메뉴 건너뛰기




Volumn 5, Issue 2, 2012, Pages 301-316

The application of mass spectrometry to proteomics and metabolomics in biomarker discovery and drug development

Author keywords

Biomarker; Body fluids; Drug development; Mass spectrometry; Metabolomics; Pharmaceutical company; Proteomics

Indexed keywords

BIOLOGICAL MARKER;

EID: 84861759321     PISSN: 18744672     EISSN: 18744702     Source Type: Journal    
DOI: 10.2174/1874467211205020301     Document Type: Review
Times cited : (35)

References (178)
  • 2
    • 0036441844 scopus 로고    scopus 로고
    • The value of improving the productivity of the drug development process: Faster times and better decisions
    • DiMasi, J.A.; The value of improving the productivity of the drug development process: faster times and better decisions. Pharmacoeconomics, 2002, 20, 1-10.
    • (2002) Pharmacoeconomics , vol.20 , pp. 1-10
    • DiMasi, J.A.1
  • 3
    • 0038004636 scopus 로고    scopus 로고
    • Clinical biomarkers in drug discovery and development
    • Frank, R.; Hargreaves, R. Clinical biomarkers in drug discovery and development. Nat. Rev. Drug Discov., 2003, 2, 566-580.
    • (2003) Nat. Rev. Drug Discov , vol.2 , pp. 566-580
    • Frank, R.1    Hargreaves, R.2
  • 4
    • 62849111680 scopus 로고    scopus 로고
    • Biomarker discovery: Validation and decision-making in product development
    • Niedbala, R.S.; Mauck, C.; Harrison, P.; Doncel, G.F. Biomarker discovery: validation and decision-making in product development. Sex. Transm. Dis., 2009, 36, S76-80.
    • (2009) Sex. Transm. Dis , vol.36
    • Niedbala, R.S.1    Mauck, C.2    Harrison, P.3    Doncel, G.F.4
  • 5
    • 34548329479 scopus 로고    scopus 로고
    • The applications of biomarkers in early clinical drug development to improve decision-making processes
    • Kuhlmann, J.; Wensing, G. The applications of biomarkers in early clinical drug development to improve decision-making processes. Curr. Clin. Pharmacol., 2006, 1, 185-191.
    • (2006) Curr. Clin. Pharmacol , vol.1 , pp. 185-191
    • Kuhlmann, J.1    Wensing, G.2
  • 6
    • 41149108215 scopus 로고    scopus 로고
    • Strategic approach to fit-for-purpose biomarkers in drug development
    • Wagner, J.A. Strategic approach to fit-for-purpose biomarkers in drug development. Annu. Rev. Pharmacol. Toxicol., 2008, 48, 631-651.
    • (2008) Annu. Rev. Pharmacol. Toxicol , vol.48 , pp. 631-651
    • Wagner, J.A.1
  • 7
    • 0037380673 scopus 로고    scopus 로고
    • Biomarkers in drug discovery and development: From target identification through drug marketing
    • Colburn, W.A. Biomarkers in drug discovery and development: from target identification through drug marketing. J. Clin. Pharmacol., 2003, 43, 329-341.
    • (2003) J. Clin. Pharmacol , vol.43 , pp. 329-341
    • Colburn, W.A.1
  • 8
    • 67650639088 scopus 로고    scopus 로고
    • Chutes and ladders on the critical path: Comparative effectiveness, product value, and the use of biomarkers in drug development
    • Woodcock, J. Chutes and ladders on the critical path: comparative effectiveness, product value, and the use of biomarkers in drug development. Clin. Pharmacol. Ther., 2009, 86, 12-14.
    • (2009) Clin. Pharmacol. Ther , vol.86 , pp. 12-14
    • Woodcock, J.1
  • 9
    • 0035100888 scopus 로고    scopus 로고
    • Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework
    • Biomarkers Definitions Working Group
    • Biomarkers Definitions Working Group. Biomarkers and surrogate endpoints: preferred definitions and conceptual framework. Clin. Pharmacol. Ther., 2001, 69, 89-95.
    • (2001) Clin. Pharmacol. Ther , vol.69 , pp. 89-95
  • 11
    • 34047177929 scopus 로고    scopus 로고
    • Biomarker qualification pilot process at the US Food and Drug Administration
    • Goodsaid, F.; Frueh, F. Biomarker qualification pilot process at the US Food and Drug Administration. AAPS J., 2007, 9, E105-108.
    • (2007) AAPS J , vol.9
    • Goodsaid, F.1    Frueh, F.2
  • 12
    • 33845974419 scopus 로고    scopus 로고
    • Biomarkers and surrogate end points for fit-for-purpose development and regulatory evaluation of new drugs
    • Wagner, J.A.; Williams, S.A.; Webster, C.J. Biomarkers and surrogate end points for fit-for-purpose development and regulatory evaluation of new drugs. Clin. Pharmacol. Ther., 2007, 81, 104-107.
    • (2007) Clin. Pharmacol. Ther , vol.81 , pp. 104-107
    • Wagner, J.A.1    Williams, S.A.2    Webster, C.J.3
  • 13
    • 70449440987 scopus 로고    scopus 로고
    • The uses of biomarkers in drug development
    • Hurko, O. The uses of biomarkers in drug development. Ann. N. Y. Acad. Sci., 2009, 1180, 1-10.
    • (2009) Ann. N. Y. Acad. Sci , vol.1180 , pp. 1-10
    • Hurko, O.1
  • 14
    • 34250731324 scopus 로고    scopus 로고
    • Promises of biomarkers in drug development-a reality check
    • Marrer, E.; Dieterle, F. Promises of biomarkers in drug development-a reality check. Chem. Biol. Drug Des., 2007, 69, 381-394.
    • (2007) Chem. Biol. Drug Des , vol.69 , pp. 381-394
    • Marrer, E.1    Dieterle, F.2
  • 15
    • 21444453083 scopus 로고    scopus 로고
    • In biomarkers we trust?
    • Baker, M. In biomarkers we trust? Nat. Biotechnol., 2005, 23, 297-304.
    • (2005) Nat. Biotechnol , vol.23 , pp. 297-304
    • Baker, M.1
  • 17
    • 64149124608 scopus 로고    scopus 로고
    • Method validation of protein biomarkers in support of drug development or clinical diagnosis/prognosis
    • Lee, J.W.; Hall, M. Method validation of protein biomarkers in support of drug development or clinical diagnosis/prognosis. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 2009, 877, 1259-1271.
    • (2009) J. Chromatogr. B Analyt. Technol. Biomed. Life Sci , vol.877 , pp. 1259-1271
    • Lee, J.W.1    Hall, M.2
  • 18
    • 68249144517 scopus 로고    scopus 로고
    • "Fit-for-purpose" method validation and application of a biomarker (C-terminal telopeptides of type 1 collagen) in denosumab clinical studies
    • Wang, J.; Lee, J.; Burns, D.; Doherty, D.; Brunner, L.; Peterson, M.; DeSilva, B. "Fit-for-purpose" method validation and application of a biomarker (C-terminal telopeptides of type 1 collagen) in denosumab clinical studies. AAPS J., 2009, 11, 385-394.
    • (2009) AAPS J , vol.11 , pp. 385-394
    • Wang, J.1    Lee, J.2    Burns, D.3    Doherty, D.4    Brunner, L.5    Peterson, M.6    DeSilva, B.7
  • 19
    • 58149154725 scopus 로고    scopus 로고
    • Validation of analytic methods for biomarkers used in drug development
    • Chau, C.H.; Rixe, O.; McLeod, H.; Figg, W.D. Validation of analytic methods for biomarkers used in drug development. Clin. Cancer Res., 2008, 14, 5967-5976.
    • (2008) Clin. Cancer Res , vol.14 , pp. 5967-5976
    • Chau, C.H.1    Rixe, O.2    McLeod, H.3    Figg, W.D.4
  • 20
    • 0036399255 scopus 로고    scopus 로고
    • Overview of biomarkers and surrogate endpoints in drug development
    • Wagner, J.A. Overview of biomarkers and surrogate endpoints in drug development. Dis. Markers., 2002, 18, 41-46.
