Betulin is a potent anti-tumor agent that is enhanced-by cholesterol

PLoS ONE

Volumn 4, Issue 4, 2009, Pages

  Mullauer, Franziska B ^a   Kessler, Jan H ^a,b   Medema, Jan Paul ^a  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BETULIC ACID; BETULIN; CHOLESTEROL; CYCLOSPORIN A; CYTOCHROME C; BAK1 PROTEIN, MOUSE; BAX PROTEIN, MOUSE; CYCLOSPORIN; FADD PROTEIN, HUMAN; FAS ASSOCIATED DEATH DOMAIN PROTEIN; PROTEIN BAK; PROTEIN BAX; REACTIVE OXYGEN METABOLITE; TRITERPENE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DNA FRAGMENTATION; DRUG MECHANISM; DRUG POTENTIATION; ENZYME RELEASE; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; HUMAN CELL; IMMUNOBLOTTING; LEUKEMIA CELL LINE; WESTERN BLOTTING; ANIMAL; CELL CULTURE; CELL LINE; DRUG EFFECT; GENE EXPRESSION; GENETICS; HELA CELL; METABOLISM; MOUSE; MOUSE MUTANT; PROTO ONCOGENE;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BCL-2-ASSOCIATED X PROTEIN; CELL LINE; CELLS, CULTURED; CHOLESTEROL; CYCLOSPORINE; DRUG SYNERGISM; FAS-ASSOCIATED DEATH DOMAIN PROTEIN; GENE EXPRESSION; GENES, BCL-2; HELA CELLS; HUMANS; JURKAT CELLS; MICE; MICE, KNOCKOUT; REACTIVE OXYGEN SPECIES; TRITERPENES;

EID: 65449179903     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0005361     Document Type: Article

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