultaneous determination of tetrahydrocortisol, allotetrahydrocortisol and tetrahydrocortisone in human urine by liquid chromatography-electrospray ionization tandem mass spectrometry
    • Yamashita K, Nakagawa R, Okuyama M, Honma S, Takahashi M, Numazawa M. 2008. Simultaneous determination of tetrahydrocortisol, allotetrahydrocortisol and tetrahydrocortisone in human urine by liquid chromatography-electrospray ionization tandem mass spectrometry. Steroids 73: 727–737.
    • (2008) Steroids , vol.73 , pp. 727-737
    • Yamashita, K.1    Nakagawa, R.2    Okuyama, M.3    Honma, S.4    Takahashi, M.5    Numazawa, M.6
  • 151
    • 59249101572 scopus 로고    scopus 로고
    • Comparative metabolite profiling of carboxylic acids in rat urine by CE-ESI MS/MS through positively pre-charged and 2H-coded derivatization
    • Yang WC, Regnier FE, Adamec J. 2008. Comparative metabolite profiling of carboxylic acids in rat urine by CE-ESI MS/MS through positively pre-charged and 2H-coded derivatization. Electrophoresis 29: 4549–4560.
    • (2008) Electrophoresis , vol.29 , pp. 4549-4560
    • Yang, W.C.1    Regnier, F.E.2    Adamec, J.3
  • 152
    • 0022347180 scopus 로고
    • Endogenous formation of dimethylamine
    • Zeisel SH, DaCosta KA, Fox JG. 1985. Endogenous formation of dimethylamine. Biochem J 232:403–408.
    • (1985) Biochem J , vol.232 , pp. 403-408
    • Zeisel, S.H.1    DaCosta, K.A.2    Fox, J.G.3
  • 153
    • 83455203337 scopus 로고    scopus 로고
    • Modern analytical techniques in metabolomics analysis
    • Zhang A, Sun H, Wang P, Han Y, Wang X. 2012a. Modern analytical techniques in metabolomics analysis. Analyst 137: 293–300.
    • (2012) Analyst , vol.137 , pp. 293-300
    • Zhang, A.1    Sun, H.2    Wang, P.3    Han, Y.4    Wang, X.5
  • 155
    • 84863422028 scopus 로고    scopus 로고
    • Evaluation of coupling reversed phase, aqueous normal phase, and hydrophilic interaction liquid chromatography with Orbitrap mass spectrometry for metabolomic studies of human urine
    • Zhang T, Creek DJ, Barrett MP, Blackburn G, Watson DG. 2012c. Evaluation of coupling reversed phase, aqueous normal phase, and hydrophilic interaction liquid chromatography with Orbitrap mass spectrometry for metabolomic studies of human urine. Anal chem 84: 1994–2001.
    • (2012) Anal chem , vol.84 , pp. 1994-2001
    • Zhang, T.1    Creek, D.J.2    Barrett, M.P.3    Blackburn, G.4    Watson, D.G.5
  • 157
    • 84862780180 scopus 로고    scopus 로고
    • Fragmentation of protonated dansyl-labeled amines for structural analysis of amine-containing metabolites
    • Zheng J, Li L. 2012. Fragmentation of protonated dansyl-labeled amines for structural analysis of amine-containing metabolites. International J Mass Spectrom 316:292–299.
    • (2012) International J Mass Spectrom , vol.316 , pp. 292-299
    • Zheng, J.1    Li, L.2
  • 158
    • 72449182598 scopus 로고    scopus 로고
    • Urinary metabonomic study on biochemical changes in chronic unpredictable mild stress model of depression
    • Zheng S, Yu M, Lu X, Huo T, Ge L, Yang J, Wu C, Li F. 2010. Urinary metabonomic study on biochemical changes in chronic unpredictable mild stress model of depression. Clin Chim Acta 411: 204–209.
    • (2010) Clin Chim Acta , vol.411 , pp. 204-209
    • Zheng, S.1    Yu, M.2    Lu, X.3    Huo, T.4    Ge, L.5    Yang, J.6    Wu, C.7    Li, F.8
  • 159
    • 84889040799 scopus 로고    scopus 로고
    • 5-Diethylamino-naphthalene-1-sulfonyl Chloride (DensCl): A novel triplex isotope labeling reagent for quantitative metabolome analysis by liquid chromatography mass spectrometry
    • Zhou R, Guo K, Li L. 2013. 5-Diethylamino-naphthalene-1-sulfonyl Chloride (DensCl): A novel triplex isotope labeling reagent for quantitative metabolome analysis by liquid chromatography mass spectrometry. Anal chem 85: 11532–11539.
    • (2013) Anal chem , vol.85 , pp. 11532-11539
    • Zhou, R.1    Guo, K.2    Li, L.3
  • 160
    • 84901269837 scopus 로고    scopus 로고
    • IsoMS: Automated Processing of LC-MS Data Generated by a Chemical Isotope Labeling Metabolomics Platform
    • Zhou R, Tseng C-L, Huan T, Li L. 2014. IsoMS: Automated Processing of LC-MS Data Generated by a Chemical Isotope Labeling Metabolomics Platform. Anal chem 86: 4675–4679.
    • (2014) Anal chem , vol.86 , pp. 4675-4679
    • Zhou, R.1    Tseng, C.-L.2    Huan, T.3    Li, L.4


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