Central amyloid-β-specific single chain variable fragment ameliorates Aβ aggregation and neurotoxicity

Protein Engineering, Design and Selection

Volumn 26, Issue 10, 2013, Pages 571-580

  Nisbet, R M ^a   Nigro, J ^a   Breheney, K ^a   Caine, J ^a   Hattarki, M K ^a   Nuttall, S D ^a  

^a CSIRO   (Australia)

Author keywords

Alzheimer's disease; amyloid beta; immunotherapy; single chain antibody

Indexed keywords

ALZHEIMER'S DISEASE; AMYLOID BETAS; BUILDING BLOCKES; FUNCTIONALIZATIONS; IMMUNOTHERAPY; SINGLE CHAIN VARIABLE FRAGMENTS; SINGLE-CHAIN ANTIBODIES; THERAPEUTIC ANTIBODIES;

CELL CULTURE; CHAINS; GLYCOPROTEINS; MONOCLONAL ANTIBODIES; NEURODEGENERATIVE DISEASES;

TOXICITY;

AMYLOID BETA PROTEIN[1-42]; IMMUNOGLOBULIN F(AB) FRAGMENT; LACTATE DEHYDROGENASE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 1E8; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; THIOFLAVINE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BRAIN CELL CULTURE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; EMBRYO; ENZYME LINKED IMMUNOSORBENT ASSAY; IN VITRO STUDY; MOUSE; NEUROTOXICITY; NONHUMAN; PHEOCHROMOCYTOMA CELL; PRIORITY JOURNAL; PROTEIN AGGREGATION; RAT; TRANSMISSION ELECTRON MICROSCOPY;

ALZHEIMER'S DISEASE; AMYLOID-BETA; IMMUNOTHERAPY; SINGLE CHAIN ANTIBODY;

AMINO ACID SEQUENCE; AMYLOID BETA-PEPTIDES; ANIMALS; ANTIBODY SPECIFICITY; CELL DIFFERENTIATION; FEMALE; MICE; MOLECULAR SEQUENCE DATA; NEURONS; PC12 CELLS; PEPTIDE FRAGMENTS; PREGNANCY; PROTEIN ENGINEERING; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, SECONDARY; RATS; RECOMBINANT PROTEINS; SINGLE-CHAIN ANTIBODIES;

EID: 84885008285     PISSN: 17410126     EISSN: 17410134     Source Type: Journal    
DOI: 10.1093/protein/gzt025     Document Type: Article

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