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Volumn 3, Issue , 2014, Pages e196-

De-repressing LncRNA-targeted genes to upregulate gene expression: Focus on small molecule therapeutics

Author keywords

Cancer; Cardiovascular disease; Epigenetics; Gene upregulation; Long intervening RNAs; Long noncoding RNA; Natural antisense transcript; Neurological disorders; Protein RNA interactions; RNA structure

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; LONG UNTRANSLATED RNA; VIRUS VECTOR;

EID: 84925235630     PISSN: None     EISSN: 21622531     Source Type: Journal    
DOI: 10.1038/mtna.2014.45     Document Type: Review
Times cited : (64)

References (136)
  • 1
    • 34250305146 scopus 로고    scopus 로고
    • Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project
    • Birney, E, Stamatoyannopoulos, JA, Dutta, A, Guigó, R, Gingeras, TR, Margulies, EH et al. (2007). Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature 447: 799-816.
    • (2007) Nature , vol.447 , pp. 799-816
    • Birney, E.1    Stamatoyannopoulos, J.A.2    Dutta, A.3    Guigó, R.4    Gingeras, T.R.5    Margulies, E.H.6
  • 2
    • 24644472515 scopus 로고    scopus 로고
    • Antisense transcription in the mammalian transcriptome
    • Katayama, S, Tomaru, Y, Kasukawa, T, Waki, K, Nakanishi, M, Nakamura, M et al.; RIKEN Genome Exploration Research Group; Genome Science Group (Genome Network Project Core Group); FANTOM Consortium. (2005). Antisense transcription in the mammalian transcriptome. Science 309: 1564-1566.
    • (2005) Science , vol.309 , pp. 1564-1566
    • Katayama, S.1    Tomaru, Y.2    Kasukawa, T.3    Waki, K.4    Nakanishi, M.5    Nakamura, M.6
  • 3
    • 24644519490 scopus 로고    scopus 로고
    • The transcriptional landscape of the mammalian genome
    • Carninci, P, Kasukawa, T, Katayama, S, Gough, J, Frith, MC, Maeda, N et al.; FANTOM Consortium; RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group). (2005). The transcriptional landscape of the mammalian genome. Science 309: 1559-1563.
    • (2005) Science , vol.309 , pp. 1559-1563
    • Carninci, P.1    Kasukawa, T.2    Katayama, S.3    Gough, J.4    Frith, M.C.5    Maeda, N.6
  • 6
    • 84865727393 scopus 로고    scopus 로고
    • The GENCODE v7 catalog of human long noncoding RNAs: Analysis of their gene structure, evolution, and expression
    • Derrien, T, Johnson, R, Bussotti, G, Tanzer, A, Djebali, S, Tilgner, H et al. (2012). The GENCODE v7 catalog of human long noncoding RNAs: analysis of their gene structure, evolution, and expression. Genome Res 22: 1775-1789.
    • (2012) Genome Res , vol.22 , pp. 1775-1789
    • Derrien, T.1    Johnson, R.2    Bussotti, G.3    Tanzer, A.4    Djebali, S.5    Tilgner, H.6
  • 7
    • 34250160256 scopus 로고    scopus 로고
    • RNA maps reveal new RNA classes and a possible function for pervasive transcription
    • Kapranov, P, Cheng, J, Dike, S, Nix, DA, Duttagupta, R, Willingham, AT et al. (2007). RNA maps reveal new RNA classes and a possible function for pervasive transcription. Science 316: 1484-1488.
    • (2007) Science , vol.316 , pp. 1484-1488
    • Kapranov, P.1    Cheng, J.2    Dike, S.3    Nix, D.A.4    Duttagupta, R.5    Willingham, A.T.6
  • 8
    • 34250369629 scopus 로고    scopus 로고
    • Prominent use of distal 5' transcription start sites and discovery of a large number of additional exons in ENCODE regions
    • Denoeud, F, Kapranov, P, Ucla, C, Frankish, A, Castelo, R, Drenkow, J et al. (2007). Prominent use of distal 5' transcription start sites and discovery of a large number of additional exons in ENCODE regions. Genome Res 17: 746-759.
