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Volumn 45, Issue 4, 2015, Pages 1150-1162

The innate immune function of airway epithelial cells in inflammatory lung disease

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; CELL RECEPTOR; LECTIN RECEPTOR; MUCIN 5B; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR; POLYPEPTIDE ANTIBIOTIC AGENT; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE; RETINOIC ACID INDUCIBLE PROTEIN I; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 10; TOLL LIKE RECEPTOR 11; TOLL LIKE RECEPTOR 12; TOLL LIKE RECEPTOR 13; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 5; TOLL LIKE RECEPTOR 6; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; TOLL LIKE RECEPTOR 9; UNCLASSIFIED DRUG;

EID: 84926500091     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/09031936.00141514     Document Type: Article
Times cited : (299)

References (120)
  • 1
    • 1042269503 scopus 로고    scopus 로고
    • Innate immunity in the lung: How epithelial cells fight against respiratory pathogens
    • Bals R, Hiemstra PS. Innate immunity in the lung: how epithelial cells fight against respiratory pathogens. Eur Respir J 2004; 23: 327-333.
    • (2004) Eur Respir J , vol.23 , pp. 327-333
    • Bals, R.1    Hiemstra, P.S.2
  • 2
    • 80051626877 scopus 로고    scopus 로고
    • Innate immunity in the respiratory epithelium
    • Parker D, Prince A. Innate immunity in the respiratory epithelium. Am J Respir Cell Mol Biol 2011; 45: 189-201.
    • (2011) Am J Respir Cell Mol Biol , vol.45 , pp. 189-201
    • Parker, D.1    Prince, A.2
  • 3
    • 84876942956 scopus 로고    scopus 로고
    • NKX2-1 activation by SMAD2 signaling after definitive endoderm differentiation in human embryonic stem cell
    • Li Y, Eggermont K, Vanslembrouck V, et al. NKX2-1 activation by SMAD2 signaling after definitive endoderm differentiation in human embryonic stem cell. Stem Cells Dev 2013; 22: 1433-1442.
    • (2013) Stem Cells Dev , vol.22 , pp. 1433-1442
    • Li, Y.1    Eggermont, K.2    Vanslembrouck, V.3
  • 4
    • 84866067664 scopus 로고    scopus 로고
    • Directed differentiation of human pluripotent stem cells into mature airway epithelia expressing functional CFTR protein
    • Wong AP, Bear CE, Chin S, et al. Directed differentiation of human pluripotent stem cells into mature airway epithelia expressing functional CFTR protein. Nat Biotechnol 2012; 30: 876-882.
    • (2012) Nat Biotechnol , vol.30 , pp. 876-882
    • Wong, A.P.1    Bear, C.E.2    Chin, S.3
  • 5
    • 84899644608 scopus 로고    scopus 로고
    • Generation of multiciliated cells in functional airway epithelia from human induced pluripotent stem cells
    • Firth AL, Dargitz CT, Qualls SJ, et al. Generation of multiciliated cells in functional airway epithelia from human induced pluripotent stem cells. Proc Natl Acad Sci USA 2014; 111: E1723-E1730.
    • (2014) Proc Natl Acad Sci USA , vol.111 , pp. E1723-E1730
    • Firth, A.L.1    Dargitz, C.T.2    Qualls, S.J.3
  • 6
    • 80054030182 scopus 로고    scopus 로고
    • Epithelial progenitor cells in lung development, maintenance, repair, and disease
    • Rock JR, Hogan BL. Epithelial progenitor cells in lung development, maintenance, repair, and disease. Annu Rev Cell Dev Biol 2011; 27: 493-512.
    • (2011) Annu Rev Cell Dev Biol , vol.27 , pp. 493-512
    • Rock, J.R.1    Hogan, B.L.2
  • 7
    • 84892748994 scopus 로고    scopus 로고
    • Lung development: Orchestrating the generation and regeneration of a complex organ
    • Herriges M, Morrisey EE. Lung development: orchestrating the generation and regeneration of a complex organ. Development 2014; 141: 502-513.
    • (2014) Development , vol.141 , pp. 502-513
    • Herriges, M.1    Morrisey, E.E.2
  • 8
    • 84874045371 scopus 로고    scopus 로고
    • Stem cells of the adult lung: Their development and role in homeostasis, regeneration, and disease
    • Wansleeben C, Barkauskas CE, Rock JR, et al. Stem cells of the adult lung: their development and role in homeostasis, regeneration, and disease. Wiley Interdiscip Rev Dev Biol 2013; 2: 131-148.
    • (2013) Wiley Interdiscip Rev Dev Biol , vol.2 , pp. 131-148
    • Wansleeben, C.1    Barkauskas, C.E.2    Rock, J.R.3
  • 9
    • 69149106207 scopus 로고    scopus 로고
    • Basal cells as stem cells of the mouse trachea and human airway epithelium
    • Rock JR, Onaitis MW, Rawlins EL, et al. Basal cells as stem cells of the mouse trachea and human airway epithelium. Proc Natl Acad Sci USA 2009; 106: 12771-12775.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 12771-12775
    • Rock, J.R.1    Onaitis, M.W.2    Rawlins, E.L.3
  • 10
    • 84887619426 scopus 로고    scopus 로고
    • Dedifferentiation of committed epithelial cells into stem cells in vivo
    • Tata PR, Mou H, Pardo-Saganta A, et al. Dedifferentiation of committed epithelial cells into stem cells in vivo. Nature 2013; 503: 218-223.
    • (2013) Nature , vol.503 , pp. 218-223
    • Tata, P.R.1    Mou, H.2    Pardo-Saganta, A.3
  • 13
    • 33144457798 scopus 로고    scopus 로고
    • Dicer function is essential for lung epithelium morphogenesis
    • Harris KS, Zhang Z, McManus MT, et al. Dicer function is essential for lung epithelium morphogenesis. Proc Natl Acad Sci USA 2006; 103: 2208-2213.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 2208-2213
    • Harris, K.S.1    Zhang, Z.2    McManus, M.T.3
  • 14
    • 67651240360 scopus 로고    scopus 로고
    • MicroRNA expression profiling in mild asthmatic human airways and effect of corticosteroid therapy
    • Williams AE, Larner-Svensson H, Perry MM, et al. MicroRNA expression profiling in mild asthmatic human airways and effect of corticosteroid therapy. PLoS One 2009; 4: e5889.
    • (2009) PLoS One , vol.4 , pp. e5889
    • Williams, A.E.1    Larner-Svensson, H.2    Perry, M.M.3
  • 15
    • 84870502577 scopus 로고    scopus 로고
    • Human nasal and tracheo-bronchial respiratory epithelial cell culture
    • Fulcher ML, Randell SH. Human nasal and tracheo-bronchial respiratory epithelial cell culture. Methods Mol Biol 2013; 945: 109-121.
