Synthesis and structure-activity relationship of 5-substituent-2(1H)- pyridone derivatives as anti-fibrosis agents

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 6, 2012, Pages 2300-2302

  Chen, Jun ^a   Lu, Miao Miao ^b   Liu, Bin ^b   Chen, Zhuo ^a   Li, Qian Bin ^a   Tao, Li Jian ^b   Hu, Gao Yun ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Anti fibrosis; Fluorofenidone; Pyridone; SAR; Synthesis

Indexed keywords

5 CHLORO 2(1H)-PYRIDONE; 5 CHORO PYRIDONE DERIVATIVE; DIPYRONE; FLUOROFENIDONE; PIRFENIDONE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; METABOLIC PARAMETERS; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ANIMALS; CELL SURVIVAL; FIBROSIS; HUMANS; INHIBITORY CONCENTRATION 50; MICE; NIH 3T3 CELLS; PYRIDONES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84862800833     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.01.073     Document Type: Article

References (25)

1. P.A. Ward, and G.W. Hunninghake J. Respir. Crit. Care Med. 157 1998 S123
2. P. Wang, S.Q. Jia, and C.S. Tang Chin. Pharmaco. Bull. 23 2007 1124
3. Y.H. Huang, Y.X. Chen, W.D. Zheng, L.J. Zhang, Z.X. Chen, and X.Z. Wang J. Th. Mil. Med. Un. 33 2011 1353
4. A. Zoubek, O.A. Haas, R. Ladenstein, H. Gadner, and T. Radaszkiewicz Ped. Hematol. Oncol. 3 1986 135
5. Y. Nakamura, S. Kohzaki, N. Suyama, T. Yamaguchi, S. Kohno, and K. Hayashi Brit. J. Rad. 70 1997 956
6. Y.H. Liu, and Z.M. Han Chin. J. Nephrol. 26 2010 932
7. K.A. Aziz, K.J. Till, H.J. Chen, J.R. Slupsky, F. Campbell, J.C. Cawley, and M. Zuzel Blood 102 2003 1051
8. D.S. Wang, Y. Kou, C.G. Wang, Y. Lu, M. Liu, and H.Y. Liu China Trop. Med. 11 2011 581
9. S.K. Parapuram, S.W. Xu, C. Elliott, I.D. Welch, H. Jones, M. Baron, C.P. Denton, D.J. Abraham, and A. Leask J. Invest. Dermatol. 131 2011 1996
10. J.C. Dussaul, and C. Chatziantoniou Cell Death Diff. 14 2007 1343
11. Shionog, and Intermuer Nat. Rev. Drug Disc. 7 2008 966
12. J. Lasky IDrugs 7 2004 166
13. Tao, L. J.; Hu, G. Y.; Tan, G. S. CN patent 1386737A 2002.
14. L.J. Tao, J. Zhang, and G.Y. Hu J. Cent. S. Un. (Med. Ed.) 29 2004 139
15. A.-M.L. Stevo Mirkovic, and A.F. Seymour J. Pharmacol. 135 2002 961
16. S.N. Iyer, S.B. Margolin, and D.M. Hyde Exp. Lung. Res. 24 1998 119
17. Wu, J.H. Ph.D. Thesis, Shanghai Institute of Metallurgy Materials Physics and Chemistry, July 2000.
18. Liu, Z.; Cheng, Z.N. Presented at 9th National Drug and chemical metabolism of foreign academic conferences, October 2009; Paper 174.
19. C.H. Liu, Y.Y. Hu, X.L. Wang, P. Liu, and L.M. Xu World J. Gastroenterol. 6 2000 361
20. T. Stephen, Wroblesk, and M.D. Arthur Curr. Top. Med. Chem. 5 2005 1005
21. L.S. Adrian, F.D. Frenel, A.P. Nick, H. Qi, K.P. Jeffrey, M.D. Elizabeth, N. Thomas, L.K. Joseph, A.W. Douglas, F.E. Linda, R.L. Matthew, J.R. Mark, B. Carol, F. Manory, H. Kristen, L. Quynh, B. Pedro, and C. Josette J. Med. Chem. 52 2009 6189
22. J.F. Kevin, T.K. Jeffrey, C.G. Agustin, A. Chad, H. Van, A. Danette, Dudley, L.C. Wayne, F.B. Christopher, D. Shrilakshmi, S. Shaoyi, N.M. Samarendra, R.J. Mohamad, and J.E. Jeremy Tetrahedron Lett. 47 2006 7677
23. S.A. Mahood, and P.V.L. Schaffner Org. Synth. 1943 11
24. H.B. Yao, M.L. Wang, Y.C. Zhang, and D.Y. Hang Synth. Chem. 11 2003 156
25. K.A. Kolmakov Can. J. Chem. 85 2007 1070