-
1
-
-
33846457870
-
Cancer statistics, 2007
-
Jemal A, Siegel R, Ward E, Murray T, Xu J, Thun MJ. Cancer statistics, 2007. CA Cancer J Clin 2007; 57: 43-66
-
(2007)
CA Cancer J Clin
, vol.57
, pp. 43-66
-
-
Jemal, A.1
Siegel, R.2
Ward, E.3
Murray, T.4
Xu, J.5
Thun, M.J.6
-
2
-
-
47949117602
-
Pancreatic cancer: From molecular pathogenesis to targeted therapy
-
Strimpakos A, Saif MW, Syrigos KN. Pancreatic cancer: from molecular pathogenesis to targeted therapy. Cancer Metastasis Rev 2008; 27: 495-522
-
(2008)
Cancer Metastasis Rev
, vol.27
, pp. 495-522
-
-
Strimpakos, A.1
Saif, M.W.2
Syrigos, K.N.3
-
3
-
-
39049173392
-
The role of adjuvant chemotherapy for patients with resected pancreatic cancer: Systematic review of randomized controlled trials and meta-analysis
-
DOI 10.1159/000113054
-
Boeck S, Ankerst DP, Heinemann V. The role of adjuvant chemotherapy for patients with resected pancreatic cancer: systematic review of randomized controlled trials and metaanalysis. Oncology 2007; 72: 314-321 (Pubitemid 351238143)
-
(2007)
Oncology
, vol.72
, Issue.5-6
, pp. 314-321
-
-
Boeck, S.1
Ankerst, D.P.2
Heinemann, V.3
-
5
-
-
33947417336
-
Regulation of metastases by signal transducer and activator of transcription 3 signaling pathway: Clinical implications
-
DOI 10.1158/1078-0432.CCR-06-2313
-
Huang S. Regulation of metastases by signal transducer and activator of transcription 3 signaling pathway: clinical implications. Clin Cancer Res 2007; 13: 1362-1366 (Pubitemid 46450423)
-
(2007)
Clinical Cancer Research
, vol.13
, Issue.5
, pp. 1362-1366
-
-
Huang, S.1
-
6
-
-
85047695527
-
Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis
-
DOI 10.1038/sj/onc/1205260
-
Niu G, Wright KL, Huang M, Song L, Haura E, Turkson J, Zhang S, Wang T, Sinibaldi D, Coppola D, Heller R, Ellis LM, Karras J, Bromberg J, Pardoll D, Jove R, Yu H. Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis. Oncogene 2002; 21: 2000-2008 (Pubitemid 34270888)
-
(2002)
Oncogene
, vol.21
, Issue.13
, pp. 2000-2008
-
-
Niu, G.1
Wright, K.L.2
Huang, M.3
Song, L.4
Haura, E.5
Turkson, J.6
Zhang, S.7
Wang, T.8
Sinibaldi, D.9
Coppola, D.10
Heller, R.11
Ellis, L.M.12
Karras, J.13
Bromberg, J.14
Pardoll, D.15
Jove, R.16
Yu, H.17
-
7
-
-
2442685645
-
Stat3 activation regulates the expression of matrix metalloproteinase-2 and tumor invasion and metastasis
-
DOI 10.1038/sj.onc.1207383
-
Xie TX, Wei D, Liu M, Gao AC, Ali-Osman F, Sawaya R, Huang S. Stat3 activation regulates the expression of matrix metalloproteinase-2 and tumor invasion and metastasis. Oncogene 2004; 23: 3550-3560 (Pubitemid 38658421)
-
(2004)
Oncogene
, vol.23
, Issue.20
, pp. 3550-3560
-
-
Xie, T.-X.1
Wei, D.2
Liu, M.3
Gao, A.C.4
Ali-Osman, F.5
Sawaya, R.6
Huang, S.7
-
8
-
-
33749046082
-
Activation of STAT3 in thymic epithelial tumours correlates with tumour type and clinical behaviour
-
DOI 10.1002/path.2041
-
Chang KC, Wu MH, Jones D, Chen FF, Tseng YL. Activation of STAT3 in thymic epithelial tumours correlates with tumour type and clinical behaviour. J Pathol 2006; 210: 224-233 (Pubitemid 44463937)
-
(2006)
Journal of Pathology
, vol.210
, Issue.2
, pp. 224-233
-
-
Chang, K.-C.1
Wu, M.-H.2
Jones, D.3
Chen, F.-F.4
Tseng, Y.-L.5
-
9
-
-
23444452377
-
Expression of p-STAT3 in human colorectal adenocarcinoma and adenoma; correlation with clinicopathological factors
-
