Antitumor activity of palmitic acid found as a selective cytotoxic substance in a marine red alga

Anticancer Research

Volumn 22, Issue 5, 2002, Pages 2587-2590

  Harada, Hideki ^a   Yamashita, Uki ^b   Kurihara, Hideyuki ^c   Fukushi, Eri ^c   Kawabata, Jun ^c   Kamei, Yuto ^a  

^a SAGA UNIVERSITY   (Japan)

^b UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

^c HOKKAIDO UNIVERSITY   (Japan)

Author keywords

Antitumor; Apoptosis; Marine alga; Palmitic acid; Selective cytotoxicity

Indexed keywords

ANTINEOPLASTIC AGENT; CYTOTOXIC AGENT; DNA TOPOISOMERASE; DNA TOPOISOMERASE (ATP HYDROLYSING); PALMITIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG SELECTIVITY; DRUG TARGETING; HUMAN; HUMAN CELL; LEUKEMIA CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; RED ALGA;

ALGAE, RED; ANIMALS; ANTINEOPLASTIC AGENTS; CELL DIVISION; DNA TOPOISOMERASES, TYPE I; DNA TOPOISOMERASES, TYPE II; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; HL-60 CELLS; HUMANS; K562 CELLS; LEUKEMIA; MICE; MICE, INBRED C3H; PALMITIC ACID;

EID: 0036765673     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Fenical W: New pharmaceuticals from marine organisms. Trend Biotech 15: 339-341, 1997.
2. Fujihara M, Iizima N, Yamamoto I and Nagumo T: Purification and chemical and physical characterisation of an antitumor polysaccharide from the brown seaweed Sargassum fulvellum. Carbohydr Res 125: 97-106, 1984.
3. Furusawa E and Furusawa S: Anticancer activity of a natural product, Viva-Natural, extracted from Undaria pinnnatifida on intraperitoneally implanted lewis lung carcinoma. Oncology 42: 364-369, 1985.
4. Itoh H, Noda H, Amano H, Zhuaug C, Mizuno T and Ito H: Antitumor activity and immunological properties of marine algal polysaccharides, especially fucoidan, prepared from Sargassum thunbergii of Phaeophyceae. Anticancer Res 13: 2045-2052, 1993.
5. Harada H, Noro T and Kamei Y: Selective antitumor activity in vitro from marine algae from Japan coasts. Biol Pharm Bull 20: 541-546, 1997.
6. Harada H, Noro T and Kamei Y: Selective cytotoxicity of marine algae extracts to several human leukemic cell lines. Cytotechnology 25: 213-219, 1997.
7. Mosmann T: Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J Immunol 65: 55-63, 1983.
8. Kerr JFR, Wyllie HA and Currie RA: Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 26: 239-257, 1972.
9. Schulze-Osthoff K, Ferrari D, Los M, Wesselborg S and Peter EM: Apoptosis signaling by death receptors. Eur J Biochem 254: 439-459, 1998.
10. Wyllie HA: Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature 284: 555-556, 1980.
11. Del BG, Skierski JS and Darzynkiewicz Z: Diverse effects of camptothecin, an inhibitor of topoisomerase I, on the cell cycle of lymphocytic (L1210, MOLT-4) and myelogenous (HL-60, KG1) leukemic cells. Cancer Res 50: 5746-5750, 1990.
12. Fusetani N and Hashimoto Y: Structures of two water soluble haemolysins isolated from the green alga Ulva pertusa. Agric Biol Chem 39: 2021-2025, 1976.
13. Jett M and Alving CR: Selective cytotoxicity of tumor cells induced by liposomes containing plant phosphatidylinositol. Biochem Biophys Res Commun 114: 863-871, 1983.
14. Singh JK, Dasgupta A, Adayev T, Shahmehdi SA, Hammond D and Banerjee P: Apoptosis is associated with an increase in saturated fatty acid containing phospholipids in the neuronal cell line, HN2-5. Biochim Biophys Acta 1304: 171-178, 1996.