메뉴 건너뛰기




Volumn 2015, Issue , 2015, Pages

Comprehensive review on betulin as a potent anticancer agent

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BETULIN; CASPASE 3; CASPASE 7; CASPASE 9; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN BCL 2; TRITERPENE;

EID: 84926512810     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2015/584189     Document Type: Article
Times cited : (173)

References (81)
  • 4
    • 0037012040 scopus 로고    scopus 로고
    • Mitochondrial dysfunction is an essential step for killing of non-small cell lung carcinomas resistant to conventional treatment
    • B. Joseph, P. Marchetti, P. Formstecher, G. Kroemer, R. Lewensohn, and B. Zhivotovsky, "Mitochondrial dysfunction is an essential step for killing of non-small cell lung carcinomas resistant to conventional treatment," Oncogene, Vol. 21, no. 1, pp. 65-77, 2002.
    • (2002) Oncogene , vol.21 , Issue.1 , pp. 65-77
    • Joseph, B.1    Marchetti, P.2    Formstecher, P.3    Kroemer, G.4    Lewensohn, R.5    Zhivotovsky, B.6
  • 5
    • 0034082239 scopus 로고    scopus 로고
    • The influence of natural products upon drug discovery
    • D. J. Newman, G. M. Cragg, and K. M. Snader, "The influence of natural products upon drug discovery," Natural Product Reports, Vol. 17, no. 3, pp. 215-234, 2000.
    • (2000) Natural Product Reports , vol.17 , Issue.3 , pp. 215-234
    • Newman, D.J.1    Cragg, G.M.2    Snader, K.M.3
  • 6
    • 34447096207 scopus 로고    scopus 로고
    • Plant natural products: Back to the future or into extinction?
    • J. D. McChesney, S. K. Venkataraman, and J. T. Henri, "Plant natural products: Back to the future or into extinction?" Phytochemistry, Vol. 68, no. 14, pp. 2015-2022, 2007.
    • (2007) Phytochemistry , vol.68 , Issue.14 , pp. 2015-2022
    • McChesney, J.D.1    Venkataraman, S.K.2    Henri, J.T.3
  • 7
    • 34247109045 scopus 로고    scopus 로고
    • Natural products as sources of new drugs over the last 25 years
    • D. J. Newman and G. M. Cragg, "Natural products as sources of new drugs over the last 25 years," Journal of Natural Products, Vol. 70, no. 3, pp. 461-477, 2007.
    • (2007) Journal of Natural Products , vol.70 , Issue.3 , pp. 461-477
    • Newman, D.J.1    Cragg, G.M.2
  • 8
    • 1442334562 scopus 로고    scopus 로고
    • Camptothecin and taxol: Historic achievements in natural products research
    • N. H. Oberlies and D. J. Kroll, "Camptothecin and taxol: historic achievements in natural products research," Journal of Natural Products, Vol. 67, no. 2, pp. 129-135, 2004.
    • (2004) Journal of Natural Products , vol.67 , Issue.2 , pp. 129-135
    • Oberlies, N.H.1    Kroll, D.J.2
  • 10
    • 27744577599 scopus 로고    scopus 로고
    • Biogenesis, molecular regulation and function of plant isoprenoids
    • F. Bouvier, A. Rahier, and B. Camara, "Biogenesis, molecular regulation and function of plant isoprenoids," Progress in Lipid Research, Vol. 44, no. 6, pp. 357-429, 2005.
    • (2005) Progress in Lipid Research , vol.44 , Issue.6 , pp. 357-429
    • Bouvier, F.1    Rahier, A.2    Camara, B.3
  • 12
    • 74049157757 scopus 로고    scopus 로고
    • Pentacyclic triterpenes of the lupane, oleanane and ursane group as tools in cancer therapy
    • M. N. Laszczyk, "Pentacyclic triterpenes of the lupane, oleanane and ursane group as tools in cancer therapy," Planta Medica, Vol. 75, no. 15, pp. 1549-1560, 2009.
    • (2009) Planta Medica , vol.75 , Issue.15 , pp. 1549-1560
    • Laszczyk, M.N.1
  • 13
    • 67651100837 scopus 로고    scopus 로고
    • Esters of betulin and betulinic acid with amino acids have improved water solubility and are selectively cytotoxic toward cancer cells
    • M. Drag-Zalesinska, J. Kulbacka, J. Saczko et al., "Esters of betulin and betulinic acid with amino acids have improved water solubility and are selectively cytotoxic toward cancer cells," Bioorganic and Medicinal Chemistry Letters, Vol. 19, no. 16, pp. 4814-4817, 2009.
    • (2009) Bioorganic and Medicinal Chemistry Letters , vol.19 , Issue.16 , pp. 4814-4817
    • Drag-Zalesinska, M.1    Kulbacka, J.2    Saczko, J.3
  • 14
    • 84863823475 scopus 로고    scopus 로고
    • Biologically active pentacyclic triterpenes and their current medicine signification
    • J. Patočka, "Biologically active pentacyclic triterpenes and their current medicine signification," Journal of Applied Biomedicine, Vol. 10, no. 3, pp. 7-12, 2012.