    • (2007) Genome Res , vol.17 , pp. 746-759
    • Denoeud, F.1    Kapranov, P.2    Ucla, C.3    Frankish, A.4    Castelo, R.5    Drenkow, J.6
  • 9
    • 77953802392 scopus 로고    scopus 로고
    • A novel family of plasmid-transferred anti-sense ncRNAs
    • Findeiss, S, Schmidtke, C, Stadler, PF and Bonas, U (2010). A novel family of plasmid-transferred anti-sense ncRNAs. RNA Biol 7: 120-124.
    • (2010) RNA Biol , vol.7 , pp. 120-124
    • Findeiss, S.1    Schmidtke, C.2    Stadler, P.F.3    Bonas, U.4
  • 11
    • 2042437650 scopus 로고    scopus 로고
    • Initial sequencing and analysis of the human genome
    • Lander, ES, Linton, LM, Birren, B, Nusbaum, C, Zody, MC, Baldwin, J et al.; International Human Genome Sequencing Consortium. (2001). Initial sequencing and analysis of the human genome. Nature 409: 860-921.
    • (2001) Nature , vol.409 , pp. 860-921
    • Lander, E.S.1    Linton, L.M.2    Birren, B.3    Nusbaum, C.4    Zody, M.C.5    Baldwin, J.6
  • 12
    • 7244245762 scopus 로고    scopus 로고
    • Finishing the euchromatic sequence of the human genome
    • Collins, FS, Lander, ES, Rogers, J, Waterston, RH; The International Human Genome Sequencing Consortium. (2004). Finishing the euchromatic sequence of the human genome. Nature 431: 931-945.
    • (2004) Nature , vol.431 , pp. 931-945
    • Collins, F.S.1    Lander, E.S.2    Rogers, J.3    Waterston, R.H.4
  • 13
    • 1842584883 scopus 로고    scopus 로고
    • RNA regulation: A new genetics?
    • Mattick, JS (2004). RNA regulation: a new genetics? Nat Rev Genet 5: 316-323.
    • (2004) Nat Rev Genet , vol.5 , pp. 316-323
    • Mattick, J.S.1
  • 14
    • 78650292831 scopus 로고    scopus 로고
    • The majority of total nuclear-encoded non-ribosomal RNA in a human cell is 'dark matter' un-annotated RNA
    • Kapranov, P, St Laurent, G, Raz, T, Ozsolak, F, Reynolds, CP, Sorensen, PH et al. (2010). The majority of total nuclear-encoded non-ribosomal RNA in a human cell is 'dark matter' un-annotated RNA. BMC Biol 8: 149.
    • (2010) BMC Biol , vol.8 , pp. 149
    • Kapranov, P.1    St Laurent, G.2    Raz, T.3    Ozsolak, F.4    Reynolds, C.P.5    Sorensen, P.H.6
  • 15
    • 0035966319 scopus 로고    scopus 로고
    • microRNAs: Tiny regulators with great potential
    • Ambros, V (2001). microRNAs: tiny regulators with great potential. Cell 107: 823-826.
    • (2001) Cell , vol.107 , pp. 823-826
    • Ambros, V.1
  • 16
    • 0035942736 scopus 로고    scopus 로고
    • Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
    • Elbashir, SM, Harborth, J, Lendeckel, W, Yalcin, A, Weber, K and Tuschl, T (2001). Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411: 494-498.
    • (2001) Nature , vol.411 , pp. 494-498
    • Elbashir, S.M.1    Harborth, J.2    Lendeckel, W.3    Yalcin, A.4    Weber, K.5    Tuschl, T.6
  • 17
    • 0035859929 scopus 로고    scopus 로고
    • Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems
    • Caplen, NJ, Parrish, S, Imani, F, Fire, A and Morgan, RA (2001). Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems. Proc Natl Acad Sci USA 98: 9742-9747.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 9742-9747
    • Caplen, N.J.1    Parrish, S.2    Imani, F.3    Fire, A.4    Morgan, R.A.5
  • 18
    • 0035955366 scopus 로고    scopus 로고
    • An extensive class of small RNAs in Caenorhabditis elegans
    • Lee, RC and Ambros, V (2001). An extensive class of small RNAs in Caenorhabditis elegans. Science 294: 862-864.
    • (2001) Science , vol.294 , pp. 862-864
    • Lee, R.C.1    Ambros, V.2
  • 19
    • 0035955361 scopus 로고    scopus 로고
    • An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans
    • Lau, NC, Lim, LP, Weinstein, EG and Bartel, DP (2001). An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans. Science 294: 858-862.
