Endoplasmic reticulum stress signaling involvement in manganese-induced nerve cell damage in organotypic brain slice cultures

Toxicology Letters

Volumn 222, Issue 3, 2013, Pages 239-246

  Xu, Bin ^a   Shan, Ming ^a   Wang, Fei ^a   Deng, Yu ^a   Liu, Wei ^a   Feng, Shu ^a   Yang, Tian Yao ^a   Xu, Zhao Fa ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Endoplasmic reticulum stress; Manganese; Neurotoxicity

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; ACTIVATING TRANSCRIPTION FACTOR 6; CASPASE 12; GLUCOSE REGULATED PROTEIN 78; INITIATION FACTOR 2ALPHA; LACTATE DEHYDROGENASE; MANGANESE; MESSENGER RNA; PERK PROTEIN; PROTEIN IRE1; PROTEIN P90; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; BRAIN CELL CULTURE; BRAIN SLICE; CELL DEATH; CONTROLLED STUDY; CULTURE MEDIUM; ENDOPLASMIC RETICULUM STRESS; GENE EXPRESSION; MOUSE; NERVE CELL LESION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RNA SPLICING; SIGNAL TRANSDUCTION; UPREGULATION;

Α SUBUNIT OF EUKARYOTIC TRANSLATION INITIATION FACTOR 2; 78-KDA GLUCOSE-REGULATED PROTEIN; 94-KDA GLUCOSE-REGULATED PROTEIN; ACTIVATING TRANSCRIPTION FACTOR 6; ANOVA; APOPTOSIS; ATF6; C/EBP HOMOLOGOUS PROTEIN; CHOP; EIF2Α; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; ER; GRP78; GRP94; HANK'S BALANCED SALT SOLUTION; HBSS; INOSITOL-REQUIRING ENZYME 1; IRE1; LACTATE DEHYDROGENASE; LDH; MANGANESE; METHYLCYCLOPENTADIENYL MN TRICARBONYL; MMT; MN; NEUROTOXICITY; ONE-WAY ANALYSIS OF VARIANCE; PANCREATIC ER KINASE RNA (PKR) LIKE ER KINASE; PERK; PI; PROPIDIUMIODIDE; UNFOLDED PROTEIN RESPONSE; UPR;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; BRAIN; DOSE-RESPONSE RELATIONSHIP, DRUG; EIF-2 KINASE; ENDOPLASMIC RETICULUM; HEAT-SHOCK PROTEINS; L-LACTATE DEHYDROGENASE; MANGANESE; MEMBRANE GLYCOPROTEINS; NEURONS; RATS; RATS, WISTAR; REAL-TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STRESS, PHYSIOLOGICAL; TISSUE CULTURE TECHNIQUES;

EID: 84883621413     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2013.08.001     Document Type: Article

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