    • (2013) Methods Mol Biol , vol.945 , pp. 109-121
    • Fulcher, M.L.1    Randell, S.H.2
  • 16
    • 78650653743 scopus 로고    scopus 로고
    • The air-liquid interface and use of primary cell cultures are important to recapitulate the transcriptional profile of in vivo airway epithelia
    • Pezzulo AA, Starner TD, Scheetz TE, et al. The air-liquid interface and use of primary cell cultures are important to recapitulate the transcriptional profile of in vivo airway epithelia. Am J Physiol 2011; 300: L25-L31.
    • (2011) Am J Physiol , vol.300 , pp. L25-L31
    • Pezzulo, A.A.1    Starner, T.D.2    Scheetz, T.E.3
  • 17
    • 78650676408 scopus 로고    scopus 로고
    • Do airway epithelium air-liquid cultures represent the in vivo airway epithelium transcriptome?
    • Dvorak A, Tilley AE, Shaykhiev R, et al. Do airway epithelium air-liquid cultures represent the in vivo airway epithelium transcriptome? Am J Respir Cell Mol Biol 2011; 44: 465-473.
    • (2011) Am J Respir Cell Mol Biol , vol.44 , pp. 465-473
    • Dvorak, A.1    Tilley, A.E.2    Shaykhiev, R.3
  • 18
    • 84922786141 scopus 로고    scopus 로고
    • Applications of mouse airway epithelial cell culture for asthma research
    • Allen IC, ed. Totowa, NJ, Humana Press
    • Horani A, Dickinson J, Brody S. Applications of mouse airway epithelial cell culture for asthma research. In: Allen IC, ed. Mouse Models of Allergic Disease: Methods and Protocols. Totowa, NJ, Humana Press, 2013; pp. 91-107.
    • (2013) Mouse Models of Allergic Disease: Methods and Protocols , pp. 91-107
    • Horani, A.1    Dickinson, J.2    Brody, S.3
  • 19
    • 84870599083 scopus 로고    scopus 로고
    • Conditionally reprogrammed cells represent a stem-like state of adult epithelial cells
    • Suprynowicz FA, Upadhyay G, Krawczyk E, et al. Conditionally reprogrammed cells represent a stem-like state of adult epithelial cells. Proc Natl Acad Sci USA 2012; 109: 20035-20040.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 20035-20040
    • Suprynowicz, F.A.1    Upadhyay, G.2    Krawczyk, E.3
  • 20
    • 84883473051 scopus 로고    scopus 로고
    • Rho-associated protein kinase inhibition enhances airway epithelial basal-cell proliferation and lentivirus transduction
    • Horani A, Nath A, Wasserman MG, et al. Rho-associated protein kinase inhibition enhances airway epithelial basal-cell proliferation and lentivirus transduction. Am J Respir Cell Mol Biol 2013; 49: 341-347.
    • (2013) Am J Respir Cell Mol Biol , vol.49 , pp. 341-347
    • Horani, A.1    Nath, A.2    Wasserman, M.G.3
  • 21
    • 84879264708 scopus 로고    scopus 로고
    • ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering
    • Gaj T, Gersbach CA, Barbas CF III. ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering. Trends Biotechnol 2013; 31: 397-405.
    • (2013) Trends Biotechnol , vol.31 , pp. 397-405
    • Gaj, T.1    Gersbach, C.A.2    Barbas, C.F.3
  • 22
    • 70449713952 scopus 로고    scopus 로고
    • The NIH Human Microbiome Project
    • Peterson J, Garges S, Giovanni M, et al. The NIH Human Microbiome Project. Genome Res 2009; 19: 2317-2323.
    • (2009) Genome Res , vol.19 , pp. 2317-2323
    • Peterson, J.1    Garges, S.2    Giovanni, M.3
  • 23
    • 84874733216 scopus 로고    scopus 로고
    • Microbes and mucosal immune responses in asthma
    • Hansel TT, Johnston SL, Openshaw PJ. Microbes and mucosal immune responses in asthma. Lancet 2013; 381: 861-873.
    • (2013) Lancet , vol.381 , pp. 861-873
    • Hansel, T.T.1    Johnston, S.L.2    Openshaw, P.J.3
  • 25
    • 84902201196 scopus 로고    scopus 로고
    • Lung microbiota promotes tolerance to allergens in neonates via PD-L1
    • Gollwitzer ES, Saglani S, Trompette A, et al. Lung microbiota promotes tolerance to allergens in neonates via PD-L1. Nat Med 2014; 20: 642-647.
    • (2014) Nat Med , vol.20 , pp. 642-647
    • Gollwitzer, E.S.1    Saglani, S.2    Trompette, A.3
  • 26
    • 79960886859 scopus 로고    scopus 로고
    • Culture enriched molecular profiling of the cystic fibrosis airway microbiome
    • Sibley CD, Grinwis ME, Field TR, et al. Culture enriched molecular profiling of the cystic fibrosis airway microbiome. PLoS One 2011; 6: e22702.
    • (2011) PLoS One , vol.6 , pp. e22702
    • Sibley, C.D.1    Grinwis, M.E.2    Field, T.R.3
  • 27
    • 79958069364 scopus 로고    scopus 로고
    • The airway microbiome in cystic fibrosis and implications for treatment
    • Zemanick ET, Sagel SD, Harris JK. The airway microbiome in cystic fibrosis and implications for treatment. Curr Opin Pediatr 2011; 23: 319-324.
    • (2011) Curr Opin Pediatr , vol.23 , pp. 319-324
    • Zemanick, E.T.1    Sagel, S.D.2    Harris, J.K.3
  • 28
    • 84887874141 scopus 로고    scopus 로고
    • Outgrowth of the bacterial airway microbiome after rhinovirus exacerbation of chronic obstructive pulmonary disease
    • Molyneaux PL, Mallia P, Cox MJ, et al. Outgrowth of the bacterial airway microbiome after rhinovirus exacerbation of chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2013; 188: 1224-1231.
    • (2013) Am J Respir Crit Care Med , vol.188 , pp. 1224-1231
    • Molyneaux, P.L.1    Mallia, P.2    Cox, M.J.3
  • 29
    • 84892476369 scopus 로고    scopus 로고
    • Alterations in the microbiota drive interleukin-17C production from intestinal epithelial cells to promote tumorigenesis
    • Song X, Gao H, Lin Y, et al. Alterations in the microbiota drive interleukin-17C production from intestinal epithelial cells to promote tumorigenesis. Immunity 2014; 40: 140-152.
    • (2014) Immunity , vol.40 , pp. 140-152
    • Song, X.1    Gao, H.2    Lin, Y.3
  • 30
    • 84884178416 scopus 로고    scopus 로고
    • Abundant DNase I-sensitive bacterial DNA in healthy porcine lungs and its implications for the lung microbiome
    • Pezzulo AA, Kelly PH, Nassar BS, et al. Abundant DNase I-sensitive bacterial DNA in healthy porcine lungs and its implications for the lung microbiome. Appl Environ Microbiol 2013; 79: 5936-5941.
    • (2013) Appl Environ Microbiol , vol.79 , pp. 5936-5941
    • Pezzulo, A.A.1    Kelly, P.H.2    Nassar, B.S.3
  • 31
    • 0024955886 scopus 로고
    • Approaching the asymptote? Evolution and revolution in immunology
    • Janeway CA Jr. Approaching the asymptote? Evolution and revolution in immunology. Cold Spring Harb Symp Quant Biol 1989; 54: 1-13.
