메뉴 건너뛰기




Volumn 10, Issue SUPPL. 4, 1999, Pages

Progress in cancer genetics: Lessons from pancreatic cancer

Author keywords

ALK 5; BRCA2; DPC4; Mismatch repair; p16; Pancreas cancer; Tumor suppressor genes

Indexed keywords

PROTEIN P16; PROTEIN P53; TELOMERASE;

EID: 0032812487     PISSN: 09237534     EISSN: None     Source Type: Journal    
DOI: 10.1093/annonc/10.suppl_4.S4     Document Type: Conference Paper
Times cited : (71)

References (87)
  • 1
    • 0027270033 scopus 로고
    • Clonality: More than just a tumor-progression model
    • Kern SE. Clonality: more than just a tumor-progression model. J Natl Cancer Inst 1993;85:1020-1.
    • (1993) J Natl Cancer Inst , vol.85 , pp. 1020-1021
    • Kern, S.E.1
  • 2
    • 0002948391 scopus 로고    scopus 로고
    • The role of caretakers and gatekeepers
    • Eds; Vogelstein B, and Kinzler KW. MacGraw Hill
    • Familial Cancer Syndromes: The role of caretakers and gatekeepers. In: The Genetic Basis of Human Cancer, pgs 241-2. Eds; Vogelstein B, and Kinzler KW. 1998 MacGraw Hill.
    • (1998) The Genetic Basis of Human Cancer , pp. 241-242
  • 3
    • 3242668449 scopus 로고    scopus 로고
    • Progressive genetic abnormalities in human neoplasia
    • Eds; J Mendelsohn, M Israel, L Liotta, PM Howley
    • Kern SE. Progressive genetic abnormalities in human neoplasia. In: Molecular basis of Cancer. Eds; J Mendelsohn, M Israel, L Liotta, PM Howley.
    • Molecular Basis of Cancer
    • Kern, S.E.1
  • 4
    • 0031438047 scopus 로고    scopus 로고
    • TGF-b signaling from cell membrane to nucleus through SMAD proteins
    • Heldin, C. H., Miyazono, K., ten Dijke, P. TGF-b signaling from cell membrane to nucleus through SMAD proteins. Nature 1997;390:465-71.
    • (1997) Nature , vol.390 , pp. 465-471
    • Heldin, C.H.1    Miyazono, K.2    Ten Dijke, P.3
  • 5
    • 0032014216 scopus 로고    scopus 로고
    • Human Smad3 and Smad4 are sequence specific transcription activators
    • Zawel L, Dai JL, Buckhaults P et al. Human Smad3 and Smad4 are sequence specific transcription activators. Mol Cell 1998;1:611-7.
    • (1998) Mol Cell , vol.1 , pp. 611-617
    • Zawel, L.1    Dai, J.L.2    Buckhaults, P.3
  • 6
    • 0030963943 scopus 로고    scopus 로고
    • DPC4 (SMAD4) mediates transforming growth factor-beta1 (TGF-beta1) induced growth inhibition and transcriptional response in breast tumour cells
    • de Winter JP, Roelen BA, ten Dijke P et al. DPC4 (SMAD4) mediates transforming growth factor-beta1 (TGF-beta1) induced growth inhibition and transcriptional response in breast tumour cells. Oncogene 1997;14:1891-9.
    • (1997) Oncogene , vol.14 , pp. 1891-1899
    • De Winter, J.P.1    Roelen, B.A.2    Ten Dijke, P.3
  • 7
    • 0031303927 scopus 로고    scopus 로고
    • Transforming growth factor-beta and cancer: A love-hate relationship?
    • Reiss M. Transforming growth factor-beta and cancer: a love-hate relationship? Oncology Research.9:447-57, 1997
    • (1997) Oncology Research , vol.9 , pp. 447-457
    • Reiss, M.1
  • 8
    • 0030593038 scopus 로고    scopus 로고
    • DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1
    • Hahn, S. A., Schutte, M., Hoque, A. T. M. S. et al. DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science 1996;271:350-3,.
    • (1996) Science , vol.271 , pp. 350-353
    • Hahn, S.A.1    Schutte, M.2    Hoque, A.T.M.S.3
  • 9
    • 9344223357 scopus 로고    scopus 로고
    • DPC4 gene in various tumor types
    • Schutte, M., Hruban, R. H., Hedrick, L. et al. DPC4 gene in various tumor types. Cancer Res. 56, 2527-30 1996.
    • (1996) Cancer Res. , vol.56 , pp. 2527-2530
    • Schutte, M.1    Hruban, R.H.2    Hedrick, L.3
  • 10
    • 0344652354 scopus 로고    scopus 로고
    • Genetic alterations of the TGFb receptor genes in pancreatic and biliary adenocarcinomas
    • in press
    • Goggins M, Shekher M, Turnaniglu K et al. Genetic alterations of the TGFb receptor genes in pancreatic and biliary adenocarcinomas. Cancer Research 1998: in press.
