메뉴 건너뛰기




Volumn 36, Issue 1, 2015, Pages 111-119

Erratum: SMAD4 and its role in pancreatic cancer (Tumour Biol. (2015) 36:1 (111-119) DOI: 10.1007/s13277-014-2883-z);SMAD4 and its role in pancreatic cancer

Author keywords

Loss of SMAD4; Pancreatic cancer; Prognosis; TGF signaling pathway

Indexed keywords

SMAD4 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; SMAD4 PROTEIN, HUMAN;

EID: 84925500887     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.3233/TUB-229004     Document Type: Erratum
Times cited : (80)

References (94)
  • 1
    • 79959837073 scopus 로고    scopus 로고
    • Major molecular markers in pancreatic ductal adenocarcinoma and their roles in screening, diagnosis, prognosis, and treatment
    • PID: 21673535
    • Singh P, Srinivasan R, Wig JD. Major molecular markers in pancreatic ductal adenocarcinoma and their roles in screening, diagnosis, prognosis, and treatment. Pancreas. 2011;40:644–52.
    • (2011) Pancreas , vol.40 , pp. 644-652
    • Singh, P.1    Srinivasan, R.2    Wig, J.D.3
  • 2
    • 80355137867 scopus 로고    scopus 로고
    • Transforming growth factor beta in pancreatic cancer
    • COI: 1:CAS:528:DC%2BC38XovV2gsA%3D%3D, PID: 21619533
    • Hilbig A, Oettle H. Transforming growth factor beta in pancreatic cancer. Curr Pharm Biotechnol. 2011;12:2158–64.
    • (2011) Curr Pharm Biotechnol , vol.12 , pp. 2158-2164
    • Hilbig, A.1    Oettle, H.2
  • 3
    • 34547903586 scopus 로고    scopus 로고
    • Validation of the 6th edition AJCC pancreatic cancer staging system: report from the National Cancer Database
    • PID: 17580363
    • Bilimoria KY, Bentrem DJ, Ko CY, Ritchey J, Stewart AK, et al. Validation of the 6th edition AJCC pancreatic cancer staging system: report from the National Cancer Database. Cancer. 2007;110:738–44.
    • (2007) Cancer , vol.110 , pp. 738-744
    • Bilimoria, K.Y.1    Bentrem, D.J.2    Ko, C.Y.3    Ritchey, J.4    Stewart, A.K.5
  • 4
    • 0032812487 scopus 로고    scopus 로고
    • Progress in cancer genetics: lessons from pancreatic cancer
    • PID: 10436774
    • Goggins M, Kern SE, Offerhaus JA, Hruban RH. Progress in cancer genetics: lessons from pancreatic cancer. Ann Oncol. 1999;10 Suppl 4:4–8.
    • (1999) Ann Oncol , vol.10 , pp. 4-8
    • Goggins, M.1    Kern, S.E.2    Offerhaus, J.A.3    Hruban, R.H.4
  • 5
    • 1842481404 scopus 로고    scopus 로고
    • Missense mutations of MADH4: characterization of the mutational hot spot and functional consequences in human tumors
    • COI: 1:CAS:528:DC%2BD2cXhvFClsb8%3D, PID: 15014009
    • Iacobuzio-Donahue CA, Song J, Parmiagiani G, Yeo CJ, Hruban RH, et al. Missense mutations of MADH4: characterization of the mutational hot spot and functional consequences in human tumors. Clin Cancer Res. 2004;10:1597–604.
    • (2004) Clin Cancer Res , vol.10 , pp. 1597-1604
    • Iacobuzio-Donahue, C.A.1    Song, J.2    Parmiagiani, G.3    Yeo, C.J.4    Hruban, R.H.5
  • 6
    • 84907482266 scopus 로고    scopus 로고
    • SMAD4 regulates cell motility through transcription of N-cadherin in human pancreatic ductal epithelium
    • PID: 25264609
    • Kang Y, Ling J, Suzuki R, Roife D, Chopin-Laly X, et al. SMAD4 regulates cell motility through transcription of N-cadherin in human pancreatic ductal epithelium. PLoS One. 2014;9:e107948.
    • (2014) PLoS One , vol.9 , pp. e107948
    • Kang, Y.1    Ling, J.2    Suzuki, R.3    Roife, D.4    Chopin-Laly, X.5
  • 7
    • 84897950936 scopus 로고    scopus 로고
    • Molecular pathology of pancreatic cancer
    • COI: 1:CAS:528:DC%2BC2cXhsFakur0%3D, PID: 24471965
    • Saiki Y, Horii A. Molecular pathology of pancreatic cancer. Pathol Int. 2014;64:10–9.
    • (2014) Pathol Int , vol.64 , pp. 10-19
    • Saiki, Y.1    Horii, A.2
  • 8
    • 0034785348 scopus 로고    scopus 로고
    • TGF-beta signaling in tumor suppression and cancer progression
    • COI: 1:CAS:528:DC%2BD3MXnsFKgt7c%3D, PID: 11586292
    • Derynck R, Akhurst RJ, Balmain A. TGF-beta signaling in tumor suppression and cancer progression. Nat Genet. 2001;29:117–29.
    • (2001) Nat Genet , vol.29 , pp. 117-129
    • Derynck, R.1    Akhurst, R.J.2    Balmain, A.3
  • 9
    • 0142104985 scopus 로고    scopus 로고
    • Smad-dependent and Smad-independent pathways in TGF-beta family signalling
    • COI: 1:CAS:528:DC%2BD3sXnvV2hs7c%3D, PID: 14534577
    • Derynck R, Zhang YE. Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature. 2003;425:577–84.
    • (2003) Nature , vol.425 , pp. 577-584
    • Derynck, R.1    Zhang, Y.E.2
  • 11
    • 0030593038 scopus 로고    scopus 로고
    • DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1
    • COI: 1:CAS:528:DyaK28XlsFartg%3D%3D, PID: 8553070
    • Hahn SA, Schutte M, Hoque AT, Moskaluk CA, da Costa LT, et al. DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science. 1996;271:350–3.
    • (1996) Science , vol.271 , pp. 350-353
    • Hahn, S.A.1    Schutte, M.2    Hoque, A.T.3    Moskaluk, C.A.4    da Costa, L.T.5
  • 12
    • 0028940853 scopus 로고
    • Genetic characterization and cloning of mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster
    • COI: 1:CAS:528:DyaK28XhsFSrurw%3D, PID: 7768443
    • Sekelsky JJ, Newfeld SJ, Raftery LA, Chartoff EH, Gelbart WM. Genetic characterization and cloning of mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster. Genetics. 1995;139:1347–58.
    • (1995) Genetics , vol.139 , pp. 1347-1358
    • Sekelsky, J.J.1    Newfeld, S.J.2    Raftery, L.A.3    Chartoff, E.H.4    Gelbart, W.M.5
  • 13
    • 16144366751 scopus 로고    scopus 로고
    • Nomenclature: vertebrate mediators of TGFbeta family signals
    • COI: 1:CAS:528:DyaK28XmsVGhs7Y%3D, PID: 8861901
    • Derynck R, Gelbart WM, Harland RM, Heldin CH, Kern SE, et al. Nomenclature: vertebrate mediators of TGFbeta family signals. Cell. 1996;87:173.
