메뉴 건너뛰기




Volumn 15, Issue 4, 2015, Pages 225-237

Caveolae and signalling in cancer

Author keywords

[No Author keywords available]

Indexed keywords

CAVEOLIN 1; CAVEOLIN 2; CAVEOLIN 3; CD36 ANTIGEN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; TRANSFORMING GROWTH FACTOR BETA;

EID: 84925679239     PISSN: 1474175X     EISSN: 14741768     Source Type: Journal    
DOI: 10.1038/nrc3915     Document Type: Review
Times cited : (174)

References (183)
  • 1
    • 0015514472 scopus 로고
    • Thefluid mosaic model of the structure of cell membranes
    • Singer, S. J. & Nicolson, G. L. The fluid mosaic model of the structure of cell membranes. Science 175, 720-731 (1972).
    • (1972) Science , vol.175 , pp. 720-731
    • Singer, S.J.1    Nicolson, G.L.2
  • 2
    • 74849118341 scopus 로고    scopus 로고
    • Lipidrafts as a membrane-organizing principle
    • Lingwood, D. & Simons, K. Lipid rafts as a membrane-organizing principle. Science 327, 46-50 (2010).
    • (2010) Science , vol.327 , pp. 46-50
    • Lingwood, D.1    Simons, K.2
  • 3
    • 0032535156 scopus 로고    scopus 로고
    • Sphingomyelinase induces lipid microdomain formation in a fluid phosphatidylcholine/sphingomyelin membrane
    • Holopainen, J. M., Subramanian, M. & Kinnunen, P. K. Sphingomyelinase induces lipid microdomain formation in a fluid phosphatidylcholine/sphingomyelin membrane. Biochemistry 37, 17562-17570 (1998).
    • (1998) Biochemistry , vol.37 , pp. 17562-17570
    • Holopainen, J.M.1    Subramanian, M.2    Kinnunen, P.K.3
  • 4
    • 12244270658 scopus 로고    scopus 로고
    • Organizationin lipid membranes containing cholesterol
    • Veatch, S. L. & Keller, S. L. Organization in lipid membranes containing cholesterol. Phys. Rev. Lett. 89, 268101 (2002).
    • (2002) Phys. Rev. Lett. , vol.89 , pp. 268101
    • Veatch, S.L.1    Keller, S.L.2
  • 5
    • 0026559095 scopus 로고
    • Caveolin, a protein component of caveolae membrane coats
    • Rothberg, K. G. et al. Caveolin, a protein component of caveolae membrane coats. Cell 68, 673-682 (1992).
    • (1992) Cell , vol.68 , pp. 673-682
    • Rothberg, K.G.1
  • 6
    • 0030949124 scopus 로고    scopus 로고
    • Functionalrafts in cell membranes
    • Simons, K. & Ikonen, E. Functional rafts in cell membranes. Nature 387, 569-572 (1997).
    • (1997) Nature , vol.387 , pp. 569-572
    • Simons, K.1    Ikonen, E.2
  • 8
    • 33746085241 scopus 로고    scopus 로고
    • Raftsdefined: A report on the keystone symposium on lipid rafts and cell function
    • Pike, L. J. Rafts defined: a report on the Keystone Symposium on lipid rafts and cell function. J. Lipid Res. 47, 1597-1598 (2006).
    • (2006) J. Lipid Res. , vol.47 , pp. 1597-1598
    • Pike, L.J.1
  • 9
    • 84872959202 scopus 로고    scopus 로고
    • Caveolaeas plasma membrane sensors, protectors and organizers
    • Parton, R. G. & del Pozo, M. A. Caveolae as plasma membrane sensors, protectors and organizers. Nature Rev. Mol. Cell Biol. 14, 98-112 (2013).
    • (2013) Nature Rev. Mol. Cell Biol. , vol.14 , pp. 98-112
    • Parton, R.G.1    Del Pozo, M.A.2
  • 10
    • 72549086774 scopus 로고    scopus 로고
    • Thereggie/flotillin connection to growth
    • Stuermer, C. A. The reggie/flotillin connection to growth. Trends Cell Biol. 20, 6-13 (2010).
    • (2010) Trends Cell Biol. , vol.20 , pp. 6-13
    • Stuermer, C.A.1
  • 11
    • 0034625373 scopus 로고    scopus 로고
    • Structureand function of sphingolipid- and cholesterol-rich membrane rafts
    • Brown, D. A. & London, E. Structure and function of sphingolipid- and cholesterol-rich membrane rafts. J. Biol. Chem. 275, 17221-17224 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 17221-17224
    • Brown, D.A.1    London, E.2
  • 12
    • 0026512314 scopus 로고
    • Sortingof GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface
    • Brown, D. A. & Rose, J. K. Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface. Cell 68, 533-544 (1992).
    • (1992) Cell , vol.68 , pp. 533-544
    • Brown, D.A.1    Rose, J.K.2
  • 13
    • 0028285191 scopus 로고
    • Caveolae, caveolin and caveolin-rich membrane domains: A signalling hypothesis
    • Lisanti, M. P., Scherer, P. E., Tang, Z. & Sargiacomo, M. Caveolae, caveolin and caveolin-rich membrane domains: a signalling hypothesis. Trends Cell Biol. 4, 231-235 (1994).
    • (1994) Trends Cell Biol. , vol.4 , pp. 231-235
    • Lisanti, M.P.1    Scherer, P.E.2    Tang, Z.3    Sargiacomo, M.4
  • 14
    • 0029901663 scopus 로고    scopus 로고
    • Targetingof nitric oxide synthase to endothelial cell caveolae via palmitoylation: Implications for nitric oxide signaling
    • Garcia-Cardena, G., Oh, P., Liu, J., Schnitzer, J. E. & Sessa, W. C. Targeting of nitric oxide synthase to endothelial cell caveolae via palmitoylation: implications for nitric oxide signaling. Proc. Natl Acad. Sci. USA 93, 6448-6453 (1996).
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , pp. 6448-6453
    • Garcia-Cardena, G.1    Oh, P.2    Liu, J.3    Schnitzer, J.E.4    Sessa, W.C.5
  • 15
    • 0033604902 scopus 로고    scopus 로고
    • The dually acylated NH2 terminal domain of gi1α is sufficient to target a green fluorescent protein reporter to caveolin-enriched plasma membrane domains. Palmitoylation of caveolin-1 is required for the recognition of dually acylated g-protein α subunits in vivo
    • Galbiati, F. et al. The dually acylated NH2 terminal domain of gi1α is sufficient to target a green fluorescent protein reporter to caveolin-enriched plasma membrane domains. Palmitoylation of caveolin-1 is required for the recognition of dually acylated g-protein α subunits in vivo. J. Biol. Chem. 274, 5843-5850 (1999).
    • (1999) J. Biol. Chem. , vol.274 , pp. 5843-5850
    • Galbiati, F.1
  • 16
    • 0029809772 scopus 로고    scopus 로고
    • CD36 is palmitoylated on both N- and C-terminal cytoplasmic tails
    • Tao, N., Wagner, S. J. & Lublin, D. M. CD36 is palmitoylated on both N- and C-terminal cytoplasmic tails. J. Biol. Chem. 271, 22315-22320 (1996).
    • (1996) J. Biol. Chem. , vol.271 , pp. 22315-22320
    • Tao, N.1    Wagner, S.J.2    Lublin, D.M.3
  • 17
    • 0028920139 scopus 로고
    • Caveolinis palmitoylated on multiple cysteine residues. Palmitoylation is not necessary for localization of caveolin to caveolae
    • Dietzen, D. J., Hastings, W. R. & Lublin, D. M. Caveolin is palmitoylated on multiple cysteine residues. Palmitoylation is not necessary for localization of caveolin to caveolae. J. Biol. Chem. 270, 6838-6842 (1995).
    • (1995) J. Biol. Chem. , vol.270 , pp. 6838-6842
    • Dietzen, D.J.1    Hastings, W.R.2    Lublin, D.M.3
  • 18
    • 0000855817 scopus 로고
    • Finestructure of blood capillaries
    • Palade, G. E. Fine structure of blood capillaries. J. Appl. Phys. 24, 1424-1436 (1953).
    • (1953) J. Appl. Phys. , vol.24 , pp. 1424-1436
    • Palade, G.E.1
  • 19
    • 77049234363 scopus 로고
    • Thefine structure of the gall bladder epithelium of the mouse
    • Yamada, E. The fine structure of the gall bladder epithelium of the mouse. J. Biophys. Biochem. Cytol. 1, 445-458 (1955).
    • (1955) J. Biophys. Biochem. Cytol. , vol.1 , pp. 445-458
    • Yamada, E.1
  • 20
    • 0032489443 scopus 로고    scopus 로고
    • Caveolins, a family of scaffolding proteins for organizing "preassembled signaling complexes" at the plasma membrane
    • Okamoto, T., Schlegel, A., Scherer, P. E. & Lisanti, M. P. Caveolins, a family of scaffolding proteins for organizing "preassembled signaling complexes" at the plasma membrane. J. Biol. Chem. 273, 5419-5422 (1998).
    • (1998) J. Biol. Chem. , vol.273 , pp. 5419-5422
    • Okamoto, T.1    Schlegel, A.2    Scherer, P.E.3    Lisanti, M.P.4
  • 21
    • 84865169456 scopus 로고    scopus 로고
    • Thelipid raft hypothesis revisited-new insights on raft composition and function from super-resolution fluorescence microscopy
    • Owen, D. M., Magenau, A., Williamson, D. & Gaus, K. The lipid raft hypothesis revisited-new insights on raft composition and function from super-resolution fluorescence microscopy. Bioessays 34, 739-747 (2012).
    • (2012) Bioessays , vol.34 , pp. 739-747
    • Owen, D.M.1    Magenau, A.2    Williamson, D.3    Gaus, K.4
  • 22
    • 77950343947 scopus 로고    scopus 로고
    • The shape of caveolae is omega-like after glutaraldehyde fixation and cup-like after cryofixation
    • Schlormann, W. et al. The shape of caveolae is omega-like after glutaraldehyde fixation and cup-like after cryofixation. Histochem. Cell Biol. 133, 223-228 (2010).
    • (2010) Histochem. Cell Biol. , vol.133 , pp. 223-228
    • Schlormann, W.1
  • 23
    • 84855434874 scopus 로고    scopus 로고
    • Caveolin-1 and cancer metabolism in the tumor microenvironment: Markers, models, and mechanisms
    • Sotgia, F. et al. Caveolin-1 and cancer metabolism in the tumor microenvironment: markers, models, and mechanisms. Annu. Rev. Pathol. 7, 423-467 (2012).
    • (2012) Annu. Rev. Pathol. , vol.7 , pp. 423-467
    • Sotgia, F.1
  • 24
    • 34548150618 scopus 로고    scopus 로고
    • Regulationof raft-dependent endocytosis
    • Lajoie, P. & Nabi, I. R. Regulation of raft-dependent endocytosis. J. Cell. Mol. Med. 11, 644-653 (2007).