    • (1998) Cancer Research
    • Goggins, M.1    Shekher, M.2    Turnaniglu, K.3
  • 11
    • 0029066689 scopus 로고
    • Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability
    • Markowitz, S., Wang, J., Myeroff, L. et al. Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability. Science. 268: 1336-38 1995.
    • (1995) Science , vol.268 , pp. 1336-1338
    • Markowitz, S.1    Wang, J.2    Myeroff, L.3
  • 12
    • 0029114477 scopus 로고
    • Missense mutations of the transforming growth factor b type II receptor in human head and neck squamous carcinoma cells
    • Garrigue-Antar, L., Munoz-Antonia, T., Antonia, S.J. et al. Missense mutations of the transforming growth factor b type II receptor in human head and neck squamous carcinoma cells. Cancer Res 1995;55:3982-7.
    • (1995) Cancer Res , vol.55 , pp. 3982-3987
    • Garrigue-Antar, L.1    Munoz-Antonia, T.2    Antonia, S.J.3
  • 14
    • 16044369574 scopus 로고    scopus 로고
    • MADR2 maps to 18q21 and encodes a TGF-b-regulated MAD-related protein that is functionally mutated in colorectal carcinoma
    • Eppert, K., Scherer, S.W., Ozcelik, H. et al. MADR2 maps to 18q21 and encodes a TGF-b-regulated MAD-related protein that is functionally mutated in colorectal carcinoma. Cell 86;543-52: 1996
    • (1996) Cell , vol.86 , pp. 543-552
    • Eppert, K.1    Scherer, S.W.2    Ozcelik, H.3
  • 15
    • 0032520915 scopus 로고    scopus 로고
    • Mutations of the DPC4/Smad4 gene in biliary tract carcinoma
    • Hahn SA, Bartsch D, Schroers A. et al. Mutations of the DPC4/Smad4 gene in biliary tract carcinoma. Cancer Res 1998;58:1124-6.
    • (1998) Cancer Res , vol.58 , pp. 1124-1126
    • Hahn, S.A.1    Bartsch, D.2    Schroers, A.3
  • 16
    • 15844390729 scopus 로고    scopus 로고
    • Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers
    • Thiagalingam S, Lengauer C, Leach FS et al. Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers. Nat Genet 1996;13:343-6.
    • (1996) Nat Genet , vol.13 , pp. 343-346
    • Thiagalingam, S.1    Lengauer, C.2    Leach, F.S.3
  • 17
    • 0029810920 scopus 로고    scopus 로고
    • Attenuated ALK5 receptor expression in human pancreatic cancer: Correlation with resistance to growth inhibition
    • Baldwin RL, Friess H, Yokoyama M et al. Attenuated ALK5 receptor expression in human pancreatic cancer: correlation with resistance to growth inhibition. Int J Cancer 1996;67:283-8..
    • (1996) Int J Cancer , vol.67 , pp. 283-288
    • Baldwin, R.L.1    Friess, H.2    Yokoyama, M.3
  • 18
    • 0029054399 scopus 로고
    • Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16
    • Lukas J, Parry D, Aagaard L et al. Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16. Nature 1995;375:503-6
    • (1995) Nature , vol.375 , pp. 503-506
    • Lukas, J.1    Parry, D.2    Aagaard, L.3
  • 19
    • 0029849620 scopus 로고    scopus 로고
    • Cancer cell cycles
    • Scherr CJ. Cancer cell cycles. Science 1996;274:1672-7.
    • (1996) Science , vol.274 , pp. 1672-1677
    • Scherr, C.J.1
  • 20
    • 0028085975 scopus 로고
    • Analysis of the p16 gene (CDKN2) as a candidate for the chromosome 9p melanoma susceptibility locus
    • Kamb A, Shattuck-Eidens D, Eeles R et al. Analysis of the p16 gene (CDKN2) as a candidate for the chromosome 9p melanoma susceptibility locus. Nature Genetics 1994;8:23-6.
    • (1994) Nature Genetics , vol.8 , pp. 23-26
    • Kamb, A.1    Shattuck-Eidens, D.2    Eeles, R.3
  • 21
    • 0029129816 scopus 로고
    • Increased risk of pancreatic cancer in melanoma-prone kindreds with p16INK4 mutations
    • Goldstein AM, Fraser MC, Struewing JP et al. Increased risk of pancreatic cancer in melanoma-prone kindreds with p16INK4 mutations. N Engl J Med 1995;333: 970-74.