DOI 10.1136/jcp.2004.023416
-
Kusaba T, Nakayama T, Yamazumi K, Yakata Y, Yoshizaki A, Nagayasu T, Sekine I. Expression of p-STAT3 in human colorectal adenocarcinoma and adenoma; correlation with clinicopathological factors. J Clin Pathol 2005; 58: 833-838 (Pubitemid 41113390)
-
(2005)
Journal of Clinical Pathology
, vol.58
, Issue.8
, pp. 833-838
-
-
Kusaba, T.1
Nakayama, T.2
Yamazumi, K.3
Yakata, Y.4
Yoshizaki, A.5
Nagayasu, T.6
Sekine, I.7
-
10
-
-
21044447810
-
Overexpression of phosphorylated-STAT3 correlated with the invasion and metastasis of cutaneous squamous cell carcinoma
-
Suiqing C, Min Z , Lirong C . Overexpression of phosphorylated-STAT3 correlated with the invasion and metastasis of cutaneous squamous cell carcinoma. J Dermatol 2005; 32: 354-360 (Pubitemid 40874460)
-
(2005)
Journal of Dermatology
, vol.32
, Issue.5
, pp. 354-360
-
-
Suiqing, C.1
Min, Z.2
Lirong, C.3
-
11
-
-
33750292431
-
Inhibition of STAT3 activity with AG490 decreases the invasion of human pancreatic cancer cells in vitro
-
DOI 10.1111/j.1349-7006.2006.00340.x
-
Huang C, Cao J, Huang KJ, Zhang F, Jiang T, Zhu L, Qiu ZJ. Inhibition of STAT3 activity with AG490 decreases the invasion of human pancreatic cancer cells in vitro. Cancer Sci 2006; 97: 1417-1423 (Pubitemid 44614996)
-
(2006)
Cancer Science
, vol.97
, Issue.12
, pp. 1417-1423
-
-
Huang, C.1
Cao, J.2
Huang, K.J.3
Zhang, F.4
Jiang, T.5
Zhu, L.6
Qiu, Z.J.7
-
12
-
-
0037134020
-
A system for stable expression of short interfering RNAs in mammalian cells
-
DOI 10.1126/science.1068999
-
Brummelkamp TR, Bernards R, Agami R. A system for stable expression of short interfering RNAs in mammalian cells. Science 2002; 296: 550-553 (Pubitemid 34408678)
-
(2002)
Science
, vol.296
, Issue.5567
, pp. 550-553
-
-
Brummelkamp, T.R.1
Bernards, R.2
Agami, R.3
-
13
-
-
0036726313
-
Stable suppression of tumorigenicity by virus-mediated RNA interference
-
DOI 10.1016/S1535-6108(02)00122-8
-
Brummelkamp TR, Bernards R, Agami R. Stable suppression of tumorigenicity by virus-mediated RNA interference. Cancer Cell 2002; 2: 243-247 (Pubitemid 41043979)
-
(2002)
Cancer Cell
, vol.2
, Issue.3
, pp. 243-247
-
-
Brummelkamp, T.R.1
Bernards, R.2
Agami, R.3
-
15
-
-
0037422583
-
Inhibiting HIV-1 infection in human T cells by lentiviral-mediated delivery of small interfering RNA against CCR5
-
Qin XF, An DS, Chen IS, Baltimore D. Inhibiting HIV-1 infection in human T cells by lentiviral-mediated delivery of small interfering RNA against CCR5. Proc Natl Acad Sci USA 2003; 100: 183-188
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 183-188
-
-
Qin, X.F.1
An, D.S.2
Chen, I.S.3
Baltimore, D.4
-
16
-
-
20844455902
-
Regulatory considerations for novel gene therapy products: A review of the process leading to the first clinical lentiviral vector
-
DOI 10.1089/hum.2005.16.17
-
Manilla P, Rebello T, Afable C, Lu X, Slepushkin V, Humeau LM, Schonely K, Ni Y, Binder GK, Levine BL, MacGregor RR, June CH, Dropulic B. Regulatory considerations for novel gene therapy products: a review of the process leading to the first clinical lentiviral vector. Hum Gene Ther 2005; 16: 17-25 (Pubitemid 40250328)
-
(2005)
Human Gene Therapy
, vol.16
, Issue.1
, pp. 17-25
-
-
Manilla, P.1
Rebello, T.2
Afable, C.3
Lu, X.4
Slepushkin, V.5
Humeau, L.M.6
Schonely, K.7
Ni, Y.8
Binder, G.K.9
Levine, B.L.10
Macgregor, R.-R.11
June, C.H.12
