Development and performance of a gas chromatography-time-of-flight mass spectrometry analysis for large-scale nontargeted metabolomic studies of human serum

Analytical Chemistry

Volumn 81, Issue 16, 2009, Pages 7038-7046

  Begley, Paul ^a   Francis McIntyre, Sue ^a   Dunn, Warwick B ^a   Broadhurst, David I ^a   Halsall, Antony ^a   Tseng, Andy ^a   Knowles, Joshua ^a   Goodacre, Royston ^a   Kell, Douglas B ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANALYSIS TIME; CHEMICAL DERIVATIZATION; DERIVATIZATIONS; EXCELLENT PERFORMANCE; GC-TOF-MS; HUMAN SERUM; METABOLOMIC STUDY; NON-TARGETED; PROCESS VARIABILITY; REPRODUCIBILITIES; SERUM SAMPLES; TIME OF FLIGHT MASS SPECTROMETRY; TWO-STAGE PROCESS;

ABILITY TESTING; BODY FLUIDS; CHROMATOGRAPHIC ANALYSIS; CONCENTRATION (PROCESS); GAS CHROMATOGRAPHY; INDUCTIVELY COUPLED PLASMA; MASS SPECTROMETERS; MASS SPECTROMETRY; METABOLISM; METABOLITES; QUALITY ASSURANCE; QUALITY FUNCTION DEPLOYMENT; STANDARDS; TOTAL QUALITY MANAGEMENT;

QUALITY CONTROL;

METHANOL;

ARTICLE; CONTROLLED STUDY; DERIVATIZATION; GAS CHROMATOGRAPHY; HUMAN; METABOLITE; METABOLOMICS; NORMAL HUMAN; QUALITY CONTROL; REPRODUCIBILITY; SERUM; TIME OF FLIGHT MASS SPECTROMETRY;

BLOOD PROTEINS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; METABOLOMICS; QUALITY CONTROL; REPRODUCIBILITY OF RESULTS;

EID: 68849116797     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac9011599     Document Type: Article

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