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Volumn 129, Issue 2, 2015, Pages 207-220

Tau aggregation and its interplay with amyloid-β

Author keywords

Alzheimer s disease; Amyloid (A ); Frontotemporal dementia; Immunotherapy; Neurotoxicity; scFvs (single chain variable antibody fragments); Tau

Indexed keywords

ACI 24; ADUCANUMAB; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-42]; BAN 2401; BAPINEUZUMAB; BETA SECRETASE INHIBITOR; COPPER; CRENEZUMAB; ETIRACETAM; GANTENERUMAB; MEMANTINE; MONOCLONAL ANTIBODY; OMEGA 3 FATTY ACID; PLACEBO; PROTEIN KINASE FYN; QS 21; RISPERIDONE; SAR 228810; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; SOLANEZUMAB; TAU PROTEIN; UNCLASSIFIED DRUG; ZINC;

EID: 84927710653     PISSN: 00016322     EISSN: 14320533     Source Type: Journal    
DOI: 10.1007/s00401-014-1371-2     Document Type: Review
Times cited : (277)

References (112)
  • 3
    • 34548146119 scopus 로고    scopus 로고
    • Immunotherapy targeting pathological tau conformers in a tangle mouse model reduces brain pathology with associated functional improvements
    • COI: 1:CAS:528:DC%2BD2sXhtVSnsLbN
    • Asuni AA, Boutajangout A, Quartermain D, Sigurdsson EM (2007) Immunotherapy targeting pathological tau conformers in a tangle mouse model reduces brain pathology with associated functional improvements. J Neurosci Off J Soc Neurosci 27(34):9115–9129. doi:10.1523/JNEUROSCI.2361-07.2007
    • (2007) J Neurosci Off J Soc Neurosci , vol.27 , Issue.34 , pp. 9115-9129
    • Asuni, A.A.1    Boutajangout, A.2    Quartermain, D.3    Sigurdsson, E.M.4
  • 4
    • 84907343347 scopus 로고    scopus 로고
    • Axonally synthesized ATF4 transmits a neurodegenerative signal across brain regions
    • COI: 1:CAS:528:DC%2BC2cXhsV2jtLjM, PID: 25171414
    • Baleriola J, Walker CA, Jean YY, Crary JF, Troy CM, Nagy PL, Hengst U (2014) Axonally synthesized ATF4 transmits a neurodegenerative signal across brain regions. Cell 158(5):1159–1172. doi:10.1016/j.cell.2014.07.001
    • (2014) Cell , vol.158 , Issue.5 , pp. 1159-1172
    • Baleriola, J.1    Walker, C.A.2    Jean, Y.Y.3    Crary, J.F.4    Troy, C.M.5    Nagy, P.L.6    Hengst, U.7
  • 7
    • 82955194797 scopus 로고    scopus 로고
    • Tau-targeted immunization impedes progression of neurofibrillary histopathology in aged P301L tau transgenic mice
    • COI: 1:CAS:528:DC%2BC3MXhs1Oqur7K, PID: 22174735
    • Bi M, Ittner A, Ke YD, Götz J, Ittner LM (2011) Tau-targeted immunization impedes progression of neurofibrillary histopathology in aged P301L tau transgenic mice. PLoS One 6(12):e26860. doi:10.1371/journal.pone.0026860
    • (2011) PLoS One , vol.6 , Issue.12
    • Bi, M.1    Ittner, A.2    Ke, Y.D.3    Götz, J.4    Ittner, L.M.5
  • 8
    • 14644442872 scopus 로고    scopus 로고
    • Intraneuronal Abeta causes the onset of early Alzheimer’s disease-related cognitive deficits in transgenic mice
    • COI: 1:CAS:528:DC%2BD2MXis1yrs7s%3D, PID: 15748844
    • Billings LM, Oddo S, Green KN, McGaugh JL, LaFerla FM (2005) Intraneuronal Abeta causes the onset of early Alzheimer’s disease-related cognitive deficits in transgenic mice. Neuron 45(5):675–688. doi:10.1016/j.neuron.2005.01.040
    • (2005) Neuron , vol.45 , Issue.5 , pp. 675-688
    • Billings, L.M.1    Oddo, S.2    Green, K.N.3    McGaugh, J.L.4    LaFerla, F.M.5
  • 9
    • 84899019792 scopus 로고    scopus 로고
    • Amyloid-beta and tau: the trigger and bullet in Alzheimer disease pathogenesis
    • PID: 24493463
    • Bloom GS (2014) Amyloid-beta and tau: the trigger and bullet in Alzheimer disease pathogenesis. JAMA Neurol 71(4):505–508. doi:10.1001/jamaneurol.2013.5847
    • (2014) JAMA Neurol , vol.71 , Issue.4 , pp. 505-508
    • Bloom, G.S.1
  • 10
    • 77953872812 scopus 로고    scopus 로고
    • Reduction of aggregated Tau in neuronal processes but not in the cell bodies after Abeta42 immunisation in Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BC3cXns1ymurg%3D, PID: 20532897
    • Boche D, Donald J, Love S, Harris S, Neal JW, Holmes C, Nicoll JA (2010) Reduction of aggregated Tau in neuronal processes but not in the cell bodies after Abeta42 immunisation in Alzheimer’s disease. Acta Neuropathol 120(1):13–20. doi:10.1007/s00401-010-0705-y
    • (2010) Acta Neuropathol , vol.120 , Issue.1 , pp. 13-20
    • Boche, D.1    Donald, J.2    Love, S.3    Harris, S.4    Neal, J.W.5    Holmes, C.6    Nicoll, J.A.7
  • 12
    • 38349013141 scopus 로고    scopus 로고
    • Induction of tau pathology by intracerebral infusion of amyloid-beta -containing brain extract and by amyloid-beta deposition in APP x Tau transgenic mice
    • COI: 1:CAS:528:DC%2BD1cXntlartw%3D%3D, PID: 18055549
    • Bolmont T, Clavaguera F, Meyer-Luehmann M, Herzig MC, Radde R, Staufenbiel M, Lewis J, Hutton M, Tolnay M, Jucker M (2007) Induction of tau pathology by intracerebral infusion of amyloid-beta -containing brain extract and by amyloid-beta deposition in APP x Tau transgenic mice. Am J Pathol 171(6):2012–2020. doi:10.2353/ajpath.2007.070403
    • (2007) Am J Pathol , vol.171 , Issue.6 , pp. 2012-2020
    • Bolmont, T.1    Clavaguera, F.2    Meyer-Luehmann, M.3    Herzig, M.C.4    Radde, R.5    Staufenbiel, M.6    Lewis, J.7    Hutton, M.8    Tolnay, M.9    Jucker, M.10
  • 13
    • 79960563632 scopus 로고    scopus 로고
    • Passive immunization targeting pathological phospho-tau protein in a mouse model reduces functional decline and clears tau aggregates from the brain
    • COI: 1:CAS:528:DC%2BC3MXhtVSit7bM, PID: 21644996
    • Boutajangout A, Ingadottir J, Davies P, Sigurdsson EM (2011) Passive immunization targeting pathological phospho-tau protein in a mouse model reduces functional decline and clears tau aggregates from the brain. J Neurochem 118(4):658–667. doi:10.1111/j.1471-4159.2011.07337.x