    • (1995) N Engl J Med , vol.333 , pp. 970-974
    • Goldstein, A.M.1    Fraser, M.C.2    Struewing, J.P.3
  • 22
    • 0028059330 scopus 로고
    • Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma
    • Caldas C, Hahn SA, da Costa LT et al. Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma. Nature Genetics 1994;8:27-31
    • (1994) Nature Genetics , vol.8 , pp. 27-31
    • Caldas, C.1    Hahn, S.A.2    Da Costa, L.T.3
  • 23
    • 16944367477 scopus 로고    scopus 로고
    • Abrogation of the Rb/p16 tumor-suppressive pathway in virtually all pancreatic carcinomas
    • Schutte M, Hruban RH, Geradts J et al. Abrogation of the Rb/p16 tumor-suppressive pathway in virtually all pancreatic carcinomas. Cancer Res 1997;57:3126-30.
    • (1997) Cancer Res , vol.57 , pp. 3126-3130
    • Schutte, M.1    Hruban, R.H.2    Geradts, J.3
  • 24
    • 0025894713 scopus 로고
    • p53 mutations in human cancers
    • Hollstein M, Sidransky D, Vogelstein B et al. p53 mutations in human cancers. Science 1991;253(5015):49-53.
    • (1991) Science , vol.253 , Issue.5015 , pp. 49-53
    • Hollstein, M.1    Sidransky, D.2    Vogelstein, B.3
  • 25
    • 14444284330 scopus 로고    scopus 로고
    • Tumor-suppressive pathways in pancreatic carcinoma
    • Rozenblum E, Schutte M, Goggins M et al. Tumor-suppressive pathways in pancreatic carcinoma. Cancer Res 1997;57:1731-4.
    • (1997) Cancer Res , vol.57 , pp. 1731-1734
    • Rozenblum, E.1    Schutte, M.2    Goggins, M.3
  • 26
    • 0028308492 scopus 로고
    • p53 mutations in pancreatic carcinoma and evidence of common involvement of homocopolymer tracts in DNA microdeletions
    • Redston MS, Caldas C, Seymour AB et al. p53 mutations in pancreatic carcinoma and evidence of common involvement of homocopolymer tracts in DNA microdeletions. Cancer Res 1994;54:3025-33.
    • (1994) Cancer Res , vol.54 , pp. 3025-3033
    • Redston, M.S.1    Caldas, C.2    Seymour, A.B.3
  • 27
    • 0030941458 scopus 로고    scopus 로고
    • p53, the cellular gatekeeper for growth and division
    • Levine AJ. p53, the cellular gatekeeper for growth and division. Cell 1997;88:323-31.
    • (1997) Cell , vol.88 , pp. 323-331
    • Levine, A.J.1
  • 28
    • 0032549711 scopus 로고    scopus 로고
    • ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
    • Zhang Y, Xiong Y, Yarbrough WG. ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways. Cell 1998;92:725-34.
    • (1998) Cell , vol.92 , pp. 725-734
    • Zhang, Y.1    Xiong, Y.2    Yarbrough, W.G.3
  • 29
    • 0032549704 scopus 로고    scopus 로고
    • The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53
    • Pomerantz J, Schreiber-Agus N, Liegeois NJ et al. The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53. Cell 1998;92:713-23.
    • (1998) Cell , vol.92 , pp. 713-723
    • Pomerantz, J.1    Schreiber-Agus, N.2    Liegeois, N.J.3
  • 30
    • 0030728468 scopus 로고    scopus 로고
    • Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF
    • Kamijo T, Zindy F, Roussel MF et al. Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF. Cell 1997;91:649-59
    • (1997) Cell , vol.91 , pp. 649-659
    • Kamijo, T.1    Zindy, F.2    Roussel, M.F.3
  • 31
    • 0028110809 scopus 로고
    • Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status
    • Graeber TG, Peterson JF, Tsai M et al. Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status. Mol Cell Biol 1994;14:6264-77.
    • (1994) Mol Cell Biol , vol.14 , pp. 6264-6277
    • Graeber, T.G.1    Peterson, J.F.2    Tsai, M.3
  • 32
    • 0032568150 scopus 로고    scopus 로고
    • Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha
    • An WG, Kanekal M, Simon MC et al. Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha. Nature 1998;392:405-8.
    • (1998) Nature , vol.392 , pp. 405-408
    • An, W.G.1    Kanekal, M.2    Simon, M.C.3
  • 33
    • 0032581277 scopus 로고    scopus 로고
    • Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
    • Carmeliet P, Dor Y, Herbert JM et al. Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature 1998;394:485-90.
    • (1998) Nature , vol.394 , pp. 485-490
    • Carmeliet, P.1    Dor, Y.2    Herbert, J.M.3
  • 34
    • 0030025773 scopus 로고    scopus 로고
    • Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours
    • Graeber TG, Osmanian C, Jacks T et al. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature 1996;379:88-91.