    • (1996) Cell , vol.87 , pp. 173
    • Derynck, R.1    Gelbart, W.M.2    Harland, R.M.3    Heldin, C.H.4    Kern, S.E.5
  • 14
    • 80054000870 scopus 로고    scopus 로고
    • The Smad family and its role in pancreatic cancer
    • COI: 1:STN:280:DC%2BC3MfktVWmtA%3D%3D, PID: 21921337
    • Singh P, Wig JD, Srinivasan R. The Smad family and its role in pancreatic cancer. Indian J Cancer. 2011;48:351–60.
    • (2011) Indian J Cancer , vol.48 , pp. 351-360
    • Singh, P.1    Wig, J.D.2    Srinivasan, R.3
  • 15
    • 0034614708 scopus 로고    scopus 로고
    • Structural basis of Smad2 recognition by the Smad anchor for receptor activation
    • COI: 1:CAS:528:DC%2BD3cXis1akuw%3D%3D, PID: 10615055
    • Wu G, Chen YG, Ozdamar B, Gyuricza CA, Chong PA, et al. Structural basis of Smad2 recognition by the Smad anchor for receptor activation. Science. 2000;287:92–7.
    • (2000) Science , vol.287 , pp. 92-97
    • Wu, G.1    Chen, Y.G.2    Ozdamar, B.3    Gyuricza, C.A.4    Chong, P.A.5
  • 16
    • 0034678908 scopus 로고    scopus 로고
    • Transcriptional control by the TGF-beta/Smad signaling system
    • COI: 1:CAS:528:DC%2BD3cXivVKlsbo%3D, PID: 10775259
    • Massague J, Wotton D. Transcriptional control by the TGF-beta/Smad signaling system. EMBO J. 2000;19:1745–54.
    • (2000) EMBO J , vol.19 , pp. 1745-1754
    • Massague, J.1    Wotton, D.2
  • 17
    • 0030837455 scopus 로고    scopus 로고
    • A structural basis for mutational inactivation of the tumour suppressor Smad4
    • COI: 1:CAS:528:DyaK2sXksVSrt78%3D, PID: 9214508
    • Shi Y, Hata A, Lo RS, Massague J, Pavletich NP. A structural basis for mutational inactivation of the tumour suppressor Smad4. Nature. 1997;388:87–93.
    • (1997) Nature , vol.388 , pp. 87-93
    • Shi, Y.1    Hata, A.2    Lo, R.S.3    Massague, J.4    Pavletich, N.P.5
  • 18
    • 0034252221 scopus 로고    scopus 로고
    • Regulation of intracellular dynamics of Smad4 by its leucine-rich nuclear export signal
    • COI: 1:CAS:528:DC%2BD3cXnt1yrsLY%3D, PID: 11265759
    • Watanabe M, Masuyama N, Fukuda M, Nishida E. Regulation of intracellular dynamics of Smad4 by its leucine-rich nuclear export signal. EMBO Rep. 2000;1:176–82.
    • (2000) EMBO Rep , vol.1 , pp. 176-182
    • Watanabe, M.1    Masuyama, N.2    Fukuda, M.3    Nishida, E.4
  • 19
    • 0035167095 scopus 로고    scopus 로고
    • Transforming growth factor-beta induces nuclear import of Smad3 in an importin-beta1 and Ran-dependent manner
    • COI: 1:CAS:528:DC%2BD3MXjtVaqsbc%3D, PID: 11294908
    • Kurisaki A, Kose S, Yoneda Y, Heldin CH, Moustakas A. Transforming growth factor-beta induces nuclear import of Smad3 in an importin-beta1 and Ran-dependent manner. Mol Biol Cell. 2001;12:1079–91.
    • (2001) Mol Biol Cell , vol.12 , pp. 1079-1091
    • Kurisaki, A.1    Kose, S.2    Yoneda, Y.3    Heldin, C.H.4    Moustakas, A.5
  • 20
    • 0034460336 scopus 로고    scopus 로고
    • Transforming growth factor beta-independent shuttling of Smad4 between the cytoplasm and nucleus
    • COI: 1:CAS:528:DC%2BD3MXitFGrsL0%3D, PID: 11074002
    • Pierreux CE, Nicolas FJ, Hill CS. Transforming growth factor beta-independent shuttling of Smad4 between the cytoplasm and nucleus. Mol Cell Biol. 2000;20:9041–54.
    • (2000) Mol Cell Biol , vol.20 , pp. 9041-9054
    • Pierreux, C.E.1    Nicolas, F.J.2    Hill, C.S.3
  • 21
    • 0036670339 scopus 로고    scopus 로고
    • Nucleocytoplasmic shuttling of Smads 2, 3, and 4 permits sensing of TGF-beta receptor activity
    • COI: 1:CAS:528:DC%2BD38Xmslyrtbg%3D, PID: 12191474
    • Inman GJ, Nicolas FJ, Hill CS. Nucleocytoplasmic shuttling of Smads 2, 3, and 4 permits sensing of TGF-beta receptor activity. Mol Cell. 2002;10:283–94.
    • (2002) Mol Cell , vol.10 , pp. 283-294
    • Inman, G.J.1    Nicolas, F.J.2    Hill, C.S.3
  • 22
    • 0038682002 scopus 로고    scopus 로고
    • Mechanisms of TGF-beta signaling from cell membrane to the nucleus
    • COI: 1:CAS:528:DC%2BD3sXkvVekt7o%3D, PID: 12809600
    • Shi Y, Massague J. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell. 2003;113:685–700.
    • (2003) Cell , vol.113 , pp. 685-700
    • Shi, Y.1    Massague, J.2
  • 23
    • 0035902115 scopus 로고    scopus 로고
    • Proliferation, cell cycle and apoptosis in cancer
    • COI: 1:CAS:528:DC%2BD3MXktVSjsr8%3D, PID: 11357141
    • Evan GI, Vousden KH. Proliferation, cell cycle and apoptosis in cancer. Nature. 2001;411:342–8.
    • (2001) Nature , vol.411 , pp. 342-348
    • Evan, G.I.1    Vousden, K.H.2
  • 24
    • 62449215107 scopus 로고    scopus 로고
    • TGFbeta prevents proteasomal degradation of the cyclin-dependent kinase inhibitor p27kip1 for cell cycle arrest
    • COI: 1:CAS:528:DC%2BD1MXlvFWju7g%3D, PID: 19221482
    • Lecanda J, Ganapathy V, D′Aquino-Ardalan C, Evans B, Cadacio C, et al. TGFbeta prevents proteasomal degradation of the cyclin-dependent kinase inhibitor p27kip1 for cell cycle arrest. Cell Cycle. 2009;8:742–56.
    • (2009) Cell Cycle , vol.8 , pp. 742-756
    • Lecanda, J.1    Ganapathy, V.2    D′Aquino-Ardalan, C.3    Evans, B.4    Cadacio, C.5
  • 25
    • 0034644472 scopus 로고    scopus 로고
    • TGFbeta signaling in growth control, cancer, and heritable disorders
    • COI: 1:CAS:528:DC%2BD3cXns1Clt7w%3D, PID: 11057902
    • Massague J, Blain SW, Lo RS. TGFbeta signaling in growth control, cancer, and heritable disorders. Cell. 2000;103:295–309.
