Zopolrestat prevention of proteinuria, albuminuria and cataractogenesis in diabetes mellitus

Pharmacology

Volumn 52, Issue 5, 1996, Pages 292-302

  Beyer Mears, A ^a   Mistry, K ^a   Diecke, F P J ^a   Cruz, E ^a  

^a INSTITUTE OF OPHTHALMOLOGY AND VISUAL SCIENCE   (United States)

Author keywords

Albumin; Aldose reductase inhibitors; Cataract; Diabetes mellitus; Kidney; Na K ATPase; Proteinuria; Zopolrestat

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ALDOSE REDUCTASE INHIBITOR; GLUCOSE; INOSITOL; SORBITOL; ZOPOLRESTAT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CATARACT; CATARACTOGENESIS; CONTROLLED STUDY; DIABETES MELLITUS; LENS; MALE; MICROALBUMINURIA; NONHUMAN; PRIORITY JOURNAL; PROTEINURIA; RAT; STREPTOZOCIN DIABETES;

EID: 0030015170     PISSN: 00317012     EISSN: 14230313     Source Type: Journal    
DOI: 10.1159/000139394     Document Type: Article

References (37)

1. Kinoshita JH, Kador P, Datiles M: Aldose reductase in diabetic cataracts, J Am Med Assoc 1981;246: 257-261.
2. Williamson JR, Chang K, Tilton RG, Prater C, Jeffrey JR, Weigel C, Sherman WR, Eades DM, Kilo C: Increased vascular permeability in spontaneously diabetic BB/W rats and in rats with mild versus severe slreptozocin-induced diabetes prevention by aldose reductase inhibitors and castration, Diabetes 1987; 36:813-821.
3. Sarges R, Oates PJ: Aldose reductase inhibitors: Recent developments, Prog Drug Res 1993:40:99-161.
4. Wilson DK, Tarie I, Petrash JM, Quiocho FA: Refined 1.8 À structure of human aldose reductase complexed with the potent inhibitor Zopolrcstat, Biochemistry 1993;90: 9847-9851.
5. Amoff SL, Schnider S, Smcltzcr J, Mackay W, Tchou P, Rushforth N, Miller M, Bennett PH: Urinary excretion and renal clearance of specific plasma proteins in diabetes of short and long duration, Diabetes 1981;30:656-663.
6. Mogensen CE, StcfTcs MW, Decker! T, Christiansen JSB: Functional and morphologic renal manifestations in diabetic meilitus, Diabetologia 1981;21:89-93.
7. Mogensen CE, Christensen CK: Predicting diabetic nephropathy in insulin-dependent patients, N Engl J Med 1984:311:89-93.
8. Beycr-Mcars A: The polyol pathway, sorbinil, and renal dysfunction, Metabolism 1986;35(suppl 1):46-54.
9. Beycr-Mcars A, Cruz E, Edclist T, Variagiannis E: Diminished proteinuria in diabetes meilitus by sorbinil, an aldose reductase inhibitor, Pharmacology 1986;32:52-60.
10. Beyer-Mears A, Murray FT, DelVal M, Cruz E, Sciadini M: Reversal of proteinuria by sorbinil, an aldose reductase inhibitor in spontaneously diabetic BB rats, Pharmacology 1988;36:112-120.
11. Beyer-Mears A, Cruz E: Reversal of diabetic cataract by sorbinil, an aldose reductase inhibitor, Diabetes 1985;34:15-21.
12. Pcsce MA, Strande CS: A new micromethod for determination of protein in cerebrospinal fluid and urine, Clin Chem 1973;19:1265-1267.
13. Pennell JP, Meinking TL: Patcm of urinary proteins in experimental diabetes, Kidney Int 1982;21:709-713.
14. Ncphrat N: For the quantitation of rat urinary albumin, Exocell Inc, Philadelphia, Pa, USA.
15. Beycr-Mcars A, Cruz E, Varagiannis E: Reversal of stage-I sugar cataract by sorbinil, an aldose reductase inhibitor, Pharmacology 1985:31: 88-96.
16. Beyer-Mears A, Kelly K, Cruz E: Synergism of sorbinil and normal diet on reversal of stage-il sugar cataract, Pharmacology 1985:31:170-179.
17. Gelehrter TD, Shreve PD, Dilworth WM: Insulin regulation of Na/K pump activity in rate hepatoma cells, Diabetes 1984;33:424-434.