    • (2011) J Neurochem , vol.118 , Issue.4 , pp. 658-667
    • Boutajangout, A.1    Ingadottir, J.2    Davies, P.3    Sigurdsson, E.M.4
  • 14
    • 78650065372 scopus 로고    scopus 로고
    • Immunotherapy targeting pathological tau prevents cognitive decline in a new tangle mouse model
    • COI: 1:CAS:528:DC%2BC3cXhsF2nurjI
    • Boutajangout A, Quartermain D, Sigurdsson EM (2010) Immunotherapy targeting pathological tau prevents cognitive decline in a new tangle mouse model. J Neurosci Off J Soc Neurosci 30(49):16559–16566. doi:10.1523/JNEUROSCI.4363-10.2010
    • (2010) J Neurosci Off J Soc Neurosci , vol.30 , Issue.49 , pp. 16559-16566
    • Boutajangout, A.1    Quartermain, D.2    Sigurdsson, E.M.3
  • 15
    • 0029013727 scopus 로고
    • Staging of Alzheimer’s disease-related neurofibrillary changes
    • COI: 1:STN:280:DyaK28%2FjsVynsg%3D%3D, PID: 7566337, discussion 278–284
    • Braak H, Braak E (1995) Staging of Alzheimer’s disease-related neurofibrillary changes. Neurobiol Aging 16(3):271–278 discussion 278–284
    • (1995) Neurobiol Aging , vol.16 , Issue.3 , pp. 271-278
    • Braak, H.1    Braak, E.2
  • 16
    • 22144443529 scopus 로고    scopus 로고
    • Functional interactions of tau and their relevance for Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BD2cXosVymurk%3D, PID: 15975055
    • Brandt R, Leschik J (2004) Functional interactions of tau and their relevance for Alzheimer’s disease. Curr Alzheimer Res 1(4):255–269
    • (2004) Curr Alzheimer Res , vol.1 , Issue.4 , pp. 255-269
    • Brandt, R.1    Leschik, J.2
  • 17
    • 84055182535 scopus 로고    scopus 로고
    • Bifunctional anti-huntingtin proteasome-directed intrabodies mediate efficient degradation of mutant huntingtin exon 1 protein fragments
    • COI: 1:CAS:528:DC%2BC38XksFKjtQ%3D%3D, PID: 22216210
    • Butler DC, Messer A (2011) Bifunctional anti-huntingtin proteasome-directed intrabodies mediate efficient degradation of mutant huntingtin exon 1 protein fragments. PLoS One 6(12):e29199. doi:10.1371/journal.pone.0029199
    • (2011) PLoS One , vol.6 , Issue.12 , pp. 29199
    • Butler, D.C.1    Messer, A.2
  • 19
    • 79953699669 scopus 로고    scopus 로고
    • Chronic intranasal treatment with an anti-Abeta(30-42) scFv antibody ameliorates amyloid pathology in a transgenic mouse model of Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BC3MXkvV2gs70%3D, PID: 21483675
    • Cattepoel S, Hanenberg M, Kulic L, Nitsch RM (2011) Chronic intranasal treatment with an anti-Abeta(30-42) scFv antibody ameliorates amyloid pathology in a transgenic mouse model of Alzheimer’s disease. PLoS One 6(4):e18296. doi:10.1371/journal.pone.0018296
    • (2011) PLoS One , vol.6 , Issue.4 , pp. 18296
    • Cattepoel, S.1    Hanenberg, M.2    Kulic, L.3    Nitsch, R.M.4
  • 20
    • 84892966799 scopus 로고    scopus 로고
    • Synergistic effects of amyloid-beta and wild-type human tau on dendritic spine loss in a floxed double transgenic model of Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BC2cXivF2lur8%3D, PID: 24440055
    • Chabrier MA, Cheng D, Castello NA, Green KN, LaFerla FM (2014) Synergistic effects of amyloid-beta and wild-type human tau on dendritic spine loss in a floxed double transgenic model of Alzheimer’s disease. Neurobiol Dis 64:107–117. doi:10.1016/j.nbd.2014.01.007
    • (2014) Neurobiol Dis , vol.64 , pp. 107-117
    • Chabrier, M.A.1    Cheng, D.2    Castello, N.A.3    Green, K.N.4    LaFerla, F.M.5
  • 21
    • 80053202160 scopus 로고    scopus 로고
    • Passive immunization with anti-Tau antibodies in two transgenic models: reduction of Tau pathology and delay of disease progression
    • COI: 1:CAS:528:DC%2BC3MXht1ajtbrJ, PID: 21841002
    • Chai X, Wu S, Murray TK, Kinley R, Cella CV, Sims H, Buckner N, Hanmer J, Davies P, O’Neill MJ, Hutton ML, Citron M (2011) Passive immunization with anti-Tau antibodies in two transgenic models: reduction of Tau pathology and delay of disease progression. J Biol Chem 286(39):34457–34467. doi:10.1074/jbc.M111.229633
    • (2011) J Biol Chem , vol.286 , Issue.39 , pp. 34457-34467
    • Chai, X.1    Wu, S.2    Murray, T.K.3    Kinley, R.4    Cella, C.V.5    Sims, H.6    Buckner, N.7    Hanmer, J.8    Davies, P.9    O’Neill, M.J.10    Hutton, M.L.11    Citron, M.12
  • 22
    • 0026778684 scopus 로고
    • Three-dimensional analysis of the structure and composition of CA3 branched dendritic spines and their synaptic relationships with mossy fiber boutons in the rat hippocampus
    • COI: 1:STN:280:DyaK3s%2FpsVekuw%3D%3D, PID: 1460112
    • Chicurel ME, Harris KM (1992) Three-dimensional analysis of the structure and composition of CA3 branched dendritic spines and their synaptic relationships with mossy fiber boutons in the rat hippocampus. J Comp Neurol 325(2):169–182. doi:10.1002/cne.903250204
    • (1992) J Comp Neurol , vol.325 , Issue.2 , pp. 169-182
    • Chicurel, M.E.1    Harris, K.M.2
  • 23
    • 84908377705 scopus 로고    scopus 로고
    • Neuronal uptake of tau/pS422 antibody and reduced progression of tau pathology in a mouse model of Alzheimer’s disease
    • Collin L, Bohrmann B, Gopfert U, Oroszlan-Szovik K, Ozmen L, Gruninger F (2014) Neuronal uptake of tau/pS422 antibody and reduced progression of tau pathology in a mouse model of Alzheimer’s disease. Brain J Neurol 137(Pt 10):2834–2846. doi:10.1093/brain/awu213
    • (2014) Brain J Neurol , vol.137 , pp. 2834-2846
    • Collin, L.1    Bohrmann, B.2    Gopfert, U.3    Oroszlan-Szovik, K.4    Ozmen, L.5    Gruninger, F.6
  • 24
    • 84890282160 scopus 로고    scopus 로고
    • Antibody uptake into neurons occurs primarily via clathrin-dependent Fcgamma receptor endocytosis and is a prerequisite for acute tau protein clearance
