Sodium tauroursodeoxycholate prevents paraquat-induced cell death by suppressing endoplasmic reticulum stress responses in human lung epithelial A549 cells

Biochemical and Biophysical Research Communications

Volumn 432, Issue 4, 2013, Pages 689-694

  Omura, Tomohiro ^a   Asari, Masaru ^b   Yamamoto, Joe ^b   Oka, Kumiko ^b   Hoshina, Chisato ^b   Maseda, Chikatoshi ^b   Awaya, Toshio ^b   Tasaki, Yoshikazu ^b   Shiono, Hiroshi ^b   Yonezawa, Atsushi ^a   Masuda, Satohiro ^a   Matsubara, Kazuo ^a   Shimizu, Keiko ^b  

^a KYOTO UNIVERSITY HOSPITAL   (Japan)

^b ASAHIKAWA MEDICAL COLLEGE   (Japan)

Author keywords

Chemical chaperone; Endoplasmic reticulum stress (ERS); Paraquat; Sodium tauroursodeoxycholate (TUDCA); Unfolded protein response (UPR)

Indexed keywords

ANTITOXIN; CHAPERONE; DEOXYCHOLIC ACID; PARAQUAT; SODIUM TAUROURSODEOXYCHOLATE; UNCLASSIFIED DRUG;

ARTICLE; CELL DEATH; DEATH; ENDOPLASMIC RETICULUM STRESS; HUMAN; HUMAN CELL; INTOXICATION; LUNG ALVEOLUS EPITHELIUM; LUNG FIBROSIS; PRIORITY JOURNAL; UNFOLDED PROTEIN RESPONSE;

APOPTOSIS; CASPASE 3; CELL LINE; DNA-BINDING PROTEINS; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; EUKARYOTIC INITIATION FACTOR-2; HERBICIDES; HUMANS; LUNG; MITOCHONDRIAL PROTON-TRANSLOCATING ATPASES; PARAQUAT; RESPIRATORY MUCOSA; TAUROCHENODEOXYCHOLIC ACID; TRANSCRIPTION FACTORS; UNFOLDED PROTEIN RESPONSE;

ANIMALIA; MAMMALIA;

EID: 84875551638     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.01.131     Document Type: Article

References (33)