Dropulic, B.13
-
17
-
-
29744458522
-
A phase I/II clinical trial of beta-globin gene therapy for beta-thalassemia
-
DOI 10.1196/annals.1345.007
-
Bank A, Dorazio R, Leboulch P. A phase I/II clinical trial of beta-globin gene therapy for beta-thalassemia. Ann N Y Acad Sci 2005; 1054: 308-316 (Pubitemid 43031038)
-
(2005)
Annals of the New York Academy of Sciences
, vol.1054
, pp. 308-316
-
-
Bank, A.1
Dorazio, R.2
Leboulch, P.3
-
18
-
-
1642452660
-
Expression of small hairpin RNA by lentivirus-based vector confers efficient and stable gene-suppression of HIV-1 on human cells including primary non-dividing cells
-
DOI 10.1016/j.micinf.2003.10.009
-
Nishitsuji H, Ikeda T, Miyoshi H, Ohashi T, Kannagi M, Masuda T. Expression of small hairpin RNA by lentivirus-based vector confers efficient and stable gene-suppression of HIV-1 on human cells including primary non-dividing cells. Microbes Infect 2004; 6: 76-85 (Pubitemid 38114824)
-
(2004)
Microbes and Infection
, vol.6
, Issue.1
, pp. 76-85
-
-
Nishitsuji, H.1
Ikeda, T.2
Miyoshi, H.3
Ohashi, T.4
Kannagi, M.5
Masuda, T.6
-
19
-
-
0037370498
-
A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference
-
DOI 10.1038/ng1117
-
Rubinson DA, Dillon CP, Kwiatkowski AV, Sievers C, Yang L, Kopinja J, Rooney DL, Zhang M, Ihrig MM, McManus MT, Gertler FB, Scott ML, Van Parijs L. A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference. Nat Genet 2003; 33: 401-406 (Pubitemid 36278858)
-
(2003)
Nature Genetics
, vol.33
, Issue.3
, pp. 401-406
-
-
Rubinson, D.A.1
Dillon, C.P.2
Kwiatkowski, A.V.3
Sievers, C.4
Yang, L.5
Kopinja, J.6
Zhang, M.7
McManus, M.T.8
Gertler, F.B.9
Scott, M.L.10
Van Parijs, L.11
-
20
-
-
27144433826
-
Methylation silencing of SOCS-3 promotes cell growth and migration by enhancing JAK/STAT and FAK signalings in human hepatocellular carcinoma
-
DOI 10.1038/sj.onc.1208788, PII 1208788
-
Niwa Y, Kanda H, Shikauchi Y, Saiura A, Matsubara K, Kitagawa T, Yamamoto J, Kubo T, Yoshikawa H. Methylation silencing of SOCS-3 promotes cell growth and migration by enhancing JAK/STAT and FAK signalings in human hepatocellular carcinoma. Oncogene 2005; 24: 6406-6417 (Pubitemid 41486474)
-
(2005)
Oncogene
, vol.24
, Issue.42
, pp. 6406-6417
-
-
Niwa, Y.1
Kanda, H.2
Shikauchi, Y.3
Saiura, A.4
Matsubara, K.5
Kitagawa, T.6
Yamamoto, J.7
Kubo, T.8
Yoshikawa, H.9
-
21
-
-
34249902824
-
RNA interference-mediated signal transducers and activators of transcription 3 gene silencing inhibits invasion and metastasis of human pancreatic cancer cells
-
DOI 10.1111/j.1349-7006.2007.00485.x
-
Qiu Z, Huang C, Sun J, Qiu W, Zhang J, Li H, Jiang T, Huang K, Cao J. RNA interference-mediated signal transducers and activators of transcription 3 gene silencing inhibits invasion and metastasis of human pancreatic cancer cells. Cancer Sci 2007; 98: 1099-1106 (Pubitemid 46865397)
-
(2007)
Cancer Science
, vol.98
, Issue.7
, pp. 1099-1106
-
-
Qiu, Z.1
Huang, C.2
Sun, J.3
Qiu, W.4
Zhang, J.5
Li, H.6
Jiang, T.7
Huang, K.8
Cao, J.9
-
22
-
-
0037062951
-
RNA interference
-
Hannon GJ. RNA interference. Nature 2002; 418: 244-251
-
(2002)
Nature
, vol.418
, pp. 244-251
-
-
Hannon, G.J.1
-
23
-
-
33644840901
-
siRNA - Getting the message out
-
Lee SH, Sinko PJ. siRNA - getting the message out. Eur J Pharm Sci 2006; 27: 401-410
-
(2006)
Eur J Pharm Sci
, vol.27
, pp. 401-410
-
-
Lee, S.H.1