    • (2007) J. Cell. Mol. Med. , vol.11 , pp. 644-653
    • Lajoie, P.1    Nabi, I.R.2
  • 25
    • 0041969715 scopus 로고    scopus 로고
    • Differentialcaveolin-1 polarization in endothelial cells during migration in two and three dimensions
    • Parat, M. O., Anand-Apte, B. & Fox, P. L. Differential caveolin-1 polarization in endothelial cells during migration in two and three dimensions. Mol. Biol. Cell 14, 3156-3168 (2003).
    • (2003) Mol. Biol. Cell , vol.14 , pp. 3156-3168
    • Parat, M.O.1    Anand-Apte, B.2    Fox, P.L.3
  • 26
    • 0028885614 scopus 로고
    • VIP21/caveolin is a cholesterol-binding protein
    • Murata, M. et al. VIP21/caveolin is a cholesterol-binding protein. Proc. Natl Acad. Sci. USA 92, 10339-10343 (1995).
    • (1995) Proc. Natl Acad. Sci. USA , vol.92 , pp. 10339-10343
    • Murata, M.1
  • 27
    • 0029075988 scopus 로고
    • Oligomeric structure of caveolin: Implications for caveolae membrane organization
    • Sargiacomo, M. et al. Oligomeric structure of caveolin: implications for caveolae membrane organization. Proc. Natl Acad. Sci. USA 92, 9407-9411 (1995).
    • (1995) Proc. Natl Acad. Sci. USA , vol.92 , pp. 9407-9411
    • Sargiacomo, M.1
  • 28
    • 0030941001 scopus 로고    scopus 로고
    • Identificationof peptide and protein ligands for the caveolin-scaffolding domain. Implications for the interaction of caveolin with caveolae-associated proteins
    • Couet, J., Li, S., Okamoto, T., Ikezu, T. & Lisanti, M. P. Identification of peptide and protein ligands for the caveolin-scaffolding domain. Implications for the interaction of caveolin with caveolae-associated proteins. J. Biol. Chem. 272, 6525-6533 (1997).
    • (1997) J. Biol. Chem. , vol.272 , pp. 6525-6533
    • Couet, J.1    Li, S.2    Okamoto, T.3    Ikezu, T.4    Lisanti, M.P.5
  • 29
    • 0029803093 scopus 로고    scopus 로고
    • Srctyrosine kinases, Gα subunits, and H-Ras share a common membrane-anchored scaffolding protein, caveolin. Caveolin binding negatively regulates the auto-activation of Src tyrosine kinases
    • Li, S., Couet, J. & Lisanti, M. P. Src tyrosine kinases, Gα subunits, and H-Ras share a common membrane-anchored scaffolding protein, caveolin. Caveolin binding negatively regulates the auto-activation of Src tyrosine kinases. J. Biol. Chem. 271, 29182-29190 (1996).
    • (1996) J. Biol. Chem. , vol.271 , pp. 29182-29190
    • Li, S.1    Couet, J.2    Lisanti, M.P.3
  • 30
    • 0035964954 scopus 로고    scopus 로고
    • Loss of caveolae, vascular dysfunction, and pulmonary defects in caveolin-1 gene-disrupted mice
    • Drab, M. et al. Loss of caveolae, vascular dysfunction, and pulmonary defects in caveolin-1 gene-disrupted mice. Science 293, 2449-2452 (2001).
    • (2001) Science , vol.293 , pp. 2449-2452
    • Drab, M.1
  • 31
    • 0035851197 scopus 로고    scopus 로고
    • Caveolin-1 null mice are viable but show evidence of hyperproliferative and vascular abnormalities
    • Razani, B. et al. Caveolin-1 null mice are viable but show evidence of hyperproliferative and vascular abnormalities. J. Biol. Chem. 276, 38121-38138 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 38121-38138
    • Razani, B.1
  • 32
    • 0029086362 scopus 로고
    • Denovo formation of caveolae in lymphocytes by expression of VIP21-caveolin
    • Fra, A. M., Williamson, E., Simons, K. & Parton, R. G. De novo formation of caveolae in lymphocytes by expression of VIP21-caveolin. Proc. Natl Acad. Sci. USA 92, 8655-8659 (1995).
    • (1995) Proc. Natl Acad. Sci. USA , vol.92 , pp. 8655-8659
    • Fra, A.M.1    Williamson, E.2    Simons, K.3    Parton, R.G.4
  • 33
    • 0034914313 scopus 로고    scopus 로고
    • A 60-kDa protein abundant in adipocyte caveolae
    • Vinten, J. et al. A 60-kDa protein abundant in adipocyte caveolae. Cell Tissue Res. 305, 99-106 (2001).
    • (2001) Cell Tissue Res. , vol.305 , pp. 99-106
    • Vinten, J.1
  • 35
    • 37649011760 scopus 로고    scopus 로고
    • PTRF-Cavin, a conserved cytoplasmic protein required for caveola formation and function
    • Hill, M. M. et al. PTRF-Cavin, a conserved cytoplasmic protein required for caveola formation and function. Cell 132, 113-124 (2008).
    • (2008) Cell , vol.132 , pp. 113-124
    • Hill, M.M.1
  • 36
    • 67649583182 scopus 로고    scopus 로고
    • MURC/Cavin-4 and cavin family members form tissue-specific caveolar complexes
    • Bastiani, M. et al. MURC/Cavin-4 and cavin family members form tissue-specific caveolar complexes. J. Cell Biol. 185, 1259-1273 (2009).
    • (2009) J. Cell Biol. , vol.185 , pp. 1259-1273
    • Bastiani, M.1
  • 37
    • 79961113678 scopus 로고    scopus 로고
    • High-resolution mapping reveals topologically distinct cellular pools of phosphatidylserine
    • Fairn, G. D. et al. High-resolution mapping reveals topologically distinct cellular pools of phosphatidylserine. J. Cell Biol. 194, 257-275 (2011).
    • (2011) J. Cell Biol. , vol.194 , pp. 257-275
    • Fairn, G.D.1
  • 38
    • 84878592690 scopus 로고    scopus 로고
    • Deletionof cavin genes reveals tissue-specific mechanisms for morphogenesis of endothelial caveolae
    • Hansen, C. G., Shvets, E., Howard, G., Riento, K. & Nichols, B. J. Deletion of cavin genes reveals tissue-specific mechanisms for morphogenesis of endothelial caveolae. Nature Commun. 4, 1831 (2013).
    • (2013) Nature Commun. , vol.4 , pp. 1831
    • Hansen, C.G.1    Shvets, E.2    Howard, G.3    Riento, K.4    Nichols, B.J.5
  • 39
    • 77956097576 scopus 로고    scopus 로고
    • Congenital generalized lipodystrophy, type 4 (CGL4) associated with myopathy due to novel PTRF mutations
    • Shastry, S. et al. Congenital generalized lipodystrophy, type 4 (CGL4) associated with myopathy due to novel PTRF mutations. Am. J. Med. Genet. A 152A, 2245-2253 (2010).
    • (2010) Am. J. Med. Genet. A , vol.152 A , pp. 2245-2253
    • Shastry, S.1
  • 40
    • 77950431859 scopus 로고    scopus 로고
    • Fatal cardiac arrhythmia and long QT syndrome in a new form of congenital generalized lipodystrophy with muscle rippling (CGL4) due to PTRF-CAVIN mutations
    • Rajab, A. et al. Fatal cardiac arrhythmia and long QT syndrome in a new form of congenital generalized lipodystrophy with muscle rippling (CGL4) due to PTRF-CAVIN mutations. PLoS Genet. 6, e1000874 (2010).
    • (2010) PLoS Genet. , vol.6 , pp. e1000874
    • Rajab, A.1
  • 41
    • 84055177023 scopus 로고    scopus 로고
    • Down-regulation of the cavin family proteins in breast cancer
    • Bai, L. et al. Down-regulation of the cavin family proteins in breast cancer. J. Cell Biochem. 113, 322-328 (2012).
    • (2012) J. Cell Biochem. , vol.113 , pp. 322-328
    • Bai, L.1
  • 42
    • 30544454326 scopus 로고    scopus 로고
    • Expression of the candidate tumor suppressor gene hSRBC is frequently lost in primary lung cancers with and without DNA methylation
    • Zochbauer-Muller, S. et al. Expression of the candidate tumor suppressor gene hSRBC is frequently lost in primary lung cancers with and without DNA methylation. Oncogene 24, 6249-6255 (2005).
    • (2005) Oncogene , vol.24 , pp. 6249-6255
    • Zochbauer-Muller, S.1
  • 43
    • 0037705362 scopus 로고    scopus 로고
    • Immunopurification and characterization of rat adipocyte caveolae suggest their dissociation from insulin signaling
    • Souto, R. P. et al. Immunopurification and characterization of rat adipocyte caveolae suggest their dissociation from insulin signaling. J. Biol. Chem. 278, 18321-18329 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 18321-18329
    • Souto, R.P.1
  • 44
    • 35349007899 scopus 로고    scopus 로고
    • Architectural and mechanistic insights into an EHD ATPase involved in membrane remodelling
    • Daumke, O. et al. Architectural and mechanistic insights into an EHD ATPase involved in membrane remodelling. Nature 449, 923-927 (2007).
    • (2007) Nature , vol.449 , pp. 923-927
    • Daumke, O.1
  • 45
    • 84859396266 scopus 로고    scopus 로고
    • EHD2 regulates caveolar dynamics via ATP-driven targeting and oligomerization
    • Moren, B. et al. EHD2 regulates caveolar dynamics via ATP-driven targeting and oligomerization. Mol. Biol. Cell 23, 1316-1329 (2012).
    • (2012) Mol. Biol. Cell , vol.23 , pp. 1316-1329
    • Moren, B.1
  • 46
    • 79958105143 scopus 로고    scopus 로고
    • Essentialrole of PACSIN2/syndapin-II in caveolae membrane sculpting
    • Senju, Y., Itoh, Y., Takano, K., Hamada, S. & Suetsugu, S. Essential role of PACSIN2/syndapin-II in caveolae membrane sculpting. J. Cell Sci. 124, 2032-2040 (2011).
    • (2011) J. Cell Sci. , vol.124 , pp. 2032-2040
    • Senju, Y.1    Itoh, Y.2    Takano, K.3    Hamada, S.4    Suetsugu, S.5
  • 47
    • 79961145704 scopus 로고    scopus 로고
    • Pacsin2 is recruited to caveolae and functions in caveolar biogenesis
    • Hansen, C. G., Howard, G. & Nichols, B. J. Pacsin 2 is recruited to caveolae and functions in caveolar biogenesis. J. Cell Sci. 124, 2777-2785 (2011).
    • (2011) J. Cell Sci. , vol.124 , pp. 2777-2785
    • Hansen, C.G.1    Howard, G.2    Nichols, B.J.3
  • 48
    • 0031030664 scopus 로고    scopus 로고
    • Caveolin3 associates with developing T-tubules during muscle differentiation
    • Parton, R. G., Way, M., Zorzi, N. & Stang, E. Caveolin 3 associates with developing T-tubules during muscle differentiation. J. Cell Biol. 136, 137-154 (1997).