    • (2012) Journal of Applied Biomedicine , vol.10 , Issue.3 , pp. 7-12
    • Patočka, J.1
  • 15
    • 0001115764 scopus 로고
    • The submarin monomers and triterpenoids from the outer bark of betula verrucosa EHRH
    • R. Ekman, "The submarin monomers and triterpenoids from the outer bark of betula verrucosa EHRH," Holzforschung, Vol. 37, no. 4, pp. 205-211, 1983.
    • (1983) Holzforschung , vol.37 , Issue.4 , pp. 205-211
    • Ekman, R.1
  • 16
    • 84862234891 scopus 로고    scopus 로고
    • Physico-chemical comparison of betulinic acid, betulin and birch bark extract and in vitro investigation of their cytotoxic effects towards skin epidermoid carcinoma (A431), breast carcinoma (MCF7) and cervix adenocarcinoma (HeLa) cell lines
    • C. M. Şoica, C. A. Dehelean, C. Peev et al., "Physico-chemical comparison of betulinic acid, betulin and birch bark extract and in vitro investigation of their cytotoxic effects towards skin epidermoid carcinoma (A431), breast carcinoma (MCF7) and cervix adenocarcinoma (HeLa) cell lines," Natural Product Research, Vol. 26, no. 10, pp. 968-974, 2012.
    • (2012) Natural Product Research , vol.26 , Issue.10 , pp. 968-974
    • Şoica, C.M.1    Dehelean, C.A.2    Peev, C.3
  • 17
    • 67651097886 scopus 로고    scopus 로고
    • The effect of extraction process on polyphenol content, triterpene composition and bioactivity of yellow birch (Betula alleghaniensis Britton) extracts
    • P. N. Diouf, T. Stevanovic, and Y. Boutin, "The effect of extraction process on polyphenol content, triterpene composition and bioactivity of yellow birch (Betula alleghaniensis Britton) extracts," Industrial Crops and Products, Vol. 30, no. 2, pp. 297-303, 2009.
    • (2009) Industrial Crops and Products , vol.30 , Issue.2 , pp. 297-303
    • Diouf, P.N.1    Stevanovic, T.2    Boutin, Y.3
  • 18
    • 2942631573 scopus 로고    scopus 로고
    • Antitumor-promoting constituents from Chaenomeles sinensis KOEHNE and their activities in JB6 mouse epidermal cells
    • H. Gao, L. Wu, M. Kuroyanagi et al., "Antitumor-promoting constituents from Chaenomeles sinensis KOEHNE and their activities in JB6 mouse epidermal cells," Chemical and Pharmaceutical Bulletin, Vol. 51, no. 11, pp. 1318-1321, 2003.
    • (2003) Chemical and Pharmaceutical Bulletin , vol.51 , Issue.11 , pp. 1318-1321
    • Gao, H.1    Wu, L.2    Kuroyanagi, M.3
  • 19
    • 0038457334 scopus 로고    scopus 로고
    • Cytotoxic triterpenes from the twigs of Celtis philippinensis
    • B. Y. Hwang, H.-B. Chai, L. B. S. Kardono et al., "Cytotoxic triterpenes from the twigs of Celtis philippinensis," Phytochemistry, Vol. 62, no. 2, pp. 197-201, 2003.
    • (2003) Phytochemistry , vol.62 , Issue.2 , pp. 197-201
    • Hwang, B.Y.1    Chai, H.-B.2    Kardono, L.B.S.3
  • 20
    • 84861494441 scopus 로고    scopus 로고
    • Chemical constituents of the ethyl acetate extract of belamcanda chinensis (L.) DC roots and their antitumor activities
    • M. Liu, S. Yeng, L. Jin, D. Hu, Z. Wu, and S. Yang, "Chemical constituents of the ethyl acetate extract of belamcanda chinensis (L.) DC roots and their antitumor activities," Molecules, Vol. 17, no. 5, pp. 6156-6169, 2012.
    • (2012) Molecules , vol.17 , Issue.5 , pp. 6156-6169
    • Liu, M.1    Yeng, S.2    Jin, L.3    Hu, D.4    Wu, Z.5    Yang, S.6
  • 22
    • 84873152925 scopus 로고    scopus 로고
    • Discovery and antitumor activities of constituents from Cyrtomium fortumei (J.) Smith rhizomes
    • S. Yang, M. Liu, N. Liang, Q. Zhao, Y. Zhang, and W. Xue, "Discovery and antitumor activities of constituents from Cyrtomium fortumei (J.) Smith rhizomes," Chemistry Central Journal, Vol. 7, no. 1, article 24, 2013.
    • (2013) Chemistry Central Journal , vol.7 , Issue.1
    • Yang, S.1    Liu, M.2    Liang, N.3    Zhao, Q.4    Zhang, Y.5    Xue, W.6
  • 23
    • 70449674494 scopus 로고    scopus 로고
    • Betulin elicits anticancer effects in tumour primary cultures and cell lines in vitro
    • W. Rzeski, A. Stepulak, M. Szymański et al., "Betulin elicits anticancer effects in tumour primary cultures and cell lines in vitro," Basic and Clinical Pharmacology and Toxicology, Vol. 105, no. 6, pp. 425-432, 2009.
