Gas chromatography-mass spectrometry-based simultaneous quantitative analytical method for urinary oxysterols and bile acids in rats

Analytical Biochemistry

Volumn 408, Issue 2, 2011, Pages 242-252

  Kumar, Bhowmik Salil ^a,b   Chung, Bong Chul ^a,b   Lee, Young Joo ^c   Yi, Hong Jae ^c   Lee, Byung Hoon ^d   Jung, Byung Hwa ^a,b  

^a Korea Institute of Science and Technology   (South Korea)

^b University of Science and Technology (UST)   (South Korea)

^c Kyung Hee University   (South Korea)

^d Seoul National University   (South Korea)

Author keywords

Bile acids; GC MS (gas chromatography mass spectrometry); Hepatotoxicity; Oxysterols; Urine

Indexed keywords

MASS SPECTROMETRY; TOXICITY;

BILE ACID; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HEPATOTOXICITY; OXYSTEROLS; URINE;

GAS CHROMATOGRAPHY;

ATORVASTATIN; BILE ACID; BIOCHEMICAL MARKER; CHENODEOXYCHOLIC ACID; CHOLIC ACID; OXYSTEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE ACID METABOLISM; CONTROLLED STUDY; DERIVATIZATION; ENZYME ACTIVITY; EXTRACTION; GAS CHROMATOGRAPHY; HISTOPATHOLOGY; HYDROLYSIS; LIVER TOXICITY; MALE; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; RAT; URINE LEVEL;

RATTUS;

EID: 78149414251     PISSN: 00032697     EISSN: 10960309     Source Type: Journal    
DOI: 10.1016/j.ab.2010.09.031     Document Type: Article

References (54)

