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Volumn 7, Issue , 2012, Pages 423-467

Caveolin-1 and cancer metabolism in the tumor microenvironment: Markers, models, and mechanisms

Author keywords

Aerobic glycolysis; Autophagy; Biomarkers; Cancer cell metabolism; Cancer associated fibroblasts; Tumor microenvironment

Indexed keywords

CARBONATE DEHYDRATASE IX; CAVEOLIN 1; CAVEOLIN 2; CAVEOLIN 3; CYCLIN D1; ENDOTHELIAL NITRIC OXIDE SYNTHASE; FUMARATE HYDRATASE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; ISOCITRATE DEHYDROGENASE; METFORMIN; PLATELET DERIVED GROWTH FACTOR; QUERCETIN; RAS PROTEIN; SMALL INTERFERING RNA; SUCCINATE DEHYDROGENASE; SUPEROXIDE DISMUTASE; TRANSFORMING GROWTH FACTOR BETA; VASCULOTROPIN;

EID: 84855434874     PISSN: 15534006     EISSN: 15534014     Source Type: Book Series    
DOI: 10.1146/annurev-pathol-011811-120856     Document Type: Review
Times cited : (252)

References (300)
  • 2
    • 0031047967 scopus 로고    scopus 로고
    • Mutational analysis of the properties of caveolin-1. A novel role for the C-terminal domain in mediating homo-typic caveolin-caveolin interactions
    • DOI 10.1074/jbc.272.7.4398
    • Song KS, Tang Z, Li S, Lisanti MP. 1997. Mutational analysis of the properties of caveolin-1. A novel role for the C-terminal domain in mediating homotypic caveolin-caveolin interactions. J. Biol. Chem. 272:4398-403 (Pubitemid 27078516)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.7 , pp. 4398-4403
    • Song, K.S.1    Tang, Z.2    Li, S.3    Lisanti, M.P.4
  • 3
    • 42949174820 scopus 로고    scopus 로고
    • A critical role of cavin (polymerase i and transcript release factor) in caveolae formation and organization
    • Liu L, Pilch PF. 2008. A critical role of cavin (polymerase I and transcript release factor) in caveolae formation and organization. J. Biol. Chem. 283:4314-22
    • (2008) J. Biol. Chem , vol.283 , pp. 4314-22
    • Liu, L.1    Pilch, P.F.2
  • 4
    • 53049091996 scopus 로고    scopus 로고
    • Deletion of cavin/PTRF causes global loss of caveolae, dyslipidemia, and glucose intolerance
    • Liu L, Brown D, McKeeM, Lebrasseur NK, Yang D, et al. 2008. Deletion of cavin/PTRF causes global loss of caveolae, dyslipidemia, and glucose intolerance. Cell Metab. 8:310-17
    • (2008) Cell Metab , vol.8 , pp. 310-17
    • Liu, L.1    Brown, D.2    McKee, M.3    Lebrasseur, N.K.4    Yang, D.5
  • 5
    • 0031692336 scopus 로고    scopus 로고
    • The caveolae membrane system
    • DOI 10.1146/annurev.biochem.67.1.199
    • Anderson RG. 1998. The caveolae membrane system. Annu. Rev. Biochem. 67:199-225 (Pubitemid 28411129)
    • (1998) Annual Review of Biochemistry , vol.67 , pp. 199-225
    • Anderson, R.G.W.1
  • 6
    • 0033520374 scopus 로고    scopus 로고
    • Expression of caveolin-1 is required for the transport of caveolin-2 to the plasma membrane. Retention of caveolin-2 at the level of the Golgi complex
    • Parolini I, Sargiacomo M, Galbiati F, Rizzo G, Grignani F, et al. 1999. Expression of caveolin-1 is required for the transport of caveolin-2 to the plasma membrane. Retention of caveolin-2 at the level of the Golgi complex. J. Biol. Chem. 274:25718-25
    • (1999) J. Biol. Chem , vol.274 , pp. 25718-25
    • Parolini, I.1    Sargiacomo, M.2    Galbiati, F.3    Rizzo, G.4    Grignani, F.5
  • 8
    • 0035851197 scopus 로고    scopus 로고
    • Caveolin-1 null mice are viable but show evidence of hyperproliferative and vascular abnormalities
    • Razani B, Engelman JA, Wang XB, Schubert W, Zhang XL, et al. 2001. Caveolin-1 null mice are viable but show evidence of hyperproliferative and vascular abnormalities. J. Biol. Chem. 276:38121-38
    • (2001) J. Biol. Chem , vol.276 , pp. 38121-38
    • Razani, B.1    Engelman, J.A.2    Wang, X.B.3    Schubert, W.4    Zhang, X.L.5
  • 9
    • 0035877753 scopus 로고    scopus 로고
    • Caveolin-3 null mice show a loss of caveolae, changes in the microdomain distribution of the dystrophin-glycoprotein complex, and T-tubule abnormalities
    • Galbiati F, Engelman JA, Volonte D, Zhang XL, Minetti C, et al. 2001. Caveolin-3 null mice show a loss of caveolae, changes in the microdomain distribution of the dystrophin-glycoprotein complex, and T-tubule abnormalities. J. Biol. Chem. 276:21425-33
    • (2001) J. Biol. Chem , vol.276 , pp. 21425-33
    • Galbiati, F.1    Engelman, J.A.2    Volonte, D.3    Zhang, X.L.4    Minetti, C.5
  • 10
    • 0026454933 scopus 로고
    • Sequence and expression of caveolin, a protein component of caveolae plasma membrane domains phosphorylated on tyrosine in Rous sarcoma virus-transformed fibroblasts
    • Glenney JR Jr, Soppet D. 1992. Sequence and expression of caveolin, a protein component of caveolae plasma membrane domains phosphorylated on tyrosine in Rous sarcoma virus-transformed fibroblasts. Proc. Natl. Acad. Sci. USA 89:10517-21
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 10517-21
    • Glenney Jr., J.R.1    Soppet, D.2
  • 11
    • 1542297710 scopus 로고    scopus 로고
    • Mechanism of Platelet-Derived Growth Factor-Dependent Caveolin-1 Phosphorylation: Relationship to Sterol Binding and the Role of Serine-80
    • DOI 10.1021/bi035442c
    • Fielding PE, Chau P, Liu D, Spencer TA, Fielding CJ. 2004. Mechanism of platelet-derived growth factor-dependent caveolin-1 phosphorylation: relationship to sterol binding and the role of serine-80. Biochemistry 43:2578-86 (Pubitemid 38327853)
    • (2004) Biochemistry , vol.43 , Issue.9 , pp. 2578-2586
    • Fielding, P.E.1    Chau, P.2    Liu, D.3    Spencer, T.A.4    Fielding, C.J.5
  • 12
    • 0033659710 scopus 로고    scopus 로고
    • Constitutive and growth factor- regulated phosphorylation of caveolin-1 occurs at the same site (Tyr-14) in vivo: Identification of a c-Src/Cav-1/Grb7 signaling cassette
    • Lee H, Volonte D, Galbiati F, Iyengar P, Lublin DM, et al. 2000. Constitutive and growth factor- regulated phosphorylation of caveolin-1 occurs at the same site (Tyr-14) in vivo: identification of a c-Src/Cav-1/Grb7 signaling cassette. Mol. Endocrinol. 14:1750-75
    • (2000) Mol. Endocrinol , vol.14 , pp. 1750-75
    • Lee, H.1    Volonte, D.2    Galbiati, F.3    Iyengar, P.4    Lublin, D.M.5
  • 13
    • 0037341849 scopus 로고    scopus 로고
    • C-Abl is required for oxidative stress-induced phosphorylation of caveolin-1 on tyrosine 14
    • DOI 10.1016/S0898-6568(02)00090-6, PII S0898656802000906
    • Sanguinetti AR, Mastick CC. 2003. c-Abl is required for oxidative stress-induced phosphorylation of caveolin-1 on tyrosine 14. Cell Signal 15:289-98 (Pubitemid 36071673)
    • (2003) Cellular Signalling , vol.15 , Issue.3 , pp. 289-298
    • Sanguinetti, A.R.1    Mastick, C.C.2
  • 14
    • 0035896560 scopus 로고    scopus 로고
    • Cellular stress induces the tyrosine phosphorylation of caveolin-1 (Tyr(14)) via activation of p38 mitogen-activated protein kinase and c-Src kinase. Evidence for caveolae, the actin cytoskeleton, and focal adhesions as mechanical sensors of osmotic stress
    • Volonte D, Galbiati F, Pestell RG, Lisanti MP. 2001. Cellular stress induces the tyrosine phosphorylation of caveolin-1 (Tyr(14)) via activation of p38 mitogen-activated protein kinase and c-Src kinase. Evidence for caveolae, the actin cytoskeleton, and focal adhesions as mechanical sensors of osmotic stress. J. Biol. Chem. 276:8094-103
    • (2001) J. Biol. Chem , vol.276 , pp. 8094-103
    • Volonte, D.1    Galbiati, F.2    Pestell, R.G.3    Lisanti, M.P.4
  • 15
    • 0033529643 scopus 로고    scopus 로고
    • A role for the caveolin scaffolding domain in mediating the membrane attachment of caveolin-1. The caveolin scaffolding domain is both necessary and sufficient for membrane binding in vitro
    • Schlegel A, Schwab RB, Scherer PE, Lisanti MP. 1999. A role for the caveolin scaffolding domain in mediating the membrane attachment of caveolin-1. The caveolin scaffolding domain is both necessary and sufficient for membrane binding in vitro. J. Biol. Chem. 274:22660-67
    • (1999) J. Biol. Chem , vol.274 , pp. 22660-67
    • Schlegel, A.1    Schwab, R.B.2    Scherer, P.E.3    Lisanti, M.P.4
  • 16
    • 0037133502 scopus 로고    scopus 로고
    • Mutational analysis identifies a short atypical membrane attachment sequence (KYWFYR) within caveolin-1
    • DOI 10.1021/bi0120751
    • Woodman SE, Schlegel A, Cohen AW, Lisanti MP. 2002. Mutational analysis identifies a short atypical membrane attachment sequence (KYWFYR) within caveolin-1. Biochemistry 41:3790-95 (Pubitemid 34224693)
    • (2002) Biochemistry , vol.41 , Issue.11 , pp. 3790-3795
    • Woodman, S.E.1    Schlegel, A.2    Cohen, A.W.3    Lisanti, M.P.4
  • 18
    • 0027275642 scopus 로고
    • Signal transducing molecules and glycosyl-phosphatidylinositol-linked proteins form a caveolin-rich insoluble complex in MDCK cells
    • Sargiacomo M, Sudol M, Tang Z, Lisanti MP. 1993. Signal transducing molecules and glycosylphosphatidylinositol- linked proteins form a caveolin-rich insoluble complex in MDCK cells. J. Cell Biol. 122:789-807 (Pubitemid 23241090)
    • (1993) Journal of Cell Biology , vol.122 , Issue.4 , pp. 789-807
    • Sargiacomo, M.1    Sudol, M.2    Tang, Z.3    Lisanti, M.P.4
  • 20
    • 0028285191 scopus 로고
    • Caveolae, caveolin and caveolin-rich membrane domains: A signalling hypothesis
    • DOI 10.1016/0962-8924(94)90114-7
    • LisantiMP, Scherer PE, Tang Z, Sargiacomo M. 1994. Caveolae, caveolin and caveolin-rich membrane domains: a signaling hypothesis. Trends Cell Biol. 4:231-35 (Pubitemid 24190653)
    • (1994) Trends in Cell Biology , vol.4 , Issue.7 , pp. 231-235
    • Lisanti, M.P.1    Scherer, P.E.2    Tang, Z.3    Sargiacomo, M.4
  • 21
    • 0030941001 scopus 로고    scopus 로고
    • Identification of peptide and protein ligands for the caveolin- scaffolding domain. Implications for the interaction of caveolin with caveolae-associated proteins
    • DOI 10.1074/jbc.272.10.6525
    • Couet J, Li S, Okamoto T, Ikezu T, Lisanti MP. 1997. Identification of peptide and protein ligands for the caveolin-scaffolding domain. Implications for the interaction of caveolin with caveolae-associated proteins. J. Biol. Chem. 272:6525-33 (Pubitemid 27118133)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.10 , pp. 6525-6533
    • Couet, J.1    Li, S.2    Okamoto, T.3    Ikezu, T.4    Lisanti, M.P.5
  • 22
    • 0032489443 scopus 로고    scopus 로고
    • Caveolins, a family of scaffolding proteins for organizing 'preassembled signaling complexes' at the plasma membrane
    • DOI 10.1074/jbc.273.10.5419
    • Okamoto T, Schlegel A, Scherer PE, Lisanti MP. 1998. Caveolins, a family of scaffolding proteins for organizing "preassembled signaling complexes" at the plasma membrane. J. Biol. Chem. 273:5419-22 (Pubitemid 28123999)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.10 , pp. 5419-5422
    • Okamoto, T.1    Schlegel, A.2    Scherer, P.E.3    Lisanti, M.P.4
  • 23
    • 0029787241 scopus 로고    scopus 로고
    • Endothelial nitric oxide synthase targeting to caveolae. Specific interactions with caveolin isoforms in cardiac myocytes and endothelial cells
    • DOI 10.1074/jbc.271.37.22810
    • Feron O, Belhassen L, Kobzik L, Smith TW, Kelly RA, Michel T. 1996. Endothelial nitric oxide synthase targeting to caveolae. Specific interactions with caveolin isoforms in cardiac myocytes and endothelial cells. J. Biol. Chem. 271:22810-14 (Pubitemid 26304729)
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.37 , pp. 22810-22814
    • Feron, O.1    Belhassen, L.2    Kobzik, L.3    Smith, T.W.4    Kelly, R.A.5    Michel, T.6
  • 24
    • 0029803093 scopus 로고    scopus 로고
    • Src tyrosine kinases, G(α) subunits, and H-Ras share a common membrane- anchored scaffolding protein, caveolin: Caveolin binding negatively regulates the auto-activation of Src tyrosine kinases
    • DOI 10.1074/jbc.271.46.29182
    • Li S, Couet J, Lisanti MP. 1996. Src tyrosine kinases, Gα subunits, and H-Ras share a common membrane-anchored scaffolding protein, caveolin. Caveolin binding negatively regulates the autoactivation of Src tyrosine kinases. J. Biol. Chem. 271:29182-90 (Pubitemid 26382628)
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.46 , pp. 29182-29190
    • Li, S.1    Couet, J.2    Lisanti, M.P.3
  • 26
    • 0030731231 scopus 로고    scopus 로고
    • Interaction of a receptor tyrosine kinase, EGF-R, with caveolins. Caveolin binding negatively regulates tyrosine and serine/threonine kinase activities
    • DOI 10.1074/jbc.272.48.30429
    • Couet J, Sargiacomo M, Lisanti MP. 1997. Interaction of a receptor tyrosine kinase, EGF-R, with caveolins. Caveolin binding negatively regulates tyrosine and serine/threonine kinase activities. J. Biol. Chem. 272:30429-38 (Pubitemid 27512253)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.48 , pp. 30429-30438
    • Couet, J.1    Sargiacomo, M.2    Lisanti, M.P.3
  • 27
    • 0036733284 scopus 로고    scopus 로고
    • Caveolae: From cell biology to animal physiology
    • Razani B, Woodman SE, Lisanti MP. 2002. Caveolae: from cell biology to animal physiology. Pharmacol. Rev. 54:431-67
    • (2002) Pharmacol. Rev , vol.54 , pp. 431-67
    • Razani, B.1    Woodman, S.E.2    Lisanti, M.P.3
  • 28
    • 1342267006 scopus 로고    scopus 로고
    • Caveolinlopathies: Mutations in caveolin-3 cause four distinct autosomal dominant muscle diseases
    • Woodman SE, Sotgia F, Galbiati F, Minetti C, Lisanti MP. 2004. Caveolinopathies: Mutations in caveolin-3 cause four distinct autosomal dominant muscle diseases. Neurology 62:538-43 (Pubitemid 38252792)
    • (2004) Neurology , vol.62 , Issue.4 , pp. 538-543
    • Woodman, S.E.1    Sotgia, F.2    Galbiati, F.3    Minetti, C.4    Lisanti, M.P.5
  • 33
    • 0030953208 scopus 로고    scopus 로고
    • 2+- calmodulin and caveolin
    • DOI 10.1074/jbc.272.25.15583
    • Michel JB, Feron O, Sacks D, Michel T. 1997. Reciprocal regulation of endothelial nitric-oxide synthase by Ca2+-calmodulin and caveolin. J. Biol. Chem. 272:15583-86 (Pubitemid 27265522)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.25 , pp. 15583-15586
    • Michel, J.B.1    Feron, O.2    Sacks, D.3    Michel, T.4
  • 34
    • 0039397709 scopus 로고    scopus 로고
    • Dissecting the interaction between nitric oxide synthase (NOS) and caveolin. Functional significance of the nos caveolin binding domain in vivo
    • DOI 10.1074/jbc.272.41.25437
    • Garcia-Cardena G, Martasek P, Masters BS, Skidd PM, Couet J, et al. 1997. Dissecting the interaction between nitric oxide synthase (NOS) and caveolin. Functional significance of the NOS caveolin binding domain in vivo. J. Biol. Chem. 272:25437-40 (Pubitemid 27438846)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.41 , pp. 25437-25440
    • Garcia-Cardena, G.1    Martasek, P.2    Masters, B.S.S.3    Skidd, P.M.4    Couet, J.5    Li, S.6    Lisanti, M.P.7    Sessa, W.C.8
  • 37
    • 0029847608 scopus 로고    scopus 로고
    • Palmitoylation of endothelial nitric oxide synthase is necessary for optimal stimulated release of nitric oxide: Implications for caveolae localization
    • DOI 10.1021/bi961720e
    • Liu J, Garcia-Cardena G, Sessa WC. 1996. Palmitoylation of endothelial nitric oxide synthase is necessary for optimal stimulated release of nitric oxide: implications for caveolae localization. Biochemistry 35:13277-81 (Pubitemid 26349419)
    • (1996) Biochemistry , vol.35 , Issue.41 , pp. 13277-13281
    • Liu, J.1    Garcia-Cardena, G.2    Sessa, W.C.3