    • (1989) Cold Spring Harb Symp Quant Biol , vol.54 , pp. 1-13
    • Janeway, C.A.1
  • 32
    • 77950343791 scopus 로고    scopus 로고
    • Pattern recognition receptors and inflammation
    • Takeuchi O, Akira S. Pattern recognition receptors and inflammation. Cell 2010; 140: 805-820.
    • (2010) Cell , vol.140 , pp. 805-820
    • Takeuchi, O.1    Akira, S.2
  • 33
    • 84878232476 scopus 로고    scopus 로고
    • The history of Toll-like receptors - Redefining innate immunity
    • O'Neill LA, Golenbock D, Bowie AG. The history of Toll-like receptors - redefining innate immunity. Nat Rev Immunol 2013; 13: 453-460.
    • (2013) Nat Rev Immunol , vol.13 , pp. 453-460
    • O'Neill, L.A.1    Golenbock, D.2    Bowie, A.G.3
  • 34
    • 0022230197 scopus 로고
    • Establishment of dorsal-ventral polarity in the Drosophila embryo: Genetic studies on the role of the Toll gene product
    • Anderson KV, Jurgens G, Nusslein-Volhard C. Establishment of dorsal-ventral polarity in the Drosophila embryo: genetic studies on the role of the Toll gene product. Cell 1985; 42: 779-789.
    • (1985) Cell , vol.42 , pp. 779-789
    • Anderson, K.V.1    Jurgens, G.2    Nusslein-Volhard, C.3
  • 35
    • 30944461373 scopus 로고    scopus 로고
    • Toll-like receptor expression and function in airway epithelial cells
    • Greene CM, McElvaney NG. Toll-like receptor expression and function in airway epithelial cells. Arch Immunol Ther Exp (Warsz) 2005; 53: 418-427.
    • (2005) Arch Immunol Ther Exp (Warsz) , vol.53 , pp. 418-427
    • Greene, C.M.1    McElvaney, N.G.2
  • 36
    • 4444292595 scopus 로고    scopus 로고
    • Activation of airway epithelial cells by toll-like receptor agonists
    • Sha Q, Truong-Tran AQ, Plitt JR, et al. Activation of airway epithelial cells by toll-like receptor agonists. Am J Respir Cell Mol Biol 2004; 31: 358-364.
    • (2004) Am J Respir Cell Mol Biol , vol.31 , pp. 358-364
    • Sha, Q.1    Truong-Tran, A.Q.2    Plitt, J.R.3
  • 37
    • 76149121169 scopus 로고    scopus 로고
    • Myeloid RelA regulates pulmonary host defense networks
    • Hess C, Herr C, Beisswenger C, et al. Myeloid RelA regulates pulmonary host defense networks. Eur Respir J 2010; 35: 343-352.
    • (2010) Eur Respir J , vol.35 , pp. 343-352
    • Hess, C.1    Herr, C.2    Beisswenger, C.3
  • 38
    • 33846307747 scopus 로고    scopus 로고
    • Myeloid C-type lectins in innate immunity
    • Robinson MJ, Sancho D, Slack EC, et al. Myeloid C-type lectins in innate immunity. Nat Immunol 2006; 7: 1258-1265.
    • (2006) Nat Immunol , vol.7 , pp. 1258-1265
    • Robinson, M.J.1    Sancho, D.2    Slack, E.C.3
  • 39
    • 72849108071 scopus 로고    scopus 로고
    • Dectin-1 is inducible and plays an essential role for mycobacteria-induced innate immune responses in airway epithelial cells
    • Lee HM, Yuk JM, Shin DM, et al. Dectin-1 is inducible and plays an essential role for mycobacteria-induced innate immune responses in airway epithelial cells. J Clin Immunol 2009; 29: 795-805.
    • (2009) J Clin Immunol , vol.29 , pp. 795-805
    • Lee, H.M.1    Yuk, J.M.2    Shin, D.M.3
  • 40
    • 84869125263 scopus 로고    scopus 로고
    • Dectin-1 is inducible and plays a crucial role in Aspergillus-induced innate immune responses in human bronchial epithelial cells
    • Sun WK, Lu X, Li X, et al. Dectin-1 is inducible and plays a crucial role in Aspergillus-induced innate immune responses in human bronchial epithelial cells. Eur J Clin Microbiol Infect Dis 2012; 31: 2755-2764.
    • (2012) Eur J Clin Microbiol Infect Dis , vol.31 , pp. 2755-2764
    • Sun, W.K.1    Lu, X.2    Li, X.3
  • 41
    • 73349104638 scopus 로고    scopus 로고
    • Role of double-stranded RNA pattern recognition receptors in rhinovirus-induced airway epithelial cell responses
    • Wang Q, Nagarkar DR, Bowman ER, et al. Role of double-stranded RNA pattern recognition receptors in rhinovirus-induced airway epithelial cell responses. J Immunol 2009; 183: 6989-6997.
    • (2009) J Immunol , vol.183 , pp. 6989-6997
    • Wang, Q.1    Nagarkar, D.R.2    Bowman, E.R.3
  • 42
    • 84892164939 scopus 로고    scopus 로고
    • Debug your bugs - How NLRs shape intestinal host-microbe interactions
    • Lipinski S, Rosenstiel P. Debug your bugs - how NLRs shape intestinal host-microbe interactions. Front Immunol 2013; 4: 479.
    • (2013) Front Immunol , vol.4 , pp. 479
    • Lipinski, S.1    Rosenstiel, P.2
  • 44
    • 79952634089 scopus 로고    scopus 로고
    • The unfolded protein response in lung disease
    • Marcinak SJ, Ron D. The unfolded protein response in lung disease. Proc Am Thorac Soc 2010; 7: 356-362.
    • (2010) Proc Am Thorac Soc , vol.7 , pp. 356-362
    • Marcinak, S.J.1    Ron, D.2
  • 45
    • 84877587978 scopus 로고    scopus 로고
    • Mapping the crossroads of immune activation and cellular stress response pathways
    • Claudio N, Dalet A, Gatti E, et al. Mapping the crossroads of immune activation and cellular stress response pathways. EMBO J 2013; 32: 1214-1224.
    • (2013) EMBO J , vol.32 , pp. 1214-1224
    • Claudio, N.1    Dalet, A.2    Gatti, E.3
  • 46
    • 84857546470 scopus 로고    scopus 로고
    • Beyond pattern recognition: Five immune checkpoints for scaling the microbial threat
    • Blander JM, Sander LE. Beyond pattern recognition: five immune checkpoints for scaling the microbial threat. Nat Rev Immunol 2012; 12: 215-225.
    • (2012) Nat Rev Immunol , vol.12 , pp. 215-225
    • Blander, J.M.1    Sander, L.E.2
  • 47
    • 84896770768 scopus 로고    scopus 로고
    • Bitter and sweet taste receptors regulate human upper respiratory innate immunity
    • Lee RJ, Kofonow JM, Rosen PL, et al. Bitter and sweet taste receptors regulate human upper respiratory innate immunity. J Clin Invest 2014; 124: 1393-1405.
