-
1
-
-
84880511470
-
Chronic kidney disease: Global dimension and perspectives
-
V. Jha Chronic kidney disease: global dimension and perspectives Lancet 382 2013 260 272
-
(2013)
Lancet
, vol.382
, pp. 260-272
-
-
Jha, V.1
-
2
-
-
79959936188
-
National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: Systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2.7 million participants
-
G. Danaei National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2.7 million participants Lancet 378 2011 31 40
-
(2011)
Lancet
, vol.378
, pp. 31-40
-
-
Danaei, G.1
-
3
-
-
33646771273
-
Prevalence and risk factors for microalbuminuria in a referred cohort of type II diabetic patients: A global perspective
-
H.H. Parving Prevalence and risk factors for microalbuminuria in a referred cohort of type II diabetic patients: a global perspective Kidney Int. 69 2006 2057 2063
-
(2006)
Kidney Int.
, vol.69
, pp. 2057-2063
-
-
Parving, H.H.1
-
4
-
-
76749103329
-
Diabetic kidney disease: Act now or pay later
-
R.C. Atkins, and P. Zimmet Diabetic kidney disease: act now or pay later Kidney Int. 77 2010 375 377
-
(2010)
Kidney Int.
, vol.77
, pp. 375-377
-
-
Atkins, R.C.1
Zimmet, P.2
-
5
-
-
84865223234
-
Diabetes: Treating diabetic nephropathy - Still an unresolved issue
-
M.E. Cooper Diabetes: treating diabetic nephropathy - still an unresolved issue Nat. Rev. Endocrinol. 8 2012 515 516
-
(2012)
Nat. Rev. Endocrinol.
, vol.8
, pp. 515-516
-
-
Cooper, M.E.1
-
6
-
-
0037349373
-
Hyperfiltration and glomerulosclerosis
-
T.H. Hostetter Hyperfiltration and glomerulosclerosis Semin. Nephrol. 23 2003 194 199
-
(2003)
Semin. Nephrol.
, vol.23
, pp. 194-199
-
-
Hostetter, T.H.1
-
7
-
-
79952186370
-
Oxidative stress in early diabetic nephropathy: Fueling the fire
-
D.K. Singh Oxidative stress in early diabetic nephropathy: fueling the fire Nat. Rev. Endocrinol. 7 2011 176 184
-
(2011)
Nat. Rev. Endocrinol.
, vol.7
, pp. 176-184
-
-
Singh, D.K.1
-
8
-
-
79957874666
-
Inflammatory molecules and pathways in the pathogenesis of diabetic nephropathy
-
J.F. Navarro-Gonzalez Inflammatory molecules and pathways in the pathogenesis of diabetic nephropathy Nat. Rev. Nephrol. 7 2011 327 340
-
(2011)
Nat. Rev. Nephrol.
, vol.7
, pp. 327-340
-
-
Navarro-Gonzalez, J.F.1
-
9
-
-
28844504752
-
Effect of inhibitors of the renin-angiotensin system and other antihypertensive drugs on renal outcomes: Systematic review and meta-analysis
-
J.P. Casas Effect of inhibitors of the renin-angiotensin system and other antihypertensive drugs on renal outcomes: systematic review and meta-analysis Lancet 366 2005 2026 2033
-
(2005)
Lancet
, vol.366
, pp. 2026-2033
-
-
Casas, J.P.1
-
10
-
-
34247640280
-
Combination therapy with an ACE inhibitor and an angiotensin receptor blocker for diabetic nephropathy: A meta-analysis
-
D.L. Jennings Combination therapy with an ACE inhibitor and an angiotensin receptor blocker for diabetic nephropathy: a meta-analysis Diabet. Med. 24 2007 486 493
-
(2007)
Diabet. Med.
, vol.24
, pp. 486-493
-
-
Jennings, D.L.1
-
11
-
-
79953759095
-
Genetic associations in diabetic nephropathy
-
A.L. Mooyaart Genetic associations in diabetic nephropathy Clin. Exp. Nephrol. 54 2013 544 553
-
(2013)
Clin. Exp. Nephrol.
, vol.54
, pp. 544-553
-
-
Mooyaart, A.L.1
-
12
-
-
3242715114
-
Reactive oxygen species: Metabolism, oxidative stress, and signal transduction
-
K. Apel, and H. Hirt Reactive oxygen species: metabolism, oxidative stress, and signal transduction Annu. Rev. Plant Biol. 55 2004 373 399
-
(2004)
Annu. Rev. Plant Biol.
, vol.55
, pp. 373-399
-
-
Apel, K.1
Hirt, H.2
-
13
-
-
34547788748
-
Suppressing renal NADPH oxidase to treat diabetic nephropathy
-
A. Tojo Suppressing renal NADPH oxidase to treat diabetic nephropathy Expert Opin. Ther. Targets 11 2007 1011 1018
-
(2007)
Expert Opin. Ther. Targets
, vol.11
, pp. 1011-1018
-
-
Tojo, A.1
-
14
-
-
34547487924
-
The role of protein kinase C activation in diabetic nephropathy
-
H. Noh, and G.L. King The role of protein kinase C activation in diabetic nephropathy Kidney Int. 72 2007 S49 S53
-
(2007)
Kidney Int.
, vol.72
, pp. S49-S53
-
-
Noh, H.1
King, G.L.2
-
15
-
-
0035856980
-
Biochemistry and molecular cell biology of diabetic complications
-
M. Brownlee Biochemistry and molecular cell biology of diabetic complications Nature 414 2001 813 820
-
(2001)
Nature
, vol.414
, pp. 813-820
-
-
Brownlee, M.1
-
16
-
-
0034643340
-
Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage
-
T. Nishikawa Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage Nature 404 2000 787 790
-
(2000)
Nature
, vol.404
, pp. 787-790
-
-
Nishikawa, T.1
-
17
-
-
84872041647
-
Inflammation and the pathogenesis of diabetic nephropathy
-
J. Wada, and H. Makino Inflammation and the pathogenesis of diabetic nephropathy Clin. Sci. 124 2013 139 152
-
(2013)
Clin. Sci.
, vol.124
, pp. 139-152
-
-
Wada, J.1
Makino, H.2
-
18
-
-
34249091068
-
Inflammatory cells in renal injury and repair
-
D. Ferenbach Inflammatory cells in renal injury and repair Semin. Nephrol. 27 2007 250 259
-
(2007)
Semin. Nephrol.
, vol.27
, pp. 250-259
-
-
Ferenbach, D.1
-
19
-
-
82355190219
-
Cellular and molecular mechanisms of renal fibrosis
-
Y. Liu Cellular and molecular mechanisms of renal fibrosis Nat. Rev. Nephrol. 7 2011 684 696
-
(2011)
Nat. Rev. Nephrol.
