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Volumn 111, Issue 17, 2014, Pages

Generation of multiciliated cells in functional airway epithelia from human induced pluripotent stem cells

Author keywords

Bronchi; Definitive endoderm; Differentiation

Indexed keywords

CHEMOKINE RECEPTOR CXCR4; CYCLIC AMP; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; FORKHEAD TRANSCRIPTION FACTOR; HEPATOCYTE NUCLEAR FACTOR 3BETA; NOTCH RECEPTOR; PERICENTRIN; STEM CELL FACTOR RECEPTOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FORKHEAD BOX PROTEIN J1; TRANSCRIPTION FACTOR GATA 6; TRANSCRIPTION FACTOR SOX17; TUBULIN; UNCLASSIFIED DRUG;

EID: 84899644608     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1403470111     Document Type: Article
Times cited : (194)

References (65)
  • 1
    • 39149086020 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from fibroblast cultures
    • Takahashi K, Okita K, Nakagawa M, Yamanaka S (2007) Induction of pluripotent stem cells from fibroblast cultures. Nat Protoc 2(12):3081-3089.
    • (2007) Nat Protoc , vol.2 , Issue.12 , pp. 3081-3089
    • Takahashi, K.1    Okita, K.2    Nakagawa, M.3    Yamanaka, S.4
  • 2
    • 84866067664 scopus 로고    scopus 로고
    • Directed differentiation of human pluripotent stem cells into mature airway epithelia expressing functional CFTR protein
    • Wong AP, et al. (2012) Directed differentiation of human pluripotent stem cells into mature airway epithelia expressing functional CFTR protein. Nat Biotechnol 30(9): 876-882.
    • (2012) Nat Biotechnol , vol.30 , Issue.9 , pp. 876-882
    • Wong, A.P.1
  • 3
    • 84859555858 scopus 로고    scopus 로고
    • Directing lung endoderm differentiation in pluripotent stem cells
    • Kadzik RS, Morrisey EE (2012) Directing lung endoderm differentiation in pluripotent stem cells. Cell Stem Cell 10(4):355-361.
    • (2012) Cell Stem Cell , vol.10 , Issue.4 , pp. 355-361
    • Kadzik, R.S.1    Morrisey, E.E.2
  • 4
    • 33846834049 scopus 로고    scopus 로고
    • Transcriptional control of lung morphogenesis
    • Maeda Y, Davé V, Whitsett JA (2007) Transcriptional control of lung morphogenesis. Physiol Rev 87(1):219-244.
    • (2007) Physiol Rev , vol.87 , Issue.1 , pp. 219-244
    • Maeda, Y.1    Davé, V.2    Whitsett, J.A.3
  • 6
    • 0032857527 scopus 로고    scopus 로고
    • Bmp signaling regulates proximal-distal differentiation of endoderm in mouse lung development
    • WeaverM, Yingling JM, Dunn NR, Bellusci S, Hogan BL (1999) Bmp signaling regulates proximal-distal differentiation of endoderm in mouse lung development. Development 126(18):4005-4015.
    • (1999) Development , vol.126 , Issue.18 , pp. 4005-4015
    • Weaver, M.1    Yingling, J.M.2    Dunn, N.R.3    Bellusci, S.4    Hogan, B.L.5
  • 8
    • 35948971816 scopus 로고    scopus 로고
    • Key mechanisms of early lung development
    • Kimura J, Deutsch GH (2007) Key mechanisms of early lung development. Pediatr Dev Pathol 10(5):335-347.
    • (2007) Pediatr Dev Pathol , vol.10 , Issue.5 , pp. 335-347
    • Kimura, J.1    Deutsch, G.H.2
  • 9
    • 42649142250 scopus 로고    scopus 로고
    • Sox2 is important for two crucial processes in lung development: Branching morphogenesis and epithelial cell differentiation
    • Gontan C, et al. (2008) Sox2 is important for two crucial processes in lung development: Branching morphogenesis and epithelial cell differentiation. Dev Biol 317(1):296-309.