Sinko, P.J.2
-
24
-
-
32644452086
-
RNA interference in cancer
-
Gartel AL, Kandel ES. RNA interference in cancer. Biomol Eng 2006; 23: 17-34
-
(2006)
Biomol Eng
, vol.23
, pp. 17-34
-
-
Gartel, A.L.1
Kandel, E.S.2
-
25
-
-
25144495252
-
Lentiviral vector delivery of siRNA and shRNA encoding genes into cultured and primary hematopoietic cells
-
Li M, Rossi JJ. Lentiviral vector delivery of siRNA and shRNA encoding genes into cultured and primary hematopoietic cells. Methods Mol Biol 2005; 309: 261-272
-
(2005)
Methods Mol Biol
, vol.309
, pp. 261-272
-
-
Li, M.1
Rossi, J.J.2
-
26
-
-
13844281898
-
Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy
-
DOI 10.1038/nbt1051
-
Kim DH, Behlke MA, Rose SD, Chang MS, Choi S, Rossi JJ. Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy. Nat Biotechnol 2005; 23: 222-226 (Pubitemid 40255333)
-
(2005)
Nature Biotechnology
, vol.23
, Issue.2
, pp. 222-226
-
-
Kim, D.-H.1
Behlke, M.A.2
Rose, S.D.3
Chang, M.-S.4
Choi, S.5
Rossi, J.J.6
-
27
-
-
27544476971
-
The role of IL-6 and STAT3 in inflammation and cancer
-
Hodge DR, Hurt EM, Farrar WL. The role of IL-6 and STAT3 in inflammation and cancer. Eur J Cancer 2005; 41: 2502-2512
-
(2005)
Eur J Cancer
, vol.41
, pp. 2502-2512
-
-
Hodge, D.R.1
Hurt, E.M.2
Farrar, W.L.3
-
28
-
-
21344435775
-
Mechanisms of disease: Insights into the emerging role of signal transducers and activators of transcription in cancer
-
DOI 10.1038/ncponc0195
-
Haura EB, Turkson J, Jove R. Mechanisms of disease: Insights into the emerging role of signal transducers and activators of transcription in cancer. Nat Clin Pract Oncol 2005; 2: 315-324 (Pubitemid 40903176)
-
(2005)
Nature Clinical Practice Oncology
, vol.2
, Issue.6
, pp. 315-324
-
-
Haura, E.B.1
Turkson, J.2
Jove, R.3
-
29
-
-
0042825695
-
Activated signal transducer and activator of transcription 3 (STAT3) supports the malignant phenotype of human pancreatic cancer
-
DOI 10.1016/S0016-5085(03)01064-3
-
Scholz A, Heinze S, Detjen KM, Peters M, Welzel M, Hauff P, Schirner M, Wiedenmann B, Rosewicz S. Activated signal transducer and activator of transcription 3 (STAT3) supports the malignant phenotype of human pancreatic cancer. Gastroenterology 2003; 125: 891-905 (Pubitemid 37070705)
-
(2003)
Gastroenterology
, vol.125
, Issue.3
, pp. 891-905
-
-
Scholz, A.1
Heinze, S.2
Detjen, K.M.3
Peters, M.4
Welzel, M.5
Hauff, P.6
Schirner, M.7
Wiedenmann, B.8
Rosewicz, S.9
-
30
-
-
0142122338
-
Blockade of constitutively activated Janus kinase/signal transducer and activator of transcription-3 pathway inhibits growth of human pancreatic cancer
-
DOI 10.1016/S0304-3835(03)00482-8
-
Toyonaga T, Nakano K, Nagano M, Zhao G, Yamaguchi K, Kuroki S, Eguchi T, Chijiiwa K, Tsuneyoshi M, Tanaka M. Blockade of constitutively activated Janus kinase/signal transducer and activator of transcription-3 pathway inhibits growth of human pancreatic cancer. Cancer Lett 2003; 201: 107-116 (Pubitemid 37298003)
-
(2003)
Cancer Letters
, vol.201
, Issue.1
, pp. 107-116
-
-
Toyonaga, T.1
Nakano, K.2
Nagano, M.3
Zhao, G.4
Yamaguchi, K.5
Kuroki, S.6
Eguchi, T.7
Chijiiwa, K.8
Tsuneyoshi, M.9
Tanaka, M.10
-
31
-
-
2442707740
-
Disruption of STAT3 signaling leads to tumor cell invasion through alterations of homotypic cell-cell adhesion complexes
-
DOI 10.1038/sj.onc.1207437
-
