Wnk1 kinase deficiency lowers blood pressure in mice: A gene-trap screen to identify potential targets for therapeutic intervention

Proceedings of the National Academy of Sciences of the United States of America

Volumn 100, Issue SUPPL. 2, 2003, Pages 14109-14114

  Zambrowicz, Brian P ^a   Abuin, Alejandro ^a   Ramirez Solis, Ramiro ^a   Richter, Lizabeth J ^a   Piggott, James ^a   BeltrandelRio, Hector ^a   Buxton, Eric C ^a   Edwards, Joel ^a   Finch, Rick A ^a   Friddle, Carl J ^a   Gupta, Anupma ^a   Hansen, Gwenn ^a   Hu, Yi ^a   Huang, Wenhu ^a   Jaing, Crystal ^a   Key Jr , Billie Wayne ^a   Kipp, Peter ^a   Kohlhauff, Buckley ^a   Ma, Zhi Qing ^a   Markesich, Diane ^a   Payne, Robert ^a   Potter, David G ^a   Qian, Ny ^a   Shaw, Joseph ^a   Schrick, Jeff ^a   Shi, Zheng Zheng ^a   Sparks, Mary Jean ^a   Van Sligtenhorst, Isaac ^a   Vogel, Peter ^a   Walke, Wade ^a   Xu, Nianhua ^a   Zhu, Qichao ^a   Person, Christophe ^a   Sands, Arthur T ^a   more..

^a LEXICON PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; PHOSPHOTRANSFERASE; PROTEIN KINASE WNK1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD PRESSURE REGULATION; CONTROLLED STUDY; CORRELATION ANALYSIS; EMBRYO CELL; ENZYME DEFICIENCY; GENE CONTROL; GENE DELETION; GENE FUNCTION; GENE IDENTIFICATION; GENE MUTATION; GENE TARGETING; HETEROZYGOSITY; HOMOZYGOSITY; MOLECULAR CLONING; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN FUNCTION; SEQUENCE ANALYSIS; STEM CELL TRANSPLANTATION;

ANIMALS; BASE SEQUENCE; BLOOD PRESSURE; DNA, COMPLEMENTARY; GENE LIBRARY; GENETIC TECHNIQUES; HETEROZYGOTE; HUMANS; HYPERTENSION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; MUTAGENESIS, INSERTIONAL; PHENOTYPE; PROTEIN-SERINE-THREONINE KINASES; SEQUENCE TAGGED SITES;

ANIMALIA; MAMMALIA;

EID: 10744226663     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.2336103100     Document Type: Article

References (31)