    • (2000) Cell , vol.103 , pp. 295-309
    • Massague, J.1    Blain, S.W.2    Lo, R.S.3
  • 26
    • 84862742711 scopus 로고    scopus 로고
    • Effects of activin and TGFbeta on p21 in colon cancer
    • COI: 1:CAS:528:DC%2BC38XpsFyltrk%3D, PID: 22761777
    • Bauer J, Sporn JC, Cabral J, Gomez J, Jung B. Effects of activin and TGFbeta on p21 in colon cancer. PLoS One. 2012;7:e39381.
    • (2012) PLoS One , vol.7 , pp. e39381
    • Bauer, J.1    Sporn, J.C.2    Cabral, J.3    Gomez, J.4    Jung, B.5
  • 27
    • 0033085185 scopus 로고    scopus 로고
    • Role of transforming growth factor-beta in growth and injury response of the pancreatic duct epithelium in vitro
    • COI: 1:STN:280:DyaK1MzovVWquw%3D%3D, PID: 10457343
    • Alvarez C, Bass BL. Role of transforming growth factor-beta in growth and injury response of the pancreatic duct epithelium in vitro. J Gastrointest Surg. 1999;3:178–84.
    • (1999) J Gastrointest Surg , vol.3 , pp. 178-184
    • Alvarez, C.1    Bass, B.L.2
  • 28
    • 0030610532 scopus 로고    scopus 로고
    • Overexpression of the TGFbeta-regulated zinc finger encoding gene, TIEG, induces apoptosis in pancreatic epithelial cells
    • COI: 1:CAS:528:DyaK2sXjsVGqsbY%3D, PID: 9153278
    • Tachibana I, Imoto M, Adjei PN, Gores GJ, Subramaniam M, et al. Overexpression of the TGFbeta-regulated zinc finger encoding gene, TIEG, induces apoptosis in pancreatic epithelial cells. J Clin Invest. 1997;99:2365–74.
    • (1997) J Clin Invest , vol.99 , pp. 2365-2374
    • Tachibana, I.1    Imoto, M.2    Adjei, P.N.3    Gores, G.J.4    Subramaniam, M.5
  • 29
    • 33751311939 scopus 로고    scopus 로고
    • Inhibition of transforming growth factor-beta signaling in human cancer: targeting a tumor suppressor network as a therapeutic strategy
    • COI: 1:CAS:528:DC%2BD28XntFSmsrY%3D, PID: 16857784
    • Biswas S, Criswell TL, Wang SE, Arteaga CL. Inhibition of transforming growth factor-beta signaling in human cancer: targeting a tumor suppressor network as a therapeutic strategy. Clin Cancer Res. 2006;12:4142–6.
    • (2006) Clin Cancer Res , vol.12 , pp. 4142-4146
    • Biswas, S.1    Criswell, T.L.2    Wang, S.E.3    Arteaga, C.L.4
  • 30
    • 33845524970 scopus 로고    scopus 로고
    • Transforming growth factor-beta in cancer and metastasis
    • COI: 1:CAS:528:DC%2BD28Xht1yktb3N, PID: 16951986
    • Jakowlew SB. Transforming growth factor-beta in cancer and metastasis. Cancer Metastasis Rev. 2006;25:435–57.
    • (2006) Cancer Metastasis Rev , vol.25 , pp. 435-457
    • Jakowlew, S.B.1
  • 31
    • 0031694080 scopus 로고    scopus 로고
    • Transfection of the type I TGF-beta receptor restores TGF-beta responsiveness in pancreatic cancer
    • COI: 1:CAS:528:DyaK1cXmsValt74%3D, PID: 9754660
    • Wagner M, Kleeff J, Lopez ME, Bockman I, Massaque J, et al. Transfection of the type I TGF-beta receptor restores TGF-beta responsiveness in pancreatic cancer. Int J Cancer. 1998;78:255–60.
    • (1998) Int J Cancer , vol.78 , pp. 255-260
    • Wagner, M.1    Kleeff, J.2    Lopez, M.E.3    Bockman, I.4    Massaque, J.5
  • 32
    • 32944459015 scopus 로고    scopus 로고
    • Molecular mechanisms of pancreatic carcinogenesis
    • COI: 1:CAS:528:DC%2BD28Xht1Kqsbs%3D, PID: 16367914
    • Furukawa T, Sunamura M, Horii A. Molecular mechanisms of pancreatic carcinogenesis. Cancer Sci. 2006;97:1–7.
    • (2006) Cancer Sci , vol.97 , pp. 1-7
    • Furukawa, T.1    Sunamura, M.2    Horii, A.3
  • 33
    • 0034712832 scopus 로고    scopus 로고
    • Mutations in the tumor suppressors Smad2 and Smad4 inactivate transforming growth factor beta signaling by targeting Smads to the ubiquitin-proteasome pathway
    • COI: 1:CAS:528:DC%2BD3cXivFKjuro%3D, PID: 10781087
    • Xu J, Attisano L. Mutations in the tumor suppressors Smad2 and Smad4 inactivate transforming growth factor beta signaling by targeting Smads to the ubiquitin-proteasome pathway. Proc Natl Acad Sci U S A. 2000;97:4820–5.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 4820-4825
    • Xu, J.1    Attisano, L.2
  • 34
    • 0242490137 scopus 로고    scopus 로고
    • Restoration of SMAD4 by gene therapy reverses the invasive phenotype in pancreatic adenocarcinoma cells
    • COI: 1:CAS:528:DC%2BD3sXnvFSgsb0%3D, PID: 14534532
    • Duda DG, Sunamura M, Lefter LP, Furukawa T, Yokoyama T, et al. Restoration of SMAD4 by gene therapy reverses the invasive phenotype in pancreatic adenocarcinoma cells. Oncogene. 2003;22:6857–64.
    • (2003) Oncogene , vol.22 , pp. 6857-6864
    • Duda, D.G.1    Sunamura, M.2    Lefter, L.P.3    Furukawa, T.4    Yokoyama, T.5
  • 35
    • 28644443682 scopus 로고    scopus 로고
    • Restoration of Smad4 in BxPC3 pancreatic cancer cells attenuates proliferation without altering angiogenesis
    • COI: 1:CAS:528:DC%2BD28XhsVaqsLg%3D, PID: 16320109
    • Yasutome M, Gunn J, Korc M. Restoration of Smad4 in BxPC3 pancreatic cancer cells attenuates proliferation without altering angiogenesis. Clin Exp Metastasis. 2005;22:461–73.
    • (2005) Clin Exp Metastasis , vol.22 , pp. 461-473
    • Yasutome, M.1    Gunn, J.2    Korc, M.3
  • 36
    • 63449089228 scopus 로고    scopus 로고
    • Inhibition of pancreatic carcinoma cell growth in vitro by DPC4 gene transfection
    • COI: 1:CAS:528:DC%2BD1MXivVWns7c%3D, PID: 18985820
    • Shen W, Tao GQ, Li DC, Zhu XG, Bai X, et al. Inhibition of pancreatic carcinoma cell growth in vitro by DPC4 gene transfection. World J Gastroenterol. 2008;14:6254–60.
    • (2008) World J Gastroenterol , vol.14 , pp. 6254-6260
    • Shen, W.1    Tao, G.Q.2    Li, D.C.3    Zhu, X.G.4    Bai, X.5
  • 37
    • 0022373618 scopus 로고
    • Human transforming growth factor-beta complementary DNA sequence and expression in normal and transformed cells
    • COI: 1:CAS:528:DyaL2MXlsFGit7s%3D, PID: 3861940
    • Derynck R, Jarrett JA, Chen EY, Eaton DH, Bell JR, et al. Human transforming growth factor-beta complementary DNA sequence and expression in normal and transformed cells. Nature. 1985;316:701–5.
