Effects of NADPH oxidase inhibitor on diabetic nephropathy in OLETF rats: The role of reducing oxidative stress in its protective property

Diabetes Research and Clinical Practice

Volumn 83, Issue 2, 2009, Pages 176-182

  Nam, Soo Min ^a   Lee, Mi Young ^b   Koh, Jang Hyun ^b   Park, Jun Ho ^b   Shin, Jang Yel ^b   Shin, Young Goo ^b   Koh, Sang Baek ^b   Lee, Eun Young ^c   Chung, Choon Hee ^b  

^a Sun General Hospital   (South Korea)

^b Yonsei University Wonju College of Medicine   (South Korea)

^c Soonchunhyang University College of Medicine   (South Korea)

Author keywords

Apocynin; Diabetic nephropathy; NADPH oxidase; Oxidative stress

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; ALBUMIN; APOCYNIN; CREATININE; GLUCOSE; MALONALDEHYDE; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; CREATININE URINE LEVEL; DIABETIC NEPHROPATHY; GLUCOSE BLOOD LEVEL; IMMUNOHISTOCHEMISTRY; KIDNEY HYPERTROPHY; MALE; NONHUMAN; OPTICAL DENSITY; OTSUKA LONG EVANS TOKUSHIMA FATTY RAT; OXIDATIVE STRESS; PROTEIN EXPRESSION; PROTEIN SECRETION; PROTEIN URINE LEVEL; RAT; REAL TIME POLYMERASE CHAIN REACTION; RENAL PROTECTION; TREATMENT OUTCOME;

ACETOPHENONES; ANIMALS; CYTOPROTECTION; DEOXYGUANOSINE; DIABETES MELLITUS, TYPE 2; DIABETIC NEPHROPATHIES; DOWN-REGULATION; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; HYPOGLYCEMIC AGENTS; KIDNEY; MALE; MALONDIALDEHYDE; NADPH OXIDASE; OXIDATIVE STRESS; RATS; RATS, INBRED OLETF; RATS, LONG-EVANS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 58249119832     PISSN: 01688227     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.diabres.2008.10.007     Document Type: Article

References (37)

