Dectin-1 is inducible and plays a crucial role in Aspergillus-induced innate immune responses in human bronchial epithelial cells

European Journal of Clinical Microbiology and Infectious Diseases

Volumn 31, Issue 10, 2012, Pages 2755-2764

  Sun, W K ^a   Lu, X ^b   Li, X ^b   Sun, Q Y ^b   Su, X ^a   Song, Y ^a   Sun, H M ^a   Shi, Y ^a  

^a JINLING HOSPITAL   (China)

^b NANJING UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; DECTIN 1; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 8; MESSENGER RNA; POLYPEPTIDE ANTIBIOTIC AGENT; PROTEIN HBD2; PROTEIN HBD9; REACTIVE OXYGEN METABOLITE; TOLL LIKE RECEPTOR 2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; ASPERGILLUS FUMIGATUS; BRONCHUS MUCOSA; CELL CULTURE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITHELIUM CELL; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE MICROSCOPY; INNATE IMMUNITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; UPREGULATION; WESTERN BLOTTING;

ASPERGILLOSIS; ASPERGILLUS FUMIGATUS; BETA-DEFENSINS; BRONCHI; BRONCHIAL PROVOCATION TESTS; CELL LINE, TUMOR; EPITHELIAL CELLS; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; HUMANS; IMMUNITY, INNATE; INTERLEUKIN-8; LECTINS, C-TYPE; MICROSCOPY, FLUORESCENCE; POLYSACCHARIDES; REACTIVE OXYGEN SPECIES; RNA, MESSENGER; SPORES, FUNGAL; TIME FACTORS; TOLL-LIKE RECEPTOR 2; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84869125263     PISSN: 09349723     EISSN: 14354373     Source Type: Journal    
DOI: 10.1007/s10096-012-1624-8     Document Type: Article

References (40)