    • (2009) Basic and Clinical Pharmacology and Toxicology , vol.105 , Issue.6 , pp. 425-432
    • Rzeski, W.1    Stepulak, A.2    Szymański, M.3
  • 24
    • 84861118462 scopus 로고    scopus 로고
    • Betulin induces apoptosis of HeLa cell lines in vitro and its possible mechanism
    • D.-Y. Wang, J. Liu, M.-Z. Yin et al., "Betulin induces apoptosis of HeLa cell lines in vitro and its possible mechanism," Tumor, Vol. 32, no. 4, pp. 234-238, 2012.
    • (2012) Tumor , vol.32 , Issue.4 , pp. 234-238
    • Wang, D.-Y.1    Liu, J.2    Yin, M.-Z.3
  • 25
    • 0037420880 scopus 로고    scopus 로고
    • Antileukemia activities of Lup-28-al-20(29)-en-3-one, a lupane triterpene
    • K. Hata, K. Hori, H. Ogasawara, and S. Takahashi, "Antileukemia activities of Lup-28-al-20(29)-en-3-one, a lupane triterpene," Toxicology Letters, Vol. 143, no. 1, pp. 1-7, 2003.
    • (2003) Toxicology Letters , vol.143 , Issue.1 , pp. 1-7
    • Hata, K.1    Hori, K.2    Ogasawara, H.3    Takahashi, S.4
  • 26
    • 77954488236 scopus 로고    scopus 로고
    • Betulin induces mitochondrial cytochrome c release associated apoptosis in human cancer cells
    • Y. Li, K. He, Y. Huang et al., "Betulin induces mitochondrial cytochrome c release associated apoptosis in human cancer cells," Molecular Carcinogenesis, Vol. 49, no. 7, pp. 630-640, 2010.
    • (2010) Molecular Carcinogenesis , vol.49 , Issue.7 , pp. 630-640
    • Li, Y.1    He, K.2    Huang, Y.3
  • 27
    • 33747203295 scopus 로고    scopus 로고
    • Glycosidation of lupane-type triterpenoids as potent in vitro cytotoxic agents
    • C. Gauthier, J. Legault, M. Lebrun, P. Dufour, and A. Pichette, "Glycosidation of lupane-type triterpenoids as potent in vitro cytotoxic agents," Bioorganic and Medicinal Chemistry, Vol. 14, no. 19, pp. 6713-6725, 2006.
    • (2006) Bioorganic and Medicinal Chemistry , vol.14 , Issue.19 , pp. 6713-6725
    • Gauthier, C.1    Legault, J.2    Lebrun, M.3    Dufour, P.4    Pichette, A.5
  • 29
    • 63149128707 scopus 로고    scopus 로고
    • Anti-cancer effect of betulin on a human lung cancer cell line: A pharmacoproteomic approach using 2 D SDS PAGE coupled with nano-HPLC tandem mass spectrometry
    • S. P. Jae, H. R. Si, K. K. Dae et al., "Anti-cancer effect of betulin on a human lung cancer cell line: a pharmacoproteomic approach using 2 D SDS PAGE coupled with nano-HPLC tandem mass spectrometry," Planta Medica, Vol. 75, no. 2, pp. 127-131, 2009.
    • (2009) Planta Medica , vol.75 , Issue.2 , pp. 127-131
    • Jae, S.P.1    Si, H.R.2    Dae, K.K.3
  • 30
    • 84866306164 scopus 로고    scopus 로고
    • Antioxidant properties and cytotoxic effects on human cancer cell lines of aqueous fermented and lipophilic quince (Cydonia oblonga Mill.) preparations
    • S. Pacifico, M. Gallicchio, A. Fiorentino, A. Fischer, U. Meyer, and F. C. Stintzing, "Antioxidant properties and cytotoxic effects on human cancer cell lines of aqueous fermented and lipophilic quince (Cydonia oblonga Mill.) preparations," Food and Chemical Toxicology, Vol. 50, no. 11, pp. 4130-4135, 2012.
    • (2012) Food and Chemical Toxicology , vol.50 , Issue.11 , pp. 4130-4135
    • Pacifico, S.1    Gallicchio, M.2    Fiorentino, A.3    Fischer, A.4    Meyer, U.5    Stintzing, F.C.6
  • 32
    • 84865285704 scopus 로고    scopus 로고
    • Betulin as an antitumor agent tested in vitro on A431, HeLa and MCF7, and as an angiogenic inhibitor in vivo in the CAM assay
    • C. A. Dehelean, S. Feflea, J. Molnár, I. Zupko, and C. Soica, "Betulin as an antitumor agent tested in vitro on A431, HeLa and MCF7, and as an angiogenic inhibitor in vivo in the CAM assay," Natural Product Communications, Vol. 7, no. 8, pp. 981-985, 2012.
    • (2012) Natural Product Communications , vol.7 , Issue.8 , pp. 981-985
    • Dehelean, C.A.1    Feflea, S.2    Molnár, J.3    Zupko, I.4    Soica, C.5
  • 33
    • 84876764238 scopus 로고    scopus 로고
    • Synthesis, structure and cytotoxic activity of new acetylenic derivatives of betulin
    • S. Boryczka, E. Bebenek, J. Wietrzyk et al., "Synthesis, structure and cytotoxic activity of new acetylenic derivatives of betulin," Molecules, Vol. 18, no. 4, pp. 4526-4543, 2013.