    • (1985) Nature , vol.316 , pp. 701-705
    • Derynck, R.1    Jarrett, J.A.2    Chen, E.Y.3    Eaton, D.H.4    Bell, J.R.5
  • 38
    • 24344483878 scopus 로고    scopus 로고
    • Smad4 dependency defines two classes of transforming growth factor {beta} (TGF-{beta}) target genes and distinguishes TGF-{beta}-induced epithelial-mesenchymal transition from its antiproliferative and migratory responses
    • COI: 1:CAS:528:DC%2BD2MXhtVWisL3N, PID: 16135802
    • Levy L, Hill CS. Smad4 dependency defines two classes of transforming growth factor {beta} (TGF-{beta}) target genes and distinguishes TGF-{beta}-induced epithelial-mesenchymal transition from its antiproliferative and migratory responses. Mol Cell Biol. 2005;25:8108–25.
    • (2005) Mol Cell Biol , vol.25 , pp. 8108-8125
    • Levy, L.1    Hill, C.S.2
  • 39
    • 24944497786 scopus 로고    scopus 로고
    • Non-Smad TGF-beta signals
    • COI: 1:CAS:528:DC%2BD2MXhtVaktrvK, PID: 16105881
    • Moustakas A, Heldin CH. Non-Smad TGF-beta signals. J Cell Sci. 2005;118:3573–84.
    • (2005) J Cell Sci , vol.118 , pp. 3573-3584
    • Moustakas, A.1    Heldin, C.H.2
  • 40
    • 36148968456 scopus 로고    scopus 로고
    • RAS/ERK modulates TGFbeta-regulated PTEN expression in human pancreatic adenocarcinoma cells
    • COI: 1:CAS:528:DC%2BD2sXht1yktbbL, PID: 17638924
    • Chow JY, Quach KT, Cabrera BL, Cabral JA, Beck SE, et al. RAS/ERK modulates TGFbeta-regulated PTEN expression in human pancreatic adenocarcinoma cells. Carcinogenesis. 2007;28:2321–7.
    • (2007) Carcinogenesis , vol.28 , pp. 2321-2327
    • Chow, J.Y.1    Quach, K.T.2    Cabrera, B.L.3    Cabral, J.A.4    Beck, S.E.5
  • 41
    • 76749088993 scopus 로고    scopus 로고
    • TGF-beta downregulates PTEN via activation of NF-kappaB in pancreatic cancer cells
    • COI: 1:CAS:528:DC%2BC3cXhvVyrsLg%3D, PID: 19940030
    • Chow JY, Ban M, Wu HL, Nguyen F, Huang M, et al. TGF-beta downregulates PTEN via activation of NF-kappaB in pancreatic cancer cells. Am J Physiol Gastrointest Liver Physiol. 2010;298:G275–82.
    • (2010) Am J Physiol Gastrointest Liver Physiol , vol.298 , pp. G275-G282
    • Chow, J.Y.1    Ban, M.2    Wu, H.L.3    Nguyen, F.4    Huang, M.5
  • 42
    • 80053451803 scopus 로고    scopus 로고
    • STAT3 knockdown reduces pancreatic cancer cell invasiveness and matrix metalloproteinase-7 expression in nude mice
    • COI: 1:CAS:528:DC%2BC3MXhtlGqsb7N, PID: 21991388
    • Li H, Huang C, Huang K, Wu W, Jiang T, et al. STAT3 knockdown reduces pancreatic cancer cell invasiveness and matrix metalloproteinase-7 expression in nude mice. PLoS One. 2011;6:e25941.
    • (2011) PLoS One , vol.6 , pp. e25941
    • Li, H.1    Huang, C.2    Huang, K.3    Wu, W.4    Jiang, T.5
  • 43
    • 70350463717 scopus 로고    scopus 로고
    • Lentivirus-mediated shRNA interference targeting STAT3 inhibits human pancreatic cancer cell invasion
    • COI: 1:CAS:528:DC%2BD1MXhtVemtLbI, PID: 19673016
    • Yang G, Huang C, Cao J, Huang KJ, Jiang T, et al. Lentivirus-mediated shRNA interference targeting STAT3 inhibits human pancreatic cancer cell invasion. World J Gastroenterol. 2009;15:3757–66.
    • (2009) World J Gastroenterol , vol.15 , pp. 3757-3766
    • Yang, G.1    Huang, C.2    Cao, J.3    Huang, K.J.4    Jiang, T.5
  • 44
    • 79955823538 scopus 로고    scopus 로고
    • STAT3-targeting RNA interference inhibits pancreatic cancer angiogenesis in vitro and in vivo
    • COI: 1:CAS:528:DC%2BC3MXns1Kitr8%3D, PID: 21479358
    • Huang C, Jiang T, Zhu L, Liu J, Cao J, et al. STAT3-targeting RNA interference inhibits pancreatic cancer angiogenesis in vitro and in vivo. Int J Oncol. 2011;38:1637–44.
    • (2011) Int J Oncol , vol.38 , pp. 1637-1644
    • Huang, C.1    Jiang, T.2    Zhu, L.3    Liu, J.4    Cao, J.5
  • 45
    • 49249095430 scopus 로고    scopus 로고
    • Inhibition of STAT3 Tyr705 phosphorylation by Smad4 suppresses transforming growth factor beta-mediated invasion and metastasis in pancreatic cancer cells
    • COI: 1:CAS:528:DC%2BD1cXmsFKmtbo%3D, PID: 18519681
    • Zhao S, Venkatasubbarao K, Lazor JW, Sperry J, Jin C, et al. Inhibition of STAT3 Tyr705 phosphorylation by Smad4 suppresses transforming growth factor beta-mediated invasion and metastasis in pancreatic cancer cells. Cancer Res. 2008;68:4221–8.
    • (2008) Cancer Res , vol.68 , pp. 4221-4228
    • Zhao, S.1    Venkatasubbarao, K.2    Lazor, J.W.3    Sperry, J.4    Jin, C.5
  • 46
    • 45549104746 scopus 로고    scopus 로고
    • Smad4-dependent TGF-beta signaling suppresses RON receptor tyrosine kinase-dependent motility and invasion of pancreatic cancer cells
    • COI: 1:CAS:528:DC%2BD1cXkvVSgsbs%3D, PID: 18310076
    • Zhao S, Ammanamanchi S, Brattain M, Cao L, Thangasamy A, et al. Smad4-dependent TGF-beta signaling suppresses RON receptor tyrosine kinase-dependent motility and invasion of pancreatic cancer cells. J Biol Chem. 2008;283:11293–301.
    • (2008) J Biol Chem , vol.283 , pp. 11293-11301
    • Zhao, S.1    Ammanamanchi, S.2    Brattain, M.3    Cao, L.4    Thangasamy, A.5
  • 47
    • 68249108045 scopus 로고    scopus 로고
    • Inactivation of TIF1gamma cooperates with Kras to induce cystic tumors of the pancreas
    • PID: 19629168
    • Vincent DF, Yan KP, Treilleux I, Gay F, Arfi V, et al. Inactivation of TIF1gamma cooperates with Kras to induce cystic tumors of the pancreas. PLoS Genet. 2009;5:e1000575.