, vol.7
, pp. 684-696
-
-
Liu, Y.1
-
20
-
-
80052317444
-
The role of TGF-β and epithelial-to-mesenchymal transition in diabetic nephropathy
-
C.E. Hills, and P.E. Squires The role of TGF-β and epithelial-to-mesenchymal transition in diabetic nephropathy Cytokine Growth Factor Rev. 22 2011 131 139
-
(2011)
Cytokine Growth Factor Rev.
, vol.22
, pp. 131-139
-
-
Hills, C.E.1
Squires, P.E.2
-
21
-
-
84902472921
-
The role of transforming growth factor-beta in diabetic nephropathy
-
G.K. Braga The role of transforming growth factor-beta in diabetic nephropathy Int. J. Med. Genet. 2014 2014 1 6
-
(2014)
Int. J. Med. Genet.
, vol.2014
, pp. 1-6
-
-
Braga, G.K.1
-
22
-
-
0033534573
-
Alternatively spliced variant of Smad2 lacking exon 3: Comparison with wild-type Smad2 and Smad3
-
K. Yagi Alternatively spliced variant of Smad2 lacking exon 3: comparison with wild-type Smad2 and Smad3 J. Biol. Chem. 274 1999 703 709
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 703-709
-
-
Yagi, K.1
-
23
-
-
40049099699
-
Oral administration of GW788388, an inhibitor of TGF-β type i and II receptor kinases, decreases renal fibrosis
-
M. Petersen Oral administration of GW788388, an inhibitor of TGF-β type I and II receptor kinases, decreases renal fibrosis Kidney Int. 73 2007 705 715
-
(2007)
Kidney Int.
, vol.73
, pp. 705-715
-
-
Petersen, M.1
-
24
-
-
33644912981
-
Independent and additive impact of blood pressure control and angiotensin II receptor blockade on renal outcomes in the irbesartan diabetic nephropathy trial: Clinical implications and limitations
-
M.A. Pohl Independent and additive impact of blood pressure control and angiotensin II receptor blockade on renal outcomes in the irbesartan diabetic nephropathy trial: clinical implications and limitations J. Am. Soc. Nephrol. 16 2005 3027 3037
-
(2005)
J. Am. Soc. Nephrol.
, vol.16
, pp. 3027-3037
-
-
Pohl, M.A.1
-
25
-
-
77951735232
-
Effects of intensive blood-pressure control in type 2 diabetes mellitus
-
W.C. Cushman Effects of intensive blood-pressure control in type 2 diabetes mellitus N. Engl. J. Med. 362 2010 1575
-
(2010)
N. Engl. J. Med.
, vol.362
, pp. 1575
-
-
Cushman, W.C.1
-
26
-
-
0036145348
-
Oxidative stress and nitric oxide synthase in rat diabetic nephropathy: Effects of ACEI and ARB
-
M.L. Onozato Oxidative stress and nitric oxide synthase in rat diabetic nephropathy: effects of ACEI and ARB Kidney Int. 61 2002 186 194
-
(2002)
Kidney Int.
, vol.61
, pp. 186-194
-
-
Onozato, M.L.1
-
27
-
-
14844363404
-
Aliskiren, a novel orally effective renin inhibitor, provides dose-dependent antihypertensive efficacy and placebo-like tolerability in hypertensive patients
-
A.H. Gradman Aliskiren, a novel orally effective renin inhibitor, provides dose-dependent antihypertensive efficacy and placebo-like tolerability in hypertensive patients Circulation 111 2005 1012 1018
-
(2005)
Circulation
, vol.111
, pp. 1012-1018
-
-
Gradman, A.H.1
-
28
-
-
33749985149
-
Oral renin inhibitors
-
J.A. Staessen Oral renin inhibitors Lancet 368 2006 1449 1456
-
(2006)
Lancet
, vol.368
, pp. 1449-1456
-
-
Staessen, J.A.1
-
30
-
-
77954383099
-
Aliskiren enhances protective effects of valsartan against type 2 diabetic nephropathy in mice
-
Y.-F. Dong Aliskiren enhances protective effects of valsartan against type 2 diabetic nephropathy in mice J. Hypertens. 28 2010 1554 1565
-
(2010)
J. Hypertens.
, vol.28
, pp. 1554-1565
-
-
Dong, Y.-F.1
-
31
-
-
84865642129
-
Baseline characteristics in the Aliskiren Trial in Type 2 Diabetes Using Cardio-Renal Endpoints (ALTITUDE)
-
H.H. Parving Baseline characteristics in the Aliskiren Trial in Type 2 Diabetes Using Cardio-Renal Endpoints (ALTITUDE) J. Renin Angiotensin Aldosterone Syst. 13 2012 387 393
-
(2012)
J. Renin Angiotensin Aldosterone Syst.
, vol.13
, pp. 387-393
-
-
Parving, H.H.1
-
32
-
-
84859084617
-
Aliskiren, ALTITUDE, and the implications for ATMOSPHERE
-
J.J. McMurray Aliskiren, ALTITUDE, and the implications for ATMOSPHERE Eur. J. Heart Fail. 14 2012 341 343
-
(2012)
Eur. J. Heart Fail.
, vol.14
, pp. 341-343
-
-
McMurray, J.J.1
-
33
-
-
77955585592
-
Effect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: An analysis of the ACCORD randomised trial
-
F. Ismail-Beigi Effect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: an analysis of the ACCORD randomised trial Lancet 376 2010 419 430
-
(2010)
Lancet
, vol.376
, pp. 419-430
-
-
Ismail-Beigi, F.1
-
34
-
-
84855245399
-
Intensive diabetes therapy and glomerular filtration rate in type 1 diabetes
-
DCCT/EDIC Research Group Intensive diabetes therapy and glomerular filtration rate in type 1 diabetes N. Engl. J. Med. 2011 2011 2366 2376
-
(2011)
N. Engl. J. Med.
, vol.2011
, pp. 2366-2376
-
-
Research Group, D.1
-
35
-
-
79251604529
-
Sitagliptin reduces albuminuria in patients with type 2 diabetes
-
S. Hattori Sitagliptin reduces albuminuria in patients with type 2 diabetes Endocr. J. 58 2010 69 73
-
(2010)
Endocr. J.