    • (2013) Molecules , vol.18 , Issue.4 , pp. 4526-4543
    • Boryczka, S.1    Bebenek, E.2    Wietrzyk, J.3
  • 34
    • 33244472337 scopus 로고    scopus 로고
    • Antiproliferative terpenoids from almond hulls (Prunus dulcis): Identification and structure-activity relationships
    • V. Amico, V. Barresi, D. Condorelli, C. Spatafora, and C. Tringali, "Antiproliferative terpenoids from almond hulls (Prunus dulcis): identification and structure-activity relationships," Journal of Agricultural and Food Chemistry, Vol. 54, no. 3, pp. 810-814, 2006.
    • (2006) Journal of Agricultural and Food Chemistry , vol.54 , Issue.3 , pp. 810-814
    • Amico, V.1    Barresi, V.2    Condorelli, D.3    Spatafora, C.4    Tringali, C.5
  • 36
    • 66349104551 scopus 로고    scopus 로고
    • Comparision of the cytotoxic effects of birch bark extract, betulin and betulinic acid towards human gastric carcinoma and pancreatic carcinoma drug-sensitive and drugresistant cell lines
    • M. Drag, P. Surowiak, D.-Z. Malgorzata, M. Dietel, H. Lage, and J. Oleksyszyn, "Comparision of the cytotoxic effects of birch bark extract, betulin and betulinic acid towards human gastric carcinoma and pancreatic carcinoma drug-sensitive and drugresistant cell lines," Molecules, Vol. 14, no. 4, pp. 1639-1651, 2009.
    • (2009) Molecules , vol.14 , Issue.4 , pp. 1639-1651
    • Drag, M.1    Surowiak, P.2    Malgorzata, D.-Z.3    Dietel, M.4    Lage, H.5    Oleksyszyn, J.6
  • 37
    • 0036098929 scopus 로고    scopus 로고
    • Differentiation- and apoptosis-inducing activities by pentacyclic triterpenes on a mouse melanoma cell line
    • K. Hata, K. Hori, and S. Takahashi, "Differentiation- and apoptosis-inducing activities by pentacyclic triterpenes on a mouse melanoma cell line," Journal of Natural Products, Vol. 65, no. 5, pp. 645-648, 2002.
    • (2002) Journal of Natural Products , vol.65 , Issue.5 , pp. 645-648
    • Hata, K.1    Hori, K.2    Takahashi, S.3
  • 38
    • 0032493481 scopus 로고    scopus 로고
    • Synthesis of betulinic acid derivatives with activity against human melanoma
    • D. S. H. L. Kim, J. M. Pezzuto, and E. Pisha, "Synthesis of betulinic acid derivatives with activity against human melanoma," Bioorganic & Medicinal Chemistry Letters, Vol. 8, no. 13, pp. 1707-1712, 1998.
    • (1998) Bioorganic & Medicinal Chemistry Letters , vol.8 , Issue.13 , pp. 1707-1712
    • Kim, D.S.H.L.1    Pezzuto, J.M.2    Pisha, E.3
  • 39
    • 84870677944 scopus 로고    scopus 로고
    • Betulin complex in γ-cyclodextrin derivatives: Properties and antineoplasic activities in in vitro and in vivo tumor models
    • C. Şoica, C. Dehelean, C. Danciu et al., "Betulin complex in γ-cyclodextrin derivatives: properties and antineoplasic activities in in vitro and in vivo tumor models," International Journal of Molecular Sciences, Vol. 13, no. 11, pp. 14992-15011, 2012.
    • (2012) International Journal of Molecular Sciences , vol.13 , Issue.11 , pp. 14992-15011
    • Şoica, C.1    Dehelean, C.2    Danciu, C.3
  • 41
    • 84861196055 scopus 로고    scopus 로고
    • Cytotoxic heterocyclic triterpenoids derived from betulin and betulinic acid
    • M. Urban, M. Vlk, P. Dzubak, M. Hajduch, and J. Sarek, "Cytotoxic heterocyclic triterpenoids derived from betulin and betulinic acid," Bioorganic and Medicinal Chemistry, Vol. 20, no. 11, pp. 3666-3674, 2012.
    • (2012) Bioorganic and Medicinal Chemistry , vol.20 , Issue.11 , pp. 3666-3674
    • Urban, M.1    Vlk, M.2    Dzubak, P.3    Hajduch, M.4    Sarek, J.5
  • 42
    • 58149240781 scopus 로고    scopus 로고
    • A preliminary pharmacokinetic study of betulin, the main pentacyclic triterpene from extract of outer bark of birch (Betulae alba cortex)
    • S. Jäger, M. N. Laszczyk, and A. Scheffler, "A preliminary pharmacokinetic study of betulin, the main pentacyclic triterpene from extract of outer bark of birch (Betulae alba cortex)," Molecules, Vol. 13, no. 12, pp. 3224-3235, 2008.
