A Cancer Specific Cell-Penetrating Peptide, BR2, for the Efficient Delivery of an scFv into Cancer Cells

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  Lim, Ki Jung ^a   Sung, Bong Hyun ^b   Shin, Ju Ri ^a   Lee, Young Woong ^a   Kim, Da Jung ^a   Yang, Kyung Seok ^a   Kim, Sun Chang ^a  

^a Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

^b Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PENETRATING PEPTIDE; GANGLIOSIDE; GLYCINE; HYBRID PROTEIN; K RAS PROTEIN; PROTEIN BR2; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; TRANSACTIVATOR PROTEIN; UNCLASSIFIED DRUG; VALINE;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL MEMBRANE TRANSPORT; CELL SPECIFICITY; CELL STRAIN HCT116; CYTOTOXICITY; HUMAN; HUMAN CELL; PINOCYTOSIS; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; TARGET CELL;

APOPTOSIS; BLOTTING, WESTERN; CELL PROLIFERATION; CELL-PENETRATING PEPTIDES; ENDOCYTOSIS; HCT116 CELLS; HELA CELLS; HEMOLYSIS; HUMANS; MICROSCOPY, CONFOCAL; SINGLE-CHAIN ANTIBODIES;

EID: 84878947567     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0066084     Document Type: Article

References (47)