    • (2014) J Clin Invest , vol.124 , pp. 1393-1405
    • Lee, R.J.1    Kofonow, J.M.2    Rosen, P.L.3
  • 48
    • 78649735324 scopus 로고    scopus 로고
    • Airway mucus function and dysfunction
    • Fahy JV, Dickey BF. Airway mucus function and dysfunction. N Engl J Med 2010; 363: 2233-2247.
    • (2010) N Engl J Med , vol.363 , pp. 2233-2247
    • Fahy, J.V.1    Dickey, B.F.2
  • 49
    • 43549093774 scopus 로고    scopus 로고
    • Structure and function of the polymeric mucins in airways mucus
    • Thornton DJ, Rousseau K, McGuckin MA. Structure and function of the polymeric mucins in airways mucus. Annu Rev Physiol 2008; 70: 459-486.
    • (2008) Annu Rev Physiol , vol.70 , pp. 459-486
    • Thornton, D.J.1    Rousseau, K.2    McGuckin, M.A.3
  • 52
    • 84865305392 scopus 로고    scopus 로고
    • A periciliary brush promotes the lung health by separating the mucus layer from airway epithelia
    • Button B, Cai LH, Ehre C, et al. A periciliary brush promotes the lung health by separating the mucus layer from airway epithelia. Science 2012; 337: 937-941.
    • (2012) Science , vol.337 , pp. 937-941
    • Button, B.1    Cai, L.H.2    Ehre, C.3
  • 53
    • 77956240072 scopus 로고    scopus 로고
    • Airway surface liquid volume regulation determines different airway phenotypes in liddle compared with βENaC-overexpressing mice
    • Mall MA, Button B, Johannesson B, et al. Airway surface liquid volume regulation determines different airway phenotypes in liddle compared with βENaC-overexpressing mice. J Biol Chem 2010; 285: 26945-26955.
    • (2010) J Biol Chem , vol.285 , pp. 26945-26955
    • Mall, M.A.1    Button, B.2    Johannesson, B.3
  • 54
    • 84863476402 scopus 로고    scopus 로고
    • Reduced airway surface pH impairs bacterial killing in the porcine cystic fibrosis lung
    • Pezzulo AA, Tang XX, Hoegger MJ, et al. Reduced airway surface pH impairs bacterial killing in the porcine cystic fibrosis lung. Nature 2012; 487: 109-113.
    • (2012) Nature , vol.487 , pp. 109-113
    • Pezzulo, A.A.1    Tang, X.X.2    Hoegger, M.J.3
  • 55
    • 84906089250 scopus 로고    scopus 로고
    • Cystic fibrosis. Impaired mucus detachment disrupts mucociliary transport in a piglet model of cystic fibrosis
    • Hoegger MJ, Fischer AJ, McMenimen JD, et al. Cystic fibrosis. Impaired mucus detachment disrupts mucociliary transport in a piglet model of cystic fibrosis. Science 2014; 345: 818-822.
    • (2014) Science , vol.345 , pp. 818-822
    • Hoegger, M.J.1    Fischer, A.J.2    McMenimen, J.D.3
  • 56
    • 84896779634 scopus 로고    scopus 로고
    • Copy number variation of the β-defensin genes in Europeans: No supporting evidence for association with lung function, chronic obstructive pulmonary disease or asthma
    • Wain LV, Odenthal-Hesse L, Abujaber R, et al. Copy number variation of the β-defensin genes in Europeans: no supporting evidence for association with lung function, chronic obstructive pulmonary disease or asthma. PLoS One 2014; 9: e84192.
    • (2014) PLoS One , vol.9 , pp. e84192
    • Wain, L.V.1    Odenthal-Hesse, L.2    Abujaber, R.3
  • 57
    • 0036259798 scopus 로고    scopus 로고
    • β-Defensin 1 contributes to pulmonary innate immunity in mice
    • Moser C, Weiner DJ, Lysenko E, et al. β-Defensin 1 contributes to pulmonary innate immunity in mice. Infect Immun 2002; 70: 3068-3072.
    • (2002) Infect Immun , vol.70 , pp. 3068-3072
    • Moser, C.1    Weiner, D.J.2    Lysenko, E.3
  • 58
    • 0036259887 scopus 로고    scopus 로고
    • Characterization of the mouse β defensin 1, Defb1, mutant mouse model
    • Morrison G, Kilanowski F, Davidson D, et al. Characterization of the mouse β defensin 1, Defb1, mutant mouse model. Infect Immun 2002; 70: 3053-3060.
    • (2002) Infect Immun , vol.70 , pp. 3053-3060
    • Morrison, G.1    Kilanowski, F.2    Davidson, D.3
  • 59
    • 60549100921 scopus 로고    scopus 로고
    • Suppression of pulmonary innate host defence in smokers
    • Herr C, Beisswenger C, Hess C et al. Suppression of pulmonary innate host defence in smokers. Thorax 2009; 64: 144-149.
    • (2009) Thorax , vol.64 , pp. 144-149
    • Herr, C.1    Beisswenger, C.2    Hess, C.3
  • 60
    • 0032482980 scopus 로고    scopus 로고
    • The peptide antibiotic LL-37/hCAP-18 is expressed in epithelia of the human lung where it has broad antimicrobial activity at the airway surface
    • Bals R, Wang X, Zasloff M, et al. The peptide antibiotic LL-37/hCAP-18 is expressed in epithelia of the human lung where it has broad antimicrobial activity at the airway surface. Proc Natl Acad Sci USA 1998; 95: 9541-9546.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 9541-9546
    • Bals, R.1    Wang, X.2    Zasloff, M.3
  • 61
    • 84862899930 scopus 로고    scopus 로고
    • Cathelicidin-related antimicrobial peptide is required for effective lung mucosal immunity in Gram-negative bacterial pneumonia
    • Kovach MA, Ballinger MN, Newstead MW, et al. Cathelicidin-related antimicrobial peptide is required for effective lung mucosal immunity in Gram-negative bacterial pneumonia. J Immunol 2012; 189: 304-311.
    • (2012) J Immunol , vol.189 , pp. 304-311
    • Kovach, M.A.1    Ballinger, M.N.2    Newstead, M.W.3
  • 62
    • 84887412947 scopus 로고    scopus 로고
    • Little peptide, big effects: The role of LL-37 in inflammation and autoimmune disease
    • Kahlenberg JM, Kaplan MJ. Little peptide, big effects: the role of LL-37 in inflammation and autoimmune disease. J Immunol 2013; 191: 4895-4901.
    • (2013) J Immunol , vol.191 , pp. 4895-4901
    • Kahlenberg, J.M.1    Kaplan, M.J.2
  • 63
    • 33645224419 scopus 로고    scopus 로고
    • Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response
    • Liu PT, Stenger S, Li H, et al. Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science 2006; 311: 1770-1773.