1. Lee W.M. Drug-induced hepatotoxicity. N. Engl. J. Med. 1995, 333:1118-1127.
2. Lee W.M. Drug-induced hepatotoxicity. N. Engl. J. Med. 2003, 349:474-485.
3. Navarro V.J., Senior J.R. Drug-related hepatotoxicity. N. Engl. J. Med. 2006, 354:731-739.
4. Elfaki D.A.H., Bjornsson E., Lindor K.D. Review article: nuclear receptors and liver disease-current understanding and new therapeutic implications. Aliment. Pharmacol. Ther. 2009, 30:816-825.
5. Teng S., Piquette-Miller M. Hepatoprotective role of PXR activation and MRP3 in cholic acid-induced cholestasis. Br. J. Pharmacol. 2007, 151:367-376.
6. Janowski B.A., Willy P.J., Rama Devi T., Falck J.R., Mangelsdrof D.J. An oxysterol signalling pathway mediated by the nuclear receptor LXRα. Nature 1996, 383:728-731.
7. Makishima M. Nuclear receptors as targets for drug development: regulation of cholesterol and bile acid metabolism by nuclear receptors. J. Pharmacol. Sci. 2005, 97:177-183.
8. Russell D.W., Setchell K.D.R. Bile acid biosynthesis. Biochemistry 1992, 31:1095-1104.
9. Summerfield J.A., Billing B.H., Shackletont C.H.L. Identification of bile acids in the serum and urine in cholestasis. Evidence for 6alpha-hydroxylation of bile acids in man. Biochem. J. 1976, 154:507-516.
10. Batta A.K., Salen G. Gas chromatography of bile acids. J. Chromatogr. B 1999, 723:1-16.
11. Kumar B.S., Lee Y.J., Yi H.J., Chung B.C., Jung B.H. Discovery of safety biomarkers for atorvastatin in rat urine using mass spectrometry based metabolomics combined with global and targeted approach. Anal. Chim. Acta 2010, 661:47-59.
12. Want E., Wilson I., Gika H., Theodoridis G., Plumb R.S., Shockcor J., Holmes E., Nicholson J. Global metabolic profiling procedures for urine using UPLC-MS. Nat. Protoc. 2010, 5:1005-1018.
13. Bobeldijk I., Hekman M., de Vries-van der Weij J., Coulier L., Ramaker R., Kleemann R., Kooistra T., Rubingh C., Freidig A., Verheij E. Quantitative profiling of bile acids in biofluids and tissues based on accurate mass high resolution LC-FT-MS: compound class targeting in a metabolomics workflow. J. Chromatogr. B 2008, 871:306-313.
14. Alnouti Y., Csanaky I.L., Klaassen C.D. Quantitative-profiling of bile acids and their conjugates in mouse liver, bile, plasma, and urine using LC-MS/MS. J. Chromatogr. B 2008, 873:209-217.
15. Kimura A., Suzuki M., Murai T., Kurosawa T., Tohma M., Sata M., Inoue T., Hoshiyama A., Nakashima E., Yamashita Y., Fujisawa T., Kato H. Urinary 7alpha-hydroxy-3-oxochol-4-en-24-oic and 3-oxochola-4,6-dien-24-oic acids in infants with cholestasis. J. Hepatol. 1998, 28:270-279.
16. Nittono H., Takei H., Unno A., Kimura A., Shimizu T., Kurosawa T., Tohma S., Une M. Diagnostic determination system for high-risk screening for inborn errors of bile acid metabolism based on an analysis of urinary bile acids using gas chromatography-mass spectrometry: results for 10years in Japan. Pediatr. Int. 2009, 51:535-543.
17. Ueki I., Kimura A., Nishiyori A., Chen H.L., Takei H., Nittono H., Kurosawa T. Neonatal cholestatic liver disease in an Asian patient with a homozygous mutation in the oxysterol 7alpha-hydroxylase gene. J. Pediatr. Gastroenterol. Nutr. 2008, 46:465-469.
18. Maeda K., Kimura A., Yamato Y., Matsuishi T. Perinatal bile acid metabolism: analysis of urinary unsaturated ketonic bile acids in preterm and full-term infants. Acta Paediatr. 2003, 92:216-220.
19. Kimura A., Mahara R., Inoue T., Nomura Y., Murai T., Kurosawa T., Tohma M., Noguchi K., Hoshiyama A., Fujisawa T., Kato H. Profile of urinary bile acids in infants and children: developmental pattern of excretion of unsaturated ketonic bile acids and 7beta-hydroxylated bile acids. Pediatr. Res. 1999, 45:603-609.
20. Yamaga N., Ikebuchi J., Kohara H., Ogura Y., Yamada R. Analysis of bile acids in urine specimens from healthy humans: determination of several bile acids with beta-hydroxyl and carbonyl groups. J. Biochem. 1996, 119:725-730.
21. Kimura A., Suzuki M., Murai T., Inoue T., Kato H., Hori D., Nomura Y., Yoshimura T., Kurosawa T., Tohmas M. Perinatal bile acid metabolism: analysis of urinary bile acids in pregnant women and newborns. J. Lipid Res. 1997, 38:1954-1962.
22. Mahara R., Takeshita H., Kurosawa T., Ikegawa S., Tohma M. Determination of 1β-hydroxylated bile acids and related compounds in human biological fluids by gas chromatography-mass spectrometry. Anal. Sci. 1987, 3:449-452.
23. Kaler B., Karram T., Morgan W.A., Bach P.H., Yousef I.M., Bomzon A. Are bile acids involved in the renal dysfunction of obstructive jaundice? An experimental study in bile duct ligated rats. Ren. Fail. 2004, 26:507-516.
24. Raith K., Brenner C., Farwanah H., Müller G., Eder K., Neubert R.H.H. A new LC/APCI-MS method for the determination of cholesterol oxidation products in food. J. Chromatogr. A 2005, 1067:207-211.
25. DeBarber A.E., Lütjohann D., Merkens L., Steiner R.D. Liquid chromatography-tandem mass spectrometry determination of plasma 24S-hydroxycholesterol with chromatographic separation of 25-hydroxycholesterol. Anal. Biochem. 2008, 381:151-153.