  • 38
    • 0029910141 scopus 로고    scopus 로고
    • Endothelial nitric oxide synthase is regulated by tyrosine phosphorylation and interacts with caveolin-1
    • DOI 10.1074/jbc.271.44.27237
    • Garcia-Cardena G, Fan R, Stern DF, Liu J, Sessa WC. 1996. Endothelial nitric oxide synthase is regulated by tyrosine phosphorylation and interacts with caveolin-1. J. Biol. Chem. 271:27237-40 (Pubitemid 26367273)
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.44 , pp. 27237-27240
    • Garcia-Cardena, G.1    Fan, R.2    Stern, D.F.3    Liu, J.4    Sessa, W.C.5
  • 39
    • 68849084669 scopus 로고    scopus 로고
    • Persistent eNOS activation secondary to caveolin-1 deficiency induces pulmonary hypertension in mice and humans through PKG nitration
    • Zhao YY, Zhao YD, Mirza MK, Huang JH, Potula HH, et al. 2009. Persistent eNOS activation secondary to caveolin-1 deficiency induces pulmonary hypertension in mice and humans through PKG nitration. J. Clin. Investig. 119:2009-18
    • (2009) J. Clin. Investig , vol.119 , pp. 2009-18
    • Zhao, Y.Y.1    Zhao, Y.D.2    Mirza, M.K.3    Huang, J.H.4    Potula, H.H.5
  • 40
    • 0034529950 scopus 로고    scopus 로고
    • In vivo delivery of the caveolin-1 scaffolding domain inhibits nitric oxide synthesis and reduces inflammation
    • DOI 10.1038/82176
    • Bucci M, Gratton JP, Rudic RD, Acevedo L, Roviezzo F, et al. 2000. In vivo delivery of the caveolin-1 scaffolding domain inhibits nitric oxide synthesis and reduces inflammation. Nat. Med. 6:1362-67 (Pubitemid 32001020)
    • (2000) Nature Medicine , vol.6 , Issue.12 , pp. 1362-1367
    • Bucci, M.1    Gratton, J.-P.2    Rudic, R.D.3    Acevedo, L.4    Roviezzo, F.5    Cirino, G.6    Sessa, W.C.7
  • 42
    • 2642549186 scopus 로고    scopus 로고
    • Combined loss of INK4a and caveolin-1 synergistically enhances cell proliferation and oncogene-induced tumorigenesis. Role of INK4a/CAV-1 in mammary epithelial cell hyperplasia
    • DOI 10.1074/jbc.M402064200
    • Williams TM, Lee H, Cheung MW, Cohen AW, Razani B, et al. 2004. Combined loss of INK4a and caveolin-1 synergistically enhances cell proliferation and oncogene-induced tumorigenesis: role of INK4a/CAV-1 in mammary epithelial cell hyperplasia. J. Biol. Chem. 279:24745-56 (Pubitemid 38725342)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.23 , pp. 24745-24756
    • Williams, T.M.1    Lee, H.2    Cheung, M.W.-C.3    Cohen, A.W.4    Razani, B.5    Iyengar, P.6    Scherer, P.E.7    Pestell, R.G.8    Lisanti, M.P.9
  • 46
    • 0029879507 scopus 로고    scopus 로고
    • Localization of platelet-derived growth factor-stimulated phosphorylation cascade to caveolae
    • DOI 10.1074/jbc.271.17.10299
    • Liu P, Ying Y, Ko YG, Anderson RG. 1996. Localization of platelet-derived growth factor-stimulated phosphorylation cascade to caveolae. J. Biol. Chem. 271:10299-303 (Pubitemid 26132521)
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.17 , pp. 10299-10303
    • Liu, P.1    Ying, Y.2    Ko, Y.-G.3    Anderson, R.G.W.4
  • 47
    • 15844431258 scopus 로고    scopus 로고
    • Localization of epidermal growth factor-stimulated Ras/Raf-1 interaction to caveolae membrane
    • DOI 10.1074/jbc.271.20.11930
    • Mineo C, James GL, Smart EJ, Anderson RG. 1996. Localization of epidermal growth factor-stimulated Ras/Raf-1 interaction to caveolae membrane. J. Biol. Chem. 271:11930-35 (Pubitemid 26157268)
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.20 , pp. 11930-11935
    • Mineo, C.1    James, G.L.2    Smart, E.J.3    Anderson, R.G.W.4
  • 48
    • 0029912981 scopus 로고    scopus 로고
    • Co-purification and direct interaction of Ras with caveolin, an integral membrane protein of caveolae microdomains. Detergent-free purification of caveolae microdomains
    • Song KS, Li S, Okamoto T, Quilliam LA, Sargiacomo M, Lisanti MP. 1996. Co-purification and direct interaction of Ras with caveolin, an integral membrane protein of caveolae microdomains. Detergent-free purification of caveolae microdomains. J. Biol. Chem. 271:9690-97
    • (1996) J. Biol. Chem , vol.271 , pp. 9690-97
    • Song, K.S.1    Li, S.2    Okamoto, T.3    Quilliam, L.A.4    Sargiacomo, M.5    Lisanti, M.P.6
  • 50
    • 0032577647 scopus 로고    scopus 로고
    • Caveolin-mediated regulation of signaling along the p42/44 MAP kinase cascade in vivo: A role for the caveolin-scaffolding domain
    • DOI 10.1016/S0014-5793(98)00470-0, PII S0014579398004700
    • Engelman JA, Chu C, Lin A, Jo H, Ikezu T, et al. 1998. Caveolin-mediated regulation of signaling along the p42/44 MAP kinase cascade in vivo. A role for the caveolin-scaffolding domain. FEBS Lett. 428:205-11 (Pubitemid 28319685)
    • (1998) FEBS Letters , vol.428 , Issue.3 , pp. 205-211
    • Engelman, J.A.1    Chu, C.2    Lin, A.3    Jo, H.4    Ikezu, T.5    Okamoto, T.6    Kohtz, D.S.7    Lisanti, M.P.8
  • 52
    • 0034617296 scopus 로고    scopus 로고
    • Caveolin-1 inhibits epidermal growth factor-stimulated lamellipod extension and cell migration in metastatic mammary adenocarcinoma cells (MTLn3): Transformation suppressor effects of adenovirus-mediated gene delivery of caveolin-1
    • DOI 10.1074/jbc.M909895199
    • Zhang W, Razani B, Altschuler Y, Bouzahzah B, Mostov KE, et al. 2000. Caveolin-1 inhibits epidermal growth factor-stimulated lamellipod extension and cell migration in metastatic mammary adenocarcinoma cells (MTLn3). Transformation suppressor effects of adenovirus-mediated gene delivery of caveolin-1. J. Biol. Chem. 275:20717-25 (Pubitemid 30457660)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.27 , pp. 20717-20725
    • Zhang, W.1    Razani, B.2    Altschuler, Y.3    Bouzahzah, B.4    Mostov, K.E.5    Pestell, R.G.6    Lisanti, M.P.7
  • 53
    • 0032538790 scopus 로고    scopus 로고
    • Targeted downregulation of caveolin-1 is sufficient to drive cell transformation and hyperactivate the p42/44 MAP kinase cascade
    • Galbiati F, Volonte D, Engelman JA, Watanabe G, Burk R, et al. 1998. Targeted downregulation of caveolin-1 is sufficient to drive cell transformation and hyperactivate the p42/44 MAP kinase cascade. EMBO J. 17:6633-48 (Pubitemid 28521797)
    • (1998) EMBO Journal , vol.17 , Issue.22 , pp. 6633-6648
    • Galbiati, F.1    Volonte, D.2    Engelman, J.A.3    Watanabe, G.4    Burk, R.5    Pestell, R.G.6    Lisanti, M.P.7
  • 55
    • 0030960332 scopus 로고    scopus 로고
    • Recombinant expression of caveolin-1 in oncogenically transformed cells abrogates anchorage-independent growth
    • DOI 10.1074/jbc.272.26.16374
    • Engelman JA, Wykoff CC, Yasuhara S, Song KS, Okamoto T, Lisanti MP. 1997. Recombinant expression of caveolin-1 in oncogenically transformed cells abrogates anchorage-independent growth. J. Biol. Chem. 272:16374-81 (Pubitemid 27276462)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.26 , pp. 16374-16381
    • Engelman, J.A.1    Wykoff, C.C.2    Yasuhara, S.3    Song, K.S.4    Okamoto, T.5    Lisanti, M.P.6
  • 56
    • 70249093948 scopus 로고    scopus 로고
    • The absence of caveolin- 1 increases proliferation and anchorage-independent growth by a Rac-dependent, Erk-independent mechanism
    • Cerezo A, Guadamillas MC, Goetz JG, Sanchez-Perales S, Klein E, et al. 2009. The absence of caveolin- 1 increases proliferation and anchorage-independent growth by a Rac-dependent, Erk-independent mechanism. Mol. Cell. Biol. 29:5046-59
    • (2009) Mol. Cell. Biol , vol.29 , pp. 5046-59
    • Cerezo, A.1    Guadamillas, M.C.2    Goetz, J.G.3    Sanchez-Perales, S.4    Klein, E.5
  • 58
    • 24644466511 scopus 로고    scopus 로고
    • Stroma-derived three-dimensional matrices are necessary and sufficient to promote desmoplastic differentiation of normal fibroblasts
    • Amatangelo MD, Bassi DE, Klein-Szanto AJ, Cukierman E. 2005. Stroma-derived three-dimensional matrices are necessary and sufficient to promote desmoplastic differentiation of normal fibroblasts. Am. J. Pathol. 167:475-88 (Pubitemid 43026103)
    • (2005) American Journal of Pathology , vol.167 , Issue.2 , pp. 475-488
    • Amatangelo, M.D.1    Bassi, D.E.2    Klein-Szanto, A.J.P.3    Cukierman, E.4
  • 59
    • 0141751743 scopus 로고    scopus 로고
    • The presence of a fibrotic focus in invasive breast carcinoma correlates with the expression of carbonic anhydrase IX and is a marker of hypoxia and poor prognosis
    • DOI 10.1023/A:1025702330207
    • Colpaert CG, Vermeulen PB, Fox SB, Harris AL, Dirix LY, Van Marck EA. 2003. The presence of a fibrotic focus in invasive breast carcinoma correlates with the expression of carbonic anhydrase IX and is a marker of hypoxia and poor prognosis. Breast Cancer Res. Treat. 81:137-47 (Pubitemid 37211131)
    • (2003) Breast Cancer Research and Treatment , vol.81 , Issue.2 , pp. 137-147
    • Colpaert, C.G.1    Vermeulen, P.B.2    Fox, S.B.3    Harris, A.L.4    Dirix, L.Y.5    Van Marck, E.A.6
  • 61
    • 70450222098 scopus 로고    scopus 로고
    • Matrix crosslinking forces tumor progression by enhancing integrin signaling
    • Levental KR, Yu H, Kass L, Lakins JN, Egeblad M, et al. 2009. Matrix crosslinking forces tumor progression by enhancing integrin signaling. Cell 139:891-906
    • (2009) Cell , vol.139 , pp. 891-906
    • Levental, K.R.1    Yu, H.2    Kass, L.3    Lakins, J.N.4    Egeblad, M.5
  • 62
    • 0036892112 scopus 로고    scopus 로고
    • Immunohistochemical expression of extracellular matrix components tenascin, fibronectin, collagen type IV and laminin in breast cancer: Their prognostic value and role in tumour invasion and progression
    • DOI 10.1016/S0959-8049(02)00210-1, PII S0959804902002101
    • Ioachim E, Charchanti A, Briasoulis E, Karavasilis V, Tsanou H, et al. 2002. Immunohistochemical expression of extracellular matrix components tenascin, fibronectin, collagen type IV and laminin in breast cancer: their prognostic value and role in tumor invasion and progression. Eur. J. Cancer 38:2362-70 (Pubitemid 35387487)
    • (2002) European Journal of Cancer , vol.38 , Issue.18 , pp. 2362-2370
    • Ioachim, E.1    Charchanti, A.2    Briasoulis, E.3    Karavasilis, V.4    Tsanou, H.5    Arvanitis, D.L.6    Agnantis, N.J.7    Pavlidis, N.8
  • 63
    • 0027161705 scopus 로고
    • Induction of α-smooth muscle actin by transforming growth factor-β1 in quiescent human breast gland fibroblasts
    • Ronnov-Jessen L, Petersen OW. 1993. Induction of α-smooth muscle actin by transforming growth factor β1 in quiescent human breast gland fibroblasts. Implications for myofibroblast generation in breast neoplasia. Lab. Investig. 68:696-707 (Pubitemid 23202798)
    • (1993) Laboratory Investigation , vol.68 , Issue.6 , pp. 696-707
    • Ronnov-Jessen, L.1    Petersen, O.W.2
  • 65
    • 49249120549 scopus 로고    scopus 로고
    • Carcinoma-associated fibroblast- like differentiation of human mesenchymal stem cells
    • Mishra PJ, Humeniuk R, Medina DJ, Alexe G, Mesirov JP, et al. 2008. Carcinoma-associated fibroblast- like differentiation of human mesenchymal stem cells. Cancer Res. 68:4331-39
    • (2008) Cancer Res , vol.68 , pp. 4331-39
    • Mishra, P.J.1    Humeniuk, R.2    Medina, D.J.3    Alexe, G.4    Mesirov, J.P.5
  • 68
    • 35948945337 scopus 로고    scopus 로고
    • Discovery of endothelial to mesenchymal transition as a source for carcinoma-associated fibroblasts
    • DOI 10.1158/0008-5472.CAN-07-3127
    • Zeisberg EM, Potenta S, Xie L, Zeisberg M, Kalluri R. 2007. Discovery of endothelial to mesenchymal transition as a source for carcinoma-associated fibroblasts. Cancer Res. 67:10123-28 (Pubitemid 350070783)
    • (2007) Cancer Research , vol.67 , Issue.21 , pp. 10123-10128
    • Zeisberg, E.M.1    Potenta, S.2    Xie, L.3    Zeisberg, M.4    Kalluri, R.5
  • 69
    • 18844428327 scopus 로고    scopus 로고
    • Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion
    • DOI 10.1016/j.cell.2005.02.034, PII S0092867405002370
    • Orimo A, Gupta PB, Sgroi DC, Arenzana-Seisdedos F, Delaunay T, et al. 2005. Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell 121:335-48 (Pubitemid 40692295)
    • (2005) Cell , vol.121 , Issue.3 , pp. 335-348
    • Orimo, A.1    Gupta, P.B.2    Sgroi, D.C.3    Arenzana-Seisdedos, F.4    Delaunay, T.5    Naeem, R.6    Carey, V.J.7    Richardson, A.L.8    Weinberg, R.A.9
  • 71
    • 0037276432 scopus 로고    scopus 로고
    • Extracellular matrix-stromal cell contribution to neoplastic phenotype of epithelial cells in the breast
    • DOI 10.1186/bcr580
    • Shekhar MP, Pauley R, Heppner G. 2003. Host microenvironment in breast cancer development: extracellular matrix-stromal cell contribution to neoplastic phenotype of epithelial cells in the breast. Breast Cancer Res. 5:130-35 (Pubitemid 36519405)
    • (2003) Breast Cancer Research , vol.5 , Issue.3 , pp. 130-135
    • Shekhar, M.P.V.1    Pauley, R.2    Heppner, G.3
  • 72
    • 0022891340 scopus 로고
    • Tumors: Wounds that do not heal: Similarities between tumor stroma generation and wound healing
    • Dvorak HF. 1986. Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. N. Engl. J. Med. 315:1650-59 (Pubitemid 17052899)
    • (1986) New England Journal of Medicine , vol.315 , Issue.26 , pp. 1650-1659
    • Dvorak, H.F.1
  • 73
    • 0025354027 scopus 로고
    • Mediation of wound-related Rous sarcoma virus tumorigenesis by TGF-sβ
    • Sieweke MH, Thompson NL, Sporn MB, Bissell MJ. 1990. Mediation of wound-related Rous sarcoma virus tumorigenesis by TGF-sβ. Science 248:1656-60
    • (1990) Science , vol.248 , pp. 1656-60
    • Sieweke, M.H.1    Thompson, N.L.2    Sporn, M.B.3    Bissell, M.J.4
  • 74
    • 0034618408 scopus 로고    scopus 로고
    • Human breast carcinoma desmoplasia is PDGF initiated
    • Shao ZM, Nguyen M, Barsky SH. 2000. Human breast carcinoma desmoplasia is PDGF initiated. Oncogene 19:4337-45
    • (2000) Oncogene , vol.19 , pp. 4337-45
    • Shao, Z.M.1    Nguyen, M.2    Barsky, S.H.3
  • 75
    • 78650563018 scopus 로고    scopus 로고
    • Autocrine TGF-sβand stromal cell-derived factor 1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts
    • Kojima Y, Acar A, Eaton EN, Mellody KT, Scheel C, et al. Autocrine TGF-sβand stromal cell-derived factor 1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts. Proc. Natl. Acad. Sci. USA 107:20009-14
    • Proc. Natl. Acad. Sci. USA , vol.107 , pp. 20009-14
    • Kojima, Y.1    Acar, A.2    Eaton, E.N.3    Mellody, K.T.4    Scheel, C.5
  • 77
    • 58149334773 scopus 로고    scopus 로고
    • A stroma-related gene signature predicts resistance to neoadjuvant chemotherapy in breast cancer
    • Farmer P, Bonnefoi H, Anderle P, Cameron D, Wirapati P, et al. 2009. A stroma-related gene signature predicts resistance to neoadjuvant chemotherapy in breast cancer. Nat. Med. 15:68-74
    • (2009) Nat. Med , vol.15 , pp. 68-74
    • Farmer, P.1    Bonnefoi, H.2    Anderle, P.3    Cameron, D.4    Wirapati, P.5
  • 80
    • 77956281456 scopus 로고    scopus 로고
    • Stromal PDGFR? expression in prostate tumors and nonmalignant prostate tissue predicts prostate cancer survival
    • Hagglof C, Hammarsten P, Josefsson A, Stattin P, Paulsson J, et al. Stromal PDGFR? expression in prostate tumors and nonmalignant prostate tissue predicts prostate cancer survival. PLoS ONE 5:e10747
    • PLoS ONE , vol.5
    • Hagglof, C.1    Hammarsten, P.2    Josefsson, A.3    Stattin, P.4    Paulsson, J.5
  • 81
    • 66549114050 scopus 로고    scopus 로고