    • (1996) Nature , vol.379 , pp. 88-91
    • Graeber, T.G.1    Osmanian, C.2    Jacks, T.3
  • 35
    • 0030930366 scopus 로고    scopus 로고
    • A model for p53-induced apoptosis
    • Polyak, K Xia Y, Zweier JL et al. A model for p53-induced apoptosis Nature 1997;389: 300-5
    • (1997) Nature , vol.389 , pp. 300-305
    • Polyak, K.1    Xia, Y.2    Zweier, J.L.3
  • 36
    • 0031310665 scopus 로고    scopus 로고
    • 14-3-3 sigma is a p53-regulated inhibitor of G2/M progression
    • Hermeking H, Lengauer C, Polyak K et al. 14-3-3 sigma is a p53-regulated inhibitor of G2/M progression. Mol Cell 1997;1:3-11
    • (1997) Mol Cell , vol.1 , pp. 3-11
    • Hermeking, H.1    Lengauer, C.2    Polyak, K.3
  • 37
    • 0032553485 scopus 로고    scopus 로고
    • Requirement for p53 and p21 to sustain G2 arrest after DNA damage
    • Bunz F, Dutriaux A, Lengauer C et al. Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science 1998: 1497-1501.
    • Science , vol.1998 , pp. 1497-1501
    • Bunz, F.1    Dutriaux, A.2    Lengauer, C.3
  • 38
    • 0031840253 scopus 로고    scopus 로고
    • ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins
    • Waterman MJF, Stavridi ES, Waterman JLF et al. ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins. Nat Genet 1998;19:175-8
    • (1998) Nat Genet , vol.19 , pp. 175-178
    • Waterman, M.J.F.1    Stavridi, E.S.2    Waterman, J.L.F.3
  • 39
    • 0032101647 scopus 로고    scopus 로고
    • Adenovirus-mediated Wild-Type p53 Gene Transfer Down-Regulates Vascular Endothelial Growth Factor Expression and Inhibits Angiogenesis in Human Colon Cancer
    • Bouvet M, Ellis LE, Nishizaki M et al. Adenovirus-mediated Wild-Type p53 Gene Transfer Down-Regulates Vascular Endothelial Growth Factor Expression and Inhibits Angiogenesis in Human Colon Cancer. Cancer Res 1998;58:2288-92
    • (1998) Cancer Res , vol.58 , pp. 2288-2292
    • Bouvet, M.1    Ellis, L.E.2    Nishizaki, M.3
  • 41
    • 0031736203 scopus 로고    scopus 로고
    • Somatic mutations of the mitochondrial genome in human colorectal tumors
    • Polyak K, Li Y, Zhu H et al. Somatic mutations of the mitochondrial genome in human colorectal tumors. Nature Genet 1998;20:291-3.
    • (1998) Nature Genet , vol.20 , pp. 291-293
    • Polyak, K.1    Li, Y.2    Zhu, H.3
  • 42
    • 0030933762 scopus 로고    scopus 로고
    • Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2
    • Sharan SK, Morimatsu M, Albrecht U et al. Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2. Nature 1997;386:804-10.
    • (1997) Nature , vol.386 , pp. 804-810
    • Sharan, S.K.1    Morimatsu, M.2    Albrecht, U.3
  • 43
    • 0032126029 scopus 로고    scopus 로고
    • Double-strand break repair deficiency and radiation sensitivity in BRCA2 mutant cancer cells
    • Abbott DW, Freeman ML, Holt JT. Double-strand break repair deficiency and radiation sensitivity in BRCA2 mutant cancer cells. J Natl Can Inst 1998;90:978-85.
    • (1998) J Natl Can Inst , vol.90 , pp. 978-985
    • Abbott, D.W.1    Freeman, M.L.2    Holt, J.T.3
  • 44
    • 0030910022 scopus 로고    scopus 로고
    • The risk of cancer associated with specific mutations of BRCA1 and BRCA2 among Ashkenazi Jews
    • Struewing JP, Hartge P, Wacholder S et al. The risk of cancer associated with specific mutations of BRCA1 and BRCA2 among Ashkenazi Jews. N Engl J Med 1997;336:1401-8
    • (1997) N Engl J Med , vol.336 , pp. 1401-1408
    • Struewing, J.P.1    Hartge, P.2    Wacholder, S.3
  • 45
    • 12644253827 scopus 로고    scopus 로고
    • Germline BRCA2 gene mutations in patients with apparently sporadic pancreatic carcinomas
    • Goggins M, Schutte M, Lu J et al. Germline BRCA2 gene mutations in patients with apparently sporadic pancreatic carcinomas. Cancer Res 1996;56:5360-4
    • (1996) Cancer Res , vol.56 , pp. 5360-5364
    • Goggins, M.1    Schutte, M.2    Lu, J.3
  • 46
    • 0031137173 scopus 로고    scopus 로고
    • Germline BRCA2 6174delT mutations in Ashkenazi Jewish pancreatic cancer patients
    • Ozcelik H, Schmocker B, Di Nicola N et al. Germline BRCA2 6174delT mutations in Ashkenazi Jewish pancreatic cancer patients. Nat Genet 1997;16:17-8.