    • COI: 1:CAS:528:DC%2BC3sXhvFWktrrE, PID: 24163366
    • Congdon EE, Gu J, Sait HB, Sigurdsson EM (2013) Antibody uptake into neurons occurs primarily via clathrin-dependent Fcgamma receptor endocytosis and is a prerequisite for acute tau protein clearance. J Biol Chem 288(49):35452–35465. doi:10.1074/jbc.M113.491001
    • (2013) J Biol Chem , vol.288 , Issue.49 , pp. 35452-35465
    • Congdon, E.E.1    Gu, J.2    Sait, H.B.3    Sigurdsson, E.M.4
  • 26
    • 84878586555 scopus 로고    scopus 로고
    • Why size matters—balancing mitochondrial dynamics in Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BC3sXlvVCnu78%3D, PID: 23582339
    • DuBoff B, Feany M, Götz J (2013) Why size matters—balancing mitochondrial dynamics in Alzheimer’s disease. Trends Neurosci 36(6):325–335. doi:10.1016/j.tins.2013.03.002
    • (2013) Trends Neurosci , vol.36 , Issue.6 , pp. 325-335
    • DuBoff, B.1    Feany, M.2    Götz, J.3
  • 27
    • 0026070054 scopus 로고
    • Effects of injected Alzheimer beta-amyloid cores in rat brain
    • COI: 1:CAS:528:DyaK3MXmt12ls78%3D, PID: 1924295
    • Frautschy SA, Baird A, Cole GM (1991) Effects of injected Alzheimer beta-amyloid cores in rat brain. Proc Natl Acad Sci USA 88(19):8362–8366
    • (1991) Proc Natl Acad Sci USA , vol.88 , Issue.19 , pp. 8362-8366
    • Frautschy, S.A.1    Baird, A.2    Cole, G.M.3
  • 28
    • 0021256895 scopus 로고
    • Alzheimer’s disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein
    • COI: 1:CAS:528:DyaL2cXitVOntLw%3D, PID: 6375662
    • Glenner GG, Wong CW (1984) Alzheimer’s disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem Biophys Res Commun 120(3):885–890
    • (1984) Biochem Biophys Res Commun , vol.120 , Issue.3 , pp. 885-890
    • Glenner, G.G.1    Wong, C.W.2
  • 29
    • 0026088977 scopus 로고
    • Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer’s disease
    • COI: 1:CAS:528:DyaK3MXhsFyhu7k%3D, PID: 1671712
    • Goate A, Chartier-Harlin MC, Mullan M, Brown J, Crawford F, Fidani L, Giuffra L, Haynes A, Irving N, James L et al (1991) Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer’s disease. Nature 349(6311):704–706. doi:10.1038/349704a0
    • (1991) Nature , vol.349 , Issue.6311 , pp. 704-706
    • Goate, A.1    Chartier-Harlin, M.C.2    Mullan, M.3    Brown, J.4    Crawford, F.5    Fidani, L.6    Giuffra, L.7    Haynes, A.8    Irving, N.9    James, L.10
  • 30
    • 0035943436 scopus 로고    scopus 로고
    • Formation of neurofibrillary tangles in P301 l tau transgenic mice induced by Abeta 42 fibrils
    • PID: 11520988
    • Götz J, Chen F, van Dorpe J, Nitsch RM (2001) Formation of neurofibrillary tangles in P301 l tau transgenic mice induced by Abeta 42 fibrils. Science 293(5534):1491–1495. doi:10.1126/science.1062097
    • (2001) Science , vol.293 , Issue.5534 , pp. 1491-1495
    • Götz, J.1    Chen, F.2    van Dorpe, J.3    Nitsch, R.M.4
  • 31
    • 45749151056 scopus 로고    scopus 로고
    • Animal models of Alzheimer’s disease and frontotemporal dementia
    • PID: 18568014
    • Götz J, Ittner LM (2008) Animal models of Alzheimer’s disease and frontotemporal dementia. Nat Rev Neurosci 9(7):532–544. doi:10.1038/nrn2420
    • (2008) Nat Rev Neurosci , vol.9 , Issue.7 , pp. 532-544
    • Götz, J.1    Ittner, L.M.2
  • 33
  • 34
    • 0022744803 scopus 로고
    • Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology
    • COI: 1:CAS:528:DyaL28XksFyqtrg%3D, PID: 3088567
    • Grundke-Iqbal I, Iqbal K, Tung YC, Quinlan M, Wisniewski HM, Binder LI (1986) Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology. Proc Natl Acad Sci USA 83(13):4913–4917
    • (1986) Proc Natl Acad Sci USA , vol.83 , Issue.13 , pp. 4913-4917
    • Grundke-Iqbal, I.1    Iqbal, K.2    Tung, Y.C.3    Quinlan, M.4    Wisniewski, H.M.5    Binder, L.I.6
  • 35
    • 84887837879 scopus 로고    scopus 로고
    • Two novel Tau antibodies targeting the 396/404 region are primarily taken up by neurons and reduce Tau protein pathology
    • COI: 1:CAS:528:DC%2BC3sXhslyrt7fF, PID: 24089520
    • Gu J, Congdon EE, Sigurdsson EM (2013) Two novel Tau antibodies targeting the 396/404 region are primarily taken up by neurons and reduce Tau protein pathology. J Biol Chem 288(46):33081–33095. doi:10.1074/jbc.M113.494922
    • (2013) J Biol Chem , vol.288 , Issue.46 , pp. 33081-33095
    • Gu, J.1    Congdon, E.E.2    Sigurdsson, E.M.3
  • 36
    • 79955441814 scopus 로고    scopus 로고
    • Seeding of normal Tau by pathological Tau conformers drives pathogenesis of Alzheimer-like tangles
    • COI: 1:CAS:528:DC%2BC3MXltVSqu70%3D, PID: 21372138
    • Guo JL, Lee VM (2011) Seeding of normal Tau by pathological Tau conformers drives pathogenesis of Alzheimer-like tangles. J Biol Chem 286(17):15317–15331. doi:10.1074/jbc.M110.209296
    • (2011) J Biol Chem , vol.286 , Issue.17 , pp. 15317-15331
    • Guo, J.L.1    Lee, V.M.2
  • 37
    • 33751221596 scopus 로고    scopus 로고
    • Increased cholesterol in Abeta-positive nerve terminals from Alzheimer’s disease cortex
    • COI: 1:CAS:528:DC%2BD28Xht1elt7fJ, PID: 16332401
    • Gylys KH, Fein JA, Yang F, Miller CA, Cole GM (2007) Increased cholesterol in Abeta-positive nerve terminals from Alzheimer’s disease cortex. Neurobiol Aging 28(1):8–17. doi:10.1016/j.neurobiolaging.2005.10.018
    • (2007) Neurobiol Aging , vol.28 , Issue.1 , pp. 8-17
    • Gylys, K.H.1    Fein, J.A.2    Yang, F.3    Miller, C.A.4    Cole, G.M.5
  • 38
    • 85048241364 scopus 로고    scopus 로고
    • Impaired plasticity of cortical dendritic spines in P301S tau transgenic mice
    • PID: 24344647
    • Hoffmann NA, Dorostkar MM, Blumenstock S, Goedert M, Herms J (2013) Impaired plasticity of cortical dendritic spines in P301S tau transgenic mice. Acta Neuropathol Commun 1(1):82. doi:10.1186/2051-5960-1-82
