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Volumn 2, Issue 1-2, 2011, Pages 103-114

Aldose reductase: New insights for an old enzyme

Author keywords

aldose reductase; cancer; diabetes; inflammation; oxidative stress; sepsis; uveitis

Indexed keywords

ANIMALIA; RODENTIA;

EID: 80054054044     PISSN: 18685021     EISSN: 1868503X     Source Type: Journal    
DOI: 10.1515/bmc.2011.002     Document Type: Review
Times cited : (157)

References (109)
  • 1
    • 0000116568 scopus 로고
    • The mechanism of the transformation of glucose in fructose in the seminal vesicles
    • Hers HG. The mechanism of the transformation of glucose in fructose in the seminal vesicles. Biochim Biophys Acta 1956; 22: 202-3.
    • (1956) Biochim Biophys Acta , vol.22 , pp. 202-203
    • Hers, H.G.1
  • 2
    • 0000841548 scopus 로고
    • Formation of polyols by the lens of the rat with 'sugar' cataract
    • van Heyningen R. Formation of polyols by the lens of the rat with 'sugar' cataract. Nature 1959; 468: 194-5.
    • (1959) Nature , vol.468 , pp. 194-195
    • Van Heyningen, R.1
  • 3
    • 0014428570 scopus 로고
    • The effect of an aldose reductase inhibitor on the galactose-exposed rabbit lens
    • Kinoshita JH, Dvornik D, Kraml M, Gabbay KH. The effect of an aldose reductase inhibitor on the galactose-exposed rabbit lens. Biochim Biophys Acta 1968; 158: 472-5.
    • (1968) Biochim Biophys Acta , vol.158 , pp. 472-475
    • Kinoshita, J.H.1    Dvornik, D.2    Kraml, M.3    Gabbay, K.H.4
  • 4
    • 0017200379 scopus 로고
    • Inhibition of lens aldose reductase by flavonoids - Their possible role in the prevention of diabetic cataracts
    • Varma SD, Kinoshita JH. Inhibition of lens aldose reductase by flavonoids - their possible role in the prevention of diabetic cataracts. Biochem Pharmacol 1976; 25: 2505-13.
    • (1976) Biochem Pharmacol , vol.25 , pp. 2505-2513
    • Varma, S.D.1    Kinoshita, J.H.2
  • 6
    • 0017118637 scopus 로고
    • Sugar alcohols in the pathogenesis of galactose and diabetic cataracts
    • van Heyningen R. Sugar alcohols in the pathogenesis of galactose and diabetic cataracts. Birth Defects Orig Artic Ser 1976; 12: 295-303.
    • (1976) Birth Defects Orig Artic ser , vol.12 , pp. 295-303
    • Van Heyningen, R.1
  • 7
    • 0015929739 scopus 로고
    • The sorbitol pathway and the complications of diabetes
    • Gabbay KH. The sorbitol pathway and the complications of diabetes. N Engl J Med 1973; 288: 831-6.
    • (1973) N Engl J Med , vol.288 , pp. 831-836
    • Gabbay, K.H.1
  • 8
    • 0019363254 scopus 로고
    • The biochemistry of the complications of diabetes mellitus
    • Brownlee M, Cerami A. The biochemistry of the complications of diabetes mellitus. Annu Rev Biochem 1981; 50: 385-432.
    • (1981) Annu Rev Biochem , vol.50 , pp. 385-432
    • Brownlee, M.1    Cerami, A.2
  • 9
    • 77950168857 scopus 로고    scopus 로고
    • Aldose reductase inhibitors and diabetic kidney disease
    • Oates PJ. Aldose reductase inhibitors and diabetic kidney disease. Curr Opin Investig Drugs 2010; 11: 402-17.
    • (2010) Curr Opin Investig Drugs , vol.11 , pp. 402-417
    • Oates, P.J.1
  • 10
    • 77956227831 scopus 로고    scopus 로고
    • Aldose reductase inhibitors in the treatment of diabetic peripheral neuropathy: A review
    • Schemmel KE, Padiyara RS, D'Souza JJ. Aldose reductase inhibitors in the treatment of diabetic peripheral neuropathy: a review. J Diabetes Complications 2010; 24: 354-60.
    • (2010) J Diabetes Complications , vol.24 , pp. 354-360
    • Schemmel, K.E.1    Padiyara, R.S.2    D'Souza, J.J.3
  • 11
    • 18844369302 scopus 로고    scopus 로고
    • Role of aldose reductase and oxidative damage in diabetes and the consequent potential for therapeutic options
    • Srivastava SK, Ramana KV, Bhatnagar A. Role of aldose reductase and oxidative damage in diabetes and the consequent potential for therapeutic options. Endocr Rev 2005; 26: 380-92.