    • (2001) Science , vol.294 , pp. 858-862
    • Lau, N.C.1    Lim, L.P.2    Weinstein, E.G.3    Bartel, D.P.4
  • 20
    • 0035955374 scopus 로고    scopus 로고
    • Identification of novel genes coding for small expressed RNAs
    • Lagos-Quintana, M, Rauhut, R, Lendeckel, W and Tuschl, T (2001). Identification of novel genes coding for small expressed RNAs. Science 294: 853-858.
    • (2001) Science , vol.294 , pp. 853-858
    • Lagos-Quintana, M.1    Rauhut, R.2    Lendeckel, W.3    Tuschl, T.4
  • 21
    • 84864315112 scopus 로고    scopus 로고
    • The lncRNA Malat1 is dispensable for mouse development but its transcription plays a cis-regulatory role in the adult
    • Zhang, B, Arun, G, Mao, YS, Lazar, Z, Hung, G, Bhattacharjee, G et al. (2012). The lncRNA Malat1 is dispensable for mouse development but its transcription plays a cis-regulatory role in the adult. Cell Rep 2: 111-123.
    • (2012) Cell Rep , vol.2 , pp. 111-123
    • Zhang, B.1    Arun, G.2    Mao, Y.S.3    Lazar, Z.4    Hung, G.5    Bhattacharjee, G.6
  • 22
    • 84885740857 scopus 로고    scopus 로고
    • Targeted disruption of Hotair leads to homeotic transformation and gene derepression
    • Li, L, Liu, B, Wapinski, OL, Tsai, MC, Qu, K, Zhang, J et al. (2013). Targeted disruption of Hotair leads to homeotic transformation and gene derepression. Cell Rep 5: 3-12.
    • (2013) Cell Rep , vol.5 , pp. 3-12
    • Li, L.1    Liu, B.2    Wapinski, O.L.3    Tsai, M.C.4    Qu, K.5    Zhang, J.6
  • 23
    • 84891757415 scopus 로고    scopus 로고
    • Multiple knockout mouse models reveal lincRNAs are required for life and brain development
    • Sauvageau, M, Goff, LA, Lodato, S, Bonev, B, Groff, AF, Gerhardinger, C et al. (2013). Multiple knockout mouse models reveal lincRNAs are required for life and brain development. Elife 2: e01749.
    • (2013) Elife , vol.2 , pp. e01749
    • Sauvageau, M.1    Goff, L.A.2    Lodato, S.3    Bonev, B.4    Groff, A.F.5    Gerhardinger, C.6
  • 24
    • 77956927823 scopus 로고    scopus 로고
    • The nuclear-retained noncoding RNA MALAT1 regulates alternative splicing by modulating SR splicing factor phosphorylation
    • Tripathi, V, Ellis, JD, Shen, Z, Song, DY, Pan, Q, Watt, AT et al. (2010). The nuclear-retained noncoding RNA MALAT1 regulates alternative splicing by modulating SR splicing factor phosphorylation. Mol Cell 39: 925-938.
    • (2010) Mol Cell , vol.39 , pp. 925-938
    • Tripathi, V.1    Ellis, J.D.2    Shen, Z.3    Song, D.Y.4    Pan, Q.5    Watt, A.T.6
  • 25
    • 77956882723 scopus 로고    scopus 로고
    • A long nuclear-retained non-coding RNA regulates synaptogenesis by modulating gene expression
    • Bernard, D, Prasanth, KV, Tripathi, V, Colasse, S, Nakamura, T, Xuan, Z et al. (2010). A long nuclear-retained non-coding RNA regulates synaptogenesis by modulating gene expression. EMBO J 29: 3082-3093.
    • (2010) EMBO J , vol.29 , pp. 3082-3093
    • Bernard, D.1    Prasanth, K.V.2    Tripathi, V.3    Colasse, S.4    Nakamura, T.5    Xuan, Z.6
  • 26
    • 84864033675 scopus 로고    scopus 로고
    • Malat1 is not an essential component of nuclear speckles in mice
    • Nakagawa, S, Ip, JY, Shioi, G, Tripathi, V, Zong, X, Hirose, T et al. (2012). Malat1 is not an essential component of nuclear speckles in mice. RNA 18: 1487-1499.