    • (2009) PLoS Genet , vol.5 , pp. e1000575
    • Vincent, D.F.1    Yan, K.P.2    Treilleux, I.3    Gay, F.4    Arfi, V.5
  • 48
    • 84925510415 scopus 로고    scopus 로고
    • Imbalanced expression of Tif1gamma inhibits pancreatic ductal epithelial cell growth
    • PID: 24959375
    • Ligr M, Wu X, Daniels G, Zhang D, Wang H, et al. Imbalanced expression of Tif1gamma inhibits pancreatic ductal epithelial cell growth. Am J Cancer Res. 2014;4:196–210.
    • (2014) Am J Cancer Res , vol.4 , pp. 196-210
    • Ligr, M.1    Wu, X.2    Daniels, G.3    Zhang, D.4    Wang, H.5
  • 49
    • 84861610442 scopus 로고    scopus 로고
    • Tif1gamma suppresses murine pancreatic tumoral transformation by a Smad4-independent pathway
    • COI: 1:CAS:528:DC%2BC38XhtVyntrbO, PID: 22469842
    • Vincent DF, Gout J, Chuvin N, Arfi V, Pommier RM, et al. Tif1gamma suppresses murine pancreatic tumoral transformation by a Smad4-independent pathway. Am J Pathol. 2012;180:2214–21.
    • (2012) Am J Pathol , vol.180 , pp. 2214-2221
    • Vincent, D.F.1    Gout, J.2    Chuvin, N.3    Arfi, V.4    Pommier, R.M.5
  • 50
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • COI: 1:CAS:528:DC%2BC3cXksFWltA%3D%3D, PID: 19945376
    • Thiery JP, Acloque H, Huang RY, Nieto MA. Epithelial-mesenchymal transitions in development and disease. Cell. 2009;139:871–90.
    • (2009) Cell , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3    Nieto, M.A.4
  • 51
    • 63049123066 scopus 로고    scopus 로고
    • Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits
    • COI: 1:CAS:528:DC%2BD1MXis1Chtb0%3D, PID: 19262571
    • Polyak K, Weinberg RA. Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nat Rev Cancer. 2009;9:265–73.
    • (2009) Nat Rev Cancer , vol.9 , pp. 265-273
    • Polyak, K.1    Weinberg, R.A.2
  • 52
    • 84857052013 scopus 로고    scopus 로고
    • Contribution of epithelial-to-mesenchymal transition and cancer stem cells to pancreatic cancer progression
    • PID: 22099597
    • Krantz SB, Shields MA, Dangi-Garimella S, Munshi HG, Bentrem DJ. Contribution of epithelial-to-mesenchymal transition and cancer stem cells to pancreatic cancer progression. J Surg Res. 2012;173:105–12.
    • (2012) J Surg Res , vol.173 , pp. 105-112
    • Krantz, S.B.1    Shields, M.A.2    Dangi-Garimella, S.3    Munshi, H.G.4    Bentrem, D.J.5
  • 53
    • 77952896646 scopus 로고    scopus 로고
    • TGFbeta signalling: a complex web in cancer progression
    • COI: 1:CAS:528:DC%2BC3cXmsVWntLc%3D, PID: 20495575
    • Ikushima H, Miyazono K. TGFbeta signalling: a complex web in cancer progression. Nat Rev Cancer. 2010;10:415–24.
    • (2010) Nat Rev Cancer , vol.10 , pp. 415-424
    • Ikushima, H.1    Miyazono, K.2
  • 54
    • 34547587877 scopus 로고    scopus 로고
    • Cell size and invasion in TGF-beta-induced epithelial to mesenchymal transition is regulated by activation of the mTOR pathway
    • COI: 1:CAS:528:DC%2BD2sXos1CrsLw%3D, PID: 17646396
    • Lamouille S, Derynck R. Cell size and invasion in TGF-beta-induced epithelial to mesenchymal transition is regulated by activation of the mTOR pathway. J Cell Biol. 2007;178:437–51.
    • (2007) J Cell Biol , vol.178 , pp. 437-451
    • Lamouille, S.1    Derynck, R.2
  • 55
    • 84861448736 scopus 로고    scopus 로고
    • TGF-beta-induced activation of mTOR complex 2 drives epithelial-mesenchymal transition and cell invasion
    • COI: 1:CAS:528:DC%2BC38XnsVWjsbc%3D, PID: 22399812
    • Lamouille S, Connolly E, Smyth JW, Akhurst RJ, Derynck R. TGF-beta-induced activation of mTOR complex 2 drives epithelial-mesenchymal transition and cell invasion. J Cell Sci. 2012;125:1259–73.
    • (2012) J Cell Sci , vol.125 , pp. 1259-1273
    • Lamouille, S.1    Connolly, E.2    Smyth, J.W.3    Akhurst, R.J.4    Derynck, R.5
  • 56
    • 33751251034 scopus 로고    scopus 로고
    • Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer
    • COI: 1:CAS:528:DC%2BD28Xht1Gnt7%2FO, PID: 17114584
    • Bardeesy N, Cheng KH, Berger JH, Chu GC, Pahler J, et al. Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer. Genes Dev. 2006;20:3130–46.
    • (2006) Genes Dev , vol.20 , pp. 3130-3146
    • Bardeesy, N.1    Cheng, K.H.2    Berger, J.H.3    Chu, G.C.4    Pahler, J.5
  • 57
    • 68249092353 scopus 로고    scopus 로고
    • A SNAIL1-SMAD3/4 transcriptional repressor complex promotes TGF-beta mediated epithelial-mesenchymal transition
    • COI: 1:CAS:528:DC%2BD1MXpsVaktbk%3D, PID: 19597490
    • Vincent T, Neve EP, Johnson JR, Kukalev A, Rojo F, et al. A SNAIL1-SMAD3/4 transcriptional repressor complex promotes TGF-beta mediated epithelial-mesenchymal transition. Nat Cell Biol. 2009;11:943–50.
    • (2009) Nat Cell Biol , vol.11 , pp. 943-950
    • Vincent, T.1    Neve, E.P.2    Johnson, J.R.3    Kukalev, A.4    Rojo, F.5
  • 58
    • 54049084380 scopus 로고    scopus 로고
    • A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition
    • COI: 1:CAS:528:DC%2BD1cXhtF2msLzK, PID: 18829540
    • Bracken CP, Gregory PA, Kolesnikoff N, Bert AG, Wang J, et al. A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition. Cancer Res. 2008;68:7846–54.
    • (2008) Cancer Res , vol.68 , pp. 7846-7854
    • Bracken, C.P.1    Gregory, P.A.2    Kolesnikoff, N.3    Bert, A.G.4    Wang, J.5
  • 59
    • 84871948755 scopus 로고    scopus 로고
    • TGF-beta signaling and epithelial-mesenchymal transition in cancer progression
    • COI: 1:CAS:528:DC%2BC38XhvVSisrrM, PID: 23197193
    • Katsuno Y, Lamouille S, Derynck R. TGF-beta signaling and epithelial-mesenchymal transition in cancer progression. Curr Opin Oncol. 2013;25:76–84.
    • (2013) Curr Opin Oncol , vol.25 , pp. 76-84
    • Katsuno, Y.1    Lamouille, S.2    Derynck, R.3
  • 60
    • 77951710240 scopus 로고    scopus 로고
    • Phenotype and genotype of pancreatic cancer cell lines
    • COI: 1:CAS:528:DC%2BC3cXnsVOkt7k%3D, PID: 20418756
    • Deer EL, Gonzalez-Hernandez J, Coursen JD, Shea JE, Ngatia J, et al. Phenotype and genotype of pancreatic cancer cell lines. Pancreas. 2010;39:425–35.