    • (2002) Dis. Markers , vol.18 , pp. 41-46
    • Wagner, J.A.1
  • 22
    • 72849113611 scopus 로고    scopus 로고
    • Biomarker qualification via public-private partnerships
    • Eck, S.L.; Paul S.M. Biomarker qualification via public-private partnerships. Clin. Pharmacol. Ther., 2010, 87, 21-23.
    • (2010) Clin. Pharmacol. Ther , vol.87 , pp. 21-23
    • Eck, S.L.1    Paul, S.M.2
  • 23
    • 77952139337 scopus 로고    scopus 로고
    • A roadmap for biomarker qualification
    • Warnock, D.G.; Peck, C.C. A roadmap for biomarker qualification. Nat. Biotechnol., 2010, 28, 444-445.
    • (2010) Nat. Biotechnol , vol.28 , pp. 444-445
    • Warnock, D.G.1    Peck, C.C.2
  • 24
    • 35148875925 scopus 로고    scopus 로고
    • Biomarkers in translational research: Focus on discovery, development and translation of protein biomarkers to clinical immunoassays
    • Rai, A.J. Biomarkers in translational research: focus on discovery, development and translation of protein biomarkers to clinical immunoassays. Expert Rev. Mol. Diagn., 2007, 7, 545-553.
    • (2007) Expert Rev. Mol. Diagn , vol.7 , pp. 545-553
    • Rai, A.J.1
  • 26
    • 74749094140 scopus 로고    scopus 로고
    • Putative molecular signatures for the imaging of prostate cancer
    • Yang, S.Y.; Adelstein, J.; Kassis, A.I. Putative molecular signatures for the imaging of prostate cancer. Expert Rev. Mol. Diagn., 2010, 10, 65-74.
    • (2010) Expert Rev. Mol. Diagn , vol.10 , pp. 65-74
    • Yang, S.Y.1    Adelstein, J.2    Kassis, A.I.3
  • 28
    • 85128759053 scopus 로고    scopus 로고
    • A list of candidate cancer biomarkers for targeted proteomics
    • Polanski, M.; Anderson, N.L. A list of candidate cancer biomarkers for targeted proteomics. Biomark. Insights, 2007, 1, 1-48.
    • (2007) Biomark. Insights , vol.1 , pp. 1-48
    • Polanski, M.1    Anderson, N.L.2
  • 29
    • 69249089272 scopus 로고    scopus 로고
    • Neuroproteomics: Understanding the molecular organization and complexity of the brain
    • Bayés, A.; Grant, S.G. Neuroproteomics: understanding the molecular organization and complexity of the brain. Nat. Rev. Neurosci., 2009, 10, 635-646.
    • (2009) Nat. Rev. Neurosci , vol.10 , pp. 635-646
    • Bayés, A.1    Grant, S.G.2
  • 30
    • 77952552373 scopus 로고    scopus 로고
    • The discovery and development of proteomic safety biomarkers for the detection of drug-induced liver toxicity
    • Amacher, D.E. The discovery and development of proteomic safety biomarkers for the detection of drug-induced liver toxicity. Toxicol. Appl. Pharmacol., 2010, 245, 134-142.
    • (2010) Toxicol. Appl. Pharmacol , vol.245 , pp. 134-142
    • Amacher, D.E.1
  • 32
    • 0037487233 scopus 로고    scopus 로고
    • Proteomics in translational cancer research: Toward an integrated approach
    • Celis, J.E.; Gromov, P. Proteomics in translational cancer research: toward an integrated approach. Cancer Cell, 2003, 3, 9-15.
    • (2003) Cancer Cell , vol.3 , pp. 9-15
    • Celis, J.E.1    Gromov, P.2
  • 33
    • 36549000204 scopus 로고    scopus 로고
    • Two-dimensional differential gel electrophoresis of rat heart proteins in ischemia and ischemia-reperfusion
    • Sakai, J.; Ishikawa, H.; Satoh, H.; Yamamoto, S.; Kojima, S.; Kanaoka, M. Two-dimensional differential gel electrophoresis of rat heart proteins in ischemia and ischemia-reperfusion. Methods Mol. Biol., 2007, 357, 33-43.
    • (2007) Methods Mol. Biol , vol.357 , pp. 33-43
    • Sakai, J.1    Ishikawa, H.2    Satoh, H.3    Yamamoto, S.4    Kojima, S.5    Kanaoka, M.6
  • 34
    • 33846934658 scopus 로고    scopus 로고
    • Opportunities and limitations of SELDI-TOF-MS in biomedical research: Practical advices
    • Poon, T.C. Opportunities and limitations of SELDI-TOF-MS in biomedical research: practical advices. Expert Rev. Proteomics, 2007, 4, 51-65.
    • (2007) Expert Rev. Proteomics , vol.4 , pp. 51-65
    • Poon, T.C.1
  • 35
    • 0037435030 scopus 로고    scopus 로고
    • Mass spectrometry-based proteomics
    • Aebersold, R.; Mann, M. Mass spectrometry-based proteomics. Nature, 2003, 422, 198-207.
    • (2003) Nature , vol.422 , pp. 198-207
    • Aebersold, R.1    Mann, M.2
  • 36
    • 33748370779 scopus 로고    scopus 로고
    • The analysis of doxorubicin resistance in human breast cancer cells using antibody microarrays
    • Smith, L.; Watson, M.B.; O'Kane, S.L.; Drew, P.J.; Lind, M.J.; Cawkwell, L. The analysis of doxorubicin resistance in human breast cancer cells using antibody microarrays. Mol. Cancer Ther., 2006, 5, 2115-2120.
    • (2006) Mol. Cancer Ther , vol.5 , pp. 2115-2120
    • Smith, L.1    Watson, M.B.2    O'Kane, S.L.3    Drew, P.J.4    Lind, M.J.5    Cawkwell, L.6
  • 37
    • 70350449049 scopus 로고    scopus 로고
    • Mass spectrometry-based clinical proteomics profiling: Current status and future directions
    • Findeisen, P.; Neumaier, M. Mass spectrometry-based clinical proteomics profiling: current status and future directions. Expert Rev. Proteomics, 2009, 6, 457-459.
    • (2009) Expert Rev. Proteomics , vol.6 , pp. 457-459
    • Findeisen, P.1    Neumaier, M.2
  • 38
    • 54749158155 scopus 로고    scopus 로고
    • Multidimensional LC separations in shotgun proteomics
    • Motoyama, A.; Yates, J.R. 3rd. Multidimensional LC separations in shotgun proteomics. Anal. Chem., 2008, 80, 7187-7193.
    • (2008) Anal. Chem , vol.80 , pp. 7187-7193
    • Motoyama, A.1    Yates III, J.R.2
  • 39
    • 33750364830 scopus 로고    scopus 로고
    • The human urinary proteome contains more than 1500 proteins, including a large proportion of membrane proteins
    • Adachi, J.; Kumar, C.; Zhang, Y.; Olsen, J.V.; Mann, M. The human urinary proteome contains more than 1500 proteins, including a large proportion of membrane proteins. Genome Biol., 2006, 7, R80.
    • (2006) Genome Biol , vol.7
    • Adachi, J.1    Kumar, C.2    Zhang, Y.3    Olsen, J.V.4    Mann, M.5
  • 41
    • 77958056802 scopus 로고    scopus 로고
    • Direct comparison of stable isotope labeling by amino acids in cell culture and spectral counting for quantitative proteomics
    • Collier, T.S.; Sarkar, P.; Franck, W.L.; Rao, B.M.; Dean, R.A.; Muddiman, D.C. Direct comparison of stable isotope labeling by amino acids in cell culture and spectral counting for quantitative proteomics. Anal Chem., 2010, 82, 8696-8702.