1. Denning DW, Anderson MJ, Turner G, Latgé JP, Bennett JW (2002) Sequencing the Aspergillus fumigatus genome. Lancet Infect Dis 2:251-253
2. Kleinberg M (2005) Aspergillosis in the CLEAR outcomes trial: working toward a real-world clinical perspective. Med Mycol 43 (Suppl 1):S289-S294
3. Romani L (2011) Immunity to fungal infections. Nat Rev Immunol 11:275-288
4. Walsh TJ, Roilides E, Cortez K, Kottilil S, Bailey J, Lyman CA (2005) Control, immunoregulation, and expression of innate pulmonary host defenses against Aspergillus fumigatus. Med Mycol 43(Suppl 1):S165-S172
5. Bellanger AP, Millon L, Khoufache K, Rivollet D, Bièche I, Laurendeau I et al (2009) Aspergillus fumigatus germ tube growth and not conidia ingestion induces expression of inflammatory mediator genes in the human lung epithelial cell line A549. J Med Microbiol 58:174-179
6. Zhang Z, Liu R, Noordhoek JA, Kauffman HF (2005) Interaction of airway epithelial cells (A549) with spores and mycelium of Aspergillus fumigatus. J Infect 51:375-382
7. Tai HY, Tam MF, Chou H, Peng HJ, Su SN, Perng DWet al (2006) Pen ch 13 allergen induces secretion of mediators and degradation of occludin protein of human lung epithelial cells. Allergy 61:382-388
8. Alekseeva L, Huet D, Féménia F, Mouyna I, Abdelouahab M, Cagna A et al (2009) Inducible expression of beta defensins by human respiratory epithelial cells exposed to Aspergillus fumigatus organisms. BMC Microbiol 9:33
9. Lee HM, Yuk JM, Shin DM, Jo EK (2009) Dectin-1 is inducible and plays an essential role for mycobacteria-induced innate immune responses in airway epithelial cells. J Clin Immunol 29:795-805
10. Lee HM, Shin DM, Choi DK, Lee ZW, Kim KH, Yuk JM et al (2009) Innate immune responses to Mycobacterium ulcerans via toll-like receptors and dectin-1 in human keratinocytes. CellMicrobiol 11:678-692
11. Schorey JS, Lawrence C (2008) The pattern recognition receptor Dectin-1: from fungi to mycobacteria. Curr Drug Targets 9:123-129
12. Reid DM, Montoya M, Taylor PR, Borrow P, Gordon S, Brown GD et al (2004) Expression of the beta-glucan receptor, Dectin-1, on murine leukocytes in situ correlates with its function in pathogen recognition and reveals potential roles in leukocyte interactions. J Leukoc Biol 76:86-94
13. Taylor PR, Tsoni SV, Willment JA, Dennehy KM, Rosas M, Findon H et al (2007) Dectin-1 is required for beta-glucan recognition and control of fungal infection. Nat Immunol 8:31-38
14. Underhill DM (2007) Collaboration between the innate immune receptors dectin-1, TLRs, and Nods. Immunol Rev 219:75-87
15. Xing Z, Harper R, Anunciacion J, Yang Z, Gao W, Qu B et al (2011) Host immune and apoptotic responses to avian influenza virus H9N2 in human tracheobronchial epithelial cells. Am J Respir Cell Mol Biol 44:24-33
16. Hohl TM, Van Epps HL, Rivera A,Morgan LA, Chen PL, Feldmesser M et al (2005) Aspergillus fumigatus triggers inflammatory responses by stage-specific beta-glucan display. PLoS Pathog 1:e30
17. Mezger M, Kneitz S, Wozniok I, Kurzai O, Einsele H, Loeffler J (2008) Proinflammatory response of immature human dendritic cells is mediated by dectin-1 after exposure to Aspergillus fumigatus germ tubes. J Infect Dis 197:924-931
18. Xing Z, Conway EM, Kang C, Winoto A (2004) Essential role of survivin, an inhibitor of apoptosis protein, in T cell development, maturation, and homeostasis. J Exp Med 199:69-80
19. Xing Z, Cardona CJ, Adams S, Yang Z, Li J, Perez D et al (2009) Differential regulation of antiviral and proinflammatory cytokines and suppression of Fas-mediated apoptosis by NS1 of H9N2 avian influenza virus in chicken macrophages. J Gen Virol 90:1109-1118
20. Ye J, Li J, Yu Y, Wei Q, Deng W, Yu L (2010) L-carnitine attenuates oxidant injury in HK-2 cells via ROS-mitochondria pathway. Regul Pept 161:58-66
21. Blundell J, Blaiss CA, Etherton MR, Espinosa F, Tabuchi K,Walz C et al (2010) Neuroligin-1 deletion results in impaired spatial memory and increased repetitive behavior. J Neurosci 30:2115-2129
22. Balloy V, Sallenave JM, Wu Y, Touqui L, Latgé JP, Si-Tahar M et al (2008) Aspergillus fumigatus-induced interleukin-8 synthesis by respiratory epithelial cells is controlled by the phosphatidylinositol 3-kinase, p38 MAPK, and ERK1/2 pathways and not by the toll-like receptor-MyD88 pathway. J Biol Chem 283:30513-30521
23. Huttunen K, Hyvärinen A, Nevalainen A, Komulainen H, Hirvonen MR (2003) Production of proinflammatory mediators by indoor air bacteria and fungal spores in mouse and human cell lines. Environ Health Perspect 111:85-92
24. Borger P, Koëter GH, Timmerman JA, Vellenga E, Tomee JF, Kauffman HF (1999) Proteases from Aspergillus fumigatus induce interleukin (IL)-6 and IL-8 production in airway epithelial cell lines by transcriptional mechanisms. J Infect Dis 180:1267-1274
25. Gantner BN, Simmons RM, Underhill DM(2005) Dectin-1 mediates macrophage recognition of Candida albicans yeast but not filaments. EMBO J 24:1277-1286
26. Gribar SC, Richardson WM, Sodhi CP, Hackam DJ (2008) No longer an innocent bystander: epithelial toll-like receptor signaling in the development of mucosal inflammation. Mol Med 14:645-659
27. Herre J, Willment JA, Gordon S, Brown GD (2004) The role of Dectin-1 in antifungal immunity. Crit Rev Immunol 24:193-203
28. Brown GD, Gordon S (2001) Immune recognition. A new receptor for beta-glucans. Nature 413:36-37
29. Brown GD, Herre J, Williams DL, Willment JA, Marshall AS, Gordon S (2003) Dectin-1 mediates the biological effects of betaglucans. J Exp Med 197:1119-1124
30. Ariizumi K, Shen GL, Shikano S, Xu S, Ritter R 3rd, Kumamoto Tet al (2000) Identification of a novel, dendritic cell-Associatedmolecule, dectin-1, by subtractive cDNA cloning. J Biol Chem 275:20157-20167
31. Taylor PR, Brown GD, Reid DM, Willment JA, Martinez-Pomares L, Gordon S et al (2002) The beta-glucan receptor, dectin-1, is predominantly expressed on the surface of cells of the monocyte/macrophage and neutrophil lineages. J Immunol 169:3876-3882
32. Cunha C, Di Ianni M, Bozza S, Giovannini G, Zagarella S, Zelante T et al (2010) Dectin-1 Y238X polymorphism associates with susceptibility to invasive aspergillosis in hematopoietic transplantation through impairment of both recipient-And donordependent mechanisms of antifungal immunity. Blood 116:5394-5402
33. Dagenais TR,KellerNP (2009) Pathogenesis of Aspergillus fumigatus in invasive Aspergillosis. Clin Microbiol Rev 22:447-465
34. Dagenais TR, Giles SS, Aimanianda V, Latgé JP, Hull CM, Keller NP (2010) Aspergillus fumigatus LaeA-mediated phagocytosis is associated with a decreased hydrophobin layer. Infect Immun 78:823-829
35. Paris S, Debeaupuis JP, Crameri R, Carey M, Charlès F, Prévost MC et al (2003) Conidial hydrophobins of Aspergillus fumigatus. Appl Environ Microbiol 69:1581-1588
36. Akira S, Takeda K (2004) Toll-like receptor signalling. Nat Rev Immunol 4:499-511
37. Han X, Yu R, Zhen D, Tao S, Schmidt M, Han L (2011) Beta-1, 3-Glucan-induced host phospholipase D activation is involved in Aspergillus fumigatus internalization into type II human pneumocyte A549 cells. PLoS One 6:e21468
38. Nathan C (2006) Neutrophils and immunity: challenges and opportunities. Nat Rev Immunol 6:173-182
39. Segal BH, Romani LR (2009) Invasive aspergillosis in chronic granulomatous disease. Med Mycol 47(Suppl 1):S282-S290
40. Shin DM, Yang CS, Yuk JM, Lee JY, Kim KH, Shin SJ et al (2008) Mycobacterium abscessus activates the macrophage innate immune response via a physical and functional interaction between TLR2 and dectin-1. Cell Microbiol 10:1608-1621