Manganese-induced oxidative DNA damage in neuronal SH-SY5Y cells: Attenuation of thymine base lesions by glutathione and N-acetylcysteine

Toxicology Letters

Volumn 218, Issue 3, 2013, Pages 299-307

  Stephenson, Adrienne P ^a   Schneider, Jeffrey A ^b   Nelson, Bryant C ^b   Atha, Donald H ^b   Jain, Ashok ^a   Soliman, Karam F A ^a   Aschner, Michael ^c   Mazzio, Elizabeth ^a   Renee Reams, R ^a  

^a FLORIDA A AND M UNIVERSITY   (United States)

^b NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY   (United States)

^c VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Antioxidants; DNA damage; Manganese; Oxidative stress; SH SY5Y cells; Thymine base

Indexed keywords

ACETYLCYSTEINE; ANTIOXIDANT; DNA; GLUTATHIONE; LIPOCORTIN 5; MANGANESE; PROPIDIUM IODIDE; THYMINE;

APOPTOSIS; ARTICLE; CELL DAMAGE; CELL PROTECTION; CELL VIABILITY; COMET ASSAY; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; DNA MODIFICATION; GAS CHROMATOGRAPHY; HUMAN; HUMAN CELL; INCUBATION TIME; LD 50; MASS SPECTROMETRY; NEUROBLASTOMA CELL; OXIDATIVE STRESS; PRIORITY JOURNAL; SINGLE STRANDED DNA BREAK;

ACETYLCYSTEINE; ANTIOXIDANTS; APOPTOSIS; CELL LINE, TUMOR; CELL SURVIVAL; CHLORIDES; COMET ASSAY; DNA BREAKS, SINGLE-STRANDED; DOSE-RESPONSE RELATIONSHIP, DRUG; FLOW CYTOMETRY; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GLUTATHIONE; HUMANS; IN SITU NICK-END LABELING; MANGANESE COMPOUNDS; MANGANESE POISONING; NEURONS; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; THYMINE;

EID: 84875623007     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2012.12.024     Document Type: Article

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