Urinary metabolic fingerprinting for amiodarone-induced phospholipidosis in rats using FT-ICR MS

Experimental and Toxicologic Pathology

Volumn 59, Issue 2, 2007, Pages 115-120

  Hasegawa, Mina ^a   Takenaka, Shigeo ^a   Kuwamura, Mitsuru ^a   Yamate, Jyoji ^a   Tsuyama, Shingo ^a  

^a Osaka Prefecture University   (Japan)

Author keywords

Amiodarone; FT ICR MS; Metabolic fingerprinting; Phospholipidosis; Rat; Urine

Indexed keywords

AMIODARONE; BIOLOGICAL MARKER; GLYCINE DERIVATIVE; HIPPURIC ACID; INDICAN; ION;

ANALYTIC METHOD; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE MODEL; HISTOPATHOLOGY; ION CYCLOTRON RESONANCE MASS SPECTROMETRY; LIPIDOSIS; NONHUMAN; PRINCIPAL COMPONENT ANALYSIS; RAT; TIME; URINARY METABOLIC FINGERPRINTING;

RATTUS;

EID: 34548618455     PISSN: 09402993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.etp.2007.04.001     Document Type: Article

References (36)

1. Aharoni A., Ric de Vos C.H., Verhoeven H.A., Maliepaard C.A., Kruppa G., Bino R., et al. Nontargeted metabolome analysis by use of Fourier Transform Ion Cyclotron Mass Spectrometry. OMICS 6 (2002) 217-234
2. Armstrong M.D., and Robinson K.S. On the excretion of indole derivatives in phenylketonuria. Arch Biochem 52 (1954) 287-288
3. Bessman S.P., and Tada K. Indicanuria in phenylketonuria. Metabolism 9 (1960) 377-385
4. Bollard M.E., Keun H.C., Beckonert O., Ebbels T.M., Antti H., Nicholls A.W., et al. Comparative metabonomics of differential hydrazine toxicity in the rat and mouse. Toxicol Appl Pharmacol 204 (2005) 135-151
5. Brown S.C., Kruppa G., and Dasseux J.L. Metabolomics applications of FT-ICR mass spectrometry. Mass Spectrom Rev 24 (2005) 223-231
6. Connor S.C., Wu W., Sweatman B.C., Manini J., Haselden J.N., Crowther D.J., et al. Effects of feeding and body weight loss on the 1H-NMR-based urine metabolic profiles of male Wistar Han rats: implications for biomarker discovery. Biomarkers 9 (2004) 156-179
7. Delaney J., Neville W.A., Swain A., Miles A., Leonard M.S., and Waterfield C.J. Phenylacetylglycine, a putative biomarker of phospholipidosis: its origins and relevance to phospholipid accumulation using amiodarone treated rats as a model. Biomarkers 9 (2004) 271-290
8. Dieterle F., Ross A., Schlotterbeck G., and Senn H. Metabolite projection analysis for fast identification of metabolites in metabonomics. Application in an amiodarone study. Anal Chem 78 (2006) 3551-3561
9. Erlandsen H., and Stevens R.C. The structural basis of phenylketonuria. Mol Genet Metab 68 (1999) 103-125
10. Espina J.R., Shockcor J.P., Herron W.J., Car B.D., Conte N.R., Ciaccio P.J., et al. Detection of in vivo biomarkers of phospholipidosis using NMR-based metabonomic approaches. Magn Reson Chem 39 (2001) 559-565
11. Fiehn O. Metabolomics - the link between genotypes and phenotypes. Plant Mol Biol 48 (2002) 155-171
12. Gavaghan C.L., Holmes E., Lenz E., Wilson I.D., and Nicholson J.K. An NMR-based metabonomic approach to investigate the biochemical consequences of genetic strain differences: application to the C57BL10J and Alpk: ApfCD mouse. FEBS Lett 484 (2000) 169-174
13. Gonzalez-Rothi R.J., Zander D.S., and Ros P.R. Fluoxetine hydrochloride (Prozac)-induced pulmonary disease. Chest 107 (1995) 1763-1765
14. Halket J.M., Przyborowska A., Stein S.E., Mallard W.G., Down S., and Chalmers R.A. Deconvolution gas chromatography/mass spectrometry of urinary organic acids - potential for pattern recognition and automated identification of metabolic disorders. Rapid Commun Mass Spectrom 13 (1999) 279-284
15. Halliwell W.H. Cationic amphiphilic drug-induced phospholipidosis. Toxicol Pathol 25 (1997) 53-60
16. Holmes E., Foxall P.J., Spraul M., Farrant R.D., Nicholson J.K., and Lindon J.C. 750 MHz 1H NMR spectroscopy characterisation of the complex metabolic pattern of urine from patients with inborn errors of metabolism: 2-hydroxyglutaric aciduria and maple syrup urine disease. J Pharm Biomed Anal 15 (1997) 1647-1659