    • (2013) Acta Neuropathol Commun , vol.1 , Issue.1 , pp. 82
    • Hoffmann, N.A.1    Dorostkar, M.M.2    Blumenstock, S.3    Goedert, M.4    Herms, J.5
  • 39
    • 0027197493 scopus 로고
    • Diabodies”: small bivalent and bispecific antibody fragments
    • COI: 1:CAS:528:DyaK3sXltlOjur8%3D, PID: 8341653
    • Holliger P, Prospero T, Winter G (1993) “Diabodies”: small bivalent and bispecific antibody fragments. Proc Natl Acad Sci USA 90(14):6444–6448
    • (1993) Proc Natl Acad Sci USA , vol.90 , Issue.14 , pp. 6444-6448
    • Holliger, P.1    Prospero, T.2    Winter, G.3
  • 43
    • 78751644048 scopus 로고    scopus 로고
    • Amyloid-beta and tau–a toxic pas de deux in Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BC3MXjvFeq, PID: 21193853
    • Ittner LM, Götz J (2011) Amyloid-beta and tau–a toxic pas de deux in Alzheimer’s disease. Nat Rev Neurosci 12(2):65–72. doi:10.1038/nrn2967
    • (2011) Nat Rev Neurosci , vol.12 , Issue.2 , pp. 65-72
    • Ittner, L.M.1    Götz, J.2
  • 45
    • 84906536171 scopus 로고    scopus 로고
    • Combined treatment with a BACE inhibitor and Anti-Abeta antibody gantenerumab enhances amyloid reduction in APPLondon Mice
    • COI: 1:CAS:528:DC%2BC2cXhsVynsrvI
    • Jacobsen H, Ozmen L, Caruso A, Narquizian R, Hilpert H, Jacobsen B, Terwel D, Tanghe A, Bohrmann B (2014) Combined treatment with a BACE inhibitor and Anti-Abeta antibody gantenerumab enhances amyloid reduction in APPLondon Mice. J Neurosci Off J Soc Neurosci 34(35):11621–11630. doi:10.1523/JNEUROSCI.1405-14.2014
    • (2014) J Neurosci Off J Soc Neurosci , vol.34 , Issue.35 , pp. 11621-11630
    • Jacobsen, H.1    Ozmen, L.2    Caruso, A.3    Narquizian, R.4    Hilpert, H.5    Jacobsen, B.6    Terwel, D.7    Tanghe, A.8    Bohrmann, B.9
  • 46
    • 11144356498 scopus 로고    scopus 로고
    • Dimeric amyloid beta protein rapidly accumulates in lipid rafts followed by apolipoprotein E and phosphorylated tau accumulation in the Tg2576 mouse model of Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BD2cXjsV2jtLk%3D
    • Kawarabayashi T, Shoji M, Younkin LH, Wen-Lang L, Dickson DW, Murakami T, Matsubara E, Abe K, Ashe KH, Younkin SG (2004) Dimeric amyloid beta protein rapidly accumulates in lipid rafts followed by apolipoprotein E and phosphorylated tau accumulation in the Tg2576 mouse model of Alzheimer’s disease. J Neurosci Off J Soc Neurosci 24(15):3801–3809. doi:10.1523/JNEUROSCI.5543-03.2004
    • (2004) J Neurosci Off J Soc Neurosci , vol.24 , Issue.15 , pp. 3801-3809
    • Kawarabayashi, T.1    Shoji, M.2    Younkin, L.H.3    Wen-Lang, L.4    Dickson, D.W.5    Murakami, T.6    Matsubara, E.7    Abe, K.8    Ashe, K.H.9    Younkin, S.G.10
  • 47
    • 84893763207 scopus 로고    scopus 로고
    • Molecular drivers and cortical spread of lateral entorhinal cortex dysfunction in preclinical Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BC3sXhvFOmtLzI, PID: 24362760
    • Khan UA, Liu L, Provenzano FA, Berman DE, Profaci CP, Sloan R, Mayeux R, Duff KE, Small SA (2014) Molecular drivers and cortical spread of lateral entorhinal cortex dysfunction in preclinical Alzheimer’s disease. Nat Neurosci 17(2):304–311. doi:10.1038/nn.3606
    • (2014) Nat Neurosci , vol.17 , Issue.2 , pp. 304-311
    • Khan, U.A.1    Liu, L.2    Provenzano, F.A.3    Berman, D.E.4    Profaci, C.P.5    Sloan, R.6    Mayeux, R.7    Duff, K.E.8    Small, S.A.9
  • 48
    • 33645049049 scopus 로고    scopus 로고
    • Active immunization trial in Abeta42-injected P301L tau transgenic mice
    • COI: 1:CAS:528:DC%2BD28XivVOjtb8%3D, PID: 16289870
    • Kulic L, Kurosinski P, Chen F, Tracy J, Mohajeri MH, Li H, Nitsch RM, Götz J (2006) Active immunization trial in Abeta42-injected P301L tau transgenic mice. Neurobiol Dis 22(1):50–56. doi:10.1016/j.nbd.2005.10.002
    • (2006) Neurobiol Dis , vol.22 , Issue.1 , pp. 50-56
    • Kulic, L.1    Kurosinski, P.2    Chen, F.3    Tracy, J.4    Mohajeri, M.H.5    Li, H.6    Nitsch, R.M.7    Götz, J.8
  • 49
    • 61349201380 scopus 로고    scopus 로고
    • Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers
    • COI: 1:CAS:528:DC%2BD1MXitlGksrk%3D, PID: 19242475
    • Lauren J, Gimbel DA, Nygaard HB, Gilbert JW, Strittmatter SM (2009) Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers. Nature 457(7233):1128–1132. doi:10.1038/nature07761
    • (2009) Nature , vol.457 , Issue.7233 , pp. 1128-1132
    • Lauren, J.1    Gimbel, D.A.2    Nygaard, H.B.3    Gilbert, J.W.4    Strittmatter, S.M.5
  • 50
    • 0344505849 scopus 로고    scopus 로고
    • Tau interacts with src-family non-receptor tyrosine kinases
    • COI: 1:CAS:528:DyaK1cXnvFOqtrc%3D, PID: 9763511
    • Lee G, Newman ST, Gard DL, Band H, Panchamoorthy G (1998) Tau interacts with src-family non-receptor tyrosine kinases. J Cell Sci 111(Pt 21):3167–3177
    • (1998) J Cell Sci , vol.111 , pp. 3167-3177
    • Lee, G.1    Newman, S.T.2    Gard, D.L.3    Band, H.4    Panchamoorthy, G.5
  • 52
    • 33645038471 scopus 로고    scopus 로고
    • A specific amyloid-beta protein assembly in the brain impairs memory
    • COI: 1:CAS:528:DC%2BD28XitlKgurg%3D, PID: 16541076
    • Lesne S, Koh MT, Kotilinek L, Kayed R, Glabe CG, Yang A, Gallagher M, Ashe KH (2006) A specific amyloid-beta protein assembly in the brain impairs memory. Nature 440(7082):352–357. doi:10.1038/nature04533
    • (2006) Nature , vol.440 , Issue.7082 , pp. 352-357
    • Lesne, S.1    Koh, M.T.2    Kotilinek, L.3    Kayed, R.4    Glabe, C.G.5    Yang, A.6    Gallagher, M.7    Ashe, K.H.8
  • 53
    • 33751111439 scopus 로고    scopus 로고
    • Intracranial adeno-associated virus-mediated delivery of anti-pan amyloid beta, amyloid beta40, and amyloid beta42 single-chain variable fragments attenuates plaque pathology in amyloid precursor protein mice