    • (2012) RNA , vol.18 , pp. 1487-1499
    • Nakagawa, S.1    Ip, J.Y.2    Shioi, G.3    Tripathi, V.4    Zong, X.5    Hirose, T.6
  • 27
    • 84864047695 scopus 로고    scopus 로고
    • Loss of the abundant nuclear non-coding RNA MALAT1 is compatible with life and development
    • Eissmann, M, Gutschner, T, Hämmerle, M, Günther, S, Caudron-Herger, M, Groß, M et al. (2012). Loss of the abundant nuclear non-coding RNA MALAT1 is compatible with life and development. RNA Biol 9: 1076-1087.
    • (2012) RNA Biol , vol.9 , pp. 1076-1087
    • Eissmann, M.1    Gutschner, T.2    Hämmerle, M.3    Günther, S.4    Caudron-Herger, M.5    Groß, M.6
  • 28
    • 77951638287 scopus 로고    scopus 로고
    • Noncoding RNA gas5 is a growth arrest- and starvation-associated repressor of the glucocorticoid receptor
    • Kino, T, Hurt, DE, Ichijo, T, Nader, N and Chrousos, GP (2010). Noncoding RNA gas5 is a growth arrest- and starvation-associated repressor of the glucocorticoid receptor. Sci Signal 3: ra8.
    • (2010) Sci Signal , vol.3 , pp. ra8
    • Kino, T.1    Hurt, D.E.2    Ichijo, T.3    Nader, N.4    Chrousos, G.P.5
  • 29
    • 84879582903 scopus 로고    scopus 로고
    • Long non-coding RNA GAS5 regulates apoptosis in prostate cancer cell lines
    • Pickard, MR, Mourtada-Maarabouni, M and Williams, GT (2013). Long non-coding RNA GAS5 regulates apoptosis in prostate cancer cell lines. Biochim Biophys Acta 1832: 1613-1623.
    • (2013) Biochim Biophys Acta , vol.1832 , pp. 1613-1623
    • Pickard, M.R.1    Mourtada-Maarabouni, M.2    Williams, G.T.3
  • 31
    • 46749083733 scopus 로고    scopus 로고
    • Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feedforward regulation of beta-secretase
    • Faghihi, MA, Modarresi, F, Khalil, AM, Wood, DE, Sahagan, BG, Morgan, TE et al. (2008). Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feedforward regulation of beta-secretase. Nat Med 14: 723-730.
    • (2008) Nat Med , vol.14 , pp. 723-730
    • Faghihi, M.A.1    Modarresi, F.2    Khalil, A.M.3    Wood, D.E.4    Sahagan, B.G.5    Morgan, T.E.6
  • 32
    • 84897459814 scopus 로고    scopus 로고
    • An atlas of active enhancers across human cell types and tissues
    • Andersson, R, Gebhard, C, Miguel-Escalada, I, Hoof, I, Bornholdt, J, Boyd, M et al.; FANTOM Consortium. (2014). An atlas of active enhancers across human cell types and tissues. Nature 507: 455-461.
    • (2014) Nature , vol.507 , pp. 455-461
    • Andersson, R.1    Gebhard, C.2    Miguel-Escalada, I.3    Hoof, I.4    Bornholdt, J.5    Boyd, M.6
  • 34
    • 80052869283 scopus 로고    scopus 로고
    • lincRNAs act in the circuitry controlling pluripotency and differentiation
    • Guttman, M, Donaghey, J, Carey, BW, Garber, M, Grenier, JK, Munson, G et al. (2011). lincRNAs act in the circuitry controlling pluripotency and differentiation. Nature 477: 295-300.
    • (2011) Nature , vol.477 , pp. 295-300
    • Guttman, M.1    Donaghey, J.2    Carey, B.W.3    Garber, M.4    Grenier, J.K.5    Munson, G.6
  • 35
    • 77954572735 scopus 로고    scopus 로고
    • Long noncoding RNA as modular scaffold of histone modification complexes
    • Tsai, MC, Manor, O, Wan, Y, Mosammaparast, N, Wang, JK, Lan, F et al. (2010). Long noncoding RNA as modular scaffold of histone modification complexes. Science 329: 689-693.