    • (2008) Molecules , vol.13 , Issue.12 , pp. 3224-3235
    • Jäger, S.1    Laszczyk, M.N.2    Scheffler, A.3
  • 43
    • 84869116273 scopus 로고    scopus 로고
    • Study of the betulin enriched birch bark extracts effects on human carcinoma cells and ear inflammation
    • C. A. Dehelean, C. Şoica, I. Ledeţi et al., "Study of the betulin enriched birch bark extracts effects on human carcinoma cells and ear inflammation," Chemistry Central Journal, Vol. 6, no. 1, article 137, 2012.
    • (2012) Chemistry Central Journal , vol.6 , Issue.1
    • Dehelean, C.A.1    Şoica, C.2    Ledeţi, I.3
  • 44
    • 33846194218 scopus 로고    scopus 로고
    • Physical, chemical and pharmacological characterization of a new oleogel-forming triterpene extract from the outer bark of birch (Betulae cortex)
    • M. Laszczyk, S. Jäger, B. Simon-Haarhaus, A. Scheffler, and C. M. Schempp, "Physical, chemical and pharmacological characterization of a new oleogel-forming triterpene extract from the outer bark of birch (Betulae cortex)," Planta Medica, Vol. 72, no. 15, pp. 1389-1395, 2006.
    • (2006) Planta Medica , vol.72 , Issue.15 , pp. 1389-1395
    • Laszczyk, M.1    Jäger, S.2    Simon-Haarhaus, B.3    Scheffler, A.4    Schempp, C.M.5
  • 45
    • 33751330871 scopus 로고    scopus 로고
    • Birch bark research and development
    • P. A. Krasutsky, "Birch bark research and development," Natural Product Reports, Vol. 23, no. 6, pp. 919-942, 2006.
    • (2006) Natural Product Reports , vol.23 , Issue.6 , pp. 919-942
    • Krasutsky, P.A.1
  • 46
    • 84876543679 scopus 로고    scopus 로고
    • Antiangiogenic and anti-cancer evaluation of betulin nanoemulsion in chicken chorioallantoic membrane and skin carcinoma in Balb/c mice
    • C. A. Dehelean, S. Feflea, D. Gheorgheosu et al., "Antiangiogenic and anti-cancer evaluation of betulin nanoemulsion in chicken chorioallantoic membrane and skin carcinoma in Balb/c mice," Journal of Biomedical Nanotechnology, Vol. 9, no. 4, pp. 577-589, 2013.
    • (2013) Journal of Biomedical Nanotechnology , vol.9 , Issue.4 , pp. 577-589
    • Dehelean, C.A.1    Feflea, S.2    Gheorgheosu, D.3
  • 47
    • 14644407525 scopus 로고    scopus 로고
    • The role of apoptosis in cancer development and treatment response
    • M. Brown and L. D. Attardi, "The role of apoptosis in cancer development and treatment response," Nature Reviews Cancer, Vol. 5, no. 3, pp. 231-237, 2005.
    • (2005) Nature Reviews Cancer , vol.5 , Issue.3 , pp. 231-237
    • Brown, M.1    Attardi, L.D.2
  • 48
    • 33746886979 scopus 로고    scopus 로고
    • Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy
    • S. Fulda and K. M. Debatin, "Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy," Oncogene, Vol. 25, no. 34, pp. 4798-4811, 2006.
    • (2006) Oncogene , vol.25 , Issue.34 , pp. 4798-4811
    • Fulda, S.1    Debatin, K.M.2
  • 49
    • 34250308322 scopus 로고    scopus 로고
    • Apoptosis: A review of programmed cell death
    • S. Elmore, "Apoptosis: a review of programmed cell death," Toxicologic Pathology, Vol. 35, no. 4, pp. 495-516, 2007.
    • (2007) Toxicologic Pathology , vol.35 , Issue.4 , pp. 495-516
    • Elmore, S.1
  • 50
    • 43449108570 scopus 로고    scopus 로고
    • Deregulation of the mitochondrial apoptotic machinery and development of molecular targeted drugs in acute myeloid leukemia
    • G. Del Poeta, A. Bruno, M. I. Del Principe et al., "Deregulation of the mitochondrial apoptotic machinery and development of molecular targeted drugs in acute myeloid leukemia," Current Cancer Drug Targets, Vol. 8, no. 3, pp. 207-222, 2008.
    • (2008) Current Cancer Drug Targets , vol.8 , Issue.3 , pp. 207-222
    • Del Poeta, G.1    Bruno, A.2    Del Principe, M.I.3
  • 51
    • 46949083766 scopus 로고    scopus 로고
    • Dysregulation of apoptotic signaling in cancer: Molecular mechanisms and therapeutic opportunities
    • J. Plati, O. Bucur, and R. Khosravi-Far, "Dysregulation of apoptotic signaling in cancer: molecular mechanisms and therapeutic opportunities," Journal of Cellular Biochemistry, Vol. 104, no. 4, pp. 1124-1149, 2008.