, vol.58
, pp. 69-73
-
-
Hattori, S.1
-
36
-
-
84890476805
-
Linagliptin lowers albuminuria on top of recommended standard treatment in patients with type 2 diabetes and renal dysfunction
-
P.-H. Groop Linagliptin lowers albuminuria on top of recommended standard treatment in patients with type 2 diabetes and renal dysfunction Diabetes Care 36 2013 3460 3468
-
(2013)
Diabetes Care
, vol.36
, pp. 3460-3468
-
-
Groop, P.-H.1
-
37
-
-
33846443625
-
Podocyte as the target for aldosterone roles of oxidative stress and Sgk1
-
S. Shibata Podocyte as the target for aldosterone roles of oxidative stress and Sgk1 Hypertension 49 2007 355 364
-
(2007)
Hypertension
, vol.49
, pp. 355-364
-
-
Shibata, S.1
-
38
-
-
31744433843
-
Cardioprotective mechanisms of spironolactone associated with the angiotensin-converting enzyme/epidermal growth factor receptor/extracellular signal-regulated kinases, NAD (P) H oxidase/lectin-like oxidized low-density lipoprotein receptor-1, and Rho-kinase pathways in aldosterone/salt-induced hypertensive rats
-
S. Nakano Cardioprotective mechanisms of spironolactone associated with the angiotensin-converting enzyme/epidermal growth factor receptor/extracellular signal-regulated kinases, NAD (P) H oxidase/lectin-like oxidized low-density lipoprotein receptor-1, and Rho-kinase pathways in aldosterone/salt-induced hypertensive rats Hypertens. Res. 28 2005 925 936
-
(2005)
Hypertens. Res.
, vol.28
, pp. 925-936
-
-
Nakano, S.1
-
39
-
-
77955888805
-
Discovery of (3S,3aR)-2-(3-chloro-4-cyanophenyl)-3-cyclopentyl-3,3a, 4,5-tetrahydro-2H-benzo[g] indazole-7-carboxylic acid (PF-3882845), an orally efficacious mineralocorticoid receptor (MR) antagonist for hypertension and nephropathy
-
M.J. Meyers Discovery of (3S,3aR)-2-(3-chloro-4-cyanophenyl)-3-cyclopentyl-3,3a, 4,5-tetrahydro-2H-benzo[g] indazole-7-carboxylic acid (PF-3882845), an orally efficacious mineralocorticoid receptor (MR) antagonist for hypertension and nephropathy J. Med. Chem. 53 2010 5979 6002
-
(2010)
J. Med. Chem.
, vol.53
, pp. 5979-6002
-
-
Meyers, M.J.1
-
40
-
-
84866859500
-
Mineralocorticoid receptor antagonists for the treatment of hypertension and diabetic nephropathy
-
D.W. Piotrowski Mineralocorticoid receptor antagonists for the treatment of hypertension and diabetic nephropathy J. Med. Chem. 55 2012 7957 7966
-
(2012)
J. Med. Chem.
, vol.55
, pp. 7957-7966
-
-
Piotrowski, D.W.1
-
41
-
-
79960563100
-
Improving neuropathy scores in type 2 diabetic patients using micronutrients supplementation
-
M.S. Farvid Improving neuropathy scores in type 2 diabetic patients using micronutrients supplementation Diabetes Res. Clin. Pract. 93 2011 86 94
-
(2011)
Diabetes Res. Clin. Pract.
, vol.93
, pp. 86-94
-
-
Farvid, M.S.1
-
42
-
-
25644452089
-
Comparison of the effects of vitamins and/or mineral supplementation on glomerular and tubular dysfunction in type 2 diabetes
-
M.S. Farvid Comparison of the effects of vitamins and/or mineral supplementation on glomerular and tubular dysfunction in type 2 diabetes Diabetes Care 28 2005 2458 2464
-
(2005)
Diabetes Care
, vol.28
, pp. 2458-2464
-
-
Farvid, M.S.1
-
43
-
-
33846611038
-
Double-edged action of SOD mimetic in diabetic nephropathy
-
K. Asaba Double-edged action of SOD mimetic in diabetic nephropathy J. Cardiovasc. Pharmacol. 49 2007 13 19
-
(2007)
J. Cardiovasc. Pharmacol.
, vol.49
, pp. 13-19
-
-
Asaba, K.1
-
44
-
-
79952998056
-
Antioxidants in the treatment of diabetes
-
S. Golbidi Antioxidants in the treatment of diabetes Curr. Diabetes Rev. 7 2011 106 125
-
(2011)
Curr. Diabetes Rev.
, vol.7
, pp. 106-125
-
-
Golbidi, S.1
-
45
-
-
33847378451
-
Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: Systematic review and meta-analysis
-
G. Bjelakovic Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis JAMA 297 2007 842 857
-
(2007)
JAMA
, vol.297
, pp. 842-857
-
-
Bjelakovic, G.1
-
46
-
-
19944427642
-
Meta-analysis: High-dosage vitamin e supplementation may increase all-cause mortality
-
E.R. Miller 3rd Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality Ann. Intern. Med. 142 2005 37 46
-
(2005)
Ann. Intern. Med.
, vol.142
, pp. 37-46
-
-
Miller, E.R.1
-
47
-
-
53549103020
-
Molecular detection of exercise-induced free radicals following ascorbate prophylaxis in type 1 diabetes mellitus: A randomised controlled trial
-
G.W. Davison Molecular detection of exercise-induced free radicals following ascorbate prophylaxis in type 1 diabetes mellitus: a randomised controlled trial Diabetologia 51 2008 2049 2059
-
(2008)
Diabetologia
, vol.51
, pp. 2049-2059
-
-
Davison, G.W.1
-
48
-
-
80054054044
-
Aldose reductase: New insights for an old enzyme
-
K.V. Ramana Aldose reductase: new insights for an old enzyme Biomol. Concepts 2 2011 103 114
-
(2011)
Biomol. Concepts
, vol.2
, pp. 103-114
-
-
Ramana, K.V.1
-
49
-
-
0042867413
-
Contribution of polyol pathway to diabetes-induced oxidative stress
-
S.S.M. Chung Contribution of polyol pathway to diabetes-induced oxidative stress J. Am. Soc. Nephrol. 14 2003 233 236
-
(2003)
J. Am. Soc. Nephrol.
, vol.14
, pp. 233-236
-
-
Chung, S.S.M.1
-
50
-
-
79954628216
-
Genetic deficiency of aldose reductase counteracts the development of diabetic nephropathy in C57BL/6 mice
-
H. Liu Genetic deficiency of aldose reductase counteracts the development of diabetic nephropathy in C57BL/6 mice Diabetologia 54 2011 1242 1251
-
(2011)
Diabetologia
, vol.54
, pp. 1242-1251
-
-
Liu, H.1
-
51
-
-
26444477394
-
A novel series of non-carboxylic acid, non-hydantoin inhibitors of aldose reductase with potent oral activity in diabetic rat models: 6-(5-chloro-3-methylbenzofuran-2-sulfonyl)-2 H-pyridazin-3-one and congeners
-
B.L. Mylari A novel series of non-carboxylic acid, non-hydantoin inhibitors of aldose reductase with potent oral activity in diabetic rat models: 6-(5-chloro-3-methylbenzofuran-2-sulfonyl)-2 H-pyridazin-3-one and congeners J. Med. Chem. 48 2005 6326 6339
-
(2005)
J. Med. Chem.
, vol.48
, pp. 6326-6339
-
-
Mylari, B.L.1
-
52
-
-
0000930578
-
Isolation and properties of lens aldose reductase
-
S. Hayman, and J.H. Kinoshita Isolation and properties of lens aldose reductase J. Biol. Chem. 240 1965 877 882
-
(1965)
J. Biol. Chem.
, vol.240
, pp. 877-882
-
-
Hayman, S.1
Kinoshita, J.H.2
-
53
-
-
0016243140
-
Mechanisms initiating cataract formation proctor lecture
-
J.H. Kinoshita Mechanisms initiating cataract formation proctor lecture Invest. Ophthalmol. Vis. Sci. 13 1974 713 724
-
(1974)
Invest. Ophthalmol. Vis. Sci.