    • An absence of stromal caveolin- 1 expression predicts early tumor recurrence and poor clinical outcome in human breast cancers
    • Witkiewicz AK, Dasgupta A, Sotgia F, Mercier I, Pestell RG, et al. 2009. An absence of stromal caveolin- 1 expression predicts early tumor recurrence and poor clinical outcome in human breast cancers. Am. J. Pathol. 174:2023-34
    • (2009) Am. J. Pathol , vol.174 , pp. 2023-34
    • Witkiewicz, A.K.1    Dasgupta, A.2    Sotgia, F.3    Mercier, I.4    Pestell, R.G.5
  • 82
    • 66749106907 scopus 로고    scopus 로고
    • Stromal cell expression of caveolin-1 predicts outcome in breast cancer
    • Sloan EK, Ciocca DR, Pouliot N, Natoli A, Restall C, et al. 2009. Stromal cell expression of caveolin-1 predicts outcome in breast cancer. Am. J. Pathol. 174:2035-43
    • (2009) Am. J. Pathol , vol.174 , pp. 2035-43
    • Sloan, E.K.1    Ciocca, D.R.2    Pouliot, N.3    Natoli, A.4    Restall, C.5
  • 83
    • 77951926346 scopus 로고    scopus 로고
    • Breast tumor stroma is a prognostic indicator and target for therapy
    • Howell A, Landberg G, Bergh J. 2009. Breast tumor stroma is a prognostic indicator and target for therapy. Breast Cancer Res. 11(Suppl. 3):16
    • (2009) Breast Cancer Res , vol.11 , Issue.SUPPL. 3 , pp. 16
    • Howell, A.1    Landberg, G.2    Bergh, J.3
  • 84
    • 49649109716 scopus 로고    scopus 로고
    • Lysyl oxidase-like 2 as a new poor prognosis marker of squamous cell carcinomas
    • Peinado H, Moreno-Bueno G, Hardisson D, Perez-Gomez E, Santos V, et al. 2008. Lysyl oxidase-like 2 as a new poor prognosis marker of squamous cell carcinomas. Cancer Res. 68:4541-50
    • (2008) Cancer Res , vol.68 , pp. 4541-50
    • Peinado, H.1    Moreno-Bueno, G.2    Hardisson, D.3    Perez-Gomez, E.4    Santos, V.5
  • 85
    • 77956425361 scopus 로고    scopus 로고
    • Allosteric inhibition of lysyl oxidase-like 2 impedes the development of a pathologic microenvironment
    • Barry-Hamilton V, Spangler R, Marshall D, McCauley S, Rodriguez HM, et al. 2010. Allosteric inhibition of lysyl oxidase-like 2 impedes the development of a pathologic microenvironment. Nat. Med. 16:1009-17
    • (2010) Nat. Med. , vol.16 , pp. 1009-17
    • Barry-Hamilton, V.1    Spangler, R.2    Marshall, D.3    McCauley, S.4    Rodriguez, H.M.5
  • 86
    • 72849125358 scopus 로고    scopus 로고
    • Targeting fibroblast activation protein inhibits tumor stromagenesis and growth in mice
    • Santos AM, Jung J, Aziz N, Kissil JL, Pure E. 2009. Targeting fibroblast activation protein inhibits tumor stromagenesis and growth in mice. J. Clin. Investig. 119:3613-25
    • (2009) J. Clin. Investig , vol.119 , pp. 3613-25
    • Santos, A.M.1    Jung, J.2    Aziz, N.3    Kissil, J.L.4    Pure, E.5
  • 87
    • 77955443486 scopus 로고    scopus 로고
    • Loss of stromal caveolin-1 expression predicts poor clinical outcome in triple negative and basal-like breast cancers
    • Witkiewicz AK, Dasgupta A, Sammons S, Er O, Potoczek MB, et al. 2010. Loss of stromal caveolin-1 expression predicts poor clinical outcome in triple negative and basal-like breast cancers. Cancer Biol. Ther. 10:125-43
    • (2010) Cancer Biol. Ther. , vol.10 , pp. 125-43
    • Witkiewicz, A.K.1    Dasgupta, A.2    Sammons, S.3    Er, O.4    Potoczek, M.B.5
  • 88
  • 89
    • 68449103256 scopus 로고    scopus 로고
    • An absence of stromal caveolin-1 is associated with advanced prostate cancer, metastatic disease and epithelial Akt activation
    • Di Vizio D, Morello M, Sotgia F, Pestell RG, Freeman MR, Lisanti MP. 2009. An absence of stromal caveolin-1 is associated with advanced prostate cancer, metastatic disease and epithelial Akt activation. Cell Cycle 8:2420-24
    • (2009) Cell Cycle , vol.8 , pp. 2420-24
    • Di Vizio, D.1    Morello, M.2    Sotgia, F.3    Pestell, R.G.4    Freeman, M.R.5    Lisanti, M.P.6
  • 90
    • 0028953271 scopus 로고
    • Reduction of caveolin and caveolae in oncogenically transformed cells
    • Koleske AJ, Baltimore D, Lisanti MP. 1995. Reduction of caveolin and caveolae in oncogenically transformed cells. Proc. Natl. Acad. Sci. USA 92:1381-85
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 1381-85
    • Koleske, A.J.1    Baltimore, D.2    Lisanti, M.P.3
  • 92
    • 0035916914 scopus 로고    scopus 로고
    • Evidence that Myc isoforms transcriptionally repress caveolin-1 gene expression via an INR-dependent mechanism
    • DOI 10.1021/bi002787b
    • Park DS, Razani B, Lasorella A, Schreiber-Agus N, Pestell RG, et al. 2001. Evidence that Myc isoforms transcriptionally repress caveolin-1 gene expression via an INR-dependent mechanism. Biochemistry 40:3354-62 (Pubitemid 32221638)
    • (2001) Biochemistry , vol.40 , Issue.11 , pp. 3354-3362
    • Park, D.S.1    Razani, B.2    Lasorella, A.3    Schreiber-Agus, N.4    Pestell, R.G.5    Iavarone, A.6    Lisanti, M.P.7
  • 93
    • 0034649425 scopus 로고    scopus 로고
    • Caveolin-1 expression is downregulated in cells transformed by the human papilloma virus in a p53-dependent manner. Replacement of caveolin-1 expression suppresses HPV-mediated cell transformation
    • Razani B, Altschuler Y, Zhu L, Pestell RG, Mostov KE, Lisanti MP. 2000. Caveolin-1 expression is downregulated in cells transformed by the human papilloma virus in a p53-dependent manner. Replacement of caveolin-1 expression suppresses HPV-mediated cell transformation. Biochemistry 39:13916-24
    • (2000) Biochemistry , vol.39 , pp. 13916-24
    • Razani, B.1    Altschuler, Y.2    Zhu, L.3    Pestell, R.G.4    Mostov, K.E.5    Lisanti, M.P.6
  • 94
    • 0032546319 scopus 로고    scopus 로고
    • Tumor cell growth inhibition by caveolin re-expression in human breast cancer cells
    • Lee SW, Reimer CL, Oh P, Campbell DB, Schnitzer JE. 1998. Tumor cell growth inhibition by caveolin re-expression in human breast cancer cells. Oncogene 16:1391-97 (Pubitemid 28151846)
    • (1998) Oncogene , vol.16 , Issue.11 , pp. 1391-1397
    • Lee, S.W.1    Reimer, C.L.2    Oh, P.3    Campbell, D.B.4    Schnitzer, J.E.5
  • 95
    • 40949159623 scopus 로고    scopus 로고
    • Mice with cav-1 gene disruption have benign stromal lesions and compromised epithelial differentiation
    • Yang G, Timme TL, Naruishi K, Fujita T, Fattah el MA, et al. 2008. Mice with cav-1 gene disruption have benign stromal lesions and compromised epithelial differentiation. Exp. Mol. Pathol. 84:131-40
    • (2008) Exp. Mol. Pathol , vol.84 , pp. 131-40
    • Yang, G.1    Timme, T.L.2    Naruishi, K.3    Fujita, T.4    Fattahel, M.A.5
  • 96
    • 0036791604 scopus 로고    scopus 로고
    • Caveolin-1 mutations (P132L and null) and the pathogenesis of breast cancer: Caveolin-1 (P132L) behaves in a dominant-negative manner and caveolin-1-/- null mice show mammary epithelial cell hyperplasia
    • LeeH, ParkDS, Razani B, Russell RG, Pestell RG, Lisanti MP. 2002. Caveolin-1 mutations (P132L and null) and the pathogenesis of breast cancer: Caveolin-1 (P132L) behaves in a dominant-negative manner and caveolin-1-/- null mice show mammary epithelial cell hyperplasia. Am. J. Pathol. 161:1357-69
    • (2002) Am. J. Pathol , vol.161 , pp. 1357-69
    • Parkds, L.1    Razani, B.2    Russell, R.G.3    Pestell, R.G.4    Lisanti, M.P.5
  • 98
    • 65349132368 scopus 로고    scopus 로고
    • Genetic ablation of caveolin-1 drives estrogen hypersensitivity and the development of DCIS-like mammary lesions
    • Mercier I, Casimiro MC, Zhou J, Wang C, Plymire C, et al. 2009. Genetic ablation of caveolin-1 drives estrogen hypersensitivity and the development of DCIS-like mammary lesions. Am. J. Pathol. 174:1172-90
    • (2009) Am. J. Pathol , vol.174 , pp. 1172-90
    • Mercier, I.1    Casimiro, M.C.2    Zhou, J.3    Wang, C.4    Plymire, C.5
  • 100
    • 0037303007 scopus 로고    scopus 로고
    • Caveolin-1 null mice develop cardiac hypertrophy with hyperactivation of p42/44 MAP kinase in cardiac fibroblasts
    • Cohen AW, Park DS, Woodman SE, Williams TM, Chandra M, et al. 2003. Caveolin-1 null mice develop cardiac hypertrophy with hyperactivation of p42/44 MAP kinase in cardiac fibroblasts. Am. J. Physiol. Cell Physiol. 284:457-74
    • (2003) Am. J. Physiol. Cell Physiol , vol.284 , pp. 457-74
    • Cohen, A.W.1    Park, D.S.2    Woodman, S.E.3    Williams, T.M.4    Chandra, M.5
  • 101
    • 51849169053 scopus 로고    scopus 로고
    • Decreased expression of caveolin-1 in patients with systemic sclerosis: Crucial role in the pathogenesis of tissue fibrosis
    • Del Galdo F, Sotgia F, de Almeida CJ, Jasmin JF, Musick M, et al. 2008. Decreased expression of caveolin-1 in patients with systemic sclerosis: crucial role in the pathogenesis of tissue fibrosis. Arthritis Rheum. 58:2854-65
    • (2008) Arthritis Rheum , vol.58 , pp. 2854-65
    • Del Galdo, F.1    Sotgia, F.2    De Almeida, C.J.3    Jasmin, J.F.4    Musick, M.5
  • 102
    • 0035794218 scopus 로고    scopus 로고
    • Caveolin-1 regulates transforming growth factor (TGF)-β/SMAD signaling through an interaction with the TGF-sβtype i receptor
    • Razani B, Zhang XL, BitzerM, von Gersdorff G, Bottinger EP, Lisanti MP. 2001. Caveolin-1 regulates transforming growth factor (TGF)-β/SMAD signaling through an interaction with the TGF-sβtype I receptor. J. Biol. Chem. 276:6727-38
    • (2001) J. Biol. Chem , vol.276 , pp. 6727-38
    • Razani, B.1    Zhang, X.L.2    Bitzer, M.3    Von Gersdorff, G.4    Bottinger, E.P.5    Lisanti, M.P.6
  • 105
  • 109
    • 30344437854 scopus 로고    scopus 로고
    • Caveolin-1 deficiency (-/-) conveys premalignant alterations in mammary epithelia, with abnormal lumen formation, growth factor independence, and cell invasiveness
    • DOI 10.2353/ajpath.2006.050429
    • Sotgia F, Williams TM, Schubert W, Medina F, Minetti C, et al. 2006. Caveolin-1 deficiency (-/-) conveys premalignant alterations in mammary epithelia, with abnormal lumen formation, growth factor independence, and cell invasiveness. Am. J. Pathol. 168:292-309 (Pubitemid 43062581)
    • (2006) American Journal of Pathology , vol.168 , Issue.1 , pp. 292-309
    • Sotgia, F.1    Williams, T.M.2    Schubert, W.3    Medina, F.4    Minetti, C.5    Pestell, R.G.6    Lisanti, M.P.7
  • 110
    • 1642483595 scopus 로고    scopus 로고
    • Caveolin-1 Regulates Matrix Metalloproteinases-1 Induction and CD147/EMMPRIN Cell Surface Clustering
    • DOI 10.1074/jbc.M312947200
    • Tang W, Hemler ME. 2004. Caveolin-1 regulates matrix metalloproteinase 1 induction and CD147/EMMPRIN cell surface clustering. J. Biol. Chem. 279:11112-18 (Pubitemid 38401604)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.12 , pp. 11112-11118
    • Tang, W.1    Hemler, M.E.2
  • 111
    • 49749144117 scopus 로고    scopus 로고
    • Human breast cancer-associated fibroblasts (CAFs) show caveolin-1 downregulation and RB tumor suppressor functional inactivation: Implications for the response to hormonal therapy
    • Mercier I, Casimiro MC, Wang C, Rosenberg AL, Quong J, et al. 2008. Human breast cancer-associated fibroblasts (CAFs) show caveolin-1 downregulation and RB tumor suppressor functional inactivation: implications for the response to hormonal therapy. Cancer Biol. Ther. 7:1212-25
    • (2008) Cancer Biol. Ther , vol.7 , pp. 1212-25
    • Mercier, I.1    Casimiro, M.C.2    Wang, C.3    Rosenberg, A.L.4    Quong, J.5
  • 112
    • 62549120295 scopus 로고    scopus 로고
    • Caveolin-1-/- null mammary stromal fibroblasts share characteristics with human breast cancer-associated fibroblasts
    • Sotgia F, DelGaldo F, CasimiroMC, Bonuccelli G, Mercier I, et al. 2009. Caveolin-1-/- null mammary stromal fibroblasts share characteristics with human breast cancer-associated fibroblasts. Am. J. Pathol. 174:746-61
    • (2009) Am. J. Pathol , vol.174 , pp. 746-61
    • Sotgia, F.1    Delgaldo, F.2    Casimiro, M.C.3    Bonuccelli, G.4    Mercier, I.5
  • 113
    • 77954165461 scopus 로고    scopus 로고
    • Tumor cells induce the cancer associated fibroblast phenotype via caveolin-1 degradation: Implications for breast cancer and DCIS therapy with autophagy inhibitors
    • Martinez-Outschoorn UE, Pavlides S, Whitaker-Menezes D, Daumer KM, Milliman JN, et al. 2010. Tumor cells induce the cancer associated fibroblast phenotype via caveolin-1 degradation: implications for breast cancer and DCIS therapy with autophagy inhibitors. Cell Cycle 9:2423-33
    • (2010) Cell Cycle , vol.9 , pp. 2423-33
    • Martinez-Outschoorn, U.E.1    Pavlides, S.2    Whitaker-Menezes, D.3    Daumer, K.M.4    Milliman, J.N.5
  • 114
    • 77954162846 scopus 로고    scopus 로고
    • Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: A new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells
    • Martinez-Outschoorn UE, Balliet RM, Rivadeneira DB, Chiavarina B, Pavlides S, et al. 2010. Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: a new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells. Cell Cycle 9:3256-76
    • (2010) Cell Cycle , vol.9 , pp. 3256-76
    • Martinez-Outschoorn, U.E.1    Balliet, R.M.2    Rivadeneira, D.B.3    Chiavarina, B.4    Pavlides, S.5
  • 115
    • 74849087878 scopus 로고    scopus 로고
    • The reverse Warburg effect: Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma
    • Pavlides S, Whitaker-Menezes D, Castello-Cros R, Flomenberg N, Witkiewicz AK, et al. 2009. The reverse Warburg effect: aerobic glycolysis in cancer associated fibroblasts and the tumor stroma. Cell Cycle 8:3984-4001
    • (2009) Cell Cycle , vol.8 , pp. 3984-4001
    • Pavlides, S.1    Whitaker-Menezes, D.2    Castello-Cros, R.3    Flomenberg, N.4    Witkiewicz, A.K.5
  • 116
    • 77956399968 scopus 로고    scopus 로고
    • The autophagic tumor stroma model of cancer: Role of oxidative stress and ketone production in fueling tumor cell metabolism
    • Pavlides S, Tsirigos A, Migneco G, Whitaker-Menezes D, Chiavarina B, et al. 2010. The autophagic tumor stroma model of cancer: role of oxidative stress and ketone production in fueling tumor cell metabolism. Cell Cycle 9:3485-505
    • (2010) Cell Cycle , vol.9 , pp. 3485-505
    • Pavlides, S.1    Tsirigos, A.2    Migneco, G.3    Whitaker-Menezes, D.4    Chiavarina, B.5
  • 117
    • 78349266054 scopus 로고    scopus 로고
    • The autophagic tumor stroma model of cancer -aor3-temp "battery-operated tumor growth" a simple solution to the autophagy paradox
    • Martinez-Outschoorn UE, Whitaker-Menezes D, Pavlides S, Chiavarina B, Bonuccelli G, et al. 2010. The autophagic tumor stroma model of cancer or "battery-operated tumor growth": a simple solution to the autophagy paradox. Cell Cycle 9:4297-306
    • (2010) Cell Cycle , vol.9 , pp. 4297-306
    • Martinez-Outschoorn, U.E.1    Whitaker-Menezes, D.2    Pavlides, S.3    Chiavarina, B.4    Bonuccelli, G.5
  • 119
    • 77449160135 scopus 로고    scopus 로고
    • PKM2 tyrosine phosphorylation and glutamine metabolism signal a different view of theWarburg effect
    • Dang CV. 2009. PKM2 tyrosine phosphorylation and glutamine metabolism signal a different view of theWarburg effect. Sci. Signal. 2:pe75
    • (2009) Sci. Signal , vol.2 , pp. 75
    • Dang, C.V.1
  • 120
    • 76249110471 scopus 로고    scopus 로고
    • Rethinking theWarburg effect withMyc micromanaging glutamine metabolism
    • Dang CV. 2010. Rethinking theWarburg effect withMyc micromanaging glutamine metabolism. Cancer Res. 70:859-62
    • (2010) Cancer Res. , vol.70 , pp. 859-62
    • Dang, C.V.1
  • 121
    • 79953705886 scopus 로고    scopus 로고
    • Choosing between glycolysis and oxidative phosphorylation: A tumor's dilemma?
