Clinical and functional significance of loss of caveolin-1 expression in breast cancer-associated fibroblasts

Journal of Pathology

Volumn 227, Issue 4, 2012, Pages 490-498

  Simpkins, Samantha A ^a   Hanby, Andrew M ^a   Holliday, Deborah L ^a   Speirs, Valerie ^a  

^a ST JAMES S UNIVERSITY HOSPITAL   (United Kingdom)

Author keywords

breast; caveolin 1; invasion; stroma

Indexed keywords

CAVEOLIN 1; SMALL INTERFERING RNA; UVOMORULIN;

ADULT; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER INVASION; CANCER PROGNOSIS; CELL ASSAY; CELL INVASION; CONTROLLED STUDY; CULTURE MEDIUM; DISEASE FREE SURVIVAL; FIBROBLAST; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOTHESIS; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MULTIVARIATE ANALYSIS; MYOEPITHELIUM CELL; OUTCOME ASSESSMENT; PREDICTION; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN DEPLETION; PROTEIN EXPRESSION; STATISTICAL SIGNIFICANCE; STROMA CELL; TUMOR CELL; WESTERN BLOTTING;

BREAST NEOPLASMS; CADHERINS; CAVEOLIN 1; CELL LINE, TUMOR; CELLS, CULTURED; DISEASE-FREE SURVIVAL; DOWN-REGULATION; FEMALE; FIBROBLASTS; HUMANS; MIDDLE AGED; PROGNOSIS; RNA, SMALL INTERFERING; TUMOR MARKERS, BIOLOGICAL;

EID: 84863724126     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.4034     Document Type: Article

References (30)