    • COI: 1:CAS:528:DC%2BD28Xht1ylu7bK
    • Levites Y, Jansen K, Smithson LA, Dakin R, Holloway VM, Das P, Golde TE (2006) Intracranial adeno-associated virus-mediated delivery of anti-pan amyloid beta, amyloid beta40, and amyloid beta42 single-chain variable fragments attenuates plaque pathology in amyloid precursor protein mice. J Neurosci Off J Soc Neurosci 26(46):11923–11928. doi:10.1523/JNEUROSCI.2795-06.2006
    • (2006) J Neurosci Off J Soc Neurosci , vol.26 , Issue.46 , pp. 11923-11928
    • Levites, Y.1    Jansen, K.2    Smithson, L.A.3    Dakin, R.4    Holloway, V.M.5    Das, P.6    Golde, T.E.7
  • 56
    • 84878947567 scopus 로고    scopus 로고
    • A cancer specific cell-penetrating peptide, BR2, for the efficient delivery of an scFv into cancer cells
    • COI: 1:CAS:528:DC%2BC3sXhtVantrrP, PID: 23776609
    • Lim KJ, Sung BH, Shin JR, Lee YW, da Kim J, Yang KS, Kim SC (2013) A cancer specific cell-penetrating peptide, BR2, for the efficient delivery of an scFv into cancer cells. PLoS One 8(6):e66084. doi:10.1371/journal.pone.0066084
    • (2013) PLoS One , vol.8 , Issue.6 , pp. 66084
    • Lim, K.J.1    Sung, B.H.2    Shin, J.R.3    Lee, Y.W.4    da Kim, J.5    Yang, K.S.6    Kim, S.C.7
  • 57
    • 84893529375 scopus 로고    scopus 로고
    • Profiling murine tau with 0 N, 1 N and 2 N isoform-specific antibodies in brain and peripheral organs reveals distinct subcellular localization, with the 1 N isoform being enriched in the nucleus
    • PID: 24386422
    • Liu C, Götz J (2013) Profiling murine tau with 0 N, 1 N and 2 N isoform-specific antibodies in brain and peripheral organs reveals distinct subcellular localization, with the 1 N isoform being enriched in the nucleus. PLoS One 8(12):e84849. doi:10.1371/journal.pone.0084849
    • (2013) PLoS One , vol.8 , Issue.12 , pp. 84849
    • Liu, C.1    Götz, J.2
  • 58
    • 2642578354 scopus 로고    scopus 로고
    • Single chain variable fragments against beta-amyloid (Abeta) can inhibit Abeta aggregation and prevent abeta-induced neurotoxicity
    • COI: 1:CAS:528:DC%2BD2cXjvVShurY%3D, PID: 15170333
    • Liu R, Yuan B, Emadi S, Zameer A, Schulz P, McAllister C, Lyubchenko Y, Goud G, Sierks MR (2004) Single chain variable fragments against beta-amyloid (Abeta) can inhibit Abeta aggregation and prevent abeta-induced neurotoxicity. Biochemistry 43(22):6959–6967. doi:10.1021/bi049933o
    • (2004) Biochemistry , vol.43 , Issue.22 , pp. 6959-6967
    • Liu, R.1    Yuan, B.2    Emadi, S.3    Zameer, A.4    Schulz, P.5    McAllister, C.6    Lyubchenko, Y.7    Goud, G.8    Sierks, M.R.9
  • 59
    • 84876078566 scopus 로고    scopus 로고
    • The CAMKK2-AMPK kinase pathway mediates the synaptotoxic effects of Abeta oligomers through Tau phosphorylation
    • COI: 1:CAS:528:DC%2BC3sXlvVCnur0%3D, PID: 23583109
    • Mairet-Coello G, Courchet J, Pieraut S, Courchet V, Maximov A, Polleux F (2013) The CAMKK2-AMPK kinase pathway mediates the synaptotoxic effects of Abeta oligomers through Tau phosphorylation. Neuron 78(1):94–108. doi:10.1016/j.neuron.2013.02.003
    • (2013) Neuron , vol.78 , Issue.1 , pp. 94-108
    • Mairet-Coello, G.1    Courchet, J.2    Pieraut, S.3    Courchet, V.4    Maximov, A.5    Polleux, F.6
  • 60
    • 0035057591 scopus 로고    scopus 로고
    • Neurofibrillary pathology in transgenic mice overexpressing V717F beta-amyloid precursor protein
    • COI: 1:CAS:528:DC%2BD3MXjtFKmtrw%3D, PID: 11305871
    • Masliah E, Sisk A, Mallory M, Games D (2001) Neurofibrillary pathology in transgenic mice overexpressing V717F beta-amyloid precursor protein. J Neuropathol Exp Neurol 60(4):357–368
    • (2001) J Neuropathol Exp Neurol , vol.60 , Issue.4 , pp. 357-368
    • Masliah, E.1    Sisk, A.2    Mallory, M.3    Games, D.4
  • 62
    • 0032590054 scopus 로고    scopus 로고
    • Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BD3cXhsFyrug%3D%3D, PID: 10589538
    • McLean CA, Cherny RA, Fraser FW, Fuller SJ, Smith MJ, Beyreuther K, Bush AI, Masters CL (1999) Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer’s disease. Ann Neurol 46(6):860–866
    • (1999) Ann Neurol , vol.46 , Issue.6 , pp. 860-866
    • McLean, C.A.1    Cherny, R.A.2    Fraser, F.W.3    Fuller, S.J.4    Smith, M.J.5    Beyreuther, K.6    Bush, A.I.7    Masters, C.L.8
  • 63
    • 0026794746 scopus 로고
    • Mass spectrometry of purified amyloid beta protein in Alzheimer’s disease
    • COI: 1:CAS:528:DyaK38Xls1yrsbs%3D, PID: 1512246
    • Mori H, Takio K, Ogawara M, Selkoe DJ (1992) Mass spectrometry of purified amyloid beta protein in Alzheimer’s disease. J Biol Chem 267(24):17082–17086
    • (1992) J Biol Chem , vol.267 , Issue.24 , pp. 17082-17086
    • Mori, H.1    Takio, K.2    Ogawara, M.3    Selkoe, D.J.4
  • 65
    • 0026907151 scopus 로고
    • A pathogenic mutation for probable Alzheimer’s disease in the APP gene at the N-terminus of beta-amyloid
    • COI: 1:CAS:528:DyaK38XlsVyms7o%3D, PID: 1302033
    • Mullan M, Crawford F, Axelman K, Houlden H, Lilius L, Winblad B, Lannfelt L (1992) A pathogenic mutation for probable Alzheimer’s disease in the APP gene at the N-terminus of beta-amyloid. Nat Genet 1(5):345–347. doi:10.1038/ng0892-345
    • (1992) Nat Genet , vol.1 , Issue.5 , pp. 345-347
    • Mullan, M.1    Crawford, F.2    Axelman, K.3    Houlden, H.4    Lilius, L.5    Winblad, B.6    Lannfelt, L.7
  • 66
    • 0025950987 scopus 로고
    • A mutation in the amyloid precursor protein associated with hereditary Alzheimer’s disease
    • COI: 1:CAS:528:DyaK38Xls1ykurg%3D, PID: 1925564
    • Murrell J, Farlow M, Ghetti B, Benson MD (1991) A mutation in the amyloid precursor protein associated with hereditary Alzheimer’s disease. Science 254(5028):97–99