    • Jose C, Bellance N, Rossignol R. 2011. Choosing between glycolysis and oxidative phosphorylation: a tumor's dilemma? Biochim. Biophys. Acta 1807:552-61
    • (2011) Biochim. Biophys. Acta , vol.1807 , pp. 552-61
    • Jose, C.1    Bellance, N.2    Rossignol, R.3
  • 122
    • 33846987527 scopus 로고    scopus 로고
    • Excessive superoxide anion generation plays a key role in carcinogenesis
    • Lopez-Lazaro M. 2007. Excessive superoxide anion generation plays a key role in carcinogenesis. Int. J. Cancer 120:1378-80
    • (2007) Int. J. Cancer , vol.120 , pp. 1378-80
    • Lopez-Lazaro, M.1
  • 123
    • 33745631769 scopus 로고    scopus 로고
    • 2, a necessary evil for cell signaling
    • DOI 10.1126/science.1130481
    • Rhee SG. 2006. Cell signaling. H2O2, a necessary evil for cell signaling. Science 312:1882-83 (Pubitemid 43993698)
    • (2006) Science , vol.312 , Issue.5782 , pp. 1882-1883
    • Rhee, S.G.1
  • 124
    • 66249108601 scopus 로고    scopus 로고
    • Understanding the Warburg effect: The metabolic requirements of cell proliferation
    • Vander Heiden MG, Cantley LC, Thompson CB. 2009. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 324:1029-33
    • (2009) Science , vol.324 , pp. 1029-33
    • Vander Heiden, M.G.1    Cantley, L.C.2    Thompson, C.B.3
  • 125
    • 0032859002 scopus 로고    scopus 로고
    • Impact of culture conditions, culture media volumes, and glucose content on metabolic properties of renal epithelial cell cultures: Are renal cells in tissue culture hypoxic?
    • DOI 10.1159/000016312
    • Gstraunthaler G, Seppi T, Pfaller W. 1999. Impact of culture conditions, culture media volumes, and glucose content on metabolic properties of renal epithelial cell cultures. Are renal cells in tissue culture hypoxic? Cell Physiol. Biochem. 9:150-72 (Pubitemid 29439100)
    • (1999) Cellular Physiology and Biochemistry , vol.9 , Issue.3 , pp. 150-172
    • Gstraunthaler, G.1    Seppi, T.2    Pfaller, W.3
  • 127
    • 55949125948 scopus 로고    scopus 로고
    • Rhabdomyosarcoma cells show an energy producing anabolic metabolic phenotype compared with primary myocytes
    • Fan TW, Kucia M, Jankowski K, Higashi RM, Ratajczak J, et al. 2008. Rhabdomyosarcoma cells show an energy producing anabolic metabolic phenotype compared with primary myocytes. Mol. Cancer 7:79
    • (2008) Mol. Cancer , vol.7 , pp. 79
    • Fan, T.W.1    Kucia, M.2    Jankowski, K.3    Higashi, R.M.4    Ratajczak, J.5
  • 128
    • 69849090667 scopus 로고    scopus 로고
    • IncreasedOXPHOS activity precedes rise in glycolytic rate in H-RasV12/E1A transformed fibroblasts that develop aWarburg phenotype
    • de Groof AJ, te Lindert MM, vanDommelen MM, Wu M, Willemse M, et al. 2009. IncreasedOXPHOS activity precedes rise in glycolytic rate in H-RasV12/E1A transformed fibroblasts that develop aWarburg phenotype. Mol. Cancer 8:54
    • (2009) Mol. Cancer , vol.8 , pp. 54
    • De Groof, A.J.1    Te Lindert, M.M.2    Vandommelen, M.M.3    Wu, M.4    Willemse, M.5
  • 129
    • 26944452745 scopus 로고    scopus 로고
    • Glucose metabolism heterogeneity in human and mouse malignant glioma cell lines
    • DOI 10.1007/s11060-004-6404-6
    • Griguer CE, Oliva CR, Gillespie GY. 2005. Glucose metabolism heterogeneity in human and mouse malignant glioma cell lines. J. Neurooncol. 74:123-33 (Pubitemid 41478907)
    • (2005) Journal of Neuro-Oncology , vol.74 , Issue.2 , pp. 123-133
    • Griguer, C.E.1    Oliva, C.R.2    Gillespie, G.Y.3
  • 130
    • 0842325793 scopus 로고    scopus 로고
    • Energy Substrate Modulates Mitochondrial Structure and Oxidative Capacity in Cancer Cells
    • DOI 10.1158/0008-5472.CAN-03-1101
    • Rossignol R, Gilkerson R, Aggeler R, Yamagata K, Remington SJ, Capaldi RA. 2004. Energy substrate modulates mitochondrial structure and oxidative capacity in cancer cells. Cancer Res. 64:985-93 (Pubitemid 38176901)
    • (2004) Cancer Research , vol.64 , Issue.3 , pp. 985-993
    • Rossignol, R.1    Gilkerson, R.2    Aggeler, R.3    Yamagata, K.4    Remington, S.J.5    Capaldi, R.A.6
  • 134
    • 13444283313 scopus 로고    scopus 로고
    • Ras inhibition in glioblastoma down-regulates hypoxia-inducible factor-1α, causing glycolysis shutdown and cell death
    • Blum R, Jacob-Hirsch J, Amariglio N, Rechavi G, Kloog Y. 2005. Ras inhibition in glioblastoma downregulates hypoxia-inducible factor 1α, causing glycolysis shutdown and cell death. Cancer Res. 65:999-1006 (Pubitemid 40216462)
    • (2005) Cancer Research , vol.65 , Issue.3 , pp. 999-1006
    • Blum, R.1    Jacob-Hirsch, J.2    Amariglio, N.3    Rechavi, G.4    Kloog, Y.5
  • 135
    • 0036078271 scopus 로고    scopus 로고
    • Activation of Ras cascade increases the mitochondrial enzyme content of respiratory competent yeast
    • DOI 10.1016/S0006-291X(02)00391-1, PII S0006291X02003911
    • Dejean L, Beauvoit B, Bunoust O, Guerin B, Rigoulet M. 2002. Activation of Ras cascade increases the mitochondrial enzyme content of respiratory competent yeast. Biochem. Biophys. Res. Commun. 293:1383-88 (Pubitemid 34681030)
    • (2002) Biochemical and Biophysical Research Communications , vol.293 , Issue.5 , pp. 1383-1388
    • Dejean, L.1    Beauvoit, B.2    Bunoust, O.3    Guerin, B.4    Rigoulet, M.5
  • 136
    • 43549098260 scopus 로고    scopus 로고
    • The oncogene c-Myc coordinates regulation of metabolic networks to enable rapid cell cycle entry
    • Morrish F, Neretti N, Sedivy JM, Hockenbery DM. 2008. The oncogene c-Myc coordinates regulation of metabolic networks to enable rapid cell cycle entry. Cell Cycle 7:1054-66
    • (2008) Cell Cycle , vol.7 , pp. 1054-66
    • Morrish, F.1    Neretti, N.2    Sedivy, J.M.3    Hockenbery, D.M.4
  • 137
    • 37449034854 scopus 로고    scopus 로고
    • Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
    • DeBerardinis RJ, Mancuso A, Daikhin E, Nissim I, Yudkoff M, et al. 2007. Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis. Proc. Natl. Acad. Sci. USA 104:19345-50
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 19345-50
    • Deberardinis, R.J.1    Mancuso, A.2    Daikhin, E.3    Nissim, I.4    Yudkoff, M.5
  • 138
    • 64749116346 scopus 로고    scopus 로고
    • C-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism
    • Gao P, Tchernyshyov I, Chang TC, Lee YS, Kita K, et al. 2009. c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism. Nature 458:762-65
    • (2009) Nature , vol.458 , pp. 762-65
    • Gao, P.1    Tchernyshyov, I.2    Chang, T.C.3    Lee, Y.S.4    Kita, K.5
  • 139
    • 77956497712 scopus 로고    scopus 로고
    • Targeting mitochondrial glutaminase activity inhibits oncogenic transformation
    • Wang JB, Erickson JW, Fuji R, Ramachandran S, Gao P, et al. 2010. Targeting mitochondrial glutaminase activity inhibits oncogenic transformation. Cancer Cell 18:207-19
    • (2010) Cancer Cell , vol.18 , pp. 207-19
    • Wang, J.B.1    Erickson, J.W.2    Fuji, R.3    Ramachandran, S.4    Gao, P.5
  • 140
    • 53349153184 scopus 로고    scopus 로고
    • Prognostic value of signal transducers and activators of transcription 3 in breast cancer. Cancer Epidemiol
    • Sheen-Chen SM, Huang CC, Tang RP, Chou FF, EngHL. 2008. Prognostic value of signal transducers and activators of transcription 3 in breast cancer. Cancer Epidemiol. Biomarkers Prev. 17:2286-90
    • (2008) Biomarkers Prev , vol.17 , pp. 2286-90
    • Sheen-Chen, S.M.1    Huang, C.C.2    Tang, R.P.3    Chou, F.F.4    Eng, H.L.5
  • 141
    • 70350449248 scopus 로고    scopus 로고
    • Constitutive activation of signal transducer and activator of transcription 3 in epithelial ovarian carcinoma
    • Min H, Wei-Hong Z. 2009. Constitutive activation of signal transducer and activator of transcription 3 in epithelial ovarian carcinoma. J. Obstet. Gynaecol. Res. 35:918-25
    • (2009) J. Obstet. Gynaecol. Res , vol.35 , pp. 918-25
    • Min, H.1    Wei-Hong, Z.2
  • 142
    • 68349100316 scopus 로고    scopus 로고
    • Expression of activated signal transducer and activator of transcription 3 predicts poor clinical outcome in gastric adenocarcinoma
    • Lee J, Kang WK, Park JO, Park SH, Park YS, et al. 2009. Expression of activated signal transducer and activator of transcription 3 predicts poor clinical outcome in gastric adenocarcinoma. Acta Pathol. Microbiol. Immunol. 117:598-606
    • (2009) Acta Pathol. Microbiol. Immunol , vol.117 , pp. 598-606
    • Lee, J.1    Kang, W.K.2    Park, J.O.3    Park, S.H.4    Park, Y.S.5
  • 144
    • 77749334738 scopus 로고    scopus 로고
    • Mitochondrial p32 protein is a critical regulator of tumor metabolism via maintenance of oxidative phosphorylation
    • Fogal V, Richardson AD, Karmali PP, Scheffler IE, Smith JW, Ruoslahti E. 2010. Mitochondrial p32 protein is a critical regulator of tumor metabolism via maintenance of oxidative phosphorylation. Mol. Cell. Biol. 30:1303-18
    • (2010) Mol. Cell. Biol. , vol.30 , pp. 1303-18
    • Fogal, V.1    Richardson, A.D.2    Karmali, P.P.3    Scheffler, I.E.4    Smith, J.W.5    Ruoslahti, E.6
  • 145
    • 79951725426 scopus 로고    scopus 로고
    • Mitochondrial p32/C1QBP is highly expressed in prostate cancer and is associated with shorter prostate-specific antigen relapse time after radical prostatectomy
    • Amamoto R, Yagi M, Song Y, Oda Y, Tsuneyoshi M, et al. 2011. Mitochondrial p32/C1QBP is highly expressed in prostate cancer and is associated with shorter prostate-specific antigen relapse time after radical prostatectomy. Cancer Sci. 102:639-47
    • (2011) Cancer Sci. , vol.102 , pp. 639-47
    • Amamoto, R.1    Yagi, M.2    Song, Y.3    Oda, Y.4    Tsuneyoshi, M.5
  • 146
  • 147
    • 77951255088 scopus 로고    scopus 로고
    • Expression of mitochondrial transcription factor A in endometrial carcinomas: Clinicopathologic correlations and prognostic significance
    • Toki N, Kagami S, Kurita T, Kawagoe T, Matsuura Y, et al. 2010. Expression of mitochondrial transcription factor A in endometrial carcinomas: clinicopathologic correlations and prognostic significance. Virchows Arch. 456:387-93
    • (2010) Virchows Arch. , vol.456 , pp. 387-93
    • Toki, N.1    Kagami, S.2    Kurita, T.3    Kawagoe, T.4    Matsuura, Y.5
  • 150
    • 77949323798 scopus 로고    scopus 로고
    • Incorporating the antidiabetic drug metformin in HER2-positive breast cancer treated with neo-adjuvant chemotherapy and trastuzumab: An ongoing clinical-translational research experience at the Catalan Institute of Oncology
    • Martin-Castillo B, Dorca J, Vazquez-Martin A, Oliveras-Ferraros C, Lopez-Bonet E, et al. 2010. Incorporating the antidiabetic drug metformin in HER2-positive breast cancer treated with neo-adjuvant chemotherapy and trastuzumab: an ongoing clinical-translational research experience at the Catalan Institute of Oncology. Ann. Oncol. 21:187-89
    • (2010) Ann. Oncol. , vol.21 , pp. 187-89
    • Martin-Castillo, B.1    Dorca, J.2    Vazquez-Martin, A.3    Oliveras-Ferraros, C.4    Lopez-Bonet, E.5
  • 152
    • 67749144226 scopus 로고    scopus 로고
    • Metformin and pathologic complete responses to neoadjuvant chemotherapy in diabetic patients with breast cancer
    • Jiralerspong S, Palla SL, Giordano SH, Meric-Bernstam F, Liedtke C, et al. 2009. Metformin and pathologic complete responses to neoadjuvant chemotherapy in diabetic patients with breast cancer. J. Clin. Oncol. 27:3297-302
    • (2009) J. Clin. Oncol , vol.27 , pp. 3297-302
    • Jiralerspong, S.1    Palla, S.L.2    Giordano, S.H.3    Meric-Bernstam, F.4    Liedtke, C.5
  • 153
    • 0034659785 scopus 로고    scopus 로고
    • Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain
    • DOI 10.1042/0264-6021:3480607
    • Owen MR, Doran E, Halestrap AP. 2000. Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain. Biochem. J. 348(Part 3):607-14 (Pubitemid 30410251)
    • (2000) Biochemical Journal , vol.348 , Issue.3 , pp. 607-614
    • Owen, M.R.1    Doran, E.2    Halestrap, A.P.3
  • 155
    • 77950191479 scopus 로고    scopus 로고
    • Targeting cancer cell metabolism: The combination of metformin and 2-deoxyglucose induces p53-dependent apoptosis in prostate cancer cells
    • Ben Sahra I, Laurent K, Giuliano S, Larbret F, Ponzio G, et al. 2010. Targeting cancer cell metabolism: The combination of metformin and 2-deoxyglucose induces p53-dependent apoptosis in prostate cancer cells. Cancer Res. 70:2465-75
    • (2010) Cancer Res. , vol.70 , pp. 2465-75
    • Ben Sahra, I.1    Laurent, K.2    Giuliano, S.3    Larbret, F.4    Ponzio, G.5
  • 158
    • 78651463452 scopus 로고    scopus 로고
    • Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases
    • Xu W, Yang H, Liu Y, Yang Y, Wang P, et al. 2011. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. Cancer Cell 19:17-30
    • (2011) Cancer Cell , vol.19 , pp. 17-30
    • Xu, W.1    Yang, H.2    Liu, Y.3    Yang, Y.4    Wang, P.5
  • 159
    • 64849098267 scopus 로고    scopus 로고
    • Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1α
    • Zhao S, Lin Y, Xu W, Jiang W, Zha Z, et al. 2009. Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1α. Science 324:261-65
    • (2009) Science , vol.324 , pp. 261-65
    • Zhao, S.1    Lin, Y.2    Xu, W.3    Jiang, W.4    Zha, Z.5
  • 160
    • 79952741730 scopus 로고    scopus 로고
    • Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome
    • Reitman ZJ, Jin G, Karoly ED, Spasojevic I, Yang J, et al. 2011. Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome. Proc. Natl. Acad. Sci. USA 108:3270-75
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 3270-75
    • Reitman, Z.J.1    Jin, G.2    Karoly, E.D.3    Spasojevic, I.4    Yang, J.5
  • 161
    • 18544365990 scopus 로고    scopus 로고
    • Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer
    • Tomlinson IP, Alam NA, Rowan AJ, Barclay E, Jaeger EE, et al. 2002. Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer. Nat. Genet. 30:406-10
    • (2002) Nat. Genet , vol.30 , pp. 406-10
    • Tomlinson, I.P.1    Alam, N.A.2    Rowan, A.J.3    Barclay, E.4    Jaeger, E.E.5
  • 164
  • 165
    • 77956255442 scopus 로고    scopus 로고
    • A history of mitochondrial diseases
    • Dimauro S. 2011. A history of mitochondrial diseases. J. Inherit. Metab. Dis. 34:261-76
    • (2011) J. Inherit. Metab. Dis. , vol.34 , pp. 261-76
    • Dimauro, S.1
  • 166
    • 0037972522 scopus 로고    scopus 로고
    • Mitochondrial respiratory-chain diseases
    • DOI 10.1056/NEJMra022567