    • (2008) Journal of Cellular Biochemistry , vol.104 , Issue.4 , pp. 1124-1149
    • Plati, J.1    Bucur, O.2    Khosravi-Far, R.3
  • 52
    • 79951977936 scopus 로고    scopus 로고
    • Regulation of death receptor-induced apoptosis induced via CD95/FAS and other death receptors
    • I. N. Lavrik, "Regulation of death receptor-induced apoptosis induced via CD95/FAS and other death receptors," Molekuliarnaia Biologiia, Vol. 45, no. 1, pp. 173-179, 2011.
    • (2011) Molekuliarnaia Biologiia , vol.45 , Issue.1 , pp. 173-179
    • Lavrik, I.N.1
  • 54
    • 65449179903 scopus 로고    scopus 로고
    • Betulin is a potent anti-tumor agent that is enhanced-by cholesterol
    • Article ID e5361
    • F. B. Mullauer, J. H. Kessler, and J. P. Medema, "Betulin is a potent anti-tumor agent that is enhanced-by cholesterol," PLoS ONE, Vol. 4, no. 4, article e1, Article ID e5361, 2009.
    • (2009) PLoS ONE , vol.4 , Issue.4
    • Mullauer, F.B.1    Kessler, J.H.2    Medema, J.P.3
  • 55
    • 0034660892 scopus 로고    scopus 로고
    • The pezcoller lecture: Cancer cell cycles revisited
    • C. J. Sherr, "The pezcoller lecture: cancer cell cycles revisited," Cancer Research, Vol. 60, no. 14, pp. 3689-3695, 2000.
    • (2000) Cancer Research , vol.60 , Issue.14 , pp. 3689-3695
    • Sherr, C.J.1
  • 56
    • 33644830944 scopus 로고    scopus 로고
    • Targeting the cell cycle: A new approach to cancer therapy
    • G. K. Schwartz and M. A. Shah, "Targeting the cell cycle: a new approach to cancer therapy," Journal of Clinical Oncology, Vol. 23, no. 36, pp. 9408-9421, 2005.
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.36 , pp. 9408-9421
    • Schwartz, G.K.1    Shah, M.A.2
  • 57
    • 0036765673 scopus 로고    scopus 로고
    • Antitumor activity of palmitic acid found as a selective cytotoxic substance in a marine red alga
    • H. Harada, U. Yamashita, H. Kurihara, E. Fukushi, J. Kawabata, and Y. Kamei, "Antitumor activity of palmitic acid found as a selective cytotoxic substance in a marine red alga," Anticancer Research, Vol. 22, no. 5, pp. 2587-2590, 2002.
    • (2002) Anticancer Research , vol.22 , Issue.5 , pp. 2587-2590
    • Harada, H.1    Yamashita, U.2    Kurihara, H.3    Fukushi, E.4    Kawabata, J.5    Kamei, Y.6
  • 58
    • 3142655814 scopus 로고    scopus 로고
    • Acetone extract of Angelica sinensis inhibits proliferation of human cancer cells via inducing cell cycle arrest and apoptosis
    • Y.-L. Cheng, W.-L. Chang, S.-C. Lee et al., "Acetone extract of Angelica sinensis inhibits proliferation of human cancer cells via inducing cell cycle arrest and apoptosis," Life Sciences, Vol. 75, no. 13, pp. 1579-1594, 2004.
    • (2004) Life Sciences , vol.75 , Issue.13 , pp. 1579-1594
    • Cheng, Y.-L.1    Chang, W.-L.2    Lee, S.-C.3
  • 59
    • 33845973448 scopus 로고    scopus 로고
    • Cranberry phytochemical extracts induce cell cycle arrest and apoptosis in human MCF-7 breast cancer cells
    • J. Sun and R. Hai Liu, "Cranberry phytochemical extracts induce cell cycle arrest and apoptosis in human MCF-7 breast cancer cells," Cancer Letters, Vol. 241, no. 1, pp. 124-134, 2006.
    • (2006) Cancer Letters , vol.241 , Issue.1 , pp. 124-134
    • Sun, J.1    Hai Liu, R.2
  • 60
    • 77954756984 scopus 로고    scopus 로고
    • Salidroside induces cell-cycle arrest and apoptosis in human breast cancer cells
    • X. Hu, X. Zhang, S. Qiu, D. Yu, and S. Lin, "Salidroside induces cell-cycle arrest and apoptosis in human breast cancer cells," Biochemical and Biophysical Research Communications, Vol. 398, no. 1, pp. 62-67, 2010.
    • (2010) Biochemical and Biophysical Research Communications , vol.398 , Issue.1 , pp. 62-67
    • Hu, X.1    Zhang, X.2    Qiu, S.3    Yu, D.4    Lin, S.5
  • 61
    • 32044458623 scopus 로고    scopus 로고
    • Protection of betulin against cadmium-induced apoptosis in hepatoma cells
    • S. H. Oh, J. E. Choi, and S. C. Lim, "Protection of betulin against cadmium-induced apoptosis in hepatoma cells," Toxicology, Vol. 220, no. 1, pp. 1-12, 2006.