    • (2008) Dev Biol , vol.317 , Issue.1 , pp. 296-309
    • Gontan, C.1
  • 10
    • 28644448149 scopus 로고    scopus 로고
    • Efficient differentiation of human embryonic stem cells to definitive endoderm
    • D'Amour KA, et al. (2005) Efficient differentiation of human embryonic stem cells to definitive endoderm. Nat Biotechnol 23(12):1534-1541.
    • (2005) Nat Biotechnol , vol.23 , Issue.12 , pp. 1534-1541
    • D'Amour, K.A.1
  • 11
    • 77956383019 scopus 로고    scopus 로고
    • Recent advances and prospects in the differentiation of pancreatic cells from human embryonic stem cells
    • Mfopou JK, Chen B, Sui L, Sermon K, Bouwens L (2010) Recent advances and prospects in the differentiation of pancreatic cells from human embryonic stem cells. Diabetes 59(9):2094-2101.
    • (2010) Diabetes , vol.59 , Issue.9 , pp. 2094-2101
    • Mfopou, J.K.1    Chen, B.2    Sui, L.3    Sermon, K.4    Bouwens, L.5
  • 12
    • 79952397747 scopus 로고    scopus 로고
    • Generation of anterior foregut endoderm from human embryonic and induced pluripotent stem cells
    • Green MD, et al. (2011) Generation of anterior foregut endoderm from human embryonic and induced pluripotent stem cells. Nat Biotechnol 29(3):267-272.
    • (2011) Nat Biotechnol , vol.29 , Issue.3 , pp. 267-272
    • Green, M.D.1
  • 13
    • 8644242325 scopus 로고    scopus 로고
    • FGF-10 induces SP-C and Bmp4 and regulates proximal-distal patterning in embryonic tracheal epithelium
    • Hyatt BA, Shangguan X, Shannon JM (2004) FGF-10 induces SP-C and Bmp4 and regulates proximal-distal patterning in embryonic tracheal epithelium. Am J Physiol Lung Cell Mol Physiol 287(6):L1116-L1126.
    • (2004) Am J Physiol Lung Cell Mol Physiol , vol.287 , Issue.6
    • Hyatt, B.A.1    Shangguan, X.2    Shannon, J.M.3
  • 14
    • 14244257104 scopus 로고    scopus 로고
    • Identification of FGF10 targets in the embryonic lung epithelium during bud morphogenesis
    • Lü J, Izvolsky KI, Qian J, Cardoso WV (2005) Identification of FGF10 targets in the embryonic lung epithelium during bud morphogenesis. J Biol Chem 280(6):4834-4841.
    • (2005) J Biol Chem , vol.280 , Issue.6 , pp. 4834-4841
    • Lü, J.1    Izvolsky, K.I.2    Qian, J.3    Cardoso, W.V.4
  • 15
    • 0031457616 scopus 로고    scopus 로고
    • Fibroblast growth factor 10 (FGF10) and branching morphogenesis in the embryonic mouse lung
    • Bellusci S, Grindley J, Emoto H, Itoh N, Hogan BL (1997) Fibroblast growth factor 10 (FGF10) and branching morphogenesis in the embryonic mouse lung. Development 124(23):4867-4878.
    • (1997) Development , vol.124 , Issue.23 , pp. 4867-4878
    • Bellusci, S.1    Grindley, J.2    Emoto, H.3    Itoh, N.4    Hogan, B.L.5
  • 16
    • 0032803573 scopus 로고    scopus 로고
    • Fibroblast growth factor interactions in the developing lung
    • Lebeche D, Malpel S, Cardoso WV (1999) Fibroblast growth factor interactions in the developing lung. Mech Dev 86(1-2):125-136.