    • (2010) Anal Chem , vol.82 , pp. 8696-8702
    • Collier, T.S.1    Sarkar, P.2    Franck, W.L.3    Rao, B.M.4    Dean, R.A.5    Muddiman, D.C.6
  • 42
    • 77954977417 scopus 로고    scopus 로고
    • Proteome analysis of the thalamus and cerebrospinal fluid reveals glycolysis dysfunction and potential biomarkers candidates for schizophrenia
    • Martins-de-Souza, D.; Maccarrone, G.; Wobrock, T.; Zerr, I.; Gormanns, P.; Reckow, S.; Falkai, P.; Schmitt, A.; Turck, C.W. Proteome analysis of the thalamus and cerebrospinal fluid reveals glycolysis dysfunction and potential biomarkers candidates for schizophrenia. J. Psychiatr. Res., 2010, 44, 1176-1189.
    • (2010) J. Psychiatr. Res , vol.44 , pp. 1176-1189
    • Martins-de-Souza, D.1    Maccarrone, G.2    Wobrock, T.3    Zerr, I.4    Gormanns, P.5    Reckow, S.6    Falkai, P.7    Schmitt, A.8    Turck, C.W.9
  • 44
    • 77957717704 scopus 로고    scopus 로고
    • PEPPI: A peptidomic database of human protein isoforms for proteomics experiments
    • Zhou, A.; Zhang, F.; Chen, J.Y. PEPPI: a peptidomic database of human protein isoforms for proteomics experiments. BMC Bioinformatics., 2010, 11(Suppl. 6), S7.
    • (2010) BMC Bioinformatics , vol.11 , Issue.SUPPL. 6
    • Zhou, A.1    Zhang, F.2    Chen, J.Y.3
  • 45
    • 33846586667 scopus 로고    scopus 로고
    • Alternative splicing of breast cancer associated gene BRCA1 from breast cancer cell line
    • Lixia, M.; Zhijian, C.; Chao, S.; Chaojiang, G.; Congyi, Z. Alternative splicing of breast cancer associated gene BRCA1 from breast cancer cell line. J. Biochem. Mol. Biol., 2007, 40, 15-21.
    • (2007) J. Biochem. Mol. Biol , vol.40 , pp. 15-21
    • Lixia, M.1    Zhijian, C.2    Chao, S.3    Chaojiang, G.4    Congyi, Z.5
  • 47
    • 0037726623 scopus 로고    scopus 로고
    • A major step on the road to understanding a unique posttranslational modification and its role in a genetic disease
    • Baenziger, J.U. A major step on the road to understanding a unique posttranslational modification and its role in a genetic disease. Cell, 2003, 113, 421-422.
    • (2003) Cell , vol.113 , pp. 421-422
    • Baenziger, J.U.1
  • 48
    • 33745331328 scopus 로고    scopus 로고
    • Citrullination: A posttranslational modification in health and disease
    • Gyorgy, B.; Toth, E.; Tarcsa, E.; Falus, A.; Buzas, E.I. Citrullination: a posttranslational modification in health and disease. Int. J. Biochem. Cell Biol., 2006, 38, 1662-1677.
    • (2006) Int. J. Biochem. Cell Biol , vol.38 , pp. 1662-1677
    • Gyorgy, B.1    Toth, E.2    Tarcsa, E.3    Falus, A.4    Buzas, E.I.5
  • 49
    • 59149084542 scopus 로고    scopus 로고
    • Targeted proteomic strategy for clinical biomarker discovery
    • Schiess, R.; Wollscheid, B.; Aebersold, R. Targeted proteomic strategy for clinical biomarker discovery. Mol. Oncol., 2009, 3, 33-44.
    • (2009) Mol. Oncol , vol.3 , pp. 33-44
    • Schiess, R.1    Wollscheid, B.2    Aebersold, R.3
  • 50
    • 76149092539 scopus 로고    scopus 로고
    • Targeted proteomics
    • Doerr, A. Targeted proteomics. Nat. Methods, 2010, 7, 34.
    • (2010) Nat. Methods , vol.7 , pp. 34
    • Doerr, A.1
  • 51
    • 65449150181 scopus 로고    scopus 로고
    • MRM screening/biomarker discovery with linear ion trap MS: A library of human cancer-specific peptides
    • Yang, X.; Lazar, I.M. MRM screening/biomarker discovery with linear ion trap MS: a library of human cancer-specific peptides. BMC Cancer, 2009, 9, 96.
    • (2009) BMC Cancer , vol.9 , pp. 96
    • Yang, X.1    Lazar, I.M.2
  • 53
    • 38349068918 scopus 로고    scopus 로고
    • Quantitative, multiplexed assays for low abundance proteins in plasma by targeted mass spectrometry and stable isotope dilution
    • Keshishian, H.; Addona, T.; Burgess, M.; Kuhn, E.; Carr, S.A. Quantitative, multiplexed assays for low abundance proteins in plasma by targeted mass spectrometry and stable isotope dilution. Mol. Cell. Proteomics, 2007, 6, 2212-2229.
    • (2007) Mol. Cell. Proteomics , vol.6 , pp. 2212-2229
    • Keshishian, H.1    Addona, T.2    Burgess, M.3    Kuhn, E.4    Carr, S.A.5
  • 56
    • 68749094119 scopus 로고    scopus 로고
    • Full dynamic range proteome analysis of S. cerevisiae by targeted proteomics
    • Picotti, P.; Bodenmiller, B.; Mueller, L.N.; Domon, B.; Aebersold, R. Full dynamic range proteome analysis of S. cerevisiae by targeted proteomics. Cell, 2009, 138, 795-806.
    • (2009) Cell , vol.138 , pp. 795-806
    • Picotti, P.1    Bodenmiller, B.2    Mueller, L.N.3    Domon, B.4    Aebersold, R.5
  • 58
    • 33746255583 scopus 로고    scopus 로고
    • Lost in translation? Role of metabolomics in solving translational problems in drug discovery and development
    • van der Greef, J.; Adourian, A.; Muntendam, P.; McBurney, R.N. Lost in translation? Role of metabolomics in solving translational problems in drug discovery and development. Drug Discovery Today: Technologies, 2006, 3, 205-211.
    • (2006) Drug Discovery Today: Technologies , vol.3 , pp. 205-211
    • van der Greef, J.1    Adourian, A.2    Muntendam, P.3    McBurney, R.N.4
  • 59
    • 33750475205 scopus 로고    scopus 로고
    • Metabolomicsbased systems biology and personalized medicine: Moving towards n = 1 clinical trials?
    • van der Greef, J.; Hankemeier, T.; McBurney, R.N. Metabolomicsbased systems biology and personalized medicine: moving towards n = 1 clinical trials? Pharmacogenomics, 2006, 7, 1087-1094.
    • (2006) Pharmacogenomics , vol.7 , pp. 1087-1094
    • van der Greef, J.1    Hankemeier, T.2    McBurney, R.N.3
  • 61
    • 2342630549 scopus 로고    scopus 로고
    • Primer on medical genomics. Part XIV: Introduction to systems biology--a new approach to understanding disease and treatment
    • Morel, N.M.; Holland, J.M.; van der Greef, J.; Marple, E.W.; Clish, C.; Loscalzo, J.; Naylor, S. Primer on medical genomics. Part XIV: Introduction to systems biology--a new approach to understanding disease and treatment. Mayo Clin. Proc., 2004, 79, 651-658.
    • (2004) Mayo Clin. Proc , vol.79 , pp. 651-658
    • Morel, N.M.1    Holland, J.M.2    van der Greef, J.3    Marple, E.W.4    Clish, C.5    Loscalzo, J.6    Naylor, S.7
  • 63
    • 0001644020 scopus 로고    scopus 로고
    • The human plasma proteome: History, character, and diagnostic prospects
    • Anderson, N.L.; Anderson, N.G. The human plasma proteome: history, character, and diagnostic prospects. Mol. Cell. Proteomics, 2002, 1, 845-867.
    • (2002) Mol. Cell. Proteomics , vol.1 , pp. 845-867
    • Anderson, N.L.1    Anderson, N.G.2
  • 65
    • 72149100726 scopus 로고    scopus 로고
    • The dynamic range problem in the analysis of the plasma proteome
    • Hortin, G.L.; Sviridov, D. The dynamic range problem in the analysis of the plasma proteome. J. Proteomics, 2010, 73, 629-636.