    • (1991) Science , vol.254 , Issue.5028 , pp. 97-99
    • Murrell, J.1    Farlow, M.2    Ghetti, B.3    Benson, M.D.4
  • 67
    • 0038117796 scopus 로고    scopus 로고
    • Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline
    • COI: 1:CAS:528:DC%2BD3cXisVeiu7c%3D
    • Naslund J, Haroutunian V, Mohs R, Davis KL, Davies P, Greengard P, Buxbaum JD (2000) Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline. JAMA J Am Med Assoc 283(12):1571–1577
    • (2000) JAMA J Am Med Assoc , vol.283 , Issue.12 , pp. 1571-1577
    • Naslund, J.1    Haroutunian, V.2    Mohs, R.3    Davis, K.L.4    Davies, P.5    Greengard, P.6    Buxbaum, J.D.7
  • 68
    • 0037393454 scopus 로고    scopus 로고
    • Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report
    • COI: 1:CAS:528:DC%2BD3sXisVOmu78%3D, PID: 12640446
    • Nicoll JA, Wilkinson D, Holmes C, Steart P, Markham H, Weller RO (2003) Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report. Nat Med 9(4):448–452. doi:10.1038/nm840
    • (2003) Nat Med , vol.9 , Issue.4 , pp. 448-452
    • Nicoll, J.A.1    Wilkinson, D.2    Holmes, C.3    Steart, P.4    Markham, H.5    Weller, R.O.6
  • 70
    • 84885008285 scopus 로고    scopus 로고
    • Central amyloid-beta-specific single chain variable fragment ameliorates Abeta aggregation and neurotoxicity
    • COI: 1:CAS:528:DC%2BC3sXhsFertbbN
    • Nisbet RM, Nigro J, Breheney K, Caine J, Hattarki MK, Nuttall SD (2013) Central amyloid-beta-specific single chain variable fragment ameliorates Abeta aggregation and neurotoxicity. Protein Eng Des Sel PEDS 26(10):571–580. doi:10.1093/protein/gzt025
    • (2013) Protein Eng Des Sel PEDS , vol.26 , Issue.10 , pp. 571-580
    • Nisbet, R.M.1    Nigro, J.2    Breheney, K.3    Caine, J.4    Hattarki, M.K.5    Nuttall, S.D.6
  • 71
    • 4043167747 scopus 로고    scopus 로고
    • Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome
    • COI: 1:CAS:528:DC%2BD2cXmvFOisLk%3D, PID: 15294141
    • Oddo S, Billings L, Kesslak JP, Cribbs DH, LaFerla FM (2004) Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome. Neuron 43(3):321–332. doi:10.1016/j.neuron.2004.07.003
    • (2004) Neuron , vol.43 , Issue.3 , pp. 321-332
    • Oddo, S.1    Billings, L.2    Kesslak, J.P.3    Cribbs, D.H.4    LaFerla, F.M.5
  • 72
    • 0042697305 scopus 로고    scopus 로고
    • Triple-transgenic model of Alzheimer’s disease with plaques and tangles: intracellular Abeta and synaptic dysfunction
    • COI: 1:CAS:528:DC%2BD3sXmsFOksro%3D, PID: 12895417
    • Oddo S, Caccamo A, Shepherd JD, Murphy MP, Golde TE, Kayed R, Metherate R, Mattson MP, Akbari Y, LaFerla FM (2003) Triple-transgenic model of Alzheimer’s disease with plaques and tangles: intracellular Abeta and synaptic dysfunction. Neuron 39(3):409–421
    • (2003) Neuron , vol.39 , Issue.3 , pp. 409-421
    • Oddo, S.1    Caccamo, A.2    Shepherd, J.D.3    Murphy, M.P.4    Golde, T.E.5    Kayed, R.6    Metherate, R.7    Mattson, M.P.8    Akbari, Y.9    LaFerla, F.M.10
  • 73
    • 33846015514 scopus 로고    scopus 로고
    • Reduction of soluble Abeta and tau, but not soluble Abeta alone, ameliorates cognitive decline in transgenic mice with plaques and tangles
    • COI: 1:CAS:528:DC%2BD28XhtlagsLbL, PID: 17056594
    • Oddo S, Vasilevko V, Caccamo A, Kitazawa M, Cribbs DH, LaFerla FM (2006) Reduction of soluble Abeta and tau, but not soluble Abeta alone, ameliorates cognitive decline in transgenic mice with plaques and tangles. J Biol Chem 281(51):39413–39423. doi:10.1074/jbc.M608485200
    • (2006) J Biol Chem , vol.281 , Issue.51 , pp. 39413-39423
    • Oddo, S.1    Vasilevko, V.2    Caccamo, A.3    Kitazawa, M.4    Cribbs, D.H.5    LaFerla, F.M.6
  • 76
    • 84898678139 scopus 로고    scopus 로고
    • Extrasynaptic NMDA receptor involvement in central nervous system disorders
    • COI: 1:CAS:528:DC%2BC2cXmsFGitrg%3D, PID: 24742457
    • Parsons MP, Raymond LA (2014) Extrasynaptic NMDA receptor involvement in central nervous system disorders. Neuron 82(2):279–293. doi:10.1016/j.neuron.2014.03.030
    • (2014) Neuron , vol.82 , Issue.2 , pp. 279-293
    • Parsons, M.P.1    Raymond, L.A.2
  • 79
    • 84885961431 scopus 로고    scopus 로고
    • Systemic vaccination with anti-oligomeric monoclonal antibodies improves cognitive function by reducing Abeta deposition and tau pathology in 3xTg-AD mice
    • COI: 1:CAS:528:DC%2BC3sXht1Wlur3K, PID: 23672786
    • Rasool S, Martinez-Coria H, Wu JW, LaFerla F, Glabe CG (2013) Systemic vaccination with anti-oligomeric monoclonal antibodies improves cognitive function by reducing Abeta deposition and tau pathology in 3xTg-AD mice. J Neurochem 126(4):473–482. doi:10.1111/jnc.12305
    • (2013) J Neurochem , vol.126 , Issue.4 , pp. 473-482
    • Rasool, S.1    Martinez-Coria, H.2    Wu, J.W.3    LaFerla, F.4    Glabe, C.G.5
  • 81
    • 34248181511 scopus 로고    scopus 로고
    • Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer’s disease mouse model
    • COI: 1:CAS:528:DC%2BD2sXkvVWrtrw%3D, PID: 17478722
    • Roberson ED, Scearce-Levie K, Palop JJ, Yan F, Cheng IH, Wu T, Gerstein H, Yu GQ, Mucke L (2007) Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer’s disease mouse model. Science 316(5825):750–754. doi:10.1126/science.1141736
    • (2007) Science , vol.316 , Issue.5825 , pp. 750-754
    • Roberson, E.D.1    Scearce-Levie, K.2    Palop, J.J.3    Yan, F.4    Cheng, I.H.5    Wu, T.6    Gerstein, H.7    Yu, G.Q.8    Mucke, L.9
  • 82
    • 33749614555 scopus 로고    scopus 로고
    • Tauopathy-like abnormalities and neurologic deficits in mice immunized with neuronal tau protein
    • PID: 17030663
    • Rosenmann H, Grigoriadis N, Karussis D, Boimel M, Touloumi O, Ovadia H, Abramsky O (2006) Tauopathy-like abnormalities and neurologic deficits in mice immunized with neuronal tau protein. Arch Neurol 63(10):1459–1467. doi:10.1001/archneur.63.10.1459