    • (1999) Mech Dev , vol.86 , Issue.1-2 , pp. 125-136
    • Lebeche, D.1    Malpel, S.2    Cardoso, W.V.3
  • 17
    • 0030236278 scopus 로고    scopus 로고
    • Keratinocyte growth factor and embryonic rat lung morphogenesis
    • Shiratori M, et al. (1996) Keratinocyte growth factor and embryonic rat lung morphogenesis. Am J Respir Cell Mol Biol 15(3):328-338.
    • (1996) Am J Respir Cell Mol Biol , vol.15 , Issue.3 , pp. 328-338
    • Shiratori, M.1
  • 18
    • 79955561301 scopus 로고    scopus 로고
    • Follistatin-like 1 (Fstl1) is a bone morphogenetic protein (BMP) 4 signaling antagonist in controlling mouse lung development
    • Geng Y, et al. (2011) Follistatin-like 1 (Fstl1) is a bone morphogenetic protein (BMP) 4 signaling antagonist in controlling mouse lung development. Proc Natl Acad Sci USA 108(17):7058-7063.
    • (2011) Proc Natl Acad Sci USA , vol.108 , Issue.17 , pp. 7058-7063
    • Geng, Y.1
  • 19
    • 0442323558 scopus 로고    scopus 로고
    • NKX2. 1 regulates transcription of the gene for human bone morphogenetic protein-4 in lung epithelial cells
    • Zhu NL, Li C, Xiao J, Minoo P (2004) NKX2.1 regulates transcription of the gene for human bone morphogenetic protein-4 in lung epithelial cells. Gene 327(1):25-36.
    • (2004) Gene , vol.327 , Issue.1 , pp. 25-36
    • Zhu, N.L.1    Li, C.2    Xiao, J.3    Minoo, P.4
  • 20
    • 84881072034 scopus 로고    scopus 로고
    • Pax8 has a critical role in epithelial cell survival and proliferation
    • Di Palma T, et al. (2013) Pax8 has a critical role in epithelial cell survival and proliferation. Cell Death Dis 4:e729.
    • (2013) Cell Death Dis , vol.4
    • Di Palma, T.1
  • 21
    • 82455175320 scopus 로고    scopus 로고
    • Gene expression profiling at early organogenesis reveals both common and diverse mechanisms in foregut patterning
    • Fagman H, et al. (2011) Gene expression profiling at early organogenesis reveals both common and diverse mechanisms in foregut patterning. Dev Biol 359(2):163-175.
    • (2011) Dev Biol , vol.359 , Issue.2 , pp. 163-175
    • Fagman, H.1
  • 22
    • 0028385690 scopus 로고
    • Ciliogenesis in human bronchial epithelial cells cultured at the air-liquid interface
    • de Jong PM, et al. (1994) Ciliogenesis in human bronchial epithelial cells cultured at the air-liquid interface. Am J Respir Cell Mol Biol 10(3):271-277.
    • (1994) Am J Respir Cell Mol Biol , vol.10 , Issue.3 , pp. 271-277
    • De Jong, P.M.1
  • 23
    • 33644512890 scopus 로고    scopus 로고
    • A three-dimensional model of differentiation of immortalized human bronchial epithelial cells
    • Vaughan MB, Ramirez RD, Wright WE, Minna JD, Shay JW (2006) A three-dimensional model of differentiation of immortalized human bronchial epithelial cells. Differentiation 74(4):141-148.
    • (2006) Differentiation , vol.74 , Issue.4 , pp. 141-148
    • Vaughan, M.B.1    Ramirez, R.D.2    Wright, W.E.3    Minna, J.D.4    Shay, J.W.5
  • 24
    • 79957797173 scopus 로고    scopus 로고
    • Notch-dependent differentiation of adult airway basal stem cells
    • Rock JR, et al. (2011) Notch-dependent differentiation of adult airway basal stem cells. Cell Stem Cell 8(6):639-648.