    • DiMauro S, Schon EA. 2003. Mitochondrial respiratory-chain diseases. N. Engl. J. Med. 348:2656-68 (Pubitemid 36741594)
    • (2003) New England Journal of Medicine , vol.348 , Issue.26 , pp. 2656-2668
    • DiMauro, S.1    Schon, E.A.2
  • 167
    • 26944466776 scopus 로고    scopus 로고
    • The expanding phenotype of mitochondrial myopathy
    • DiMauro S, Gurgel-Giannetti J. 2005. The expanding phenotype of mitochondrial myopathy. Curr. Opin. Neurol. 18:538-42 (Pubitemid 41476139)
    • (2005) Current Opinion in Neurology , vol.18 , Issue.5 , pp. 538-542
    • DiMauro, S.1    Gurgel-Giannetti, J.2
  • 168
    • 34248215663 scopus 로고    scopus 로고
    • CoQ10 deficiency diseases in adults
    • Quinzii CM, Hirano M, DiMauro S. 2007. CoQ10 deficiency diseases in adults. Mitochondrion 7(Suppl.):122-26
    • (2007) Mitochondrion , vol.7 , Issue.SUPPL. , pp. 122-26
    • Quinzii, C.M.1    Hirano, M.2    Dimauro, S.3
  • 169
    • 77956937212 scopus 로고    scopus 로고
    • Generation of trans-mitochondrial mito-mice by the introduction of a pathogenicG13997A mtDNA from highlymetastatic lung carcinoma cells
    • Yokota M, Shitara H, Hashizume O, Ishikawa K, Nakada K, et al. Generation of trans-mitochondrial mito-mice by the introduction of a pathogenicG13997A mtDNA from highlymetastatic lung carcinoma cells. FEBS Lett. 584:3943-48
    • FEBS Lett , vol.584 , pp. 3943-48
    • Yokota, M.1    Shitara, H.2    Hashizume, O.3    Ishikawa, K.4    Nakada, K.5
  • 170
    • 77953551959 scopus 로고    scopus 로고
    • The reverse Warburg effect: Glycolysis inhibitors prevent the tumor promoting effects of caveolin-1 deficient cancer associated fibroblasts
    • Bonuccelli G, Whitaker-Menezes D, Castello-Cros R, Pavlides S, Pestell RG, et al. 2010. The reverse Warburg effect: Glycolysis inhibitors prevent the tumor promoting effects of caveolin-1 deficient cancer associated fibroblasts. Cell Cycle 9:1960-71
    • (2010) Cell Cycle , vol.9 , pp. 1960-1971
    • Bonuccelli, G.1    Whitaker-Menezes, D.2    Castello-Cros, R.3    Pavlides, S.4    Pestell, R.G.5
  • 172
    • 77954154374 scopus 로고    scopus 로고
    • Glycolytic cancer associated fibroblasts promote breast cancer tumor growth, without a measurable increase in angiogenesis: Evidence for stromal-epithelial metabolic coupling
    • Migneco G, Whitaker-Menezes D, Chiavarina B, Castello-Cros R, Pavlides S, et al. 2010. Glycolytic cancer associated fibroblasts promote breast cancer tumor growth, without a measurable increase in angiogenesis: evidence for stromal-epithelial metabolic coupling. Cell Cycle 9:2412-22
    • (2010) Cell Cycle , vol.9 , pp. 2412-22
    • Migneco, G.1    Whitaker-Menezes, D.2    Chiavarina, B.3    Castello-Cros, R.4    Pavlides, S.5
  • 173
    • 76549084854 scopus 로고    scopus 로고
    • Characterization of phosphoglycerate kinase 1 expression of stromal cells derived from tumormicroenvironment in prostate cancer progression
    • Wang J, Ying G, Jung Y, Lu J, Zhu J, et al. 2010. Characterization of phosphoglycerate kinase 1 expression of stromal cells derived from tumormicroenvironment in prostate cancer progression. Cancer Res. 70:471-80
    • (2010) Cancer Res. , vol.70 , pp. 471-80
    • Wang, J.1    Ying, G.2    Jung, Y.3    Lu, J.4    Zhu, J.5
  • 174
    • 57349135377 scopus 로고    scopus 로고
    • Phosphoglycerate kinase 1-overexpressing lung cancer cells reduce cyclooxygenase 2 expression and promote anti-tumor immunity in vivo
    • Tang SJ, Ho MY, Cho HC, Lin YC, Sun GH, et al. 2008. Phosphoglycerate kinase 1-overexpressing lung cancer cells reduce cyclooxygenase 2 expression and promote anti-tumor immunity in vivo. Int. J. Cancer 123:2840-48
    • (2008) Int. J. Cancer , vol.123 , pp. 2840-48
    • Tang, S.J.1    Ho, M.Y.2    Cho, H.C.3    Lin, Y.C.4    Sun, G.H.5
  • 175
    • 77956399348 scopus 로고    scopus 로고
    • HIF1-α functions as a tumor promoter in cancer associated fibroblasts, and as a tumor suppressor in breast cancer cells: Autophagy drives compartment-specific oncogenesis
    • Chiavarina B, Whitaker-Menezes D, Migneco G, Martinez-Outschoorn UE, Pavlides S, et al. 2010. HIF1-α functions as a tumor promoter in cancer associated fibroblasts, and as a tumor suppressor in breast cancer cells: Autophagy drives compartment-specific oncogenesis. Cell Cycle 9:3534-51
    • (2010) Cell Cycle , vol.9 , pp. 3534-51
    • Chiavarina, B.1    Whitaker-Menezes, D.2    Migneco, G.3    Martinez-Outschoorn, U.E.4    Pavlides, S.5
  • 176
    • 77956419439 scopus 로고    scopus 로고
    • Ketones and lactate "fuel" tumor growth and metastasis: Evidence that epithelial cancer cells use oxidative mitochondrial metabolism
    • Bonuccelli G, Tsirigos A, Whitaker-Menezes D, Pavlides S, Pestell RG, et al. 2010. Ketones and lactate "fuel" tumor growth and metastasis: evidence that epithelial cancer cells use oxidative mitochondrial metabolism. Cell Cycle 9:3506-14
    • (2010) Cell Cycle , vol.9 , pp. 3506-14
    • Bonuccelli, G.1    Tsirigos, A.2    Whitaker-Menezes, D.3    Pavlides, S.4    Pestell, R.G.5
  • 178
    • 77950672300 scopus 로고    scopus 로고
    • Lactate-dehydrogenase 5 is overexpressed in non-small cell lung cancer and correlates with the expression of the transketolase-like protein 1
    • Kayser G, Kassem A, SienelW, Schulte-Uentrop L, Mattern D, et al. 2010. Lactate-dehydrogenase 5 is overexpressed in non-small cell lung cancer and correlates with the expression of the transketolase-like protein 1. Diagn. Pathol. 5:22
    • (2010) Diagn. Pathol. , vol.5 , pp. 22
    • Kayser, G.1    Kassem, A.2    Sienel, W.3    Schulte-Uentrop, L.4    Mattern, D.5
  • 179
    • 0141730410 scopus 로고    scopus 로고
    • Lactate dehydrogenase-5 (LDH-5) overexpression in non-small-cell lung cancer tissues is linked to tumour hypoxia, angiogenic factor production and poor prognosis
    • DOI 10.1038/sj.bjc.6601205
    • Koukourakis MI, Giatromanolaki A, Sivridis E, Bougioukas G, Didilis V, et al. 2003. Lactate dehydrogenase 5 (LDH-5) overexpression in non-small-cell lung cancer tissues is linked to tumour hypoxia, angiogenic factor production and poor prognosis. Br. J. Cancer 89:877-85 (Pubitemid 37175811)
    • (2003) British Journal of Cancer , vol.89 , Issue.5 , pp. 877-885
    • Koukourakis, M.I.1    Giatromanolaki, A.2    Sivridis, E.3    Bougioukas, G.4    Didilis, V.5    Gatter, K.C.6    Harris, A.L.7
  • 180
    • 0033964315 scopus 로고    scopus 로고
    • Tumor grade, microvessel density, and activities of malate dehydrogenase, lactate dehydrogenase, and hexokinase in squamous cell carcinoma
    • Ross CD, Gomaa MA, Gillies E, Juengel R, Medina JE. 2000. Tumor grade, microvessel density, and activities of malate dehydrogenase, lactate dehydrogenase, and hexokinase in squamous cell carcinoma. Otolaryngol. Head Neck Surg. 122:195-200 (Pubitemid 30086138)
    • (2000) Otolaryngology - Head and Neck Surgery , vol.122 , Issue.2 , pp. 195-200
    • Ross, C.D.1    Gomaa, M.A.2    Gillies, E.3    Juengel, R.4    Medina, J.E.5
  • 181
    • 70449673054 scopus 로고    scopus 로고
    • Lactate dehydrogenase 5 expression in squamous cell head and neck cancer relates to prognosis following radical or postoperative radiotherapy
    • Koukourakis MI, Giatromanolaki A, Winter S, Leek R, Sivridis E, Harris AL. 2009. Lactate dehydrogenase 5 expression in squamous cell head and neck cancer relates to prognosis following radical or postoperative radiotherapy. Oncology 77:285-92
    • (2009) Oncology , vol.77 , pp. 285-92
    • Koukourakis, M.I.1    Giatromanolaki, A.2    Winter, S.3    Leek, R.4    Sivridis, E.5    Harris, A.L.6
  • 182
    • 33749027749 scopus 로고    scopus 로고
    • Lactate dehydrogenase 5 expression in operable colorectal cancer: Strong association with survival and activated vascular endothelial growth factor pathway - A report of the tumour angiogenesis research group
    • DOI 10.1200/JCO.2006.05.9501
    • Koukourakis MI, Giatromanolaki A, Sivridis E, Gatter KC, Harris AL. 2006. Lactate dehydrogenase 5 expression in operable colorectal cancer: strong association with survival and activated vascular endothelial growth factor pathway-a report of the Tumour Angiogenesis Research Group. J. Clin. Oncol. 24:4301-8 (Pubitemid 46630788)
    • (2006) Journal of Clinical Oncology , vol.24 , Issue.26 , pp. 4301-4308
    • Koukourakis, M.I.1    Giatromanolaki, A.2    Sivridis, E.3    Gatter, K.C.4    Harris, A.L.5
  • 183
    • 33751430258 scopus 로고    scopus 로고
    • Lactate dehydrogenase 5 (LDH-5) expression in endometrial cancer relates to the activated VEGF/VEGFR2(KDR) pathway and prognosis
    • DOI 10.1016/j.ygyno.2006.05.043, PII S0090825806004392
    • Giatromanolaki A, Sivridis E, Gatter KC, Turley H, Harris AL, Koukourakis MI. 2006. Lactate dehydrogenase 5 (LDH-5) expression in endometrial cancer relates to the activated VEGF/VEGFR2(KDR) pathway and prognosis. Gynecol. Oncol. 103:912-18 (Pubitemid 44821314)
    • (2006) Gynecologic Oncology , vol.103 , Issue.3 , pp. 912-918
    • Giatromanolaki, A.1    Sivridis, E.2    Gatter, K.C.3    Turley, H.4    Harris, A.L.5    Koukourakis, M.I.6
  • 184
    • 34347231995 scopus 로고    scopus 로고
    • Expression of glucose transporter-1, hexokinase-II, proliferating cell nuclear antigen and survival of patients with pancreatic cancer
    • DOI 10.1080/07357900701208931, PII 779065232
    • Lyshchik A, Higashi T, Hara T, Nakamoto Y, Fujimoto K, et al. 2007. Expression of glucose transporter 1, hexokinase II, proliferating cell nuclear antigen and survival of patients with pancreatic cancer. Cancer Investig. 25:154-62 (Pubitemid 47164858)
    • (2007) Cancer Investigation , vol.25 , Issue.3 , pp. 154-162
    • Lyshchik, A.1    Higashi, T.2    Hara, T.3    Nakamoto, Y.4    Fujimoto, K.5    Doi, R.6    Imamura, M.7    Saga, T.8    Togashi, K.9
  • 185
    • 79251539264 scopus 로고    scopus 로고
    • The level of glycolyticmetabolism in acute myeloid leukemia blasts at diagnosis is prognostic for clinical outcome
    • Herst PM, Howman RA, Neeson PJ, Berridge MV, Ritchie DS. 2011. The level of glycolyticmetabolism in acute myeloid leukemia blasts at diagnosis is prognostic for clinical outcome. J. Leukoc. Biol. 89:51-55
    • (2011) J. Leukoc. Biol. , vol.89 , pp. 51-55
    • Herst, P.M.1    Howman, R.A.2    Neeson, P.J.3    Berridge, M.V.4    Ritchie, D.S.5
  • 186
    • 57449097020 scopus 로고    scopus 로고
    • Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice
    • Sonveaux P, Vegran F, Schroeder T, Wergin MC, Verrax J, et al. 2008. Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice. J. Clin. Investig. 118:3930-42
    • (2008) J. Clin. Investig , vol.118 , pp. 3930-42
    • Sonveaux, P.1    Vegran, F.2    Schroeder, T.3    Wergin, M.C.4    Verrax, J.5
  • 187
    • 0031731913 scopus 로고    scopus 로고
    • Glucose and lactate metabolism in C6 glioma cells: Evidence for the preferential utilization of lactate for cell oxidative metabolism
    • DOI 10.1159/000017328
    • Bouzier AK, Voisin P, Goodwin R, Canioni P, Merle M. 1998. Glucose and lactate metabolism in C6 glioma cells: evidence for the preferential utilization of lactate for cell oxidative metabolism. Dev. Neurosci. 20:331-38 (Pubitemid 28495527)
    • (1998) Developmental Neuroscience , vol.20 , Issue.4-5 , pp. 331-338
    • Bouzier, A.-K.1    Voisin, P.2    Goodwin, R.3    Canioni, P.4    Merle, M.5
  • 188
    • 31544445490 scopus 로고    scopus 로고
    • Comparison of metabolic pathways between cancer cells and stromal cells in colorectal carcinomas: A metabolic survival role for tumor-associated stroma
    • DOI 10.1158/0008-5472.CAN-05-3260
    • Koukourakis MI, Giatromanolaki A, Harris AL, Sivridis E. 2006. Comparison of metabolic pathways between cancer cells and stromal cells in colorectal carcinomas: a metabolic survival role for tumorassociated stroma. Cancer Res. 66:632-37 (Pubitemid 43165922)
    • (2006) Cancer Research , vol.66 , Issue.2 , pp. 632-637
    • Koukourakis, M.I.1    Giatromanolaki, A.2    Harris, A.L.3    Sivridis, E.4
  • 189
    • 0030320546 scopus 로고    scopus 로고
    • 18F-2-deoxyglucose signal in PET activation studies
    • Magistretti PJ, Pellerin L. 1996. The contribution of astrocytes to the 18F-2-deoxyglucose signal in PET activation studies. Mol. Psychiatry 1:445-52 (Pubitemid 126439784)
    • (1996) Molecular Psychiatry , vol.1 , Issue.6 , pp. 445-452
    • Magistretti, P.J.1    Pellerin, L.2
  • 190
    • 33745988312 scopus 로고    scopus 로고
    • Neuron-glia metabolic coupling and plasticity
    • DOI 10.1242/jeb.02208
    • Magistretti PJ. 2006. Neuron-glia metabolic coupling and plasticity. J. Exp. Biol. 209:2304-11 (Pubitemid 44065524)
    • (2006) Journal of Experimental Biology , vol.209 , Issue.12 , pp. 2304-2311
    • Magistretti, P.J.1
  • 191
    • 70349579720 scopus 로고    scopus 로고
    • Role of glutamate in neuron-glia metabolic coupling.Am
    • Magistretti PJ. 2009. Role of glutamate in neuron-glia metabolic coupling.Am. J. Clin.Nutr. 90:875-80S
    • (2009) J. Clin.Nutr , vol.90
    • Magistretti, P.J.1
  • 192
  • 193
    • 34347208367 scopus 로고    scopus 로고
    • Metabolic compartmentalization in the human cortex and hippocampus: Evidence for a cell- and region-specific localization of lactate dehydrogenase 5 and pyruvate dehydrogenase
    • Laughton JD, Bittar P, Charnay Y, Pellerin L, Kovari E, et al. 2007. Metabolic compartmentalization in the human cortex and hippocampus: evidence for a cell- and region-specific localization of lactate dehydrogenase 5 and pyruvate dehydrogenase. BMC Neurosci. 8:35
    • (2007) BMC Neurosci , vol.8 , pp. 35
    • Laughton, J.D.1    Bittar, P.2    Charnay, Y.3    Pellerin, L.4    Kovari, E.5
  • 194
    • 3042793425 scopus 로고    scopus 로고
    • Neural activity triggers neuronal oxidative metabolism followed by astrocytic glycolysis
    • DOI 10.1126/science.1096485
    • Kasischke KA, Vishwasrao HD, Fisher PJ, Zipfel WR, Webb WW. 2004. Neural activity triggers neuronal oxidative metabolism followed by astrocytic glycolysis. Science 305:99-103 (Pubitemid 38869381)
    • (2004) Science , vol.305 , Issue.5680 , pp. 99-103
    • Kasischke, K.A.1    Vishwasrao, H.D.2    Fisher, P.J.3    Zipfel, W.R.4    Webb, W.W.5
  • 195
    • 77956400210 scopus 로고    scopus 로고
    • Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia HIF1 induction and NFκB activation in the tumor stromal microenvironment