    • (2010) J. Proteomics , vol.73 , pp. 629-636
    • Hortin, G.L.1    Sviridov, D.2
  • 66
    • 0017143637 scopus 로고
    • Isolation of albumin from whole human plasma and fractionation of albumin-depleted plasma
    • Travis, J.; Bowen, J.; Tewksbury, D.; Johnson, D.; Pannell, R. Isolation of albumin from whole human plasma and fractionation of albumin-depleted plasma. Biochem. J., 1976, 157, 301-306.
    • (1976) Biochem. J , vol.157 , pp. 301-306
    • Travis, J.1    Bowen, J.2    Tewksbury, D.3    Johnson, D.4    Pannell, R.5
  • 67
    • 0142244515 scopus 로고    scopus 로고
    • An approach to remove albumin for the proteomic analysis of low abundance biomarkers in human serum
    • Ahmed, N.; Barker, G.; Oliva, K.; Garfin, D.; Talmadge, K.; Georgiou, H.; Quinn, M.; Rice, G. An approach to remove albumin for the proteomic analysis of low abundance biomarkers in human serum. Proteomics, 2003, 3, 1980-1987.
    • (2003) Proteomics , vol.3 , pp. 1980-1987
    • Ahmed, N.1    Barker, G.2    Oliva, K.3    Garfin, D.4    Talmadge, K.5    Georgiou, H.6    Quinn, M.7    Rice, G.8
  • 68
    • 0041358797 scopus 로고    scopus 로고
    • Sample preparation for twodimensional gel electrophoresis
    • Shaw, M.M.; Riederer, B.M. Sample preparation for twodimensional gel electrophoresis. Proteomics, 2003, 3, 1408-1417.
    • (2003) Proteomics , vol.3 , pp. 1408-1417
    • Shaw, M.M.1    Riederer, B.M.2
  • 69
    • 4644324709 scopus 로고    scopus 로고
    • Affinity depletion of albumin from human cerebrospinal fluid using Cibacron-blue-3G-A-derivatized photopatterned copolymer in a microfluidic device
    • Li, C.; Lee, K.H. Affinity depletion of albumin from human cerebrospinal fluid using Cibacron-blue-3G-A-derivatized photopatterned copolymer in a microfluidic device. Anal. Biochem., 2004, 333, 381-388.
    • (2004) Anal. Biochem , vol.333 , pp. 381-388
    • Li, C.1    Lee, K.H.2
  • 71
    • 0037345828 scopus 로고    scopus 로고
    • A simple affinity spin tube filter method for removing high-abundant common proteins or enriching low-abundant biomarkers for serum proteomic analysis
    • Wang, Y. Y,; Cheng, P.; Chan, D.W. A simple affinity spin tube filter method for removing high-abundant common proteins or enriching low-abundant biomarkers for serum proteomic analysis. Proteomics, 2003, 3, 243-248.
    • (2003) Proteomics , vol.3 , pp. 243-248
    • Wang, Y.Y.1    Cheng, P.2    Chan, D.W.3
  • 72
    • 13244279455 scopus 로고    scopus 로고
    • Comparison of different depletion strategies for improved resolution in proteomic analysis of human serum samples
    • Björhall, K.; Miliotis, T.; Davidsson, P. Comparison of different depletion strategies for improved resolution in proteomic analysis of human serum samples. Proteomics, 2005, 5, 307-317.
    • (2005) Proteomics , vol.5 , pp. 307-317
    • Björhall, K.1    Miliotis, T.2    Davidsson, P.3
  • 75
    • 33644864034 scopus 로고    scopus 로고
    • Challenges in deriving highconfidence protein identifications from data gathered by a HUPO plasma proteome collaborative study
    • States, D.J.; Omenn, G.S.; Blackwell, T.W.; Fermin, D.; Eng, J.; Speicher, D.W.; Hanash, S.M. Challenges in deriving highconfidence protein identifications from data gathered by a HUPO plasma proteome collaborative study. Nat. Biotechnol., 2006, 24, 333-338.
    • (2006) Nat. Biotechnol , vol.24 , pp. 333-338
    • States, D.J.1    Omenn, G.S.2    Blackwell, T.W.3    Fermin, D.4    Eng, J.5    Speicher, D.W.6    Hanash, S.M.7
  • 76
    • 65349115741 scopus 로고    scopus 로고
    • A high confidence, manually validated human blood plasma protein reference set
    • Schenk, S.; Schoenhals, G.J.; de Souza, G.; Mann, M. A high confidence, manually validated human blood plasma protein reference set. BMC Med. Genomics, 2008, 1, 41.
    • (2008) BMC Med. Genomics , vol.1 , pp. 41
    • Schenk, S.1    Schoenhals, G.J.2    de Souza, G.3    Mann, M.4
  • 77
    • 65249161694 scopus 로고    scopus 로고
    • Human serum proteins fractionated by preparative partition chromatography prior to LC-ESI-MS/MS
    • Tucholska, M.; Bowden, P.; Jacks, K.; Zhu, P.; Furesz, S.; Dumbrovsky, M.; Marshall, J. Human serum proteins fractionated by preparative partition chromatography prior to LC-ESI-MS/MS. J. Proteome Res., 2009, 8, 1143-1155.
    • (2009) J. Proteome Res , vol.8 , pp. 1143-1155
    • Tucholska, M.1    Bowden, P.2    Jacks, K.3    Zhu, P.4    Furesz, S.5    Dumbrovsky, M.6    Marshall, J.7
  • 78
    • 61849133375 scopus 로고    scopus 로고
    • Absolute quantification of Creactive protein in human plasma derived from patients with epithelial ovarian cancer utilizing protein cleavage isotope dilution mass spectrometry
    • Williams, D.K.; Muddiman, D.C. Absolute quantification of Creactive protein in human plasma derived from patients with epithelial ovarian cancer utilizing protein cleavage isotope dilution mass spectrometry. J. Proteome Res., 2009, 8, 1085-1090.
    • (2009) J. Proteome Res , vol.8 , pp. 1085-1090
    • Williams, D.K.1    Muddiman, D.C.2
  • 79
    • 67449092269 scopus 로고    scopus 로고
    • Clinical quantitation of prostate-specific antigen biomarker in the low nanogram/milliliter range by conventional bore liquid chromatography-tandem mass spectrometry (multiple reaction monitoring) coupling and correlation with ELISA tests
    • Fortin, T.; Salvador, A.; Charrier, J.P.; Lenz, C.; Lacoux, X.; Morla, A, Choquet-Kastylevsky, G.; Lemoine, J. Clinical quantitation of prostate-specific antigen biomarker in the low nanogram/milliliter range by conventional bore liquid chromatography-tandem mass spectrometry (multiple reaction monitoring) coupling and correlation with ELISA tests. Mol. Cell. Proteomics, 2009, 8, 1006-1015.
    • (2009) Mol. Cell. Proteomics , vol.8 , pp. 1006-1015
    • Fortin, T.1    Salvador, A.2    Charrier, J.P.3    Lenz, C.4    Lacoux, X.5    Morla, A.6    Choquet-Kastylevsky, G.7    Lemoine, J.8
  • 80
    • 70649087115 scopus 로고    scopus 로고
    • Multiple reaction monitoring cubed for protein quantification at the low nanogram/milliliter level in nondepleted human serum
    • Fortin, T.; Salvador, A.; Charrier, J.P.; Lenz, C.; Bettsworth, F.; Lacoux, X.; Choquet-Kastylevsky, G.; Lemoine, J. Multiple reaction monitoring cubed for protein quantification at the low nanogram/milliliter level in nondepleted human serum. Anal. Chem., 2009, 81, 9343-9452.
    • (2009) Anal. Chem , vol.81 , pp. 9343-9452
    • Fortin, T.1    Salvador, A.2    Charrier, J.P.3    Lenz, C.4    Bettsworth, F.5    Lacoux, X.6    Choquet-Kastylevsky, G.7    Lemoine, J.8
  • 82
    • 4444226979 scopus 로고    scopus 로고
    • Identification and proteomic profiling of exosomes in human urine
    • Pisitkun, T.; Shen, R.F.; Knepper, M.A. Identification and proteomic profiling of exosomes in human urine. Proc. Natl. Acad. Sci. USA, 2004, 101, 13368-13373.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 13368-13373
    • Pisitkun, T.1    Shen, R.F.2    Knepper, M.A.3
  • 84
    • 70249111877 scopus 로고    scopus 로고
    • Tissue-specific, non-invasive toxicity biomarkers: Translation from preclinical safety assessment to clinical safety monitoring
    • Muller, P.Y.; Dieterle, F. Tissue-specific, non-invasive toxicity biomarkers: translation from preclinical safety assessment to clinical safety monitoring. Expert Opin. Drug Metab. Toxicol., 2009, 5, 1023-1038.
