메뉴 건너뛰기




Volumn 17, Issue 2, 2012, Pages 1373-1387

Design, synthesis and anti-fibrosis activity study of N 1- substituted phenylhydroquinolinone derivatives

Author keywords

Anti fibrosis; N 1 substituted phenylhydroquinolinones; Synthesis

Indexed keywords

QUINOLONE DERIVATIVE;

EID: 84863127185     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules17021373     Document Type: Article
Times cited : (12)

References (20)
  • 2
    • 81255157548 scopus 로고    scopus 로고
    • Relaxin regulates myofibroblast contractility and protects against lung fibrosis
    • Huang, X.; Gai, Y.; Yang, N.; Lu, B.; Samuel, C.S.; Thannickal, V.J.; Zhou, Y. Relaxin regulates myofibroblast contractility and protects against lung fibrosis. Am. J. Pathol. 2011, 179, 2751-2765.
    • (2011) Am. J. Pathol. , vol.179 , pp. 2751-2765
    • Huang, X.1    Gai, Y.2    Yang, N.3    Lu, B.4    Samuel, C.S.5    Thannickal, V.J.6    Zhou, Y.7
  • 3
    • 0028109801 scopus 로고
    • Transforming growth factor β in tissue fibrosis
    • DOI 10.1056/NEJM199411103311907
    • Border, W.A.; Noble, N.A. Transforming growth factor beta in tissue fibrosis. N. Engl. J. Med. 1994, 331, 1286-1292. (Pubitemid 24333194)
    • (1994) New England Journal of Medicine , vol.331 , Issue.19 , pp. 1286-1292
    • Border, W.A.1    Noble, N.A.2
  • 4
    • 34247179606 scopus 로고    scopus 로고
    • The inflammation-fibrosis link? A Jekyll and Hyde role for blood cells during wound repair
    • DOI 10.1038/sj.jid.5700811, PII 5700811
    • Stramer, B.M.; Mori, R.; Martin, P. The inflammation-fibrosis link? A Jekyll and Hyde role for blood cells during wound repair. J. Invest. Dermatol. 2007, 127, 1009-1017. (Pubitemid 46625163)
    • (2007) Journal of Investigative Dermatology , vol.127 , Issue.5 , pp. 1009-1017
    • Stramer, B.M.1    Mori, R.2    Martin, P.3
  • 7
    • 42949163491 scopus 로고    scopus 로고
    • Mechanisms of Hepatic Fibrogenesis
    • DOI 10.1053/j.gastro.2008.03.003, PII S0016508508004290
    • Friedman, S.L. Mechanisms of hepatic fibrogenesis. Gastroenterology 2008, 134, 1655-1669. (Pubitemid 351615417)
    • (2008) Gastroenterology , vol.134 , Issue.6 , pp. 1655-1669
    • Friedman, S.L.1
  • 8
    • 77953352008 scopus 로고    scopus 로고
    • Mediators leading to fibrosis - How to measure and control them in tissue engineering
    • Mu, X.; Bellayr, I.; Walters, T.; Li, Y. Mediators leading to fibrosis - How to measure and control them in tissue engineering. Oper. Tech. Orthop. 2010, 20, 110-118.
    • (2010) Oper. Tech. Orthop. , vol.20 , pp. 110-118
    • Mu, X.1    Bellayr, I.2    Walters, T.3    Li, Y.4
  • 9
    • 79960112806 scopus 로고    scopus 로고
    • Angiotensin II as a morphogenic cytokine stimulating renal fibrogenesis
    • Ruster, C.; Wolf, G. Angiotensin II as a morphogenic cytokine stimulating renal fibrogenesis. J. Am. Soc. Nephrol. 2011, 22, 1189-1199.
    • (2011) J. Am. Soc. Nephrol. , vol.22 , pp. 1189-1199
    • Ruster, C.1    Wolf, G.2
  • 10
    • 79961105470 scopus 로고    scopus 로고
    • P38 kinase inhibitor approved for idiopathic pulmonary fibrosis
    • Moran, N. p38 kinase inhibitor approved for idiopathic pulmonary fibrosis. Nat. Biotechnol. 2011, 29, 301.
    • (2011) Nat. Biotechnol. , vol.29 , pp. 301
    • Moran, N.1
  • 11
    • 38549159026 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of fibrosis
    • DOI 10.1002/path.2277
    • Wynn, T.A. Cellular and molecular mechanisms of fibrosis. J. Pathol. 2008, 214, 199-210. (Pubitemid 351160157)
