메뉴 건너뛰기




Volumn 381, Issue 9869, 2013, Pages 861-873

Microbes and mucosal immune responses in asthma

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN; ALPHA TOCOPHEROL; INTERLEUKIN 25; INTERLEUKIN 33; MONOCLONAL ANTIBODY; PATTERN RECOGNITION RECEPTOR; VITAMIN D; ZINC;

EID: 84874733216     PISSN: 01406736     EISSN: 1474547X     Source Type: Journal    
DOI: 10.1016/S0140-6736(12)62202-8     Document Type: Review
Times cited : (137)

References (141)
  • 1
    • 33746294223 scopus 로고    scopus 로고
    • The global burden of asthma
    • Brahman SS. The global burden of asthma. Chest 2006; 130 (suppl 1): 4S-12S.
    • (2006) Chest , vol.130 , Issue.SUPPL. 1
    • Brahman, S.S.1
  • 3
    • 34548619942 scopus 로고    scopus 로고
    • Atopic sensitization and the international variation of asthma symptom prevalence in children
    • Weinmayr G, Weiland SK, Björkstén B, et al. Atopic sensitization and the international variation of asthma symptom prevalence in children. Am J Respir Crit Care Med 2007; 176: 565-74.
    • (2007) Am J Respir Crit Care Med , vol.176 , pp. 565-574
    • Weinmayr, G.1    Weiland, S.K.2    Björkstén, B.3
  • 4
    • 0037136537 scopus 로고    scopus 로고
    • The effect of infections on susceptibility to autoimmune and allergic diseases
    • Bach JF. The effect of infections on susceptibility to autoimmune and allergic diseases. N Engl J Med 2002; 347: 911-20.
    • (2002) N Engl J Med , vol.347 , pp. 911-920
    • Bach, J.F.1
  • 5
    • 84874750412 scopus 로고    scopus 로고
    • Global Initiative For Asthma (GINA): Global Strategy For Asthma Management And Prevention. Updated Dec 2012 accessed Jan 4, 2013
    • Global Initiative for Asthma (GINA): Global Strategy for Asthma Management and Prevention. Updated Dec, 2012. http://www. ginasthma.com (accessed Jan 4, 2013).
  • 6
    • 84860698476 scopus 로고    scopus 로고
    • Therapies for allergic inflammation: Refining strategies to induce tolerance
    • Akdis CA. Therapies for allergic inflammation: refining strategies to induce tolerance. Nat Med 2012; 18: 736-49.
    • (2012) Nat Med , vol.18 , pp. 736-749
    • Akdis, C.A.1
  • 7
    • 83155173902 scopus 로고    scopus 로고
    • Genetic and genomic approaches to asthma: New insights for the origins
    • Zhang Y, Moffatt MF, Cookson WO. Genetic and genomic approaches to asthma: new insights for the origins. Curr Opin Pulm Med 2012; 18: 6-13.
    • (2012) Curr Opin Pulm Med , vol.18 , pp. 6-13
    • Zhang, Y.1    Moffatt, M.F.2    Cookson, W.O.3
  • 8
    • 77957113600 scopus 로고    scopus 로고
    • A large-scale, consortium-based genomewide association study of asthma
    • Moffatt MF, Gut IG, Demenais F, et al. A large-scale, consortium-based genomewide association study of asthma. N Engl J Med 2010; 363: 1211-21.
    • (2010) N Engl J Med , vol.363 , pp. 1211-1221
    • Moffatt, M.F.1    Gut, I.G.2    Demenais, F.3
  • 10
    • 52049092296 scopus 로고    scopus 로고
    • Early identification of atopy in the prediction of persistent asthma in children
    • Sly PD, Boner AL, Bjorksten B, et al. Early identification of atopy in the prediction of persistent asthma in children. Lancet 2008; 372: 1100-06.
    • (2008) Lancet , vol.372 , pp. 1100-1106
    • Sly, P.D.1    Boner, A.L.2    Bjorksten, B.3
  • 11
    • 77749270570 scopus 로고    scopus 로고
    • Asthma and allergy: The early beginnings
    • Hawrylowicz C, Ryanna K. Asthma and allergy: the early beginnings. Nat Med 2010; 16: 274-75.
    • (2010) Nat Med , vol.16 , pp. 274-275
    • Hawrylowicz, C.1    Ryanna, K.2
  • 12
    • 84860666096 scopus 로고    scopus 로고
    • Viral infections and atopy in asthma pathogenesis: New rationales for asthma prevention and treatment
    • Holt PG, Sly PD. Viral infections and atopy in asthma pathogenesis: new rationales for asthma prevention and treatment. Nat Med 2012; 18: 726-35.
    • (2012) Nat Med , vol.18 , pp. 726-735
    • Holt, P.G.1    Sly, P.D.2
  • 15
    • 84875068215 scopus 로고    scopus 로고
    • Viral and bacterial interactions in the upper respiratory tract
    • Bosch AATM, Biesbroek G, Trzcinski K, Sanders EAM, Bogaert D. Viral and bacterial interactions in the upper respiratory tract. PLoS Pathog 2013; 9: 1-12.
    • (2013) PLoS Pathog , vol.9 , pp. 1-12
    • Aatm, B.1    Biesbroek, G.2    Trzcinski, K.3    Eam, S.4    Bogaert, D.5
  • 16
    • 77950350422 scopus 로고    scopus 로고
    • Asthma and allergic inflammation
    • Locksley RM. Asthma and allergic inflammation. Cell 2010; 140: 777-83.
    • (2010) Cell , vol.140 , pp. 777-783
    • Locksley, R.M.1
  • 19
    • 84862754513 scopus 로고    scopus 로고
    • Combined Haemophilus influenzae respiratory infection and allergic airways disease drives chronic infection and features of neutrophilic asthma
    • Essilfie AT, Simpson JL, Dunkley ML, et al. Combined Haemophilus influenzae respiratory infection and allergic airways disease drives chronic infection and features of neutrophilic asthma. Thorax 2012; 67: 588-99.
    • (2012) Thorax , vol.67 , pp. 588-599
    • Essilfie, A.T.1    Simpson, J.L.2    Dunkley, M.L.3
  • 20
    • 84860216630 scopus 로고    scopus 로고
    • Microbial exposure during early life has persistent effects on natural killer T cell function
    • Olszak T, An D, Zeissig S, et al. Microbial exposure during early life has persistent effects on natural killer T cell function. Science 2012; 336: 489-93.
    • (2012) Science , vol.336 , pp. 489-493
    • Olszak, T.1    An, D.2    Zeissig, S.3
  • 21
    • 84862276328 scopus 로고    scopus 로고
    • Structure function and diversity of the healthy human microbiome
    • Human Microbiome Project Consortium
    • Human Microbiome Project Consortium. Structure, function and diversity of the healthy human microbiome. Nature 2012; 486: 207-14.
    • (2012) Nature , vol.486 , pp. 207-214
  • 22
    • 84866167497 scopus 로고    scopus 로고
    • Reciprocal interactions of the intestinal microbiota and immune system
    • Maynard CL, Elson CO, Hatton RD, Weaver CT. Reciprocal interactions of the intestinal microbiota and immune system. Nature 2012; 489: 231-41.
    • (2012) Nature , vol.489 , pp. 231-241
    • Maynard, C.L.1    Elson, C.O.2    Hatton, R.D.3    Weaver, C.T.4
  • 23
    • 84861978076 scopus 로고    scopus 로고
    • Host-gut microbiota metabolic interactions
    • Nicholson JK, Holmes E, Kinross J, et al. Host-gut microbiota metabolic interactions. Science 2012; 336: 1262-67.