    • Martinez-Outschoorn UE, Trimmer C, Lin Z, Whitaker-Menezes D, Chiavarina B, et al. 2010. Autophagy in cancer associated fibroblasts promotes tumor cell survival: role of hypoxia, HIF1 induction and NFκB activation in the tumor stromal microenvironment. Cell Cycle 9:3515-33
    • (2010) Cell Cycle , vol.9 , pp. 3515-33
    • Martinez-Outschoorn, U.E.1    Trimmer, C.2    Lin, Z.3    Whitaker-Menezes, D.4    Chiavarina, B.5
  • 196
    • 67651183782 scopus 로고    scopus 로고
    • Vascular caveolin deficiency supports the angiogenic effects of nitrite, a major end product of nitric oxide metabolism in tumors
    • Frerart F, Lobysheva I, Gallez B, Dessy C, Feron O. 2009. Vascular caveolin deficiency supports the angiogenic effects of nitrite, a major end product of nitric oxide metabolism in tumors. Mol. Cancer Res. 7:1056-63
    • (2009) Mol. Cancer Res , vol.7 , pp. 1056-63
    • Frerart, F.1    Lobysheva, I.2    Gallez, B.3    Dessy, C.4    Feron, O.5
  • 197
    • 78649736380 scopus 로고    scopus 로고
    • The regulatory role of nitric oxide in proinflammatory cytokine expression during the induction and resolution of inflammation
    • Kobayashi Y. 2010. The regulatory role of nitric oxide in proinflammatory cytokine expression during the induction and resolution of inflammation. J. Leukoc. Biol. 88:1157-62
    • (2010) J. Leukoc. Biol. , vol.88 , pp. 1157-62
    • Kobayashi, Y.1
  • 198
    • 0035477926 scopus 로고    scopus 로고
    • Nitric oxide inhibits mitochondrial NADH:ubiquinone reductase activity through peroxynitrite formation
    • DOI 10.1042/0264-6021:3590139
    • Riobo NA, Clementi E, Melani M, Boveris A, Cadenas E, et al. 2001. Nitric oxide inhibits mitochondrial NADH:ubiquinone reductase activity through peroxynitrite formation. Biochem. J. 359:139-45 (Pubitemid 32939215)
    • (2001) Biochemical Journal , vol.359 , Issue.1 , pp. 139-145
    • Riobo, N.A.1    Clementi, E.2    Melani, M.3    Boveris, A.4    Cadenas, E.5    Moncada, S.6    Poderoso, J.J.7
  • 199
    • 77953560003 scopus 로고    scopus 로고
    • Loss of stromal caveolin-1 leads to oxidative stress mimics hypoxia and drives inflammation in the tumor microenvironment conferring the "reverse Warburg effect": A transcriptional informatics analysis with validation
    • Pavlides S, Tsirigos A, Vera I, Flomenberg N, Frank PG, et al. 2010. Loss of stromal caveolin-1 leads to oxidative stress, mimics hypoxia and drives inflammation in the tumor microenvironment, conferring the "reverse Warburg effect": a transcriptional informatics analysis with validation. Cell Cycle 9:2201-19
    • (2010) Cell Cycle , vol.9 , pp. 2201-19
    • Pavlides, S.1    Tsirigos, A.2    Vera, I.3    Flomenberg, N.4    Frank, P.G.5
  • 200
    • 77953472763 scopus 로고    scopus 로고
    • Integrinβ1β1 regulates epidermal growth factor receptor activation by controlling peroxisome proliferator-activated receptorα- dependent caveolin-1 expression
    • Chen X, WhitingC, Borza C, Hu W, Mont S, et al. 2010. Integrinβ1β1 regulates epidermal growth factor receptor activation by controlling peroxisome proliferator-activated receptorα-dependent caveolin-1 expression. Mol. Cell. Biol. 30:3048-58
    • (2010) Mol. Cell. Biol. , vol.30 , pp. 3048-58
    • Chen, X.1    Whitingc Borza, C.2    Hu, W.3    Mont, S.4
  • 202
    • 14744270462 scopus 로고    scopus 로고
    • Caveolin-1 expression is essential for proper nonshivering thermogenesis in brown adipose tissue
    • DOI 10.2337/diabetes.54.3.679
    • Cohen AW, Schubert W, Brasaemle DL, Scherer PE, Lisanti MP. 2005. Caveolin-1 expression is essential for proper nonshivering thermogenesis in brown adipose tissue. Diabetes 54:679-86 (Pubitemid 40326265)
    • (2005) Diabetes , vol.54 , Issue.3 , pp. 679-686
    • Cohen, A.W.1    Schubert, W.2    Brasaemle, D.L.3    Scherer, P.E.4    Lisanti, M.P.5
  • 205
    • 79951833645 scopus 로고    scopus 로고
    • Caveolin-1 and mitochondrial SOD2 (MnSOD) function as tumor suppressors in the stromal microenvironment: A new genetically tractable model for human cancer associated fibroblasts
    • Trimmer C, Sotgia F, Whitaker-Menezes D, Balliet RM, Eaton G, et al. 2011. Caveolin-1 and mitochondrial SOD2 (MnSOD) function as tumor suppressors in the stromal microenvironment: a new genetically tractable model for human cancer associated fibroblasts. Cancer Biol. Ther. 11:383-94
    • (2011) Cancer Biol. Ther. , vol.11 , pp. 383-94
    • Trimmer, C.1    Sotgia, F.2    Whitaker-Menezes, D.3    Balliet, R.M.4    Eaton, G.5
  • 206
    • 77954600493 scopus 로고    scopus 로고
    • Oxidative stress promotes myofibroblast differentiation and tumour spreading
    • Toullec A, Gerald D, Despouy G, Bourachot B, Cardon M, et al. 2010. Oxidative stress promotes myofibroblast differentiation and tumour spreading. EMBO Mol. Med. 2:211-30
    • (2010) EMBO Mol. Med. , vol.2 , pp. 211-30
    • Toullec, A.1    Gerald, D.2    Despouy, G.3    Bourachot, B.4    Cardon, M.5
  • 207
    • 77957234116 scopus 로고    scopus 로고
    • NOX4-dependent ROS production by stromal mammary cells modulates epithelial MCF-7 cell migration
    • Tobar N, Guerrero J, Smith PC, Martinez J. 2010. NOX4-dependent ROS production by stromal mammary cells modulates epithelial MCF-7 cell migration. Br. J. Cancer 103:1040-47
    • (2010) Br. J. Cancer , vol.103 , pp. 1040-47
    • Tobar, N.1    Guerrero, J.2    Smith, P.C.3    Martinez, J.4
  • 208
    • 79952179447 scopus 로고    scopus 로고
    • ROS signaling by NOX4 drives fibroblast-to-myofibroblast differentiation in the diseased prostatic stroma
    • Sampson N, Koziel R, Zenzmaier C, Bubendorf L, Plas E, et al. 2011. ROS signaling by NOX4 drives fibroblast-to-myofibroblast differentiation in the diseased prostatic stroma. Mol. Endocrinol. 25:503-15
    • (2011) Mol. Endocrinol. , vol.25 , pp. 503-15
    • Sampson, N.1    Koziel, R.2    Zenzmaier, C.3    Bubendorf, L.4    Plas, E.5
  • 209
    • 26244432793 scopus 로고    scopus 로고
    • Proliferating fibroblasts at the invading tumour edge of colorectal adenocarcinomas are associated with endogenous markers of hypoxia, acidity, and oxidative stress
    • DOI 10.1136/jcp.2005.026260
    • Sivridis E, Giatromanolaki A, Koukourakis MI. 2005. Proliferating fibroblasts at the invading tumour edge of colorectal adenocarcinomas are associated with endogenous markers of hypoxia, acidity, and oxidative stress. J. Clin. Pathol. 58:1033-38 (Pubitemid 41416051)
    • (2005) Journal of Clinical Pathology , vol.58 , Issue.10 , pp. 1033-1038
    • Sivridis, E.1    Giatromanolaki, A.2    Koukourakis, M.I.3
  • 210
    • 33644874424 scopus 로고    scopus 로고
    • Expression of hypoxia-inducible factor 1αand its downstream targets in fibroepithelial tumors of the breast
    • Kuijper A, van der Groep P, van der Wall E, van Diest PJ. 2005. Expression of hypoxia-inducible factor 1αand its downstream targets in fibroepithelial tumors of the breast. Breast Cancer Res. 7:R808-18
    • (2005) Breast Cancer Res , vol.7
    • Kuijper, A.1    Van Der Groep, P.2    Van Der Wall, E.3    Van Diest, P.J.4
  • 211
    • 67649198500 scopus 로고    scopus 로고
    • Prognostic significance of carbonic anhydrase IX expression by cancer-associated fibroblasts in lung adenocarcinoma
    • Nakao M, Ishii G, Nagai K, Kawase A, Kenmotsu H, et al. 2009. Prognostic significance of carbonic anhydrase IX expression by cancer-associated fibroblasts in lung adenocarcinoma. Cancer 115:2732-43
    • (2009) Cancer , vol.115 , pp. 2732-43
    • Nakao, M.1    Ishii, G.2    Nagai, K.3    Kawase, A.4    Kenmotsu, H.5
  • 212
    • 34249815207 scopus 로고    scopus 로고
    • Stromal expression of hypoxia regulated proteins is an adverse prognostic factor in colorectal carcinomas
    • Cleven AH, van Engeland M, Wouters BG, de Bruine AP. 2007. Stromal expression of hypoxia regulated proteins is an adverse prognostic factor in colorectal carcinomas. Cell Oncol. 29:229-40 (Pubitemid 46855703)
    • (2007) Cellular Oncology , vol.29 , Issue.3 , pp. 229-240
    • Cleven, A.H.G.1    Van Engeland, M.2    Wouters, B.G.3    De Bruine, A.P.4
  • 213
    • 77954667202 scopus 로고    scopus 로고
    • Deregulation of HIF1-α and hypoxia-regulated pathways in hepatocellular carcinoma and corresponding non-malignant liver tissue- influence of a modulated host stroma on the prognosis of HCC
    • Simon F, Bockhorn M, Praha C, Baba HA, Broelsch CE, et al. 2010. Deregulation of HIF1-α and hypoxia-regulated pathways in hepatocellular carcinoma and corresponding non-malignant liver tissue- influence of a modulated host stroma on the prognosis of HCC. Langenbecks Arch. Surg. 395:395-405
    • (2010) Langenbecks Arch. Surg. , vol.395 , pp. 395-405
    • Simon, F.1    Bockhorn, M.2    Praha, C.3    Baba, H.A.4    Broelsch, C.E.5
  • 214
    • 9344221090 scopus 로고    scopus 로고
    • Inhibition of metastatic tumor growth in mouse lung by repeated administration of polyethylene glycol-conjugated catalase: Quantitative analysis with firefly luciferase-expressing melanoma cells
    • DOI 10.1158/1078-0432.CCR-04-1020
    • Hyoudou K, Nishikawa M, Umeyama Y, Kobayashi Y, Yamashita F, Hashida M. 2004. Inhibition of metastatic tumor growth in mouse lung by repeated administration of polyethylene glycol-conjugated catalase: quantitative analysiswith firefly luciferase-expressing melanoma cells. Clin. Cancer Res. 10:7685-91 (Pubitemid 39557533)
    • (2004) Clinical Cancer Research , vol.10 , Issue.22 , pp. 7685-7691
    • Hyoudou, K.1    Nishikawa, M.2    Umeyama, Y.3    Kobayashi, Y.4    Yamashita, F.5    Hashida, M.6
  • 215
    • 28444496658 scopus 로고    scopus 로고
    • Inhibition of metastatic tumor growth by targeted delivery of antioxidant enzymes
    • DOI 10.1016/j.jconrel.2005.09.017, PII S0168365905004839
    • Nishikawa M, Hyoudou K, Kobayashi Y, Umeyama Y, Takakura Y, Hashida M. 2005. Inhibition of metastatic tumor growth by targeted delivery of antioxidant enzymes. J. Control. Release 109:101-7 (Pubitemid 41737256)
    • (2005) Journal of Controlled Release , vol.109 , Issue.1-3 , pp. 101-107
    • Nishikawa, M.1    Hyoudou, K.2    Kobayashi, Y.3    Umeyama, Y.4    Takakura, Y.5    Hashida, M.6
  • 217
    • 64149085276 scopus 로고    scopus 로고
    • Catalase delivery for inhibiting ROS-mediated tissue injury and tumor metastasis
    • Nishikawa M, Hashida M, Takakura Y. 2009. Catalase delivery for inhibiting ROS-mediated tissue injury and tumor metastasis. Adv. Drug Deliv. Rev. 61:319-26
    • (2009) Adv. Drug Deliv. Rev , vol.61 , pp. 319-26
    • Nishikawa, M.1    Hashida, M.2    Takakura, Y.3
  • 218
    • 67349205391 scopus 로고    scopus 로고
    • Prevention of pulmonary metastasis from subcutaneous tumors by binary system-based sustained delivery of catalase
    • Hyoudou K, Nishikawa M, Ikemura M, Kobayashi Y, Mendelsohn A, et al. 2009. Prevention of pulmonary metastasis from subcutaneous tumors by binary system-based sustained delivery of catalase. J. Control. Release 137:110-15
    • (2009) J. Control. Release , vol.137 , pp. 110-15
    • Hyoudou, K.1    Nishikawa, M.2    Ikemura, M.3    Kobayashi, Y.4    Mendelsohn, A.5
  • 222
    • 0035881315 scopus 로고    scopus 로고
    • Overexpression of manganese superoxide dismutase suppresses tumor formation by modulation of activator protein-1 signaling in a multistage skin carcinogenesis model
    • Zhao Y, Xue Y, Oberley TD, Kiningham KK, Lin SM, et al. 2001. Overexpression of manganese superoxide dismutase suppresses tumor formation by modulation of activator protein 1 signaling in a multistage skin carcinogenesis model. Cancer Res. 61:6082-88 (Pubitemid 32762543)
    • (2001) Cancer Research , vol.61 , Issue.16 , pp. 6082-6088
    • Zhao, Y.1    Xue, Y.2    Oberley, T.D.3    Kiningham, K.K.4    Lin, S.-M.5    Yen, H.-C.6    Majima, H.7    Hines, J.8    St. Clair, D.9
  • 224
    • 66349121718 scopus 로고    scopus 로고
    • Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains
    • Bellot G, Garcia-Medina R, Gounon P, Chiche J, Roux D, et al. 2009. Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains. Mol. Cell. Biol. 29:2570-81
    • (2009) Mol. Cell. Biol , vol.29 , pp. 2570-81
    • Bellot, G.1    Garcia-Medina, R.2    Gounon, P.3    Chiche, J.4    Roux, D.5
  • 225
    • 43649104579 scopus 로고    scopus 로고
    • Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia
    • Zhang H, Bosch-Marce M, Shimoda LA, Tan YS, Baek JH, et al. 2008. Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia. J. Biol. Chem. 283:10892-903
    • (2008) J. Biol. Chem , vol.283 , pp. 10892-903
    • Zhang, H.1    Bosch-Marce, M.2    Shimoda, L.A.3    Tan, Y.S.4    Baek, J.H.5
  • 226
    • 66349095388 scopus 로고    scopus 로고
    • Quantitative metabolome profiling of colon and stomach cancer microenvironment by capillary electrophoresis time-of-flight mass spectrometry
    • Hirayama A, Kami K, Sugimoto M, Sugawara M, Toki N, et al. 2009. Quantitative metabolome profiling of colon and stomach cancer microenvironment by capillary electrophoresis time-of-flight mass spectrometry. Cancer Res. 69:4918-25
    • (2009) Cancer Res , vol.69 , pp. 4918-25
    • Hirayama, A.1    Kami, K.2    Sugimoto, M.3    Sugawara, M.4    Toki, N.5
  • 227
    • 33845314350 scopus 로고    scopus 로고
    • Mass spectrometry-based metabolic profiling reveals different metabolite patterns in invasive ovarian carcinomas and ovarian borderline tumors
    • DOI 10.1158/0008-5472.CAN-06-0755
    • Denkert C, Budczies J, Kind T, Weichert W, Tablack P, et al. 2006. Mass spectrometry-based metabolic profiling reveals different metabolite patterns in invasive ovarian carcinomas and ovarian borderline tumors. Cancer Res. 66:10795-804 (Pubitemid 44876975)
    • (2006) Cancer Research , vol.66 , Issue.22 , pp. 10795-10804
    • Denkert, C.1    Budczies, J.2    Kind, T.3    Weichert, W.4    Tablack, P.5    Sehouli, J.6    Niesporek, S.7    Konsgen, D.8    Dietel, M.9    Fiehn, O.10
  • 228
    • 60149091657 scopus 로고    scopus 로고
    • Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression
    • Sreekumar A, Poisson LM, Rajendiran TM, Khan AP, Cao Q, et al. 2009. Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature 457:910-14
    • (2009) Nature , vol.457 , pp. 910-14
    • Sreekumar, A.1    Poisson, L.M.2    Rajendiran, T.M.3    Khan, A.P.4    Cao, Q.5
  • 229
    • 58649108064 scopus 로고    scopus 로고
    • Myocardial interstitial Cajal-like cells (ICLC) in caveolin-1 KO mice
