Two novel Tau antibodies targeting the 396/404 region are primarily taken up by neurons and reduce Tau protein pathology

Journal of Biological Chemistry

Volumn 288, Issue 46, 2013, Pages 33081-33095

  Gu, Jiaping ^a   Congdon, Erin E ^a   Sigurdsson, Einar M ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE; BINDING PROFILES; BRAIN SLICE CULTURES; COGNITIVE DECLINE; HYPERPHOSPHORYLATED; MECHANISTIC STUDIES; MONOCLONAL ANTIBODIES (MABS); PASSIVE IMMUNIZATION;

MOLECULAR BIOLOGY; MONOCLONAL ANTIBODIES; NEURODEGENERATIVE DISEASES; PATHOLOGY; PROTEINS;

NEURONS;

BIOLOGICAL MARKER; EPITOPE; IMMUNOGLOBULIN F(AB) FRAGMENT; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 4E6G7; MONOCLONAL ANTIBODY 6B2G12; TAU PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ANTIGEN ANTIBODY REACTION; ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; BINDING SITE; BRAIN SLICE; CONTROLLED STUDY; DRUG MECHANISM; DRUG TARGETING; DRUG TRANSPORT; INTRACELLULAR TRANSPORT; MICROGLIA; MOLECULAR PATHOLOGY; MOUSE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION;

ALZHEIMER DISEASE; ANTIBODIES; AUTOPHAGOSOMES; ENDOSOMES; IMMUNOTHERAPY; LYSOSOMES; PHOSPHORYLATION; TAU;

ALZHEIMER DISEASE; ANIMALS; ANTIBODIES, MONOCLONAL, MURINE-DERIVED; ENDOSOMES; IMMUNOGLOBULIN FAB FRAGMENTS; LYSOSOMES; MICE; MICE, TRANSGENIC; MODELS, BIOLOGICAL; NEURONS; PHOSPHORYLATION; TAU PROTEINS;

EID: 84887837879     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.494922     Document Type: Article

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