Cytotoxic heterocyclic triterpenoids derived from betulin and betulinic acid

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 11, 2012, Pages 3666-3674

  Urban, Milan ^a,c   Vlk, Martin ^b   Dzubak, Petr ^c   Hajduch, Marian ^c   Sarek, Jan ^c  

^a UNIVERSITY OF COLORADO   (United States)

^b CZECH TECHNICAL UNIVERSITY IN PRAGUE   (Czech Republic)

^c PALACKÝ UNIVERSITY   (Czech Republic)

Author keywords

Bromination; Cytotoxicity; Diazotization; Heterocycles; Isoxazoles; Lupane; Oleanane; Pyrazoles; Thiazoles; Triterpenes

Indexed keywords

BETULIC ACID; BETULIN; HYDRAZINE; HYDROXYLAMINE; ISOXAZOLE; LUPEOL; PHENYLHYDRAZINE; PYRAZOLE; PYRAZOLONE; THIAZOLE; THIOUREA; TRITERPENOID;

ARTICLE; BIOLOGICAL ACTIVITY; CANCER CELL CULTURE; CHEMICAL REACTION; CHEMICAL STRUCTURE; CONTROLLED STUDY; CYTOTOXICITY; FIBROBLAST; PHENOTYPE; SYNTHESIS; TUMOR CELL;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL LINE, TUMOR; CRYSTALLOGRAPHY, X-RAY; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MOLECULAR STRUCTURE; OLEANOLIC ACID; STRUCTURE-ACTIVITY RELATIONSHIP; TRITERPENES;

EID: 84861196055     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.03.066     Document Type: Article

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