    • (2006) Toxicology , vol.220 , Issue.1 , pp. 1-12
    • Oh, S.H.1    Choi, J.E.2    Lim, S.C.3
  • 62
    • 0035684524 scopus 로고    scopus 로고
    • Screening of triterpenoids isolated from Phyllanthus flexuosus for DNA topoisomerase inhibitory activity
    • S.-I. Wada, A. Iida, and R. Tanaka, "Screening of triterpenoids isolated from Phyllanthus flexuosus for DNA topoisomerase inhibitory activity," Journal of Natural Products, Vol. 64, no. 12, pp. 1545-1547, 2001.
    • (2001) Journal of Natural Products , vol.64 , Issue.12 , pp. 1545-1547
    • Wada, S.-I.1    Iida, A.2    Tanaka, R.3
  • 63
    • 0032500543 scopus 로고    scopus 로고
    • Requirement of caspase-3(-like) protease-mediated hydrogen peroxide production for apoptosis induced by various anticancer drugs
    • S. Simizu, M. Takada, K. Umezawa, and M. Imoto, "Requirement of caspase-3(-like) protease-mediated hydrogen peroxide production for apoptosis induced by various anticancer drugs," The Journal of Biological Chemistry, Vol. 273, no. 41, pp. 26900-26907, 1998.
    • (1998) The Journal of Biological Chemistry , vol.273 , Issue.41 , pp. 26900-26907
    • Simizu, S.1    Takada, M.2    Umezawa, K.3    Imoto, M.4
  • 64
    • 0033583313 scopus 로고    scopus 로고
    • Caspase-dependent activation of calpain during drug-induced apoptosis
    • D. E. Wood and E. W. Newcomb, "Caspase-dependent activation of calpain during drug-induced apoptosis," The Journal of Biological Chemistry, Vol. 274, no. 12, pp. 8309-8315, 1999.
    • (1999) The Journal of Biological Chemistry , vol.274 , Issue.12 , pp. 8309-8315
    • Wood, D.E.1    Newcomb, E.W.2
  • 65
    • 0030062263 scopus 로고    scopus 로고
    • Selective inhibition of cyclic AMP-dependent protein kinase by amphiphilic triterpenoids and related compounds
    • B. H. Wang and G. M. Polya, "Selective inhibition of cyclic AMP-dependent protein kinase by amphiphilic triterpenoids and related compounds," Phytochemistry, Vol. 41, no. 1, pp. 55-63, 1996.
    • (1996) Phytochemistry , vol.41 , Issue.1 , pp. 55-63
    • Wang, B.H.1    Polya, G.M.2
  • 66
    • 39049151617 scopus 로고    scopus 로고
    • Deregulation of the akt pathway in human cancer
    • E. Tokunaga, E. Oki, A. Egashira et al., "Deregulation of the akt pathway in human cancer," Current Cancer Drug Targets, Vol. 8, no. 1, pp. 27-36, 2008.
    • (2008) Current Cancer Drug Targets , vol.8 , Issue.1 , pp. 27-36
    • Tokunaga, E.1    Oki, E.2    Egashira, A.3
  • 67
    • 34248591612 scopus 로고    scopus 로고
    • Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer
    • P. J. Roberts and C. J. Der, "Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer," Oncogene, Vol. 26, no. 22, pp. 3291-3310, 2007.
    • (2007) Oncogene , vol.26 , Issue.22 , pp. 3291-3310
    • Roberts, P.J.1    Der, C.J.2
  • 68
    • 34548810777 scopus 로고    scopus 로고
    • Betulin binds to melanocortin receptors and antagonizes α-melanocyte stimulating hormone induced cAMP generation in mouse melanoma cells
    • R. Muceniece, K. Saleniece, U. Riekstina, L. Krigere, G. Tirzitis, and J. Ancans, "Betulin binds to melanocortin receptors and antagonizes α-melanocyte stimulating hormone induced cAMP generation in mouse melanoma cells," Cell Biochemistry and Function, Vol. 25, no. 5, pp. 591-596, 2007.
    • (2007) Cell Biochemistry and Function , vol.25 , Issue.5 , pp. 591-596
    • Muceniece, R.1    Saleniece, K.2    Riekstina, U.3    Krigere, L.4    Tirzitis, G.5    Ancans, J.6
  • 69
    • 0030063467 scopus 로고    scopus 로고
    • Immunological localisation of melanocortin 1 receptor on the cell surface of WM266-4 human melanoma cells
    • Y. Xia, R. Muceniece, and J. E. S. Wikberg, "Immunological localisation of melanocortin 1 receptor on the cell surface of WM266-4 human melanoma cells," Cancer Letters, Vol. 98, no. 2, pp. 157-162, 1996.
    • (1996) Cancer Letters , vol.98 , Issue.2 , pp. 157-162
    • Xia, Y.1    Muceniece, R.2    Wikberg, J.E.S.3
  • 70
    • 0029848043 scopus 로고    scopus 로고
    • Distribution of cDNA for melanocortin receptor subtypes in human tissues
    • V. Chhajlani, "Distribution of cDNA for melanocortin receptor subtypes in human tissues," Biochemistry and Molecular Biology International, Vol. 38, no. 1, pp. 73-80, 1996.