Rivat C, De Wever O, Bruyneel E, Mareel M, Gespach C, Attoub S. Disruption of STAT3 signaling leads to tumor cell invasion through alterations of homotypic cell-cell adhesion complexes. Oncogene 2004; 23: 3317-3327 (Pubitemid 38669821)
-
(2004)
Oncogene
, vol.23
, Issue.19
, pp. 3317-3327
-
-
Rivat, C.1
De Wever, O.2
Bruyneel, E.3
Mareel, M.4
Gespach, C.5
Attoub, S.6
-
32
-
-
0033119833
-
Tumor-derived expression of vascular endothelial growth factor is a critical factor in tumor expansion and vascular function
-
Grunstein J, Roberts WG, Mathieu-Costello O, Hanahan D, Johnson RS. Tumor-derived expression of vascular endothelial growth factor is a critical factor in tumor expansion and vascular function. Cancer Res 1999; 59: 1592-1598 (Pubitemid 29160131)
-
(1999)
Cancer Research
, vol.59
, Issue.7
, pp. 1592-1598
-
-
Grunstein, J.1
Roberts, W.G.2
Mathieu-Costello, O.3
Hanahan, D.4
Johnson, R.S.5
-
33
-
-
0037461934
-
Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis
-
DOI 10.1038/sj.onc.1206122
-
Wei D, Le X, Zheng L, Wang L, Frey JA, Gao AC, Peng Z, Huang S, Xiong HQ, Abbruzzese JL, Xie K. Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis. Oncogene 2003; 22: 319-329 (Pubitemid 36194328)
-
(2003)
Oncogene
, vol.22
, Issue.3
, pp. 319-329
-
-
Wei, D.1
Le, X.2
Zheng, L.3
Wang, L.4
Frey, J.A.5
Gao, A.C.6
Peng, Z.7
Huang, S.8
Xiong, H.Q.9
Abbruzzese, J.L.10
Xie, K.11
-
34
-
-
0036334059
-
Matrix metalloproteinases and their role in pancreatic cancer: A review of preclinical studies and clinical trials
-
DOI 10.1245/aso.2002.9.7.668
-
Bloomston M, Zervos EE, Rosemurgy AS 2nd. Matrix metalloproteinases and their role in pancreatic cancer: a review of preclinical studies and clinical trials. Ann Surg Oncol 2002; 9: 668-674 (Pubitemid 34857984)
-
(2002)
Annals of Surgical Oncology
, vol.9
, Issue.7
, pp. 668-674
-
-
Bloomston, M.1
Zervos, E.E.2
Rosemurgy II, A.S.3
-
35
-
-
0036267895
-
Comparison of matrix metalloproteinase expression between primary tumors with or without liver metastasis in pancreatic and colorectal carcinomas
-
DOI 10.1002/jso.10106
-
Matsuyama Y, Takao S, Aikou T. Comparison of matrix metalloproteinase expression between primary tumors with or without liver metastasis in pancreatic and colorectal carcinomas. J Surg Oncol 2002; 80: 105-110 (Pubitemid 34569178)
-
(2002)
Journal of Surgical Oncology
, vol.80
, Issue.2
, pp. 105-110
-
-
Matsuyama, Y.1
Takao, S.2
Aikou, T.3
-
36
-
-
21444444445
-
Involvement of matrix metalloproteinase-7 in invasion-metastasis through induction of cell dissociation in pancreatic cancer
-
Tan X, Egami H, Ishikawa S, Sugita H, Kamohara H, Nakagawa M, Nozawa F, Abe M, Ogawa M. Involvement of matrix metalloproteinase-7 in invasion-metastasis through induction of cell dissociation in pancreatic cancer. Int J Oncol 2005; 26: 1283-1289
-
(2005)
Int J Oncol
, vol.26
, pp. 1283-1289
-
-
Tan, X.1
Egami, H.2
Ishikawa, S.3
Sugita, H.4
Kamohara, H.5
Nakagawa, M.6
Nozawa, F.7
Abe, M.8
Ogawa, M.9
-
37
-
-
33645532055
-
Activation of stat3 in human melanoma promotes brain metastasis
-
Xie TX, Huang FJ, Aldape KD, Kang SH, Liu M, Gershenwald JE, Xie K, Sawaya R, Huang S. Activation of stat3 in human melanoma promotes brain metastasis. Cancer Res 2006; 66: 3188-3196
-
(2006)
Cancer Res
, vol.66
, pp. 3188-3196
-
-
Xie, T.X.1
Huang, F.J.2
Aldape, K.D.3
Kang, S.H.4
Liu, M.5
Gershenwald, J.E.6
Xie, K.7
Sawaya, R.8
Huang, S.9
|