    • (1997) Nat Genet , vol.16 , pp. 17-18
    • Ozcelik, H.1    Schmocker, B.2    Di Nicola, N.3
  • 47
    • 16044366171 scopus 로고    scopus 로고
    • Offit Frequency of recurrent BRCA1 and BRCA2 mutations in Ashkenazi Jewish breast cancer families
    • Tonin P, Weber B. Offit Frequency of recurrent BRCA1 and BRCA2 mutations in Ashkenazi Jewish breast cancer families. Nat Med. 1996;2:1179-83
    • (1996) Nat Med. , vol.2 , pp. 1179-1183
    • Tonin, P.1    Weber, B.2
  • 48
    • 0023192463 scopus 로고
    • Increased risk of cancer in the Peutz-Jeghers syndrome
    • Giardiello FM, Welsh SB, Hamilton SR et al. Increased risk of cancer in the Peutz-Jeghers syndrome. N Engl J Med 1987;316:1511-4
    • (1987) N Engl J Med , vol.316 , pp. 1511-1514
    • Giardiello, F.M.1    Welsh, S.B.2    Hamilton, S.R.3
  • 50
    • 0030975440 scopus 로고    scopus 로고
    • Hereditary pancreatitis and the risk of pancreatic cancer
    • International Hereditary Pancreatitis Study Group
    • Lowenfels AB, Maisonneuve P, DiMagno EP et al. Hereditary pancreatitis and the risk of pancreatic cancer. International Hereditary Pancreatitis Study Group. J Natl Cancer Instit 1997;89:442-6.
    • (1997) J Natl Cancer Instit , vol.89 , pp. 442-446
    • Lowenfels, A.B.1    Maisonneuve, P.2    DiMagno, E.P.3
  • 51
    • 10144246566 scopus 로고    scopus 로고
    • Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene
    • Whitcomb DC, Gorry MC, Preston RA et al. Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene Nature Genetics 1996;14:141-5
    • (1996) Nature Genetics , vol.14 , pp. 141-145
    • Whitcomb, D.C.1    Gorry, M.C.2    Preston, R.A.3
  • 52
    • 0032100617 scopus 로고    scopus 로고
    • Alternations in pancreatic, biliary, and breast carcinomas support MKK4 as a genetically targeted tumor suppressor gene
    • Su, G. H., Hilgers, W., Shekher, M. et al. Alternations in pancreatic, biliary, and breast carcinomas support MKK4 as a genetically targeted tumor suppressor gene. Cancer Res. 58: 2339-42 1998.
    • (1998) Cancer Res. , vol.58 , pp. 2339-2342
    • Su, G.H.1    Hilgers, W.2    Shekher, M.3
  • 53
    • 0002600106 scopus 로고    scopus 로고
    • Normal beta-catenin gene in pancreatic cancer
    • Goggins M, Hilgers W, Hruban RH et al. Normal beta-catenin gene in pancreatic cancer. NOGO 1997;1:4.
    • (1997) NOGO , vol.1 , pp. 4
    • Goggins, M.1    Hilgers, W.2    Hruban, R.H.3
  • 54
    • 0032006029 scopus 로고    scopus 로고
    • Analysis of PTEN/MMAC1 alterations in aerodigestive tract tumors
    • Okami K, Wu L, Riggins G et al. Analysis of PTEN/MMAC1 alterations in aerodigestive tract tumors. Cancer Res 1998;58:509-11
    • (1998) Cancer Res , vol.58 , pp. 509-511
    • Okami, K.1    Wu, L.2    Riggins, G.3
  • 55
    • 0024292722 scopus 로고
    • Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes
    • Almoguerra C, Shibata D, Forrester K et al. Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes. Cell 1988;53:549-54
    • (1988) Cell , vol.53 , pp. 549-554
    • Almoguerra, C.1    Shibata, D.2    Forrester, K.3
  • 56
    • 0027733796 scopus 로고
    • K-ras oncogene activation in adenocarcinomas of the human pancreas: A study of 82 carcinomas using a combination of mutant-enriched polymerase chain reaction analysis and allele-specific oligonucleotide hybridization
    • Hruban RH, van Mansfeld ADM, Offerhaus GJA et al. K-ras oncogene activation in adenocarcinomas of the human pancreas: a study of 82 carcinomas using a combination of mutant-enriched polymerase chain reaction analysis and allele-specific oligonucleotide hybridization. Am J Pathol 1993;143:545-54
    • (1993) Am J Pathol , vol.143 , pp. 545-554
    • Hruban, R.H.1    Van Mansfeld, A.D.M.2    Offerhaus, G.J.A.3
  • 57
    • 0030030897 scopus 로고    scopus 로고
    • Immunohistochemical evaluation of HER2/neu expression in pancreatic adenocarcinoma and pancreatic intraepithelial neoplasms
    • Day JD, Digiuseppe JA, Yeo C et al. Immunohistochemical evaluation of HER2/neu expression in pancreatic adenocarcinoma and pancreatic intraepithelial neoplasms. Human Pathology 1996;27:119-24
    • (1996) Human Pathology , vol.27 , pp. 119-124
    • Day, J.D.1    Digiuseppe, J.A.2    Yeo, C.3
  • 58
    • 17644430199 scopus 로고    scopus 로고
    • Adenocarcinomas of the pancreas with DNa replication errors (RER+) are associated with a characteristic histopathology: Poor differentiation, a syncytial growth pattern, and pushing borders suggest RER
    • Goggins, M., Offerhaus, G. J. A., Hilgers, W. et al. Adenocarcinomas of the pancreas with DNA replication errors (RER+) are associated with a characteristic histopathology: poor differentiation, a syncytial growth pattern, and pushing borders suggest RER. Am J Pathol 1998;152:1501-7.