    • (2012) Science , vol.336 , pp. 1262-1267
    • Nicholson, J.K.1    Holmes, E.2    Kinross, J.3
  • 24
    • 84862800379 scopus 로고    scopus 로고
    • Significance of the microbiome in obstructive lung disease
    • Han MK, Huang YJ, Lipuma JJ, et al. Significance of the microbiome in obstructive lung disease. Thorax 2012; 67: 456-63.
    • (2012) Thorax , vol.67 , pp. 456-463
    • Han, M.K.1    Huang, Y.J.2    Lipuma, J.J.3
  • 25
    • 79551495183 scopus 로고    scopus 로고
    • Airway microbiota and bronchial hyperresponsiveness in patients with suboptimally controlled asthma
    • Huang YJ, Nelson CE, Brodie EL, et al. Airway microbiota and bronchial hyperresponsiveness in patients with suboptimally controlled asthma. J Allergy Clin Immunol 2011; 127: 372-81.
    • (2011) J Allergy Clin Immunol , vol.127 , pp. 372-381
    • Huang, Y.J.1    Nelson, C.E.2    Brodie, E.L.3
  • 26
    • 79955606197 scopus 로고    scopus 로고
    • Influence of gastrointestinal commensal bacteria on the immune responses that mediate allergy and asthma
    • McLoughlin RM, Mills KH. Influence of gastrointestinal commensal bacteria on the immune responses that mediate allergy and asthma. J Allergy Clin Immunol 2011; 127: 1097-107.
    • (2011) J Allergy Clin Immunol , vol.127 , pp. 1097-1107
    • McLoughlin, R.M.1    Mills, K.H.2
  • 27
    • 80052272960 scopus 로고    scopus 로고
    • Reduced diversity of the intestinal microbiota during infancy is associated with increased risk of allergic disease at school age
    • Bisgaard H, Li N, Bonnelykke K, et al. Reduced diversity of the intestinal microbiota during infancy is associated with increased risk of allergic disease at school age. J Allergy Clin Immunol 2011; 128: 646-52.
    • (2011) J Allergy Clin Immunol , vol.128 , pp. 646-652
    • Bisgaard, H.1    Li, N.2    Bonnelykke, K.3
  • 28
    • 77649323279 scopus 로고    scopus 로고
    • Lactobacillus casei abundance is associated with profound shifts in the infant gut microbiome
    • Cox MJ, Huang YJ, Fujimura KE, et al. Lactobacillus casei abundance is associated with profound shifts in the infant gut microbiome. PLoS One 2010; 5: e8745.
    • (2010) PLoS One , vol.5
    • Cox, M.J.1    Huang, Y.J.2    Fujimura, K.E.3
  • 29
    • 77649119443 scopus 로고    scopus 로고
    • Disordered microbial communities in asthmatic airways
    • Hilty M, Burke C, Pedro H, et al. Disordered microbial communities in asthmatic airways. PLoS ONE 2010; 5: e8578.
    • (2010) PLoS ONE , vol.5
    • Hilty, M.1    Burke, C.2    Pedro, H.3
  • 30
    • 79955627107 scopus 로고    scopus 로고
    • Gut microbiota, probiotics, and vitamin D: Interrelated exposures influencing allergy, asthma, and obesity?
    • Ly NP, Litonjua A, Gold DR, Celedon JC. Gut microbiota, probiotics, and vitamin D: interrelated exposures influencing allergy, asthma, and obesity? J Allergy Clin Immunol 2011; 127: 1087-94.
    • (2011) J Allergy Clin Immunol , vol.127 , pp. 1087-1094
    • Ly, N.P.1    Litonjua, A.2    Gold, D.R.3    Celedon, J.C.4
  • 31
    • 84865557344 scopus 로고    scopus 로고
    • Long-term macrolide treatment of chronic inflammatory airway diseases: Risks, benefits and future developments
    • Cameron EJ, McSharry C, Chaudhuri R, Farrow S, Thomson NC. Long-term macrolide treatment of chronic inflammatory airway diseases: risks, benefits and future developments. Clin Exp Allergy 2012; 42: 1302-12.
    • (2012) Clin Exp Allergy , vol.42 , pp. 1302-1312
    • Cameron, E.J.1    McSharry, C.2    Chaudhuri, R.3    Farrow, S.4    Thomson, N.C.5
  • 32
    • 77956354206 scopus 로고    scopus 로고
    • Role of viral respiratory infections in asthma and asthma exacerbations
    • Busse WW, Lemanske RF Jr, Gern JE. Role of viral respiratory infections in asthma and asthma exacerbations. Lancet 2010; 376: 826-34.
    • (2010) Lancet , vol.376 , pp. 826-834
    • Busse, W.W.1    Lemanske Jr., R.F.2    Gern, J.E.3
  • 34
    • 84864742968 scopus 로고    scopus 로고
    • Asthma as a chronic disease of the innate and adaptive immune systems responding to viruses and allergens
    • Holtzman MJ. Asthma as a chronic disease of the innate and adaptive immune systems responding to viruses and allergens. J Clin Invest 2012; 122: 2741-48.
    • (2012) J Clin Invest , vol.122 , pp. 2741-2748
    • Holtzman, M.J.1
  • 35
    • 77951885851 scopus 로고    scopus 로고
    • Structured regulation of inflammation during respiratory viral infection
    • Hussell T, Goulding J. Structured regulation of inflammation during respiratory viral infection. Lancet Infect Dis 2010; 10: 360-66.
    • (2010) Lancet Infect Dis , vol.10 , pp. 360-366
    • Hussell, T.1    Goulding, J.2
  • 37
    • 59749095702 scopus 로고    scopus 로고
    • The burden of respiratory syncytial virus infection in young children
    • Hall CB, Weinberg GA, Iwane MK, et al. The burden of respiratory syncytial virus infection in young children. N Engl J Med 2009; 360: 588-98.
    • (2009) N Engl J Med , vol.360 , pp. 588-598
    • Hall, C.B.1    Weinberg, G.A.2    Iwane, M.K.3
  • 38
    • 77951653074 scopus 로고    scopus 로고
    • Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: A systematic review and meta-analysis
    • Nair H, Nokes DJ, Gessner BD, et al. Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis. Lancet 2010; 375: 1545-55.
    • (2010) Lancet , vol.375 , pp. 1545-1555
    • Nair, H.1    Nokes, D.J.2    Gessner, B.D.3
  • 39
    • 84866373869 scopus 로고    scopus 로고
    • The impact of differential antiviral immunity in children and adults
    • Prendergast AJ, Klenerman P, Goulder PJ. The impact of differential antiviral immunity in children and adults. Nat Rev Immunol 2012; 12: 636-48.
    • (2012) Nat Rev Immunol , vol.12 , pp. 636-648
    • Prendergast, A.J.1    Klenerman, P.2    Goulder, P.J.3
  • 40
    • 84862883755 scopus 로고    scopus 로고
    • Determinants of asthma after severe respiratory syncytial virus bronchiolitis
    • Bacharier LB, Cohen R, Schweiger T, et al. Determinants of asthma after severe respiratory syncytial virus bronchiolitis. J Allergy Clin Immunol 2012; 130: 91-100.
    • (2012) J Allergy Clin Immunol , vol.130 , pp. 91-100
    • Bacharier, L.B.1    Cohen, R.2    Schweiger, T.3
  • 41
    • 77958471150 scopus 로고    scopus 로고
    • Asthma and allergy patterns over 18 years after severe RSV bronchiolitis in the first year of life
    • Sigurs N, Aljassim F, Kjellman B, et al. Asthma and allergy patterns over 18 years after severe RSV bronchiolitis in the first year of life. Thorax 2010; 65: 1045-52.