18. Mistry KP, Beyer-Mears A, Diccke FPJ: Mechanisms for D-glucosc inhibition of myoinositol influx into rat lens, Diabetes 1993:42: 1737-1744.
19. Oates PJ, Ellery CA, Goldfarb S: Aldose reductase inhibitor Zopolrcstat reduces hyperfiltration and albuminuria in diabetic rats, Diabctolog-ia 1992;34(suppl 1):A148.
20. Beyer-Mears A, Nicholas-Alexandre J, Cruz E: Sorbinil inhibition of renal aldose reductase, Fed Proc 1982; 41:858.
21. Beycr-Mcars A, Ku L, Cohen M: Glomerular polyol accumulation in diabetes and its prevention by oral sorbinil, Diabetes 1984:33: 604-607.
22. Beyer-Mears A, Murray FT, Cruz E, Rountree J, Sciadini M: Comparison of sorbinil and Ponalrestat (sta-til) diminution of proteinuria in the BB rat, Pharmacology 1992:45: 285-291.
23. Sima AAF, Prashar A, Zhang W, Chakrabarti S, Greene DA: Preventive effect of long-term aldose reductase inhibition (Ponalrestat) on nerve conduction and sural nerve structure in the spontaneously diabetic bio-breeding rat, J Clin Invest 1990;85:1410-1420.
24. Wei-Xian S, Chakrabarti S, Greene DA, Sima AAF: Diabetic autonomic neuropathy in BB rats and effect of AR1 treatment on heart-rate variability and vagus nerve structure, Diabetes 1990;39:613-618.
25. Tilton RG, Chang K, Pugliese G, Eades DM, Province MA, Sherman WR, Kilo C, Williamson JR: Prevention of hemodynamic and vascular albumin nitration changes in diabetic rats by aldose reductase inhibitors, Diabetes 1989;38:1258-1270.
26. Goldfarb S, Simmons DA, Kern EFO: Amelioration of glomerular hyperfiltration in acute experimental diabetes meilitus by dietary myoinositol supplementation and aldose reductase inhibition, Trans Assoc Am Physicians 1986:99:67-72.
27. Bank N, Mower P, Aynedjian HS, Wilkes BM, Silverman S: Sorbinil prevents glomerular hyperperfusion in diabetic rats, Am J Physiol 1989; 256:F1000-F1006.
28. Bank N: Mechanisms of diabetic hyperfiltration, Kidney Int 1991;40: 792-807.
29. Craven PA, DeRubcrtis FR: Sorbin-il suppresses glomerular prostaglandin production in the streptozocin diabetic rat, Metabolism 1989;38: 649-654.
30. Oates PJ: Diabetic nephropathy, renal hemodynamics, and aldose reductase inhibitors, Drug Dev Res 1994:32:104-116.
31. Rudbcrg S, Person B, Dahlquist G: Increased glomerular filtration rate as a predictor of diabetic nephropathy-An 8-year prospective study, Kidney Int 1992;41:822-828.
32. Rudbcrg S, Ullman E, Dahlquist G: Relationship between early metabolic control and the development of microalbuminuria-A longitudinal study in children with type 1 (insulin-dependent) diabetes mellitus, Diabetologia 1993:36:1309-1314.
33. Kikkawa R, Umemura K, Maneda M, Arimura T, Ebata K, Shigeta Y: Evidence for existence of polyol pathway in cultured rat mesangial cells, Diabetes 1987;36:240-243.
34. Stcffes MW, Osterby R, C'havcrs B, Maucr SM: Mesangial expansion as a central mechanism for loss of kidney function in diabetic patients, Diabetes 1989;38:1077-1081.
35. Myers BD, Winetz JA, Chui F, Michaels AS: Mechanism of proteinuria in diabetic nephropathy; A study of glomerular barrier function, Kidney Int 1982;21:633-641.
36. Pedersen MM, Christiansen JS, Mo-gensen CE: Reduction of glomerular hyperfiltration in normoalbuminur-ic IDDM patients by 6 months of aldose reductase inhibition, Diabetes 1991;40:527-531.
37. Passariello N, Sepe J, Marrazzo G, DeCicco A, Peluso A, Pisano MCA, Sgambalo S, Tesauro P, D'Onofrio F: Effect of aldose reductase inhibitor (Tolrestat) on urinary albumin excretion rate and glomerular filtration rale in IDDM subjects with nephropathy, Diabetes Care 1993:16: 789-795.