1. Kalluri R, Zeisberg M,. Fibroblasts in cancer. Nature Rev Cancer 2006; 6: 392-401.
2. Tlsty TD, Hein PW,. Know thy neighbor: stromal cells can contribute oncogenic signals. Curr Opin Gen Dev 2001; 11: 54-59.
3. Sappino A, Skalli O, Jackson B, et al., Smooth-muscle differentiation in stromal cells of malignant and non-malignant breast tissues. Int J Cancer 1988; 41: 707-712.
4. Lazard D, Sastre X, Frid MG, et al., Expression of smooth muscle-specific proteins in myoepithelium and stromal myofibroblasts of normal and malignant human breast tissue. Proc Natl Acad Sci U S A 1993; 90: 999-1003.
5. Mueller MM, Fusenig NE,. Friends or foesâ€"bipolar effects of the tumour stroma in cancer. Nature Rev Cancer 2004; 4: 839-849.
6. Ronnov-Jensen L, Peterson OW, Bissel MJ,. Cellular changes involved in conversion of normal to malignant breast: importance of the stromal reaction. Physiol Rev 1996; 76: 69-125.
7. Hnasko R, Lisanti M,. The biology of caveolae: lessons from caveolin knockout mice and implications for human disease. Mol Interv 2003; 3: 445-464.
8. Cohen AW, Hnasko R, Schubert W, et al., Role of caveolae and caveolins in health and disease. Physiol Rev 2004; 84: 1341-1379.
9. Witkiewicz A, Dasgupta A, Sotiga F, et al., An absence of stromal caveolin-1 expression predicts early tumour recurrence and poor clinical outcome in human breast cancers. Am J Pathol 2009; 174: 2023-2034.
10. Sloan EK, Ciocca DR, Pouliot N, et al., Stromal cell expression of caveolin-1 predicts outcome in breast cancer. Am J Pathol 2009; 174: 2035-2043.
11. Qian N, Ueno T, Kawaguchi-Sakita N, et al., Prognostic significance of tumour/stromal caveolin-1 expression in breast cancer patients. Cancer Sci 2011; 102: 1590-1596.
12. Koo JS, Park S, Kim SI, et al., The impact of caveolin protein expression in tumour stroma on prognosis in breast cancer. Tumor Biol 2011; 32: 787-799.
13. El-Gendi SM, Mostafa MF, El-Gendi AM,. Stromal caveolin-1 expression in breast carcinoma. Correlation with early tumour recurrence and clinical outcome. Pathol Oncol Res 2012; 18: 459-469.
14. Dingemans KP, Zeeman-Boeschoten IM, Keep RF, et al., Transplantation of colon carcinoma into granulation tissue induces an invasive morphotype. Int J Cancer 1993; 54: 1010-1016.
15. Wu KN, Queenan M, Brody JR, et al., Loss of stromal caveolin-1 expression in malignant melanoma metastases predicts poor survival. Cell Cycle 2011; 10: 4250-4255.
16. Sotiga F, Del Galdo R, Casimiro MC, et al., Caveolin-1-/- null mammary stromal fibroblasts share characteristics with human breast cancer-associated fibroblasts. Am J Pathol 2009; 174: 746-761.
17. Pavlides S, Whitaker-Menezes D, Castello-Cros R, et al., The reverse Warburg effect: aerobic glycolysis in cancer associated fibroblasts and the tumour stroma. Cell Cycle 2009; 8: 3984-4001.
18. Bouras T, Lisanti M, Pestell RG,. Caveolin-1 in breast cancer. Cancer Biol Ther 2004; 3: 931-941.
19. O'Hare MJ, Bond J, Clarke C, et al., Conditional immortalization of freshly isolated human mammary fibroblasts and endothelial cells. Proc Natl Acad Sci U S A 2001; 98: 646-651.
20. Gordon LA, Mulligan KT, Maxwell-Jones H, et al., Breast cell invasive potential relates to the myoepithelial phenotype. Int J Cancer 2003; 106: 8-16.
21. Holliday DL, Hughes S, Shaw JA, et al., Intrinsic genetic characteristics determine tumour-modifying capacity of fibroblasts: matrix metalloproteinase-3 5A/5A genotype enhances breast cancer cell invasion. Breast Cancer Res 2007; 9:: R67.
22. Holliday DL, Brouilette KT, Markert A, et al., Novel multicellular organotypic models of normal and malignant breast: tools for dissecting the role of the microenvironment in breast cancer progression. Breast Cancer Res 2009; 11: R3.
23. Paulsson J, Sjoblom T, Micke P, et al., Prognostic significance of stromal platelet-derived growth factor beta-receptor expression in human breast cancer. Am J Pathol 2009; 175: 334-341.
24. Makretsov NA, Hayes M, Carter BA, et al., Stromal CD10 expression in invasive breast carcinoma correlates with poor prognosis, estrogen receptor negativity, and high grade. Mod Pathol 2007; 20: 84-89.
25. Powell DW, Mifflin RC, Valentich JD, et al., Myofibroblasts. I. Paracrine cells important in health and disease. Am J Physiol 1999; 277: 1-9.
26. Bouras T, Lisanti MP, Pestell RG,. Caveolin-1 in breast cancer. Cancer Biol Ther 2004; 3: 931-941.
27. Witkiewicz AK, Kline J, Queenan M, et al., Molecular profiling of a lethal tumour microenvironment, as defined by stromal caveolin-1 status in breast cancers. Cell Cycle 2011; 10: 1794-809.
28. Mercier I, Casimiro MC, Wang C, et al., Human breast cancer-associated fibroblasts (CAFs) show caveolin-1 downregulation and RB tumour suppressor functional inactivation: implications for the response to hormonal therapy. Cancer Biol Ther 2008; 7: 1212-1225.
29. Witkiewicz AK, Dasgupta A, Sammons S, et al., Loss of stromal caveolin-1 expression predicts poor clinical outcome in triple negative and basal-like breast cancers. Cancer Biol Ther 2010; 10: 135-143.
30. Witkiewicz AK, Dasgupta A, Nguyen KH, et al., Stromal caveolin-1 levels predict early DCIS progression to invasive breast cancer. Cancer Biol Ther 2009; 8: 1071-1079.