26. Burkard I., Rentsch K.M., von Eckardstein A. Determination of 24S- and 27-hydroxycholesterol in plasma by high-performance liquid chromatography-mass spectrometry. J. Lipid Res. 2004, 45:776-781.
27. Lavy U., Burstein S., Gut M., Javitt N.B. Bile acid synthesis in man. II. Determination of 7α-hydroxycholesterol, (22R)-22-hydroxycholesterol, and 26-hydroxycholesterol in human meconium. J. Lipid Res. 1977, 18:232-238.
28. Pizzoferrato L., Nicoli S., Lintas C. GC-MS characterization and quantification of sterols and cholesterol oxidation products. Chromatographia 1993, 35:269-274.
29. Dzeletovic S., Breuer O., Lund E., Diczfalusy U. Determination of cholesterol oxidation products in human plasma by isotope dilution-mass spectrometry. Anal. Biochem. 1995, 225:73-80.
30. Thelen K.M., Lütjohann D., Vesalainen R., Janatuinen T., Knuuti J., von Bergmann K., Lehtimäki T., Laaksonen R. Effect of pravastatin on plasma sterols and oxysterols in men. Eur. J. Clin. Pharmacol. 2006, 62:9-14.
31. Budzinski H., Devier M.H., Labadie P., Togola A. Analysis of hormonal steroids in fish plasma and bile by coupling solid-phase extraction to GC/MS. Anal. Bioanal. Chem. 2006, 386:1429-1439.
32. Ryu H.K., Jung B.H., Kim K.M., Yoo E.A., Woo J.T., Chung B.C. Determination of cholesterol in human hair using gas chromatography-mass spectrometry. Biomed. Chromatogr. 2006, 20:999-1003.
33. Cho S.H., Jung B.H., Lee S.H., Lee W.Y., Kong G., Chung B.C. Direct determination of nucleosides in the urine of patients with breast cancer using column-switching liquid chromatography-tandem mass spectrometry. Biomed. Chromatogr. 2006, 20:1229-1236.
34. Kassirer J.P. Clinical evaluation of kidney function-glomerular function. N. Engl. J. Med. 1971, 285:385-389.
35. Hartman H.A., Myers L.A., Evans M., Robison R.L., Engstrom R.G., Tse F.L.S. The safety evaluation of fluvastatin, an HMG-CoA reductase inhibitor, in beagle dogs and rhesus monkeys. Fundam. Appl. Toxicol. 1996, 29:48-62.
36. Walsh K.M., Albassam M.A., Clarke D.E. Subchronic toxicity of atorvastatin, a hydroxymethylglutaryl-coenzyme A reductase inhibitor, in beagle dogs. Toxicol. Pathol. 1996, 24:468-476.
37. Roda A., Piazza F., Baraldini M. Separation techniques for bile salts analysis. J. Chromatogr. B 1998, 717:263-278.
38. Levin S.J., Irvin J.L., Johnston C.G. Spectrofluorometric determination of total bile acids in bile. Anal. Chem. 1961, 33:856-860.
39. Takikawa H., Beppu T., Seyama Y. Profiles of bile acids and their glucuronide and sulphate conjugates in the serum, urine and bile from patients undergoing bile drainage. Gut 1984, 26:38-42.
40. Alnouti Y. Bile acid sulfation: a pathway of bile acid elimination and detoxification. Toxicol. Sci. 2009, 108:225-246.
41. Griffiths W.J., Hornshaw M., Woffendin G., Baker S.F., Lockhart A., Heidelberger S., Gustafsson M., Sjövall J., Wang Y. Discovering oxysterols in plasma: a window on the metabolome. J. Proteome Res. 2008, 7:3602-3612.
42. Perwaiz S., Tuchweber B., Mignault D., Gilat T., Yousef I.M. Determination of bile acids in biological fluids by liquid chromatography-electrospray tandem mass spectrometry. J. Lipid Res. 2001, 42:114-119.
43. Burkard Ines, Rentsch Katharina M., von Eckardstein Arnold Determination of 24S- and 27-hydroxycholesterol in plasma by high-performance liquid chromatography-mass spectrometry. J. Lipid Res. 2004, 45:776-781.
44. Keller S., Jahreis G. Determination of underivatised sterols and bile acid trimethyl silyl ether methyl esters by gas chromatography-mass spectrometry-single ion monitoring in faeces. J. Chromatogr. B 2004, 813:199-207.
45. Deo A.K., Bandiera S.M. Biotransformation of lithocholic acid by rat hepatic microsomes: metabolite analysis by liquid chromatography/mass spectrometry. Drug Metab. Dispos. 2008, 36:442-451.
46. Henegouwen G.P.V.B., Brandt K.-H., Eyssen H., Parmentier G. Sulphated and unsulphated bile acids in serum, bile, and urine of patients with cholestasis. Gut 1976, 17:861-869.
47. Neale G., Lewis B., Weaver V., Panveliwalla D. Serum bile acids in liver disease. Gut 1971, 12:145-152.
48. Dostal L.A., Schardein J.L., Anderson J.A. Developmental toxicity of the HMG-CoA reductase inhibitor, atorvastatin, in rats and rabbits. Teratology 1994, 50:387-394.
49. Henck J.W., Craft W.R., Black A., Colgin J., Anderson J.A. Pre- and postnatal toxicity of the HMG-CoA reductase inhibitor atorvastatin in rats. Toxicol. Sci. 1998, 41:88-99.
50. Walsh K.M., Rothwell C.E. Hepatic effects in beagle dogs administered atorvastatin, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, for 2years. Toxicol. Pathol. 1999, 27:395-401.
51. Hofmann A.F., Hagey L.R. Bile acids: chemistry, pathochemistry, biology, pathobiology, and therapeutics. Cell. Mol. Life Sci. 2008, 65:2461-2483.
52. Bloomer J.R., Allen R.M., Klatskin G. Serum bile acids in primary biliary cirrhosis. Arch. Intern. Med. 1976, 136:57-61.
53. Danielsson H. Present status of research on catabolism and excretion of cholesterol. Adv. Lipid Res. 1963, 1:335-385.
54. Russell D.W. The enzymes, regulation, and genetics of bile acid synthesis. Annu. Rev. Biochem. 2003, 72:137-174.