    • (1997) J. Cell Biol. , vol.136 , pp. 137-154
    • Parton, R.G.1    Way, M.2    Zorzi, N.3    Stang, E.4
  • 49
    • 0028138521 scopus 로고
    • Regulated internalization of caveolae
    • Parton, R. G., Joggerst, B. & Simons, K. Regulated internalization of caveolae. J. Cell Biol. 127, 1199-1215 (1994).
    • (1994) J. Cell Biol. , vol.127 , pp. 1199-1215
    • Parton, R.G.1    Joggerst, B.2    Simons, K.3
  • 51
    • 26944437142 scopus 로고    scopus 로고
    • Phospho-caveolin-1 mediates integrin-regulated membrane domain internalization
    • del Pozo, M. A. et al. Phospho-caveolin-1 mediates integrin-regulated membrane domain internalization. Nature Cell Biol. 7, 901-908 (2005).
    • (2005) Nature Cell Biol. , vol.7 , pp. 901-908
    • Del Pozo, M.A.1
  • 52
    • 0032516835 scopus 로고    scopus 로고
    • Cholesteroldepletion of caveolae causes hyperactivation of extracellular signal-related kinase (ERK)
    • Furuchi, T. & Anderson, R. G. Cholesterol depletion of caveolae causes hyperactivation of extracellular signal-related kinase (ERK). J. Biol. Chem. 273, 21099-21104 (1998).
    • (1998) J. Biol. Chem. , vol.273 , pp. 21099-21104
    • Furuchi, T.1    Anderson, R.G.2
  • 53
    • 0030970279 scopus 로고    scopus 로고
    • CaveolinmRNA levels are up-regulated by free cholesterol and down-regulated by oxysterols in fibroblast monolayers
    • Fielding, C. J., Bist, A. & Fielding, P. E. Caveolin mRNA levels are up-regulated by free cholesterol and down-regulated by oxysterols in fibroblast monolayers. Proc. Natl Acad. Sci. USA 94, 3753-3758 (1997).
    • (1997) Proc. Natl Acad. Sci. USA , vol.94 , pp. 3753-3758
    • Fielding, C.J.1    Bist, A.2    Fielding, P.E.3
  • 54
    • 0033559692 scopus 로고    scopus 로고
    • Hypercholesterolemia decreases nitric oxide production by promoting the interaction of caveolin and endothelial nitric oxide synthase
    • Feron, O., Dessy, C., Moniotte, S., Desager, J. P. & Balligand, J. L. Hypercholesterolemia decreases nitric oxide production by promoting the interaction of caveolin and endothelial nitric oxide synthase. J. Clin. Invest. 103, 897-905 (1999).
    • (1999) J. Clin. Invest. , vol.103 , pp. 897-905
    • Feron, O.1    Dessy, C.2    Moniotte, S.3    Desager, J.P.4    Balligand, J.L.5
  • 55
    • 33746855808 scopus 로고    scopus 로고
    • Caveolin-1 and regulation of cellular cholesterol homeostasis
    • Frank, P. G. et al. Caveolin-1 and regulation of cellular cholesterol homeostasis. Am. J. Physiol. Heart Circ. Physiol. 291, H677-H686 (2006).
    • (2006) Am. J. Physiol. Heart Circ. Physiol. , vol.291 , pp. H677-H686
    • Frank, P.G.1
  • 56
    • 79955471276 scopus 로고    scopus 로고
    • Caveolin-1 deficiency causes cholesterol-dependent mitochondrial dysfunction and apoptotic susceptibility
    • Bosch, M. et al. Caveolin-1 deficiency causes cholesterol-dependent mitochondrial dysfunction and apoptotic susceptibility. Curr. Biol. 21, 681-686 (2011).
    • (2011) Curr. Biol. , vol.21 , pp. 681-686
    • Bosch, M.1
  • 57
    • 84897544161 scopus 로고    scopus 로고
    • Cataboliccancer-associated fibroblasts transfer energy and biomass to anabolic cancer cells, fueling tumor growth
    • Martinez-Outschoorn, U. E., Lisanti, M. P. & Sotgia, F. Catabolic cancer-associated fibroblasts transfer energy and biomass to anabolic cancer cells, fueling tumor growth. Semin. Cancer Biol. 25, 47-60 (2014).
    • (2014) Semin. Cancer Biol. , vol.25 , pp. 47-60
    • Martinez-Outschoorn, U.E.1    Lisanti, M.P.2    Sotgia, F.3
  • 58
    • 66549114050 scopus 로고    scopus 로고
    • An absence of stromal caveolin-1 expression predicts early tumor recurrence and poor clinical outcome in human breast cancers
    • Witkiewicz, A. K. et al. An absence of stromal caveolin-1 expression predicts early tumor recurrence and poor clinical outcome in human breast cancers. Am. J. Pathol. 174, 2023-2034 (2009).
    • (2009) Am. J. Pathol. , vol.174 , pp. 2023-2034
    • Witkiewicz, A.K.1
  • 59
    • 66749106907 scopus 로고    scopus 로고
    • Stromal cell expression of caveolin 1 predicts outcome in breast cancer
    • Sloan, E. K. et al. Stromal cell expression of caveolin 1 predicts outcome in breast cancer. Am. J. Pathol. 174, 2035-2043 (2009).
    • (2009) Am. J. Pathol. , vol.174 , pp. 2035-2043
    • Sloan, E.K.1
  • 60
    • 84863724126 scopus 로고    scopus 로고
    • Clinicaland functional significance of loss of caveolin-1 expression in breast cancer-associated fibroblasts
    • Simpkins, S. A., Hanby, A. M., Holliday, D. L. & Speirs, V. Clinical and functional significance of loss of caveolin-1 expression in breast cancer-associated fibroblasts. J. Pathol. 227, 490-498 (2012).
    • (2012) J. Pathol. , vol.227 , pp. 490-498
    • Simpkins, S.A.1    Hanby, A.M.2    Holliday, D.L.3    Speirs, V.4
  • 61
    • 82855167795 scopus 로고    scopus 로고
    • Understanding the Warburg effect and the prognostic value of stromal caveolin-1 as a marker of a lethal tumor microenvironment
    • Sotgia, F. et al. Understanding the Warburg effect and the prognostic value of stromal caveolin-1 as a marker of a lethal tumor microenvironment. Breast Cancer Res. 13, 213 (2011).
    • (2011) Breast Cancer Res. , vol.13 , pp. 213
    • Sotgia, F.1
  • 62
    • 79951833645 scopus 로고    scopus 로고
    • Caveolin-1 and mitochondrial SOD2 (MnSOD) function as tumor suppressors in the stromal microenvironment: A new genetically tractable model for human cancer associated fibroblasts
    • Trimmer, C. et al. Caveolin-1 and mitochondrial SOD2 (MnSOD) function as tumor suppressors in the stromal microenvironment: a new genetically tractable model for human cancer associated fibroblasts. Cancer Biol. Ther. 11, 383-394 (2011).
    • (2011) Cancer Biol. Ther. , vol.11 , pp. 383-394
    • Trimmer, C.1
  • 63
    • 19944366937 scopus 로고    scopus 로고
    • Caveolin-1 gene disruption promotes mammary tumorigenesis and dramatically enhances lung metastasis in vivo. Role of Cav-1 in cell invasiveness and matrix metalloproteinase (MMP-2/9) secretion
    • Williams, T. M. et al. Caveolin-1 gene disruption promotes mammary tumorigenesis and dramatically enhances lung metastasis in vivo. Role of Cav-1 in cell invasiveness and matrix metalloproteinase (MMP-2/9) secretion. J. Biol. Chem. 279, 51630-51646 (2004).
    • (2004) J. Biol. Chem. , vol.279 , pp. 51630-51646
    • Williams, T.M.1
  • 64
    • 84858710602 scopus 로고    scopus 로고
    • Using the "reverse Warburg effect" to identify high-risk breast cancer patients: Stromal MCT4 predicts poor clinical outcome in triple-negative breast cancers
    • Witkiewicz, A. K. et al. Using the "reverse Warburg effect" to identify high-risk breast cancer patients: stromal MCT4 predicts poor clinical outcome in triple-negative breast cancers. Cell Cycle 11, 1108-1117 (2012).
    • (2012) Cell Cycle , vol.11 , pp. 1108-1117
    • Witkiewicz, A.K.1
  • 65
    • 79959947008 scopus 로고    scopus 로고
    • Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis
    • Goetz, J. G. et al. Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis. Cell 146, 148-163 (2011).
    • (2011) Cell , vol.146 , pp. 148-163
    • Goetz, J.G.1
  • 66
    • 84885179137 scopus 로고    scopus 로고
    • Loss of caveolin-1 in prostate cancer stroma correlates with reduced relapse-free survival and is functionally relevant to tumour progression
    • Ayala, G. et al. Loss of caveolin-1 in prostate cancer stroma correlates with reduced relapse-free survival and is functionally relevant to tumour progression. J. Pathol. 231, 77-87 (2013).
    • (2013) J. Pathol. , vol.231 , pp. 77-87
    • Ayala, G.1
  • 67
    • 84868380040 scopus 로고    scopus 로고
    • Themetabolic interactions between tumor cells and tumor-associated stroma (TAS) in prostatic cancer
    • Giatromanolaki, A., Koukourakis, M. I., Koutsopoulos, A., Mendrinos, S. & Sivridis, E. The metabolic interactions between tumor cells and tumor-associated stroma (TAS) in prostatic cancer. Cancer Biol. Ther. 13, 1284-1289 (2012).
    • (2012) Cancer Biol. Ther. , vol.13 , pp. 1284-1289
    • Giatromanolaki, A.1    Koukourakis, M.I.2    Koutsopoulos, A.3    Mendrinos, S.4    Sivridis, E.5
  • 68
    • 68449103256 scopus 로고    scopus 로고
    • An absence of stromal caveolin-1 is associated with advanced prostate cancer, metastatic disease and epithelial Akt activation
    • Di Vizio, D. et al. An absence of stromal caveolin-1 is associated with advanced prostate cancer, metastatic disease and epithelial Akt activation. Cell Cycle 8, 2420-2424 (2009).
    • (2009) Cell Cycle , vol.8 , pp. 2420-2424
    • Di Vizio, D.1
  • 69
    • 84891735192 scopus 로고    scopus 로고
    • Down-regulation of stromal caveolin 1 expression in esophageal squamous cell carcinoma: A potent predictor of lymph node metastases, early tumor recurrence, and poor prognosis
    • Jia, Y. et al. Down-regulation of stromal caveolin 1 expression in esophageal squamous cell carcinoma: a potent predictor of lymph node metastases, early tumor recurrence, and poor prognosis. Ann. Surg. Oncol. 21, 329-336 (2014).
    • (2014) Ann. Surg. Oncol. , vol.21 , pp. 329-336
    • Jia, Y.1
  • 70
    • 84875115414 scopus 로고    scopus 로고
    • Caveolin-1 expression level in cancer associated fibroblasts predicts outcome in gastric cancer
    • Zhao, X. et al. Caveolin-1 expression level in cancer associated fibroblasts predicts outcome in gastric cancer. PLoS ONE 8, e59102 (2013).
    • (2013) PLoS ONE , vol.8 , pp. e59102
    • Zhao, X.1
  • 71
    • 84055199763 scopus 로고    scopus 로고
    • Loss of stromal caveolin-1 expression in malignant melanoma metastases predicts poor survival
    • Wu, K. N. et al. Loss of stromal caveolin-1 expression in malignant melanoma metastases predicts poor survival. Cell Cycle 10, 4250-4255 (2011).