    • (2005) Endocr Rev , vol.26 , pp. 380-392
    • Srivastava, S.K.1    Ramana, K.V.2    Bhatnagar, A.3
  • 13
    • 0028946316 scopus 로고
    • Demonstration that polyol accumulation is responsible for diabetic cataract by the use of transgenic mice expressing the aldose reductase gene in the lens
    • Lee AY, Chung SK, Chung SS. Demonstration that polyol accumulation is responsible for diabetic cataract by the use of transgenic mice expressing the aldose reductase gene in the lens. Proc Natl Acad Sci USA 1995; 92: 2780-4.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 2780-2784
    • Lee, A.Y.1    Chung, S.K.2    Chung, S.S.3
  • 17
    • 0025306966 scopus 로고
    • Allopurinol promotes and butylated hydroxy toluene prevents sugar-induced cataractogenesis
    • Ansari NH, Srivastava SK. Allopurinol promotes and butylated hydroxy toluene prevents sugar-induced cataractogenesis. Biochem Biophys Res Commun 1990; 168: 939-43.
    • (1990) Biochem Biophys Res Commun , vol.168 , pp. 939-943
    • Ansari, N.H.1    Srivastava, S.K.2
  • 18
    • 0027374230 scopus 로고
    • Digital image analysis of cultured rat lens during oxidative stressinduced cataractogenesis
    • Bhatnagar A, Ansari NH, Zacarias A, Srivastava SK. Digital image analysis of cultured rat lens during oxidative stressinduced cataractogenesis. Exp Eye Res 1993; 57: 385-91.
    • (1993) Exp Eye Res , vol.57 , pp. 385-391
    • Bhatnagar, A.1    Ansari, N.H.2    Zacarias, A.3    Srivastava, S.K.4
  • 19
    • 0026443085 scopus 로고
    • The crystal structure of the aldose reductase. NADPH binary complex
    • Borhani DW, Harter TM, Petrash JM. The crystal structure of the aldose reductase. NADPH binary complex. J Biol Chem 1992; 267: 24841-7.
    • (1992) J Biol Chem , vol.267 , pp. 24841-24847
    • Borhani, D.W.1    Harter, T.M.2    Petrash, J.M.3
  • 21
    • 0029562272 scopus 로고
    • Lipid peroxidation product, 4-hydroxynonenal and its conjugate with GSH are excellent substrates of bovine lens aldose reductase
    • Srivastava S, Chandra A, Bhatnagar A, Srivastava SK, Ansari NH. Lipid peroxidation product, 4-hydroxynonenal and its conjugate with GSH are excellent substrates of bovine lens aldose reductase. Biochem Biophys Res Commun 1995; 217: 741-6.
    • (1995) Biochem Biophys Res Commun , vol.217 , pp. 741-746
    • Srivastava, S.1    Chandra, A.2    Bhatnagar, A.3    Srivastava, S.K.4    Ansari, N.H.5
  • 29
    • 0032947546 scopus 로고    scopus 로고
    • Aldose reductase functions as a detoxification system for lipid peroxidation products in vasculitis
    • Rittner HL, Hafner V, Klimiuk PA, Szweda LI, Goronzy JJ, Weyand CM. Aldose reductase functions as a detoxification system for lipid peroxidation products in vasculitis. J Clin Invest 1999; 103: 1007-13.
    • (1999) J Clin Invest , vol.103 , pp. 1007-1013
    • Rittner, H.L.1    Hafner, V.2    Klimiuk, P.A.3    Szweda, L.I.4    Goronzy, J.J.5    Weyand, C.M.6
  • 30
    • 77956234404 scopus 로고    scopus 로고
    • Reactive oxygen species and α,β-unsaturated aldehydes as second messengers in signal transduction
    • Forman HJ. Reactive oxygen species and α,β-unsaturated aldehydes as second messengers in signal transduction. Ann NY Acad Sci 2010; 1203: 35-44.
    • (2010) Ann NY Acad Sci , vol.1203 , pp. 35-44
    • Forman, H.J.1
  • 31
    • 35449006744 scopus 로고    scopus 로고
    • Lipid peroxidation and redox-sensitive signaling pathways
    • Uchida K. Lipid peroxidation and redox-sensitive signaling pathways. Curr Atheroscler Rep 2007; 9: 216-21.
    • (2007) Curr Atheroscler Rep , vol.9 , pp. 216-221
    • Uchida, K.1
  • 32
    • 33846822132 scopus 로고    scopus 로고
    • Apoptosis signaling by 4-hydroxynonenal: A role for JNK-c-Jun/AP-1 pathway
    • Kutuk O, Basaga H. Apoptosis signaling by 4-hydroxynonenal: a role for JNK-c-Jun/AP-1 pathway. Redox Rep 2007; 12: 30-4.
    • (2007) Redox Rep , vol.12 , pp. 30-34
    • Kutuk, O.1    Basaga, H.2
  • 35
    • 0037313234 scopus 로고    scopus 로고
    • Aldose reductase mediates cytotoxic signals of hyperglycemia and TNF-α in human lens epithelial cells
    • Ramana KV, Friedrich B, Bhatnagar A, Srivastava SK. Aldose reductase mediates cytotoxic signals of hyperglycemia and TNF-α in human lens epithelial cells. FASEB J 2003; 17: 315-7.
    • (2003) FASEB J , vol.17 , pp. 315-317
    • Ramana, K.V.1    Friedrich, B.2    Bhatnagar, A.3    Srivastava, S.K.4
  • 36
    • 3442900756 scopus 로고    scopus 로고
    • Inhibition of aldose reductase attenuates TNF-α-induced expression of adhesion molecules in endothelial cells
    • Ramana KV, Bhatnagar A, Srivastava SK. Inhibition of aldose reductase attenuates TNF-α-induced expression of adhesion molecules in endothelial cells. FASEB J 2004; 18: 1209-18.