    • (2011) Cell Stem Cell , vol.8 , Issue.6 , pp. 639-648
    • Rock, J.R.1
  • 25
    • 33746442106 scopus 로고    scopus 로고
    • Radial intercalation of ciliated cells during Xenopus skin development
    • Stubbs JL, Davidson L, Keller R, Kintner C (2006) Radial intercalation of ciliated cells during Xenopus skin development. Development 133(13):2507-2515.
    • (2006) Development , vol.133 , Issue.13 , pp. 2507-2515
    • Stubbs, J.L.1    Davidson, L.2    Keller, R.3    Kintner, C.4
  • 26
    • 79960782549 scopus 로고    scopus 로고
    • Notch signaling prevents mucous metaplasia in mouse conducting airways during postnatal development
    • Tsao PN, et al. (2011) Notch signaling prevents mucous metaplasia in mouse conducting airways during postnatal development. Development 138(16):3533-3543.
    • (2011) Development , vol.138 , Issue.16 , pp. 3533-3543
    • Tsao, P.N.1
  • 27
    • 84856460296 scopus 로고    scopus 로고
    • Multicilin promotes centriole assembly and ciliogenesis during multiciliate cell differentiation
    • Stubbs JL, Vladar EK, Axelrod JD, Kintner C (2012) Multicilin promotes centriole assembly and ciliogenesis during multiciliate cell differentiation. Nat Cell Biol 14(2):140-147.
    • (2012) Nat Cell Biol , vol.14 , Issue.2 , pp. 140-147
    • Stubbs, J.L.1    Vladar, E.K.2    Axelrod, J.D.3    Kintner, C.4
  • 28
    • 80052412073 scopus 로고    scopus 로고
    • MicroRNA-based silencing of Delta/Notch signaling promotes multiple cilia formation
    • Marcet B, Chevalier B, Coraux C, Kodjabachian L, Barbry P (2011) MicroRNA-based silencing of Delta/Notch signaling promotes multiple cilia formation. Cell Cycle 10(17): 2858-2864.
    • (2011) Cell Cycle , vol.10 , Issue.17 , pp. 2858-2864
    • Marcet, B.1    Chevalier, B.2    Coraux, C.3    Kodjabachian, L.4    Barbry, P.5
  • 29
    • 84876310954 scopus 로고    scopus 로고
    • Rer1p maintains ciliary length and signaling by regulating γ-secretase activity and Foxj1a levels
    • Jurisch-Yaksi N, et al. (2013) Rer1p maintains ciliary length and signaling by regulating γ-secretase activity and Foxj1a levels. J Cell Biol 200(6):709-720.
    • (2013) J Cell Biol , vol.200 , Issue.6 , pp. 709-720
    • Jurisch-Yaksi, N.1
  • 30
    • 68549121214 scopus 로고    scopus 로고
    • Notch signaling promotes airway mucous metaplasia and inhibits alveolar development
    • Guseh JS, et al. (2009) Notch signaling promotes airway mucous metaplasia and inhibits alveolar development. Development 136(10):1751-1759.
    • (2009) Development , vol.136 , Issue.10 , pp. 1751-1759
    • Guseh, J.S.1
  • 31
    • 84892149549 scopus 로고    scopus 로고
    • Efficient generation of lung and airway epithelial cells from human pluripotent stem cells
    • Huang SX, et al. (2014) Efficient generation of lung and airway epithelial cells from human pluripotent stem cells. Nat Biotechnol 32(1):84-91.
    • (2014) Nat Biotechnol , vol.32 , Issue.1 , pp. 84-91
    • Huang, S.X.1
  • 32
    • 84859551885 scopus 로고    scopus 로고
    • Efficient derivation of purified lung and thyroid progenitors from embryonic stem cells
    • Longmire TA, et al. (2012) Efficient derivation of purified lung and thyroid progenitors from embryonic stem cells. Cell Stem Cell 10(4):398-411.
    • (2012) Cell Stem Cell , vol.10 , Issue.4 , pp. 398-411
    • Longmire, T.A.1
  • 33
    • 0141497319 scopus 로고    scopus 로고
    • C/EBP transcription factors in the lung epithelium
    • Cassel TN, Nord M (2003) C/EBP transcription factors in the lung epithelium. Am J Physiol Lung Cell Mol Physiol 285(4):L773-L781.