    • (1996) Biochemistry and Molecular Biology International , vol.38 , Issue.1 , pp. 73-80
    • Chhajlani, V.1
  • 71
    • 0033736084 scopus 로고    scopus 로고
    • New aspects on the melanocortins and their receptors
    • J. E. S. Wikberg, R. Muceniece, I. Mandrika et al., "New aspects on the melanocortins and their receptors," Pharmacological Research, Vol. 42, no. 5, pp. 393-420, 2000.
    • (2000) Pharmacological Research , vol.42 , Issue.5 , pp. 393-420
    • Wikberg, J.E.S.1    Muceniece, R.2    Mandrika, I.3
  • 72
    • 1542347163 scopus 로고    scopus 로고
    • Targeting melanocortin receptors as a novel strategy to control inflammation
    • A. Catania, S. Gatti, G. Colombo, and J. M. Lipton, "Targeting melanocortin receptors as a novel strategy to control inflammation," Pharmacological Reviews, Vol. 56, no. 1, pp. 1-29, 2004.
    • (2004) Pharmacological Reviews , vol.56 , Issue.1 , pp. 1-29
    • Catania, A.1    Gatti, S.2    Colombo, G.3    Lipton, J.M.4
  • 73
    • 78951495449 scopus 로고    scopus 로고
    • A pharmacotoxicological evaluation of a betulin topical formulation tested on C57BL/6J mouse experimental nevi and skin lesions
    • S. A. Ciurlea, C. Tiulea, E. Csanyi et al., "A pharmacotoxicological evaluation of a betulin topical formulation tested on C57BL/6J mouse experimental nevi and skin lesions," Studia Universitatis Vasile Goldis Arad, Seria Stiintele Vietii, Vol. 20, no. 4, pp. 5-9, 2010.
    • (2010) Studia Universitatis Vasile Goldis Arad, Seria Stiintele Vietii , vol.20 , Issue.4 , pp. 5-9
    • Ciurlea, S.A.1    Tiulea, C.2    Csanyi, E.3
  • 76
    • 59249107100 scopus 로고    scopus 로고
    • Treatment of actinic keratoses with a novel betulin-based oleogel. A prospective, randomized, comparative pilot study
    • C. Huyke, J. Reuter, M. Rödig et al., "Treatment of actinic keratoses with a novel betulin-based oleogel. A prospective, randomized, comparative pilot study," Journal of the German Society of Dermatology, Vol. 7, no. 2, pp. 128-134, 2009.
    • (2009) Journal of the German Society of Dermatology , vol.7 , Issue.2 , pp. 128-134
    • Huyke, C.1    Reuter, J.2    Rödig, M.3
  • 77
    • 0037231699 scopus 로고    scopus 로고
    • The actinic (solar) keratosis: A 21st-century perspective
    • W. Fu and C. J. Cocherell, "The actinic (solar) keratosis: a 21st-century perspective," Archives of Dermatology, Vol. 139, no. 1, pp. 66-70, 2003.
    • (2003) Archives of Dermatology , vol.139 , Issue.1 , pp. 66-70
    • Fu, W.1    Cocherell, C.J.2
  • 78
    • 84870944520 scopus 로고    scopus 로고
    • Current issues in the management of actinic keratosis
    • R. I. Ceilley and J. L. Jorizzo, "Current issues in the management of actinic keratosis," Journal of the American Academy of Dermatology, Vol. 68, no. 1, supplement 1, pp. S28-S38, 2013.
    • (2013) Journal of the American Academy of Dermatology , vol.68 , Issue.1 , pp. S28-S38
    • Ceilley, R.I.1    Jorizzo, J.L.2
  • 79
    • 0033927315 scopus 로고    scopus 로고
    • The risk of progression to invasive disease
    • R. G. Glogau, "The risk of progression to invasive disease," Journal of the American Academy of Dermatology, Vol. 42, no. 1, part 2, pp. S23-S24, 2000.
    • (2000) Journal of the American Academy of Dermatology , vol.42 , Issue.1 , pp. S23-S24
    • Glogau, R.G.1
  • 80
    • 77958592690 scopus 로고    scopus 로고
    • Physico-chemical and toxicological evaluations of betulin and betulinic acid interactions with hydrophilic cyclodextrins
    • C. M. Şoica, C. I. Peev, S. Ciurlea, R. Ambrus, and C. Dehelean, "Physico-chemical and toxicological evaluations of betulin and betulinic acid interactions with hydrophilic cyclodextrins," Farmacia, Vol. 58, no. 5, pp. 611-619, 2010.
    • (2010) Farmacia , vol.58 , Issue.5 , pp. 611-619
    • Şoica, C.M.1    Peev, C.I.2    Ciurlea, S.3    Ambrus, R.4    Dehelean, C.5
  • 81
    • 84860710546 scopus 로고    scopus 로고
    • A comparison investigation on the solubilization of betulin and betulinic acid in cyclodextrin derivatives
    • H. M. Wang, C. M. Şoica, and G. Wenz, "A comparison investigation on the solubilization of betulin and betulinic acid in cyclodextrin derivatives," Natural Product Communications, Vol. 7, no. 3, pp. 289-291, 2012.
    • (2012) Natural Product Communications , vol.7 , Issue.3 , pp. 289-291
    • Wang, H.M.1    Şoica, C.M.2    Wenz, G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.