1. Martin I, Teixido M, Giralt E, (2010) Building cell selectivity into CPP-mediated strategies. Pharmaceuticals 3: 1456-1490.
2. Torchilin V, (2008) Intracellular delivery of protein and peptide therapeutics. Drug Discovery Today: Technologies 5: 95-103.
3. Pujals S, Giralt E, (2008) Proline-rich, amphipathic cell-penetrating peptides. Adv Drug Deliv Rev 60: 473-484.
4. Elmquist A, Lindgren M, Bartfai T, Langel U, (2001) VE-cadherin-derived cell-penetrating peptide, pVEC, with carrier functions. Exp Cell Res 269: 237-244.
5. Vives E, Brodin P, Lebleu B, (1997) A truncated HIV-1 Tat protein basic domain rapidly translocates through the plasma membrane and accumulates in the cell nucleus. J Biol Chem 272: 16010-16017.
6. Manish G, Vimukta S, (2011) Targeted drug delivery system: a review. Res J ChemSci 1: 135-138.
7. Wang B, Siahaan TJ, Soltero R (2005) Drug Delivery: Principles and Applications.
8. Kamada H, Okamoto T, Kawamura M, Shibata H, Abe Y, et al. (2007) Creation of novel cell-penetrating peptides for intracellular drug delivery using systematic phage display technology originated from Tat transduction domain. Biol Pharm Bull 30: 218-223.
9. Zorko M, Langel U, (2005) Cell-penetrating peptides: mechanism and kinetics of cargo delivery. Advanced Drug Delivery Reviews 57: 529-545.
10. Fawell S, Seery J, Daikh Y, Moore C, Chen LL, et al. (1994) Tat-mediated delivery of heterologous proteins into cells. Proc Natl Acad Sci U S A 91: 664-668.
11. Johnson LN, Cashman SM, Kumar-Singh R, (2008) Cell-penetrating peptide for enhanced delivery of nucleic acids and drugs to ocular tissues including retina and cornea. Mol Ther 16: 107-114.
12. Chiu YL, Ali A, Chu CY, Cao H, Rana TM, (2004) Visualizing a correlation between siRNA localization, cellular uptake, and RNAi in living cells. Chem Biol 11: 1165-1175.
13. Turner JJ, Ivanova GD, Verbeure B, Williams D, Arzumanov AA, et al. (2005) Cell-penetrating peptide conjugates of peptide nucleic acids (PNA) as inhibitors of HIV-1 Tat-dependent trans-activation in cells. Nucleic Acids Res 33: 6837-6849.
14. Rothbard JB, Garlington S, Lin Q, Kirschberg T, Kreider E, et al. (2000) Conjugation of arginine oligomers to cyclosporin A facilitates topical delivery and inhibition of inflammation. Nat Med 6: 1253-1257.
15. Yukawa H, Kagami Y, Watanabe M, Oishi K, Miyamoto Y, et al. (2010) Quantum dots labeling using octa-arginine peptides for imaging of adipose tissue-derived stem cells. Biomaterials 31: 4094-4103.
16. Lewin M, Carlesso N, Tung CH, Tang XW, Cory D, et al. (2000) Tat peptide-derivatized magnetic nanoparticles allow in vivo tracking and recovery of progenitor cells. Nat Biotechnol 18: 410-414.
17. Heitz F, Morris MC, Divita G, (2009) Twenty years of cell-penetrating peptides: from molecular mechanisms to therapeutics. Br J Pharmacol 157: 195-206.
18. Trabulo S, Cardoso A, Mano M, Pedroso de Lima M, (2010) Cell-penetrating peptides- Mechanisms of cellular uptake and generation of delivery systems. Pharmaceuticals 3: 961-993.
19. Hoyer J, Neundorf I, (2012) Peptide vectors for the nonviral delivery of nucleic acids. Acc Chem Res 45: 1048-1056.
20. Mussbach F, Franke M, Zoch A, Schaefer B, Reissmann S, (2011) Transduction of peptides and proteins into live cells by cell penetrating peptides. J Cell Biochem 112: 3824-3833.
21. Kersemans V, Cornelissen B, (2010) Targeting the tumour: Cell penetrating peptides for molecular imaging and radiotherapy. Pharmaceuticals 3: 600-620.
22. Geisler I, Chmielewski J, (2009) Cationic amphiphilic polyproline helices: side-chain variations and cell-specific internalization. Chem Biol Drug Des 73: 39-45.
23. Martin I, Teixido M, Giralt E, (2010) Building cell selectivity into CPP-mediated strategies. Pharmaceuticals 3: 1456-1490.
24. Lee HS, Park CB, Kim JM, Jang SA, Park IY, et al. (2008) Mechanism of anticancer activity of buforin IIb, a histone H2A-derived peptide. Cancer Lett 271: 47-55.
25. Cho JH, Sung BH, Kim SC, (2009) Buforins: histone H2A-derived antimicrobial peptides from toad stomach. Biochim Biophys Acta 1788: 1564-1569.
26. Lundberg M, Johansson M, (2002) Positively charged DNA-binding proteins cause apparent cell membrane translocation. Biochem Biophys Res Commun 291: 367-371.
27. Richard JP, Melikov K, Vives E, Ramos C, Verbeure B, et al. (2003) Cell-penetrating peptides. A reevaluation of the mechanism of cellular uptake. J Biol Chem 278: 585-590.
28. Aboudy Y, Mendelson E, Shalit I, Bessalle R, Fridkin M, et al. (1994) Activity of two synthetic amphiphilic peptides and magainin-2 against herpes simplex virus types 1 and 2. Int. J. Peptide Protein Res., 43: 6, 573-582.
29. Crombez L, Aldrian-Herrada G, Konate K, Nguyen QN, McMaster GK, et al. (2009) A new potent secondary amphipathic cell-penetrating peptide for siRNA delivery into mammalian cells, Molecular Therapy, 17, 95-103.
30. Bradford MM, (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254.
31. Shin SY, Lee SH, Yang ST, Park EJ, Lee DG, et al. (2001) Antibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs. J Pept Res 58: 504-514.
32. Chen Y, Mant CT, Farmer SW, Hancock RE, Vasil ML, et al. (2005) Rational design of alpha-helical antimicrobial peptides with enhanced activities and specificity/therapeutic index. J Biol Chem 280: 12316-12329.
33. Huang YB, He LY, Jiang HY, Chen YX, (2012) Role of helicity on the anticancer mechanism of action of cationic-helical peptides. Int J Mol Sci 13: 6849-6862.
34. Leuschner C, Hansel W, (2004) Membrane disrupting lytic peptides for cancer treatments. Curr Pharm Des 10: 2299-2310.
35. Papo N, Shai Y, (2003) New lytic peptides based on the D,L-amphipathic helix motif preferentially kill tumor cells compared to normal cells. Biochemistry 42: 9346-9354.
36. Cappelli G, Paladini S, D'Agata A, (1999) Tumor markers in the diagnosis of pancreatic cancer. Tumori 85: S19-21.
37. Madani F, Lindberg S, Langel U, Futaki S, Graslund A, (2011) Mechanisms of cellular uptake of cell-penetrating peptides. J Biophys 2011: 414729.
38. Doherty GJ, McMahon HT, (2009) Mechanisms of endocytosis. Annu Rev Biochem 78: 857-902.
39. Cawthorn TR, Amir E, Broom R, Freedman O, Gianfelice D, et al. (2009) Mechanisms and pathways of bone metastasis: challenges and pitfalls of performing molecular research on patient samples. Clin Exp Metastasis 26: 935-943.
40. Harvey TM, Emmanuel B, (2011) Molecular mechanism and physiological functions of clathrin-mediated endocytosis. Nature Reviews Molecular Cell biology 12: 517-533.
41. Kirsten S, Sascha P, Tore S, Bo van D, (2011) Clathrin-independent endocytosis: mechanisms and function. Current Opinion in Cell Biology 23: 413-420.
42. Tanaka T, Rabbitts TH, (2003) Intrabodies based on intracellular capture frameworks that bind the RAS protein with high affinity and impair oncogenic tramsformation. EMBO J 22: 1025-1035.
43. Deshpande AK, Kung HF, (1987) Insulin induction of Xenopus laevis oocyte maturation is inhibited by monoclonal antibody against p21 ras proteins. Mol Cell Biol 7: 1285-1288.
44. Fox PL, Sa G, Dobrowolski SF, Stacey DW, (1994) The regulation of endothelial cell motility by p21 ras. Oncogene 9: 3519-3526.
45. Cochet O, Kenigsberg M, Delumeau I, Virone-Oddos A, Multon MC, et al. (1998) Intracellular expression of an antibody fragment-neutralizing p21 ras promotes tumor regression. Cancer Res 58: 1170-1176.
46. Jeyapaul J, Reddy MR, Khan SA, (1990) Activity of synthetic tat peptides in human immunodeficiency virus type 1 long terminal repeat-promoted transcription in a cell-free system. Proc Natl Acad Sci U S A 87: 7030-7034.
47. Park CB, Yi KS, Matsuzaki K, Kim MS, Kim SC, (2000) Structure-activity analysis of buforin II, a histone H2A-derived antimicrobial peptide: the proline hinge is responsible for the cell-penetrating ability of buforin II. Proc Natl Acad Sci U S A 97: 8245-8250.