    • (2004) FASEB J , vol.18 , pp. 1209-1218
    • Ramana, K.V.1    Bhatnagar, A.2    Srivastava, S.K.3
  • 37
    • 33750286521 scopus 로고    scopus 로고
    • Aldose reductase regulates growth factor-induced cyclooxygenase-2 expression and prostaglandin E2 production in human colon cancer cells
    • Tammali R, Ramana KV, Singhal SS, Awasthi S, Srivastava SK. Aldose reductase regulates growth factor-induced cyclooxygenase-2 expression and prostaglandin E2 production in human colon cancer cells. Cancer Res 2006; 66: 9705-13.
    • (2006) Cancer Res , vol.66 , pp. 9705-9713
    • Tammali, R.1    Ramana, K.V.2    Singhal, S.S.3    Awasthi, S.4    Srivastava, S.K.5
  • 39
    • 0029112492 scopus 로고
    • An (A-C)n dinucleotide repeat polymorphic marker at the 5′ end of the aldose reductase gene is associated with early-onset diabetic retinopathy in NIDDM patients
    • Ko BC, Lam KS, Wat NM, Chung SS. An (A-C)n dinucleotide repeat polymorphic marker at the 5′ end of the aldose reductase gene is associated with early-onset diabetic retinopathy in NIDDM patients. Diabetes 1995; 44: 727-32.
    • (1995) Diabetes , vol.44 , pp. 727-732
    • Ko, B.C.1    Lam, K.S.2    Wat, N.M.3    Chung, S.S.4
  • 40
    • 0031920364 scopus 로고    scopus 로고
    • Susceptibility to diabetic neuropathy in patients with insulin dependent diabetes mellitus is associated with a polymorphism at the 5′ end of the aldose reductase gene
    • Heesom AE, Millward A, Demaine AG. Susceptibility to diabetic neuropathy in patients with insulin dependent diabetes mellitus is associated with a polymorphism at the 5′ end of the aldose reductase gene. J Neurol Neurosurg Psych 1998; 64: 213-6.
    • (1998) J Neurol Neurosurg Psych , vol.64 , pp. 213-216
    • Heesom, A.E.1    Millward, A.2    Demaine, A.G.3
  • 41
    • 0032711922 scopus 로고    scopus 로고
    • An aldose reductase intragenic polymorphism associated with diabetic retinopathy
    • Kao YL, Donaghue K, Chan A, Knight J, Silink M. An aldose reductase intragenic polymorphism associated with diabetic retinopathy. Diabetes Res Clin Pract 1999; 46: 155-60.
    • (1999) Diabetes Res Clin Pract , vol.46 , pp. 155-160
    • Kao, Y.L.1    Donaghue, K.2    Chan, A.3    Knight, J.4    Silink, M.5
  • 44
    • 0036192529 scopus 로고    scopus 로고
    • Polymorphisms and functions of the aldose reductase gene 59 regulatory region in Chinese patients with type 2 diabetes mellitus
    • Li Q, Xie P, Huang J, Gu Y, Zeng W, Song H. Polymorphisms and functions of the aldose reductase gene 59 regulatory region in Chinese patients with type 2 diabetes mellitus. Chin Med J (Engl) 2002; 115: 209-13.
    • (2002) Chin Med J (Engl) , vol.115 , pp. 209-213
    • Li, Q.1    Xie, P.2    Huang, J.3    Gu, Y.4    Zeng, W.5    Song, H.6
  • 45
    • 3342925853 scopus 로고    scopus 로고
    • Aldose reductase gene polymorphisms and peripheral nerve function in patients with type 2 diabetes
    • Sivenius K, Pihlajamäki J, Partanen J, Niskanen L, Laakso M, Uusitupa M. Aldose reductase gene polymorphisms and peripheral nerve function in patients with type 2 diabetes. Diabetes Care 2004; 27: 2021-6.
    • (2004) Diabetes Care , vol.27 , pp. 2021-2026
    • Sivenius, K.1    Pihlajamäki, J.2    Partanen, J.3    Niskanen, L.4    Laakso, M.5    Uusitupa, M.6
  • 47
    • 33745892100 scopus 로고    scopus 로고
    • Mitogenic responses of vascular smooth muscle cells to lipid peroxidation-derived aldehyde 4-hydroxy-trans-2-nonenal (HNE): Role of aldose reductase-catalyzed reduction of the HNE-glutathione conjugates in regulating cell growth
    • Ramana KV, Bhatnagar A, Srivastava S, Yadav UC, Awasthi S, Awasthi YC, Srivastava SK. Mitogenic responses of vascular smooth muscle cells to lipid peroxidation-derived aldehyde 4-hydroxy-trans-2-nonenal (HNE): role of aldose reductase-catalyzed reduction of the HNE-glutathione conjugates in regulating cell growth. J Biol Chem 2006; 281: 17652-60.
