Fluorofenidone attenuates collagen i and transforming growth factor-β1 expression through a nicotinamide adenine dinucleotide phosphate oxidase-dependent way in NRK-52E cells

Nephrology

Volumn 14, Issue 6, 2009, Pages 565-572

  Peng, Zhang Zhe ^a   Hu, Gao Yun ^b   Shen, Hong ^b   Wang, Ling ^a   Ning, Wang Bin ^a   Xie, Yan Yun ^a   Wang, Na Sui ^a   Li, Bing Xin ^a   Tang, Yi Ting ^a   Tao, Li Jian ^a,b  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Fluorofenidone; Nicotinamide adenine dinucleotide phosphate oxidase; Reactive oxygen species; Renal interstitial fibrosis; Transforming growth factor 1

Indexed keywords

ANGIOTENSIN II; COLLAGEN TYPE 1; DIPHENYLIODONIUM SALT; FLUOROFENIDONE; LOSARTAN; MESSENGER RNA; PIRFENIDONE; PYRIDONE DERIVATIVE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; EPITHELIUM CELL; KIDNEY FIBROSIS; KIDNEY PROXIMAL TUBULE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; RAT;

ANIMALS; CELLS, CULTURED; COLLAGEN TYPE I; FIBROSIS; KIDNEY; KIDNEY TUBULES, PROXIMAL; NADPH OXIDASE; PYRIDONES; RATS; SUPEROXIDES; TRANSFORMING GROWTH FACTOR BETA1;

EID: 69549110735     PISSN: 13205358     EISSN: 14401797     Source Type: Journal    
DOI: 10.1111/j.1440-1797.2009.01129.x     Document Type: Article

References (34)