    • (2010) Pancreas , vol.39 , pp. 425-435
    • Deer, E.L.1    Gonzalez-Hernandez, J.2    Coursen, J.D.3    Shea, J.E.4    Ngatia, J.5
  • 61
    • 4644266467 scopus 로고    scopus 로고
    • Orthotopic transplantation models of pancreatic adenocarcinoma derived from cell lines and primary tumors and displaying varying metastatic activity
    • COI: 1:CAS:528:DC%2BD2cXptFSjsL0%3D, PID: 15367885
    • Loukopoulos P, Kanetaka K, Takamura M, Shibata T, Sakamoto M, et al. Orthotopic transplantation models of pancreatic adenocarcinoma derived from cell lines and primary tumors and displaying varying metastatic activity. Pancreas. 2004;29:193–203.
    • (2004) Pancreas , vol.29 , pp. 193-203
    • Loukopoulos, P.1    Kanetaka, K.2    Takamura, M.3    Shibata, T.4    Sakamoto, M.5
  • 62
    • 0035234009 scopus 로고    scopus 로고
    • Characterization of the mutations of the K-ras, p53, p16, and SMAD4 genes in 15 human pancreatic cancer cell lines
    • COI: 1:CAS:528:DC%2BD3MXjsFakuw%3D%3D, PID: 11115575
    • Sun C, Yamato T, Furukawa T, Ohnishi Y, Kijima H, et al. Characterization of the mutations of the K-ras, p53, p16, and SMAD4 genes in 15 human pancreatic cancer cell lines. Oncol Rep. 2001;8:89–92.
    • (2001) Oncol Rep , vol.8 , pp. 89-92
    • Sun, C.1    Yamato, T.2    Furukawa, T.3    Ohnishi, Y.4    Kijima, H.5
  • 63
    • 0033853892 scopus 로고    scopus 로고
    • Reassessment of K-ras mutations at codon 12 by direct PCR and sequencing from tissue microdissection in human pancreatic adenocarcinomas
    • COI: 1:STN:280:DC%2BD3M%2Fmtl2lug%3D%3D, PID: 10975709
    • Aoki Y, Hosaka S, Tachibana N, Karasawa Y, Kawa S, et al. Reassessment of K-ras mutations at codon 12 by direct PCR and sequencing from tissue microdissection in human pancreatic adenocarcinomas. Pancreas. 2000;21:152–7.
    • (2000) Pancreas , vol.21 , pp. 152-157
    • Aoki, Y.1    Hosaka, S.2    Tachibana, N.3    Karasawa, Y.4    Kawa, S.5
  • 64
    • 0037183984 scopus 로고    scopus 로고
    • Smad4/DPC4-dependent regulation of biglycan gene expression by transforming growth factor-beta in pancreatic tumor cells
    • COI: 1:CAS:528:DC%2BD38XnsVCjsLc%3D, PID: 12140283
    • Chen WB, Lenschow W, Tiede K, Fischer JW, Kalthoff H, et al. Smad4/DPC4-dependent regulation of biglycan gene expression by transforming growth factor-beta in pancreatic tumor cells. J Biol Chem. 2002;277:36118–28.
    • (2002) J Biol Chem , vol.277 , pp. 36118-36128
    • Chen, W.B.1    Lenschow, W.2    Tiede, K.3    Fischer, J.W.4    Kalthoff, H.5
  • 66
    • 0035207991 scopus 로고    scopus 로고
    • Genetic profile of 22 pancreatic carcinoma cell lines. Analysis of K-ras, p53, p16 and DPC4/Smad4
    • COI: 1:CAS:528:DC%2BD3MXoslSmtbY%3D, PID: 11787853
    • Moore PS, Sipos B, Orlandini S, Sorio C, Real FX, et al. Genetic profile of 22 pancreatic carcinoma cell lines. Analysis of K-ras, p53, p16 and DPC4/Smad4. Virchows Arch. 2001;439:798–802.
    • (2001) Virchows Arch , vol.439 , pp. 798-802
    • Moore, P.S.1    Sipos, B.2    Orlandini, S.3    Sorio, C.4    Real, F.X.5
  • 67
    • 0141742113 scopus 로고    scopus 로고
    • Multicomponent analysis of the pancreatic adenocarcinoma progression model using a pancreatic intraepithelial neoplasia tissue microarray
    • PID: 13679454
    • Maitra A, Adsay NV, Argani P, Iacobuzio-Donahue C, De Marzo A, et al. Multicomponent analysis of the pancreatic adenocarcinoma progression model using a pancreatic intraepithelial neoplasia tissue microarray. Mod Pathol. 2003;16:902–12.
    • (2003) Mod Pathol , vol.16 , pp. 902-912
    • Maitra, A.1    Adsay, N.V.2    Argani, P.3    Iacobuzio-Donahue, C.4    De Marzo, A.5
  • 68
    • 0035020633 scopus 로고    scopus 로고
    • Pancreatic intraepithelial neoplasia: a new nomenclature and classification system for pancreatic duct lesions
    • COI: 1:STN:280:DC%2BD3M3ktV2kuw%3D%3D, PID: 11342768
    • Hruban RH, Adsay NV, Albores-Saavedra J, Compton C, Garrett ES, et al. Pancreatic intraepithelial neoplasia: a new nomenclature and classification system for pancreatic duct lesions. Am J Surg Pathol. 2001;25:579–86.
    • (2001) Am J Surg Pathol , vol.25 , pp. 579-586
    • Hruban, R.H.1    Adsay, N.V.2    Albores-Saavedra, J.3    Compton, C.4    Garrett, E.S.5
  • 69
    • 3042570232 scopus 로고    scopus 로고
    • The pathology of ductal-type pancreatic carcinomas and pancreatic intraepithelial neoplasia: insights for clinicians
    • PID: 15191688
    • Kloppel G, Luttges J. The pathology of ductal-type pancreatic carcinomas and pancreatic intraepithelial neoplasia: insights for clinicians. Curr Gastroenterol Rep. 2004;6:111–8.
    • (2004) Curr Gastroenterol Rep , vol.6 , pp. 111-118
    • Kloppel, G.1    Luttges, J.2
  • 70
    • 27644510498 scopus 로고    scopus 로고
    • Histopathological diagnosis of pancreatic intraepithelial neoplasia and intraductal papillary-mucinous neoplasms: interobserver agreement
    • PID: 16258368
    • Longnecker DS, Adsay NV, Fernandez-del Castillo C, Hruban RH, Kasugai T, et al. Histopathological diagnosis of pancreatic intraepithelial neoplasia and intraductal papillary-mucinous neoplasms: interobserver agreement. Pancreas. 2005;31:344–9.
    • (2005) Pancreas , vol.31 , pp. 344-349
    • Longnecker, D.S.1    Adsay, N.V.2    Fernandez-del Castillo, C.3    Hruban, R.H.4    Kasugai, T.5
  • 71
    • 0034032009 scopus 로고    scopus 로고
    • Loss of expression of Dpc4 in pancreatic intraepithelial neoplasia: evidence that DPC4 inactivation occurs late in neoplastic progression
    • COI: 1:CAS:528:DC%2BD3cXisVymsr0%3D, PID: 10766191
    • Wilentz RE, Iacobuzio-Donahue CA, Argani P, McCarthy DM, Parsons JL, et al. Loss of expression of Dpc4 in pancreatic intraepithelial neoplasia: evidence that DPC4 inactivation occurs late in neoplastic progression. Cancer Res. 2000;60:2002–6.
