Cranberry phytochemical extracts induce cell cycle arrest and apoptosis in human MCF-7 breast cancer cells

Cancer Letters

Volumn 241, Issue 1, 2006, Pages 124-134

  Sun, Jie ^a   Hai Liu, Rui ^a,b  

^a Department of Obstetrics Gynecology   (United States)

^b Institute for Comparative and Environmental Toxicology   (United States)

Author keywords

Anti proliferation; Apoptosis; Breast cancer; Cell cycle; Cranberries; Fruits and vegetables; Phytochemicals

Indexed keywords

ORNITHINE DECARBOXYLASE; PLANT EXTRACT;

APOPTOSIS; ARTICLE; BREAST TUMOR; CELL CYCLE; CHEMISTRY; CRANBERRY; DRUG EFFECT; ENZYMOLOGY; HUMAN; METABOLISM; PATHOLOGY; TUMOR CELL LINE; WESTERN BLOTTING;

APOPTOSIS; BLOTTING, WESTERN; BREAST NEOPLASMS; CELL CYCLE; CELL LINE, TUMOR; HUMANS; ORNITHINE DECARBOXYLASE; PLANT EXTRACTS; VACCINIUM MACROCARPON;

EID: 33845973448     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2005.10.027     Document Type: Article

References (55)

1. ACS Cancer Statistics 2004, A presentation from the American Cancer Society (Ed.), American Cancer Society Inc., Atlanta, 2004.
2. Lopez-Otin C., Diamandis E.P. Breast cancer and prostate cancer: an analysis of common epidemiological, genetic, and biochemical features. Endocr. Rev. 1998, 19:365-396.
3. Forbes J.F. The control of breast cancer: the role of tamoxifen. Semin. Oncol. 1997, 24(Suppl. 1):5-19.
4. Willet W.C. Diet, nutrition, and avoidable cancer. Environ. Health Perspect. 1995, 103:165-170.
5. Doll R., Peto R. Avoidable risks of cancer in the United States. J. Natl Cancer Inst. 1981, 66:1191-1308.
6. Hong W.K., Bacus J.W. Recent advances in chemoprevention of cancer. Science 1997, 278:1073-1077.
7. Block G., Patterson B., Subar A. Fruit, vegetables, and cancer prevention-a review of the epidemiologic evidence. Nutr. Cancer Int. J. 1992, 18:1-29.
8. Liu R.H. Health benefits of fruit and vegetables are from aditive and synergistic combinations of phytochemicals. Am. J. Clin. Nutr. 2003, 78:517s-520s.
9. Deschner E.E., Ruperto J., Wong G., Newmark H.L. Quercetin and rutin as inhibitors of azoxymethanol-induced colonic neoplasia. Carcinogenesis 1991, 7:1193-1196.
10. Wang H., Cao G.H., Prior R.L. Total antioxidant capacity of fruits. J. Agric. Food Chem. 1996, 44:701-705.
11. Birt D.F., Hendrich S., Wang W. Dietary agents in cancer prevention: flavonoids and isoflavonoids. Pharmacol. Ther. 2001, 90:157-177.
12. Freudenheim J.L., Marshall J.R., Vena J.E., Laughlin R., Brasure J.R., Swanson M.K., et al. Premenopausal breast cancer risk and intake of vegetables, fruits, and related nutrients. J. Natl Cancer Inst. 1996, 88:340-348.
13. Rock C.L., Demark-Wahnefried W. Nutrition and survival after the diagnosis of breast cancer: a review of the evidence. J. Clin. Oncol. 2002, 20:3302-3316.
14. Howe G.R., Hirohata T., Hislop T.G., Iscovich J.M., Yuan J.M., Katsouyanni K., et al. Dietary factors and risk of breast cancer: combined analysis of 12 case-control studies. J. Natl Cancer Inst. 1990, 82:561-569.
15. Colditz G., Lipnick R., Branch L., Willett W., Rosner B., Posner B., et al. Increased dietary carotene intake and lowered cancer deaths in an elderly population. Am. J. Epidemiol. 1983, 118:454.
16. Block G. Vitamin C and cancer prevention-the epidemiologic evidence. Am. J. Clin. Nutr. 1991, 53:S270-S282.
