All-trans-retinoic acid induces short forelimb malformation during mouse embryo development by inhibiting chondrocyte maturation rather than by evoking excess cell death

Toxicology Letters

Volumn 211, Issue 2, 2012, Pages 172-186

  Zhu, Yongfei ^a,b   Zhu, Yuping ^b   Yin, Hongping ^c   Zhou, Hongyuan ^b   Wan, Xuying ^b   Zhu, Jiangbo ^b   Zhang, Tianbao ^b  

^a HUNAN NORMAL UNIVERSITY   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

^c HANGZHOU NORMAL UNIVERSITY   (China)

Author keywords

All trans retinoic acid; Cyclins; Short forelimbs; Unfolded protein response

Indexed keywords

RETINOIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARTILAGE CELL; CELL DEATH; CELL DIFFERENTIATION; CELL MATURATION; CELL PROLIFERATION; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; FEMALE; GENE EXPRESSION; LIMB MALFORMATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SHORT FORELIMB MALFORMATION; UNFOLDED PROTEIN RESPONSE;

ABNORMALITIES, DRUG-INDUCED; ANIMALS; BLOTTING, WESTERN; CELL SURVIVAL; CHONDROCYTES; CYCLIN A1; CYCLIN B1; EMBRYONIC DEVELOPMENT; ENDOPLASMIC RETICULUM; FEMALE; FORELIMB; HISTOCYTOCHEMISTRY; MICE; MICE, INBRED ICR; PREGNANCY; RANDOM ALLOCATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRETINOIN; UNFOLDED PROTEIN RESPONSE;

EID: 84859931922     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2012.03.801     Document Type: Article

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