Treatment of actinic keratoses with birch bark extract: A pilot study

JDDG - Journal of the German Society of Dermatology

Volumn 4, Issue 2, 2006, Pages 132-136

  Huyke, Constance ^a   Laszczyk, Melanie ^b   Scheffler, Armin ^b   Ernst, Reinhard ^c   Schempp, Christoph M ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b Birken GmbH

^c Hospitalstr 8   (Germany)

Author keywords

Actinic keratoses; Betulin; Betulinic acid; Oleanolic acid

Indexed keywords

BIRCH BARK EXTRACT; PLANT EXTRACT; UNCLASSIFIED DRUG;

ACTINIC KERATOSIS; ADULT; AGED; APOPTOSIS; BIRCH; CLINICAL ARTICLE; CLINICAL EXAMINATION; CLINICAL TRIAL; CONFERENCE PAPER; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CRYOTHERAPY; FEMALE; HUMAN; MALE; STANDARDIZATION; ARTICLE; FOLLOW UP; MIDDLE AGED; MULTIMODALITY CANCER THERAPY; OINTMENT; PHOTOSENSITIVITY DISORDER; PHYTOTHERAPY; PILOT STUDY; PROSPECTIVE STUDY;

AGED; BETULA; COMBINED MODALITY THERAPY; CRYOTHERAPY; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; MIDDLE AGED; OINTMENTS; PHOTOSENSITIVITY DISORDERS; PHYTOTHERAPY; PILOT PROJECTS; PLANT EXTRACTS; PROSPECTIVE STUDIES;

EID: 33645220995     PISSN: 16100379     EISSN: 16100387     Source Type: Journal    
DOI: 10.1111/j.1610-0387.2006.05906.x     Document Type: Conference Paper

References (37)