    • (2009) Expert Opin. Drug Metab. Toxicol , vol.5 , pp. 1023-1038
    • Muller, P.Y.1    Dieterle, F.2
  • 85
    • 75449102360 scopus 로고    scopus 로고
    • A guidance for renal biomarker lead optimization and use in translational pharmacodynamics
    • Ozer, J.S. A guidance for renal biomarker lead optimization and use in translational pharmacodynamics. Drug Discov. Today, 2010, 15, 142-147.
    • (2010) Drug Discov. Today , vol.15 , pp. 142-147
    • Ozer, J.S.1
  • 86
    • 77955973604 scopus 로고    scopus 로고
    • Successes achieved and challenges ahead in translating biomarkers into clinical applications
    • Tesch, G.; Amur, S.; Schousboe, J.T.; Siegel, J.N.; Lesko, L.J.; Bai, J.P. Successes achieved and challenges ahead in translating biomarkers into clinical applications. AAPS J., 2010, 12, 243-253.
    • (2010) AAPS J , vol.12 , pp. 243-253
    • Tesch, G.1    Amur, S.2    Schousboe, J.T.3    Siegel, J.N.4    Lesko, L.J.5    Bai, J.P.6
  • 90
    • 0025129636 scopus 로고
    • Laboratory investigation of cerebrospinal fluid proteins
    • Thompson, E.J.; Keir, G. Laboratory investigation of cerebrospinal fluid proteins. Ann. Clin. Biochem., 1990, 27, 425-435.
    • (1990) Ann. Clin. Biochem , vol.27 , pp. 425-435
    • Thompson, E.J.1    Keir, G.2
  • 91
    • 77950847889 scopus 로고    scopus 로고
    • Combined analysis of the glia secretome and the CSF proteome: Neuroinflammation and novel biomarkers
    • Suk, K. Combined analysis of the glia secretome and the CSF proteome: neuroinflammation and novel biomarkers. Expert Rev. Proteomics., 2010, 7, 263-274.
    • (2010) Expert Rev. Proteomics , vol.7 , pp. 263-274
    • Suk, K.1
  • 92
    • 73849107433 scopus 로고    scopus 로고
    • Proteomics of brain extracellular fluid (ECF) and cerebrospinal fluid (CSF)
    • Maurer, M.H. Proteomics of brain extracellular fluid (ECF) and cerebrospinal fluid (CSF). Mass Spectrom. Rev., 2010, 29, 17-28.
    • (2010) Mass Spectrom. Rev , vol.29 , pp. 17-28
    • Maurer, M.H.1
  • 93
    • 33847252481 scopus 로고    scopus 로고
    • CSF biomarker discovery using label-free nano-LCMS based proteomic profiling: Technical aspects
    • Huang, J.T.; McKenna, T.; Hughes, C.; Leweke, F.M.; Schwarz, E.; Bahn, S. CSF biomarker discovery using label-free nano-LCMS based proteomic profiling: technical aspects. J. Sep. Sci., 2007, 30, 214-225.
    • (2007) J. Sep. Sci , vol.30 , pp. 214-225
    • Huang, J.T.1    McKenna, T.2    Hughes, C.3    Leweke, F.M.4    Schwarz, E.5    Bahn, S.6
  • 94
    • 41549164882 scopus 로고    scopus 로고
    • Cerebrospinal fluid: Identification of diagnostic markers for schizophrenia
    • Schwarz, E.; Bahn, S. Cerebrospinal fluid: identification of diagnostic markers for schizophrenia. Expert Rev. Mol. Diagn., 2008, 8, 209-216.
    • (2008) Expert Rev. Mol. Diagn , vol.8 , pp. 209-216
    • Schwarz, E.1    Bahn, S.2
  • 98
    • 62949121626 scopus 로고    scopus 로고
    • Neuronal pentraxin receptor in cerebrospinal fluid as a potential biomarker for neurodegenerative diseases
    • Yin, G.N.; Lee, H.W.; Cho, J.Y.; Suk, K; Neuronal pentraxin receptor in cerebrospinal fluid as a potential biomarker for neurodegenerative diseases. Brain Res., 2009, 1265, 158-170.
    • (2009) Brain Res , vol.1265 , pp. 158-170
    • Yin, G.N.1    Lee, H.W.2    Cho, J.Y.3    Suk, K.4
  • 100
    • 70350495615 scopus 로고    scopus 로고
    • Glial cell-line derived neurotrophic factor (GDNF) concentrations in cerebrospinal fluid and serum of patients with early Alzheimer's disease and normal controls
    • Straten, G.; Eschweiler, G.W.; Maetzler, W.; Laske, C.; Leyhe, T. Glial cell-line derived neurotrophic factor (GDNF) concentrations in cerebrospinal fluid and serum of patients with early Alzheimer's disease and normal controls. J. Alzheimers Dis., 2009, 18, 331-337.
    • (2009) J. Alzheimers Dis , vol.18 , pp. 331-337
    • Straten, G.1    Eschweiler, G.W.2    Maetzler, W.3    Laske, C.4    Leyhe, T.5
  • 101
    • 70349731404 scopus 로고    scopus 로고
    • Biological fluid biomarkers in neurodegenerative parkinsonism
    • Eller, M.; Williams, D.R. Biological fluid biomarkers in neurodegenerative parkinsonism. Nat. Rev. Neurol., 2009, 5, 561-570.
    • (2009) Nat. Rev. Neurol , vol.5 , pp. 561-570
    • Eller, M.1    Williams, D.R.2
  • 105
  • 106
    • 33751079407 scopus 로고    scopus 로고
    • Comprehensive phenotyping in multiple sclerosis: Discovery based proteomics and the current understanding of putative biomarkers
    • O'Connor, K.C.; Roy, S.M.; Becker, C.H.; Hafler, D.A.; Kantor, A.B. Comprehensive phenotyping in multiple sclerosis: discovery based proteomics and the current understanding of putative biomarkers. Dis. Markers, 2006, 22, 213-225.
    • (2006) Dis. Markers , vol.22 , pp. 213-225
    • O'Connor, K.C.1    Roy, S.M.2    Becker, C.H.3    Hafler, D.A.4    Kantor, A.B.5
  • 107
    • 60049100278 scopus 로고    scopus 로고
    • Alteration of DBP levels in CSF of patients with MS by proteomics analysis
    • Qin, Z.; Qin, Y.; Liu, S. Alteration of DBP levels in CSF of patients with MS by proteomics analysis. Cell. Mol. Neurobiol., 2009, 29, 203-210.
    • (2009) Cell. Mol. Neurobiol , vol.29 , pp. 203-210
    • Qin, Z.1    Qin, Y.2    Liu, S.3
  • 109
    • 1542268299 scopus 로고    scopus 로고
    • Metabonomics and its role in drug development and disease diagnosis
    • Lindon, J.C.; Holmes, E.; Nicholson, J.K. Metabonomics and its role in drug development and disease diagnosis. Expert Rev. Mol. Diagn., 2004, 4, 189-199.
    • (2004) Expert Rev. Mol. Diagn , vol.4 , pp. 189-199
    • Lindon, J.C.1    Holmes, E.2    Nicholson, J.K.3
  • 110
    • 33748603444 scopus 로고    scopus 로고
    • Metabolomics: Current technologies and future trends
    • Hollywood, K.; Brison, D.R.; Goodacre, R. Metabolomics: current technologies and future trends. Proteomics, 2006, 6, 4716-4723.