    • (2010) Thorax , vol.65 , pp. 1045-1052
    • Sigurs, N.1    Aljassim, F.2    Kjellman, B.3
  • 42
    • 84860288300 scopus 로고    scopus 로고
    • Respiratory syncytial virus infection in adult populations
    • Walsh EE, Falsey AR. Respiratory syncytial virus infection in adult populations. Infect Disord Drug Targets 2012; 12: 98-102.
    • (2012) Infect Disord Drug Targets , vol.12 , pp. 98-102
    • Walsh, E.E.1    Falsey, A.R.2
  • 43
    • 84870063516 scopus 로고    scopus 로고
    • Benefit and harm from immunity to respiratory syncytial virus: Implications for treatment
    • Habibi MS, Openshaw PJ. Benefit and harm from immunity to respiratory syncytial virus: implications for treatment. Curr Opin Infect Dis 2012; 25: 687-94.
    • (2012) Curr Opin Infect Dis , vol.25 , pp. 687-694
    • Habibi, M.S.1    Openshaw, P.J.2
  • 44
    • 80052422367 scopus 로고    scopus 로고
    • Respiratory syncytial virus load, viral dynamics, and disease severity in previously healthy naturally infected children
    • El Saleeby CM, Bush AJ, Harrison LM, Aitken JA, DeVincenzo JP. Respiratory syncytial virus load, viral dynamics, and disease severity in previously healthy naturally infected children. J Infect Dis 2011; 204: 996-1002.
    • (2011) J Infect Dis , vol.204 , pp. 996-1002
    • El Saleeby, C.M.1    Bush, A.J.2    Harrison, L.M.3    Aitken, J.A.4    Devincenzo, J.P.5
  • 45
    • 84869101988 scopus 로고    scopus 로고
    • Thymic stromal lymphopoietin is induced by respiratory syncytial virus-infected airway epithelial cells and promotes a type 2 response to infection
    • Lee HC, Headley MB, Loo YM, et al. Thymic stromal lymphopoietin is induced by respiratory syncytial virus-infected airway epithelial cells and promotes a type 2 response to infection. J Allergy Clin Immunol 2012; 130: 1187-96.
    • (2012) J Allergy Clin Immunol , vol.130 , pp. 1187-1196
    • Lee, H.C.1    Headley, M.B.2    Loo, Y.M.3
  • 46
    • 79960139777 scopus 로고    scopus 로고
    • Respiratory syncytial virus binds and undergoes transcription in neutrophils from the blood and airways of infants with severe bronchiolitis
    • Halfhide CP, Flanagan BF, Brearey SP, et al. Respiratory syncytial virus binds and undergoes transcription in neutrophils from the blood and airways of infants with severe bronchiolitis. J Infect Dis 2011; 204: 451-58.
    • (2011) J Infect Dis , vol.204 , pp. 451-458
    • Halfhide, C.P.1    Flanagan, B.F.2    Brearey, S.P.3
  • 47
    • 67349125447 scopus 로고    scopus 로고
    • Respiratory viruses and eosinophils: Exploring the connections
    • Rosenberg HF, Dyer KD, Domachowske JB. Respiratory viruses and eosinophils: exploring the connections. Antiviral Res 2009; 83: 1-9.
    • (2009) Antiviral Res , vol.83 , pp. 1-9
    • Rosenberg, H.F.1    Dyer, K.D.2    Domachowske, J.B.3
  • 48
    • 78650566298 scopus 로고    scopus 로고
    • Biological challenges and technological opportunities for respiratory syncytial virus vaccine development
    • Graham BS. Biological challenges and technological opportunities for respiratory syncytial virus vaccine development. Immunol Rev 2011; 239: 149-66.
    • (2011) Immunol Rev , vol.239 , pp. 149-166
    • Graham, B.S.1
  • 49
    • 33746858063 scopus 로고    scopus 로고
    • A potential molecular mechanism for hypersensitivity caused by formalin-inactivated vaccines
    • Moghaddam A, Olszewska W, Wang B, et al. A potential molecular mechanism for hypersensitivity caused by formalin-inactivated vaccines. Nat Med 2006; 12: 905-07.
    • (2006) Nat Med , vol.12 , pp. 905-907
    • Moghaddam, A.1    Olszewska, W.2    Wang, B.3
  • 50
    • 84860343998 scopus 로고    scopus 로고
    • Antibodies for prevention and treatment of respiratory syncytial virus infections in children
    • Geevarghese B, Simoes EA. Antibodies for prevention and treatment of respiratory syncytial virus infections in children. Antivir Ther 2012; 17 (1 pt B): 201-11.
    • (2012) Antivir Ther , vol.17 , Issue.1 PART B , pp. 201-211
    • Geevarghese, B.1    Simoes, E.A.2
  • 51
    • 64249159586 scopus 로고    scopus 로고
    • Sequencing and analyses of all known human rhinovirus genomes reveal structure and evolution
    • Palmenberg AC, Spiro D, Kuzmickas R, et al. Sequencing and analyses of all known human rhinovirus genomes reveal structure and evolution. Science 2009; 324: 55-59.
    • (2009) Science , vol.324 , pp. 55-59
    • Palmenberg, A.C.1    Spiro, D.2    Kuzmickas, R.3
  • 52
    • 24644436145 scopus 로고    scopus 로고
    • Rhinovirus illnesses during infancy predict subsequent childhood wheezing
    • Lemanske RF Jr, Jackson DJ, Gangnon RE, et al. Rhinovirus illnesses during infancy predict subsequent childhood wheezing. J Allergy Clin Immunol 2005; 116: 571-77.
    • (2005) J Allergy Clin Immunol , vol.116 , pp. 571-577
    • Lemanske Jr., R.F.1    Jackson, D.J.2    Gangnon, R.E.3
  • 53
    • 0036570265 scopus 로고    scopus 로고
    • Association of rhinovirus infection with increased disease severity in acute bronchiolitis
    • Papadopoulos NG, Moustaki M, Tsolia M, et al. Association of rhinovirus infection with increased disease severity in acute bronchiolitis. Am J Respir Crit Care Med 2002; 165: 1285-89.
    • (2002) Am J Respir Crit Care Med , vol.165 , pp. 1285-1289
    • Papadopoulos, N.G.1    Moustaki, M.2    Tsolia, M.3
  • 54
    • 52749097374 scopus 로고    scopus 로고
    • Wheezing rhinovirus illnesses in early life predict asthma development in high-risk children
    • Jackson DJ, Gangnon RE, Evans MD, et al. Wheezing rhinovirus illnesses in early life predict asthma development in high-risk children. Am J Respir Crit Care Med 2008; 178: 667-72.
    • (2008) Am J Respir Crit Care Med , vol.178 , pp. 667-672
    • Jackson, D.J.1    Gangnon, R.E.2    Evans, M.D.3
  • 55
    • 58849112561 scopus 로고    scopus 로고
    • Rhinovirus and the initiation of asthma
    • Gern JE. Rhinovirus and the initiation of asthma. Curr Opin Allergy Clin Immunol 2009; 9: 73-78.
    • (2009) Curr Opin Allergy Clin Immunol , vol.9 , pp. 73-78
    • Gern, J.E.1
  • 56
    • 34247500952 scopus 로고    scopus 로고
    • Early-life respiratory viral infections, atopic sensitization, and risk of subsequent development of persistent asthma
    • Kusel MM, de Klerk NH, Kebadze T, et al. Early-life respiratory viral infections, atopic sensitization, and risk of subsequent development of persistent asthma. J Allergy Clin Immunol 2007; 119: 1105-10.
    • (2007) J Allergy Clin Immunol , vol.119 , pp. 1105-1110
    • Kusel, M.M.1    De Klerk, N.H.2    Kebadze, T.3
  • 58
    • 0037045846 scopus 로고    scopus 로고
    • Frequency, severity, and duration of rhinovirus infections in asthmatic and non-asthmatic individuals: A longitudinal cohort study
    • Corne JM, Marshall C, Smith S, et al. Frequency, severity, and duration of rhinovirus infections in asthmatic and non-asthmatic individuals: a longitudinal cohort study. Lancet 2002; 359: 831-34.