17. Hakkinen S., Heinonen M., Karenlampi S., Mykkanen H., Ruuskanen J., Torronen R. Screening of selected flavonoids and phenolic acids in 19 berries. Food Res. Int. 1999, 32:345-353.
18. Kandil F.E., Smith M.A.L., Rogers R.B., Pepin M.-F., Song L.L., Pezzuto J.M., et al. Composition of a chemopreventive proanthocyanidin-rich fraction from cranberry fruits responsible for the inhibition of 12-O-tetradecanoyl phorbol-13-acetate (TPA)-induced ornithine decarboxylase (ODC) activity. J. Agric. Food Chem. 2002, 50:1063-1069.
19. Liu R.H. Potential synergy of phytochemicals in cancer prevention: mechanism of action. J. Nutr. 2004, 134:3479S-3485S.
20. Howell A.B. Cranberry proanthocyanidins and the maintenance of urinary tract health. Crit. Rev. Food Sci. Nutr. 2002, 42:273-278.
21. Wilson T., Porcari J.P., Harbin D. Cranberry extract inhibits low density lipoprotein oxidation. Life Sci. 1998, 62:A381-A386.
22. Reed J. Cranberry flavonoids, atherosclerosis and cardiovascular health. Crit. Rev. Food Sci. Nutr. 2002, 42:301-316.
23. Sun J., Chu Y.-F., Wu X.Z., Liu R.H. Antioxidant and antiproliferative activities of common fruits. J. Agric. Food Chem. 2002, 50:7449-7454.
24. Chu Y.-F., Sun J., Wu X.Z., Liu R.H. Antioxidant and antiproliferative activities of vegetables. J. Agric. Food Chem. 2002, 50:6910-6916.
25. Decker E.A. The role of phenolics, conjugated linoleic-acid, carnosine, and pyrroloquinoline quinone as nonessential dietary antioxidants. Nutr. Rev. 1995, 53:49-58.
26. Seifried H.E., McDonald S.S., Andersen D.E., Greenwald P., Milner J.A. The antioxidant conundrum in cancer. Cancer Res. 2003, 63:4295-4298.
27. Tamimi R., Hankinson S., Campos H., Spiegelman D., Zhang S., Colditz G., et al. Plasma carotenoids, retinol and tocopherols and risk of breast cancer. Am. J. Epidemiol. 2005, 161:153-160.
28. Mo H., Elson C.E. Apoptosis and cell-cycle arrest in human and murine tumor cells are initiated by isoprenoids. J. Nutr. 1999, 129:804-813.
29. Agarwal C., Sharma Y., Agarwal R. Anticarcinogenic effect of a polyphnolic fracion isolatd from grape seeds in human prostate carcinoma DU145 cells: cell-cycle regulatiors and induction of G1 arrest and apoptosis. Mol. Carcinog. 2000, 28:129-138.
30. Chang W.-H., Liu J.-J., Ching-Hsein C., Huang T.-S., Lu F.-J. Growth inhibition and induction of apoptosis in MCF-7 breast cancer cells by fermented soy milk. Nutr. Cancer 2002, 43:214-226.
31. Behrens P., Brinkmann U., Wellmann A. CSE1L/CAS: its role in proliferation and apoptosis. Apoptosis 2003, 8:39-44.
32. Au J.L.-S., Panchal N., Li D., Gan Y. Apoptosis: a new pharmacodynamic endpoint. Pharm. Res. 1997, 14:1659-1671.
33. Kim Y.A., Choi B.T., Lee Y.T., Park D.I., Rhee S.H., Park K.Y., et al. Resveratrol inhibits cell proliferation and induces apoptosis of human breast carcinoma MCF-7 cells. Oncol. Rep. 2004, 11:441-446.
34. Dewanto V., Wu X.Z., Kafui K.A., Liu R.H. Thermal processing enhances the nutritional value of tomatoes by increasing total antioxidant activity. J. Agric. Food Chem. 2002, 50:3010-3014.
35. Singleton V.L., Orthofer R., Lamuela-Raventos R.M. Analysis of total phenols and other oxidation substrates and antioxidants by means of folin-ciocalteu reagent. Method Enzymol. 1999, 299:152-178.