1. Aiken C, Chen CH. Betulinic acid derivatives as HIV-1 antivirals. Trends Mol Med 2005;11: 31-36.
2. Babilas P, Landthaler M, Szeimies RM. Die aktinische Keratose. Hautarzt 2003; 54: 551-560.
3. Baskar R. Effect of lupeol isolated from Crataeva nurvula stem bark against free radical-induced toxicity in experimental urolithiasis. Fitoterapia 1996; LXVII: 121-125.
4. Cairnduff F, Stringer MR, Hudson EJ, Ash DV, Brown SB. Superficial photodynamic therapy with topical 5-aminolaevulinic acid for superficial primary and secondary skin cancer. Br J Cancer 1994; 69: 605-608.
5. Eiznhamer DA, Xu ZQ. Betulinic acid: a promising anticancer candidate. ID-rugs 2004; 7: 359-373.
6. Fernandez A. New insights into the mechanism of action of the antiinflammatory triterpene Lupeol. J Pharm Pharmacol 2001; 53: 1533-1539.
7. Freeman M, Vinciullo C, Francis D, Spelman L, Nguyen R, Fergin P, Thai KE, Murrell D, Weightman W, Anderson C, Reid C, Watson A, Foley P. A comparison of photodynamic therapy using topical methyl aminolevulinate (Metvix) with single cycle cryotherapy in patients with actinic keratosis: a prospective, randomized study. J Dermatolog Treat 2003; 14: 99-106.
8. Fu W, Cockerell CJ. The actinic (solar) keratosis: a 21st-century perspective. Arch Dermatol 2003; 139: 66-70.
9. Fulda S, Jeremias I, Steiner HH, Pietsch T, Debatin KM. Betulinic acid: a new cytotoxic agent against malignant brain-tumor cells. Int J Cancer 1999; 82: 435-441.
10. Fulda S, Scaffidi C, Susin SA, Krammer PH, Kroemer G, Peter ME, Debatin KM. Activation of mitochondria and release of mitochondrial apoptogenic factors by betulinic acid. J Biol Chem 1998; 273: 33942-33948.
11. Gebauer K, Brown P, Varigos G. Topical diclofenac in hyaluronan gel for the treatment of solar keratoses. Australas J Dermatol 2003; 44: 40-43.
12. Geetha T. Effect of triterpenes from Crataeva nurvula stem bark on lipid peroxidation in adjuvant induced arthritis in rats. Pharmacol Res 1998; 37: 191-195.
13. Giner-Larza EM, Manez S, Recio MC, Giner RM, Prieto JM, Cerda-Nicolas M, Rios JL. Oleanolic acid, a 3-oxotriterpene from Pistacia, inhibits leukotriene synthesis and has anti-inflammatory activity. Eur J Pharmacol 2001; 428: 137-143.
14. Glogau RG. The risk of progression to invasive disease. J Am Acad Dermatol 2000; 42: 23-24.
15. Jay V. An innovative ingredient for a better skin protection. SOFW Journal 2000; 126: 24-27.
16. Jiang SB, Levine VJ, Nehal KS, Baldassano M, Kamino H, Ashinoff RA. Er:YAG laser for the treatment of actinic keratoses. Dermatol Surg 2000; 26: 437-440.
17. Jorizzo J, Weiss J, Furst K, VandePol C, Levy SF. Effect of a 1-week treatment with 0.5% topical fluorouracil on occurrence of actinic keratosis after cryosurgery: a randomized, vehicle-controlled clinical trial. Arch Dermatol 2004; 140: 813-816.
18. Lebwohl M, Dinehart S, Whiting D, Lee PK, Tawfik N, Jorizzo J, Lee JH, Fox TL. Imiquimod 5% cream for the treatment of actinic keratosis: results from two phase III, randomized, double-blind, parallel group, vehicle-controlled trials. J Am Acad Dermatol 2004; 50: 714-721.
19. Loven K, Stein L, Furst K, Levy S. Evaluation of the efficacy and tolerability of 0.5% fluorouracil cream and 5% fluorouracil cream applied to each side of the face in patients with actinic keratosis. Clin Ther 2002; 24: 990-1000.
20. Memon AA, Tomenson JA, Bothwell J, Friedmann PS. Prevalence of solar damage and actinic keratosis in a Merseyside population. Br J Dermatol 2000; 142: 1154-1159.
21. Nelson C, Rigel D, Smith S, Swanson N, Wolf J. Phase IV, open-label assessment of the treatment of actinic keratosis with 3.0% diclofenac sodium topical gel (Solaraze). J Drugs Dermatol 2004; 3: 401-407.
22. Ortonne JP. From actinic keratosis to squamous cell carcinoma. Br J Dermatol 2002; 146 Suppl 61: 20-23.
23. Pariser DM, Lowe NJ, Stewart DM, Jarratt MT, Lucky AW, Pariser RJ, Yamauchi PS. Photodynamic therapy with topical methyl aminolevulinate for actinic keratosis: results of a prospective randomized multicenter trial. J Am Acad Dermatol 2003; 48: 227-232.
24. Pisha E, Chai H, Lee IS, Chagwedera TE, Farnsworth NR, Cordell GA, Beecher CW, Fong HH, Kinghorn AD, Brown DM. Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis. Nat Med 1995; 1: 1046-1051.
25. Recio MC, Giner RM, Manez S, Gueho J, Julien HR, Hostettmann K, Rios JL. Investigations on the steroidal anti-inflammatory activity of triterpenoids from Diospyros leucomelas. Planta Med 1995; 61: 9-12.
26. Schwartz RA. The actinic keratosis. A perspective and update. Dermatol Surg 1997; 23: 1009-1019.
27. Selzer E, Pimentel E, Wacheck V, Schlegel W, Pehamberger H, Jansen B, Kodym R. Effects of betulinic acid alone and in combination with irradiation in human melanoma cells. J Invest Dermatol 2000; 114: 935-940.
28. Stockfleth E, Meyer T, Benninghoff B, Salasche S, Papadopoulos L, Ulrich C, Christophers E. A randomized, double-blind, vehicle-controlled study to assess 5% imiquimod cream for the treatment of multiple actinic keratoses. Arch Dermatol 2002; 138: 1498-1502.
29. Szeimies RM, Gerritsen MJ, Gupta G, Ortonne JP, Serresi S, Bichel J, Lee JH, Fox TL, Alomar A. Imiquimod 5% cream for the treatment of actinic keratosis: results from a phase III, randomized, double-blind, vehicle-controlled, clinical trial with histology. J Am Acad Dermatol 2004; 51: 547-555.
30. Szeimies RM, Karrer S, Backer H. Therapieoptionen bei epithelialen Hauttumoren. Aktinische Keratosen, Morbus Bowen, spinozelluläres Karzinom und Basalzellkarzinom. Hautarzt 2005; 56(5): 430-440.
31. Szeimies RM, Karrer S, Radakovic-Fijan S, Tanew A, Calzavara-Pinton PG, Zane C, Sidoroff A, Hempel M, Ulrich J, Proebstle T, Meffert H, Mulder M, Salomon D, Dittmar HC, Bauer JW, Kernland K, Braathen L. Photodynamic therapy using topical methyl 5-aminolevulinate compared with cryotherapy for actinic keratosis: A prospective, randomized study. J Am Acad Dermatol 2002; 47: 258-262.
32. Takada Y, Aggarwal B. Betulinic acid suppresses carcinogen-induced NF-kappa B activation through inhibition of I kappa B alpha kinase and p65 phosphorylation: abrogation of cyclooxygenase-2 and matrix metalloprotease-9. J Immunol 2003; 171: 3278-3286.
33. Wang BH, Polya GM. Selective inhibition of cyclic AMP-dependent protein kinase by amphophilic triterpenoids and related compounds. Phytochemistry 1996; 41: 55-63.
34. Wolf JE Jr, Taylor JR, Tschen E, Kang S. Topical 3.0% diclofenac in 2.5% hyaluronan gel in the treatment of actinic keratoses. Int J Dermatol 2001; 40: 709-713.
35. Yasukawa K, Takido M, Matsumoto T, Takeuchi M, Nakagawa S. Sterol and triterpene derivatives from plants inhibit the effects of a tumor promoter, and sitosterol and betulinic acid inhibit tumor formation in mouse skin two-stage carcinogenesis. Oncology 1991; 48: 72-76.
36. Ying Q L, Rinehart AR, Simon SR, Cheronis JC. Inhibition of human leucocyte elastase by ursolic acid. Evidence for a binding site for pentacyclic triterpenes. Biochem J 1991; 277: 521-526.
37. Zouboulis CC, Rohrs H. Kryotherapeutische Behandlung aktinischer Keratosen mit evidenzbasierter Übersicht. Hautarzt 2005; 56: 353-359.