    • (2011) Cell Cycle , vol.10 , pp. 4250-4255
    • Wu, K.N.1
  • 72
    • 84922711587 scopus 로고    scopus 로고
    • Valueof caveolin-1 in cancer progression and prognosis: Emphasis on cancer-associated fibroblasts, human cancer cells and mechanism of caveolin-1 expression (Review)
    • Chen, D. & Che, G. Value of caveolin-1 in cancer progression and prognosis: Emphasis on cancer-associated fibroblasts, human cancer cells and mechanism of caveolin-1 expression (Review). Oncol. Lett. 8, 1409-1421 (2014).
    • (2014) Oncol. Lett. , vol.8 , pp. 1409-1421
    • Chen, D.1    Che, G.2
  • 73
    • 33846288318 scopus 로고    scopus 로고
    • Caveolin 1 is overexpressed and amplified in a subset of basal-like and metaplastic breast carcinomas: A morphologic, ultrastructural, immunohistochemical, and in situ hybridization analysis
    • Savage, K. et al. Caveolin 1 is overexpressed and amplified in a subset of basal-like and metaplastic breast carcinomas: a morphologic, ultrastructural, immunohistochemical, and in situ hybridization analysis. Clin. Cancer Res. 13, 90-101 (2007).
    • (2007) Clin. Cancer Res. , vol.13 , pp. 90-101
    • Savage, K.1
  • 74
    • 0033571471 scopus 로고    scopus 로고
    • Caveolin-1 expression in clinically confined human prostate cancer: A novel prognostic marker
    • Yang, G., Truong, L. D., Wheeler, T. M. & Thompson, T. C. Caveolin-1 expression in clinically confined human prostate cancer: a novel prognostic marker. Cancer Res. 59, 5719-5723 (1999).
    • (1999) Cancer Res. , vol.59 , pp. 5719-5723
    • Yang, G.1    Truong, L.D.2    Wheeler, T.M.3    Thompson, T.C.4
  • 75
    • 0032831879 scopus 로고    scopus 로고
    • Caveolin-1, a metastasis-related gene that promotes cell survival in prostate cancer
    • Thompson, T. C., Timme, T. L., Li, L. & Goltsov, A. Caveolin-1, a metastasis-related gene that promotes cell survival in prostate cancer. Apoptosis 4, 233-237 (1999).
    • (1999) Apoptosis , vol.4 , pp. 233-237
    • Thompson, T.C.1    Timme, T.L.2    Li, L.3    Goltsov, A.4
  • 76
    • 3042569629 scopus 로고    scopus 로고
    • Different roles for caveolin-1 in the development of non-small cell lung cancer versus small cell lung cancer
    • Sunaga, N. et al. Different roles for caveolin-1 in the development of non-small cell lung cancer versus small cell lung cancer. Cancer Res. 64, 4277-4285 (2004).
    • (2004) Cancer Res. , vol.64 , pp. 4277-4285
    • Sunaga, N.1
  • 77
    • 68549085187 scopus 로고    scopus 로고
    • Caveolin-1 tumor-promoting role in human melanoma
    • Felicetti, F. et al. Caveolin-1 tumor-promoting role in human melanoma. Int. J. Cancer 125, 1514-1522 (2009).
    • (2009) Int. J. Cancer , vol.125 , pp. 1514-1522
    • Felicetti, F.1
  • 78
    • 55949085790 scopus 로고    scopus 로고
    • Restoration of caveolin-1 expression suppresses growth and metastasis of head and neck squamous cell carcinoma
    • Zhang, H. et al. Restoration of caveolin-1 expression suppresses growth and metastasis of head and neck squamous cell carcinoma. Br. J. Cancer 99, 1684-1694 (2008).
    • (2008) Br. J. Cancer , vol.99 , pp. 1684-1694
    • Zhang, H.1
  • 79
    • 0038823763 scopus 로고    scopus 로고
    • Caveolin-I overexpression is a favourable prognostic factor for patients with extrahepatic bile duct carcinoma
    • Murakami, S. et al. Caveolin-I overexpression is a favourable prognostic factor for patients with extrahepatic bile duct carcinoma. Br. J. Cancer 88, 1234-1238 (2003).
    • (2003) Br. J. Cancer , vol.88 , pp. 1234-1238
    • Murakami, S.1
  • 80
    • 0034667394 scopus 로고    scopus 로고
    • Caveolin-1 levels are down-regulated in human colon tumors, and ectopic expression of caveolin-1 in colon carcinoma cell lines reduces cell tumorigenicity
    • Bender, F. C., Reymond, M. A., Bron, C. & Quest, A. F. Caveolin-1 levels are down-regulated in human colon tumors, and ectopic expression of caveolin-1 in colon carcinoma cell lines reduces cell tumorigenicity. Cancer Res. 60, 5870-5878 (2000).
    • (2000) Cancer Res. , vol.60 , pp. 5870-5878
    • Bender, F.C.1    Reymond, M.A.2    Bron, C.3    Quest, A.F.4
  • 81
    • 0035149144 scopus 로고    scopus 로고
    • Caveolin-1 is down-regulated in human ovarian carcinoma and acts as a candidate tumor suppressor gene
    • Wiechen, K. et al. Caveolin-1 is down-regulated in human ovarian carcinoma and acts as a candidate tumor suppressor gene. Am. J. Pathol. 159, 1635-1643 (2001).
    • (2001) Am. J. Pathol. , vol.159 , pp. 1635-1643
    • Wiechen, K.1
  • 82
    • 34047251876 scopus 로고    scopus 로고
    • Caveolin-1-deficient mice have increased tumor microvascular permeability, angiogenesis, and growth
    • Lin, M. I., Yu, J., Murata, T. & Sessa, W. C. Caveolin-1-deficient mice have increased tumor microvascular permeability, angiogenesis, and growth. Cancer Res. 67, 2849-2856 (2007).
    • (2007) Cancer Res. , vol.67 , pp. 2849-2856
    • Lin, M.I.1    Yu, J.2    Murata, T.3    Sessa, W.C.4
  • 83
    • 84884336745 scopus 로고    scopus 로고
    • Deficiency of caveolin-1 in Apcmin/+ mice promotes colorectal tumorigenesis
    • Friedrich, T. et al. Deficiency of caveolin-1 in Apcmin/+ mice promotes colorectal tumorigenesis. Carcinogenesis 34, 2109-2118 (2013).
    • (2013) Carcinogenesis , vol.34 , pp. 2109-2118
    • Friedrich, T.1
  • 84
    • 0038751964 scopus 로고    scopus 로고
    • Absence of caveolin-1 sensitizes mouse skin to carcinogen-induced epidermal hyperplasia and tumor formation
    • Capozza, F. et al. Absence of caveolin-1 sensitizes mouse skin to carcinogen-induced epidermal hyperplasia and tumor formation. Am. J. Pathol. 162, 2029-2039 (2003).
    • (2003) Am. J. Pathol. , vol.162 , pp. 2029-2039
    • Capozza, F.1
  • 85
    • 84860508683 scopus 로고    scopus 로고
    • Genetic ablation of Cav1 differentially affects melanoma tumor growth and metastasis in mice: Role of Cav1 in Shh heterotypic signaling and transendothelial migration
    • Capozza, F. et al. Genetic ablation of Cav1 differentially affects melanoma tumor growth and metastasis in mice: role of Cav1 in Shh heterotypic signaling and transendothelial migration. Cancer Res. 72, 2262-2274 (2012).
    • (2012) Cancer Res. , vol.72 , pp. 2262-2274
    • Capozza, F.1
  • 86
    • 84862646284 scopus 로고    scopus 로고
    • Caveolin-1 and accelerated host aging in the breast tumor microenvironment: Chemoprevention with rapamycin, an mTOR inhibitor and anti-aging drug
    • Mercier, I. et al. Caveolin-1 and accelerated host aging in the breast tumor microenvironment: chemoprevention with rapamycin, an mTOR inhibitor and anti-aging drug. Am. J. Pathol. 181, 278-293 (2012).
    • (2012) Am. J. Pathol. , vol.181 , pp. 278-293
    • Mercier, I.1
  • 87
    • 84906923001 scopus 로고    scopus 로고
    • PTRF/cavin-1 neutralizes non-caveolar caveolin-1 microdomains in prostate cancer
    • Moon, H. et al. PTRF/cavin-1 neutralizes non-caveolar caveolin-1 microdomains in prostate cancer. Oncogene 33, 3561-3570 (2013).
    • (2013) Oncogene , vol.33 , pp. 3561-3570
    • Moon, H.1
  • 88
    • 84866312491 scopus 로고    scopus 로고
    • CD36 repression activates a multicellular stromal program shared by high mammographic density and tumor tissues
    • DeFilippis, R. A. et al. CD36 repression activates a multicellular stromal program shared by high mammographic density and tumor tissues. Cancer Discov. 2, 826-839 (2012).
    • (2012) Cancer Discov. , vol.2 , pp. 826-839
    • Defilippis, R.A.1
  • 89
    • 0036786840 scopus 로고    scopus 로고
    • Stabilization of caveolin-1 by cellular cholesterol and scavenger receptor class B type I
    • Frank, P. G. et al. Stabilization of caveolin-1 by cellular cholesterol and scavenger receptor class B type I. Biochemistry 41, 11931-11940 (2002).
    • (2002) Biochemistry , vol.41 , pp. 11931-11940
    • Frank, P.G.1
  • 90
    • 0029910141 scopus 로고    scopus 로고
    • Endothelialnitric oxide synthase is regulated by tyrosine phosphorylation and interacts with caveolin 1
    • Garcia-Cardena, G., Fan, R., Stern, D. F., Liu, J. & Sessa, W. C. Endothelial nitric oxide synthase is regulated by tyrosine phosphorylation and interacts with caveolin 1. J. Biol. Chem. 271, 27237-27240 (1996).
    • (1996) J. Biol. Chem. , vol.271 , pp. 27237-27240
    • Garcia-Cardena, G.1    Fan, R.2    Stern, D.F.3    Liu, J.4    Sessa, W.C.5
  • 91
    • 0032538790 scopus 로고    scopus 로고
    • Targeted downregulation of caveolin-1 is sufficient to drive cell transformation and hyperactivate the p42/44 MAP kinase cascade
    • Galbiati, F. et al. Targeted downregulation of caveolin-1 is sufficient to drive cell transformation and hyperactivate the p42/44 MAP kinase cascade. EMBO J. 17, 6633-6648 (1998).
    • (1998) EMBO J. , vol.17 , pp. 6633-6648
    • Galbiati, F.1
  • 92
    • 0030731231 scopus 로고    scopus 로고
    • Interactionof a receptor tyrosine kinase, EGF-R, with caveolins. Caveolin binding negatively regulates tyrosine and serine/threonine kinase activities
    • Couet, J., Sargiacomo, M. & Lisanti, M. P. Interaction of a receptor tyrosine kinase, EGF-R, with caveolins. Caveolin binding negatively regulates tyrosine and serine/threonine kinase activities. J. Biol. Chem. 272, 30429-30438 (1997).