, vol.13
, pp. 713-724
-
-
Kinoshita, J.H.1
-
55
-
-
0015887637
-
Polyol accumulation in galactosemic and diabetic rats: Control by an aldose reductase inhibitor
-
D. Dvornik Polyol accumulation in galactosemic and diabetic rats: control by an aldose reductase inhibitor Science 182 1973 1146 1148
-
(1973)
Science
, vol.182
, pp. 1146-1148
-
-
Dvornik, D.1
-
56
-
-
42949097094
-
Epalrestat: An aldose reductase inhibitor for the treatment of diabetic neuropathy
-
M.A. Ramirez, and N.L. Borja Epalrestat: an aldose reductase inhibitor for the treatment of diabetic neuropathy Pharmacother: J. Hum. Pharmacol. Drug Ther. 28 2008 646 655
-
(2008)
Pharmacother: J. Hum. Pharmacol. Drug Ther.
, vol.28
, pp. 646-655
-
-
Ramirez, M.A.1
Borja, N.L.2
-
57
-
-
0027943786
-
The effect of an aldose reductase inhibitor (epalrestat) on diabetic nephropathy in rats
-
I. Itagaki The effect of an aldose reductase inhibitor (epalrestat) on diabetic nephropathy in rats Diabetes Res. Clin. Pract. 25 1994 147 154
-
(1994)
Diabetes Res. Clin. Pract.
, vol.25
, pp. 147-154
-
-
Itagaki, I.1
-
58
-
-
0030015170
-
Zopolrestat prevention of proteinuria, albuminuria and cataractogenesis in diabetes mellitus
-
A. Beyer-Mears Zopolrestat prevention of proteinuria, albuminuria and cataractogenesis in diabetes mellitus Pharmacology 52 1996 292 302
-
(1996)
Pharmacology
, vol.52
, pp. 292-302
-
-
Beyer-Mears, A.1
-
59
-
-
77955652860
-
Role of aldose reductase in the high glucose induced expression of fibronectin in human mesangial cells
-
P. Huang Role of aldose reductase in the high glucose induced expression of fibronectin in human mesangial cells Mol. Biol. Rep. 37 2010 3017 3021
-
(2010)
Mol. Biol. Rep.
, vol.37
, pp. 3017-3021
-
-
Huang, P.1
-
60
-
-
0030338728
-
Prevention of early glomerulopathy with tolrestat in the streptozotocin-induced diabetic rat
-
S.M. Donnelly Prevention of early glomerulopathy with tolrestat in the streptozotocin-induced diabetic rat Biochem. Cell Biol. 74 1996 355 362
-
(1996)
Biochem. Cell Biol.
, vol.74
, pp. 355-362
-
-
Donnelly, S.M.1
-
61
-
-
0033778502
-
The effect of sorbinil, an aldose reductase inhibitor, on aortic function in control and streptozotocin-induced diabetic rats
-
D.J. Sellers, and R. Chess-Williams The effect of sorbinil, an aldose reductase inhibitor, on aortic function in control and streptozotocin-induced diabetic rats J. Auton. Pharmacol. 20 2000 15 22
-
(2000)
J. Auton. Pharmacol.
, vol.20
, pp. 15-22
-
-
Sellers, D.J.1
Chess-Williams, R.2
-
62
-
-
29144515759
-
Stereospecific recognition of a spirosuccinimide type aldose reductase inhibitor (AS-3201) by plasma proteins: A significant role of specific binding by serum albumin in the improved potency and stability
-
M. Kurono Stereospecific recognition of a spirosuccinimide type aldose reductase inhibitor (AS-3201) by plasma proteins: a significant role of specific binding by serum albumin in the improved potency and stability Biochem. Pharmacol. 71 2006 338 353
-
(2006)
Biochem. Pharmacol.
, vol.71
, pp. 338-353
-
-
Kurono, M.1
-
63
-
-
33646068113
-
Aldose reductase inhibition counteracts nitrosative stress and poly(ADP-ribose) polymerase activation in diabetic rat kidney and high-glucose-exposed human mesangial cells
-
V.R. Drel Aldose reductase inhibition counteracts nitrosative stress and poly(ADP-ribose) polymerase activation in diabetic rat kidney and high-glucose-exposed human mesangial cells Free Radic. Biol. Med. 40 2006 1454 1465
-
(2006)
Free Radic. Biol. Med.
, vol.40
, pp. 1454-1465
-
-
Drel, V.R.1
-
64
-
-
84867752191
-
Novel aldose reductase inhibitors: A patent survey (2006-present)
-
M. Chatzopoulou Novel aldose reductase inhibitors: a patent survey (2006-present) Expert Opin. Ther. Pat. 22 2012 1303 1323
-
(2012)
Expert Opin. Ther. Pat.
, vol.22
, pp. 1303-1323
-
-
Chatzopoulou, M.1
-
65
-
-
84861230090
-
Novel insights into the structural requirements for the design of selective and specific aldose reductase inhibitors
-
H. Kumar Novel insights into the structural requirements for the design of selective and specific aldose reductase inhibitors J. Mol. Model 18 2012 1791 1799
-
(2012)
J. Mol. Model
, vol.18
, pp. 1791-1799
-
-
Kumar, H.1
-
66
-
-
84925412614
-
Oxidative stress and redox-signaling in renal cell cancer
-
J.R. Amato, InTech
-
K. Block Oxidative stress and redox-signaling in renal cell cancer J.R. Amato, Emerging Research and Treatments in Renal Cell Carcinoma 2012 InTech 137 166
-
(2012)
Emerging Research and Treatments in Renal Cell Carcinoma
, pp. 137-166
-
-
Block, K.1
-
67
-
-
0035897653
-
Homologs of gp91phox: Cloning and tissue expression of Nox3, Nox4, and Nox5
-
G. Cheng Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4, and Nox5 Gene 269 2001 131 140
-
(2001)
Gene
, vol.269
, pp. 131-140
-
-
Cheng, G.1
-
68
-
-
0034604797
-
The inhibition of flavoproteins by phenoxaiodonium, a new iodonium analogue
-
P. Moulton The inhibition of flavoproteins by phenoxaiodonium, a new iodonium analogue Eur. J. Pharmacol. 401 2000 115 120
-
(2000)
Eur. J. Pharmacol.