1. Lassegue B, Clempus RE. Vascular NAD(P)H oxidases: Specific features, expression, and regulation. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2003 285 : R277 97.
2. Lodha S, Dani D, Mehta R et al. Angiotensin II-induced mesangial cell apoptosis: Role of oxidative stress. Mol. Med. 2002 8 : 830 840.
3. Feliers D, Gorin Y, Ghosh-Choudhury G et al. Angiotensin II stimulation of VEGF mRNA translation requires production of reactive oxygen species. Am. J. Physiol. Renal Physiol. 2006 290 : F927 36.
4. Hanna IR, Taniyama Y, Szocs K et al. NAD(P)H oxidase-derived reactive oxygen species as mediators of angiotensin II signaling. Antioxid. Redox Signal. 2002 4 : 899 914.
5. Tojo A, Asaba K, Onozato ML. Suppressing renal NADPH oxidase to treat diabetic nephropathy. Expert Opin. Ther. Targets 2007 11 : 1011 1018.
6. Nakayama S, Mukae H, Sakamoto N et al. Pirfenidone inhibits the expression of HSP47 in TGF-beta1-stimulated human lung fibroblasts. Life Sci. 2008 82 : 210 217.
7. Van Erp C, Irwin NG, Hoey AJ. Long-term administration of pirfenidone improves cardiac function in mdx mice. Muscle Nerve 2006 34 : 327 334.
8. Cho ME, Smith DC, Branton MH et al. Pirfenidone slows renal function decline in patients with focal segmental glomerulosclerosis. Clin. J. Am. Soc. Nephrol. 2007 2 : 906 913.
9. Di Sario A, Bendia E, Macarri G et al. The anti-fibrotic effect of pirfenidone in rat liver fibrosis is mediated by downregulation of procollagen alpha1(I), TIMP-1 and MMP-2. Dig. Liver Dis. 2004 36 : 744 751.
10. Cao W, He L, Liu W et al. Determination of AKF-PD in whole blood of rat by HPLC-UV. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2006 833 : 257 259.
11. Tao LJ, Zhang J, Hu GY Effects of 1-(3-fluorophenyl)-5-methyl-2-(1H)- pyridone on renal fibroblast in rats Zhong Nan Da Xue Xue Bao Yi Xue Ban 2004 29 : 139 141 In Chinese H, Huang G, Hadi M et al. Transforming growth factor-beta1 downregulation of Smad1 gene expression in rat hepatic stellate cells. Am. J. Physiol. Gastrointest. Liver Physiol. 2003 285 : G539 46.
12. Winer J, Jung CK, Shackel I et al. Development and validation of real-time quantitative reverse transcriptase-polymerase chain reaction for monitoring gene expression in cardiac myocytes in vitro. Anal. Biochem. 1999 270 : 41 9.
13. Shen H, Fan Y, Yang X et al. Increased expression of cystic fibrosis transmembrane conductance regulator in rat liver after common bile duct ligation. J. Cell Physiol. 2005 203 : 599 603.
14. Shi Y, Niculescu R, Wang D et al. Increased NAD(P)H oxidase and reactive oxygen species in coronary arteries after balloon injury. Arterioscler. Thromb. Vasc. Biol. 2001 21 : 739 745.
15. Ha H, Lee HB. Reactive oxygen species amplify glucose signalling in renal cells cultured under high glucose and in diabetic kidney. Nephrology (Carlton) 2005 10 (Suppl S7 10.
16. Rhyu DY, Yang Y, Ha H et al. Role of reactive oxygen species in TGF-beta1-induced mitogen-activated protein kinase activation and epithelial-mesenchymal transition in renal tubular epithelial cells. J. Am. Soc. Nephrol. 2005 16 : 667 675.
17. Poli G, Parola M. Oxidative damage and fibrogenesis. Free Radic. Biol. Med. 1997 22 : 287 305.
18. Shiose A, Kuroda J, Tsuruya K et al. A novel superoxide-producing NAD(P)H oxidase in kidney. J. Biol. Chem. 2001 276 : 1417 1423.
19. Xia L, Wang H, Goldberg HJ et al. Mesangial cell NADPH oxidase upregulation in high glucose is protein kinase C dependent and required for collagen IV expression. Am. J. Physiol. Renal Physiol. 2006 290 : F345 56.
20. Xia L, Wang H, Munk S et al. High glucose activates PKC-zeta and NADPH oxidase through autocrine TGF-beta1 signaling in mesangial cells. Am. J. Physiol. Renal Physiol. 2008 295 : F1705 14.
21. Liu H, Drew P, Cheng Y et al. Pirfenidone inhibits inflammatory responses and ameliorates allograft injury in a rat lung transplant model. J. Thorac. Cardiovasc. Surg. 2005 130 : 852 858.
22. Salazar-Montes A, Ruiz-Corro L, Lopez-Reyes A et al. Potent antioxidant role of Pirfenidone in experimental cirrhosis. Eur. J. Pharmacol. 2008 595 : 69 77.
23. Misra HP, Rabideau C. Pirfenidone inhibits NADPH-dependent microsomal lipid peroxidation and scavenges hydroxyl radicals. Mol. Cell Biochem. 2000 204 : 119 126.
24. Mitani Y, Sato K, Muramoto Y et al. Superoxide scavenging activity of pirfenidone-iron complex. Biochem. Biophys. Res. Commun. 2008 372 : 19 23.
25. Wolf G. Role of reactive oxygen species in angiotensin II-mediated renal growth, differentiation, and apoptosis. Antioxid. Redox Signal. 2005 7 : 1337 1345.
26. Ohtsu H, Frank GD, Utsunomiya H et al. Redox-dependent protein kinase regulation by angiotensin II: Mechanistic insights and its pathophysiology. Antioxid. Redox Signal. 2005 7 : 1315 1326.
27. Touyz RM. Reactive oxygen species as mediators of calcium signaling by angiotensin II: Implications in vascular physiology and pathophysiology. Antioxid. Redox Signal. 2005 7 : 1302 1314.
28. El Bekay R, Alvarez M, Monteseirin J et al. Oxidative stress is a critical mediator of the angiotensin II signal in human neutrophils: Involvement of mitogen-activated protein kinase, calcineurin, and the transcription factor NF-kappaB. Blood 2003 102 : 662 671.
29. Sugiyama H, Kobayashi M, Wang DH et al. Telmisartan inhibits both oxidative stress and renal fibrosis after unilateral ureteral obstruction in acatalasemic mice. Nephrol. Dial. Transplant. 2005 20 : 2670 2680.
30. Ruiz-Ortega M, Ruperez M, Esteban V et al. Molecular mechanisms of angiotensin II-induced vascular injury. Curr. Hypertens. Rep. 2003 5 : 73 9.
31. Nakao N, Yoshimura A, Morita H et al. Combination treatment of angiotensin-II receptor blocker and angiotensin-converting-enzyme inhibitor in non-diabetic renal disease (COOPERATE): A randomised controlled trial. Lancet 2003 361 : 117 124. (Pubitemid 36092015)
32. Yavuz D, Kucukkaya B, Haklar G et al. Effects of captopril and losartan on lipid peroxidation, protein oxidation and nitric oxide release in diabetic rat kidney. Prostaglandins Leukot. Essent. Fatty Acids 2003 69 : 223 227.
33. Chu KY, Leung PS. Angiotensin II Type 1 receptor antagonism mediates uncoupling protein 2-driven oxidative stress and ameliorates pancreatic islet beta-cell function in young Type 2 diabetic mice. Antioxid. Redox Signal. 2007 9 : 869 878.
34. Satoh M, Kashihara N, Yamasaki Y et al. Renal interstitial fibrosis is reduced in angiotensin II type 1a receptor-deficient mice. J. Am. Soc. Nephrol. 2001 12 : 317 325.