    • (2000) Cancer Res , vol.60 , pp. 2002-2006
    • Wilentz, R.E.1    Iacobuzio-Donahue, C.A.2    Argani, P.3    McCarthy, D.M.4    Parsons, J.L.5
  • 72
    • 0036110390 scopus 로고    scopus 로고
    • Aberrant p16(INK4A) and DPC4/Smad4 expression in intraductal papillary mucinous tumours of the pancreas is associated with invasive ductal adenocarcinoma
    • COI: 1:CAS:528:DC%2BD38XkvVGktLw%3D, PID: 12010891
    • Biankin AV, Biankin SA, Kench JG, Morey AL, Lee CS, et al. Aberrant p16(INK4A) and DPC4/Smad4 expression in intraductal papillary mucinous tumours of the pancreas is associated with invasive ductal adenocarcinoma. Gut. 2002;50:861–8.
    • (2002) Gut , vol.50 , pp. 861-868
    • Biankin, A.V.1    Biankin, S.A.2    Kench, J.G.3    Morey, A.L.4    Lee, C.S.5
  • 73
    • 0034495006 scopus 로고    scopus 로고
    • Dpc-4 protein is expressed in virtually all human intraductal papillary mucinous neoplasms of the pancreas: comparison with conventional ductal adenocarcinomas
    • COI: 1:CAS:528:DC%2BD3cXmvFWqt74%3D, PID: 10980115
    • Iacobuzio-Donahue CA, Klimstra DS, Adsay NV, Wilentz RE, Argani P, et al. Dpc-4 protein is expressed in virtually all human intraductal papillary mucinous neoplasms of the pancreas: comparison with conventional ductal adenocarcinomas. Am J Pathol. 2000;157:755–61.
    • (2000) Am J Pathol , vol.157 , pp. 755-761
    • Iacobuzio-Donahue, C.A.1    Klimstra, D.S.2    Adsay, N.V.3    Wilentz, R.E.4    Argani, P.5
  • 74
    • 0033891752 scopus 로고    scopus 로고
    • Immunohistochemical labeling for dpc4 mirrors genetic status in pancreatic adenocarcinomas : a new marker of DPC4 inactivation
    • COI: 1:CAS:528:DC%2BD3cXns1ymtA%3D%3D, PID: 10623651
    • Wilentz RE, Su GH, Dai JL, Sparks AB, Argani P, et al. Immunohistochemical labeling for dpc4 mirrors genetic status in pancreatic adenocarcinomas: a new marker of DPC4 inactivation. Am J Pathol. 2000;156:37–43.
    • (2000) Am J Pathol , vol.156 , pp. 37-43
    • Wilentz, R.E.1    Su, G.H.2    Dai, J.L.3    Sparks, A.B.4    Argani, P.5
  • 77
    • 34248204213 scopus 로고    scopus 로고
    • Precursor lesions of pancreatic cancer: molecular pathology and clinical implications
    • COI: 1:CAS:528:DC%2BD1cXitVKjsb8%3D, PID: 17449961
    • Singh M, Maitra A. Precursor lesions of pancreatic cancer: molecular pathology and clinical implications. Pancreatology. 2007;7:9–19.
    • (2007) Pancreatology , vol.7 , pp. 9-19
    • Singh, M.1    Maitra, A.2
  • 78
  • 79
    • 33751247898 scopus 로고    scopus 로고
    • Aggressive pancreatic ductal adenocarcinoma in mice caused by pancreas-specific blockade of transforming growth factor-beta signaling in cooperation with active Kras expression
    • COI: 1:CAS:528:DC%2BD28Xht1Gnt7%2FP, PID: 17114585
    • Ijichi H, Chytil A, Gorska AE, Aakre ME, Fujitani Y, et al. Aggressive pancreatic ductal adenocarcinoma in mice caused by pancreas-specific blockade of transforming growth factor-beta signaling in cooperation with active Kras expression. Genes Dev. 2006;20:3147–60.
    • (2006) Genes Dev , vol.20 , pp. 3147-3160
    • Ijichi, H.1    Chytil, A.2    Gorska, A.E.3    Aakre, M.E.4    Fujitani, Y.5
  • 80
    • 33847387472 scopus 로고    scopus 로고
    • Kras(G12D) and Smad4/Dpc4 haploinsufficiency cooperate to induce mucinous cystic neoplasms and invasive adenocarcinoma of the pancreas
    • COI: 1:CAS:528:DC%2BD2sXjsVymtL8%3D, PID: 17349581
    • Izeradjene K, Combs C, Best M, Gopinathan A, Wagner A, et al. Kras(G12D) and Smad4/Dpc4 haploinsufficiency cooperate to induce mucinous cystic neoplasms and invasive adenocarcinoma of the pancreas. Cancer Cell. 2007;11:229–43.
    • (2007) Cancer Cell , vol.11 , pp. 229-243
    • Izeradjene, K.1    Combs, C.2    Best, M.3    Gopinathan, A.4    Wagner, A.5
  • 81
    • 84893530385 scopus 로고    scopus 로고
    • Loss of canonical Smad4 signaling promotes KRAS driven malignant transformation of human pancreatic duct epithelial cells and metastasis
    • PID: 24386371
    • Leung L, Radulovich N, Zhu CQ, Wang D, To C, et al. Loss of canonical Smad4 signaling promotes KRAS driven malignant transformation of human pancreatic duct epithelial cells and metastasis. PLoS One. 2013;8:e84366.
    • (2013) PLoS One , vol.8 , pp. e84366
    • Leung, L.1    Radulovich, N.2    Zhu, C.Q.3    Wang, D.4    To, C.5
  • 82
    • 84885186411 scopus 로고    scopus 로고
    • Reduced expression of bone morphogenetic protein receptor IA in pancreatic cancer is associated with a poor prognosis
    • COI: 1:CAS:528:DC%2BC3sXhsFynur%2FL, PID: 23969729
    • Voorneveld PW, Stache V, Jacobs RJ, Smolders E, Sitters AI, et al. Reduced expression of bone morphogenetic protein receptor IA in pancreatic cancer is associated with a poor prognosis. Br J Cancer. 2013;109:1805–12.
    • (2013) Br J Cancer , vol.109 , pp. 1805-1812
    • Voorneveld, P.W.1    Stache, V.2    Jacobs, R.J.3    Smolders, E.4    Sitters, A.I.5
  • 83
    • 2442533068 scopus 로고    scopus 로고
    • The dissociated expression of protein and messenger RNA of DPC4 in human invasive ductal carcinoma of the pancreas and their implication for patient outcome
    • PID: 15154643
    • Toga T, Nio Y, Hashimoto K, Higami T, Maruyama R. The dissociated expression of protein and messenger RNA of DPC4 in human invasive ductal carcinoma of the pancreas and their implication for patient outcome. Anticancer Res. 2004;24:1173–8.