    • (1997) J. Biol. Chem. , vol.272 , pp. 30429-30438
    • Couet, J.1    Sargiacomo, M.2    Lisanti, M.P.3
  • 93
    • 0029912981 scopus 로고    scopus 로고
    • Co purification and direct interaction of Ras with caveolin, an integral membrane protein of caveolae microdomains. Detergent-free purification of caveolae microdomains
    • Song, K. S. et al. Co purification and direct interaction of Ras with caveolin, an integral membrane protein of caveolae microdomains. Detergent-free purification of caveolae microdomains. J. Biol. Chem. 271, 9690-9697 (1996).
    • (1996) J. Biol. Chem. , vol.271 , pp. 9690-9697
    • Song, K.S.1
  • 94
    • 0039397709 scopus 로고    scopus 로고
    • Dissecting the interaction between nitric oxide synthase (NOS) and caveolin. Functional significance of the nos caveolin binding domain in vivo
    • Garcia-Cardena, G. et al. Dissecting the interaction between nitric oxide synthase (NOS) and caveolin. Functional significance of the nos caveolin binding domain in vivo. J. Biol. Chem. 272, 25437-25440 (1997).
    • (1997) J. Biol. Chem. , vol.272 , pp. 25437-25440
    • Garcia-Cardena, G.1
  • 95
    • 84895770533 scopus 로고    scopus 로고
    • Caveolae regulate the nanoscale organization of the plasma membrane to remotely control Ras signaling
    • Ariotti, N. et al. Caveolae regulate the nanoscale organization of the plasma membrane to remotely control Ras signaling. J. Cell Biol. 204, 777-792 (2014).
    • (2014) J. Cell Biol. , vol.204 , pp. 777-792
    • Ariotti, N.1
  • 96
    • 0032546319 scopus 로고    scopus 로고
    • Tumorcell growth inhibition by caveolin re-expression in human breast cancer cells
    • Lee, S. W., Reimer, C. L., Oh, P., Campbell, D. B. & Schnitzer, J. E. Tumor cell growth inhibition by caveolin re-expression in human breast cancer cells. Oncogene 16, 1391-1397 (1998).
    • (1998) Oncogene , vol.16 , pp. 1391-1397
    • Lee, S.W.1    Reimer, C.L.2    Oh, P.3    Campbell, D.B.4    Schnitzer, J.E.5
  • 97
    • 0035158471 scopus 로고    scopus 로고
    • 1 arrest via a p53/p21(WAF1/Cip1)-dependent mechanism
    • 1 arrest via a p53/p21(WAF1/Cip1)-dependent mechanism. Mol. Biol. Cell 12, 2229-2244 (2001).
    • (2001) Mol. Biol. Cell , vol.12 , pp. 2229-2244
    • Galbiati, F.1
  • 98
    • 0034647728 scopus 로고    scopus 로고
    • The cyclin D1 gene is transcriptionally repressed by caveolin 1
    • Hulit, J. et al. The cyclin D1 gene is transcriptionally repressed by caveolin 1. J. Biol. Chem. 275, 21203-21209 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 21203-21209
    • Hulit, J.1
  • 99
    • 0028953271 scopus 로고
    • Reductionof caveolin and caveolae in oncogenically transformed cells
    • Koleske, A. J., Baltimore, D. & Lisanti, M. P. Reduction of caveolin and caveolae in oncogenically transformed cells. Proc. Natl Acad. Sci. USA 92, 1381-1385 (1995).
    • (1995) Proc. Natl Acad. Sci. USA , vol.92 , pp. 1381-1385
    • Koleske, A.J.1    Baltimore, D.2    Lisanti, M.P.3
  • 100
    • 0039252798 scopus 로고    scopus 로고
    • P42/44 MAP kinase-dependent and -independent signaling pathways regulate caveolin 1 gene expression. Activation of Ras-MAP kinase and protein kinase a signaling cascades transcriptionally down-regulates caveolin-1 promoter activity
    • Engelman, J. A., Zhang, X. L., Razani, B., Pestell, R. G. & Lisanti, M. P. p42/44 MAP kinase-dependent and -independent signaling pathways regulate caveolin 1 gene expression. Activation of Ras-MAP kinase and protein kinase a signaling cascades transcriptionally down-regulates caveolin-1 promoter activity. J. Biol. Chem. 274, 32333-32341 (1999).
    • (1999) J. Biol. Chem. , vol.274 , pp. 32333-32341
    • Engelman, J.A.1    Zhang, X.L.2    Razani, B.3    Pestell, R.G.4    Lisanti, M.P.5
  • 101
    • 84872166388 scopus 로고    scopus 로고
    • Divergentcontrol of Cav 1 expression in non-cancerous Li-Fraumeni syndrome and human cancer cell lines
    • Sherif, Z. A. & Sultan, A. S. Divergent control of Cav 1 expression in non-cancerous Li-Fraumeni syndrome and human cancer cell lines. Cancer Biol. Ther. 14, 29-38 (2013).
    • (2013) Cancer Biol. Ther. , vol.14 , pp. 29-38
    • Sherif, Z.A.1    Sultan, A.S.2
  • 102
    • 0035866759 scopus 로고    scopus 로고
    • Invasion activating caveolin 1 mutation in human scirrhous breast cancers
    • Hayashi, K. et al. Invasion activating caveolin 1 mutation in human scirrhous breast cancers. Cancer Res. 61, 2361-2364 (2001).
    • (2001) Cancer Res. , vol.61 , pp. 2361-2364
    • Hayashi, K.1
  • 103
    • 0036791604 scopus 로고    scopus 로고
    • -/- null mice show mammary epithelial cell hyperplasia
    • -/- null mice show mammary epithelial cell hyperplasia. Am. J. Pathol. 161, 1357-1369 (2002).
    • (2002) Am. J. Pathol. , vol.161 , pp. 1357-1369
    • Lee, H.1
  • 104
    • 65649133092 scopus 로고    scopus 로고
    • Caveolin-1 (P132L), a common breast cancer mutation, confers mammary cell invasiveness and defines a novel stem cell/metastasis-associated gene signature
    • Bonuccelli, G. et al. Caveolin-1 (P132L), a common breast cancer mutation, confers mammary cell invasiveness and defines a novel stem cell/metastasis-associated gene signature. Am. J. Pathol. 174, 1650-1662 (2009).
    • (2009) Am. J. Pathol. , vol.174 , pp. 1650-1662
    • Bonuccelli, G.1
  • 105
    • 84856220891 scopus 로고    scopus 로고
    • Non-existence of caveolin-1 gene mutations in human breast cancer
    • Patani, N. et al. Non-existence of caveolin-1 gene mutations in human breast cancer. Breast Cancer Res. Treat. 131, 307-310 (2012).
    • (2012) Breast Cancer Res. Treat. , vol.131 , pp. 307-310
    • Patani, N.1
  • 106
    • 54249141543 scopus 로고    scopus 로고
    • Phosphorylated caveolin-1 regulates Rho/ROCK-dependent focal adhesion dynamics and tumor cell migration and invasion
    • Joshi, B. et al. Phosphorylated caveolin-1 regulates Rho/ROCK-dependent focal adhesion dynamics and tumor cell migration and invasion. Cancer Res. 68, 8210-8220 (2008).
    • (2008) Cancer Res. , vol.68 , pp. 8210-8220
    • Joshi, B.1
  • 107
    • 79960882925 scopus 로고    scopus 로고
    • Redox-induced Src kinase and caveolin-1 signaling in TGFβ1 initiated SMAD2/3 activation and PAI-1 expression
    • Samarakoon, R. et al. Redox-induced Src kinase and caveolin-1 signaling in TGFβ1 initiated SMAD2/3 activation and PAI-1 expression. PLoS ONE 6, e22896 (2011).
    • (2011) PLoS ONE , vol.6 , pp. e22896
    • Samarakoon, R.1
  • 108
    • 0037089486 scopus 로고    scopus 로고
    • Cholesterol-rich lipid rafts mediate akt-regulated survival in prostate cancer cells
    • Zhuang, L., Lin, J., Lu, M. L., Solomon, K. R. & Freeman, M. R. Cholesterol-rich lipid rafts mediate akt-regulated survival in prostate cancer cells. Cancer Res. 62, 2227-2231 (2002).
    • (2002) Cancer Res. , vol.62 , pp. 2227-2231
    • Zhuang, L.1    Lin, J.2    Lu, M.L.3    Solomon, K.R.4    Freeman, M.R.5
  • 109
    • 77953188523 scopus 로고    scopus 로고
    • Pathologic caveolin-1 regulation of PTEN in idiopathic pulmonary fibrosis
    • Xia, H. et al. Pathologic caveolin-1 regulation of PTEN in idiopathic pulmonary fibrosis. Am. J. Pathol. 176, 2626-2637 (2010).
    • (2010) Am. J. Pathol. , vol.176 , pp. 2626-2637
    • Xia, H.1
  • 110
    • 70350510924 scopus 로고    scopus 로고
    • Pten in stromal fibroblasts suppresses mammary epithelial tumours
    • Trimboli, A. J. et al. Pten in stromal fibroblasts suppresses mammary epithelial tumours. Nature 461, 1084-1091 (2009).
    • (2009) Nature , vol.461 , pp. 1084-1091
    • Trimboli, A.J.1
  • 111
    • 1642512636 scopus 로고    scopus 로고
    • Synergy in tumor suppression by direct interaction of neutral endopeptidase with PTEN
    • Sumitomo, M. et al. Synergy in tumor suppression by direct interaction of neutral endopeptidase with PTEN. Cancer Cell 5, 67-78 (2004).
    • (2004) Cancer Cell , vol.5 , pp. 67-78
    • Sumitomo, M.1
  • 112
    • 84878262982 scopus 로고    scopus 로고
    • Transforming growth factor β1 (TGFβ1)-stimulated fibroblast to myofibroblast differentiation is mediated by hyaluronan (HA)-facilitated epidermal growth factor receptor (EGFR) and CD44 co-localization in lipid rafts
    • Midgley, A. C. et al. Transforming growth factor β1 (TGFβ1)-stimulated fibroblast to myofibroblast differentiation is mediated by hyaluronan (HA)-facilitated epidermal growth factor receptor (EGFR) and CD44 co-localization in lipid rafts. J. Biol. Chem. 288, 14824-14838 (2013).
    • (2013) J. Biol. Chem. , vol.288 , pp. 14824-14838
    • Midgley, A.C.1
  • 113
    • 84897556892 scopus 로고    scopus 로고
    • TGFβ in CAF-mediated tumor growth and metastasis
    • Calon, A., Tauriello, D. V. & Batlle, E. TGFβ in CAF-mediated tumor growth and metastasis. Semin. Cancer Biol. 25, 15-22 (2014).
