ER stress and ER stress-mediated apoptosis are involved in manganese-induced neurotoxicity in the rat striatum in vivo

NeuroToxicology

Volumn 48, Issue , 2015, Pages 109-119

  Wang, Ting ^a,b   Li, Xuehui ^a   Yang, Dongxu ^a   Zhang, Hongtao ^a   Zhao, Peng ^a   Fu, Juanling ^a   Yao, Biyun ^a   Zhou, Zongcan ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b The seventh people hospital of Zhengzhou   (China)

Author keywords

Apoptosis; Endoplasmic reticulum stress; Manganese; Neurotoxicity; Striatum

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 6; ACTIVATING TRANSCRIPTION FACTOR 6 ALPHA; BIM PROTEIN; CASPASE 12; CASPASE 3; GLUCOSE REGULATED PROTEIN 78; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; IRE 1 PROTEIN; MANGANESE CHLORIDE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN PERK; PROTEIN SERINE THREONINE KINASE; SIGMA 1 OPIATE RECEPTOR; UNCLASSIFIED DRUG; APOPTOSIS REGULATORY PROTEIN; CHLORIDE; MANGANESE DERIVATIVE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BIOACCUMULATION; BRAIN CELL; BRAIN MITOCHONDRION; CELL SWELLING; CHLOROPHYLL CONTENT; CHROMATIN CONDENSATION; CONTROLLED STUDY; CORPUS STRIATUM; ENDOPLASMIC RETICULUM STRESS; EOSINOPHIL COUNT; FEMALE; IN VIVO STUDY; MALE; NERVE CELL DEGENERATION; NEUROTOXICITY; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; RAT; ULTRASTRUCTURE; ANIMAL; DOSE RESPONSE; DRUG EFFECTS; ENDOPLASMIC RETICULUM; MANGANESE POISONING; METABOLISM; NERVE CELL; PATHOLOGY; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT; TIME;

RATTUS;

ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CHLORIDES; CORPUS STRIATUM; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; FEMALE; MALE; MANGANESE COMPOUNDS; MANGANESE POISONING; NEURONS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 84926024405     PISSN: 0161813X     EISSN: 18729711     Source Type: Journal    
DOI: 10.1016/j.neuro.2015.02.007     Document Type: Article

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