    • (2006) Science , vol.311 , pp. 1770-1773
    • Liu, P.T.1    Stenger, S.2    Li, H.3
  • 64
    • 33750944535 scopus 로고    scopus 로고
    • The antimicrobial peptide cathelicidin interacts with airway mucus
    • Felgentreff K, Beisswenger C, Griese M, et al. The antimicrobial peptide cathelicidin interacts with airway mucus. Peptides 2006; 27: 3100-3106.
    • (2006) Peptides , vol.27 , pp. 3100-3106
    • Felgentreff, K.1    Beisswenger, C.2    Griese, M.3
  • 65
    • 1542287347 scopus 로고    scopus 로고
    • Neutrophil extracellular traps kill bacteria
    • Brinkmann V, Reichard U, Goosmann C, et al. Neutrophil extracellular traps kill bacteria. Science 2004; 303: 1532-1535.
    • (2004) Science , vol.303 , pp. 1532-1535
    • Brinkmann, V.1    Reichard, U.2    Goosmann, C.3
  • 66
    • 0037115169 scopus 로고    scopus 로고
    • Lactoperoxidase and hydrogen peroxide metabolism in the airway
    • Conner GE, Salathe M, Forteza R. Lactoperoxidase and hydrogen peroxide metabolism in the airway. Am J Respir Crit Care Med 2002; 166: S57-S61.
    • (2002) Am J Respir Crit Care Med , vol.166 , pp. S57-S61
    • Conner, G.E.1    Salathe, M.2    Forteza, R.3
  • 67
    • 33846314338 scopus 로고    scopus 로고
    • A novel host defense system of airways is defective in cystic fibrosis
    • Moskwa P, Lorentzen D, Excoffon KJ, et al. A novel host defense system of airways is defective in cystic fibrosis. Am J Respir Crit Care Med 2007; 175: 174-183.
    • (2007) Am J Respir Crit Care Med , vol.175 , pp. 174-183
    • Moskwa, P.1    Lorentzen, D.2    Excoffon, K.J.3
  • 68
    • 79957862375 scopus 로고    scopus 로고
    • Nitric oxide and redox mechanisms in the immune response
    • Wink DA, Hines HB, Cheng RY, et al. Nitric oxide and redox mechanisms in the immune response. J Leukoc Biol 2011; 89: 873-891.
    • (2011) J Leukoc Biol , vol.89 , pp. 873-891
    • Wink, D.A.1    Hines, H.B.2    Cheng, R.Y.3
  • 69
    • 78751489990 scopus 로고    scopus 로고
    • The airway epithelium: Soldier in the fight against respiratory viruses
    • Vareille M, Kieninger E, Edwards MR, et al. The airway epithelium: soldier in the fight against respiratory viruses. Clin Microbiol Rev 2011; 24: 210-229.
    • (2011) Clin Microbiol Rev , vol.24 , pp. 210-229
    • Vareille, M.1    Kieninger, E.2    Edwards, M.R.3
  • 70
    • 80051570241 scopus 로고    scopus 로고
    • Hypersusceptibility to respiratory viruses as a shared mechanism for asthma, chronic obstructive pulmonary disease, and cystic fibrosis
    • Holtzman M, Patel D, Kim HJ, et al. Hypersusceptibility to respiratory viruses as a shared mechanism for asthma, chronic obstructive pulmonary disease, and cystic fibrosis. Am J Respir Cell Mol Biol 2011; 44: 739-742.
    • (2011) Am J Respir Cell Mol Biol , vol.44 , pp. 739-742
    • Holtzman, M.1    Patel, D.2    Kim, H.J.3
  • 71
    • 84860526569 scopus 로고    scopus 로고
    • High throughput screening for small molecule enhancers of the interferon signaling pathway to drive next-generation antiviral drug discovery
    • Patel DA, Patel AC, Nolan WC, et al. High throughput screening for small molecule enhancers of the interferon signaling pathway to drive next-generation antiviral drug discovery. PLoS One 2012; 7: e36594.
    • (2012) PLoS One , vol.7 , pp. e36594
    • Patel, D.A.1    Patel, A.C.2    Nolan, W.C.3
  • 72
    • 0037728657 scopus 로고    scopus 로고
    • Impaired innate host defense causes susceptibility to respiratory virus infections in cystic fibrosis
    • Zheng S, De BP, Choudhary S, et al. Impaired innate host defense causes susceptibility to respiratory virus infections in cystic fibrosis. Immunity 2003; 18: 619-630.
    • (2003) Immunity , vol.18 , pp. 619-630
    • Zheng, S.1    De, B.P.2    Choudhary, S.3
  • 73
    • 77956404377 scopus 로고    scopus 로고
    • Eaten alive: A history of macroautophagy
    • Yang Z, Klionsky DJ. Eaten alive: a history of macroautophagy. Nat Cell Biol 2010; 12: 814-822.
    • (2010) Nat Cell Biol , vol.12 , pp. 814-822
    • Yang, Z.1    Klionsky, D.J.2
  • 74
    • 84896955758 scopus 로고    scopus 로고
    • "Ciliophagy": The consumption of cilia components by autophagy
    • Cloonan SM, Lam HC, Ryter SW, et al. "Ciliophagy": the consumption of cilia components by autophagy. Autophagy 2014; 10: 532-534.
    • (2014) Autophagy , vol.10 , pp. 532-534
    • Cloonan, S.M.1    Lam, H.C.2    Ryter, S.W.3
  • 75
    • 84920754266 scopus 로고    scopus 로고
    • Airway epithelial barrier function regulates the pathogenesis of allergic asthma
    • Heijink IH, Nawijn MC, Hackett TL. Airway epithelial barrier function regulates the pathogenesis of allergic asthma. Clin Exp Allergy 2014; 44: 620-630.
    • (2014) Clin Exp Allergy , vol.44 , pp. 620-630
    • Heijink, I.H.1    Nawijn, M.C.2    Hackett, T.L.3
  • 76
    • 84890294428 scopus 로고    scopus 로고
    • Epithelial injury and repair in airways diseases
    • Grainge CL, Davies DE. Epithelial injury and repair in airways diseases. Chest 2013; 144: 1906-1912.
    • (2013) Chest , vol.144 , pp. 1906-1912
    • Grainge, C.L.1    Davies, D.E.2
  • 77
    • 54949112835 scopus 로고    scopus 로고
    • TMEM16A, a membrane protein associated with calcium-dependent chloride channel activity
    • Caputo A, Caci E, Ferrera L, et al. TMEM16A, a membrane protein associated with calcium-dependent chloride channel activity. Science 2008; 322: 590-594.
    • (2008) Science , vol.322 , pp. 590-594
    • Caputo, A.1    Caci, E.2    Ferrera, L.3
  • 78
    • 84867181870 scopus 로고    scopus 로고
    • SLC26A9-mediated chloride secretion prevents mucus obstruction in airway inflammation
    • Anagnostopoulou P, Riederer B, Duerr J, et al. SLC26A9-mediated chloride secretion prevents mucus obstruction in airway inflammation. J Clin Invest 2012; 122: 3629-3634.