    • (2006) Proteomics , vol.6 , pp. 4716-4723
    • Hollywood, K.1    Brison, D.R.2    Goodacre, R.3
  • 111
    • 27344453869 scopus 로고    scopus 로고
    • Metabolomics: From pattern recognition to biological interpretation
    • Weckwerth, W.; Morgenthal, K. Metabolomics: from pattern recognition to biological interpretation. Drug Discov. Today, 2005, 10, 1551-1558.
    • (2005) Drug Discov. Today , vol.10 , pp. 1551-1558
    • Weckwerth, W.1    Morgenthal, K.2
  • 112
    • 50149086997 scopus 로고    scopus 로고
    • Applications of metabolomics in drug discovery and development
    • Wishart, D.S. Applications of metabolomics in drug discovery and development. Drugs R. D., 2008, 9, 307-322.
    • (2008) Drugs R. D , vol.9 , pp. 307-322
    • Wishart, D.S.1
  • 113
    • 31144438390 scopus 로고    scopus 로고
    • Innovation: Rescuing drug discovery: In vivo systems pathology and systems pharmacology
    • van der Greef, J.; McBurney, R.N. Innovation: Rescuing drug discovery: in vivo systems pathology and systems pharmacology. Nat. Rev. Drug Discov., 2005, 4, 961-967.
    • (2005) Nat. Rev. Drug Discov , vol.4 , pp. 961-967
    • van der Greef, J.1    McBurney, R.N.2
  • 114
    • 3843128481 scopus 로고    scopus 로고
    • Reconstruction and validation of Saccharomyces cerevisiae iND750, a fully compartmentalized genome-scale metabolic model
    • Duarte, N.C.; Herrgård, M.J.; Palsson, B. Ø. Reconstruction and validation of Saccharomyces cerevisiae iND750, a fully compartmentalized genome-scale metabolic model. Genome Res., 2004, 14, 1298-1309.
    • (2004) Genome Res , vol.14 , pp. 1298-1309
    • Duarte, N.C.1    Herrgård, M.J.2    Palsson, B.Ø.3
  • 115
    • 14844326483 scopus 로고    scopus 로고
    • Computational prediction of human metabolic pathways from the complete human genome
    • Romero, P.; Wagg, J.; Green, M.L.; Kaiser, D.; Krummenacker, M.; Karp, P.D. Computational prediction of human metabolic pathways from the complete human genome. Genome Biol., 2005, 6, R2.
    • (2005) Genome Biol , vol.6
    • Romero, P.1    Wagg, J.2    Green, M.L.3    Kaiser, D.4    Krummenacker, M.5    Karp, P.D.6
  • 118
    • 0141653274 scopus 로고    scopus 로고
    • Global analyses of cellular lipidomes directly from crude extracts of biological samples by ESI mass spectrometry: A bridge to lipidomics
    • Han, X.; Gross, R.W. Global analyses of cellular lipidomes directly from crude extracts of biological samples by ESI mass spectrometry: a bridge to lipidomics. J. Lipid Res., 2003, 44, 1071-1079.
    • (2003) J. Lipid Res , vol.44 , pp. 1071-1079
    • Han, X.1    Gross, R.W.2
  • 119
    • 41249093623 scopus 로고    scopus 로고
    • Basic analytical systems for lipidomics by mass spectrometry in Japan
    • Taguchi, R.; Nishijima, M.; Shimizu, T. Basic analytical systems for lipidomics by mass spectrometry in Japan. Methods Enzymol., 2007, 432, 185-211.
    • (2007) Methods Enzymol , vol.432 , pp. 185-211
    • Taguchi, R.1    Nishijima, M.2    Shimizu, T.3
  • 123
    • 65249119361 scopus 로고    scopus 로고
    • Lipid mediators in health and disease: Enzymes and receptors as therapeutic targets for the regulation of immunity and inflammation
    • Shimizu, T. Lipid mediators in health and disease: enzymes and receptors as therapeutic targets for the regulation of immunity and inflammation. Annu. Rev. Pharmacol. Toxicol., 2009, 49, 123-150.
    • (2009) Annu. Rev. Pharmacol. Toxicol , vol.49 , pp. 123-150
    • Shimizu, T.1
  • 124
    • 33846977711 scopus 로고    scopus 로고
    • Metabonomics in pharmaceutical R&D
    • Lindon, J.C.; Holmes, E.; Nicholson, J.K. Metabonomics in pharmaceutical R&D. FEBS J., 2007, 274, 1140-1151.
    • (2007) FEBS J , vol.274 , pp. 1140-1151
    • Lindon, J.C.1    Holmes, E.2    Nicholson, J.K.3
  • 127
    • 77949798724 scopus 로고    scopus 로고
    • Monitoring real-time metabolism of living cells by fast two-dimensional NMR spectroscopy
    • Motta, A.; Paris, D.; Melck, D. Monitoring real-time metabolism of living cells by fast two-dimensional NMR spectroscopy. Anal. Chem., 2010, 82, 2405-2411.
    • (2010) Anal. Chem , vol.82 , pp. 2405-2411
    • Motta, A.1    Paris, D.2    Melck, D.3
  • 128
    • 27844510139 scopus 로고    scopus 로고
    • Gas chromatographic-mass spectrometric urinary metabolome analysis to study mutations of inborn errors of metabolism
    • Kuhara, T. Gas chromatographic-mass spectrometric urinary metabolome analysis to study mutations of inborn errors of metabolism. Mass Spectrom. Rev., 2005, 24, 814-827.
    • (2005) Mass Spectrom. Rev , vol.24 , pp. 814-827
    • Kuhara, T.1
  • 130
    • 34748879347 scopus 로고    scopus 로고
    • Metabolome analysis by capillary electrophoresis-mass spectrometry
    • Monton, M.R.; Soga, T. Metabolome analysis by capillary electrophoresis-mass spectrometry. J. Chromatogr. A., 2007, 1168, 237-246
    • (2007) J. Chromatogr. A , vol.1168 , pp. 237-246
    • Monton, M.R.1    Soga, T.2
  • 133
    • 77949297718 scopus 로고    scopus 로고
    • Capillary electrophoresis mass spectrometry-based saliva metabolomics identified oral, breast and pancreatic cancer-specific profiles
    • Sugimoto, M.; Wong, D.T.; Hirayama, A.; Soga, T.; Tomita, M. Capillary electrophoresis mass spectrometry-based saliva metabolomics identified oral, breast and pancreatic cancer-specific profiles. Metabolomics, 2010, 6, 78-95.
    • (2010) Metabolomics , vol.6 , pp. 78-95
    • Sugimoto, M.1    Wong, D.T.2    Hirayama, A.3    Soga, T.4    Tomita, M.5
  • 135
    • 33748784390 scopus 로고    scopus 로고
    • Simultaneous quantitative analysis of metabolites using ion-pair liquid chromatography-electrospray ionization mass spectrometry
    • Coulier, L.; Bas, R.; Jespersen, S.; Verheij, E.; van der Werf, M.J.; Hankemeier, T. Simultaneous quantitative analysis of metabolites using ion-pair liquid chromatography-electrospray ionization mass spectrometry. Anal. Chem., 2006, 78, 6573-6582.
    • (2006) Anal. Chem , vol.78 , pp. 6573-6582
    • Coulier, L.1    Bas, R.2    Jespersen, S.3    Verheij, E.4    van der Werf, M.J.5    Hankemeier, T.6
  • 136
    • 34247891778 scopus 로고    scopus 로고
    • Comprehensive analytical method for the determination of hydrophilic metabolites by high-performance liquid chromatography and mass spectrometry
    • Yoshida, H.; Mizukoshi, T.; Hirayama, K.; Miyano, H. Comprehensive analytical method for the determination of hydrophilic metabolites by high-performance liquid chromatography and mass spectrometry. J. Agric. Food Chem., 2007, 55, 551-560.
    • (2007) J. Agric. Food Chem , vol.55 , pp. 551-560
    • Yoshida, H.1    Mizukoshi, T.2    Hirayama, K.3    Miyano, H.4
  • 137
    • 77952035934 scopus 로고    scopus 로고
    • Comprehensive LC-MS E lipidomic analysis using a shotgun approach and its application to biomarker detection and identification in osteoarthritis patients
    • Castro-Perez, J.M.; Kamphorst, J.; DeGroot, J.; Lafeber, F.; Goshawk, J.; Yu, K.; Shockcor, J.P.; Vreeken, R.J.; Hankemeier, T. Comprehensive LC-MS E lipidomic analysis using a shotgun approach and its application to biomarker detection and identification in osteoarthritis patients. J. Proteome Res., 2010, 9, 2377-2389.