36. Eberhardt M.V., Lee C.Y., Liu R.H. Antioxidant activity of fresh apples. Nature 2000, 405:903-904.
37. Wolfe K., Wu X.Z., Liu R.H. Antioxidant activity of apple peels. J. Agric. Food Chem. 2003, 51:609-614.
38. Liu M., Li X.Q., Weber C., Liu R.H. Antioxidant and antiproliferative activities of raspberries. J. Agric. Food Chem. 2002, 50:2926-2930.
39. Willet W.C. Diet and health: what should we eat?. Science 1994, 264:532-537.
40. Blot W.J., Li J.Y., Taylor P.R. Nutrition intervention trials in Linxian, China: supplementation with specific vitamin/mineral combinations, cancer incidence, and disease-specific mortality in the general population. J. Natl Cancer Inst. 1993, 85:1483-1492.
41. Salonen J.T., Nyysonen K., Salonen R. Antioxidant supplementation in atherosclerosis prevention (ASAP) study: a randomized trial of the effect of vitamins E and C on 3-year progression of carotid atherosclerosis. J. Intern. Med. 2000, 248:377-386.
42. Hennekens C.H., Buring J.E., Manson J.E., Stampfer M., Rosner B., Cook N.R., et al. Lack of effect of long-term supplementation with beta carotene on the incidence of malignant neoplasms and cardiovascular disease. N. Engl. J. Med. 1996, 334:1145-1149.
43. Greenberg E.R., Baron J.A., Stuckel T.A., Stevens M.M., Mandel J.S. A clinical trial of β-carotene to prevent basal cell and squamous cell cancer of the skin. N. Engl. J. Med. 1990, 323:789-795.
44. The alpha-tocopherol Beta-carotene Cancer Prevention Study Group The effect of vitamin E and β-carotene on the incidence of lung cancer and other cancers in male smokers. N. Engl. J. Med. 1994, 330:1029-1035.
45. Ommen G.S., Goodman G.E., Thornquist M.D. Effects of a combination of β-carotene and vitamin a on lung cancer and cardiovascular disease. N. Engl. J. Med. 1996, 334:1150-1155.
46. Bomser J., Madhavi D.L., Singletary K., Smith M.A. In vitro anticancer activity of fruit extracts from vaccinium species. Planta Med. 1996, 62:212-216.
47. Ferguson P.J., Kurowska E., Freeman D., Chambers A., Koropatnick D.J. Cranberry constituents and prostate cancer cell growth. J. Nutr. 2003, 133:3843S-3850S.
48. Dixon S.C., Sorianon B.J., Lush R.M., Borner M.M., Figg W.D. Apoptosis: its role in the development of malignancies and its potential as a novel therapeutic target. Ann. Pharmacother. 1997, 31:76-82.
49. Surh Y.-J. Molecular mechanism of chemopreventive effects of selected dietary and medicinal phenolic substances. Mutat. Res. 1999, 428:305-327.
50. Hartwell L.H., Kastan M.B. Cell cycle control and cancer. Science 1994, 266:1821-1828.
51. Huschtscha L.I., Bartier W.A., Anderson Ross C.E., Tattersall M.H.N. Characteristics of cancer cell death after exposure to cytotoxic drugs in vitro. Br. J. Cancer 1996, 73:54-60.
52. Sorensen C., Charpentier R., Benson E. Cell cycle regulatory proteins and structural proteins as markers of apoptosis. Am. Biotechnol. Lab. 2000, 17:20-22.
53. Harbour J.W., Dean D.C. Rb function in cell-cycle regulation and apoptosis. Nat. Cell Biol. 2000, 2:E65-E67.
54. Harper J.W., Elledge S.J., Keyomarsi K., Dynlacht G., Tsai L.H., Zhang P., et al. Inhibition of cyclin-dependent kinases by p21. Mol. Biol. Cell 1995, 6:387-400.
55. Liu R.H., Liu J., Chen B. Apples prevent mammary tumors in rats. J. Agric. Food Chem. 2005, 53:2341-2343.