    • (2002) Lancet , vol.359 , pp. 831-834
    • Corne, J.M.1    Marshall, C.2    Smith, S.3
  • 59
    • 50249181160 scopus 로고    scopus 로고
    • Deficient interferon in virus-induced asthma exacerbations
    • Edwards MR, Johnston SL. Deficient interferon in virus-induced asthma exacerbations. Clin Exp Allergy 2008; 38: 1416-18.
    • (2008) Clin Exp Allergy , vol.38 , pp. 1416-1418
    • Edwards, M.R.1    Johnston, S.L.2
  • 60
    • 51649109114 scopus 로고    scopus 로고
    • Rhinovirus-induced lower respiratory illness is increased in asthma and related to virus load and Th1/2 cytokine and IL-10 production
    • Message SD, Laza-Stanca V, Mallia P, et al. Rhinovirus-induced lower respiratory illness is increased in asthma and related to virus load and Th1/2 cytokine and IL-10 production. Proc Natl Acad Sci USA 2008; 105: 13562-67.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 13562-13567
    • Message, S.D.1    Laza-Stanca, V.2    Mallia, P.3
  • 61
    • 79960384534 scopus 로고    scopus 로고
    • Influenza A viruses: New research developments
    • Medina RA, Garcia-Sastre A. Influenza A viruses: new research developments. Nat Rev Microbiol 2011; 9: 590-603.
    • (2011) Nat Rev Microbiol , vol.9 , pp. 590-603
    • Medina, R.A.1    Garcia-Sastre, A.2
  • 62
    • 67449110743 scopus 로고    scopus 로고
    • Emergence of a novel swine-origin influenza A (H1N1) virus in humans
    • Dawood FS, Jain S, Finelli L, et al. Emergence of a novel swine-origin influenza A (H1N1) virus in humans. N Engl J Med 2009; 360: 2605-15.
    • (2009) N Engl J Med , vol.360 , pp. 2605-2615
    • Dawood, F.S.1    Jain, S.2    Finelli, L.3
  • 63
    • 67449152290 scopus 로고    scopus 로고
    • Triple-reassortant swine influenza A (H1) in humans in the United States 2005-2009
    • Shinde V, Bridges CB, Uyeki TM, et al. Triple-reassortant swine influenza A (H1) in humans in the United States, 2005-2009. N Engl J Med 2009; 360: 2616-25.
    • (2009) N Engl J Med , vol.360 , pp. 2616-2625
    • Shinde, V.1    Bridges, C.B.2    Uyeki, T.M.3
  • 64
    • 84856509782 scopus 로고    scopus 로고
    • Comparing pandemic to seasonal influenza mortality: Moderate impact overall but high mortality in young children
    • Wijngaard CC, Asten L, Koopmans MP, et al. Comparing pandemic to seasonal influenza mortality: moderate impact overall but high mortality in young children. PLoS One 2012; 7: e31197.
    • (2012) PLoS One , vol.7
    • Wijngaard, C.C.1    Asten, L.2    Koopmans, M.P.3
  • 65
    • 77953713048 scopus 로고    scopus 로고
    • Impact of the 2009 influenza pandemic
    • Dunning J, Openshaw PJ. Impact of the 2009 influenza pandemic. Thorax 2010; 65: 471-72.
    • (2010) Thorax , vol.65 , pp. 471-472
    • Dunning, J.1    Openshaw, P.J.2
  • 66
    • 77955286120 scopus 로고    scopus 로고
    • Risk factors for hospitalisation and poor outcome with pandemic A/H1N1 influenza: United Kingdom first wave (May-September 2009)
    • Nguyen-Van-Tam JS, Openshaw PJ, Hashim A, et al. Risk factors for hospitalisation and poor outcome with pandemic A/H1N1 influenza: United Kingdom first wave (May-September 2009). Thorax 2010; 65: 645-51.
    • (2010) Thorax , vol.65 , pp. 645-651
    • Nguyen-Van-Tam, J.S.1    Openshaw, P.J.2    Hashim, A.3
  • 67
    • 79960936455 scopus 로고    scopus 로고
    • Risk factors for severe outcomes following 2009 influenza A (H1N1) infection: A global pooled analysis
    • Van Kerkhove MD, Vandemaele KA, Shinde V, et al. Risk factors for severe outcomes following 2009 influenza A (H1N1) infection: a global pooled analysis. PLoS Med 2011; 8: e1001053.
    • (2011) PLoS Med , vol.8
    • Van Kerkhove, M.D.1    Vandemaele, K.A.2    Shinde, V.3
  • 68
    • 84862777209 scopus 로고    scopus 로고
    • IFITM3 restricts the morbidity and mortality associated with influenza
    • Everitt AR, Clare S, Pertel T, et al. IFITM3 restricts the morbidity and mortality associated with influenza. Nature 2012; 484: 519-23.
    • (2012) Nature , vol.484 , pp. 519-523
    • Everitt, A.R.1    Clare, S.2    Pertel, T.3
  • 69
    • 80052940381 scopus 로고    scopus 로고
    • Endothelial cells are central orchestrators of cytokine amplification during influenza virus infection
    • Teijaro JR, Walsh KB, Cahalan S, et al. Endothelial cells are central orchestrators of cytokine amplification during influenza virus infection. Cell 2011; 146: 980-91.
    • (2011) Cell , vol.146 , pp. 980-991
    • Teijaro, J.R.1    Walsh, K.B.2    Cahalan, S.3
  • 70
    • 80053567226 scopus 로고    scopus 로고
    • Quelling the storm: Utilization of sphingosine-1-phosphate receptor signaling to ameliorate influenza virus-induced cytokine storm
    • Walsh KB, Teijaro JR, Rosen H, Oldstone MB. Quelling the storm: utilization of sphingosine-1-phosphate receptor signaling to ameliorate influenza virus-induced cytokine storm. Immunol Res 2011; 51: 15-25.
    • (2011) Immunol Res , vol.51 , pp. 15-25
    • Walsh, K.B.1    Teijaro, J.R.2    Rosen, H.3    Oldstone, M.B.4
  • 71
    • 84870279179 scopus 로고    scopus 로고
    • Prediction and prevention of the next pandemic zoonosis
    • Morse SS, Mazet JA, Woolhouse M, et al. Prediction and prevention of the next pandemic zoonosis. Lancet 2012; 380: 1956-65.
    • (2012) Lancet , vol.380 , pp. 1956-1965
    • Morse, S.S.1    Mazet, J.A.2    Woolhouse, M.3
  • 72
    • 77249092615 scopus 로고    scopus 로고
    • New insights into innate immune mechanisms underlying allergenicity
    • Wills-Karp M, Nathan A, Page K, Karp CL. New insights into innate immune mechanisms underlying allergenicity. Mucosal Immunol 2010; 3: 104-10.
    • (2010) Mucosal Immunol , vol.3 , pp. 104-110
    • Wills-Karp, M.1    Nathan, A.2    Page, K.3    Karp, C.L.4
  • 73
    • 59049100417 scopus 로고    scopus 로고
    • Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein
    • Trompette A, Divanovic S, Visintin A, et al. Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein. Nature 2009; 457: 585-88.
    • (2009) Nature , vol.457 , pp. 585-588
    • Trompette, A.1    Divanovic, S.2    Visintin, A.3
  • 74
    • 64149087970 scopus 로고    scopus 로고
    • House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells
    • Hammad H, Chieppa M, Perros F, Willart MA, Germain RN, Lambrecht BN. House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells. Nat Med 2009; 15: 410-16.