    • (2010) J. Proteome Res , vol.9 , pp. 2377-2389
    • Castro-Perez, J.M.1    Kamphorst, J.2    DeGroot, J.3    Lafeber, F.4    Goshawk, J.5    Yu, K.6    Shockcor, J.P.7    Vreeken, R.J.8    Hankemeier, T.9
  • 138
    • 33746606019 scopus 로고    scopus 로고
    • Separation and quantitation of water soluble cellular metabolites by hydrophilic interaction chromatographytandem mass spectrometry
    • Bajad, S.U.; Lu, W.; Kimball, E.H.; Yuan, J.; Peterson, C.; Rabinowitz, J.D. Separation and quantitation of water soluble cellular metabolites by hydrophilic interaction chromatographytandem mass spectrometry. J. Chromatogr A., 2006, 1125, 76-88.
    • (2006) J. Chromatogr A , vol.1125 , pp. 76-88
    • Bajad, S.U.1    Lu, W.2    Kimball, E.H.3    Yuan, J.4    Peterson, C.5    Rabinowitz, J.D.6
  • 140
    • 54349086814 scopus 로고    scopus 로고
    • Mass spectrometry-based neurochemical analysis: Perspectives for primate research
    • Zhang, X.; Rauch, A.; Xiao, H.; Rainer, G.; Logothetis, N.K. Mass spectrometry-based neurochemical analysis: perspectives for primate research. Expert Rev. Proteomics, 2008, 5, 641-652.
    • (2008) Expert Rev. Proteomics , vol.5 , pp. 641-652
    • Zhang, X.1    Rauch, A.2    Xiao, H.3    Rainer, G.4    Logothetis, N.K.5
  • 141
    • 52249087130 scopus 로고    scopus 로고
    • Quantitative metabolome analysis using liquid chromatography-high-resolution mass spectrometry
    • Kiefer, P.; Portais, J.C.; Vorholt, J.A. Quantitative metabolome analysis using liquid chromatography-high-resolution mass spectrometry. Anal. Biochem., 2008, 382, 94-100.
    • (2008) Anal. Biochem , vol.382 , pp. 94-100
    • Kiefer, P.1    Portais, J.C.2    Vorholt, J.A.3
  • 142
    • 34347229424 scopus 로고    scopus 로고
    • Dynamic range and mass accuracy of wide-scan direct infusion nanoelectrospray fourier transform ion cyclotron resonance mass spectrometry-based metabolomics increased by the spectral stitching method
    • Southam, A.D.; Payne, T.G.; Cooper, H.J.; Arvanitis, T.N.; Viant, M.R. Dynamic range and mass accuracy of wide-scan direct infusion nanoelectrospray fourier transform ion cyclotron resonance mass spectrometry-based metabolomics increased by the spectral stitching method. Anal Chem., 2007, 79, 4595-4602.
    • (2007) Anal Chem , vol.79 , pp. 4595-4602
    • Southam, A.D.1    Payne, T.G.2    Cooper, H.J.3    Arvanitis, T.N.4    Viant, M.R.5
  • 144
    • 77949801007 scopus 로고    scopus 로고
    • High-resolution differential ion mobility separations using helium-rich gases
    • Shvartsburg, A.A.; Danielson, W.F.; Smith, R.D. High-resolution differential ion mobility separations using helium-rich gases. Anal. Chem., 2010, 82, 2456-246
    • (2010) Anal. Chem , vol.82 , pp. 2246-2456
    • Shvartsburg, A.A.1    Danielson, W.F.2    Smith, R.D.3
  • 145
    • 34447562825 scopus 로고    scopus 로고
    • Noninvasive human metabolome analysis for differential diagnosis of inborn errors of metabolism
    • Kuhara, T. Noninvasive human metabolome analysis for differential diagnosis of inborn errors of metabolism. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 2007, 855, 42-50.
    • (2007) J. Chromatogr. B Analyt. Technol. Biomed. Life Sci , vol.855 , pp. 42-50
    • Kuhara, T.1
  • 146
    • 0037027915 scopus 로고    scopus 로고
    • Diagnosis and monitoring of inborn errors of metabolism using urease-pretreatment of urine, isotope dilution, and gas chromatography-mass spectrometry
    • Kuhara, T. Diagnosis and monitoring of inborn errors of metabolism using urease-pretreatment of urine, isotope dilution, and gas chromatography-mass spectrometry. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 2002, 781, 497-517.
    • (2002) J. Chromatogr. B Analyt. Technol. Biomed. Life Sci , vol.781 , pp. 497-517
    • Kuhara, T.1
  • 147
    • 77952818000 scopus 로고    scopus 로고
    • GC-MS and pyrimidine metabolism
    • Bryan, D.T. GC-MS and pyrimidine metabolism. Modern Drug Discovery, 2001, 4(9), 15.
    • (2001) Modern Drug Discovery , vol.4 , Issue.9 , pp. 15
    • Bryan, D.T.1
  • 148
    • 77952835222 scopus 로고    scopus 로고
    • Diagnosing Newborns
    • Randall, C.W. Diagnosing Newborns. Modern Drug Discovery, 2002, 5(4), 29-33.
    • (2002) Modern Drug Discovery , vol.5 , Issue.4 , pp. 29-33
    • Randall, C.W.1
  • 149
    • 0035811995 scopus 로고    scopus 로고
    • Simple gas chromatographic-mass spectrometric procedure for diagnosing pyrimidine degradation defects for prevention of severe anticancer side effects
    • Kuhara, T.; Ohdoi, C.; Ohse, M. Simple gas chromatographic-mass spectrometric procedure for diagnosing pyrimidine degradation defects for prevention of severe anticancer side effects. J. Chromatogr. B Biomed. Sci. Appl., 2001, 758, 61-74.
    • (2001) J. Chromatogr. B Biomed. Sci. Appl , vol.758 , pp. 61-74
    • Kuhara, T.1    Ohdoi, C.2    Ohse, M.3
  • 151
    • 0030712276 scopus 로고    scopus 로고
    • Validation of the five-drug "Pittsburgh cocktail" approach for assessment of selective regulation of drug-metabolizing enzymes
    • Frye, R.F.; Matzke, G.R.; Adedoyin, A.; Porter, J.A.; Branch, R.A. Validation of the five-drug "Pittsburgh cocktail" approach for assessment of selective regulation of drug-metabolizing enzymes. Clin. Pharmacol. Ther., 1997, 62, 365-376.
    • (1997) Clin. Pharmacol. Ther , vol.62 , pp. 365-376
    • Frye, R.F.1    Matzke, G.R.2    Adedoyin, A.3    Porter, J.A.4    Branch, R.A.5
  • 155
    • 67749140110 scopus 로고    scopus 로고
    • Dependence of mouse embryonic stem cells on threonine catabolism
    • Wang, J.; Alexander, P.; Wu, L.; Hammer, R.; Cleaver, O.; McKnight, S.L. Dependence of mouse embryonic stem cells on threonine catabolism. Science, 2009, 325, 435-439.
    • (2009) Science , vol.325 , pp. 435-439
    • Wang, J.1    Alexander, P.2    Wu, L.3    Hammer, R.4    Cleaver, O.5    McKnight, S.L.6
  • 156
    • 20544453816 scopus 로고    scopus 로고
    • Proteomics and nephrotoxicity
    • Witzmann, F.A.; Li, J. Proteomics and nephrotoxicity. Contrib. Nephrol., 2004, 141, 104-123.
    • (2004) Contrib. Nephrol , vol.141 , pp. 104-123
    • Witzmann, F.A.1    Li, J.2
  • 158
    • 36949014801 scopus 로고    scopus 로고
    • Comparison of kidney injury molecule-1 and other nephrotoxicity biomarkers in urine and kidney following acute exposure to gentamicin, mercury, and chromium
    • Zhou, Y.; Vaidya, V.S.; Brown, R.P.; Zhang, J.; Rosenzweig, B.A.; Thompson, K.L.; Miller, T. J; Bonventre, J.V.; Goering, P.L. Comparison of kidney injury molecule-1 and other nephrotoxicity biomarkers in urine and kidney following acute exposure to gentamicin, mercury, and chromium. Toxicol. Sci., 2008, 101, 159-170.