1. Bismuth C., Garnier R., Baud F.J., Muszynski J., Keyes C. Paraquat poisoning. An overview of the current status. Drug Saf. 1990, 5:243-251.
2. Vale J.A., Meredith T.J., Buckley B.M. Paraquat poisoning: clinical features and immediate general management. Hum. Toxicol. 1987, 6:41-47.
3. Suntres Z.E. Role of antioxidants in paraquat toxicity. Toxicology 2002, 180:65-77.
4. Onyeama H.P., Oehme F.W. A literature review of paraquat toxicity. Vet. Hum. Toxicol. 1984, 26:494-502.
5. Cappelletti G., Maggioni M.G., Maci R. Apoptosis in human lung epithelial cells: triggering by paraquat and modulation by antioxidants. Cell Biol. Int. 1998, 22:671-678.
6. Kaufman R.J., Scheuner D., Schroder M., Shen X., Lee K., Liu C.Y., Arnold S.M. The unfolded protein response in nutrient sensing and differentiation. Nat. Rev. Mol. Cell Biol. 2002, 3:411-421.
7. Omura T., Kaneko M., Okuma Y., Orba Y., Nagashima K., Takahashi R., Fujitani N., Matsumura S., Hata A., Kubota K., Murahashi K., Uehara T., Nomura Y. A ubiquitin ligase HRD1 promotes the degradation of Pael receptor, a substrate of parkin. J. Neurochem. 2006, 99:1456-1469.
8. Nadav E., Shmueli A., Barr H., Gonen H., Ciechanover A., Reiss Y. A novel mammalian endoplasmic reticulum ubiquitin ligase homologous to the yeast Hrd1. Biochem. Biophys. Res. Commun. 2003, 303:91-97.
9. Allen J.R., Nguyen L.X., Sargent K.E., Lipson K.L., Hackett A., Urano F. High ER stress in beta-cells stimulates intracellular degradation of misfolded insulin. Biochem. Biophys. Res. Commun. 2004, 324:166-170.
10. Gao B., Lee S.M., Chen A., Zhang J., Zhang D.D., Kannan K., Ortmann R.A., Fang D. Synoviolin promotes IRE1 ubiquitination and degradation in synovial fibroblasts from mice with collagen-induced arthritis. EMBO Rep. 2008, 9:480-485.
11. Amano T., Yamasaki S., Yagishita N., Tsuchimochi K., Shin H., Kawahara K., Aratani S., Fujita H., Zhang L., Ikeda R., Fujii R., Miura N., Komiya S., Nishioka K., Maruyama I., Fukamizu A., Nakajima T. Synoviolin/Hrd1, an E3 ubiquitin ligase, as a novel pathogenic factor for arthropathy. Genes Dev. 2003, 17:2436-2449.
12. Ozcan U., Yilmaz E., Ozcan L., Furuhashi M., Vaillancourt E., Smith R.O., Gorgun C.Z., Hotamisligil G.S. Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science 2006, 313:1137-1140.
13. Seyhun E., Malo A., Schafer C., Moskaluk C.A., Hoffmann R.T., Goke B., Kubisch C.H. Tauroursodeoxycholic acid reduces endoplasmic reticulum stress, acinar cell damage, and systemic inflammation in acute pancreatitis. Am. J. Physiol. Gastrointest. Liver Physiol. 2011, 301:G773-782.
14. Kubota K., Niinuma Y., Kaneko M., Okuma Y., Sugai M., Omura T., Uesugi M., Uehara T., Hosoi T., Nomura Y. Suppressive effects of 4-phenylbutyrate on the aggregation of Pael receptors and endoplasmic reticulum stress. J. Neurochem. 2006, 97:1259-1268.
15. Harding H.P., Novoa I., Zhang Y., Zeng H., Wek R., Schapira M., Ron D. Regulated translation initiation controls stress-induced gene expression in mammalian cells. Mol. Cell 2000, 6:1099-1108.
16. Haze K., Yoshida H., Yanagi H., Yura T., Mori K. Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress. Mol. Biol. Cell 1999, 10:3787-3799.
17. Omura T., Asari M., Yamamoto J., Kamiyama N., Oka K., Hoshina C., Maseda C., Awaya T., Tasaki Y., Shiono H., Shimizu K., Matsubara K. HRD1 levels increased by zonisamide prevented cell death and caspase-3 activation caused by endoplasmic reticulum stress in SH-SY5Y cells. J. Mol. Neurosci. 2012, 46:527-535.
18. Liang G., Audas T.E., Li Y., Cockram G.P., Dean J.D., Martyn A.C., Kokame K., Lu R. Luman/CREB3 induces transcription of the endoplasmic reticulum (ER) stress response protein Herp through an ER stress response element. Mol. Cell. Biol. 2006, 26:7999-8010.
19. Hershko A., Ciechanover A. The ubiquitin system. Annu. Rev. Biochem. 1998, 67:425-479.
20. Ron D., Walter P. Signal integration in the endoplasmic reticulum unfolded protein response. Nat. Rev. Mol. Cell Biol. 2007, 8:519-529.
21. Kaneko M., Ishiguro M., Niinuma Y., Uesugi M., Nomura Y. Human HRD1 protects against ER stress-induced apoptosis through ER-associated degradation. FEBS Lett. 2002, 532:147-152.
22. Omura T., Kaneko M., Onoguchi M., Koizumi S., Itami M., Ueyama M., Okuma Y., Nomura Y. Novel functions of ubiquitin ligase HRD1 with transmembrane and proline-rich domains. J. Pharmacol. Sci. 2008, 106:512-519.
23. Iida Y., Fujimori T., Okawa K., Nagata K., Wada I., Hosokawa N. SEL1L protein critically determines the stability of the HRD1-SEL1L endoplasmic reticulum-associated degradation (ERAD) complex to optimize the degradation kinetics of ERAD substrates. J. Biol. Chem. 2011, 286:16929-16939.
24. Mueller B., Lilley B.N., Ploegh H.L. SEL1L, the homologue of yeast Hrd3p, is involved in protein dislocation from the mammalian ER. J. Cell Biol. 2006, 175:261-270.
25. Kaneko M., Yasui S., Niinuma Y., Arai K., Omura T., Okuma Y., Nomura Y. A different pathway in the endoplasmic reticulum stress-induced expression of human HRD1 and SEL1 genes. FEBS Lett. 2007, 581:5355-5360.
26. Meusser B., Hirsch C., Jarosch E., Sommer T. ERAD: the long road to destruction. Nat. Cell Biol. 2005, 7:766-772.
27. Zerin T., Kim Y.S., Hong S.Y., Song H.Y. Protective effect of methylprednisolone on paraquat-induced A549 cell cytotoxicity via induction of efflux transporter P-glycoprotein expression. Toxicol. Lett. 2012, 208:101-107.
28. Mitsopoulos P., Suntres Z.E. Cytotoxicity and gene array analysis of alveolar epithelial A549 cells exposed to paraquat. Chem. Biol. Interact. 2010, 188:427-436.
29. Tomita M., Okuyama T., Ishikawa T., Hidaka K., Nohno T. The role of nitric oxide in paraquat-induced cytotoxicity in the human A549 lung carcinoma cell line. Free Radic. Res. 2001, 34:193-202.
30. Marciniak S.J., Yun C.Y., Oyadomari S., Novoa I., Zhang Y., Jungreis R., Nagata K., Harding H.P., Ron D. CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum. Genes Dev. 2004, 18:3066-3077.
31. Goldberg M.S., Fleming S.M., Palacino J.J., Cepeda C., Lam H.A., Bhatnagar A., Meloni E.G., Wu N., Ackerson L.C., Klapstein G.J., Gajendiran M., Roth B.L., Chesselet M.F., Maidment N.T., Levine M.S., Shen J. Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons. J. Biol. Chem. 2003, 278:43628-43635.
32. Ge Z.D., Ionova I.A., Vladic N., Pravdic D., Hirata N., Vasquez-Vivar J., Pratt P.F., Warltier D.C., Pieper G.M., Kersten J.R. Cardiac-specific overexpression of GTP cyclohydrolase 1 restores ischaemic preconditioning during hyperglycaemia. Cardiovasc. Res. 2011, 91:340-349.
33. Qi X., Hosoi T., Okuma Y., Kaneko M., Nomura Y. Sodium 4-phenylbutyrate protects against cerebral ischemic injury. Mol. Pharmacol. 2004, 66:899-908.