    • (2003) Am J Physiol Lung Cell Mol Physiol , vol.285 , Issue.4
    • Cassel, T.N.1    Nord, M.2
  • 34
    • 84859770990 scopus 로고    scopus 로고
    • Airway epithelial cell differentiation during lung organogenesis requires C/EBPα and C/EBPβ
    • Roos AB, Berg T, Barton JL, Didon L, Nord M (2012) Airway epithelial cell differentiation during lung organogenesis requires C/EBPα and C/EBPβ. Dev Dyn 241(5): 911-923.
    • (2012) Dev Dyn , vol.241 , Issue.5 , pp. 911-923
    • Roos, A.B.1    Berg, T.2    Barton, J.L.3    Didon, L.4    Nord, M.5
  • 35
  • 36
    • 0026636673 scopus 로고
    • Differentiated structure and function of cultures from human tracheal epithelium
    • Yamaya M, Finkbeiner WE, Chun SY, Widdicombe JH (1992) Differentiated structure and function of cultures from human tracheal epithelium. Am J Physiol 262(6 Pt 1): L713-L724.
    • (1992) Am J Physiol , vol.262 , Issue.6 PART 1
    • Yamaya, M.1    Finkbeiner, W.E.2    Chun, S.Y.3    Widdicombe, J.H.4
  • 37
    • 80052327898 scopus 로고    scopus 로고
    • Use of primary cultures of human bronchial epithelial cells isolated from cystic fibrosis patients for the pre-clinical testing of CFTR modulators
    • Neuberger T, Burton B, Clark H, Van Goor F (2011) Use of primary cultures of human bronchial epithelial cells isolated from cystic fibrosis patients for the pre-clinical testing of CFTR modulators. Methods Mol Biol 741:39-54.
    • (2011) Methods Mol Biol , vol.741 , pp. 39-54
    • Neuberger, T.1    Burton, B.2    Clark, H.3    Van Goor, F.4
  • 39
    • 79961095619 scopus 로고    scopus 로고
    • Mucociliary interactions and mucus dynamics in ciliated human bronchial epithelial cell cultures
    • Sears PR, Davis CW, Chua M, Sheehan JK (2011) Mucociliary interactions and mucus dynamics in ciliated human bronchial epithelial cell cultures. Am J Physiol Lung Cell Mol Physiol 301(2):L181-L186.
    • (2011) Am J Physiol Lung Cell Mol Physiol , vol.301 , Issue.2
    • Sears, P.R.1    Davis, C.W.2    Chua, M.3    Sheehan, J.K.4
  • 40
    • 0032530370 scopus 로고    scopus 로고
    • Coordinated clearance of periciliary liquid and mucus from airway surfaces
    • Matsui H, Randell SH, Peretti SW, Davis CW, Boucher RC (1998) Coordinated clearance of periciliary liquid and mucus from airway surfaces. J Clin Invest 102(6):1125-1131.
    • (1998) J Clin Invest , vol.102 , Issue.6 , pp. 1125-1131
    • Matsui, H.1    Randell, S.H.2    Peretti, S.W.3    Davis, C.W.4    Boucher, R.C.5
  • 41
    • 2342417378 scopus 로고    scopus 로고
    • Foxj1 regulates basal body anchoring to the cytoskeleton of ciliated pulmonary epithelial cells
    • Gomperts BN, Gong-Cooper X, Hackett BP (2004) Foxj1 regulates basal body anchoring to the cytoskeleton of ciliated pulmonary epithelial cells. J Cell Sci 117(Pt 8): 1329-1337.