    • (2014) Semin. Cancer Biol. , vol.25 , pp. 15-22
    • Calon, A.1    Tauriello, D.V.2    Batlle, E.3
  • 114
    • 78650563018 scopus 로고    scopus 로고
    • Autocrine TGFβ and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts
    • Kojima, Y. et al. Autocrine TGFβ and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts. Proc. Natl Acad. Sci. USA 107, 20009-20014 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 20009-20014
    • Kojima, Y.1
  • 115
    • 84865335195 scopus 로고    scopus 로고
    • Metabolic reprogramming of cancer-associated fibroblasts by TGFβ drives tumor growth: Connecting TGFβ signaling with "Warburg-like" cancer metabolism and L-lactate production
    • Guido, C. et al. Metabolic reprogramming of cancer-associated fibroblasts by TGFβ drives tumor growth: connecting TGFβ signaling with "Warburg-like" cancer metabolism and L-lactate production. Cell Cycle 11, 3019-3035 (2012).
    • (2012) Cell Cycle , vol.11 , pp. 3019-3035
    • Guido, C.1
  • 116
    • 2942614973 scopus 로고    scopus 로고
    • Elevated expression of TGFβ1 in head and neck cancer-associated fibroblasts
    • Rosenthal, E. et al. Elevated expression of TGFβ1 in head and neck cancer-associated fibroblasts. Mol. Carcinog. 40, 116-121 (2004).
    • (2004) Mol. Carcinog. , vol.40 , pp. 116-121
    • Rosenthal, E.1
  • 117
    • 84869021181 scopus 로고    scopus 로고
    • Dependency of colorectal cancer on a TGFβ-driven program in stromal cells for metastasis initiation
    • Calon, A. et al. Dependency of colorectal cancer on a TGFβ-driven program in stromal cells for metastasis initiation. Cancer Cell 22, 571-584 (2012).
    • (2012) Cancer Cell , vol.22 , pp. 571-584
    • Calon, A.1
  • 118
    • 84925663696 scopus 로고    scopus 로고
    • Silibinin prevents prostate cancer cell-mediated differentiation of naive fibroblasts into cancer-associated fibroblast phenotype by targeting TGF β2
    • Ting, H. J. et al. Silibinin prevents prostate cancer cell-mediated differentiation of naive fibroblasts into cancer-associated fibroblast phenotype by targeting TGF β2. Mol. Carcinog. http://dx.doi.org/10.1002/mc.22135 (2015).
    • (2015) Mol. Carcinog.
    • Ting, H.J.1
  • 119
    • 0035794218 scopus 로고    scopus 로고
    • Caveolin-1 regulates transforming growth factor TGFβ/SMAD signaling through an interaction with the TGFβ type I receptor
    • Razani, B. et al. Caveolin-1 regulates transforming growth factor TGFβ/SMAD signaling through an interaction with the TGFβ type I receptor. J. Biol. Chem. 276, 6727-6738 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 6727-6738
    • Razani, B.1
  • 120
    • 21044440756 scopus 로고    scopus 로고
    • Breast cancer cells induce stromal fibroblasts to express MMP9 via secretion of TNFα and TGFβ
    • Stuelten, C. H. et al. Breast cancer cells induce stromal fibroblasts to express MMP9 via secretion of TNFα and TGFβ. J. Cell Sci. 118, 2143-2153 (2005).
    • (2005) J. Cell Sci. , vol.118 , pp. 2143-2153
    • Stuelten, C.H.1
  • 121
    • 0034650486 scopus 로고    scopus 로고
    • Cellsurface-localized matrix metalloproteinase-9 proteolytically activates TGFβ and promotes tumor invasion and angiogenesis
    • Yu, Q. & Stamenkovic, I. Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGFβ and promotes tumor invasion and angiogenesis. Genes Dev. 14, 163-176 (2000).
    • (2000) Genes Dev. , vol.14 , pp. 163-176
    • Yu, Q.1    Stamenkovic, I.2
  • 122
    • 84861211257 scopus 로고    scopus 로고
    • A local paracrine and endocrine network involving TGFβ, Cox-2, ROS, and estrogen receptor β influences reactive stromal cell regulation of prostate cancer cell motility
    • Grubisha, M. J., Cifuentes, M. E., Hammes, S. R. & Defranco, D. B. A local paracrine and endocrine network involving TGFβ, Cox-2, ROS, and estrogen receptor β influences reactive stromal cell regulation of prostate cancer cell motility. Mol. Endocrinol. 26, 940-954 (2012).
    • (2012) Mol. Endocrinol. , vol.26 , pp. 940-954
    • Grubisha, M.J.1    Cifuentes, M.E.2    Hammes, S.R.3    Defranco, D.B.4
  • 123
    • 77954600493 scopus 로고    scopus 로고
    • Oxidative stress promotes myofibroblast differentiation and tumour spreading
    • Toullec, A. et al. Oxidative stress promotes myofibroblast differentiation and tumour spreading. EMBO Mol. Med. 2, 211-230 (2010).
    • (2010) EMBO Mol. Med. , vol.2 , pp. 211-230
    • Toullec, A.1
  • 124
    • 46649102319 scopus 로고    scopus 로고
    • Caveolin-1 up-regulation during epithelial to mesenchymal transition is mediated by focal adhesion kinase
    • Bailey, K. M. & Liu, J. Caveolin-1 up-regulation during epithelial to mesenchymal transition is mediated by focal adhesion kinase. J. Biol. Chem. 283, 13714-13724 (2008).
    • (2008) J. Biol. Chem. , vol.283 , pp. 13714-13724
    • Bailey, K.M.1    Liu, J.2
  • 125
    • 72449146370 scopus 로고    scopus 로고
    • Caveolin-1 promotes autoregulatory, Akt-mediated induction of cancer-promoting growth factors in prostate cancer cells
    • Li, L. et al. Caveolin-1 promotes autoregulatory, Akt-mediated induction of cancer-promoting growth factors in prostate cancer cells. Mol. Cancer Res. 7, 1781-1791 (2009).
    • (2009) Mol. Cancer Res. , vol.7 , pp. 1781-1791
    • Li, L.1
  • 126
    • 84874834152 scopus 로고    scopus 로고
    • Distinct dedifferentiation processes affect caveolin-1 expression in hepatocytes
    • Meyer, C. et al. Distinct dedifferentiation processes affect caveolin-1 expression in hepatocytes. Cell Commun. Signal 11, 6 (2013).
    • (2013) Cell Commun. Signal , vol.11 , pp. 6
    • Meyer, C.1
  • 127
    • 84863416895 scopus 로고    scopus 로고
    • Alteredmitochondrial function and metabolic inflexibility associated with loss of caveolin 1
    • Asterholm, I. W., Mundy, D. I., Weng, J., Anderson, R. G. & Scherer, P. E. Altered mitochondrial function and metabolic inflexibility associated with loss of caveolin 1. Cell. Metab. 15, 171-185 (2012).
    • (2012) Cell. Metab. , vol.15 , pp. 171-185
    • Asterholm, I.W.1    Mundy, D.I.2    Weng, J.3    Anderson, R.G.4    Scherer, P.E.5
  • 128
    • 77956400210 scopus 로고    scopus 로고
    • Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NFκB activation in the tumor stromal microenvironment
    • Martinez-Outschoorn, U. E. et al. Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NFκB activation in the tumor stromal microenvironment. Cell Cycle 9, 3515-3533 (2010).
    • (2010) Cell Cycle , vol.9 , pp. 3515-3533
    • Martinez-Outschoorn, U.E.1
  • 129
    • 77956399348 scopus 로고    scopus 로고
    • HIF1 α functions as a tumor promoter in cancer associated fibroblasts, and as a tumor suppressor in breast cancer cells: Autophagy drives compartment-specific oncogenesis
    • Chiavarina, B. et al. HIF1 α functions as a tumor promoter in cancer associated fibroblasts, and as a tumor suppressor in breast cancer cells: Autophagy drives compartment-specific oncogenesis. Cell Cycle 9, 3534-3551 (2010).
    • (2010) Cell Cycle , vol.9 , pp. 3534-3551
    • Chiavarina, B.1
  • 130
    • 0029664995 scopus 로고    scopus 로고
    • Acylation targets emdothelial nitric-oxide synthase to plasmalemmal caveolae
    • Shaul, P. W. et al. Acylation targets emdothelial nitric-oxide synthase to plasmalemmal caveolae. J. Biol. Chem. 271, 6518-6522 (1996).
    • (1996) J. Biol. Chem. , vol.271 , pp. 6518-6522
    • Shaul, P.W.1
  • 131
    • 0030853953 scopus 로고    scopus 로고
    • Directinteraction of endothelial nitric-oxide synthase and caveolin-1 inhibits synthase activity
    • Ju, H., Zou, R., Venema, V. J. & Venema, R. C. Direct interaction of endothelial nitric-oxide synthase and caveolin-1 inhibits synthase activity. J. Biol. Chem. 272, 18522-18525 (1997).
    • (1997) J. Biol. Chem. , vol.272 , pp. 18522-18525
    • Ju, H.1    Zou, R.2    Venema, V.J.3    Venema, R.C.4
  • 132
    • 16344373044 scopus 로고    scopus 로고
    • Antitumor effects of in vivo caveolin gene delivery are associated with the inhibition of the proangiogenic and vasodilatory effects of nitric oxide
    • Brouet, A. et al. Antitumor effects of in vivo caveolin gene delivery are associated with the inhibition of the proangiogenic and vasodilatory effects of nitric oxide. Faseb J. 19, 602-604 (2005).
    • (2005) Faseb J. , vol.19 , pp. 602-604
    • Brouet, A.1
  • 133
    • 84902194856 scopus 로고    scopus 로고
    • Cancer-associated fibroblasts expressing CXCL14 rely upon Nos1-derived nitric oxide signaling for their tumor supporting properties
    • Augsten, M. et al. Cancer-associated fibroblasts expressing CXCL14 rely upon Nos1-derived nitric oxide signaling for their tumor supporting properties. Cancer Res. 74, 2999-3010 (2014).
    • (2014) Cancer Res. , vol.74 , pp. 2999-3010
    • Augsten, M.1
  • 134
    • 0028145462 scopus 로고
    • Nitricoxide-mediated inhibition of the mitochondrial respiratory chain in cultured astrocytes
    • Bolanos, J. P., Peuchen, S., Heales, S. J., Land, J. M. & Clark, J. B. Nitric oxide-mediated inhibition of the mitochondrial respiratory chain in cultured astrocytes. J. Neurochem. 63, 910-916 (1994).
    • (1994) J. Neurochem. , vol.63 , pp. 910-916
    • Bolanos, J.P.1    Peuchen, S.2    Heales, S.J.3    Land, J.M.4    Clark, J.B.5
  • 135
    • 0035477926 scopus 로고    scopus 로고
    • Nitric oxide inhibits mitochondrial NADH: Ubiquinone reductase activity through peroxynitrite formation
    • Riobo, N. A. et al. Nitric oxide inhibits mitochondrial NADH:ubiquinone reductase activity through peroxynitrite formation. Biochem. J. 359, 139-145 (2001).
    • (2001) Biochem. J. , vol.359 , pp. 139-145
    • Riobo, N.A.1
  • 136
    • 0036513249 scopus 로고    scopus 로고
    • Doesnitric oxide modulate mitochondrial energy generation and apoptosis?
    • Moncada, S. & Erusalimsky, J. D. Does nitric oxide modulate mitochondrial energy generation and apoptosis? Nature Rev. Mol. Cell Biol. 3, 214-220 (2002).