    • (2009) Nat Med , vol.15 , pp. 410-416
    • Hammad, H.1    Chieppa, M.2    Perros, F.3    Willart, M.A.4    Germain, R.N.5    Lambrecht, B.N.6
  • 75
    • 77950878748 scopus 로고    scopus 로고
    • Functional interaction of common allergens and a C-type lectin receptor, dendritic cell-specific ICAM3-grabbing non-integrin (DC-SIGN), on human dendritic cells
    • Hsu SC, Chen CH, Tsai SH, et al. Functional interaction of common allergens and a C-type lectin receptor, dendritic cell-specific ICAM3-grabbing non-integrin (DC-SIGN), on human dendritic cells. J Biol Chem 2010; 285: 7903-10.
    • (2010) J Biol Chem , vol.285 , pp. 7903-7910
    • Hsu, S.C.1    Chen, C.H.2    Tsai, S.H.3
  • 76
    • 79951972586 scopus 로고    scopus 로고
    • Exposure to environmental microorganisms and childhood asthma
    • Ege MJ, Mayer M, Normand AC, et al. Exposure to environmental microorganisms and childhood asthma. N Engl J Med 2011;364: 701-09.
    • (2011) N Engl J Med , vol.364 , pp. 701-709
    • Ege, M.J.1    Mayer, M.2    Normand, A.C.3
  • 77
    • 84862840210 scopus 로고    scopus 로고
    • Does diversity of environmental microbial exposure matter for the occurrence of allergy and asthma?
    • Heederik D, von Mutius E. Does diversity of environmental microbial exposure matter for the occurrence of allergy and asthma? J Allergy Clin Immunol 2012; 130: 44-50.
    • (2012) J Allergy Clin Immunol , vol.130 , pp. 44-50
    • Heederik, D.1    Von Mutius, E.2
  • 78
    • 80053576562 scopus 로고    scopus 로고
    • Effect of prenatal indoor pet exposure on the trajectory of total IgE levels in early childhood
    • Havstad S, Wegienka G, Zoratti EM, et al. Effect of prenatal indoor pet exposure on the trajectory of total IgE levels in early childhood. J Allergy Clin Immunol 2011; 128: 880-85.
    • (2011) J Allergy Clin Immunol , vol.128 , pp. 880-885
    • Havstad, S.1    Wegienka, G.2    Zoratti, E.M.3
  • 79
    • 0038340259 scopus 로고    scopus 로고
    • Control of exposure to mite allergen and allergen-impermeable bed covers for adults with asthma
    • Woodcock A, Forster L, Matthews E, et al. Control of exposure to mite allergen and allergen-impermeable bed covers for adults with asthma. N Engl J Med 2003; 349: 225-36.
    • (2003) N Engl J Med , vol.349 , pp. 225-236
    • Woodcock, A.1    Forster, L.2    Matthews, E.3
  • 80
    • 84856444202 scopus 로고    scopus 로고
    • Fungi and allergic lower respiratory tract diseases
    • Knutsen AP, Bush RK, Demain JG, et al. Fungi and allergic lower respiratory tract diseases. J Allergy Clin Immunol 2012; 129: 280-91.
    • (2012) J Allergy Clin Immunol , vol.129 , pp. 280-291
    • Knutsen, A.P.1    Bush, R.K.2    Demain, J.G.3
  • 82
    • 58349115630 scopus 로고    scopus 로고
    • Randomized controlled trial of oral antifungal treatment for severe asthma with fungal sensitization: The Fungal Asthma Sensitization Trial (FAST) study
    • Denning DW, O'Driscoll BR, Powell G, et al. Randomized controlled trial of oral antifungal treatment for severe asthma with fungal sensitization: the Fungal Asthma Sensitization Trial (FAST) study. Am J Respir Crit Care Med 2009; 179: 11-18.
    • (2009) Am J Respir Crit Care Med , vol.179 , pp. 11-18
    • Denning, D.W.1    O'Driscoll, B.R.2    Powell, G.3
  • 83
    • 84860691114 scopus 로고    scopus 로고
    • The airway epithelium in asthma
    • Lambrecht BN, Hammad H. The airway epithelium in asthma. Nat Med 2012; 18: 684-92.
    • (2012) Nat Med , vol.18 , pp. 684-692
    • Lambrecht, B.N.1    Hammad, H.2
  • 84
    • 80052219553 scopus 로고    scopus 로고
    • Defective epithelial barrier function in asthma
    • Xiao C, Puddicombe SM, Field S, et al. Defective epithelial barrier function in asthma. J Allergy Clin Immunol 2011; 128: 549-56.
    • (2011) J Allergy Clin Immunol , vol.128 , pp. 549-556
    • Xiao, C.1    Puddicombe, S.M.2    Field, S.3
  • 85
    • 80052347488 scopus 로고    scopus 로고
    • Host epithelial-viral interactions as cause and cure for asthma
    • Holtzman MJ, Patel DA, Zhang Y, Patel AC. Host epithelial-viral interactions as cause and cure for asthma. Curr Opin Immunol 2011; 23: 487-94.
    • (2011) Curr Opin Immunol , vol.23 , pp. 487-494
    • Holtzman, M.J.1    Patel, D.A.2    Zhang, Y.3    Patel, A.C.4
  • 86
    • 84879608081 scopus 로고    scopus 로고
    • Impaired type i and III interferon response to rhinovirus infection during pregnancy and asthma
    • Forbes RL, Gibson PG, Murphy VE, Wark PA. Impaired type I and III interferon response to rhinovirus infection during pregnancy and asthma. Thorax 2012; 67: 209-14.
    • (2012) Thorax , vol.67 , pp. 209-214
    • Forbes, R.L.1    Gibson, P.G.2    Murphy, V.E.3    Wark, P.A.4
  • 87
    • 84861654883 scopus 로고    scopus 로고
    • Rhinovirus 16-induced IFN-alpha and IFN-beta are deficient in bronchoalveolar lavage cells in asthmatic patients
    • Sykes A, Edwards MR, Macintyre J, et al. Rhinovirus 16-induced IFN-alpha and IFN-beta are deficient in bronchoalveolar lavage cells in asthmatic patients. J Allergy Clin Immunol 2012; 129: 1506-14.
    • (2012) J Allergy Clin Immunol , vol.129 , pp. 1506-1514
    • Sykes, A.1    Edwards, M.R.2    MacIntyre, J.3
  • 88
    • 84870291769 scopus 로고    scopus 로고
    • Deficient antiviral immune responses in childhood: Distinct roles of atopy and asthma
    • Baraldo S, Contoli M, Bazzan E, et al. Deficient antiviral immune responses in childhood: Distinct roles of atopy and asthma. J Allergy Clin Immunol 2012; 130: 1307-14.
    • (2012) J Allergy Clin Immunol , vol.130 , pp. 1307-1314
    • Baraldo, S.1    Contoli, M.2    Bazzan, E.3
  • 89
    • 77956366626 scopus 로고    scopus 로고
    • The role of dendritic and epithelial cells as master regulators of allergic airway inflammation
    • Lambrecht BN, Hammad H. The role of dendritic and epithelial cells as master regulators of allergic airway inflammation. Lancet 2010; 376: 835-43.
    • (2010) Lancet , vol.376 , pp. 835-843
    • Lambrecht, B.N.1    Hammad, H.2
  • 91
    • 84860357324 scopus 로고    scopus 로고
    • Trefoil factor 2 rapidly induces interleukin 33 to promote type 2 immunity during allergic asthma and hookworm infection
    • Wills-Karp M, Rani R, Dienger K, et al. Trefoil factor 2 rapidly induces interleukin 33 to promote type 2 immunity during allergic asthma and hookworm infection. J Exp Med 2012; 209: 607-22.