    • Gherghiceanu M, Hinescu ME, Popescu LM. 2009. Myocardial interstitial Cajal-like cells (ICLC) in caveolin-1 KO mice. J. Cell Mol. Med. 13:202-6
    • (2009) J. Cell Mol. Med , vol.13 , pp. 202-6
    • Gherghiceanu, M.1    Hinescu, M.E.2    Popescu, L.M.3
  • 230
    • 77955876472 scopus 로고    scopus 로고
    • The lipoatrophic caveolin-1 deficient mouse model reveals autophagy in mature adipocytes
    • Le Lay S, Briand N, Blouin CM, Chateau D, Prado C, et al. 2010. The lipoatrophic caveolin-1 deficient mouse model reveals autophagy in mature adipocytes. Autophagy 6:754-63
    • (2010) Autophagy , vol.6 , pp. 754-63
    • Le Lay, S.1    Briand, N.2    Blouin, C.M.3    Chateau, D.4    Prado, C.5
  • 231
    • 70350575440 scopus 로고    scopus 로고
    • Modulation of intracellular ROS levels byTIGAR controls autophagy
    • Bensaad K, Cheung EC, Vousden KH. 2009. Modulation of intracellular ROS levels byTIGAR controls autophagy. EMBO J. 28:3015-26
    • (2009) EMBO J , vol.28 , pp. 3015-26
    • Bensaad, K.1    Cheung, E.C.2    Vousden, K.H.3
  • 233
    • 77954225200 scopus 로고    scopus 로고
    • Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity
    • Zhao Y, Yang J, Liao W, Liu X, Zhang H, et al. 2010. Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity. Nat. Cell Biol. 12:665-75
    • (2010) Nat. Cell Biol. , vol.12 , pp. 665-75
    • Zhao, Y.1    Yang, J.2    Liao, W.3    Liu, X.4    Zhang, H.5
  • 234
    • 62449287501 scopus 로고    scopus 로고
    • The paradox of autophagy and its implication in cancer etiology and therapy
    • Eisenberg-Lerner A, Kimchi A. 2009. The paradox of autophagy and its implication in cancer etiology and therapy. Apoptosis 14:376-91
    • (2009) Apoptosis , vol.14 , pp. 376-91
    • Eisenberg-Lerner, A.1    Kimchi, A.2
  • 235
    • 0026709013 scopus 로고
    • Detection of frequent allelic loss on proximal chromosome 17q in sporadic breast carcinoma using microsatellite length polymorphisms
    • Futreal PA, Soderkvist P, Marks JR, Iglehart JD, CochranC, et al. 1992. Detection of frequent allelic loss on proximal chromosome 17q in sporadic breast carcinoma using microsatellite length polymorphisms. Cancer Res. 52:2624-27
    • (1992) Cancer Res , vol.52 , pp. 2624-27
    • Futreal, P.A.1    Soderkvist, P.2    Marks, J.R.3    Iglehart, J.D.4    Cochran, C.5
  • 236
    • 0027217756 scopus 로고
    • Detailed deletion mapping of chromosome 17q in ovarian and breast cancers: 2-cM Region on 17q21.3 often and commonly deleted in tumors
    • SaitoH, Inazawa J, Saito S, Kasumi F, Koi S, et al. 1993. Detailed deletion mapping of chromosome 17q in ovarian and breast cancers: 2-cM region on 17q21.3 often and commonly deleted in tumors. Cancer Res. 53:3382-85 (Pubitemid 23223313)
    • (1993) Cancer Research , vol.53 , Issue.14 , pp. 3382-3385
    • Saito, H.1    Inazawa, J.2    Saito, S.3    Kasumi, F.4    Koi, S.5    Sagae, S.6    Kudo, R.7    Saito, J.8    Noda, K.9    Nakamura, Y.10
  • 237
    • 77954242444 scopus 로고    scopus 로고
    • Autophagy-active beclin-1 correlates with favourable clinical outcome in non-Hodgkin lymphomas
    • Nicotra G, Mercalli F, Peracchio C, Castino R, Follo C, et al. 2010. Autophagy-active beclin-1 correlates with favourable clinical outcome in non-Hodgkin lymphomas. Mod. Pathol. 23:937-50
    • (2010) Mod. Pathol. , vol.23 , pp. 937-50
    • Nicotra, G.1    Mercalli, F.2    Peracchio, C.3    Castino, R.4    Follo, C.5
  • 238
    • 65249180744 scopus 로고    scopus 로고
    • The expression of beclin 1 is associated with favorable prognosis in stage IIIB colon cancers
    • Li BX, Li CY, Peng RQ, Wu XJ, Wang HY, et al. 2009. The expression of beclin 1 is associated with favorable prognosis in stage IIIB colon cancers. Autophagy 5:303-6
    • (2009) Autophagy , vol.5 , pp. 303-6
    • Li, B.X.1    Li, C.Y.2    Peng, R.Q.3    Wu, X.J.4    Wang, H.Y.5
  • 239
    • 56449107131 scopus 로고    scopus 로고
    • Association of autophagy defect with a malignant phenotype and poor prognosis of hepatocellular carcinoma
    • Ding ZB, Shi YH, Zhou J, Qiu SJ, Xu Y, et al. 2008. Association of autophagy defect with a malignant phenotype and poor prognosis of hepatocellular carcinoma. Cancer Res. 68:9167-75
    • (2008) Cancer Res , vol.68 , pp. 9167-75
    • Ding, Z.B.1    Shi, Y.H.2    Zhou, J.3    Qiu, S.J.4    Xu, Y.5
  • 240
    • 33846882638 scopus 로고    scopus 로고
    • BNIP3 as a progression marker in primary human breast cancer opposing functions in in situ versus invasive cancer
    • DOI 10.1158/1078-0432.CCR-06-1466
    • Tan EY, Campo L, Han C, Turley H, Pezzella F, et al. 2007. BNIP3 as a progression marker in primary human breast cancer; opposing functions in in situ versus invasive cancer. Clin. Cancer Res. 13:467-74 (Pubitemid 46225351)
    • (2007) Clinical Cancer Research , vol.13 , Issue.I2 , pp. 467-474
    • Ern, Y.T.1    Campo, L.2    Han, C.3    Turley, H.4    Pezzella, F.5    Gatter, K.C.6    Harris, A.L.7    Fox, S.B.8
  • 241
    • 66449099090 scopus 로고    scopus 로고
    • Autophagy suppresses tumorigenesis through elimination of p62
    • Mathew R, Karp CM, Beaudoin B, Vuong N, Chen G, et al. 2009. Autophagy suppresses tumorigenesis through elimination of p62. Cell 137:1062-75
    • (2009) Cell , vol.137 , pp. 1062-75
    • Mathew, R.1    Karp, C.M.2    Beaudoin, B.3    Vuong, N.4    Chen, G.5
  • 242
    • 56249119507 scopus 로고    scopus 로고
    • Overexpression and altered subcellular localization of autophagy-related 16-like 1 in human oral squamous-cell carcinoma: Correlation with lymphovascular invasion and lymph-node metastasis
    • Nomura H, Uzawa K, Yamano Y, Fushimi K, Ishigami T, et al. 2009. Overexpression and altered subcellular localization of autophagy-related 16-like 1 in human oral squamous-cell carcinoma: correlation with lymphovascular invasion and lymph-node metastasis. Hum. Pathol. 40:83-91
    • (2009) Hum. Pathol , vol.40 , pp. 83-91
    • Nomura, H.1    Uzawa, K.2    Yamano, Y.3    Fushimi, K.4    Ishigami, T.5
  • 243
    • 53049084066 scopus 로고    scopus 로고
    • Epithelial and stromal cathepsin K and CXCL14 expression in breast tumor progression
    • Kleer CG, Bloushtain-Qimron N, Chen YH, Carrasco D, Hu M, et al. 2008. Epithelial and stromal cathepsin K and CXCL14 expression in breast tumor progression. Clin. Cancer Res. 14:5357-67
    • (2008) Clin. Cancer Res , vol.14 , pp. 5357-67
    • Kleer, C.G.1    Bloushtain-Qimron, N.2    Chen, Y.H.3    Carrasco, D.4    Hu, M.5
  • 244
    • 0029808255 scopus 로고    scopus 로고
    • Cathepsin D in host stromal cells, but not in tumor cells, is associated with aggressive behavior in node-negative breast cancer
    • DOI 10.1016/S0046-8177(96)90214-2
    • Nadji M, Fresno M, Nassiri M, Conner G, Herrero A, Morales AR. 1996. Cathepsin D in host stromal cells, but not in tumor cells, is associated with aggressive behavior in node-negative breast cancer. Hum. Pathol. 27:890-95 (Pubitemid 26304566)
    • (1996) Human Pathology , vol.27 , Issue.9 , pp. 890-895
    • Nadji, M.1    Fresno, M.2    Nassiri, M.3    Conner, G.4    Herrero, A.5    Morales, A.R.6
  • 246
    • 0037018405 scopus 로고    scopus 로고
    • Caveolin-1 inhibits anchorage-independent growth, anoikis and invasiveness in MCF-7 human breast cancer cells
    • DOI 10.1038/sj/onc/1205300
    • Fiucci G, Ravid D, Reich R, Liscovitch M. 2002. Caveolin-1 inhibits anchorage-independent growth, anoikis and invasiveness in MCF-7 human breast cancer cells. Oncogene 21:2365-75 (Pubitemid 34413560)
    • (2002) Oncogene , vol.21 , Issue.15 , pp. 2365-2375
    • Fiucci, G.1    Ravid, D.2    Reich, R.3    Liscovitch, M.4
  • 247
    • 0345736990 scopus 로고    scopus 로고
    • Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of β-catenin, and enhanced tumor cell invasion
    • DOI 10.1016/S1535-6108(03)00304-0
    • Lu Z, Ghosh S, Wang Z, Hunter T. 2003. Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of α-catenin, and enhanced tumor cell invasion. Cancer Cell 4:499-515 (Pubitemid 38050046)
    • (2003) Cancer Cell , vol.4 , Issue.6 , pp. 499-515
    • Lu, Z.1    Ghosh, S.2    Wang, Z.3    Hunter, T.4
  • 248
    • 7644227012 scopus 로고    scopus 로고
    • Caveolin-1 inhibits breast cancer growth and metastasis
    • DOI 10.1038/sj.onc.1208062
    • Sloan EK, Stanley KL, Anderson RL. 2004. Caveolin-1 inhibits breast cancer growth and metastasis. Oncogene 23:7893-97 (Pubitemid 39457039)
    • (2004) Oncogene , vol.23 , Issue.47 , pp. 7893-7897
    • Sloan, E.K.1    Stanley, K.L.2    Anderson, R.L.3
  • 249
    • 0031758918 scopus 로고    scopus 로고
    • Genes encoding human caveolin-1 and -2 are co-localized to the D7S522 locus (7q31.1), a known fragile site (FRA7G) that is frequently deleted in human cancers
    • DOI 10.1016/S0014-5793(98)01134-X, PII S001457939801134X
    • Engelman JA, Zhang XL, Lisanti MP. 1998. Genes encoding human caveolin-1 and -2 are co-localized to the D7S522 locus (7q31.1), a known fragile site (FRA7G) that is frequently deleted in human cancers. FEBS Lett. 436:403-10 (Pubitemid 28482971)
    • (1998) FEBS Letters , vol.436 , Issue.3 , pp. 403-410
    • Engelman, J.A.1    Zhang, X.L.2    Lisanti, M.P.3
  • 251
    • 4043107128 scopus 로고    scopus 로고
    • Mutation and aberrant expression of caveolin-1 in human oral squamous cell carcinomas and oral cancer cell lines
    • Han SE, Park KH, Lee G, Huh YJ, Min BM. 2004. Mutation and aberrant expression of caveolin-1 in human oral squamous cell carcinomas and oral cancer cell lines. Int. J. Oncol. 24:435-40
    • (2004) Int. J. Oncol , vol.24 , pp. 435-40
    • Han, S.E.1    Park, K.H.2    Lee, G.3    Huh, Y.J.4    Min, B.M.5
  • 253
    • 78650684121 scopus 로고    scopus 로고
    • Mutational profile of the CAV-1 gene in breast cancer cases in the ethnic Kashmiri population
    • Syeed N, Husain SA, Abdullah S, Sameer AS, Chowdri NA, et al. 2010. Mutational profile of the CAV-1 gene in breast cancer cases in the ethnic Kashmiri population. Asian Pac. J. Cancer Prev. 11:1099-105
    • (2010) Asian Pac. J. Cancer Prev. , vol.11 , pp. 1099-105
    • Syeed, N.1    Husain, S.A.2    Abdullah, S.3    Sameer, A.S.4    Chowdri, N.A.5
  • 255
    • 77956845619 scopus 로고    scopus 로고
    • Absence of the caveolin-1 P132L mutation in cancers of the breast and other organs
    • Koike S, Kodera Y, Nakao A, Iwata H, Yatabe Y. 2010. Absence of the caveolin-1 P132L mutation in cancers of the breast and other organs. J. Mol. Diagn. 12:712-17
    • (2010) J. Mol. Diagn. , vol.12 , pp. 712-17
    • Koike, S.1    Kodera, Y.2    Nakao, A.3    Iwata, H.4    Yatabe, Y.5
  • 256
    • 65649133092 scopus 로고    scopus 로고
    • Caveolin-1 (P132L), a common breast cancer mutation, confers mammary cell invasiveness and defines a novel stem cell/metastasis-associated gene signature
    • Bonuccelli G, Casimiro MC, Sotgia F, Wang C, Liu M, et al. 2009. Caveolin-1 (P132L), a common breast cancer mutation, confers mammary cell invasiveness and defines a novel stem cell/metastasis-associated gene signature. Am. J. Pathol. 174:1650-62
    • (2009) Am. J. Pathol , vol.174 , pp. 1650-62
    • Bonuccelli, G.1    Casimiro, M.C.2    Sotgia, F.3    Wang, C.4    Liu, M.5
  • 257
    • 72249116890 scopus 로고    scopus 로고
    • Lipid rafts and caveolin-1 are required for invadopodia formation and extracellular matrix degradation by human breast cancer cells
    • Yamaguchi H, Takeo Y, Yoshida S, Kouchi Z, Nakamura Y, Fukami K. 2009. Lipid rafts and caveolin-1 are required for invadopodia formation and extracellular matrix degradation by human breast cancer cells. Cancer Res. 69:8594-602
    • (2009) Cancer Res , vol.69 , pp. 8594-602
    • Yamaguchi, H.1    Takeo, Y.2    Yoshida, S.3    Kouchi, Z.4    Nakamura, Y.5    Fukami, K.6
  • 259
    • 3142583075 scopus 로고    scopus 로고
    • Impact of caveolin-1 expression on clinicopathological parameters in renal cell carcinoma
    • DOI 10.1097/01.ju.0000130943.23317.08
    • Horiguchi A, Asano T, Asakuma J, Sumitomo M, Hayakawa M. 2004. Impact of caveolin-1 expression on clinicopathological parameters in renal cell carcinoma. J. Urol. 172:718-22 (Pubitemid 38900248)
    • (2004) Journal of Urology , vol.172 , Issue.2 , pp. 718-722
    • Horiguchi, A.1    Asano, T.2    Asakuma, J.3    Asano, T.4    Sumitomo, M.5    Hayakawa, M.6
  • 260
    • 34247637684 scopus 로고    scopus 로고
    • Immunohistochemical Analysis with Multiple Antibodies in Search of Prognostic Markers for Clear Cell Renal Cell Carcinoma
    • DOI 10.1016/j.urology.2007.01.069, PII S0090429507001355
    • Phuoc NB, Ehara H, Gotoh T, Nakano M, Yokoi S, et al. 2007. Immunohistochemical analysis with multiple antibodies in search of prognosticmarkers for clear cell renal cell carcinoma. Urology 69:843-48 (Pubitemid 46670242)
    • (2007) Urology , vol.69 , Issue.5 , pp. 843-848
    • Phuoc, N.B.1    Ehara, H.2    Gotoh, T.3    Nakano, M.4    Yokoi, S.5    Deguchi, T.6    Hirose, Y.7
  • 261
    • 0348013440 scopus 로고    scopus 로고
    • Caveolin-1 overexpression predicts poor disease-free survival of patients with clinically confined renal cell carcinoma
    • DOI 10.1038/sj.bjc.6601359
    • Campbell L, Gumbleton M, Griffiths DF. 2003. Caveolin-1 overexpression predicts poor disease-free survival of patients with clinically confined renal cell carcinoma. Br. J. Cancer 89:1909-13 (Pubitemid 37533269)
    • (2003) British Journal of Cancer , vol.89 , Issue.10 , pp. 1909-1913
    • Campbell, L.1    Gumbleton, M.2    Griffiths, D.F.R.3
  • 262
    • 40349100358 scopus 로고    scopus 로고
    • Combined expression of caveolin-1 and an activated AKT/mTOR pathway predicts reduced disease-free survival in clinically confined renal cell carcinoma
    • DOI 10.1038/sj.bjc.6604243, PII 6604243
    • Campbell L, Jasani B, Edwards K, Gumbleton M, Griffiths DF. 2008. Combined expression of caveolin-1 and an activated AKT/mTOR pathway predicts reduced disease-free survival in clinically confined renal cell carcinoma. Br. J. Cancer 98:931-40 (Pubitemid 351341603)
    • (2008) British Journal of Cancer , vol.98 , Issue.5 , pp. 931-940
    • Campbell, L.1    Jasani, B.2    Edwards, K.3    Gumbleton, M.4    Griffiths, D.F.R.5
  • 263
    • 0033571471 scopus 로고    scopus 로고
    • Caveolin-1 expression in clinically confined human prostate cancer: A novel prognostic marker