    • (2008) Toxicol. Sci , vol.101 , pp. 159-170
    • Zhou, Y.1    Vaidya, V.S.2    Brown, R.P.3    Zhang, J.4    Rosenzweig, B.A.5    Thompson, K.L.6    Miller, T.J.7    Bonventre, J.V.8    Goering, P.L.9
  • 161
    • 0036314217 scopus 로고    scopus 로고
    • Kidney Injury Molecule-1 (KIM-1): A novel biomarker for human renal proximal tubule injury
    • Han, W.K.; Bailly, V.; Abichandani, R.; Thadhani, R.; Bonventre, J.V. Kidney Injury Molecule-1 (KIM-1): a novel biomarker for human renal proximal tubule injury. Kidney Int., 2002, 62, 237-244.
    • (2002) Kidney Int , vol.62 , pp. 237-244
    • Han, W.K.1    Bailly, V.2    Abichandani, R.3    Thadhani, R.4    Bonventre, J.V.5
  • 162
    • 33644870877 scopus 로고    scopus 로고
    • Urinary kidney injury molecule-1: A sensitive quantitative biomarker for early detection of kidney tubular injury
    • Vaidya, V.S.; Ramirez, V.; Ichimura, T.; Bobadilla, N.A.; Bonventre, J.V. Urinary kidney injury molecule-1: a sensitive quantitative biomarker for early detection of kidney tubular injury. Am. J. Physiol. Renal Physiol., 2006, 290, F517-529.
    • (2006) Am. J. Physiol. Renal Physiol , vol.290
    • Vaidya, V.S.1    Ramirez, V.2    Ichimura, T.3    Bobadilla, N.A.4    Bonventre, J.V.5
  • 163
    • 4043163418 scopus 로고    scopus 로고
    • Neutrophil gelatinase-associated lipocalin: A novel early urinary biomarker for cisplatin nephrotoxicity
    • Mishra, J.; Mori, K.; Ma, Q.; Kelly, C.; Barasch, J.; Devarajan, P. Neutrophil gelatinase-associated lipocalin: a novel early urinary biomarker for cisplatin nephrotoxicity. Am. J. Nephrol., 2004, 24, 307-315.
    • (2004) Am. J. Nephrol , vol.24 , pp. 307-315
    • Mishra, J.1    Mori, K.2    Ma, Q.3    Kelly, C.4    Barasch, J.5    Devarajan, P.6
  • 166
    • 10444273269 scopus 로고    scopus 로고
    • DSerine-induced nephrotoxicity: A HPLC-TOF/MS-based metabonomics approach
    • Williams, R.E.; Major, H.; Lock, E.A.; Lenz, E.M.; Wilson, I.D. DSerine-induced nephrotoxicity: a HPLC-TOF/MS-based metabonomics approach. Toxicology, 2005, 207, 179-190.
    • (2005) Toxicology , vol.207 , pp. 179-190
    • Williams, R.E.1    Major, H.2    Lock, E.A.3    Lenz, E.M.4    Wilson, I.D.5
  • 167
    • 21444445989 scopus 로고    scopus 로고
    • 1H-NMR spectroscopy and liquid chromatography-mass spectrometry applied to the investigation of metabolic changes caused by gentamicin-induced nephrotoxicity in the rat
    • 1H-NMR spectroscopy and liquid chromatography-mass spectrometry applied to the investigation of metabolic changes caused by gentamicin-induced nephrotoxicity in the rat. Biomarkers, 2005, 10, 173-187.
    • (2005) Biomarkers , vol.10 , pp. 173-187
    • Lenz, E.M.1    Bright, J.2    Knight, R.3    Westwood, F.R.4    Davies, D.5    Major, H.6    Wilson, I.D.7
  • 168
    • 3042517107 scopus 로고    scopus 로고
    • 1H NMR and HPLC-TOF/MS: Time dependent changes in the urinary profile of endogenous metabolites as a result of nephrotoxicity
    • 1H NMR and HPLC-TOF/MS: time dependent changes in the urinary profile of endogenous metabolites as a result of nephrotoxicity. Analyst, 2004, 129, 535-541.
    • (2004) Analyst , vol.129 , pp. 535-541
    • Lenz, E.M.1    Bright, J.2    Knight, R.3    Wilson, I.D.4    Major, H.5
  • 169
    • 2442719174 scopus 로고    scopus 로고
    • Metabonomics technologies and their applications in physiological monitoring, drug safety assessment and disease diagnosis
    • Lindon, J.C.; Holmes, E.; Bollard, M.E.; Stanley, E.G.; Nicholson, J.K. Metabonomics technologies and their applications in physiological monitoring, drug safety assessment and disease diagnosis. Biomarkers, 2004, 9, 1-31.
    • (2004) Biomarkers , vol.9 , pp. 1-31
    • Lindon, J.C.1    Holmes, E.2    Bollard, M.E.3    Stanley, E.G.4    Nicholson, J.K.5
  • 170
    • 33745920161 scopus 로고    scopus 로고
    • Human amyloid-beta synthesis and clearance rates as measured in cerebrospinal fluid in vivo
    • Bateman, R.J.; Munsell, L.Y.; Morris, J.C.; Swarm, R.; Yarasheski, K.E.; Holtzman, D.M. Human amyloid-beta synthesis and clearance rates as measured in cerebrospinal fluid in vivo. Nat. Med., 2006, 12, 856-861.
    • (2006) Nat. Med , vol.12 , pp. 856-861
    • Bateman, R.J.1    Munsell, L.Y.2    Morris, J.C.3    Swarm, R.4    Yarasheski, K.E.5    Holtzman, D.M.6
  • 171
    • 34248595908 scopus 로고    scopus 로고
    • Stable isotope labeling tandem mass spectrometry (SILT) to quantify protein production and clearance rates
    • Bateman, R.J.; Munsell, L.Y.; Chen, X.; Holtzman, D.M.; Yarasheski, K.E. Stable isotope labeling tandem mass spectrometry (SILT) to quantify protein production and clearance rates. J. Am. Soc. Mass Spectrom., 2007, 18, 997-1006.
    • (2007) J. Am. Soc. Mass Spectrom , vol.18 , pp. 997-1006
    • Bateman, R.J.1    Munsell, L.Y.2    Chen, X.3    Holtzman, D.M.4    Yarasheski, K.E.5
  • 174
    • 28644439024 scopus 로고    scopus 로고
    • Metabolomics: Working toward personalized medicine
    • Bren, L. Metabolomics: working toward personalized medicine. FDA Consum., 2005, 39, 28-33.
    • (2005) FDA Consum , vol.39 , pp. 28-33
    • Bren, L.1
  • 175
    • 77954938591 scopus 로고    scopus 로고
    • Future of personalized medicine in oncology: A systems biology approach
    • Gonzalez-Angulo, A.M.; Hennessy, B.T.; Mills, G.B. Future of personalized medicine in oncology: a systems biology approach. J. Clin. Oncol., 2010, 28, 2777-2783.
    • (2010) J. Clin. Oncol , vol.28 , pp. 2777-2783
    • Gonzalez-Angulo, A.M.1    Hennessy, B.T.2    Mills, G.B.3
  • 176
    • 70149096873 scopus 로고    scopus 로고
    • Pharmacometabonomic identification of a significant host microbiome metabolic interaction affecting human drug metabolism
    • Clayton, T.A.; Baker, D.; Lindon, J.C.; Everett J.R.; Nicholson J.K. Pharmacometabonomic identification of a significant host microbiome metabolic interaction affecting human drug metabolism. Proc. Natl. Acad. Sci. USA, 2009, 106, 14728-14733.
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 14728-14733
    • Clayton, T.A.1    Baker, D.2    Lindon, J.C.3    Everett, J.R.4    Nicholson, J.K.5
  • 178


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.