    • (2012) J Exp Med , vol.209 , pp. 607-622
    • Wills-Karp, M.1    Rani, R.2    Dienger, K.3
  • 92
    • 84857640602 scopus 로고    scopus 로고
    • The alarmin interleukin-33 drives protective antiviral CD8 T cell responses
    • Bonilla WV, Frohlich A, Senn K, et al. The alarmin interleukin-33 drives protective antiviral CD8 T cell responses. Science 2012; 335: 984-89.
    • (2012) Science , vol.335 , pp. 984-989
    • Bonilla, W.V.1    Frohlich, A.2    Senn, K.3
  • 93
    • 84860697146 scopus 로고    scopus 로고
    • T cell homing to epithelial barriers in allergic disease
    • Islam SA, Luster AD. T cell homing to epithelial barriers in allergic disease. Nat Med 2012; 18: 705-15.
    • (2012) Nat Med , vol.18 , pp. 705-715
    • Islam, S.A.1    Luster, A.D.2
  • 94
    • 84858273561 scopus 로고    scopus 로고
    • A large subgroup of mild-to-moderate asthma is persistently noneosinophilic
    • McGrath KW, Icitovic N, Boushey HA, et al. A large subgroup of mild-to-moderate asthma is persistently noneosinophilic. Am J Respir Crit Care Med 2012; 185: 612-19.
    • (2012) Am J Respir Crit Care Med , vol.185 , pp. 612-619
    • McGrath, K.W.1    Icitovic, N.2    Boushey, H.A.3
  • 95
    • 84865145614 scopus 로고    scopus 로고
    • Mepolizumab for severe eosinophilic asthma (DREAM): A multicentre, double-blind, placebo-controlled trial
    • Pavord ID, Korn S, Howarth P, et al. Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial. Lancet 2012; 380: 651-59.
    • (2012) Lancet , vol.380 , pp. 651-659
    • Pavord, I.D.1    Korn, S.2    Howarth, P.3
  • 96
    • 79251582522 scopus 로고    scopus 로고
    • Gene expression patterns of Th2 inflammation and intercellular communication in asthmatic airways
    • Choy DF, Modrek B, Abbas AR, et al. Gene expression patterns of Th2 inflammation and intercellular communication in asthmatic airways. J Immunol 2011; 186: 1861-69.
    • (2011) J Immunol , vol.186 , pp. 1861-1869
    • Choy, D.F.1    Modrek, B.2    Abbas, A.R.3
  • 97
    • 84872977452 scopus 로고    scopus 로고
    • Innate lymphoid cells-a proposal for uniform nomenclature
    • Spits H, Artis D, Colonna M, et al. Innate lymphoid cells-a proposal for uniform nomenclature. Nat Rev Immunol 2013; 13: 145-49.
    • (2013) Nat Rev Immunol , vol.13 , pp. 145-149
    • Spits, H.1    Artis, D.2    Colonna, M.3
  • 98
    • 84865000814 scopus 로고    scopus 로고
    • Innate type 2 cells and asthma
    • Hams E, Fallon PG. Innate type 2 cells and asthma. Curr Opin Pharmacol 2012; 12: 503-09.
    • (2012) Curr Opin Pharmacol , vol.12 , pp. 503-509
    • Hams, E.1    Fallon, P.G.2
  • 99
    • 80052664252 scopus 로고    scopus 로고
    • Alternatively activated macrophages and airway disease
    • Byers DE, Holtzman MJ. Alternatively activated macrophages and airway disease. Chest 2011; 140: 768-74.
    • (2011) Chest , vol.140 , pp. 768-774
    • Byers, D.E.1    Holtzman, M.J.2
  • 100
    • 84860668874 scopus 로고    scopus 로고
    • IgE and mast cells in allergic disease
    • Galli SJ, Tsai M. IgE and mast cells in allergic disease. Nat Med 2012; 18: 693-704.
    • (2012) Nat Med , vol.18 , pp. 693-704
    • Galli, S.J.1    Tsai, M.2
  • 101
    • 42249088428 scopus 로고    scopus 로고
    • Eosinophils: Biological properties and role in health and disease
    • Hogan SP, Rosenberg HF, Moqbel R, et al. Eosinophils: biological properties and role in health and disease. Clin Exp Allergy 2008; 38: 709-50.
    • (2008) Clin Exp Allergy , vol.38 , pp. 709-750
    • Hogan, S.P.1    Rosenberg, H.F.2    Moqbel, R.3
  • 102
    • 67049144615 scopus 로고    scopus 로고
    • Eosinophilic and neutrophilic inflammation in asthma: Insights from clinical studies
    • Fahy JV. Eosinophilic and neutrophilic inflammation in asthma: insights from clinical studies. Proc Am Thorac Soc 2009; 6: 256-59.
    • (2009) Proc Am Thorac Soc , vol.6 , pp. 256-259
    • Fahy, J.V.1
  • 103
    • 84860655039 scopus 로고    scopus 로고
    • Innate and adaptive immune responses in asthma
    • Holgate ST. Innate and adaptive immune responses in asthma. Nat Med 2012; 18: 673-83.
    • (2012) Nat Med , vol.18 , pp. 673-683
    • Holgate, S.T.1
  • 104
    • 84865385470 scopus 로고    scopus 로고
    • Altered regulation of Toll-like receptor responses impairs antibacterial immunity in the allergic lung
    • Habibzay M, Saldana JI, Goulding J, Lloyd CM, Hussell T. Altered regulation of Toll-like receptor responses impairs antibacterial immunity in the allergic lung. Mucosal Immunol 2012; 5: 524-34.
    • (2012) Mucosal Immunol , vol.5 , pp. 524-534
    • Habibzay, M.1    Saldana, J.I.2    Goulding, J.3    Lloyd, C.M.4    Hussell, T.5
  • 105
    • 79251492014 scopus 로고    scopus 로고
    • Co-ordinated role of TLR3, RIG-I and MDA5 in the innate response to rhinovirus in bronchial epithelium
    • Slater L, Bartlett N W, Haas JJ, et al. Co-ordinated role of TLR3, RIG-I and MDA5 in the innate response to rhinovirus in bronchial epithelium. PLoS Pathog 2010; 6: e1001178.
    • (2010) PLoS Pathog , vol.6
    • Slater, L.1    Bartlett, N.W.2    Haas, J.J.3
  • 106
    • 84865032889 scopus 로고    scopus 로고
    • New developments in Toll-like receptor targeted therapeutics
    • Connolly DJ, O'Neill LA. New developments in Toll-like receptor targeted therapeutics. Curr Opin Pharmacol 2012; 12: 510-18.
    • (2012) Curr Opin Pharmacol , vol.12 , pp. 510-518
    • Connolly, D.J.1    O'Neill, L.A.2
  • 107
    • 84860679595 scopus 로고    scopus 로고
    • Asthma phenotypes: The evolution from clinical to molecular approaches
    • Wenzel SE. Asthma phenotypes: the evolution from clinical to molecular approaches. Nat Med 2012; 18: 716-25.
    • (2012) Nat Med , vol.18 , pp. 716-725
    • Wenzel, S.E.1
  • 109
    • 84868148926 scopus 로고    scopus 로고
    • Cord blood Th2-related chemokine CCL22 levels associate with elevated total-IgE during preschool age
    • Folsgaard NV, Chawes BL, Bonnelykke K, Jenmalm MC, Bisgaard H. Cord blood Th2-related chemokine CCL22 levels associate with elevated total-IgE during preschool age. Clin Exp Allergy 2012; 42: 1596-603.