    • (2004) J Cell Sci , vol.117 , Issue.PART 8 , pp. 1329-1337
    • Gomperts, B.N.1    Gong-Cooper, X.2    Hackett, B.P.3
  • 42
    • 56749152216 scopus 로고    scopus 로고
    • The forkhead protein Foxj1 specifies node-like cilia in Xenopus and zebrafish embryos
    • Stubbs JL, Oishi I, Izpisúa Belmonte JC, Kintner C (2008) The forkhead protein Foxj1 specifies node-like cilia in Xenopus and zebrafish embryos. Nat Genet 40(12):1454-1460.
    • (2008) Nat Genet , vol.40 , Issue.12 , pp. 1454-1460
    • Stubbs, J.L.1    Oishi, I.2    Izpisúa Belmonte, J.C.3    Kintner, C.4
  • 43
    • 4444320182 scopus 로고    scopus 로고
    • Pericentrin forms a complex with intraflagellar transport proteins and polycystin-2 and is required for primary cilia assembly
    • Jurczyk A, et al. (2004) Pericentrin forms a complex with intraflagellar transport proteins and polycystin-2 and is required for primary cilia assembly. J Cell Biol 166(5): 637-643.
    • (2004) J Cell Biol , vol.166 , Issue.5 , pp. 637-643
    • Jurczyk, A.1
  • 44
    • 77956858214 scopus 로고    scopus 로고
    • Temporal relationship between primary and motile ciliogenesis in airway epithelial cells
    • Jain R, et al. (2010) Temporal relationship between primary and motile ciliogenesis in airway epithelial cells. Am J Respir Cell Mol Biol 43(6):731-739.
    • (2010) Am J Respir Cell Mol Biol , vol.43 , Issue.6 , pp. 731-739
    • Jain, R.1
  • 45
    • 69549088763 scopus 로고    scopus 로고
    • Notch signaling controls the balance of ciliated and secretory cell fates in developing airways
    • Tsao PN, et al. (2009) Notch signaling controls the balance of ciliated and secretory cell fates in developing airways. Development 136(13):2297-2307.
    • (2009) Development , vol.136 , Issue.13 , pp. 2297-2307
    • Tsao, P.N.1
  • 46
    • 0032965275 scopus 로고    scopus 로고
    • Number and proliferation of clara cells in normal human airway epithelium
    • Boers JE, Ambergen AW, Thunnissen FB (1999) Number and proliferation of clara cells in normal human airway epithelium. Am J Respir Crit Care Med 159(5 Pt 1):1585-1591.
    • (1999) Am J Respir Crit Care Med , vol.159 , Issue.5 PART 1 , pp. 1585-1591
    • Boers, J.E.1    Ambergen, A.W.2    Thunnissen, F.B.3
  • 47
    • 0027956153 scopus 로고
    • Airway goblet cells: Responsive and adaptable front-line defenders
    • Rogers DF (1994) Airway goblet cells: Responsive and adaptable front-line defenders. Eur Respir J 7(9):1690-1706.
    • (1994) Eur Respir J , vol.7 , Issue.9 , pp. 1690-1706
    • Rogers, D.F.1
  • 48
    • 33644620356 scopus 로고    scopus 로고
    • Respiratory tract mucin genes and mucin glycoproteins in health and disease
    • Rose MC, Voynow JA (2006) Respiratory tract mucin genes and mucin glycoproteins in health and disease. Physiol Rev 86(1):245-278.
    • (2006) Physiol Rev , vol.86 , Issue.1 , pp. 245-278
    • Rose, M.C.1    Voynow, J.A.2
  • 49
    • 0031203730 scopus 로고    scopus 로고
    • Clara cells and Clara cell 10 kD protein (CC10)
    • Singh G, Katyal SL (1997) Clara cells and Clara cell 10 kD protein (CC10). Am J Respir Cell Mol Biol 17(2):141-143.
    • (1997) Am J Respir Cell Mol Biol , vol.17 , Issue.2 , pp. 141-143
    • Singh, G.1    Katyal, S.L.2
  • 50
    • 70349664159 scopus 로고    scopus 로고
    • SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production
    • Chen G, et al. (2009) SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production. J Clin Invest 119(10):2914-2924.