    • (2006) J Biol Chem , vol.281 , pp. 17652-17660
    • Ramana, K.V.1    Bhatnagar, A.2    Srivastava, S.3    Yadav, U.C.4    Awasthi, S.5    Awasthi, Y.C.6    Srivastava, S.K.7
  • 49
    • 54749095969 scopus 로고    scopus 로고
    • 4-hydroxynonenal induces apoptosis in human osteoarthritic chondrocytes: The protective role of glutathione-S-transferase
    • Vaillancourt F, Fahmi H, Shi Q, Lavigne P, Ranger P, Fernandes JC, Benderdour M. 4-Hydroxynonenal induces apoptosis in human osteoarthritic chondrocytes: the protective role of glutathione-S-transferase. Arthritis Res Ther 2008; 10: R107.
    • (2008) Arthritis Res Ther , vol.10 , pp. R107
    • Vaillancourt, F.1    Fahmi, H.2    Shi, Q.3    Lavigne, P.4    Ranger, P.5    Fernandes, J.C.6    Benderdour, M.7
  • 52
    • 57549118957 scopus 로고    scopus 로고
    • Focus on molecules: Nuclear factor-kB
    • Srivastava SK, Ramana KV. Focus on molecules: nuclear factor-kB. Exp Eye Res 2009; 88: 2-3.
    • (2009) Exp Eye Res , vol.88 , pp. 2-3
    • Srivastava, S.K.1    Ramana, K.V.2
  • 53
    • 53749104872 scopus 로고    scopus 로고
    • Mechanism of copper-activated transcription: Activation of AP-1, and the JNK/SAPK and p38 signal transduction pathways
    • Mattie MD, McElwee MK, Freedman JH. Mechanism of copper-activated transcription: activation of AP-1, and the JNK/SAPK and p38 signal transduction pathways. J Mol Biol 2008; 383: 1008-18.
    • (2008) J Mol Biol , vol.383 , pp. 1008-1018
    • Mattie, M.D.1    McElwee, M.K.2    Freedman, J.H.3
  • 55
    • 34447096817 scopus 로고    scopus 로고
    • Ascofuranone suppresses PMAmediated matrix metalloproteinase-9 gene activation through the Ras/Raf/MEK/ERK- and Ap1-dependent mechanisms
    • Cho HJ, Kang JH, Kwak JY, Lee TS, Lee IS, Park NG, Nakajima H, Magae J, Chang YC. Ascofuranone suppresses PMAmediated matrix metalloproteinase-9 gene activation through the Ras/Raf/MEK/ERK- and Ap1-dependent mechanisms. Carcinogenesis 2007; 28: 1104-10.
    • (2007) Carcinogenesis , vol.28 , pp. 1104-1110
    • Cho, H.J.1    Kang, J.H.2    Kwak, J.Y.3    Lee, T.S.4    Lee, I.S.5    Park, N.G.6    Nakajima, H.7    Magae, J.8    Chang, Y.C.9
  • 56
    • 33947250147 scopus 로고    scopus 로고
    • Aldose reductase mediates endotoxin-induced production of nitric oxide and cytotoxicity in murine macrophages
    • Ramana KV, Reddy AB, Tammali R, Srivastava SK. Aldose reductase mediates endotoxin-induced production of nitric oxide and cytotoxicity in murine macrophages. Free Radic Biol Med 2007; 42: 1290-302.
    • (2007) Free Radic Biol Med , vol.42 , pp. 1290-1302
    • Ramana, K.V.1    Reddy, A.B.2    Tammali, R.3    Srivastava, S.K.4
  • 57
    • 3142646780 scopus 로고    scopus 로고
    • Aldose reductase regulates TNF-α-induced cell signaling and apoptosis in vascular endothelial cells
    • Ramana KV, Bhatnagar A, Srivastava SK. Aldose reductase regulates TNF-α-induced cell signaling and apoptosis in vascular endothelial cells. FEBS Lett 2004; 570: 189-94.
    • (2004) FEBS Lett , vol.570 , pp. 189-194
    • Ramana, K.V.1    Bhatnagar, A.2    Srivastava, S.K.3
  • 58
    • 39149093682 scopus 로고    scopus 로고
    • Glutathione level regulates HNE-induced genotoxicity in human erythroleukemia cells
    • Yadav UC, Ramana KV, Awasthi YC, Srivastava SK. Glutathione level regulates HNE-induced genotoxicity in human erythroleukemia cells. Toxicol Appl Pharmacol 2008; 227: 257-64.
    • (2008) Toxicol Appl Pharmacol , vol.227 , pp. 257-264
    • Yadav, U.C.1    Ramana, K.V.2    Awasthi, Y.C.3    Srivastava, S.K.4
  • 59
    • 26944435572 scopus 로고    scopus 로고
    • Genotoxicity of 4-hydroxy-2-nonenal in human colon tumor cells is associated with cellular levels of glutathione and the modulation of glutathione S-transferase A4 expression by butyrate
    • Knoll N, Ruhe C, Veeriah S, Sauer J, Glei M, Gallagher EP, Pool-Zobel BL. Genotoxicity of 4-hydroxy-2-nonenal in human colon tumor cells is associated with cellular levels of glutathione and the modulation of glutathione S-transferase A4 expression by butyrate. Toxicol Sci 2005; 86: 27-35.