    • (1998) Am J Pathol , vol.152 , pp. 1501-1507
    • Goggins, M.1    Offerhaus, G.J.A.2    Hilgers, W.3
  • 59
    • 0026026239 scopus 로고
    • Ras gene mutations in intraductal papillary neoplasms of the pancreas. Analysis in five cases
    • Tada M, Omata M, Ohto M. Ras gene mutations in intraductal papillary neoplasms of the pancreas. Analysis in five cases. Cancer 1991;67:634-7
    • (1991) Cancer , vol.67 , pp. 634-637
    • Tada, M.1    Omata, M.2    Ohto, M.3
  • 60
    • 0028342395 scopus 로고
    • Detection of K-ras mutations in the stool of patients with pancreatic adenocarcinoma and pancreatic ductal hyperplasia
    • Caldas C, Hahn SA, Hruban RH et al. Detection of K-ras mutations in the stool of patients with pancreatic adenocarcinoma and pancreatic ductal hyperplasia. Cancer Res 1994;54:3568-73
    • (1994) Cancer Res , vol.54 , pp. 3568-3573
    • Caldas, C.1    Hahn, S.A.2    Hruban, R.H.3
  • 61
    • 17344377380 scopus 로고    scopus 로고
    • Detection of K-ras gene mutations in plasma DNA of patients with pancreatic adenocarcinoma: Correlation with clinicopathological features
    • Yamada T, Nakamori S, Ohzato H et al. Detection of K-ras gene mutations in plasma DNA of patients with pancreatic adenocarcinoma: correlation with clinicopathological features. Clinical Cancer Research 1998;4:1527-32.
    • (1998) Clinical Cancer Research , vol.4 , pp. 1527-1532
    • Yamada, T.1    Nakamori, S.2    Ohzato, H.3
  • 62
    • 0031938490 scopus 로고    scopus 로고
    • A prospective study of K-ras mutations in the plasma of pancreatic cancer patients
    • Mulcahy HE, Lyautey J, Lederrey C et al. A prospective study of K-ras mutations in the plasma of pancreatic cancer patients. Clinical Cancer Research 1998;4:271-5.
    • (1998) Clinical Cancer Research , vol.4 , pp. 271-275
    • Mulcahy, H.E.1    Lyautey, J.2    Lederrey, C.3
  • 63
    • 0031893736 scopus 로고    scopus 로고
    • K-ras mutations in the duodenal fluid of patients with pancreatic carcinoma
    • Wilentz RE, Chung CH, Sturm PD et al. K-ras mutations in the duodenal fluid of patients with pancreatic carcinoma. Cancer 1998;82:96-103
    • (1998) Cancer , vol.82 , pp. 96-103
    • Wilentz, R.E.1    Chung, C.H.2    Sturm, P.D.3
  • 65
    • 14344254868 scopus 로고    scopus 로고
    • Antitumor activity of SCH 66336, an orally bioavailable tricyclic inhibitor of farnesyl protein transferase, in human tumor xenograft models and wap-ras transgenic mice
    • Liu M, Bryant MS, Chen J et al. Antitumor activity of SCH 66336, an orally bioavailable tricyclic inhibitor of farnesyl protein transferase, in human tumor xenograft models and wap-ras transgenic mice. Cancer Res 1998;58:4947-56
    • (1998) Cancer Res , vol.58 , pp. 4947-4956
    • Liu, M.1    Bryant, M.S.2    Chen, J.3
  • 66
    • 0025848680 scopus 로고
    • The international collaborative group on hereditary nonpolyposis colorectal cancer (ICG-HNPCC)
    • Vasen HFA, Mecklin JP, Meera Khan P et al. The international collaborative group on hereditary nonpolyposis colorectal cancer (ICG-HNPCC). Dis Colon Rectum 1991;34:424-5
    • (1991) Dis Colon Rectum , vol.34 , pp. 424-425
    • Vasen, H.F.A.1    Mecklin, J.P.2    Meera Khan, P.3
  • 67
    • 0029915034 scopus 로고    scopus 로고
    • Overview of natural history, pathology, molecular genetics and management of HNPCC (Lynch Syndrome)
    • Lynch HT, Smyrk TC, Lynch JF. Overview of natural history, pathology, molecular genetics and management of HNPCC (Lynch Syndrome). Int J Cancer 1996;69:38-43.