17. Holmes E., Nicholls A.W., Lindon J.C., Connor S.C., Connelly J.C., Haselden J.N., et al. Chemometric models for toxicity classification based on NMR spectra of biofluids. Chem Res Toxicol 13 (2000) 471-478
18. Idborg-Bjorkman H., Edlund P.O., Kvalheim O.M., Schuppe-Koistinen I., and Jacobsson S.P. Screening of biomarkers in rat urine using LC/electrospray ionization-MS and two-way data analysis. Anal Chem 75 (2003) 4784-4792
19. James M.O., Smith R.L., Williams R.T., and Reidenberg M. The conjugation of phenylacetic acid in man, sub-human primates and some non-primate species. Proc R Soc London B Biol Sci 182 (1972) 25-35
20. Lullmann H., Lullmann-Rauch R., and Wassermann O. Lipidosis induced by amphiphilic cationic drugs. Biochem Pharmacol 27 (1978) 1103-1108
21. Marshall A.G., Hendrickson C.L., and Jackson G.S. Fourier transform ion cyclotron resonance mass spectrometry: a primer. Mass Spectrom Rev 17 (1998) 1-35
22. Martin W.J.2n., and Standing J.E. Amiodarone pulmonary toxicity: biochemical evidence for a cellular phospholipidosis in the bronchoalveolar lavage of human subjects. J Pharmacol Exp Ther 244 (1988) 774-779
23. Michals K., and Matalon R. Phenylalanine metabolites, attention span and hyperactivity. Am J Clin Nutr 42 (1985) 361-365
24. Nicholls A.W., Nicholson J.K., Haselden J.N., and Waterfield C.J. A metabonomic approach to the investigation of drug-induced phospholipidosis: an NMR spectroscopy and pattern recognition study. Biomarkers 5 (2000) 410-423
25. Nicholls A.W., Mortishire-Smith R.J., and Nicholson J.K. NMR spectroscopic-based metabonomic studies of urinary metabolite variation in acclimatizing germ-free rats. Chem Res Toxicol 16 (2003) 1395-1404
26. Nicholson J.K., Lindon J.C., and Holmes E. 'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. Xenobiotica 29 (1999) 1181-1189
27. Pham-Tuan H., Kaskavelis L., Daykin C.A., and Janssen H.G. Method development in high-performance liquid chromatography for high-throughput profiling and metabonomic studies of biofluid samples. J Chromatogr B Anal Technol Biomed Life Sci 789 (2003) 283-301
28. Plumb R.S., Stumpf C.L., Gorenstein M.V., Castro-Perez J.M., Dear G.J., Anthony M., et al. Metabonomics: the use of electrospray mass spectrometry coupled to reversed-phase liquid chromatography shows potential for the screening of rat urine in drug development. Rapid Commun Mass Spectrom 16 (2002) 1991-1996
29. Pessayre D., Bichara M., Degott C., Potet F., Benhamou J.P., and Feldmann G. Perhexiline maleate-induced cirrhosis. Gastroenterology 76 (1979) 170-177
30. Reasor M.J., and Castranova V. Recovery from chlorphentermine-induced phospholipidosis in rat alveolar macrophages: biochemical and cellular features. Exp Mol Pathol 35 (1981) 359-369
31. Reasor M.J., and Walker E.R. Recovery from chlorphentermine-induced phospholipidosis in rat alveolar macrophages: morphological features. Exp Mol Pathol 35 (1981) 370-379
32. Schmid D.G., Grosche P., Bandel H., and Jung G. FTICR-mass spectrometry for high-resolution analysis in combinatorial chemistry. Biotechnol Bioeng 71 (2000-2001) 149-161
33. Soga T., Ueno Y., Naraoka H., Ohashi Y., Tomita M., and Nishioka T. Simultaneous determination of anionic intermediates for Bacillus subtilis metabolic pathways by capillary electrophoresis electrospray ionization mass spectrometry. Anal Chem 74 (2002) 2233-2239
34. Soga T., Baran R., Suematsu M., Ueno Y., Ikeda S., Sakurakawa T., et al. Differential metabolomics reveals ophthalmic acid as an oxidative stress biomarker indicating hepatic glutathione consumption. J Biol Chem 281 (2006) 16768-16776
35. Tulkens P.M. Experimental studies on nephrotoxicity of aminoglycosides at low doses. Mechanisms and perspectives. Am J Med 80 (1986) 105-114
36. Woolf L.I. Excretion of conjugated phenylacetic acid in phenylketonuria. Biochem J 49 (1951) ix-x