    • (2002) Nature Rev. Mol. Cell Biol. , vol.3 , pp. 214-220
    • Moncada, S.1    Erusalimsky, J.D.2
  • 137
    • 7944232052 scopus 로고    scopus 로고
    • Nitricoxide induces coupling of mitochondrial signalling with the endoplasmic reticulum stress response
    • Xu, W., Liu, L., Charles, I. G. & Moncada, S. Nitric oxide induces coupling of mitochondrial signalling with the endoplasmic reticulum stress response. Nature Cell Biol. 6, 1129-1134 (2004).
    • (2004) Nature Cell Biol. , vol.6 , pp. 1129-1134
    • Xu, W.1    Liu, L.2    Charles, I.G.3    Moncada, S.4
  • 138
    • 38049136885 scopus 로고    scopus 로고
    • S-nitrosation of mitochondrial complex I depends on its structural conformation
    • Galkin, A. & Moncada, S. S-nitrosation of mitochondrial complex I depends on its structural conformation. J. Biol. Chem. 282, 37448-37453 (2007).
    • (2007) J. Biol. Chem. , vol.282 , pp. 37448-37453
    • Galkin, A.1    Moncada, S.2
  • 139
    • 0033538644 scopus 로고    scopus 로고
    • Opposing effects of reactive oxygen species and cholesterol on endothelial nitric oxide synthase and endothelial cell caveolae
    • Peterson, T. E. et al. Opposing effects of reactive oxygen species and cholesterol on endothelial nitric oxide synthase and endothelial cell caveolae. Circ. Res. 85, 29-37 (1999).
    • (1999) Circ. Res. , vol.85 , pp. 29-37
    • Peterson, T.E.1
  • 140
    • 0036471359 scopus 로고    scopus 로고
    • Oxidativestress inhibits caveolin-1 palmitoylation and trafficking in endothelial cells
    • Parat, M. O., Stachowicz, R. Z. & Fox, P. L. Oxidative stress inhibits caveolin-1 palmitoylation and trafficking in endothelial cells. Biochem. J. 361, 681-688 (2002).
    • (2002) Biochem. J. , vol.361 , pp. 681-688
    • Parat, M.O.1    Stachowicz, R.Z.2    Fox, P.L.3
  • 141
    • 79957922046 scopus 로고    scopus 로고
    • Evidence for a stromal-epithelial "lactate shuttle" in human tumors: MCT4 is a marker of oxidative stress in cancer-associated fibroblasts
    • Whitaker-Menezes, D. et al. Evidence for a stromal-epithelial "lactate shuttle" in human tumors: MCT4 is a marker of oxidative stress in cancer-associated fibroblasts. Cell Cycle 10, 1772-1783 (2011).
    • (2011) Cell Cycle , vol.10 , pp. 1772-1783
    • Whitaker-Menezes, D.1
  • 142
    • 82855182002 scopus 로고    scopus 로고
    • Hyperactivation of oxidative mitochondrial metabolism in epithelial cancer cells in situ: Visualizing the therapeutic effects of metformin in tumor tissue
    • Whitaker-Menezes, D. et al. Hyperactivation of oxidative mitochondrial metabolism in epithelial cancer cells in situ: visualizing the therapeutic effects of metformin in tumor tissue. Cell Cycle 10, 4047-4064 (2011).
    • (2011) Cell Cycle , vol.10 , pp. 4047-4064
    • Whitaker-Menezes, D.1
  • 143
    • 76349096670 scopus 로고    scopus 로고
    • Cancer-associated fibroblasts are activated in incipient neoplasia to orchestrate tumor-promoting inflammation in an NF κb-dependent manner
    • Erez, N., Truitt, M., Olson, P., Arron, S. T. & Hanahan, D. Cancer-associated fibroblasts are activated in incipient neoplasia to orchestrate tumor-promoting inflammation in an NF κB-dependent manner. Cancer Cell 17, 135-147 (2010).
    • (2010) Cancer Cell , vol.17 , pp. 135-147
    • Erez, N.1    Truitt, M.2    Olson, P.3    Arron, S.T.4    Hanahan, D.5
  • 144
    • 44849100198 scopus 로고    scopus 로고
    • NF κb links innate immunity to the hypoxic response through transcriptional regulation of HIF 1α
    • Rius, J. et al. NF κB links innate immunity to the hypoxic response through transcriptional regulation of HIF 1α. Nature 453, 807-811 (2008).
    • (2008) Nature , vol.453 , pp. 807-811
    • Rius, J.1
  • 145
    • 84880765111 scopus 로고    scopus 로고
    • Cancer-associated fibroblasts promote proliferation of endometrial cancer cells
    • Subramaniam, K. S. et al. Cancer-associated fibroblasts promote proliferation of endometrial cancer cells. PLoS ONE 8, e68923 (2013).
    • (2013) PLoS ONE , vol.8 , pp. e68923
    • Subramaniam, K.S.1
  • 146
    • 84869219069 scopus 로고    scopus 로고
    • Cross-species functional analysis of cancer-associated fibroblasts identifies a critical role for CLCF1 and IL-6 in non-small cell lung cancer in vivo
    • Vicent, S. et al. Cross-species functional analysis of cancer-associated fibroblasts identifies a critical role for CLCF1 and IL-6 in non-small cell lung cancer in vivo. Cancer Res. 72, 5744-5756 (2012).
    • (2012) Cancer Res. , vol.72 , pp. 5744-5756
    • Vicent, S.1
  • 147
    • 84880934991 scopus 로고    scopus 로고
    • Cancerassociated fibroblasts express pro-inflammatory factors in human breast and ovarian tumors
    • Erez, N., Glanz, S., Raz, Y., Avivi, C. & Barshack, I. Cancer associated fibroblasts express pro-inflammatory factors in human breast and ovarian tumors. Biochem. Biophys. Res. Commun. 437, 397-402 (2013).
    • (2013) Biochem. Biophys. Res. Commun. , vol.437 , pp. 397-402
    • Erez, N.1    Glanz, S.2    Raz, Y.3    Avivi, C.4    Barshack, I.5
  • 148
    • 79957902168 scopus 로고    scopus 로고
    • Cytokine production and inflammation drive autophagy in the tumor microenvironment: Role of stromal caveolin-1 as a key regulator
    • Martinez-Outschoorn, U. E. et al. Cytokine production and inflammation drive autophagy in the tumor microenvironment: role of stromal caveolin-1 as a key regulator. Cell Cycle 10, 1784-1793 (2011).
    • (2011) Cell Cycle , vol.10 , pp. 1784-1793
    • Martinez-Outschoorn, U.E.1
  • 149
    • 62549120295 scopus 로고    scopus 로고
    • -/- null mammary stromal fibroblasts share characteristics with human breast cancer-associated fibroblasts
    • -/- null mammary stromal fibroblasts share characteristics with human breast cancer-associated fibroblasts. Am. J. Pathol. 174, 746-761 (2009).
    • (2009) Am. J. Pathol. , vol.174 , pp. 746-761
    • Sotgia, F.1
  • 150
    • 9144229688 scopus 로고    scopus 로고
    • -/- mice show dramatic reductions in life span
    • -/- mice show dramatic reductions in life span. Biochemistry 42, 15124-15131 (2003).
    • (2003) Biochemistry , vol.42 , pp. 15124-15131
    • Park, D.S.1
  • 151
    • 77955876472 scopus 로고    scopus 로고
    • The lipoatrophic caveolin-1 deficient mouse model reveals autophagy in mature adipocytes
    • Le Lay, S. et al. The lipoatrophic caveolin-1 deficient mouse model reveals autophagy in mature adipocytes. Autophagy 6, 754-763 (2010).
    • (2010) Autophagy , vol.6 , pp. 754-763
    • Le Lay, S.1
  • 152
    • 84879323485 scopus 로고    scopus 로고
    • Metabolic alterations in lung cancer-associated fibroblasts correlated with increased glycolytic metabolism of the tumor
    • Chaudhri, V. K. et al. Metabolic alterations in lung cancer-associated fibroblasts correlated with increased glycolytic metabolism of the tumor. Mol. Cancer Res. 11, 579-592 (2013).
    • (2013) Mol. Cancer Res. , vol.11 , pp. 579-592
    • Chaudhri, V.K.1
  • 153
    • 33745885329 scopus 로고    scopus 로고
    • DRAM, a p53-induced modulator of autophagy, is critical for apoptosis
    • Crighton, D. et al. DRAM, a p53-induced modulator of autophagy, is critical for apoptosis. Cell 126,121-134 (2006).
    • (2006) Cell , vol.126 , pp. 121-134
    • Crighton, D.1
  • 154
    • 33750798741 scopus 로고    scopus 로고
    • The chemokine growth-regulated oncogene 1 (Gro-1) links RAS signaling to the senescence of stromal fibroblasts and ovarian tumorigenesis
    • Yang, G. et al. The chemokine growth-regulated oncogene 1 (Gro-1) links RAS signaling to the senescence of stromal fibroblasts and ovarian tumorigenesis. Proc. Natl Acad. Sci. USA 103, 16472-16477 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 16472-16477
    • Yang, G.1
  • 155
    • 13944270339 scopus 로고    scopus 로고
    • Senescentcells, tumor suppression, and organismal aging: Good citizens, bad neighbors
    • Campisi, J. Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell 120, 513-522 (2005).
    • (2005) Cell , vol.120 , pp. 513-522
    • Campisi, J.1
  • 156
    • 0035079864 scopus 로고    scopus 로고
    • Replicative senescence in normal liver, chronic hepatitis C, and hepatocellular carcinomas
    • Paradis, V. et al. Replicative senescence in normal liver, chronic hepatitis C, and hepatocellular carcinomas. Hum. Pathol. 32, 327-332 (2001).
    • (2001) Hum. Pathol. , vol.32 , pp. 327-332
    • Paradis, V.1
  • 157
    • 84868633053 scopus 로고    scopus 로고
    • Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance through WNT16B
    • Sun, Y. et al. Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance through WNT16B. Nature Med. 18, 1359-1368 (2012).
    • (2012) Nature Med. , vol.18 , pp. 1359-1368
    • Sun, Y.1
  • 158
    • 0035834121 scopus 로고    scopus 로고
    • Senescentfibroblasts promote epithelial cell growth and tumorigenesis: A link between cancer and aging
    • Krtolica, A., Parrinello, S., Lockett, S., Desprez, P. Y. & Campisi, J. Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging. Proc. Natl Acad. Sci. USA 98, 12072-12077 (2001).
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , pp. 12072-12077
    • Krtolica, A.1    Parrinello, S.2    Lockett, S.3    Desprez, P.Y.4    Campisi, J.5
  • 159
    • 31544479046 scopus 로고    scopus 로고
    • The gene expression program of prostate fibroblast senescence modulates neoplastic epithelial cell proliferation through paracrine mechanisms
    • Bavik, C. et al. The gene expression program of prostate fibroblast senescence modulates neoplastic epithelial cell proliferation through paracrine mechanisms. Cancer Res. 66, 794-802 (2006).