    • (2012) Clin Exp Allergy , vol.42 , pp. 1596-1603
    • Folsgaard, N.V.1    Chawes, B.L.2    Bonnelykke, K.3    Jenmalm, M.C.4    Bisgaard, H.5
  • 110
    • 82155173521 scopus 로고    scopus 로고
    • A Th1/Th2-associated chemokine imbalance during infancy in children developing eczema, wheeze and sensitization
    • Abrahamsson TR, Sandberg AM, Forsberg A, Bjorksten B, Jenmalm MC. A Th1/Th2-associated chemokine imbalance during infancy in children developing eczema, wheeze and sensitization. Clin Exp Allergy 2011; 41: 1729-39.
    • (2011) Clin Exp Allergy , vol.41 , pp. 1729-1739
    • Abrahamsson, T.R.1    Sandberg, A.M.2    Forsberg, A.3    Bjorksten, B.4    Jenmalm, M.C.5
  • 111
    • 84860492288 scopus 로고    scopus 로고
    • Antiviral IFN-gamma responses of monocytes at birth predict respiratory tract illness in the first year of life
    • Sumino K, Tucker J, Shahab M, et al. Antiviral IFN-gamma responses of monocytes at birth predict respiratory tract illness in the first year of life. J Allergy Clin Immunol 2012; 129: 1267-73.
    • (2012) J Allergy Clin Immunol , vol.129 , pp. 1267-1273
    • Sumino, K.1    Tucker, J.2    Shahab, M.3
  • 112
    • 77956359249 scopus 로고    scopus 로고
    • Environmental epigenetics of asthma: An update
    • Ho SM. Environmental epigenetics of asthma: an update. J Allergy Clin Immunol 2010; 126: 453-65.
    • (2010) J Allergy Clin Immunol , vol.126 , pp. 453-465
    • Ho, S.M.1
  • 114
    • 35248851540 scopus 로고    scopus 로고
    • Childhood asthma after bacterial colonization of the airway in neonates
    • Bisgaard H, Hermansen MN, Buchvald F, et al. Childhood asthma after bacterial colonization of the airway in neonates. N Engl J Med 2007; 357: 1487-95.
    • (2007) N Engl J Med , vol.357 , pp. 1487-1495
    • Bisgaard, H.1    Hermansen, M.N.2    Buchvald, F.3
  • 115
    • 84856810029 scopus 로고    scopus 로고
    • Neonatal cytokine profile in the airway mucosal lining fluid is skewed by maternal atopy
    • Folsgaard NV, Chawes BL, Rasmussen MA, et al. Neonatal cytokine profile in the airway mucosal lining fluid is skewed by maternal atopy. Am J Respir Crit Care Med 2012; 185: 275-80.
    • (2012) Am J Respir Crit Care Med , vol.185 , pp. 275-280
    • Folsgaard, N.V.1    Chawes, B.L.2    Rasmussen, M.A.3
  • 116
    • 79952741584 scopus 로고    scopus 로고
    • Respiratory syncytial virus prevention and therapy: Past, present, and future
    • Wright M, Piedimonte G. Respiratory syncytial virus prevention and therapy: past, present, and future. Pediatr Pulmonol 2011; 46: 324-47.
    • (2011) Pediatr Pulmonol , vol.46 , pp. 324-347
    • Wright, M.1    Piedimonte, G.2
  • 117
    • 84864476809 scopus 로고    scopus 로고
    • Neonatal bronchial hyperresponsiveness precedes acute severe viral bronchiolitis in infants
    • Chawes BL, Poorisrisak P, Johnston SL, Bisgaard H. Neonatal bronchial hyperresponsiveness precedes acute severe viral bronchiolitis in infants. J Allergy Clin Immunol 2012; 130: 354-61.
    • (2012) J Allergy Clin Immunol , vol.130 , pp. 354-361
    • Chawes, B.L.1    Poorisrisak, P.2    Johnston, S.L.3    Bisgaard, H.4
  • 118
    • 57149086352 scopus 로고    scopus 로고
    • Definition, assessment and treatment of wheezing disorders in preschool children: An evidence-based approach
    • Brand PL, Baraldi E, Bisgaard H, et al. Definition, assessment and treatment of wheezing disorders in preschool children: an evidence-based approach. Eur Respir J 2008; 32: 1096-110.
    • (2008) Eur Respir J , vol.32 , pp. 1096-1110
    • Brand, P.L.1    Baraldi, E.2    Bisgaard, H.3
  • 119
    • 79960008036 scopus 로고    scopus 로고
    • The relationship of rhinitis and asthma, sinusitis, food allergy, and eczema
    • Tan RA, Corren J. The relationship of rhinitis and asthma, sinusitis, food allergy, and eczema. Immunol Allergy Clin North Am 2011;31: 481-91.
    • (2011) Immunol Allergy Clin North Am , vol.31 , pp. 481-491
    • Tan, R.A.1    Corren, J.2
  • 120
    • 74849094691 scopus 로고    scopus 로고
    • Phenotypic differences between pediatric and adult asthma
    • Bush A, Menzies-Gow A. Phenotypic differences between pediatric and adult asthma. Proc Am Thorac Soc 2009; 6: 712-19.
    • (2009) Proc Am Thorac Soc , vol.6 , pp. 712-719
    • Bush, A.1    Menzies-Gow, A.2
  • 121
    • 79551495183 scopus 로고    scopus 로고
    • Airway microbiota and bronchial hyperresponsiveness in patients with suboptimally controlled asthma
    • Huang YJ, Nelson CE, Brodie EL, et al. Airway microbiota and bronchial hyperresponsiveness in patients with suboptimally controlled asthma. J Allergy Clin Immunol 2011; 127: 372-81.
    • (2011) J Allergy Clin Immunol , vol.127 , pp. 372-381
    • Huang, Y.J.1    Nelson, C.E.2    Brodie, E.L.3
  • 122
    • 79952588219 scopus 로고    scopus 로고
    • Asthma and ageing: An end user's perspective-the perception and problems with the management of asthma in the elderly
    • Jones SC, Iverson D, Burns P, Evers U, Caputi P, Morgan S. Asthma and ageing: an end user's perspective-the perception and problems with the management of asthma in the elderly. Clin Exp Allergy 2011; 41: 471-81.
    • (2011) Clin Exp Allergy , vol.41 , pp. 471-481
    • Jones, S.C.1    Iverson, D.2    Burns, P.3    Evers, U.4    Caputi, P.5    Morgan, S.6
  • 123
    • 80053085384 scopus 로고    scopus 로고
    • Asthma phenotypes and interleukin-13-moving closer to personalized medicine
    • Kraft M. Asthma phenotypes and interleukin-13-moving closer to personalized medicine. N Engl J Med 2011; 365: 1141-44.
    • (2011) N Engl J Med , vol.365 , pp. 1141-1144
    • Kraft, M.1
  • 124
    • 78649673636 scopus 로고    scopus 로고
    • Efficacy and safety of subcutaneous omalizumab vs placebo as add-on therapy to corticosteroids for children and adults with asthma: A systematic review
    • Rodrigo GJ, Neffen H, Castro-Rodriguez JA. Efficacy and safety of subcutaneous omalizumab vs placebo as add-on therapy to corticosteroids for children and adults with asthma: a systematic review. Chest 2011; 139: 28-35.
    • (2011) Chest , vol.139 , pp. 28-35
    • Rodrigo, G.J.1    Neffen, H.2    Castro-Rodriguez, J.A.3
  • 125
    • 61849155730 scopus 로고    scopus 로고
    • Mepolizumab for prednisone-dependent asthma with sputum eosinophilia
    • Nair P, Pizzichini MM, Kjarsgaard M, et al. Mepolizumab for prednisone-dependent asthma with sputum eosinophilia. N Engl J Med 2009; 360: 985-93.