    • (2012) J Clin Invest , vol.122 , pp. 3629-3634
    • Anagnostopoulou, P.1    Riederer, B.2    Duerr, J.3
  • 80
    • 17144403499 scopus 로고    scopus 로고
    • Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus
    • Wark PA, Johnston SL, Bucchieri F, et al. Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus. J Exp Med 2005; 201: 937-947.
    • (2005) J Exp Med , vol.201 , pp. 937-947
    • Wark, P.A.1    Johnston, S.L.2    Bucchieri, F.3
  • 81
    • 33746210220 scopus 로고    scopus 로고
    • Allergic airway inflammation inhibits pulmonary antibacterial host defense
    • Beisswenger C, Kandler K, Hess C, et al. Allergic airway inflammation inhibits pulmonary antibacterial host defense. J Immunol 2006; 177: 1833-1837.
    • (2006) J Immunol , vol.177 , pp. 1833-1837
    • Beisswenger, C.1    Kandler, K.2    Hess, C.3
  • 82
    • 84883537459 scopus 로고    scopus 로고
    • Long-term IL-33-producing epithelial progenitor cells in chronic obstructive lung disease
    • Byers DE, Alexander-Brett J, Patel AC, et al. Long-term IL-33-producing epithelial progenitor cells in chronic obstructive lung disease. J Clin Invest 2013; 123: 3967-3982.
    • (2013) J Clin Invest , vol.123 , pp. 3967-3982
    • Byers, D.E.1    Alexander-Brett, J.2    Patel, A.C.3
  • 83
    • 79957512933 scopus 로고    scopus 로고
    • Effect of bronchoconstriction on airway remodeling in asthma
    • Grainge CL, Lau LC, Ward JA, et al. Effect of bronchoconstriction on airway remodeling in asthma. N Engl J Med 2011; 364: 2006-2015.
    • (2011) N Engl J Med , vol.364 , pp. 2006-2015
    • Grainge, C.L.1    Lau, L.C.2    Ward, J.A.3
  • 84
    • 0034130795 scopus 로고    scopus 로고
    • Transforming growth factor-β1 is a potent inhibitor of secretory leukoprotease inhibitor expression in a bronchial epithelial cell line
    • Munich Lung Transplant Group
    • Jaumann F, Elssner A, Mazur G, et al. Transforming growth factor-β1 is a potent inhibitor of secretory leukoprotease inhibitor expression in a bronchial epithelial cell line. Munich Lung Transplant Group. Eur Respir J 2000; 15: 1052-1057.
    • (2000) Eur Respir J , vol.15 , pp. 1052-1057
    • Jaumann, F.1    Elssner, A.2    Mazur, G.3
  • 85
    • 84866126983 scopus 로고    scopus 로고
    • Transforming growth factor-β promotes rhinovirus replication in bronchial epithelial cells by suppressing the innate immune response
    • Bedke N, Sammut D, Green B, et al. Transforming growth factor-β promotes rhinovirus replication in bronchial epithelial cells by suppressing the innate immune response. PLoS One 2012; 7: e44580.
    • (2012) PLoS One , vol.7 , pp. e44580
    • Bedke, N.1    Sammut, D.2    Green, B.3
  • 86
    • 84901797652 scopus 로고    scopus 로고
    • Cigarette smoke-induced disruption of bronchial epithelial tight junctions is prevented by transforming growth factor-β
    • Schamberger AC, Mise N, Jia J, et al. Cigarette smoke-induced disruption of bronchial epithelial tight junctions is prevented by transforming growth factor-β. Am J Respir Cell Mol Biol 2014; 50: 1040-1052.
    • (2014) Am J Respir Cell Mol Biol , vol.50 , pp. 1040-1052
    • Schamberger, A.C.1    Mise, N.2    Jia, J.3
  • 87
    • 0042847362 scopus 로고    scopus 로고
    • Transforming growth factor-β-Smad signaling pathway negatively regulates nontypeable Haemophilus influenzae-induced MUC5AC mucin transcription via mitogen-activated protein kinase (MAPK) phosphatase-1-dependent inhibition of p38 MAPK
    • Jono H, Xu H, Kai H, et al. Transforming growth factor-β-Smad signaling pathway negatively regulates nontypeable Haemophilus influenzae-induced MUC5AC mucin transcription via mitogen-activated protein kinase (MAPK) phosphatase-1-dependent inhibition of p38 MAPK. J Biol Chem 2003; 278: 27811-27819.
    • (2003) J Biol Chem , vol.278 , pp. 27811-27819
    • Jono, H.1    Xu, H.2    Kai, H.3
  • 88
    • 84872723771 scopus 로고    scopus 로고
    • 2 decreases baseline and IL-13-stimulated mucin production by primary human bronchial epithelial cells
    • 2 decreases baseline and IL-13-stimulated mucin production by primary human bronchial epithelial cells. Exp Lung Res 2013; 39: 39-47.
    • (2013) Exp Lung Res , vol.39 , pp. 39-47
    • Harrop, C.A.1    Gore, R.B.2    Evans, C.M.3
  • 89
    • 84863737591 scopus 로고    scopus 로고
    • Cigarette smoke modulates expression of human rhinovirus-induced airway epithelial host defense genes
    • Proud D, Hudy MH, Wiehler S, et al. Cigarette smoke modulates expression of human rhinovirus-induced airway epithelial host defense genes. PLoS One 2012; 7: e40762.
    • (2012) PLoS One , vol.7 , pp. e40762
    • Proud, D.1    Hudy, M.H.2    Wiehler, S.3
  • 90
    • 0033785188 scopus 로고    scopus 로고
    • Effect of cigarette smoke on the permeability and IL-1β and sICAM-1 release from cultured human bronchial epithelial cells of never-smokers, smokers, and patients with chronic obstructive pulmonary disease
    • Rusznak C, Mills PR, Devalia JL, et al. Effect of cigarette smoke on the permeability and IL-1β and sICAM-1 release from cultured human bronchial epithelial cells of never-smokers, smokers, and patients with chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol 2000; 23: 530-536.
    • (2000) Am J Respir Cell Mol Biol , vol.23 , pp. 530-536
    • Rusznak, C.1    Mills, P.R.2    Devalia, J.L.3
  • 91
    • 84856645410 scopus 로고    scopus 로고
    • Peptidylarginine deiminases present in the airways during tobacco smoking and inflammation can citrullinate the host defense peptide LL-37, resulting in altered activities
    • Kilsgard O, Andersson P, Malmsten M, et al. Peptidylarginine deiminases present in the airways during tobacco smoking and inflammation can citrullinate the host defense peptide LL-37, resulting in altered activities. Am J Respir Cell Mol Biol 2012; 46: 240-248.
    • (2012) Am J Respir Cell Mol Biol , vol.46 , pp. 240-248
    • Kilsgard, O.1    Andersson, P.2    Malmsten, M.3
  • 92
    • 84895538354 scopus 로고    scopus 로고
    • Molecular processes that drive cigarette smoke-induced epithelial cell fate of the lung
    • Nyunoya T, Mebratu Y, Contreras A, et al. Molecular processes that drive cigarette smoke-induced epithelial cell fate of the lung. Am J Respir Cell Mol Biol 2013; 50: 471-482.