    • (2005) Toxicol Sci , vol.86 , pp. 27-35
    • Knoll, N.1    Ruhe, C.2    Veeriah, S.3    Sauer, J.4    Glei, M.5    Gallagher, E.P.6    Pool-Zobel, B.L.7
  • 65
    • 0345269946 scopus 로고    scopus 로고
    • Long-term combined supplementations with α-tocopherol and vitamin C have no detectable antiinflammatory effects in healthy men
    • Bruunsgaard H, Poulsen HE, Pedersen BK, Nyyssonen K, Kaikkonen J, Salonen JT. Long-term combined supplementations with α-tocopherol and vitamin C have no detectable antiinflammatory effects in healthy men. J Nutr 2003; 133: 1170-3.
    • (2003) J Nutr , vol.133 , pp. 1170-1173
    • Bruunsgaard, H.1    Poulsen, H.E.2    Pedersen, B.K.3    Nyyssonen, K.4    Kaikkonen, J.5    Salonen, J.T.6
  • 66
    • 0034705619 scopus 로고    scopus 로고
    • Overexpression of catalase in the mitochondrial or cytosolic compartment increases sensitivity of HepG2 cells to tumor necrosis factor-α-induced apoptosis
    • Bai J, Cederbaum AI. Overexpression of catalase in the mitochondrial or cytosolic compartment increases sensitivity of HepG2 cells to tumor necrosis factor-α-induced apoptosis. J Biol Chem 2000; 275: 19241-9.
    • (2000) J Biol Chem , vol.275 , pp. 19241-19249
    • Bai, J.1    Cederbaum, A.I.2
  • 67
    • 13244270147 scopus 로고    scopus 로고
    • Superoxide dismutase inhibits the expression of vascular cell adhesion molecule-1 and intracellular cell adhesion molecule-1 induced by tumor necrosis factor-α in human endothelial cells through the JNK/p38 pathways
    • Lin SJ, Shyue SK, Hung YY, Chen YH, Ku HH, Chen JW, Tam KB, Chen YL. Superoxide dismutase inhibits the expression of vascular cell adhesion molecule-1 and intracellular cell adhesion molecule-1 induced by tumor necrosis factor-α in human endothelial cells through the JNK/p38 pathways. Arterioscler Thromb Vasc Biol 2005; 25: 334-40.
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , pp. 334-340
    • Lin, S.J.1    Shyue, S.K.2    Hung, Y.Y.3    Chen, Y.H.4    Ku, H.H.5    Chen, J.W.6    Tam, K.B.7    Chen, Y.L.8
  • 68
    • 22944467832 scopus 로고    scopus 로고
    • Oxidative stress-related molecules as a therapeutic target for inflammatory and allergic diseases
    • Naito Y, Takano H, Yoshikawa T. Oxidative stress-related molecules as a therapeutic target for inflammatory and allergic diseases. Curr Drug Targets Inflamm Allergy 2005; 4: 511-5.
    • (2005) Curr Drug Targets Inflamm Allergy , vol.4 , pp. 511-515
    • Naito, Y.1    Takano, H.2    Yoshikawa, T.3
  • 69
    • 21644434092 scopus 로고    scopus 로고
    • Relief from a heavy heart: Redox-sensitive NFkB as a therapeutic target in managing cardiac hypertrophy
    • Sen CK, Roy S. Relief from a heavy heart: redox-sensitive NFkB as a therapeutic target in managing cardiac hypertrophy. Am J Physiol Heart Circ Physiol 2005; 289: 17-9.
    • (2005) Am J Physiol Heart Circ Physiol , vol.289 , pp. 17-19
    • Sen, C.K.1    Roy, S.2
  • 72
    • 0028109394 scopus 로고
    • Evidence for the involvement of interleukin 10 in the differential deactivation of murine peritoneal macrophages by prostaglandin E2
    • Strassmann G, Patil-Koota V, Finkelman F, Fong M, Kambayashi T. Evidence for the involvement of interleukin 10 in the differential deactivation of murine peritoneal macrophages by prostaglandin E2. J Exp Med 1994; 180: 2365-70.
    • (1994) J Exp Med , vol.180 , pp. 2365-2370
    • Strassmann, G.1    Patil-Koota, V.2    Finkelman, F.3    Fong, M.4    Kambayashi, T.5
  • 74
    • 0035969875 scopus 로고    scopus 로고
    • The role of aldose reductase in sugar cataract formation: Aldose reductase plays a key role in lens epithelial cell death (apoptosis)
    • Murata M, Ohta N, Sakurai S, Alam S, Tsai J, Kador PF, Sato S. The role of aldose reductase in sugar cataract formation: aldose reductase plays a key role in lens epithelial cell death (apoptosis). Chem Biol Interact 2001; 130-132: 617-25.
    • (2001) Chem Biol Interact , vol.130-132 , pp. 617-625
    • Murata, M.1    Ohta, N.2    Sakurai, S.3    Alam, S.4    Tsai, J.5    Kador, P.F.6    Sato, S.7
  • 75
    • 0027434707 scopus 로고
    • Aldose reductase inhibition restores endothelial cell function in diabetic rabbit aorta
    • Tesfamariam B, Palacino JJ, Weisbrod RM, Cohen RA. Aldose reductase inhibition restores endothelial cell function in diabetic rabbit aorta. J Cardiovasc Pharmacol 1993; 21: 205-11.