    • (2004) Anticancer Res , vol.24 , pp. 1173-1178
    • Toga, T.1    Nio, Y.2    Hashimoto, K.3    Higami, T.4    Maruyama, R.5
  • 84
    • 0035671396 scopus 로고    scopus 로고
    • The SMAD4 protein and prognosis of pancreatic ductal adenocarcinoma
    • COI: 1:CAS:528:DC%2BD38XltFShsA%3D%3D, PID: 11751510
    • Tascilar M, Skinner HG, Rosty C, Sohn T, Wilentz RE, et al. The SMAD4 protein and prognosis of pancreatic ductal adenocarcinoma. Clin Cancer Res. 2001;7:4115–21.
    • (2001) Clin Cancer Res , vol.7 , pp. 4115-4121
    • Tascilar, M.1    Skinner, H.G.2    Rosty, C.3    Sohn, T.4    Wilentz, R.E.5
  • 85
    • 84859941196 scopus 로고    scopus 로고
    • SMAD4 genetic alterations predict a worse prognosis in patients with pancreatic ductal adenocarcinoma
    • COI: 1:CAS:528:DC%2BC38Xls12htLs%3D, PID: 22504380
    • Singh P, Srinivasan R, Wig JD. SMAD4 genetic alterations predict a worse prognosis in patients with pancreatic ductal adenocarcinoma. Pancreas. 2012;41:541–6.
    • (2012) Pancreas , vol.41 , pp. 541-546
    • Singh, P.1    Srinivasan, R.2    Wig, J.D.3
  • 86
    • 0348227997 scopus 로고    scopus 로고
    • Loss of DPC4 expression and its correlation with clinicopathological parameters in pancreatic carcinoma
    • COI: 1:CAS:528:DC%2BD2cXmt1Clug%3D%3D, PID: 14669329
    • Hua Z, Zhang YC, Hu XM, Jia ZG. Loss of DPC4 expression and its correlation with clinicopathological parameters in pancreatic carcinoma. World J Gastroenterol. 2003;9:2764–7.
    • (2003) World J Gastroenterol , vol.9 , pp. 2764-2767
    • Hua, Z.1    Zhang, Y.C.2    Hu, X.M.3    Jia, Z.G.4
  • 87
    • 24044507297 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and DPC4 predict adjuvant therapy outcomes in resected pancreatic cancer
    • PID: 16137582
    • Khorana AA, Hu YC, Ryan CK, Komorowski RA, Hostetter G, et al. Vascular endothelial growth factor and DPC4 predict adjuvant therapy outcomes in resected pancreatic cancer. J Gastrointest Surg. 2005;9:903–11.
    • (2005) J Gastrointest Surg , vol.9 , pp. 903-911
    • Khorana, A.A.1    Hu, Y.C.2    Ryan, C.K.3    Komorowski, R.A.4    Hostetter, G.5
  • 88
    • 0036894028 scopus 로고    scopus 로고
    • DPC4/Smad4 expression and outcome in pancreatic ductal adenocarcinoma
    • COI: 1:CAS:528:DC%2BD38XovVeisL4%3D, PID: 12454109
    • Biankin AV, Morey AL, Lee CS, Kench JG, Biankin SA, et al. DPC4/Smad4 expression and outcome in pancreatic ductal adenocarcinoma. J Clin Oncol. 2002;20:4531–42.
    • (2002) J Clin Oncol , vol.20 , pp. 4531-4542
    • Biankin, A.V.1    Morey, A.L.2    Lee, C.S.3    Kench, J.G.4    Biankin, S.A.5
  • 89
    • 68049115773 scopus 로고    scopus 로고
    • SMAD4 gene mutations are associated with poor prognosis in pancreatic cancer
    • COI: 1:CAS:528:DC%2BD1MXosV2ltLg%3D, PID: 19584151
    • Blackford A, Serrano OK, Wolfgang CL, Parmigiani G, Jones S, et al. SMAD4 gene mutations are associated with poor prognosis in pancreatic cancer. Clin Cancer Res. 2009;15:4674–9.
    • (2009) Clin Cancer Res , vol.15 , pp. 4674-4679
    • Blackford, A.1    Serrano, O.K.2    Wolfgang, C.L.3    Parmigiani, G.4    Jones, S.5
  • 90
    • 62249176551 scopus 로고    scopus 로고
    • DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer
    • COI: 1:CAS:528:DC%2BD1MXltlSis7o%3D, PID: 19273710
    • Iacobuzio-Donahue CA, Fu B, Yachida S, Luo M, Abe H, et al. DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer. J Clin Oncol. 2009;27:1806–13.
    • (2009) J Clin Oncol , vol.27 , pp. 1806-1813
    • Iacobuzio-Donahue, C.A.1    Fu, B.2    Yachida, S.3    Luo, M.4    Abe, H.5
  • 91
    • 0033814963 scopus 로고    scopus 로고
    • Loss of Dpc4 expression in colonic adenocarcinomas correlates with the presence of metastatic disease
    • COI: 1:CAS:528:DC%2BD3cXnsVKjtbY%3D, PID: 11021814
    • Maitra A, Molberg K, Albores-Saavedra J, Lindberg G. Loss of Dpc4 expression in colonic adenocarcinomas correlates with the presence of metastatic disease. Am J Pathol. 2000;157:1105–11.
    • (2000) Am J Pathol , vol.157 , pp. 1105-1111
    • Maitra, A.1    Molberg, K.2    Albores-Saavedra, J.3    Lindberg, G.4
  • 92
    • 0035039284 scopus 로고    scopus 로고
    • High-throughput drug screening of the DPC4 tumor-suppressor pathway in human pancreatic cancer cells
    • COI: 1:STN:280:DC%2BD3MzisFKrsg%3D%3D, PID: 11323508
    • Sohn TA, Su GH, Ryu B, Yeo CJ, Kern SE. High-throughput drug screening of the DPC4 tumor-suppressor pathway in human pancreatic cancer cells. Ann Surg. 2001;233:696–703.
    • (2001) Ann Surg , vol.233 , pp. 696-703
    • Sohn, T.A.1    Su, G.H.2    Ryu, B.3    Yeo, C.J.4    Kern, S.E.5
  • 93
    • 33750340590 scopus 로고    scopus 로고
    • Identification of an agent selectively targeting DPC4 (deleted in pancreatic cancer locus 4)-deficient pancreatic cancer cells
    • COI: 1:CAS:528:DC%2BD28XhtVams7vN, PID: 17018631
    • Wang H, Han H, Von Hoff DD. Identification of an agent selectively targeting DPC4 (deleted in pancreatic cancer locus 4)-deficient pancreatic cancer cells. Cancer Res. 2006;66:9722–30.
    • (2006) Cancer Res , vol.66 , pp. 9722-9730
    • Wang, H.1    Han, H.2    Von Hoff, D.D.3
  • 94
    • 67651100613 scopus 로고    scopus 로고
    • Identification and characterization of a novel anticancer agent with selectivity against deleted in pancreatic cancer locus 4 (DPC4)-deficient pancreatic and colon cancer cells
    • COI: 1:CAS:528:DC%2BD1MXnsFyhs70%3D, PID: 19276868
    • Wang H, Stephens B, Von Hoff DD, Han H. Identification and characterization of a novel anticancer agent with selectivity against deleted in pancreatic cancer locus 4 (DPC4)-deficient pancreatic and colon cancer cells. Pancreas. 2009;38:551–7.
    • (2009) Pancreas , vol.38 , pp. 551-557
    • Wang, H.1    Stephens, B.2    Von Hoff, D.D.3    Han, H.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.