    • (2013) Am J Respir Cell Mol Biol , vol.50 , pp. 471-482
    • Nyunoya, T.1    Mebratu, Y.2    Contreras, A.3
  • 93
    • 84877153384 scopus 로고    scopus 로고
    • A dynamic bronchial airway gene expression signature of chronic obstructive pulmonary disease and lung function impairment
    • Steiling K, van den Berge M, Hijazi K, et al. A dynamic bronchial airway gene expression signature of chronic obstructive pulmonary disease and lung function impairment. Am J Respir Crit Care Med 2013; 187: 933-942.
    • (2013) Am J Respir Crit Care Med , vol.187 , pp. 933-942
    • Steiling, K.1    Van Den Berge, M.2    Hijazi, K.3
  • 94
    • 84905655597 scopus 로고    scopus 로고
    • CFTR: Cystic fibrosis and beyond
    • Mall MA, Hartl D. CFTR: cystic fibrosis and beyond. Eur Respir J 2014; 44: 1042-1054.
    • (2014) Eur Respir J , vol.44 , pp. 1042-1054
    • Mall, M.A.1    Hartl, D.2
  • 95
    • 0042072794 scopus 로고    scopus 로고
    • Expression and release of interleukin-8 by human bronchial epithelial cells from patients with chronic obstructive pulmonary disease, smokers, and never-smokers
    • Schulz C, Wolf K, Harth M, et al. Expression and release of interleukin-8 by human bronchial epithelial cells from patients with chronic obstructive pulmonary disease, smokers, and never-smokers. Respiration 2003; 70: 254-261.
    • (2003) Respiration , vol.70 , pp. 254-261
    • Schulz, C.1    Wolf, K.2    Harth, M.3
  • 96
    • 84893023527 scopus 로고    scopus 로고
    • Increased ERK signalling promotes inflammatory signalling in primary airway epithelial cells expressing Z alpha1-antitrypsin
    • van't Wout EF, Dickens JA, van Schadewijk A, et al. Increased ERK signalling promotes inflammatory signalling in primary airway epithelial cells expressing Z alpha1-antitrypsin. Hum Mol Genet 2014; 23: 929-941.
    • (2014) Hum Mol Genet , vol.23 , pp. 929-941
    • Van'T Wout, E.F.1    Dickens, J.A.2    Van Schadewijk, A.3
  • 97
    • 52949154301 scopus 로고    scopus 로고
    • Disruption of the CFTR gene produces a model of cystic fibrosis in newborn pigs
    • Rogers CS, Stoltz DA, Meyerholz DK, et al. Disruption of the CFTR gene produces a model of cystic fibrosis in newborn pigs. Science 2008; 321: 1837-1841.
    • (2008) Science , vol.321 , pp. 1837-1841
    • Rogers, C.S.1    Stoltz, D.A.2    Meyerholz, D.K.3
  • 98
    • 79952779452 scopus 로고    scopus 로고
    • The ΔF508 mutation causes CFTR misprocessing and cystic fibrosis-like disease in pigs
    • Ostedgaard LS, Meyerholz DK, Chen JH, et al. The ΔF508 mutation causes CFTR misprocessing and cystic fibrosis-like disease in pigs. Sci Transl Med 2011; 3: 74ra24.
    • (2011) Sci Transl Med , vol.3 , pp. 74ra24
    • Ostedgaard, L.S.1    Meyerholz, D.K.2    Chen, J.H.3
  • 99
    • 41849102053 scopus 로고    scopus 로고
    • Adeno-associated virus-targeted disruption of the CFTR gene in cloned ferrets
    • Sun X, Yan Z, Yi Y, et al. Adeno-associated virus-targeted disruption of the CFTR gene in cloned ferrets. J Clin Invest 2008; 118: 1578-1583.
    • (2008) J Clin Invest , vol.118 , pp. 1578-1583
    • Sun, X.1    Yan, Z.2    Yi, Y.3
  • 100
    • 84897426911 scopus 로고    scopus 로고
    • Characterization of defects in ion transport and tissue development in cystic fibrosis transmembrane conductance regulator (CFTR)-knockout rats
    • Tuggle KL, Birket SE, Cui X, et al. Characterization of defects in ion transport and tissue development in cystic fibrosis transmembrane conductance regulator (CFTR)-knockout rats. PLoS One 2014; 9: e91253.
    • (2014) PLoS One , vol.9 , pp. e91253
    • Tuggle, K.L.1    Birket, S.E.2    Cui, X.3
  • 101
    • 77952974496 scopus 로고    scopus 로고
    • Cystic fibrosis pigs develop lung disease and exhibit defective bacterial eradication at birth
    • Stoltz DA, Meyerholz DK, Pezzulo AA, et al. Cystic fibrosis pigs develop lung disease and exhibit defective bacterial eradication at birth. Sci Transl Med 2010; 2: 29-31.
    • (2010) Sci Transl Med , vol.2 , pp. 29-31
    • Stoltz, D.A.1    Meyerholz, D.K.2    Pezzulo, A.A.3
  • 102
    • 77956379893 scopus 로고    scopus 로고
    • Disease phenotype of a ferret CFTR-knockout model of cystic fibrosis
    • Sun X, Sui H, Fisher JT, et al. Disease phenotype of a ferret CFTR-knockout model of cystic fibrosis. J Clin Invest 2010; 120: 3149-3160.
    • (2010) J Clin Invest , vol.120 , pp. 3149-3160
    • Sun, X.1    Sui, H.2    Fisher, J.T.3
  • 103
    • 84895512997 scopus 로고    scopus 로고
    • Lung phenotype of juvenile and adult cystic fibrosis transmembrane conductance regulator-knockout ferrets
    • Sun X, Olivier AK, Liang B, et al. Lung phenotype of juvenile and adult cystic fibrosis transmembrane conductance regulator-knockout ferrets. Am J Respir Cell Mol Biol 2014; 50: 502-512.
    • (2014) Am J Respir Cell Mol Biol , vol.50 , pp. 502-512
    • Sun, X.1    Olivier, A.K.2    Liang, B.3
  • 104
    • 0037252641 scopus 로고    scopus 로고
    • Airway surface pH in subjects with cystic fibrosis
    • McShane D, Davies JC, Davies MG, et al. Airway surface pH in subjects with cystic fibrosis. Eur Respir J 2003; 21: 37-42.
    • (2003) Eur Respir J , vol.21 , pp. 37-42
    • McShane, D.1    Davies, J.C.2    Davies, M.G.3
  • 105
    • 84902333159 scopus 로고    scopus 로고
    • Neonates with cystic fibrosis have a reduced nasal liquid pH: A small pilot study
    • Abou Alaiwa MH, Beer AM, Pezzulo AA, et al. Neonates with cystic fibrosis have a reduced nasal liquid pH: a small pilot study. J Cyst Fibros 2014; 13: 373-377.