    • (1993) J Cardiovasc Pharmacol , vol.21 , pp. 205-211
    • Tesfamariam, B.1    Palacino, J.J.2    Weisbrod, R.M.3    Cohen, R.A.4
  • 76
    • 33745305992 scopus 로고    scopus 로고
    • Contribution of aldose reductase to diabetic hyperproliferation of vascular smooth muscle cells
    • Srivastava S, Ramana KV, Tammali R, Srivastava SK, Bhatnagar A. Contribution of aldose reductase to diabetic hyperproliferation of vascular smooth muscle cells. Diabetes 2006; 55: 901-10.
    • (2006) Diabetes , vol.55 , pp. 901-910
    • Srivastava, S.1    Ramana, K.V.2    Tammali, R.3    Srivastava, S.K.4    Bhatnagar, A.5
  • 78
    • 0027981889 scopus 로고
    • Characterization of the mechanism for the chronic activation of diacylglycerol-protein kinase C pathway in diabetes and hypergalactosemia
    • Xia P, Inoguchi T, Kern TS, Engerman RL, Oates PJ, King GL. Characterization of the mechanism for the chronic activation of diacylglycerol-protein kinase C pathway in diabetes and hypergalactosemia. Diabetes 1994; 43: 1122-9.
    • (1994) Diabetes , vol.43 , pp. 1122-1129
    • Xia, P.1    Inoguchi, T.2    Kern, T.S.3    Engerman, R.L.4    Oates, P.J.5    King, G.L.6
  • 79
    • 14644387496 scopus 로고    scopus 로고
    • Requirement of aldose reductase for the hyperglycemic activation of protein kinase C and formation of diacylglycerol in vascular smooth muscle cells
    • Ramana KV, Friedrich B, Tammali R, West MB, Bhatnagar A, Srivastava SK. Requirement of aldose reductase for the hyperglycemic activation of protein kinase C and formation of diacylglycerol in vascular smooth muscle cells. Diabetes 2005; 54: 818-29.
    • (2005) Diabetes , vol.54 , pp. 818-829
    • Ramana, K.V.1    Friedrich, B.2    Tammali, R.3    West, M.B.4    Bhatnagar, A.5    Srivastava, S.K.6
  • 80
    • 7044247670 scopus 로고    scopus 로고
    • Activation of nuclear factor-κB by hyperglycemia in vascular smooth muscle cells is regulated by aldose reductase
    • Ramana KV, Friedrich B, Srivastava S, Bhatnagar A, Srivastava SK. Activation of nuclear factor-κB by hyperglycemia in vascular smooth muscle cells is regulated by aldose reductase. Diabetes 2004; 53: 2910-20.
    • (2004) Diabetes , vol.53 , pp. 2910-2920
    • Ramana, K.V.1    Friedrich, B.2    Srivastava, S.3    Bhatnagar, A.4    Srivastava, S.K.5
  • 81
    • 77953169082 scopus 로고    scopus 로고
    • Aldose reductase regulates vascular smooth muscle cell proliferation by modulating G1/S phase transition of cell cycle
    • Tammali R, Saxena A, Srivastava SK, Ramana KV. Aldose reductase regulates vascular smooth muscle cell proliferation by modulating G1/S phase transition of cell cycle. Endocrinology 2010; 151: 2140-50.
    • (2010) Endocrinology , vol.151 , pp. 2140-2150
    • Tammali, R.1    Saxena, A.2    Srivastava, S.K.3    Ramana, K.V.4
  • 82
    • 77950830294 scopus 로고    scopus 로고
    • Inhibition of aldose reductase prevents growth factor-induced G1-S phase transition through the AKT/phosphoinositide 3-kinase/E2F-1 pathway in human colon cancer cells
    • Ramana KV, Tammali R, Srivastava SK. Inhibition of aldose reductase prevents growth factor-induced G1-S phase transition through the AKT/phosphoinositide 3-kinase/E2F-1 pathway in human colon cancer cells. Mol Cancer Ther 2010; 9: 813-24.
    • (2010) Mol Cancer Ther , vol.9 , pp. 813-824
    • Ramana, K.V.1    Tammali, R.2    Srivastava, S.K.3
  • 83
    • 34548084566 scopus 로고    scopus 로고
    • Aldose reductase-regulated tumor necrosis factor-α production is essential for high glucose-induced vascular smooth muscle cell growth
    • Ramana KV, Tammali R, Reddy AB, Bhatnagar A, Srivastava SK. Aldose reductase-regulated tumor necrosis factor-α production is essential for high glucose-induced vascular smooth muscle cell growth. Endocrinology 2007; 148: 4371-84.
