Curcumin ameliorates diabetic nephropathy by inhibiting the activation of the SphK1-S1P signaling pathway

Molecular and Cellular Endocrinology

Volumn 365, Issue 2, 2013, Pages 231-240

  Huang, Juan ^a   Huang, Kaipeng ^a   Lan, Tian ^b   Xie, Xi ^a   Shen, Xiaoyan ^a   Liu, Peiqing ^a   Huang, Heqing ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b GUANGDONG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

AP 1; Curcumin; Diabetic nephropathy; Sphingosine 1 phosphate; Sphingosine kinase 1

Indexed keywords

CURCUMIN; FIBRONECTIN; MESSENGER RNA; PROTEIN C JUN; SMALL INTERFERING RNA; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE KINASE 1; TRANSCRIPTION FACTOR AP 1; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETIC NEPHROPATHY; DNA BINDING; DOWN REGULATION; DRUG EFFICACY; DRUG MECHANISM; ENZYME ACTIVATION; FIBRONECTIN GENE; GENE; GENE EXPRESSION REGULATION; MALE; MESANGIUM CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RAT; RENAL PROTECTION; SIGNAL TRANSDUCTION; SPHINGOSINE KINASE 1 GENE; TRANSFORMING GROWTH FACTOR BETA1 GENE; UPREGULATION; WILD TYPE;

ANIMALS; ANTIOXIDANTS; CELLS, CULTURED; CURCUMIN; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEPHROPATHIES; DRUG EVALUATION, PRECLINICAL; FIBRONECTINS; GENE EXPRESSION; GLUCOSE; JNK MITOGEN-ACTIVATED PROTEIN KINASES; KIDNEY; LYSOPHOSPHOLIPIDS; MALE; MESANGIAL CELLS; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; SPHINGOSINE; TRANSCRIPTION FACTOR AP-1; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84871364126     PISSN: 03037207     EISSN: 18728057     Source Type: Journal    
DOI: 10.1016/j.mce.2012.10.024     Document Type: Article

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