, vol.401
, pp. 115-120
-
-
Moulton, P.1
-
69
-
-
0027479814
-
Studies on the inhibitory mechanism of iodonium compounds with special reference to neutrophil NADPH oxidase
-
B. O'Donnell Studies on the inhibitory mechanism of iodonium compounds with special reference to neutrophil NADPH oxidase Biochem. J. 290 1993 41 49
-
(1993)
Biochem. J.
, vol.290
, pp. 41-49
-
-
O'Donnell, B.1
-
70
-
-
33846025045
-
The oxidation of apocynin catalyzed by myeloperoxidase: Proposal for NADPH oxidase inhibition
-
V.F. Ximenes The oxidation of apocynin catalyzed by myeloperoxidase: proposal for NADPH oxidase inhibition Arch. Biochem. Biophys. 457 2007 134 141
-
(2007)
Arch. Biochem. Biophys.
, vol.457
, pp. 134-141
-
-
Ximenes, V.F.1
-
71
-
-
84875625176
-
Apocynin: Chemical and biophysical properties of a NADPH oxidase inhibitor
-
M.S. Petronio Apocynin: chemical and biophysical properties of a NADPH oxidase inhibitor Molecules 18 2013 2821 2839
-
(2013)
Molecules
, vol.18
, pp. 2821-2839
-
-
Petronio, M.S.1
-
72
-
-
17744364508
-
Effects of NADPH oxidase inhibitor in diabetic nephropathy
-
K. Asaba Effects of NADPH oxidase inhibitor in diabetic nephropathy Kidney Int. 67 2005 1890 1898
-
(2005)
Kidney Int.
, vol.67
, pp. 1890-1898
-
-
Asaba, K.1
-
73
-
-
58249119832
-
Effects of NADPH oxidase inhibitor on diabetic nephropathy in OLETF rats: The role of reducing oxidative stress in its protective property
-
S.M. Nam Effects of NADPH oxidase inhibitor on diabetic nephropathy in OLETF rats: the role of reducing oxidative stress in its protective property Diabetes Res. Clin. Pract. 83 2009 176 182
-
(2009)
Diabetes Res. Clin. Pract.
, vol.83
, pp. 176-182
-
-
Nam, S.M.1
-
74
-
-
0025237558
-
Metabolic activation of natural phenols into selective oxidative burst agonists by activated human neutrophils
-
J.M. Simons Metabolic activation of natural phenols into selective oxidative burst agonists by activated human neutrophils Free Radic. Biol. Med. 8 1990 251 258
-
(1990)
Free Radic. Biol. Med.
, vol.8
, pp. 251-258
-
-
Simons, J.M.1
-
75
-
-
38549138327
-
Apocynin is not an inhibitor of vascular NADPH oxidases but an antioxidant
-
S. Heumuller Apocynin is not an inhibitor of vascular NADPH oxidases but an antioxidant Hypertension 51 2008 211 217
-
(2008)
Hypertension
, vol.51
, pp. 211-217
-
-
Heumuller, S.1
-
76
-
-
78649913769
-
Critical role of Nox4-based NADPH oxidase in glucose-induced oxidative stress in the kidney: Implications in type 2 diabetic nephropathy
-
M. Sedeek Critical role of Nox4-based NADPH oxidase in glucose-induced oxidative stress in the kidney: implications in type 2 diabetic nephropathy Am. J. Physiol. Renal. 299 2010 F1348 F1358
-
(2010)
Am. J. Physiol. Renal.
, vol.299
, pp. F1348-F1358
-
-
Sedeek, M.1
-
77
-
-
33646035513
-
Novel Nox inhibitor of oxLDL-induced reactive oxygen species formation in human endothelial cells
-
C. Stielow Novel Nox inhibitor of oxLDL-induced reactive oxygen species formation in human endothelial cells Biochem. Biophys. Res. Commun. 344 2006 200 205
-
(2006)
Biochem. Biophys. Res. Commun.
, vol.344
, pp. 200-205
-
-
Stielow, C.1
-
78
-
-
33745189788
-
Novel Nox inhibitor VAS2870 attenuates PDGF-dependent smooth muscle cell chemotaxis, but not proliferation
-
H. ten Freyhaus Novel Nox inhibitor VAS2870 attenuates PDGF-dependent smooth muscle cell chemotaxis, but not proliferation Cardiovasc. Res. 71 2006 331 341
-
(2006)
Cardiovasc. Res.
, vol.71
, pp. 331-341
-
-
Ten Freyhaus, H.1
-
79
-
-
84864360259
-
The NOX toolbox: Validating the role of NADPH oxidases in physiology and disease
-
S. Altenhofer The NOX toolbox: validating the role of NADPH oxidases in physiology and disease Cell. Mol. Life Sci. 69 2012 2327 2343
-
(2012)
Cell. Mol. Life Sci.
, vol.69
, pp. 2327-2343
-
-
Altenhofer, S.1
-
80
-
-
84871819023
-
Renoprotective effects of a novel Nox1/4 inhibitor in a mouse model of Type 2 diabetes
-
M. Sedeek Renoprotective effects of a novel Nox1/4 inhibitor in a mouse model of Type 2 diabetes Clin. Sci. (Lond.) 124 2013 191 202
-
(2013)
Clin. Sci. (Lond.)
, vol.124
, pp. 191-202
-
-
Sedeek, M.1
-
81
-
-
84897107588
-
Potential approaches to reverse or repair renal fibrosis
-
D. Tampe, and M. Zeisberg Potential approaches to reverse or repair renal fibrosis Nat. Rev. Nephrol. 10 2014 226 237
-
(2014)
Nat. Rev. Nephrol.
, vol.10
, pp. 226-237
-
-
Tampe, D.1
Zeisberg, M.2
-
82
-
-
34748876803
-
Relationship between Gilbert syndrome and prevalence of vascular complications in patients with diabetes
-
T. Inoguchi Relationship between Gilbert syndrome and prevalence of vascular complications in patients with diabetes JAMA 298 2007 1396 1400
-
(2007)
JAMA
, vol.298
, pp. 1396-1400
-
-
Inoguchi, T.1
-
83
-
-
77958086954
-
Bilirubin and biliverdin protect rodents against diabetic nephropathy by downregulating NAD (P) H oxidase
-
M. Fujii Bilirubin and biliverdin protect rodents against diabetic nephropathy by downregulating NAD (P) H oxidase Kidney Int. 78 2010 905 919
-
(2010)
Kidney Int.