    • (1996) Int J Cancer , vol.69 , pp. 38-43
    • Lynch, H.T.1    Smyrk, T.C.2    Lynch, J.F.3
  • 68
    • 0002608599 scopus 로고    scopus 로고
    • Hereditary non-polyposis colorectal cancer
    • Eds: Vogelstein B, and Kinzler K. MacGraw Hill
    • Boland CR. Hereditary non-polyposis colorectal cancer. In: The genetic basis of human cancer, pgs. 333-346. Eds: Vogelstein B, and Kinzler K. MacGraw Hill, 1998.
    • (1998) The Genetic Basis of Human Cancer , pp. 333-346
    • Boland, C.R.1
  • 69
    • 0027943743 scopus 로고
    • Pathology of hereditary nonpolyposis colon cancer
    • Jass JR, Smyrk TC, Stewart SM et al. Pathology of hereditary nonpolyposis colon cancer. Anticancer Res 1994;14:1631-34.
    • (1994) Anticancer Res , vol.14 , pp. 1631-1634
    • Jass, J.R.1    Smyrk, T.C.2    Stewart, S.M.3
  • 70
    • 0028276666 scopus 로고
    • Clinical and pathological characteristics of sporadic colorectal carcinomas with DNA replication errors in microsatellite sequences
    • Kim H, Jen J, Vogelstein B et al. Clinical and pathological characteristics of sporadic colorectal carcinomas with DNA replication errors in microsatellite sequences. Am J Pathol 1994;145:148-156.
    • (1994) Am J Pathol , vol.145 , pp. 148-156
    • Kim, H.1    Jen, J.2    Vogelstein, B.3
  • 71
    • 0025232703 scopus 로고
    • Diploid predominance in hereditary nonpolyposis colorectal carcinoma evaluated by flow cytometry
    • Kouri M, Laasonen A, Mecklin JP et al. Diploid predominance in hereditary nonpolyposis colorectal carcinoma evaluated by flow cytometry. Cancer 1989;65:1825-9.
    • (1989) Cancer , vol.65 , pp. 1825-1829
    • Kouri, M.1    Laasonen, A.2    Mecklin, J.P.3
  • 72
    • 0031004175 scopus 로고    scopus 로고
    • Genetic instability in colorectal cancers
    • Lengauer C, Kinzler KW, Vogelstein B. Genetic instability in colorectal cancers. Nature 1997;386:623-7.
    • (1997) Nature , vol.386 , pp. 623-627
    • Lengauer, C.1    Kinzler, K.W.2    Vogelstein, B.3
  • 73
    • 0032546360 scopus 로고    scopus 로고
    • Mutations of mitotic checkpoint genes in human cancers
    • Cahill DP, Lengauer C, Yu J et al. Mutations of mitotic checkpoint genes in human cancers Nature 1998;392:300-3
    • (1998) Nature , vol.392 , pp. 300-303
    • Cahill, D.P.1    Lengauer, C.2    Yu, J.3
  • 74
    • 0020699979 scopus 로고
    • Hypomethylation distinguishes genes of some human cancers from their normal counterparts
    • Feinberg AP, Vogelstein B. Hypomethylation distinguishes genes of some human cancers from their normal counterparts. Nature 1983;301:89-92.
    • (1983) Nature , vol.301 , pp. 89-92
    • Feinberg, A.P.1    Vogelstein, B.2
  • 75
    • 0021950948 scopus 로고
    • Hypomethylation of DNA from benign and malignant human colon neoplasms
    • Goelz SE, Vogelstein B, Hamilton SR et al. Hypomethylation of DNA from benign and malignant human colon neoplasms. Science 1985;228:187-90
    • (1985) Science , vol.228 , pp. 187-190
    • Goelz, S.E.1    Vogelstein, B.2    Hamilton, S.R.3
  • 76
    • 0030983076 scopus 로고    scopus 로고
    • DNA methylation and genetic instability in colorectal cancer cells
    • Lengauer C, Kinzler KW, Vogelstein B. DNA methylation and genetic instability in colorectal cancer cells. Proc Natl Acad Sci U S A 1997;94:2545-50.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 2545-2550
    • Lengauer, C.1    Kinzler, K.W.2    Vogelstein, B.3
  • 77
    • 0032480226 scopus 로고    scopus 로고
    • DNA hypomethylation leads to elevated mutation rates
    • R Z Chen, U Pettersson, C Beard et al. DNA hypomethylation leads to elevated mutation rates Nature 1998;395:089
    • (1998) Nature , vol.395 , pp. 089
    • Chen, R.Z.1    Pettersson, U.2    Beard, C.3
  • 78
    • 0030846212 scopus 로고    scopus 로고
    • Alterations in DNa methylation: A fundamental aspect of neoplasia
    • Baylin SB, Herman JG, Graff JR et al. Alterations in DNA methylation: a fundamental aspect of neoplasia. Adv Cancer Res 1998;72:141-96
    • (1998) Adv Cancer Res , vol.72 , pp. 141-196
    • Baylin, S.B.1    Herman, J.G.2    Graff, J.R.3
  • 79
    • 0002051541 scopus 로고    scopus 로고
    • Genomic imprinting and cancer
    • Eds: Vogelstein B, and Kinzler K. MacGraw Hill
    • Feinberg AP. Genomic imprinting and cancer. In: The genetic basis of human cancer, pgs 95-108. Eds: Vogelstein B, and Kinzler K. MacGraw Hill 1998.