    • (2009) J Clin Invest , vol.119 , Issue.10 , pp. 2914-2924
    • Chen, G.1
  • 51
    • 77955549192 scopus 로고    scopus 로고
    • Pulmonary surfactant pathophysiology: Current models and open questions
    • Perez-Gil J, Weaver TE (2010) Pulmonary surfactant pathophysiology: Current models and open questions. Physiology (Bethesda) 25(3):132-141.
    • (2010) Physiology (Bethesda) , vol.25 , Issue.3 , pp. 132-141
    • Perez-Gil, J.1    Weaver, T.E.2
  • 52
    • 0026870883 scopus 로고
    • Surfactant protein C is expressed in alveolar type II cells but not in Clara cells of rat lung
    • Kalina M, Mason RJ, Shannon JM (1992) Surfactant protein C is expressed in alveolar type II cells but not in Clara cells of rat lung. Am J Respir Cell Mol Biol 6(6):594-600.
    • (1992) Am J Respir Cell Mol Biol , vol.6 , Issue.6 , pp. 594-600
    • Kalina, M.1    Mason, R.J.2    Shannon, J.M.3
  • 53
    • 0026646154 scopus 로고
    • Immunocytochemical localization of surfactant protein D (SP-D) in type II cells, Clara cells, and alveolar macrophages of rat lung
    • Voorhout WF, et al. (1992) Immunocytochemical localization of surfactant protein D (SP-D) in type II cells, Clara cells, and alveolar macrophages of rat lung. J Histochem Cytochem 40(10):1589-1597.
    • (1992) J Histochem Cytochem , vol.40 , Issue.10 , pp. 1589-1597
    • Voorhout, W.F.1
  • 54
    • 78650657069 scopus 로고    scopus 로고
    • Regulation of endogenous ENaC functional expression by CFTR and δf508-CFTR in airway epithelial cells
    • Rubenstein RC, et al. (2011) Regulation of endogenous ENaC functional expression by CFTR and δF508-CFTR in airway epithelial cells. Am J Physiol Lung Cell Mol Physiol 300(1):L88-L101.
    • (2011) Am J Physiol Lung Cell Mol Physiol , vol.300 , Issue.1
    • Rubenstein, R.C.1
  • 55
    • 84859557287 scopus 로고    scopus 로고
    • Generation of multipotent lung and airway progenitors from mouse ESCs and patient-specific cystic fibrosis iPSCs
    • Mou H, et al. (2012) Generation of multipotent lung and airway progenitors from mouse ESCs and patient-specific cystic fibrosis iPSCs. Cell Stem Cell 10(4):385-397.
    • (2012) Cell Stem Cell , vol.10 , Issue.4 , pp. 385-397
    • Mou, H.1
  • 56
    • 58149345565 scopus 로고    scopus 로고
    • Basal bodies platforms for building cilia
    • Marshall WF (2008) Basal bodies platforms for building cilia. Curr Top Dev Biol 85:1-22.
    • (2008) Curr Top Dev Biol , vol.85 , pp. 1-22
    • Marshall, W.F.1
  • 57
    • 0442313529 scopus 로고    scopus 로고
    • Primary ciliary dyskinesia: Diagnostic and phenotypic features
    • Noone PG, et al. (2004) Primary ciliary dyskinesia: Diagnostic and phenotypic features. Am J Respir Crit Care Med 169(4):459-467.
    • (2004) Am J Respir Crit Care Med , vol.169 , Issue.4 , pp. 459-467
    • Noone, P.G.1
  • 58
    • 73849134811 scopus 로고    scopus 로고
    • Canonical Notch signaling in the developing lung is required for determination of arterial smooth muscle cells and selection of Clara versus ciliated cell fate
    • Morimoto M, et al. (2010) Canonical Notch signaling in the developing lung is required for determination of arterial smooth muscle cells and selection of Clara versus ciliated cell fate. J Cell Sci 123(Pt 2):213-224.
