The hyperglycemia stimulated myocardial endoplasmic reticulum (ER) stress contributes to diabetic cardiomyopathy in the transgenic non-obese type 2 diabetic rats: A differential role of unfolded protein response (UPR) signaling proteins

International Journal of Biochemistry and Cell Biology

Volumn 45, Issue 2, 2013, Pages 438-447

  Lakshmanan, Arun Prasath ^a   Harima, Meilei ^a   Suzuki, Kenji ^b   Soetikno, Vivian ^a   Nagata, Masaki ^b   Nakamura, Takashi ^a   Takahashi, Toshihiro ^c   Sone, Hirohito ^d   Kawachi, Hiroshi ^b   Watanabe, Kenichi ^a  

^a NIIGATA UNIVERSITY OF PHARMACY AND APPLIED LIFE SCIENCES   (Japan)

^b NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

^c NIIGATA UNIVERSITY   (Japan)

^d NIIGATA UNIVERSITY   (Japan)

Author keywords

ATF6; ERS; IRE 1 XBP1 pathway; PERK CHOP GADD153 axis; Spontaneous Diabetic Torii

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 6; CARNITINE PALMITOYLTRANSFERASE I; CASPASE 12; CASPASE 7; CYTOCHROME C; GLUCOSE TRANSPORTER 4; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INITIATION FACTOR 2ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOTRANSFERASE; PROTEIN BAD; PROTEIN KINASE B; PROTEIN KINASE RNA LIKE ENDOPLASMIC RETICULUM KINASE; SIGNAL PEPTIDE; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 2; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DIABETIC CARDIOMYOPATHY; ENDOPLASMIC RETICULUM STRESS; GLUCOSE METABOLISM; HYPERGLYCEMIA; INSULIN RESPONSE; LIPID METABOLISM; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; UNFOLDED PROTEIN RESPONSE; UPREGULATION;

ACTIVATING TRANSCRIPTION FACTOR 6; ANIMALS; APOPTOSIS; DIABETES MELLITUS, TYPE 2; DIABETIC CARDIOMYOPATHIES; ENDOPLASMIC RETICULUM STRESS; HYPERGLYCEMIA; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MAP KINASE SIGNALING SYSTEM; MYOCARDIUM; OXIDATIVE STRESS; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; RATS, TRANSGENIC; UNFOLDED PROTEIN RESPONSE;

RATTUS;

EID: 84872330613     PISSN: 13572725     EISSN: 18785875     Source Type: Journal    
DOI: 10.1016/j.biocel.2012.09.017     Document Type: Article

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