    • (2006) Arch Neurol , vol.63 , Issue.10 , pp. 1459-1467
    • Rosenmann, H.1    Grigoriadis, N.2    Karussis, D.3    Boimel, M.4    Touloumi, O.5    Ovadia, H.6    Abramsky, O.7
  • 84
    • 84867645474 scopus 로고    scopus 로고
    • Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer’s disease model
    • COI: 1:CAS:528:DC%2BC38Xhs1WmsbjK, PID: 22869752
    • Sanchez PE, Zhu L, Verret L, Vossel KA, Orr AG, Cirrito JR, Devidze N, Ho K, Yu GQ, Palop JJ, Mucke L (2012) Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer’s disease model. Proc Natl Acad Sci USA 109(42):E2895–E2903. doi:10.1073/pnas.1121081109
    • (2012) Proc Natl Acad Sci USA , vol.109 , Issue.42 , pp. E2895-E2903
    • Sanchez, P.E.1    Zhu, L.2    Verret, L.3    Vossel, K.A.4    Orr, A.G.5    Cirrito, J.R.6    Devidze, N.7    Ho, K.8    Yu, G.Q.9    Palop, J.J.10    Mucke, L.11
  • 86
    • 34247611481 scopus 로고    scopus 로고
    • Synaptic alterations in CA1 in mild Alzheimer disease and mild cognitive impairment
    • COI: 1:STN:280:DC%2BD2s3mtFersg%3D%3D, PID: 17470753
    • Scheff SW, Price DA, Schmitt FA, DeKosky ST, Mufson EJ (2007) Synaptic alterations in CA1 in mild Alzheimer disease and mild cognitive impairment. Neurology 68(18):1501–1508. doi:10.1212/01.wnl.0000260698.46517.8f
    • (2007) Neurology , vol.68 , Issue.18 , pp. 1501-1508
    • Scheff, S.W.1    Price, D.A.2    Schmitt, F.A.3    DeKosky, S.T.4    Mufson, E.J.5
  • 87
    • 33747760358 scopus 로고    scopus 로고
    • Hippocampal synaptic loss in early Alzheimer’s disease and mild cognitive impairment
    • COI: 1:CAS:528:DC%2BD28XoslKrs7s%3D, PID: 16289476
    • Scheff SW, Price DA, Schmitt FA, Mufson EJ (2006) Hippocampal synaptic loss in early Alzheimer’s disease and mild cognitive impairment. Neurobiol Aging 27(10):1372–1384. doi:10.1016/j.neurobiolaging.2005.09.012
    • (2006) Neurobiol Aging , vol.27 , Issue.10 , pp. 1372-1384
    • Scheff, S.W.1    Price, D.A.2    Schmitt, F.A.3    Mufson, E.J.4
  • 90
    • 33947314641 scopus 로고    scopus 로고
    • Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway
    • COI: 1:CAS:528:DC%2BD2sXjs1Wqu7o%3D
    • Shankar GM, Bloodgood BL, Townsend M, Walsh DM, Selkoe DJ, Sabatini BL (2007) Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway. J Neurosci Off J Soc Neurosci 27(11):2866–2875. doi:10.1523/JNEUROSCI.4970-06.2007
    • (2007) J Neurosci Off J Soc Neurosci , vol.27 , Issue.11 , pp. 2866-2875
    • Shankar, G.M.1    Bloodgood, B.L.2    Townsend, M.3    Walsh, D.M.4    Selkoe, D.J.5    Sabatini, B.L.6
  • 91
    • 0031457782 scopus 로고    scopus 로고
    • Bilateral injections of amyloid-beta 25–35 into the amygdala of young Fischer rats: behavioral, neurochemical, and time dependent histopathological effects
    • COI: 1:CAS:528:DyaK1cXlslylsA%3D%3D, PID: 9461057
    • Sigurdsson EM, Lee JM, Dong XW, Hejna MJ, Lorens SA (1997) Bilateral injections of amyloid-beta 25–35 into the amygdala of young Fischer rats: behavioral, neurochemical, and time dependent histopathological effects. Neurobiol Aging 18(6):591–608
    • (1997) Neurobiol Aging , vol.18 , Issue.6 , pp. 591-608
    • Sigurdsson, E.M.1    Lee, J.M.2    Dong, X.W.3    Hejna, M.J.4    Lorens, S.A.5
  • 93
    • 0030058382 scopus 로고    scopus 로고
    • Monoclonal antibodies inhibit in vitro fibrillar aggregation of the Alzheimer beta-amyloid peptide
    • COI: 1:CAS:528:DyaK28Xjslyluw%3D%3D, PID: 8552659
    • Solomon B, Koppel R, Hanan E, Katzav T (1996) Monoclonal antibodies inhibit in vitro fibrillar aggregation of the Alzheimer beta-amyloid peptide. Proc Natl Acad Sci USA 93(1):452–455
    • (1996) Proc Natl Acad Sci USA , vol.93 , Issue.1 , pp. 452-455
    • Solomon, B.1    Koppel, R.2    Hanan, E.3    Katzav, T.4
  • 94
    • 0033756376 scopus 로고    scopus 로고
    • Overview on the structure, composition, function, development, and plasticity of hippocampal dendritic spines
    • COI: 1:STN:280:DC%2BD3M7hvFyntw%3D%3D, PID: 11075821
    • Sorra KE, Harris KM (2000) Overview on the structure, composition, function, development, and plasticity of hippocampal dendritic spines. Hippocampus 10(5):501–511. doi:10.1002/1098-1063(2000)10:5<501:AID-HIPO1>3.0.CO;2-T
    • (2000) Hippocampus , vol.10 , Issue.5 , pp. 501-511
    • Sorra, K.E.1    Harris, K.M.2
  • 95
    • 70350543879 scopus 로고    scopus 로고
    • Intrabody gene therapy ameliorates motor, cognitive, and neuropathological symptoms in multiple mouse models of Huntington’s disease
    • COI: 1:CAS:528:DC%2BD1MXhsVSmtrfM
    • Southwell AL, Ko J, Patterson PH (2009) Intrabody gene therapy ameliorates motor, cognitive, and neuropathological symptoms in multiple mouse models of Huntington’s disease. J Neurosci Off J Soc Neurosci 29(43):13589–13602. doi:10.1523/JNEUROSCI.4286-09.2009
    • (2009) J Neurosci Off J Soc Neurosci , vol.29 , Issue.43 , pp. 13589-13602
    • Southwell, A.L.1    Ko, J.2    Patterson, P.H.3
  • 96
    • 37049027122 scopus 로고    scopus 로고
    • Tau phosphorylation sites work in concert to promote neurotoxicity in vivo
    • COI: 1:CAS:528:DC%2BD2sXhsVeis7zP, PID: 17928404
    • Steinhilb ML, Dias-Santagata D, Fulga TA, Felch DL, Feany MB (2007) Tau phosphorylation sites work in concert to promote neurotoxicity in vivo. Mol Biol Cell 18(12):5060–5068. doi:10.1091/mbc.E07-04-0327
    • (2007) Mol Biol Cell , vol.18 , Issue.12 , pp. 5060-5068
    • Steinhilb, M.L.1    Dias-Santagata, D.2    Fulga, T.A.3    Felch, D.L.4    Feany, M.B.5
  • 97
    • 64049119895 scopus 로고    scopus 로고
    • NMDA receptors interact with flotillin-1 and -2, lipid raft-associated proteins
    • COI: 1:CAS:528:DC%2BD1MXksVCktrY%3D, PID: 19298817