    • (2007) Endocrinology , vol.148 , pp. 4371-4384
    • Ramana, K.V.1    Tammali, R.2    Reddy, A.B.3    Bhatnagar, A.4    Srivastava, S.K.5
  • 84
    • 58149475666 scopus 로고    scopus 로고
    • Aldose reductase regulates high glucose-induced ectodomain shedding of tumor necrosis factor (TNF)-α via protein kinase C-δ and TNF-α converting enzyme in vascular smooth muscle cells
    • Reddy AB, Ramana KV, Srivastava S, Bhatnagar A, Srivastava SK. Aldose reductase regulates high glucose-induced ectodomain shedding of tumor necrosis factor (TNF)-α via protein kinase C-δ and TNF-α converting enzyme in vascular smooth muscle cells. Endocrinology 2009; 150: 63-74.
    • (2009) Endocrinology , vol.150 , pp. 63-74
    • Reddy, A.B.1    Ramana, K.V.2    Srivastava, S.3    Bhatnagar, A.4    Srivastava, S.K.5
  • 85
    • 77953809886 scopus 로고    scopus 로고
    • Aldose reductase inhibition prevents lipopolysaccharide-induced glucose uptake and glucose transporter 3 expression in RAW264.7 macrophages
    • Reddy AB, Srivastava SK, Ramana KV. Aldose reductase inhibition prevents lipopolysaccharide-induced glucose uptake and glucose transporter 3 expression in RAW264.7 macrophages. Int J Biochem Cell Biol 2010; 42: 1039-45.
    • (2010) Int J Biochem Cell Biol , vol.42 , pp. 1039-1045
    • Reddy, A.B.1    Srivastava, S.K.2    Ramana, K.V.3
  • 86
    • 18144381538 scopus 로고    scopus 로고
    • Aldose reductase pathway mediates JAK-STAT signaling: A novel axis in myocardial ischemic injury
    • Hwang YC, Shaw S, Kaneko M, Redd H, Marrero MB, Ramasamy R. Aldose reductase pathway mediates JAK-STAT signaling: a novel axis in myocardial ischemic injury. FASEB J 2005; 19: 795-7.
    • (2005) FASEB J , vol.19 , pp. 795-797
    • Hwang, Y.C.1    Shaw, S.2    Kaneko, M.3    Redd, H.4    Marrero, M.B.5    Ramasamy, R.6
  • 87
    • 33845962827 scopus 로고    scopus 로고
    • Aldose reductase mediates the lipopolysaccharide-induced release of inflammatory mediators in RAW264.7 murine macrophages
    • Ramana KV, Fadl AA, Tammali R, Reddy AB, Chopra AK, Srivastava SK. Aldose reductase mediates the lipopolysaccharide-induced release of inflammatory mediators in RAW264.7 murine macrophages. J Biol Chem 2006; 281: 33019-29.
    • (2006) J Biol Chem , vol.281 , pp. 33019-33029
    • Ramana, K.V.1    Fadl, A.A.2    Tammali, R.3    Reddy, A.B.4    Chopra, A.K.5    Srivastava, S.K.6
  • 89
    • 33745075833 scopus 로고    scopus 로고
    • Oxidative stress and septic shock: Metabolic aspects of oxygen-derived free radicals generated in the liver during endotoxemia
    • Sakaguchi S, Furusawa S. Oxidative stress and septic shock: metabolic aspects of oxygen-derived free radicals generated in the liver during endotoxemia. FEMS Immunol Med Microbiol 2006; 47: 167-77.
    • (2006) FEMS Immunol Med Microbiol , vol.47 , pp. 167-177
    • Sakaguchi, S.1    Furusawa, S.2
  • 90
    • 33847147251 scopus 로고    scopus 로고
    • Mediation of aldose reductase in lipopolysaccharide-induced inflammatory signals in mouse peritoneal macrophages
    • Ramana KV, Srivastava SK. Mediation of aldose reductase in lipopolysaccharide-induced inflammatory signals in mouse peritoneal macrophages. Cytokine 2006; 36: 115-22.
    • (2006) Cytokine , vol.36 , pp. 115-122
    • Ramana, K.V.1    Srivastava, S.K.2
  • 92
    • 70350023106 scopus 로고    scopus 로고
    • Anti-inflammatory effect of aldose reductase inhibition in murine polymicrobial sepsis
    • Reddy AB, Srivastava SK, Ramana KV. Anti-inflammatory effect of aldose reductase inhibition in murine polymicrobial sepsis. Cytokine 2009; 48: 170-6.
    • (2009) Cytokine , vol.48 , pp. 170-176
    • Reddy, A.B.1    Srivastava, S.K.2    Ramana, K.V.3
  • 94
    • 77953295635 scopus 로고    scopus 로고
    • Recent advances in the pathophysiology of asthma
    • Murphy DM, O'Byrne PM. Recent advances in the pathophysiology of asthma. Chest 2010; 137: 1417-26.
    • (2010) Chest , vol.137 , pp. 1417-1426
    • Murphy, D.M.1    O'Byrne, P.M.2
  • 95
    • 70449719352 scopus 로고    scopus 로고
    • Aldose reductase inhibition suppresses the expression of Th2 cytokines and airway inflammation in ovalbumin-induced asthma in mice
    • Yadav UC, Naura AS, Aguilera-Aguirre L, Ramana KV, Boldogh I, Sur S, Boulares HA, Srivastava SK. Aldose reductase inhibition suppresses the expression of Th2 cytokines and airway inflammation in ovalbumin-induced asthma in mice. J Immunol 2009; 183: 4723-32.