, vol.78
, pp. 905-919
-
-
Fujii, M.1
-
84
-
-
84872421262
-
Phycocyanin and phycocyanobilin from Spirulina platensis protect against diabetic nephropathy by inhibiting oxidative stress
-
J. Zheng Phycocyanin and phycocyanobilin from Spirulina platensis protect against diabetic nephropathy by inhibiting oxidative stress Am. J. Physiol. Regul. Integr. Comp. Physiol. 304 2013 R110 R120
-
(2013)
Am. J. Physiol. Regul. Integr. Comp. Physiol.
, vol.304
, pp. R110-R120
-
-
Zheng, J.1
-
85
-
-
84876500601
-
Opportunity Nox: The future of NADPH oxidases as therapeutic targets in cardiovascular disease
-
J. Streeter Opportunity Nox: the future of NADPH oxidases as therapeutic targets in cardiovascular disease Cardiovasc. Ther. 31 2013 125 137
-
(2013)
Cardiovasc. Ther.
, vol.31
, pp. 125-137
-
-
Streeter, J.1
-
86
-
-
34447509674
-
Dual blockade of aldosterone and angiotensin II additively suppresses TGF-β and NADPH oxidase in the hypertensive kidney
-
M.L. Onozato Dual blockade of aldosterone and angiotensin II additively suppresses TGF-β and NADPH oxidase in the hypertensive kidney Nephrol. Dial. Transpl. 22 2007 1314 1322
-
(2007)
Nephrol. Dial. Transpl.
, vol.22
, pp. 1314-1322
-
-
Onozato, M.L.1
-
87
-
-
77949760277
-
Novel aspects of the roles of Rac1 GTPase in the cardiovascular system
-
N. Sawada Novel aspects of the roles of Rac1 GTPase in the cardiovascular system Curr. Opin. Pharmacol. 10 2010 116 121
-
(2010)
Curr. Opin. Pharmacol.
, vol.10
, pp. 116-121
-
-
Sawada, N.1
-
88
-
-
79959746706
-
The effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (Study of Heart and Renal Protection): A randomised placebo-controlled trial
-
C. Baigent The effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (Study of Heart and Renal Protection): a randomised placebo-controlled trial Lancet 377 2011 2181 2192
-
(2011)
Lancet
, vol.377
, pp. 2181-2192
-
-
Baigent, C.1
-
89
-
-
84865628946
-
Benefits and harms of statin therapy for persons with chronic kidney disease: A systematic review and meta-analysis
-
S.C. Palmer Benefits and harms of statin therapy for persons with chronic kidney disease: a systematic review and meta-analysis Ann. Intern. Med. 157 2012 263 275
-
(2012)
Ann. Intern. Med.
, vol.157
, pp. 263-275
-
-
Palmer, S.C.1
-
90
-
-
84893736247
-
Lipid-lowering treatment and inflammatory mediators in diabetes and chronic kidney disease
-
T. Almquist Lipid-lowering treatment and inflammatory mediators in diabetes and chronic kidney disease Eur. J. Clin. Invest. 44 2014 276 284
-
(2014)
Eur. J. Clin. Invest.
, vol.44
, pp. 276-284
-
-
Almquist, T.1
-
91
-
-
34047235730
-
Deletion of protein kinase C-epsilon signaling pathway induces glomerulosclerosis and tubulointerstitial fibrosis in vivo
-
M. Meier Deletion of protein kinase C-epsilon signaling pathway induces glomerulosclerosis and tubulointerstitial fibrosis in vivo J. Am. Soc. Nephrol. 18 2007 1190 1198
-
(2007)
J. Am. Soc. Nephrol.
, vol.18
, pp. 1190-1198
-
-
Meier, M.1
-
92
-
-
67651099018
-
Inhibition of protein kinase C in diabetic nephropathy - Where do we stand?
-
J. Menne Inhibition of protein kinase C in diabetic nephropathy - where do we stand? Nephrol. Dial. Transplant. 24 2009 2021 2023
-
(2009)
Nephrol. Dial. Transplant.
, vol.24
, pp. 2021-2023
-
-
Menne, J.1
-
93
-
-
84875431757
-
Dual inhibition of classical protein kinase C-alpha and protein kinase C-beta isoforms protects against experimental murine diabetic nephropathy
-
J. Menne Dual inhibition of classical protein kinase C-alpha and protein kinase C-beta isoforms protects against experimental murine diabetic nephropathy Diabetes 62 2013 1167 1174
-
(2013)
Diabetes
, vol.62
, pp. 1167-1174
-
-
Menne, J.1
-
94
-
-
28644442122
-
The effect of ruboxistaurin on nephropathy in type 2 diabetes
-
K.R. Tuttle The effect of ruboxistaurin on nephropathy in type 2 diabetes Diabetes Care 28 2005 2686 2690
-
(2005)
Diabetes Care
, vol.28
, pp. 2686-2690
-
-
Tuttle, K.R.1
-
95
-
-
77955644910
-
NF-kappaB in renal inflammation
-
A.B. Sanz NF-kappaB in renal inflammation J. Am. Soc. Nephrol. 21 2010 1254 1262
-
(2010)
J. Am. Soc. Nephrol.
, vol.21
, pp. 1254-1262
-
-
Sanz, A.B.1
-
96
-
-
20144383831
-
Extremely potent triterpenoid inducers of the phase 2 response: Correlations of protection against oxidant and inflammatory stress
-
A.T. Dinkova-Kostova Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stress Proc. Natl. Acad. Sci. U. S. A. 102 2005 4584 4589
-
(2005)
Proc. Natl. Acad. Sci. U. S. A.
, vol.102
, pp. 4584-4589
-
-
Dinkova-Kostova, A.T.1
-
97
-
-
79953242026
-
New synthetic triterpenoids: Potent agents for prevention and treatment of tissue injury caused by inflammatory and oxidative stress
-
M.B. Sporn New synthetic triterpenoids: potent agents for prevention and treatment of tissue injury caused by inflammatory and oxidative stress J. Nat. Prod. 74 2011 537 545
-
(2011)
J. Nat. Prod.
, vol.74
, pp. 537-545
-
-
Sporn, M.B.1
-
98
-
-
79960855656
-
Bardoxolone methyl and kidney function in CKD with type 2 diabetes
-
P.E. Pergola Bardoxolone methyl and kidney function in CKD with type 2 diabetes N. Engl. J. Med. 365 2011 327 336
-
(2011)
N. Engl. J. Med.
, vol.365
, pp. 327-336
-
-
Pergola, P.E.1
-
99
-
-
84869239084
-
A novel CC chemokine receptor 2 antagonist prevents progression of albuminuria and atherosclerosis in mouse models
-
M. Okamoto A novel CC chemokine receptor 2 antagonist prevents progression of albuminuria and atherosclerosis in mouse models Biol. Pharm. Bull. 35 2011 2069 2074
-
(2011)
Biol. Pharm. Bull.