    • (2014) J Cyst Fibros , vol.13 , pp. 373-377
    • Abou Alaiwa, M.H.1    Beer, A.M.2    Pezzulo, A.A.3
  • 106
    • 84901604661 scopus 로고    scopus 로고
    • Effects of airway surface liquid pH on host defense in cystic fibrosis
    • Berkebile AR, McCray PB Jr. Effects of airway surface liquid pH on host defense in cystic fibrosis. Int J Biochem Cell Biol 2014; 52: 124-129.
    • (2014) Int J Biochem Cell Biol , vol.52 , pp. 124-129
    • Berkebile, A.R.1    McCray, P.B.2
  • 107
    • 34047166052 scopus 로고    scopus 로고
    • Airway surface dehydration in cystic fibrosis: Pathogenesis and therapy
    • Boucher RC. Airway surface dehydration in cystic fibrosis: pathogenesis and therapy. Annu Rev Med 2007; 58: 157-170.
    • (2007) Annu Rev Med , vol.58 , pp. 157-170
    • Boucher, R.C.1
  • 108
    • 84884284486 scopus 로고    scopus 로고
    • Does epithelial sodium channel hyperactivity contribute to cystic fibrosis lung disease?
    • Hobbs CA, Da Tan C, Tarran R. Does epithelial sodium channel hyperactivity contribute to cystic fibrosis lung disease? J Physiol 2013; 591: 4377-4387.
    • (2013) J Physiol , vol.591 , pp. 4377-4387
    • Hobbs, C.A.1    Da Tan, C.2    Tarran, R.3
  • 109
    • 78649915334 scopus 로고    scopus 로고
    • Loss of anion transport without increased sodium absorption characterizes newborn porcine cystic fibrosis airway epithelia
    • Chen JH, Stoltz DA, Karp PH, et al. Loss of anion transport without increased sodium absorption characterizes newborn porcine cystic fibrosis airway epithelia. Cell 2010; 143: 911-923.
    • (2010) Cell , vol.143 , pp. 911-923
    • Chen, J.H.1    Stoltz, D.A.2    Karp, P.H.3
  • 110
    • 84887060074 scopus 로고    scopus 로고
    • Bioelectric characterization of epithelia from neonatal CFTR knockout ferrets
    • Fisher JT, Tyler SR, Zhang Y, et al. Bioelectric characterization of epithelia from neonatal CFTR knockout ferrets. Am J Respir Cell Mol Biol 2013; 49: 837-844.
    • (2013) Am J Respir Cell Mol Biol , vol.49 , pp. 837-844
    • Fisher, J.T.1    Tyler, S.R.2    Zhang, Y.3
  • 112
    • 2442718786 scopus 로고    scopus 로고
    • + absorption produces cystic fibrosis-like lung disease in mice
    • + absorption produces cystic fibrosis-like lung disease in mice. Nat Med 2004; 10: 487-493.
    • (2004) Nat Med , vol.10 , pp. 487-493
    • Mall, M.1    Grubb, B.R.2    Harkema, J.R.3
  • 113
    • 84903759350 scopus 로고    scopus 로고
    • Cystic fibrosis airway secretions exhibit mucin hyperconcentration and increased osmotic pressure
    • Henderson AG, Ehre C, Button B, et al. Cystic fibrosis airway secretions exhibit mucin hyperconcentration and increased osmotic pressure. J Clin Invest 2014; 124: 3047-3060.
    • (2014) J Clin Invest , vol.124 , pp. 3047-3060
    • Henderson, A.G.1    Ehre, C.2    Button, B.3
  • 114
    • 77949890696 scopus 로고    scopus 로고
    • miR-126 is downregulated in cystic fibrosis airway epithelial cells and regulates TOM1 expression
    • Oglesby IK, Bray IM, Chotirmall SH, et al. miR-126 is downregulated in cystic fibrosis airway epithelial cells and regulates TOM1 expression. J Immunol 2010; 184: 1702-1709.
    • (2010) J Immunol , vol.184 , pp. 1702-1709
    • Oglesby, I.K.1    Bray, I.M.2    Chotirmall, S.H.3
  • 115
    • 79960807167 scopus 로고    scopus 로고
    • MicroRNA regulation of expression of the cystic fibrosis transmembrane conductance regulator gene
    • Gillen AE, Gosalia N, Leir SH, et al. MicroRNA regulation of expression of the cystic fibrosis transmembrane conductance regulator gene. Biochem J 2011; 438: 25-32.
    • (2011) Biochem J , vol.438 , pp. 25-32
    • Gillen, A.E.1    Gosalia, N.2    Leir, S.H.3
  • 116
    • 80054777791 scopus 로고    scopus 로고
    • Synergistic post-transcriptional regulation of the cystic fibrosis transmembrane conductance regulator (CFTR) by miR-101 and miR-494 specific binding
    • Megiorni F, Cialfi S, Dominici C, et al. Synergistic post-transcriptional regulation of the cystic fibrosis transmembrane conductance regulator (CFTR) by miR-101 and miR-494 specific binding. PLoS One 2011; 6: e26601.
    • (2011) PLoS One , vol.6 , pp. e26601
    • Megiorni, F.1    Cialfi, S.2    Dominici, C.3
  • 117
    • 84886530607 scopus 로고    scopus 로고
    • Post-transcriptional regulation of cystic fibrosis transmembrane conductance regulator expression and function by microRNAs
    • Ramachandran S, Karp PH, Osterhaus SR, et al. Post-transcriptional regulation of cystic fibrosis transmembrane conductance regulator expression and function by microRNAs. Am J Respir Cell Mol Biol 2013; 49: 544-551.
    • (2013) Am J Respir Cell Mol Biol , vol.49 , pp. 544-551
    • Ramachandran, S.1    Karp, P.H.2    Osterhaus, S.R.3
  • 118
    • 84865176379 scopus 로고    scopus 로고
    • A microRNA network regulates expression and biosynthesis of wild-type and DeltaF508 mutant cystic fibrosis transmembrane conductance regulator
    • Ramachandran S, Karp PH, Jiang P, et al. A microRNA network regulates expression and biosynthesis of wild-type and DeltaF508 mutant cystic fibrosis transmembrane conductance regulator. Proc Natl Acad Sci USA 2012; 109: 13362-13367.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 13362-13367
    • Ramachandran, S.1    Karp, P.H.2    Jiang, P.3
  • 119
    • 84871247957 scopus 로고    scopus 로고
    • microRNAs in asthma: Potential therapeutic targets
    • Greene CM, Gaughan KP. microRNAs in asthma: potential therapeutic targets. Curr Opin Pulm Med 2013; 19: 66-72.
    • (2013) Curr Opin Pulm Med , vol.19 , pp. 66-72
    • Greene, C.M.1    Gaughan, K.P.2
  • 120
    • 84865434716 scopus 로고    scopus 로고
    • Developing microRNA therapeutics: Approaching the unique complexities
    • Jackson AL, Levin AA. Developing microRNA therapeutics: approaching the unique complexities. Nucleic Acid Ther 2012; 22: 213-225.
    • (2012) Nucleic Acid Ther , vol.22 , pp. 213-225
    • Jackson, A.L.1    Levin, A.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.