    • (2010) J Cell Sci , vol.123 , Issue.PART 2 , pp. 213-224
    • Morimoto, M.1
  • 59
    • 34447545501 scopus 로고    scopus 로고
    • Distribution of Clara cell secretory protein expression in the tracheobronchial airways of rhesus monkeys
    • Coppens JT, Van Winkle LS, Pinkerton K, Plopper CG (2007) Distribution of Clara cell secretory protein expression in the tracheobronchial airways of rhesus monkeys. Am J Physiol Lung Cell Mol Physiol 292(5):L1155-L1162.
    • (2007) Am J Physiol Lung Cell Mol Physiol , vol.292 , Issue.5
    • Coppens, J.T.1    Van Winkle, L.S.2    Pinkerton, K.3    Plopper, C.G.4
  • 60
    • 0029841922 scopus 로고    scopus 로고
    • Different mucins are produced by the surface epithelium and the submucosa in human trachea: Identification of MUC5AC as a major mucin from the goblet cells
    • Hovenberg HW, Davies JR, Carlstedt I (1996) Different mucins are produced by the surface epithelium and the submucosa in human trachea: Identification of MUC5AC as a major mucin from the goblet cells. Biochem J 318(Pt 1):319-324.
    • (1996) Biochem J , vol.318 , Issue.PART 1 , pp. 319-324
    • Hovenberg, H.W.1    Davies, J.R.2    Carlstedt, I.3
  • 61
    • 33845543076 scopus 로고    scopus 로고
    • The mouse trap: It still yields few answers in asthma
    • discussion 1176-1178
    • Wenzel S, Holgate ST (2006) The mouse trap: It still yields few answers in asthma. Am J Respir Crit Care Med 174(11):1173-1176, discussion 1176-1178.
    • (2006) Am J Respir Crit Care Med , vol.174 , Issue.11 , pp. 1173-1176
    • Wenzel, S.1    Holgate, S.T.2
  • 62
    • 77956379893 scopus 로고    scopus 로고
    • Disease phenotype of a ferret CFTR-knockout model of cystic fibrosis
    • Sun X, et al. (2010) Disease phenotype of a ferret CFTR-knockout model of cystic fibrosis. J Clin Invest 120(9):3149-3160.
    • (2010) J Clin Invest , vol.120 , Issue.9 , pp. 3149-3160
    • Sun, X.1
  • 63
    • 0034605705 scopus 로고    scopus 로고
    • Characterization of the Calu-3 cell line as a tool to screen pulmonary drug delivery
    • Foster KA, Avery ML, Yazdanian M, Audus KL (2000) Characterization of the Calu-3 cell line as a tool to screen pulmonary drug delivery. Int J Pharm 208(1-2):1-11.
    • (2000) Int J Pharm , vol.208 , Issue.1-2 , pp. 1-11
    • Foster, K.A.1    Avery, M.L.2    Yazdanian, M.3    Audus, K.L.4
  • 64
    • 84866317436 scopus 로고    scopus 로고
    • Evaluation of differentiated human bronchial epithelial cell culture systems for asthma research
    • Stewart CE, Torr EE, Mohd Jamili NH, Bosquillon C, Sayers I (2012) Evaluation of differentiated human bronchial epithelial cell culture systems for asthma research. J Allergy (Cairo) 2012:943982.
    • (2012) J Allergy (Cairo) , vol.2012 , pp. 943982
    • Stewart, C.E.1    Torr, E.E.2    Mohd Jamili, N.H.3    Bosquillon, C.4    Sayers, I.5
  • 65
    • 79960558872 scopus 로고    scopus 로고
    • Targeted genome editing across species using ZFNs and TALENs
    • Wood AJ, et al. (2011) Targeted genome editing across species using ZFNs and TALENs. Science 333(6040):307.
    • (2011) Science , vol.333 , Issue.6040 , pp. 307
    • Wood, A.J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.