, vol.35
, pp. 2069-2074
-
-
Okamoto, M.1
-
100
-
-
84863886684
-
Characterization of CCX140-B, an orally bioavailable antagonist of the CCR2 chemokine receptor, for the treatment of type 2 diabetes and associated complications
-
T.J. Sullivan Characterization of CCX140-B, an orally bioavailable antagonist of the CCR2 chemokine receptor, for the treatment of type 2 diabetes and associated complications J. Pharmacol. Exp. Ther. 342 2012 234
-
(2012)
J. Pharmacol. Exp. Ther.
, vol.342
, pp. 234
-
-
Sullivan, T.J.1
-
101
-
-
0036098758
-
Male fertility: Core chemical structure in pharmacological research
-
M. Bonanomi Male fertility: core chemical structure in pharmacological research Contraception 65 2002 317 320
-
(2002)
Contraception
, vol.65
, pp. 317-320
-
-
Bonanomi, M.1
-
102
-
-
80052097156
-
Antiproteinuric effect of chemokine C-C motif ligand 2 inhibition in subjects with acute proliferative lupus nephritis
-
A. Ble Antiproteinuric effect of chemokine C-C motif ligand 2 inhibition in subjects with acute proliferative lupus nephritis Am. J. Nephrol. 34 2011 367 372
-
(2011)
Am. J. Nephrol.
, vol.34
, pp. 367-372
-
-
Ble, A.1
-
103
-
-
84855643283
-
Bindarit: An anti-inflammatory small molecule that modulates the NFkappaB pathway
-
E. Mora Bindarit: an anti-inflammatory small molecule that modulates the NFkappaB pathway Cell Cycle 11 2012 159 169
-
(2012)
Cell Cycle
, vol.11
, pp. 159-169
-
-
Mora, E.1
-
104
-
-
23744514571
-
Pyridoxamine: The many virtues of a maillard reaction inhibitor
-
P.A. Voziyan, and B.G. Hudson Pyridoxamine: the many virtues of a maillard reaction inhibitor Ann. N. Y. Acad. Sci. 1043 2005 807 816
-
(2005)
Ann. N. Y. Acad. Sci.
, vol.1043
, pp. 807-816
-
-
Voziyan, P.A.1
Hudson, B.G.2
-
105
-
-
84863393388
-
Pyridorin in type 2 diabetic nephropathy
-
E.J. Lewis Pyridorin in type 2 diabetic nephropathy J. Am. Soc. Nephrol. 23 2012 131 136
-
(2012)
J. Am. Soc. Nephrol.
, vol.23
, pp. 131-136
-
-
Lewis, E.J.1
-
106
-
-
70449650467
-
Anti-glycation and anti-albuminuric effects of GLY-230 in human diabetes
-
L. Kennedy Anti-glycation and anti-albuminuric effects of GLY-230 in human diabetes Am. J. Nephrol. 31 2010 110 116
-
(2010)
Am. J. Nephrol.
, vol.31
, pp. 110-116
-
-
Kennedy, L.1
-
107
-
-
0036969949
-
Effect of long-term administration of prostaglandin I2 in incipient diabetic nephropathy
-
A. Owada Effect of long-term administration of prostaglandin I2 in incipient diabetic nephropathy Nephron 92 2002 788 796
-
(2002)
Nephron
, vol.92
, pp. 788-796
-
-
Owada, A.1
-
108
-
-
58349114714
-
Amelioration of diabetic nephropathy in OLETF rats by prostaglandin I(2) analog, beraprost sodium
-
M. Watanabe Amelioration of diabetic nephropathy in OLETF rats by prostaglandin I(2) analog, beraprost sodium Am. J. Nephrol. 30 2009 1 11
-
(2009)
Am. J. Nephrol.
, vol.30
, pp. 1-11
-
-
Watanabe, M.1
-
109
-
-
40049099699
-
Oral administration of GW788388, an inhibitor of TGF-beta type i and II receptor kinases, decreases renal fibrosis
-
M. Petersen Oral administration of GW788388, an inhibitor of TGF-beta type I and II receptor kinases, decreases renal fibrosis Kidney Int. 73 2008 705 715
-
(2008)
Kidney Int.
, vol.73
, pp. 705-715
-
-
Petersen, M.1
-
110
-
-
33748939751
-
IN-1130, a novel transforming growth factor-beta type i receptor kinase (ALK5) inhibitor, suppresses renal fibrosis in obstructive nephropathy
-
J.A. Moon IN-1130, a novel transforming growth factor-beta type I receptor kinase (ALK5) inhibitor, suppresses renal fibrosis in obstructive nephropathy Kidney Int. 70 2006 1234 1243
-
(2006)
Kidney Int.
, vol.70
, pp. 1234-1243
-
-
Moon, J.A.1
-
111
-
-
77955743198
-
Phase 1 study of anti-CTGF monoclonal antibody in patients with diabetes and microalbuminuria
-
S.G. Adler Phase 1 study of anti-CTGF monoclonal antibody in patients with diabetes and microalbuminuria Clin. J. Am. Soc. Nephrol. 5 2010 1420 1428
-
(2010)
Clin. J. Am. Soc. Nephrol.
, vol.5
, pp. 1420-1428
-
-
Adler, S.G.1
-
112
-
-
45849115079
-
Antioxidant and radical scavenging properties of curcumin
-
T. Ak, and I. Gülçin Antioxidant and radical scavenging properties of curcumin Chem. Biol. Interact. 174 2008 27 37
-
(2008)
Chem. Biol. Interact.
, vol.174
, pp. 27-37
-
-
Ak, T.1
Gülçin, I.2
-
113
-
-
33748529328
-
Curcumin protects mouse brain from oxidative stress caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydro pyridine
-
A. Rajeswari Curcumin protects mouse brain from oxidative stress caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydro pyridine Eur. Rev. Med. Pharmacol. Sci. 10 2006 157
-
(2006)
Eur. Rev. Med. Pharmacol. Sci.
, vol.10
, pp. 157
-
-
Rajeswari, A.1
-
114
-
-
33748891024
-
Curcumin, the active principle of turmeric (Curcuma longa), ameliorates diabetic nephropathy in rats
-
S. Sharma Curcumin, the active principle of turmeric (Curcuma longa), ameliorates diabetic nephropathy in rats Clin. Exp. Pharmacol. Physiol. 33 2006 940 945
-
(2006)
Clin. Exp. Pharmacol. Physiol.