1. Waterston, R. H., Lindblad-Toh, K., Birney, E., Rogers, J., Abril, J. F., Agarwal, P., Agarwala, R., Ainscough, R., Alexandersson, M., An, P., et al. (2002) Nature 420, 520-562.
2. Lander, E. S., Linton, L. M., Birren, B., Nusbaum, C., Zody, M. C., Baldwin, J., Devon, K., Dewar, K., Doyle, M., FitzHugh, W., et al. (2001) Nature 409, 860-921.
3. Adams, M. D. & Sekelsky, J. J. (2002) Nat. Rev. Genet. 3, 189-198.
4. Jorgensen, E. M. & Mango, S. E. (2002) Nat. Rev. Genet. 3, 356-369.
5. Golling, G., Amsterdam, A., Sun, Z., Antonelli, M., Maldonado, E., Chen, W., Burgess, S., Haldi, M., Artzt, K., Farrington, S., et al. (2002) Nat. Genet. 31, 135-140.
6. Sessions, A., Burke, E., Presting, G., Aux, G., McElver, J., Patton, D., Dietrich, B., Ho, P., Bacwaden, J., Ko, C., et al. (2002) Plant Cell 14, 2985-2994.
7. Bradley, A. (2002) Nature 420, 512-514.
8. Sands, A. T. (2003) Nat. Biotechnol. 21, 31-32.
9. Zambrowicz, B. P. & Sands, A. T. (2003) Nat. Rev. Drug Discov. 2, 37-50.
10. Capecchi, M. R. (1989) Science 244, 1288-1292.
11. Friedrich, G. & Soriano, P. (1991) Genes Dev. 5, 1513-1523.
12. Skarnes, W. C., Auerbach, B. A. & Joyner, A. L. (1992) Genes Dev. 6, 903-918.
13. Zambrowicz, B. P. & Friedrich, G. A. (1998) Int. J. Dev. Biol. 42, 1025-1036.
14. Balling, R. (2001) Annu. Rev. Genomics Hum. Genet. 2, 463-492.
15. Zambrowicz, B. P., Friedrich, G. A., Buxton, E. C., Lilleberg, S. L., Person, C. & Sands, A. T. (1998) Nature 392, 608-611.
16. Xu, B., English, J. M., Wilsbacher, J. L., Stippec, S., Goldsmith, E. J. & Cobb, M. H. (2000) J. Biol. Chem. 275, 16795-16801.
17. Xu, B. E., Min, X., Stippec, S., Lee, B. H., Goldsmith, E. J. & Cobb, M. H. (2002) J. Biol. Chem. 277, 48456-48462.
18. Choate, K. A., Kahle, K. T., Wilson, F. H., Nelson-Williams, C. & Lifton, R. P. (2003) Proc. Natl. Acad. Sci. USA 100, 663-668.
19. Wilson, F. H., Disse-Nicodeme, S., Choate, K. A., Ishikawa, K., Nelson-Williams, C., Desitter, I., Gunel, M., Milford, D. V., Lipkin, G. W., Achard, J. M., et al. (2001) Science 293, 1107-1112.
20. Joyner, A. L. (2000) Gene Targeting: A Practical Approach (Oxford Univ. Press, Oxford).
21. Karlin, S. & Altschul, S. F. (1990) Proc. Natl. Acad. Sci. USA 87, 2264-2268.
22. Altschul, S., Madden, T., Schaffer, A., Zhang, J., Zhang, Z., Miller, W. & Lipman, D. (1997) Nucleic Acids Res. 25, 3389-3402.
23. Silver, J. & Keerikatte, V. (1989) J. Virol. 63, 1924-1928.
24. BeltrandelRio, H., Kern, F., Lanthorn, T., Oravecz, T., Piggott, J., Powell, D., Ramirez-Solis, R., Sands, A. T. & Zambrowicz, B. in Model Organisms in Drug Discovery, ed. Carroll, P. (Wiley & Sons, Chichester, U.K.), in press.
25. Lian, Z., Kluger, Y., Greenbaum, D. S., Tuck, D., Gerstein, M., Berliner, N., Weissman, S. M. & Newburger, P. E. (2002) Blood 100, 3209-3220.
26. Kern, W., Kohlmann, A., Wuchter, C., Schnittger, S., Schoch, C., Mergenthaler, S., Ratei, R., Ludwig, W. D., Hiddemann, W. & Haferlach, T. (2003) Cytometry 55B, 29-36.
27. Yang, C.-L., Angell, J., Mitchell, R. & Ellison, D. H. (2003) J. Clin. Invest. 111, 1039-1045.
28. Ito, M., Oliverio, M. I., Mannon, P. J., Best, C. F., Maeda, N., Smithies, O. & Coffman, T. M. (1995) Proc. Natl. Acad. Sci. USA 92, 3521-3525.
29. Sugaya, T., Nishimatsu, S., Tanimoto, K., Takimoto, E., Yamagishi, T., Imamura, K., Goto, S., Imaizumi, K., Hisada, Y., Otsuka, A., et al. (1995) J. Biol. Chem. 270, 18719-18722.
30. Oliverio, M. I. & Coffman, T. M. (1997) Clin. Cardiol. 20, 3-6.
31. Krege, J. H., John, S. W., Langenbach, L. L., Hodgin, J. B., Hagaman, J. R., Bachman, E. S., Jennette, J. C., O'Brien, D. A. & Smithies, O. (1995) Nature 375, 146-148.