1. Cooper M.E. Interaction of metabolic and haemodynamic factors in mediating experimental diabetic nephropathy. Diabetologia 44 (2001) 1957-1972
2. Baynes J.W. Role of oxidative stress in development of complications in diabetes. Diabetes 40 (1991) 405-412
3. Makino H., Shikata K., Hironaka K., Kushiro M., Yamasaki Y., Sugimoto H., et al. Ultrastructure of nonenzymatically glycated mesangial matrix in diabetic nephropathy. Kidney Int. 48 (1995) 517-526
4. Studer R., Craven P., and DeRubertis F. Antioxidant inhibition of protein kinase C-signaled increases in transforming growth factor-beta in mesangial cells. Metabolism 46 (1997) 918-925
5. Park S., Choi H., Lee J., Woo C., Kim J., and Han H. High glucose inhibits renal proximal tubule cell proliferation and involves PKC, oxidative stress, and TGF-beta 1. Kidney Int. 59 (2001) 1695-1705
6. Ohshiro Y., and Takasu N. Molecular mechanism of diabetic nephropathy. Nippon Rinsho 64 (2006) 997-1003
7. Asaba K., Tojo A., Onozato M.L., Goto A., Quinn M., Fujita T., et al. Effects of NADPH oxidase inhibitor in diabetic nephropathy. Kidney Int. 67 (2005) 1890-1898
8. phox containing NADPH oxidase selectively expressed in endothelial cells is a major source of oxygen radical generation in the arterial wall. Circ. Res. 87 (2000) 26-32
9. Ebrahimian T.G., Heymes C., You D., Blanc-Brude O., Mees B., Waeckel L., et al. NADPH oxidase-derived overproduction of reactive oxygen species impairs postischemic neovascularization in mice with type 1 diabetes. Am. J. Pathol. 169 (2006) 719-728
10. Hart B.A., and Simons J.M. Metabolic activation of phenols by stimulated neutrophils: a concept for a selective type of anti-inflammatory drug. Biotechnol. Ther. 3 (1992) 119-135
11. Meyer J.W., and Schmitt M.E. A central role for the endothelial NADPH oxidase in atherosclerosis. FEBS Lett. 472 (2000) 1-4
12. Weibel E.R., and Gomez D.M. A principle for counting tissue structures on random sections. J. Appl. Physiol. 17 (1962) 343-348
13. Saito T., Sumithran E., Glasgow E.F., and Atkins R.C. The enhancement of aminonucleoside nephrosis by the co-administration of protamine. Kidney Int. 32 (1987) 691-699
14. Tojo A., Kimura K., Nanba S., Matsuoka H., and Sugimoto T. Variations in renal arteriolar diameter in deoxycorticosterone acetate-salt hypertensive rats, a microvascular cast study. Virchows Arch. Pathol. Anat. Histopathol. 417 (1990) 389-393
15. Chomczynski P., and Sacchi N. Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162 (1987) 156-160
16. Liu J., Yeo H.C., Doniger S.J., and Ames B.N. Product differentiation by analysis of DNA melting curves during the polymerase chain reaction. Anal. Biochem. 245 (1997) 161-166
17. Pilger A., Germadnik D., Schaffer A., Theiler A., Pils P., Sluka F., et al. 8-Hydroxydeoxyguanosine in leukocyte DNA and urine of quartz-exposed workers and patients with silicosis. Int. Arch. Occup. Environ. Health 73 (2000) 305
18. Pilger A., Invancsits S., Germadnik D., and Rudigr H.W. Urinary excretion of 8-hydroxy-2′-deoxyguanosine measured by HPLC with electrochemical detection. J. Chromatogr. B. 778 (2002) 393-401
19. Korchazhkina O., Christopher E., and Stephen A.S. Measurement by revered-phase HPLC of malondialdehyde in normal human urine following derivatisation with 2,4-dinitrophenylhydrazine. J. Chromatogr. B 794 (2003) 353-362
20. Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature 414 (2001) 813-820
21. Hancock J.T., Desikan R., and Neill S.J. Role of reactive oxygen species in cell signalling pathways. Biochem. Soc. Trans. 29 (2001) 345-350
22. Gill P.S., and Wilcox C.S. NADPH oxidases in the kidney. Antioxid. Redox. Signal 8 (2006) 1597-1607
23. Bonizzi G., Piette J., Schoonbroodt S., Greimers R., Havard L., Merville M.P., et al. Reactive oxygen intermediate-dependent NF-kappaB activation by interleukin-1beta requires 5-lipoxygenase or NADPH oxidase activity. Mol. Cell. Biol. 19 (1999) 1950-1960
24. phox-based NADH oxidase in vascular smooth muscle. Biochem. J. 329 (1998) 653-657
25. Jaimes E.A., Galceran J.M., and Raij L. Angiotensin II induces superoxide anion production by mesangial cells. Kidney Int. 54 (1998) 775-784
26. Liu B.C., Huang H.Q., Luo D.D., Ma K.L., Liu D.G., and Liu H. Connective tissue growth factor is associated with the early renal hypertrophy in uninephrectomized diabetic rats. Chin. Med. J. 20 (2006) 1010-1016
27. Osterby R., Gundersen H.J., Nyberg G., and Aurell M. Advanced diabetic glomerulopathy. Quantitative structural characterization of nonoccluded glomeruli. Diabetes 36 (1987) 612-619
28. Ferrara N. Role of vascular endothelial growth factor in the regulation of angiogenesis. Kidney Int. 56 (1999) 794-814
29. Lee M.Y., Lee E.Y., Lee B.J., Won C.S., Koh J.H., Shin J.Y., et al. Beneficial effects of thiazolidinediones on diabetic nephropathy in OLETF rats. Yonsei Med. J. 48 (2007) 301-307
30. Dvorak H.F., Brown L.F., Detmar M., and Dvorak A.M. Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. Am. J. Pathol. 146 (1995) 1029-1039
31. Clauss M., Gerlach M., Gerlach H., Brett J., Wang F., Familletti P.C., et al. Vascular permeability factor: a tumor-derived polypeptide that induces endothelial cell and monocyte procoagulant activity, and promotes monocyte migration. J. Exp. Med. 172 (1990) 1535-1545
32. Cha D.R., Kang Y.S., Han S.Y., Jee Y.J., Han K.H., Han J.Y., et al. Vascular endothelial growth factor is increased during early stage of diabetic nephropathy in type II diabetic rats. J. Endocrinol. 183 (2004) 183-194
33. Bastian N.R., and Hibbs Jr. J.B. Assembly and regulation of NADPH oxidase and nitric oxide synthase. Curr. Opin. Immunol. 6 (1994) 131-139
34. Abid M.R., Schoots I.G., Spokes K.C., Wu S.Q., Mawhinney C., and Aird W.C. Vascular endothelial growth factor-mediated induction of manganese superoxide dismutase occurs through redox-dependent regulation of forkhead and IkappaB/NF-kappaB. J. Biol. Chem. 279 (2004) 44030-44038
35. Xia L., Wang H., Munk S., Frecker H., Goldberg H.J., Fantus I.G., et al. Reactive oxygen species, PKC-{beta}1, and PKC-{zeta} mediate high glucose-induced vascular endothelial growth factor expression in mesangial cells. Am. J. Physiol. Endocrinol. Metab. (2007) E1280-E1288
36. Li L., and Renier G. Activation of nicotinamide adenine dinucleotide phosphate (reduced form) oxidase by advanced glycation end products links oxidative stress to altered retinal vascular endothelial growth factor expression. Metabolism 55 (2006) 1516-1523
37. Lee E.Y., Chung C.H., Kim J.H., Kim J.H., Joung H.J., and Hong S.Y. Antioxidants ameliorate the expression of vascular endothelial growth factor mediated by protein kinase C in diabetic podocytes. Nephrol. Dial. Transplant. 21 (2006) 1496-1503