    • (2009) J Immunol , vol.183 , pp. 4723-4732
    • Yadav, U.C.1    Naura, A.S.2    Aguilera-Aguirre, L.3    Ramana, K.V.4    Boldogh, I.5    Sur, S.6    Boulares, H.A.7    Srivastava, S.K.8
  • 97
    • 77649136736 scopus 로고    scopus 로고
    • Aldose reductase inhibition for the treatment of asthma
    • Srivastava SK, Ramana KV. Aldose reductase inhibition for the treatment of asthma. Expert Rev Clin Immunol 2010; 6: 1-4.
    • (2010) Expert Rev Clin Immunol , vol.6 , pp. 1-4
    • Srivastava, S.K.1    Ramana, K.V.2
  • 98
    • 77954141742 scopus 로고    scopus 로고
    • Uveitis: Mechanisms and recent advances in therapy
    • Srivastava A, Rajappa M, Kaur J. Uveitis: mechanisms and recent advances in therapy. Clin Chim Acta 2010; 411: 1165-71.
    • (2010) Clin Chim Acta , vol.411 , pp. 1165-1171
    • Srivastava, A.1    Rajappa, M.2    Kaur, J.3
  • 99
    • 35748969896 scopus 로고    scopus 로고
    • Aldose reductase inhibition prevents endotoxin-induced uveitis in rats
    • Yadav UC, Srivastava SK, Ramana KV. Aldose reductase inhibition prevents endotoxin-induced uveitis in rats. Invest Ophthalmol Vis Sci 2007; 48: 4634-42.
    • (2007) Invest Ophthalmol Vis Sci , vol.48 , pp. 4634-4642
    • Yadav, U.C.1    Srivastava, S.K.2    Ramana, K.V.3
  • 100
    • 65549085743 scopus 로고    scopus 로고
    • Prevention of endotoxin-induced uveitis in rats by benfotiamine, a lipophilic analogue of vitamin B1
    • Yadav UC, Subramanyam S, Ramana KV. Prevention of endotoxin-induced uveitis in rats by benfotiamine, a lipophilic analogue of vitamin B1. Invest Ophthalmol Vis Sci 2009; 50: 2276-82.
    • (2009) Invest Ophthalmol Vis Sci , vol.50 , pp. 2276-2282
    • Yadav, U.C.1    Subramanyam, S.2    Ramana, K.V.3
  • 102
    • 77957986937 scopus 로고    scopus 로고
    • Understanding the role of aldose reductase in ocular inflammation
    • Yadav UC, Srivastava SK, Ramana KV. Understanding the role of aldose reductase in ocular inflammation. Curr Mol Med 2010; 10: 540-9.
    • (2010) Curr Mol Med , vol.10 , pp. 540-549
    • Yadav, U.C.1    Srivastava, S.K.2    Ramana, K.V.3
  • 104
    • 69249161777 scopus 로고    scopus 로고
    • Colorectal cancer and inflammatory bowel disease: Epidemiology, risk factors, mechanisms of carcinogenesis and prevention strategies
    • Triantafillidis JK, Nasioulas G, Kosmidis PA. Colorectal cancer and inflammatory bowel disease: epidemiology, risk factors, mechanisms of carcinogenesis and prevention strategies. Anticancer Res 2009; 29: 2727-37.
    • (2009) Anticancer Res , vol.29 , pp. 2727-2737
    • Triantafillidis, J.K.1    Nasioulas, G.2    Kosmidis, P.A.3
  • 106
    • 34249732513 scopus 로고    scopus 로고
    • Aldose reductase regulates TNF-α-induced PGE2 production in human colon cancer cells
    • Tammali R, Ramana KV, Srivastava SK. Aldose reductase regulates TNF-α-induced PGE2 production in human colon cancer cells. Cancer Lett 2007; 252: 299-306.
    • (2007) Cancer Lett , vol.252 , pp. 299-306
    • Tammali, R.1    Ramana, K.V.2    Srivastava, S.K.3
  • 107
    • 65549117476 scopus 로고    scopus 로고
    • Aldose reductase deficiency in mice prevents azoxymethane-induced colonic preneoplastic aberrant crypt foci formation
    • Tammali R, Reddy AB, Ramana KV, Petrash JM, Srivastava SK. Aldose reductase deficiency in mice prevents azoxymethane-induced colonic preneoplastic aberrant crypt foci formation. Carcinogenesis 2009; 30: 799-807.
    • (2009) Carcinogenesis , vol.30 , pp. 799-807
    • Tammali, R.1    Reddy, A.B.2    Ramana, K.V.3    Petrash, J.M.4    Srivastava, S.K.5
  • 108
    • 70749089191 scopus 로고    scopus 로고
    • Aldose reductase: A novel therapeutic target for inflammatory pathologies
    • Ramana KV, Srivastava SK. Aldose reductase: a novel therapeutic target for inflammatory pathologies. Int J Biochem Cell Biol 2010; 42: 17-20.
    • (2010) Int J Biochem Cell Biol , vol.42 , pp. 17-20
    • Ramana, K.V.1    Srivastava, S.K.2
  • 109


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.