Loss of Tribbles pseudokinase-3 promotes Akt-driven tumorigenesis via FOXO inactivation

Cell Death and Differentiation

Volumn 22, Issue 1, 2015, Pages 131-144

  Salazar, M ^a,b,m   Lorente, M ^a,b,m   Garcia Taboada E ^a   Perez Gomez E ^a,c   Davila D ^a,b   Zuniga Garcia P ^d   Maria Flores J ^a   Rodriguez A ^a   Hegedus, Z ^e   Mosen Ansorena D ^d   Aransay, A M ^f   Hernandez Tiedra S ^a,b   Lopez Valero I ^a,b   Quintanilla, M ^g   Sanchez C ^a,c   Iovanna, J L ^h   Dusetti, N ^h   Guzman M ^a,i   Francis, S E ^j   Carracedo, A ^d,k,l   Kiss Toth, E ^j   Velasco, G ^a,b   more..

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^b HOSPITAL CLÍNICO SAN CARLOS   (Spain)

^c Instituto de Investigación Hospital 12 de Octubre ^*  (Spain)

^d CIC BIOGUNE   (Spain)

^e INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^f INSTITUTO DE SALUD CARLOS III   (Spain)

^g INSTITUTO DE INVESTIGACIONES BIOMÉDICAS ALBERTO SOLS   (Spain)

^h AIX MARSEILLE UNIVERSITY   (France)

ⁱ INSTITUTO RAMÓN Y CAJAL DE INVESTIGACIÓN SANITARIA IRYCIS   (Spain)

^j UNIVERSITY OF SHEFFIELD   (United Kingdom)

^k BASQUE FOUNDATION FOR SCIENCE   (Spain)

^l UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

^m Centro Nacional de Investigaciones Oncológicas   (Spain)

more..

Author keywords

[No Author keywords available]

Indexed keywords

BH3 PROTEIN; BIM PROTEIN; GLYCOGEN SYNTHASE KINASE 3; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN BCL 2; PROTEIN KINASE B INHIBITOR; PROTEIN S6; TRANSCRIPTION FACTOR FKHRL1; TRANSCRIPTION FACTOR FOXO; TRIBBLES PSEUDOKINASE 3; UNCLASSIFIED DRUG; CELL CYCLE PROTEIN; FORKHEAD TRANSCRIPTION FACTOR; FOXO3 PROTEIN, HUMAN; FOXO3 PROTEIN, MOUSE; MULTIPROTEIN COMPLEX; PROTEIN KINASE B; PROTEIN SERINE THREONINE KINASE; REPRESSOR PROTEIN; TARGET OF RAPAMYCIN KINASE; TOR COMPLEX 2; TRB3 PROTEIN, MOUSE; TRIB3 PROTEIN, HUMAN; TUMOR SUPPRESSOR PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CARCINOMA; CANCER GROWTH; CARCINOGENESIS; CELL DEATH; CELL DIFFERENTIATION; CELL FUNCTION; CELL PROLIFERATION; CLONOGENESIS; CONTROLLED STUDY; ENZYME INHIBITION; GENE DELETION; GENE EXPRESSION; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; MALIGNANT TRANSFORMATION; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; TUMOR XENOGRAFT; UPREGULATION; ANIMAL; ANTAGONISTS AND INHIBITORS; GENETICS; KNOCKOUT MOUSE; METABOLISM; NEOPLASM; NUDE MOUSE; PATHOLOGY; PHOSPHORYLATION; TUMOR CELL LINE;

ANIMALS; CELL CYCLE PROTEINS; CELL LINE, TUMOR; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; MICE; MICE, KNOCKOUT; MICE, NUDE; MULTIPROTEIN COMPLEXES; NEOPLASMS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; REPRESSOR PROTEINS; TOR SERINE-THREONINE KINASES; TUMOR SUPPRESSOR PROTEINS;

EID: 84926628915     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2014.133     Document Type: Article

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