    • (2006) Cancer Res. , vol.66 , pp. 794-802
    • Bavik, C.1
  • 160
    • 0034663601 scopus 로고    scopus 로고
    • Thelow-affinity monocarboxylate transporter MCT4 is adapted to the export of lactate in highly glycolytic cells
    • Dimmer, K. S., Friedrich, B., Lang, F., Deitmer, J. W. & Broer, S. The low-affinity monocarboxylate transporter MCT4 is adapted to the export of lactate in highly glycolytic cells. Biochem. J. 350, 219-227 (2000).
    • (2000) Biochem. J. , vol.350 , pp. 219-227
    • Dimmer, K.S.1    Friedrich, B.2    Lang, F.3    Deitmer, J.W.4    Broer, S.5
  • 161
    • 33646917296 scopus 로고    scopus 로고
    • Theplasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF 1α dependent mechanism
    • Ullah, M. S., Davies, A. J. & Halestrap, A. P. The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF 1α dependent mechanism. J. Biol. Chem. 281, 9030-9037 (2006).
    • (2006) J. Biol. Chem. , vol.281 , pp. 9030-9037
    • Ullah, M.S.1    Davies, A.J.2    Halestrap, A.P.3
  • 162
    • 84883237456 scopus 로고    scopus 로고
    • Loss of caveolin-1 and gain of MCT4 expression in the tumor stroma: Key events in the progression from an in situ to an invasive breast carcinoma
    • Martins, D. et al. Loss of caveolin-1 and gain of MCT4 expression in the tumor stroma: key events in the progression from an in situ to an invasive breast carcinoma. Cell Cycle 12, 2684-2690 (2013).
    • (2013) Cell Cycle , vol.12 , pp. 2684-2690
    • Martins, D.1
  • 163
    • 84884286419 scopus 로고    scopus 로고
    • Progression from ductal carcinoma in situ to invasive breast cancer: Revisited
    • Cowell, C. F. et al. Progression from ductal carcinoma in situ to invasive breast cancer: revisited. Mol. Oncol. 7, 859-869 (2013).
    • (2013) Mol. Oncol. , vol.7 , pp. 859-869
    • Cowell, C.F.1
  • 164
    • 74849087878 scopus 로고    scopus 로고
    • The reverse Warburg effect: Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma
    • Pavlides, S. et al. The reverse Warburg effect: aerobic glycolysis in cancer associated fibroblasts and the tumor stroma. Cell Cycle 8, 3984-4001 (2009).
    • (2009) Cell Cycle , vol.8 , pp. 3984-4001
    • Pavlides, S.1
  • 165
    • 84896887907 scopus 로고    scopus 로고
    • Caveolin-1 is a critical determinant of autophagy, metabolic switching, and oxidative stress in vascular endothelium
    • Shiroto, T. et al. Caveolin-1 is a critical determinant of autophagy, metabolic switching, and oxidative stress in vascular endothelium. PLoS ONE 9, e87871 (2014).
    • (2014) PLoS ONE , vol.9 , pp. e87871
    • Shiroto, T.1
  • 166
    • 84869467226 scopus 로고    scopus 로고
    • Ketone bodies and two-compartment tumor metabolism: Stromal ketone production fuels mitochondrial biogenesis in epithelial cancer cells
    • Martinez-Outschoorn, U. E. et al. Ketone bodies and two-compartment tumor metabolism: stromal ketone production fuels mitochondrial biogenesis in epithelial cancer cells. Cell Cycle 11, 3956-3963 (2012).
    • (2012) Cell Cycle , vol.11 , pp. 3956-3963
    • Martinez-Outschoorn, U.E.1
  • 167
    • 84867112200 scopus 로고    scopus 로고
    • Reciprocal metabolic reprogramming through lactate shuttle coordinately influences tumor-stroma interplay
    • Fiaschi, T. et al. Reciprocal metabolic reprogramming through lactate shuttle coordinately influences tumor-stroma interplay. Cancer Res. 72, 5130-5140 (2012).
    • (2012) Cancer Res. , vol.72 , pp. 5130-5140
    • Fiaschi, T.1
  • 168
    • 84873390490 scopus 로고    scopus 로고
    • Impact of tumor microenvironment and epithelial phenotypes on metabolism in breast cancer
    • Brauer, H. A. et al. Impact of tumor microenvironment and epithelial phenotypes on metabolism in breast cancer. Clin. Cancer Res. 19, 571-585 (2013).
    • (2013) Clin. Cancer Res. , vol.19 , pp. 571-585
    • Brauer, H.A.1
  • 169
    • 0031930319 scopus 로고    scopus 로고
    • Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice
    • Larsson, N. G. et al. Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice. Nature Genet. 18, 231-236 (1998).
    • (1998) Nature Genet. , vol.18 , pp. 231-236
    • Larsson, N.G.1
  • 170
    • 77956419439 scopus 로고    scopus 로고
    • Ketones and lactate "fuel" tumor growth and metastasis: Evidence that epithelial cancer cells use oxidative mitochondrial metabolism
    • Bonuccelli, G. et al. Ketones and lactate "fuel" tumor growth and metastasis: Evidence that epithelial cancer cells use oxidative mitochondrial metabolism. Cell Cycle 9, 3506-3514 (2010).
    • (2010) Cell Cycle , vol.9 , pp. 3506-3514
    • Bonuccelli, G.1
  • 171
    • 79953329777 scopus 로고    scopus 로고
    • Lactateinflux through the endothelial cell monocarboxylate transporter MCT1 supports an NF κb/IL-8 pathway that drives tumor angiogenesis
    • Vegran, F., Boidot, R., Michiels, C., Sonveaux, P. & Feron, O. Lactate influx through the endothelial cell monocarboxylate transporter MCT1 supports an NF κB/IL-8 pathway that drives tumor angiogenesis. Cancer Res. 71, 2550-2560 (2011).
    • (2011) Cancer Res. , vol.71 , pp. 2550-2560
    • Vegran, F.1    Boidot, R.2    Michiels, C.3    Sonveaux, P.4    Feron, O.5
  • 172
    • 17844383964 scopus 로고    scopus 로고
    • Perturbational profiling of a cell-line model of tumorigenesis by using metabolic measurements
    • Ramanathan, A., Wang, C. & Schreiber, S. L. Perturbational profiling of a cell-line model of tumorigenesis by using metabolic measurements. Proc. Natl Acad. Sci. USA 102, 5992-5997 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 5992-5997
    • Ramanathan, A.1    Wang, C.2    Schreiber, S.L.3
  • 173
    • 84055199818 scopus 로고    scopus 로고
    • Pyruvate kinase expression (PKM1 and PKM2) in cancer-associated fibroblasts drives stromal nutrient production and tumor growth
    • Chiavarina, B. et al. Pyruvate kinase expression (PKM1 and PKM2) in cancer-associated fibroblasts drives stromal nutrient production and tumor growth. Cancer Biol. Ther. 12, 1101-1113 (2011).
    • (2011) Cancer Biol. Ther. , vol.12 , pp. 1101-1113
    • Chiavarina, B.1
  • 174
    • 84896722500 scopus 로고    scopus 로고
    • Tumor-stroma metabolic relationship based on lactate shuttle can sustain prostate cancer progression
    • Sanita, P. et al. Tumor-stroma metabolic relationship based on lactate shuttle can sustain prostate cancer progression. BMC Cancer 14, 154 (2014).
    • (2014) BMC Cancer , vol.14 , pp. 154
    • Sanita, P.1
  • 175
    • 81255157465 scopus 로고    scopus 로고
    • Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth
    • Nieman, K. M. et al. Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth. Nature Med. 17, 1498-1503 (2011).
    • (2011) Nature Med. , vol.17 , pp. 1498-1503
    • Nieman, K.M.1
  • 176
    • 84891525398 scopus 로고    scopus 로고
    • Metabolicphenotypes in primary unknown metastatic carcinoma
    • Kim, H. M., Kim do, H., Jung, W. H. & Koo, J. S. Metabolic phenotypes in primary unknown metastatic carcinoma. J. Transl. Med. 12, 2 (2014).
    • (2014) J. Transl. Med. , vol.12 , pp. 2
    • Kim, H.M.1    Kim Do, H.2    Jung, W.H.3    Koo, J.S.4
  • 177
    • 0028080101 scopus 로고
    • Glutamateuptake into astrocytes stimulates aerobic glycolysis: A mechanism coupling neuronal activity to glucose utilization
    • Pellerin, L. & Magistretti, P. J. Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization. Proc. Natl Acad. Sci. USA 91, 10625-10629 (1994).
    • (1994) Proc. Natl Acad. Sci. USA , vol.91 , pp. 10625-10629
    • Pellerin, L.1    Magistretti, P.J.2
  • 178
    • 3042793425 scopus 로고    scopus 로고
    • Neuralactivity triggers neuronal oxidative metabolism followed by astrocytic glycolysis
    • Kasischke, K. A., Vishwasrao, H. D., Fisher, P. J., Zipfel, W. R. & Webb, W. W. Neural activity triggers neuronal oxidative metabolism followed by astrocytic glycolysis. Science 305, 99-103 (2004).
    • (2004) Science , vol.305 , pp. 99-103
    • Kasischke, K.A.1    Vishwasrao, H.D.2    Fisher, P.J.3    Zipfel, W.R.4    Webb, W.W.5
  • 179
    • 84866665390 scopus 로고    scopus 로고
    • Mitochondriaand cancer
    • Wallace, D. C. Mitochondria and cancer. Nature Rev. Cancer 12, 685-698 (2012).
    • (2012) Nature Rev. Cancer , vol.12 , pp. 685-698
    • Wallace, D.C.1
  • 180
    • 84897537717 scopus 로고    scopus 로고
    • Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides
    • Birsoy, K. et al. Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides. Nature 508, 108-112 (2014).
    • (2014) Nature , vol.508 , pp. 108-112
    • Birsoy, K.1
  • 181
    • 84894542141 scopus 로고    scopus 로고
    • Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments
    • Zhang, X. et al. Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments. Nature Commun. 5, 3295 (2014).
    • (2014) Nature Commun. , vol.5 , pp. 3295
    • Zhang, X.1
  • 182
    • 82255192310 scopus 로고    scopus 로고
    • Pretreatment mitochondrial priming correlates with clinical response to cytotoxic chemotherapy
    • Ni Chonghaile, T. et al. Pretreatment mitochondrial priming correlates with clinical response to cytotoxic chemotherapy. Science 334, 1129-1133 (2011).
    • (2011) Science , vol.334 , pp. 1129-1133
    • Ni Chonghaile, T.1
  • 183
    • 0035860690 scopus 로고    scopus 로고
    • Palmitoylation of caveolin-1 at a single site (Cys-156) controls its coupling to the c-Src tyrosine kinase: Targeting of dually acylated molecules (GPI-linked, transmembrane, or cytoplasmic) to caveolae effectively uncouples c-Src and caveolin-1 (TYR 14)
    • Lee, H. et al. Palmitoylation of caveolin-1 at a single site (Cys-156) controls its coupling to the c-Src tyrosine kinase: targeting of dually acylated molecules (GPI-linked, transmembrane, or cytoplasmic) to caveolae effectively uncouples c-Src and caveolin-1 (TYR 14). J. Biol. Chem. 276, 35150-35158 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 35150-35158
    • Lee, H.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.