    • Yang G, Truong LD, Wheeler TM, Thompson TC. 1999. Caveolin-1 expression in clinically confined human prostate cancer: a novel prognostic marker. Cancer Res. 59:5719-23
    • (1999) Cancer Res , vol.59 , pp. 5719-23
    • Yang, G.1    Truong, L.D.2    Wheeler, T.M.3    Thompson, T.C.4
  • 264
    • 0037369151 scopus 로고    scopus 로고
    • Caveolin-1 expression is a predictor of recurrence-free survival in pT2NO prostate carcinoma diagnosed in Japanese patients
    • DOI 10.1002/cncr.11198
    • Satoh T, Yang G, Egawa S, Addai J, Frolov A, et al. 2003. Caveolin-1 expression is a predictor of recurrence-free survival in pT2N0 prostate carcinoma diagnosed in Japanese patients. Cancer 97:1225-33 (Pubitemid 36237308)
    • (2003) Cancer , vol.97 , Issue.5 , pp. 1225-1233
    • Satoh, T.1    Yang, G.2    Egawa, S.3    Addai, J.4    Frolov, A.5    Kuwao, S.6    Timme, T.L.7    Baba, S.8    Thompson, T.C.9
  • 265
    • 37549016730 scopus 로고    scopus 로고
    • Caveolin-1 expression is significantly associated with drug resistance and poor prognosis in advanced non-small cell lung cancer patients treated with gemcitabine-based chemotherapy
    • Ho CC, Kuo SH, Huang PH, Huang HY, Yang CH, Yang PC. 2008. Caveolin-1 expression is significantly associated with drug resistance and poor prognosis in advanced non-small cell lung cancer patients treated with gemcitabine-based chemotherapy. Lung Cancer 59:105-10
    • (2008) Lung Cancer , vol.59 , pp. 105-10
    • Ho, C.C.1    Kuo, S.H.2    Huang, P.H.3    Huang, H.Y.4    Yang, C.H.5    Yang, P.C.6
  • 266
    • 0037083622 scopus 로고    scopus 로고
    • Overexpression of caveolin-1 in esophageal squamous cell carcinoma correlates with lymph node metastasis and pathologic stage
    • DOI 10.1002/cncr.10329
    • Kato K, Hida Y, Miyamoto M, Hashida H, Shinohara T, et al. 2002. Overexpression of caveolin-1 in esophageal squamous cell carcinoma correlates with lymph node metastasis and pathologic stage. Cancer 94:929-33 (Pubitemid 34150846)
    • (2002) Cancer , vol.94 , Issue.4 , pp. 929-933
    • Kato, K.1    Hida, Y.2    Miyamoto, M.3    Hashida, H.4    Shinohara, T.5    Itoh, T.6    Okushiba, S.7    Kondo, S.8    Katoh, H.9
  • 267
    • 38449093572 scopus 로고    scopus 로고
    • The overexpression of caveolin-1 and caveolin-2 correlates with a poor prognosis and tumor progression in esophageal squamous cell carcinoma
    • Ando T, Ishiguro H, Kimura M, Mitsui A, Mori Y, et al. 2007. The overexpression of caveolin-1 and caveolin-2 correlates with a poor prognosis and tumor progression in esophageal squamous cell carcinoma. Oncol. Rep. 18:601-9
    • (2007) Oncol. Rep , vol.18 , pp. 601-9
    • Ando, T.1    Ishiguro, H.2    Kimura, M.3    Mitsui, A.4    Mori, Y.5
  • 270
    • 34247105338 scopus 로고    scopus 로고
    • Expression of caveolin-1 in mucoepidermoid carcinoma of the salivary glands: Correlation with vascular endothelial growth factor, microvessel density, and clinical outcome
    • DOI 10.1002/cncr.22573
    • Shi L, Chen XM, Wang L, Zhang L, Chen Z. 2007. Expression of caveolin-1 in mucoepidermoid carcinoma of the salivary glands: correlation with vascular endothelial growth factor, microvessel density, and clinical outcome. Cancer 109:1523-31 (Pubitemid 46595687)
    • (2007) Cancer , vol.109 , Issue.8 , pp. 1523-1531
    • Shi, L.1    Chen, X.-M.2    Wang, L.3    Zhang, L.4    Chen, Z.5
  • 272
    • 77954786261 scopus 로고    scopus 로고
    • Increased caveolin-1 expression associated with prolonged overall survival rate in hepatocellular carcinoma
    • Yang SF, Yang JY, Huang CH, Wang SN, Lu CP, et al. 2010. Increased caveolin-1 expression associated with prolonged overall survival rate in hepatocellular carcinoma. Pathology 42:438-45
    • (2010) Pathology , vol.42 , pp. 438-45
    • Yang, S.F.1    Yang, J.Y.2    Huang, C.H.3    Wang, S.N.4    Lu, C.P.5
  • 273
    • 0034667394 scopus 로고    scopus 로고
    • Caveolin-1 levels are down-regulated in human colon tumors, and ectopic expression of caveolin-1 in colon carcinoma cell lines reduces cell tumorigenicity
    • Bender FC, Reymond MA, Bron C, Quest AF. 2000. Caveolin-1 levels are down-regulated in human colon tumors, and ectopic expression of caveolin-1 in colon carcinoma cell lines reduces cell tumorigenicity. Cancer Res. 60:5870-78
    • (2000) Cancer Res , vol.60 , pp. 5870-78
    • Bender, F.C.1    Reymond, M.A.2    Bron, C.3    Quest, A.F.4
  • 274
    • 0032484149 scopus 로고    scopus 로고
    • Up-regulation of caveolae and caveolar constituents in multidrug- resistant cancer cells
    • DOI 10.1074/jbc.273.49.32380
    • Lavie Y, Fiucci G, Liscovitch M. 1998. Up-regulation of caveolae and caveolar constituents in multidrugresistant cancer cells. J. Biol. Chem. 273:32380-83 (Pubitemid 28557607)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.49 , pp. 32380-32383
    • Lavie, Y.1    Fiucci, G.2    Liscovitch, M.3
  • 277
    • 0035860690 scopus 로고    scopus 로고
    • Palmitoylation of caveolin-1 at a single site (Cys-156) controls its coupling to the c-Src tyrosine kinase: Targeting of dually acylated molecules (GPI-linked, transmembrane, or cytoplasmic) to caveolae effectively uncouples c-Src and caveolin-1 (TYR-14)
    • Lee H, Woodman SE, Engelman JA, Volonte D, Galbiati F, et al. 2001. Palmitoylation of caveolin-1 at a single site (Cys-156) controls its coupling to the c-Src tyrosine kinase: targeting of dually acylated molecules (GPI-linked, transmembrane, or cytoplasmic) to caveolae effectively uncouples c-Src and caveolin-1 (TYR-14). J. Biol. Chem. 276:35150-58
    • (2001) J. Biol. Chem , vol.276 , pp. 35150-58
    • Lee, H.1    Woodman, S.E.2    Engelman, J.A.3    Volonte, D.4    Galbiati, F.5
  • 278
    • 54249141543 scopus 로고    scopus 로고
    • Phosphorylated caveolin-1 regulates Rho/ROCK-dependent focal adhesion dynamics and tumor cell migration and invasion
    • Joshi B, Strugnell SS, Goetz JG, Kojic LD, Cox ME, et al. 2008. Phosphorylated caveolin-1 regulates Rho/ROCK-dependent focal adhesion dynamics and tumor cell migration and invasion. Cancer Res. 68:8210-20
    • (2008) Cancer Res , vol.68 , pp. 8210-20
    • Joshi, B.1    Strugnell, S.S.2    Goetz, J.G.3    Kojic, L.D.4    Cox, M.E.5
  • 279
    • 0035830831 scopus 로고    scopus 로고
    • Caveolin-1 binding to endoplasmic reticulum membranes and entry into the regulated secretory pathway are regulated by serine phosphorylation. Protein sorting at the level of the endoplasmic reticulum
    • Schlegel A, Arvan P, Lisanti MP. 2001. Caveolin-1 binding to endoplasmic reticulum membranes and entry into the regulated secretory pathway are regulated by serine phosphorylation. Protein sorting at the level of the endoplasmic reticulum. J. Biol. Chem. 276:4398-408
    • (2001) J. Biol. Chem , vol.276 , pp. 4398-408
    • Schlegel, A.1    Arvan, P.2    Lisanti, M.P.3
  • 281
    • 77049121544 scopus 로고    scopus 로고
    • Analysis of cyclins A, B1, D1 and e in breast cancer in relation to tumor grade and other prognostic factors
    • Bostrom P, Soderstrom M, Palokangas T, Vahlberg T, Collan Y, et al. 2009. Analysis of cyclins A, B1, D1 and E in breast cancer in relation to tumor grade and other prognostic factors. BMC Res. Notes 2:140
    • (2009) BMC Res. Notes , vol.2 , pp. 140
    • Bostrom, P.1    Soderstrom, M.2    Palokangas, T.3    Vahlberg, T.4    Collan, Y.5
  • 283
    • 0037337631 scopus 로고    scopus 로고
    • Loss of MCT1, MCT3, and MCT4 expression in the retinal pigment epithelium and neural retina of the 5A11/basigin-null mouse
    • DOI 10.1167/iovs.02-0552
    • Philp NJ, Ochrietor JD, Rudoy C, Muramatsu T, Linser PJ. 2003. Loss of MCT1, MCT3, and MCT4 expression in the retinal pigment epithelium and neural retina of the 5A11/basigin-null mouse. Investig. Ophthalmol. Vis. Sci. 44:1305-11 (Pubitemid 36297854)
    • (2003) Investigative Ophthalmology and Visual Science , vol.44 , Issue.3 , pp. 1305-1311
    • Philp, N.J.1    Ochrietor, J.D.2    Rudoy, C.3    Muramatsu, T.4    Linser, P.J.5
  • 284
    • 33846910806 scopus 로고    scopus 로고
    • Is lactate food for neurons? Comparison of monocarboxylate transporter subtypes in brain and muscle
    • DOI 10.1016/j.neuroscience.2006.11.062, PII S0306452206016460
    • Bergersen LH. 2007. Is lactate food for neurons? Comparison of monocarboxylate transporter subtypes in brain and muscle. Neuroscience 145:11-19 (Pubitemid 46237686)
    • (2007) Neuroscience , vol.145 , Issue.1 , pp. 11-19
    • Bergersen, L.H.1
  • 285
    • 0025888968 scopus 로고
    • Current concepts in lactate exchange
    • Brooks GA. 1991. Current concepts in lactate exchange. Med. Sci. Sports
    • (1991) Med. Sci. Sports Exerc , vol.23 , pp. 895-906
    • Brooks, G.A.1
  • 286
    • 0036545332 scopus 로고    scopus 로고
    • Lactate shuttles in nature
    • Brooks GA. 2002. Lactate shuttles in nature. Biochem. Soc. Trans. 30:258-64
    • (2002) Biochem. Soc. Trans , vol.30 , pp. 258-64
    • Brooks, G.A.1
  • 287
    • 34247862319 scopus 로고    scopus 로고
    • Lactate: Link between glycolytic and oxidative metabolism
    • Brooks GA. 2007. Lactate: link between glycolytic and oxidative metabolism. Sports Med. 37:341-43 (Pubitemid 46698534)
    • (2007) Sports Medicine , vol.37 , Issue.4-5 , pp. 341-343
    • Brooks, G.A.1
  • 288
    • 39749181643 scopus 로고    scopus 로고
    • A lactatic perspective on metabolism
    • Gladden LB. 2008. A lactatic perspective on metabolism. Med. Sci. Sports Exerc. 40:477-85
    • (2008) Med. Sci. Sports Exerc , vol.40 , pp. 477-85
    • Gladden, L.B.1
  • 289
    • 23844526132 scopus 로고    scopus 로고
    • Immunohistochemical analysis of MCT1, MCT2 and MCT4 expression in rat plantaris muscle
    • DOI 10.1113/jphysiol.2005.087411
    • Hashimoto T, Masuda S, Taguchi S, Brooks GA. 2005. Immunohistochemical analysis ofMCT1, MCT2 and MCT4 expression in rat plantaris muscle. J. Physiol. 567:121-29 (Pubitemid 41167310)
    • (2005) Journal of Physiology , vol.567 , Issue.1 , pp. 121-129
    • Hashimoto, T.1    Masuda, S.2    Taguchi, S.3    Brooks, G.A.4
  • 291
    • 58049208254 scopus 로고    scopus 로고
    • Malarial infection develops mitochondrial pathology and mitochondrial oxidative stress to promote hepatocyte apoptosis
    • Dey S, Guha M, Alam A, Goyal M, Bindu S, et al. 2009. Malarial infection develops mitochondrial pathology and mitochondrial oxidative stress to promote hepatocyte apoptosis. Free Radic. Biol. Med. 46:271-81
    • (2009) Free Radic. Biol. Med , vol.46 , pp. 271-81
    • Dey, S.1    Guha, M.2    Alam, A.3    Goyal, M.4    Bindu, S.5
  • 292
    • 77957338789 scopus 로고    scopus 로고
    • Oxidative stress and immunesuppression in Toxoplasma gondii positive blood donors: Implications for safe blood transfusion
    • Elsheikha HM, El-Motayam MH, Abouel-Nour MF, Morsy AT. 2009. Oxidative stress and immunesuppression in Toxoplasma gondii positive blood donors: implications for safe blood transfusion. J. Egypt. Soc. Parasitol. 39:421-28
    • (2009) J. Egypt. Soc. Parasitol , vol.39 , pp. 421-28
    • Elsheikha, H.M.1    El-Motayam, M.H.2    Abouel-Nour, M.F.3    Morsy, A.T.4
  • 293
    • 63149088988 scopus 로고    scopus 로고
    • Malondialdehyde, glutathione, and nitric oxide levels in Toxoplasma gondii seropositive patients
    • Karaman U, Celik T, Kiran TR, Colak C, Daldal NU. 2008. Malondialdehyde, glutathione, and nitric oxide levels in Toxoplasma gondii seropositive patients. Korean J. Parasitol. 46:293-95
    • (2008) Korean J. Parasitol , vol.46 , pp. 293-95
    • Karaman, U.1    Celik, T.2    Kiran, T.R.3    Colak, C.4    Daldal, N.U.5
  • 294
    • 77952518968 scopus 로고    scopus 로고
    • Phenyl-α-tert-butyl-nitrone and benzonidazole treatment controlled the mitochondrial oxidative stress and evolution of cardiomyopathy in chronic chagasic rats
    • Wen JJ, Gupta S, Guan Z, Dhiman M, Condon D, et al. 2010. Phenyl-α-tert-butyl-nitrone and benzonidazole treatment controlled the mitochondrial oxidative stress and evolution of cardiomyopathy in chronic chagasic rats. J. Am. Coll Cardiol. 55:2499-508
    • (2010) J. Am. Coll Cardiol. , vol.55 , pp. 2499-508
    • Wen, J.J.1    Gupta, S.2    Guan, Z.3    Dhiman, M.4    Condon, D.5
  • 295
    • 58149398242 scopus 로고    scopus 로고
    • The autophagic pathway is a key component in the lysosomal dependent entry of Trypanosoma cruzi into the host cell
    • Romano PS, ArboitMA, Vazquez CL, ColomboMI. 2009. The autophagic pathway is a key component in the lysosomal dependent entry of Trypanosoma cruzi into the host cell. Autophagy 5:6-18
    • (2009) Autophagy , vol.5 , pp. 6-18
    • Romano, P.S.1    Arboit, M.A.2    Vazquez, C.L.3    Colombo, M.I.4
  • 298
    • 66549103618 scopus 로고    scopus 로고
    • Clinical and translational implications of the caveolin gene family: Lessons from mouse models and human genetic disorders
    • Mercier I, Jasmin JF, Pavlides S, Minetti C, Flomenberg N, et al. 2009. Clinical and translational implications of the caveolin gene family: lessons from mouse models and human genetic disorders. Lab. Investig. 89:614-23
    • (2009) Lab. Investig , vol.89 , pp. 614-23
    • Mercier, I.1    Jasmin, J.F.2    Pavlides, S.3    Minetti, C.4    Flomenberg, N.5
  • 299
    • 79957927705 scopus 로고    scopus 로고
    • Molecular profiling of a lethal tumor microenvironment, as defined by stromal caveolin-1 status in breast cancers
    • Witkiewicz AK, Kline J, Queenan M, Brody JR, Tsirigos A, et al. 2011. Molecular profiling of a lethal tumor microenvironment, as defined by stromal caveolin-1 status in breast cancers. Cell Cycle 10:1794-809
    • (2011) Cell Cycle , vol.10 , pp. 1794-809
    • Witkiewicz, A.K.1    Kline, J.2    Queenan, M.3    Brody, J.R.4    Tsirigos, A.5
  • 300
    • 79954537559 scopus 로고    scopus 로고
    • Ketones and lactate increase cancer cell "stemness, " driving recurrence, metastasis, and poor clinical outcome in breast cancer: Achieving personalized medicine via metabolo-genomics
    • Martinez-Outschoorn UE, Prisco M, Ertel A, Tsirigos A, Lin Z, et al. 2011. Ketones and lactate increase cancer cell "stemness, " driving recurrence, metastasis, and poor clinical outcome in breast cancer: achieving personalized medicine via metabolo-genomics. Cell Cycle 10:1271-86
    • (2011) Cell Cycle , vol.10 , pp. 1271-86
    • Martinez-Outschoorn, U.E.1    Prisco, M.2    Ertel, A.3    Tsirigos, A.4    Lin, Z.5


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