    • (1998) The Genetic Basis of Human Cancer , pp. 95-108
    • Feinberg, A.P.1
  • 80
    • 0031761362 scopus 로고    scopus 로고
    • Loss of imprinting in normal tissue of colorectal cancer patients with microsatellite instability
    • Cui H, Horon IL, Ohlsson R et al. Loss of imprinting in normal tissue of colorectal cancer patients with microsatellite instability. Nature Med 1998;4:1276-80.
    • (1998) Nature Med , vol.4 , pp. 1276-1280
    • Cui, H.1    Horon, I.L.2    Ohlsson, R.3
  • 81
    • 0028875562 scopus 로고
    • Allelotype of pancreatic adenocarcinoma using a xenograft model
    • Hahn SA, Seymour AB, Hoque ATMS et al. Allelotype of pancreatic adenocarcinoma using a xenograft model. Cancer Res 1995;55:4670-5.
    • (1995) Cancer Res , vol.55 , pp. 4670-4675
    • Hahn, S.A.1    Seymour, A.B.2    Hoque, A.T.M.S.3
  • 82
    • 0029001472 scopus 로고
    • Consistent chromosome abnormalities in adenocarcinoma of the pancreas
    • Griffin CA, Hruban RH, Morsberger LA et al. Consistent chromosome abnormalities in adenocarcinoma of the pancreas. Cancer Res 1995;55:2394-9
    • (1995) Cancer Res , vol.55 , pp. 2394-2399
    • Griffin, C.A.1    Hruban, R.H.2    Morsberger, L.A.3
  • 83
    • 0030598884 scopus 로고    scopus 로고
    • Isolation of DNA sequences amplified at chromosome 19q13.1-q13.2 including the AKT2 locus in human pancreatic cancer
    • Miwa W, Yasuda J, Murakami Y et al. Isolation of DNA sequences amplified at chromosome 19q13.1-q13.2 including the AKT2 locus in human pancreatic cancer. Biochem Biophys Res Commun 1996;225:968-74.
    • (1996) Biochem Biophys Res Commun , vol.225 , pp. 968-974
    • Miwa, W.1    Yasuda, J.2    Murakami, Y.3
  • 84
    • 0001457668 scopus 로고    scopus 로고
    • Amplification of AKT2 in human pancreatic cancer cells and inhibition of AKT2 expression and tumorigenecity by antisense RNA
    • Cheng JQ, Ruggeri B, Klein WM et al. Amplification of AKT2 in human pancreatic cancer cells and inhibition of AKT2 expression and tumorigenecity by antisense RNA. Proc Natl Acad Sci USA 1996;93:3636-41.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 3636-3641
    • Cheng, J.Q.1    Ruggeri, B.2    Klein, W.M.3
  • 85
    • 0030795405 scopus 로고    scopus 로고
    • Characterization of a high copy number amplification at 6q24 in pancreatic cancer identifies c-myb as a candidate oncogene
    • Wallrapp C, Muller-Pillasch F, Solinas-Toldo S et al. Characterization of a high copy number amplification at 6q24 in pancreatic cancer identifies c-myb as a candidate oncogene. Cancer Res 1997;57:3135-9.
    • (1997) Cancer Res , vol.57 , pp. 3135-3139
    • Wallrapp, C.1    Muller-Pillasch, F.2    Solinas-Toldo, S.3
  • 86
    • 0028564951 scopus 로고
    • Specific association of human telomerase activity with immortal cells and cancer
    • Kim NW, Piatyszek MA, Prowse KR et al. Specific association of human telomerase activity with immortal cells and cancer. Science 1994;266:2011-5
    • (1994) Science , vol.266 , pp. 2011-2015
    • Kim, N.W.1    Piatyszek, M.A.2    Prowse, K.R.3
  • 87
    • 0031015729 scopus 로고    scopus 로고
    • Telomerase activity is detected in pancreatic cancer but not in benign tumors
    • Hiyama E, Kodama T, Shinbara K et al. Telomerase activity is detected in pancreatic cancer but not in benign tumors. Cancer Res 1997;57:326-31.
    • (1997) Cancer Res , vol.57 , pp. 326-331
    • Hiyama, E.1    Kodama, T.2    Shinbara, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.