Intracranial adeno-associated virus-mediated delivery of anti-pan amyloid β, amyloid β40, and amyloid β42 single-chain variable fragments attenuates plaque pathology in amyloid precursor protein mice

Journal of Neuroscience

Volumn 26, Issue 46, 2006, Pages 11923-11928

  Levites, Yona ^a   Jansen, Karen ^a   Smithson, Lisa A ^a   Dakin, Rachel ^a   Holloway, Vallie M ^a   Das, Pritam ^a   Golde, Todd E ^a,b  

^a MAYO CLINIC   (United States)

^b MAYO GRADUATE SCHOOL   (United States)

Author keywords

Adeno associated virus; Alzheimer's disease; Amyloid; A ; Immunotherapy; Single chain variable fragments

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; RECOMBINANT PROTEIN; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY;

ALZHEIMER DISEASE; ARTICLE; BRAIN VENTRICLE; DRUG DELIVERY SYSTEM; GENE DELIVERY SYSTEM; IMMUNOTHERAPY; MOUSE; NONHUMAN; PARVOVIRUS VECTOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; VIRUS VECTOR;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; ANIMALS, NEWBORN; ANTIBODIES; BRAIN; DEPENDOVIRUS; DISEASE MODELS, ANIMAL; FEMALE; GENE THERAPY; IMMUNOGLOBULIN VARIABLE REGION; INJECTIONS, INTRAVENTRICULAR; MALE; MICE; MICE, MUTANT STRAINS; MICE, TRANSGENIC; NEURONS; PEPTIDE FRAGMENTS; SENILE PLAQUES; TREATMENT OUTCOME;

EID: 33751111439     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2795-06.2006     Document Type: Article

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