    • Swanwick CC, Shapiro ME, Yi Z, Chang K, Wenthold RJ (2009) NMDA receptors interact with flotillin-1 and -2, lipid raft-associated proteins. FEBS Lett 583(8):1226–1230. doi:10.1016/j.febslet.2009.03.017
    • (2009) FEBS Lett , vol.583 , Issue.8 , pp. 1226-1230
    • Swanwick, C.C.1    Shapiro, M.E.2    Yi, Z.3    Chang, K.4    Wenthold, R.J.5
  • 102
    • 79952775194 scopus 로고    scopus 로고
    • Robust amyloid clearance in a mouse model of Alzheimer’s disease provides novel insights into the mechanism of amyloid-beta immunotherapy
    • COI: 1:CAS:528:DC%2BC3MXjvFWmtLg%3D
    • Wang A, Das P, Switzer RC 3rd, Golde TE, Jankowsky JL (2011) Robust amyloid clearance in a mouse model of Alzheimer’s disease provides novel insights into the mechanism of amyloid-beta immunotherapy. J Neurosci Off J Soc Neurosci 31(11):4124–4136. doi:10.1523/JNEUROSCI.5077-10.2011
    • (2011) J Neurosci Off J Soc Neurosci , vol.31 , Issue.11 , pp. 4124-4136
    • Wang, A.1    Das, P.2    Switzer, R.C.3    Golde, T.E.4    Jankowsky, J.L.5
  • 103
    • 0034006944 scopus 로고    scopus 로고
    • beta-Amyloid(1-42) binds to alpha7 nicotinic acetylcholine receptor with high affinity. Implications for Alzheimer’s disease pathology
    • COI: 1:CAS:528:DC%2BD3cXhsFKkt7w%3D, PID: 10681545
    • Wang HY, Lee DH, D’Andrea MR, Peterson PA, Shank RP, Reitz AB (2000) beta-Amyloid(1-42) binds to alpha7 nicotinic acetylcholine receptor with high affinity. Implications for Alzheimer’s disease pathology. J Biol Chem 275(8):5626–5632
    • (2000) J Biol Chem , vol.275 , Issue.8 , pp. 5626-5632
    • Wang, H.Y.1    Lee, D.H.2    D’Andrea, M.R.3    Peterson, P.A.4    Shank, R.P.5    Reitz, A.B.6
  • 104
    • 0033624509 scopus 로고    scopus 로고
    • Amyloid peptide Abeta(1-42) binds selectively and with picomolar affinity to alpha7 nicotinic acetylcholine receptors
    • COI: 1:CAS:528:DC%2BD3cXmtFyrs7Y%3D, PID: 10936198
    • Wang HY, Lee DH, Davis CB, Shank RP (2000) Amyloid peptide Abeta(1-42) binds selectively and with picomolar affinity to alpha7 nicotinic acetylcholine receptors. J Neurochem 75(3):1155–1161
    • (2000) J Neurochem , vol.75 , Issue.3 , pp. 1155-1161
    • Wang, H.Y.1    Lee, D.H.2    Davis, C.B.3    Shank, R.P.4
  • 105
    • 67649363905 scopus 로고    scopus 로고
    • Amyloid reduction by amyloid-beta vaccination also reduces mouse tau pathology and protects from neuron loss in two mouse models of Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BD1MXotFKgtL8%3D
    • Wilcock DM, Gharkholonarehe N, Van Nostrand WE, Davis J, Vitek MP, Colton CA (2009) Amyloid reduction by amyloid-beta vaccination also reduces mouse tau pathology and protects from neuron loss in two mouse models of Alzheimer’s disease. J Neurosci Off J Soc Neurosci 29(25):7957–7965. doi:10.1523/JNEUROSCI.1339-09.2009
    • (2009) J Neurosci Off J Soc Neurosci , vol.29 , Issue.25 , pp. 7957-7965
    • Wilcock, D.M.1    Gharkholonarehe, N.2    Van Nostrand, W.E.3    Davis, J.4    Vitek, M.P.5    Colton, C.A.6
  • 108
    • 84885783467 scopus 로고    scopus 로고
    • Anti-tau antibodies that block tau aggregate seeding in vitro markedly decrease pathology and improve cognition in vivo
    • COI: 1:CAS:528:DC%2BC3sXhsFems73N, PID: 24075978
    • Yanamandra K, Kfoury N, Jiang H, Mahan TE, Ma S, Maloney SE, Wozniak DF, Diamond MI, Holtzman DM (2013) Anti-tau antibodies that block tau aggregate seeding in vitro markedly decrease pathology and improve cognition in vivo. Neuron 80(2):402–414. doi:10.1016/j.neuron.2013.07.046
    • (2013) Neuron , vol.80 , Issue.2 , pp. 402-414
    • Yanamandra, K.1    Kfoury, N.2    Jiang, H.3    Mahan, T.E.4    Ma, S.5    Maloney, S.E.6    Wozniak, D.F.7    Diamond, M.I.8    Holtzman, D.M.9
  • 109
    • 84904490723 scopus 로고    scopus 로고
    • Highly efficient targeted mutagenesis in one-cell mouse embryos mediated by the TALEN and CRISPR/Cas systems
    • PID: 25027812
    • Yasue A, Mitsui SN, Watanabe T, Sakuma T, Oyadomari S, Yamamoto T, Noji S, Mito T, Tanaka E (2014) Highly efficient targeted mutagenesis in one-cell mouse embryos mediated by the TALEN and CRISPR/Cas systems. Sci Rep 4:5705. doi:10.1038/srep05705
    • (2014) Sci Rep , vol.4 , pp. 5705
    • Yasue, A.1    Mitsui, S.N.2    Watanabe, T.3    Sakuma, T.4    Oyadomari, S.5    Yamamoto, T.6    Noji, S.7    Mito, T.8    Tanaka, E.9
  • 110
    • 84857676337 scopus 로고    scopus 로고
    • A critical role for the PAR-1/MARK-tau axis in mediating the toxic effects of Abeta on synapses and dendritic spines
    • COI: 1:CAS:528:DC%2BC38XivVeisrs%3D, PID: 22156579
    • Yu W, Polepalli J, Wagh D, Rajadas J, Malenka R, Lu B (2012) A critical role for the PAR-1/MARK-tau axis in mediating the toxic effects of Abeta on synapses and dendritic spines. Hum Mol Genet 21(6):1384–1390. doi:10.1093/hmg/ddr576
    • (2012) Hum Mol Genet , vol.21 , Issue.6 , pp. 1384-1390
    • Yu, W.1    Polepalli, J.2    Wagh, D.3    Rajadas, J.4    Malenka, R.5    Lu, B.6
  • 112
    • 77956587739 scopus 로고    scopus 로고
    • Abeta oligomers cause localized Ca(2 +) elevation, missorting of endogenous Tau into dendrites, Tau phosphorylation, and destruction of microtubules and spines
    • COI: 1:CAS:528:DC%2BC3cXhtF2qsLnK
    • Zempel H, Thies E, Mandelkow E, Mandelkow EM (2010) Abeta oligomers cause localized Ca(2 +) elevation, missorting of endogenous Tau into dendrites, Tau phosphorylation, and destruction of microtubules and spines. J Neurosci Off J Soc Neurosci 30(36):11938–11950. doi:10.1523/JNEUROSCI.2357-10.2010
    • (2010) J Neurosci Off J Soc Neurosci , vol.30 , Issue.36 , pp. 11938-11950
    • Zempel, H.1    Thies, E.2    Mandelkow, E.3    Mandelkow, E.M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.