    • (2008) Journal of Pathology , vol.214 , Issue.2 , pp. 199-210
    • Wynn, T.A.1
  • 13
    • 41149162536 scopus 로고    scopus 로고
    • Effects of three anti-TNF-alpha drugs: Etanercept, infliximab and pirfenidone on release of TNF-alpha in medium and TNF-alpha associated with the cell in vitro
    • Grattendick, K.J.; Nakashima, J.M.; Feng, L.; Giri, S.N.; Margolin, S.B. Effects of three anti-TNF-alpha drugs: etanercept, infliximab and pirfenidone on release of TNF-alpha in medium and TNF-alpha associated with the cell in vitro. Int. Immunopharmacol. 2008, 8, 679-687.
    • (2008) Int. Immunopharmacol. , vol.8 , pp. 679-687
    • Grattendick, K.J.1    Nakashima, J.M.2    Feng, L.3    Giri, S.N.4    Margolin, S.B.5
  • 16
    • 79960660939 scopus 로고    scopus 로고
    • Fluorofenidone attenuates tubulointerstitial fibrosis by inhibiting TGF-beta(1)-induced fibroblast activation
    • Yuan, Q.; Wang, R.; Peng, Y.; Fu, X.; Wang, W.; Wang, L.; Zhang, F.; Peng, Z.; Ning, W.; Hu, G.; et al. Fluorofenidone attenuates tubulointerstitial fibrosis by inhibiting TGF-beta(1)-induced fibroblast activation. Am. J. Nephrol. 2011, 34, 181-194.
    • (2011) Am. J. Nephrol. , vol.34 , pp. 181-194
    • Yuan, Q.1    Wang, R.2    Peng, Y.3    Fu, X.4    Wang, W.5    Wang, L.6    Zhang, F.7    Peng, Z.8    Ning, W.9    Hu, G.10
  • 17
    • 0036647071 scopus 로고    scopus 로고
    • Pharmacokinetics and metabolism of a novel antifibrotic drug pirfenidone, in mice following intravenous administration
    • DOI 10.1002/bdd.311
    • Giri, S.N.; Wang, Q.; Xie, Y.; Lango, J.; Morin, D.; Margolin, S.B.; Buckpitt, A.R. Pharmacokinetics and metabolism of a novel antifibrotic drug pirfenidone, in mice following intravenous administration. Biopharm. Drug Dispos. 2002, 23, 203-211. (Pubitemid 34812311)
    • (2002) Biopharmaceutics and Drug Disposition , vol.23 , Issue.5 , pp. 203-211
    • Giri, S.N.1    Wang, Q.2    Xie, Y.3    Lango, J.4    Morin, D.5    Margolin, S.B.6    Buckpitt, A.R.7
  • 18
    • 41549114925 scopus 로고    scopus 로고
    • An efficient synthesis of N1-substituted 2, 5-dioxo-1,2,5,6,7,8- hexahydro-3-quinoline carboxamide via enolate salts
    • Yermolayev, S.A.; Gorobets, N.Y.; Lukinova, E.V.; Shishkin, O.V.; Shishkina, S.V.; Desenko, S.M. An efficient synthesis of N1-substituted 2,5-dioxo-1,2,5,6,7,8-hexahydro-3-quinoline carboxamide via enolate salts. Tetrahedron 2008, 64, 4649-4655.
    • (2008) Tetrahedron , vol.64 , pp. 4649-4655
    • Yermolayev, S.A.1    Gorobets, N.Y.2    Lukinova, E.V.3    Shishkin, O.V.4    Shishkina, S.V.5    Desenko, S.M.6
  • 19
    • 80051693277 scopus 로고    scopus 로고
    • An unexpected directing effect in the asymmetric transfer hydrogenation of alpha,alpha-disubstituted ketones
    • Soni, R.; Collinson, J.M.; Clarkson, G.C.; Wills, M. An unexpected directing effect in the asymmetric transfer hydrogenation of alpha,alpha-disubstituted ketones. Org. Lett. 2011, 13, 4304-4307.
    • (2011) Org. Lett. , vol.13 , pp. 4304-4307
    • Soni, R.1    Collinson, J.M.2    Clarkson, G.C.3    Wills, M.4
  • 20
    • 0000861194 scopus 로고
    • The reduction of 2-indanone oxime to 2-aminoindane. Methods and mechanisms
    • Rosen, W.E.; Green, M.J. The reduction of 2-indanone oxime to 2-aminoindane. Methods and mechanisms. J. Org. Chem. 1963, 28, 2797-2804.
    • (1963) J. Org. Chem. , vol.28 , pp. 2797-2804
    • Rosen, W.E.1    Green, M.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.