, vol.33
, pp. 940-945
-
-
Sharma, S.1
-
115
-
-
84871364126
-
Curcumin ameliorates diabetic nephropathy by inhibiting the activation of the SphK1-S1P signaling pathway
-
J. Huang Curcumin ameliorates diabetic nephropathy by inhibiting the activation of the SphK1-S1P signaling pathway Mol. Cell. Endocrinol. 365 2013 231 240
-
(2013)
Mol. Cell. Endocrinol.
, vol.365
, pp. 231-240
-
-
Huang, J.1
-
116
-
-
80054052195
-
Oral supplementation of turmeric attenuates proteinuria, transforming growth factor-β and interleukin-8 levels in patients with overt type 2 diabetic nephropathy: A randomized, double-blind and placebo-controlled study
-
P. Khajehdehi Oral supplementation of turmeric attenuates proteinuria, transforming growth factor-β and interleukin-8 levels in patients with overt type 2 diabetic nephropathy: a randomized, double-blind and placebo-controlled study Scand. J. Urol. Nephrol. 45 2011 365 370
-
(2011)
Scand. J. Urol. Nephrol.
, vol.45
, pp. 365-370
-
-
Khajehdehi, P.1
-
117
-
-
84871971567
-
Therapeutic roles of curcumin: Lessons learned from clinical trials
-
S.C. Gupta Therapeutic roles of curcumin: lessons learned from clinical trials AAPS J. 15 2013 195 218
-
(2013)
AAPS J.
, vol.15
, pp. 195-218
-
-
Gupta, S.C.1
-
118
-
-
77951160564
-
Pirfenidone in idiopathic pulmonary fibrosis
-
H. Taniguchi Pirfenidone in idiopathic pulmonary fibrosis Eur. Respir. J. 35 2009 821 829
-
(2009)
Eur. Respir. J.
, vol.35
, pp. 821-829
-
-
Taniguchi, H.1
-
119
-
-
0034004098
-
Pirfenidone inhibits NADPH-dependent microsomal lipid peroxidation and scavenges hydroxyl radicals
-
H.P. Misra, and C. Rabideau Pirfenidone inhibits NADPH-dependent microsomal lipid peroxidation and scavenges hydroxyl radicals Mol. Cell. Biochem. 204 2000 119 126
-
(2000)
Mol. Cell. Biochem.
, vol.204
, pp. 119-126
-
-
Misra, H.P.1
Rabideau, C.2
-
120
-
-
84877929064
-
Pirfenidone inhibits macrophage infiltration in 5/6 nephrectomized rats
-
J.F. Chen Pirfenidone inhibits macrophage infiltration in 5/6 nephrectomized rats Am. J. Physiol. Renal. Physiol. 304 2013 F676 F685
-
(2013)
Am. J. Physiol. Renal. Physiol.
, vol.304
, pp. F676-F685
-
-
Chen, J.F.1
-
121
-
-
68149178848
-
Pirfenidone is renoprotective in diabetic kidney disease
-
S.P. RamachandraRao Pirfenidone is renoprotective in diabetic kidney disease J. Am. Soc. Nephrol. 20 2009 1765 1775
-
(2009)
J. Am. Soc. Nephrol.
, vol.20
, pp. 1765-1775
-
-
Ramachandrarao, S.P.1
-
122
-
-
79957670746
-
Pirfenidone for diabetic nephropathy
-
K. Sharma Pirfenidone for diabetic nephropathy J. Am. Soc. Nephrol. 22 2011 1144 1151
-
(2011)
J. Am. Soc. Nephrol.
, vol.22
, pp. 1144-1151
-
-
Sharma, K.1
-
123
-
-
69549110735
-
Fluorofenidone attenuates collagen i and transforming growth factor-beta1 expression through a nicotinamide adenine dinucleotide phosphate oxidase-dependent way in NRK-52E cells
-
Z.Z. Peng Fluorofenidone attenuates collagen I and transforming growth factor-beta1 expression through a nicotinamide adenine dinucleotide phosphate oxidase-dependent way in NRK-52E cells Nephrology (Carlton) 14 2009 565 572
-
(2009)
Nephrology (Carlton)
, vol.14
, pp. 565-572
-
-
Peng, Z.Z.1
-
124
-
-
80051577424
-
Fluorofenidone attenuates diabetic nephropathy and kidney fibrosis in db/db mice
-
L.H. Wang Fluorofenidone attenuates diabetic nephropathy and kidney fibrosis in db/db mice Pharmacology 88 2011 88 99
-
(2011)
Pharmacology
, vol.88
, pp. 88-99
-
-
Wang, L.H.1
-
125
-
-
79959797018
-
Fluorofenidone attenuates renal interstitial fibrosis in the rat model of obstructive nephropathy
-
B.X. Li Fluorofenidone attenuates renal interstitial fibrosis in the rat model of obstructive nephropathy Mol. Cell. Biochem. 354 2011 263 273
-
(2011)
Mol. Cell. Biochem.
, vol.354
, pp. 263-273
-
-
Li, B.X.1
-
126
-
-
79960660939
-
Fluorofenidone attenuates tubulointerstitial fibrosis by inhibiting TGF-β1-induced fibroblast activation
-
Q. Yuan Fluorofenidone attenuates tubulointerstitial fibrosis by inhibiting TGF-β1-induced fibroblast activation Am. J. Nephrol. 34 2011 181 194
-
(2011)
Am. J. Nephrol.
, vol.34
, pp. 181-194
-
-
Yuan, Q.1
-
127
-
-
84862800833
-
Synthesis and structure-activity relationship of 5-substituent-2(1H)-pyridone derivatives as anti-fibrosis agents
-
J. Chen Synthesis and structure-activity relationship of 5-substituent-2(1H)-pyridone derivatives as anti-fibrosis agents Bioorg. Med. Chem. Lett. 22 2012 2300 2302
-
(2012)
Bioorg. Med. Chem. Lett.
, vol.22
, pp. 2300-2302
-
-
Chen, J.1
-
128
-
-
84863127185
-
Design, synthesis and anti-fibrosis activity study of N(1)-substituted phenylhydroquinolinone derivatives
-
L. Wu Design, synthesis and anti-fibrosis activity study of N(1)-substituted phenylhydroquinolinone derivatives Molecules 17 2012 1373 1387
-
(2012)
Molecules
, vol.17
, pp. 1373-1387
-
-
Wu, L.1
-
129
-
-
84925394754
-
Treatment of albuminuria due to diabetic nephropathy: Recent trial results
-
E.J. Horwitz, and J.R. Schelling Treatment of albuminuria due to diabetic nephropathy: recent trial results J. Clin. Invest. 4 2014 327 341
-
(2014)
J. Clin. Invest.
, vol.4
, pp. 327-341
-
-
Horwitz, E.J.1
Schelling, J.R.2
|