Discovery of common urinary biomarkers for hepatotoxicity induced by carbon tetrachloride, acetaminophen and methotrexate by mass spectrometry-based metabolomics

Journal of Applied Toxicology

Volumn 32, Issue 7, 2012, Pages 505-520

  Kumar, Bhowmik Salil ^a,b   Chung, Bong Chul ^a,b   Kwon, Oh Seung ^a   Jung, Byung Hwa ^a,b  

^a Korea Institute of Science and Technology   (South Korea)

^b University of Science and Technology (UST)   (South Korea)

Author keywords

Acetaminophen; Carbon tetrachloride; Hepatotoxicity; Mass spectrometry; Metabolomics; Methotrexate; Urinary biomarkers

Indexed keywords

11BETA HYDROXYANDROSTENEDIONE; 3 METHYLHISTIDINE; ALANINE; ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; AMINO ACID; ASPARTATE AMINOTRANSFERASE; BILE ACID; CARBON TETRACHLORIDE; CHOLIC ACID; DEHYDROCORTICOSTERONE; EPIANDROSTERONE; ESTRONE; GLYCINE; LEUCINE; LITHOCHOLIC ACID; METHOTREXATE; ORNITHINE; PARACETAMOL; STEROID; VALINE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CAPILLARY ELECTROPHORESIS; CONTROLLED STUDY; DATA BASE; DISCRIMINANT ANALYSIS; GAS CHROMATOGRAPHY; HISTOPATHOLOGY; KIDNEY CONCENTRATING CAPACITY; LIVER TOXICITY; MALE; MASS SPECTROMETER; METABOLOMICS; MULTIVARIATE ANALYSIS; NONHUMAN; PRIORITY JOURNAL; RAT; TIME OF FLIGHT MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

ACETAMINOPHEN; ALANINE TRANSAMINASE; ALKALINE PHOSPHATASE; ANIMALS; ASPARTATE AMINOTRANSFERASES; BILE ACIDS AND SALTS; BIOLOGICAL MARKERS; CARBON TETRACHLORIDE; CHROMATOGRAPHY, LIQUID; DISCRIMINANT ANALYSIS; DRUG-INDUCED LIVER INJURY; LIVER; MALE; MASS SPECTROMETRY; METABOLOME; METABOLOMICS; METHOTREXATE; MULTIVARIATE ANALYSIS; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; STEROIDS;

RATTUS;

EID: 84860239052     PISSN: 0260437X     EISSN: 10991263     Source Type: Journal    
DOI: 10.1002/jat.1746     Document Type: Article

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