    • (2009) N Engl J Med , vol.360 , pp. 985-993
    • Nair, P.1    Pizzichini, M.M.2    Kjarsgaard, M.3
  • 126
    • 61849086181 scopus 로고    scopus 로고
    • Mepolizumab and exacerbations of refractory eosinophilic asthma
    • Haldar P, Brightling CE, Hargadon B, et al. Mepolizumab and exacerbations of refractory eosinophilic asthma. N Engl J Med 2009; 360: 973-84.
    • (2009) N Engl J Med , vol.360 , pp. 973-984
    • Haldar, P.1    Brightling, C.E.2    Hargadon, B.3
  • 127
    • 84860010929 scopus 로고    scopus 로고
    • Molecular and clinical rationale for therapeutic targeting of interleukin-5 and its receptor
    • Molfino NA, Gossage D, Kolbeck R, Parker JM, Geba GP. Molecular and clinical rationale for therapeutic targeting of interleukin-5 and its receptor. Clin Exp Allergy 2012; 42: 712-37.
    • (2012) Clin Exp Allergy , vol.42 , pp. 712-737
    • Molfino, N.A.1    Gossage, D.2    Kolbeck, R.3    Parker, J.M.4    Geba, G.P.5
  • 128
    • 80053084755 scopus 로고    scopus 로고
    • Lebrikizumab treatment in adults with asthma
    • Corren J, Lemanske RF, Hanania NA, et al. Lebrikizumab treatment in adults with asthma. N Engl J Med 2011; 365: 1088-98.
    • (2011) N Engl J Med , vol.365 , pp. 1088-1098
    • Corren, J.1    Lemanske, R.F.2    Hanania, N.A.3
  • 129
    • 84869100349 scopus 로고    scopus 로고
    • IL-13 in asthma and allergic disease: Asthma phenotypes and targeted therapies
    • Ingram JL, Kraft M. IL-13 in asthma and allergic disease: asthma phenotypes and targeted therapies. J Allergy Clin Immunol 2012; 130: 829-42.
    • (2012) J Allergy Clin Immunol , vol.130 , pp. 829-842
    • Ingram, J.L.1    Kraft, M.2
  • 130
    • 80053568990 scopus 로고    scopus 로고
    • The effects of an anti-IL-13 mAb on cytokine levels and nasal symptoms following nasal allergen challenge
    • Nicholson GC, Kariyawasam HH, Tan AJ, et al. The effects of an anti-IL-13 mAb on cytokine levels and nasal symptoms following nasal allergen challenge. J Allergy Clin Immunol 2011; 128: 800-07.
    • (2011) J Allergy Clin Immunol , vol.128 , pp. 800-807
    • Nicholson, G.C.1    Kariyawasam, H.H.2    Tan, A.J.3
  • 131
    • 34548501513 scopus 로고    scopus 로고
    • The allergen bronchoprovocation model: An important tool for the investigation of new asthma anti-inflammatory therapies
    • Boulet LP, Gauvreau G, Boulay ME, O'Byrne P, Cockcroft DW. The allergen bronchoprovocation model: an important tool for the investigation of new asthma anti-inflammatory therapies. Allergy 2007; 62: 1101-10.
    • (2007) Allergy , vol.62 , pp. 1101-1110
    • Boulet, L.P.1    Gauvreau, G.2    Boulay, M.E.3    O'Byrne, P.4    Cockcroft, D.W.5
  • 133
    • 84869802120 scopus 로고    scopus 로고
    • Human microbial challenge: The ultimate animal model
    • Pollard AJ, Savulescu J, Oxford J, et al. Human microbial challenge: the ultimate animal model. Lancet Infect Dis 2012; 12: 903-05.
    • (2012) Lancet Infect Dis , vol.12 , pp. 903-905
    • Pollard, A.J.1    Savulescu, J.2    Oxford, J.3
  • 134
    • 67651222099 scopus 로고    scopus 로고
    • Similar colds in subjects with allergic asthma and nonatopic subjects after inoculation with rhinovirus-16
    • DeMore JP, Weisshaar EH, Vrtis RF, et al. Similar colds in subjects with allergic asthma and nonatopic subjects after inoculation with rhinovirus-16. J Allergy Clin Immunol 2009; 124: 245-52.
    • (2009) J Allergy Clin Immunol , vol.124 , pp. 245-252
    • Demore, J.P.1    Weisshaar, E.H.2    Vrtis, R.F.3
  • 135
    • 78349243640 scopus 로고    scopus 로고
    • Viral load drives disease in humans experimentally infected with respiratory syncytial virus
    • DeVincenzo JP, Wilkinson T, Vaishnaw A, et al. Viral load drives disease in humans experimentally infected with respiratory syncytial virus. Am J Respir Crit Care Med 2010; 182: 1305-14.
    • (2010) Am J Respir Crit Care Med , vol.182 , pp. 1305-1314
    • Devincenzo, J.P.1    Wilkinson, T.2    Vaishnaw, A.3
  • 136
    • 62949237235 scopus 로고    scopus 로고
    • DNA vaccination protects against an influenza challenge in a double-blind randomised placebo-controlled phase 1b clinical trial
    • Jones S, Evans K, McElwaine-Johnn H, et al. DNA vaccination protects against an influenza challenge in a double-blind randomised placebo-controlled phase 1b clinical trial. Vaccine 2009; 27: 2506-12.
    • (2009) Vaccine , vol.27 , pp. 2506-2512
    • Jones, S.1    Evans, K.2    McElwaine-Johnn, H.3
  • 137
    • 84869110016 scopus 로고    scopus 로고
    • Atopic asthmatic patients have reduced airway inflammatory cell recruitment after inhaled endotoxin challenge compared with healthy volunteers
    • Hernandez ML, Herbst M, Lay JC, et al. Atopic asthmatic patients have reduced airway inflammatory cell recruitment after inhaled endotoxin challenge compared with healthy volunteers. J Allergy Clin Immunol 2012; 130: 869-76.
    • (2012) J Allergy Clin Immunol , vol.130 , pp. 869-876
    • Hernandez, M.L.1    Herbst, M.2    Lay, J.C.3
  • 138
    • 70249134919 scopus 로고    scopus 로고
    • Molecular networks as sensors and drivers of common human diseases
    • Schadt EE. Molecular networks as sensors and drivers of common human diseases. Nature 2009; 461: 218-23.
    • (2009) Nature , vol.461 , pp. 218-223
    • Schadt, E.E.1
  • 139
    • 84855378129 scopus 로고    scopus 로고
    • NEW: Network-enabled wisdom in biology, medicine, and health care
    • Schadt EE, Bjorkegren JL. NEW: network-enabled wisdom in biology, medicine, and health care. Sci Transl Med 2012; 4: 115rv1.
    • (2012) Sci Transl Med , vol.4
    • Schadt, E.E.1    Bjorkegren, J.L.2
  • 140
    • 77953303583 scopus 로고    scopus 로고
    • An integrative systems biology approach to understanding pulmonary diseases
    • Auffray C, Adcock IM, Chung KF, Djukanovic R, Pison C, Sterk PJ. An integrative systems biology approach to understanding pulmonary diseases. Chest 2010; 137: 1410-16.
    • (2010) Chest , vol.137 , pp. 1410-1416
    • Auffray, C.1    Adcock, I.M.2    Chung, K.F.3    Djukanovic, R.4    Pison, C.5    Sterk, P.J.6
  • 141
    • 82955248055 scopus 로고    scopus 로고
    • New insights into asthma pathogenesis and treatment
    • Szefler SJ, Dakhama A. New insights into asthma pathogenesis and treatment. Curr Opin Immunol 2011; 23: 801-07.
    • (2011) Curr Opin Immunol , vol.23 , pp. 801-807
    • Szefler, S.J.1    Dakhama, A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.