    • (2010) Science , vol.329 , pp. 689-693
    • Tsai, M.C.1    Manor, O.2    Wan, Y.3    Mosammaparast, N.4    Wang, J.K.5    Lan, F.6
  • 36
    • 77955323879 scopus 로고    scopus 로고
    • A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response
    • Huarte, M, Guttman, M, Feldser, D, Garber, M, Koziol, MJ, Kenzelmann-Broz, D et al. (2010). A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response. Cell 142: 409-419.
    • (2010) Cell , vol.142 , pp. 409-419
    • Huarte, M.1    Guttman, M.2    Feldser, D.3    Garber, M.4    Koziol, M.J.5    Kenzelmann-Broz, D.6
  • 37
    • 67650921949 scopus 로고    scopus 로고
    • Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression
    • Khalil, AM, Guttman, M, Huarte, M, Garber, M, Raj, A, Rivea Morales, D et al. (2009). Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression. Proc Natl Acad Sci USA 106: 11667-11672.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 11667-11672
    • Khalil, A.M.1    Guttman, M.2    Huarte, M.3    Garber, M.4    Raj, A.5    Rivea Morales, D.6
  • 39
    • 34250729138 scopus 로고    scopus 로고
    • Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs
    • Rinn, JL, Kertesz, M, Wang, JK, Squazzo, SL, Xu, X, Brugmann, SA et al. (2007). Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs. Cell 129: 1311-1323.
    • (2007) Cell , vol.129 , pp. 1311-1323
    • Rinn, J.L.1    Kertesz, M.2    Wang, J.K.3    Squazzo, S.L.4    Xu, X.5    Brugmann, S.A.6
  • 40
    • 0026456701 scopus 로고
    • The human XIST gene: Analysis of a 17 kb inactive X-specific RNA that contains conserved repeats and is highly localized within the nucleus
    • Brown, CJ, Hendrich, BD, Rupert, JL, Lafrenière, RG, Xing, Y, Lawrence, J et al. (1992). The human XIST gene: analysis of a 17 kb inactive X-specific RNA that contains conserved repeats and is highly localized within the nucleus. Cell 71: 527-542.
    • (1992) Cell , vol.71 , pp. 527-542
    • Brown, C.J.1    Hendrich, B.D.2    Rupert, J.L.3    Lafrenière, R.G.4    Xing, Y.5    Lawrence, J.6
  • 41
    • 55349109963 scopus 로고    scopus 로고
    • Polycomb proteins targeted by a short repeat RNA to the mouse X chromosome
    • Zhao, J, Sun, BK, Erwin, JA, Song, JJ and Lee, JT (2008). Polycomb proteins targeted by a short repeat RNA to the mouse X chromosome. Science 322: 750-756.
    • (2008) Science , vol.322 , pp. 750-756
    • Zhao, J.1    Sun, B.K.2    Erwin, J.A.3    Song, J.J.4    Lee, J.T.5
  • 42
    • 77955757309 scopus 로고    scopus 로고
    • Kcnq1ot1 noncoding RNA mediates transcriptional gene silencing by interacting with Dnmt1
    • Mohammad, F, Mondal, T, Guseva, N, Pandey, GK and Kanduri, C (2010). Kcnq1ot1 noncoding RNA mediates transcriptional gene silencing by interacting with Dnmt1. Development 137: 2493-2499.
    • (2010) Development , vol.137 , pp. 2493-2499
    • Mohammad, F.1    Mondal, T.2    Guseva, N.3    Pandey, G.K.4    Kanduri, C.5
  • 43
    • 54049138948 scopus 로고    scopus 로고
    • Kcnq1ot1 antisense noncoding RNA mediates lineage-specific transcriptional silencing through chromatin-level regulation
    • Pandey, RR, Mondal, T, Mohammad, F, Enroth, S, Redrup, L, Komorowski, J et al. (2008). Kcnq1ot1 antisense noncoding RNA mediates lineage-specific transcriptional silencing through chromatin-level regulation. Mol Cell 32: 232-246.
    • (2008) Mol Cell , vol.32 , pp. 232-246
    • Pandey, R.R.1    Mondal, T.2    Mohammad, F.3    Enroth, S.4    Redrup, L.5    Komorowski, J.6
  • 44
    • 44349115087 scopus 로고    scopus 로고
    • Kcnq1ot1/Lit1 noncoding RNA mediates transcriptional silencing by targeting to the perinucleolar region
    • Mohammad, F, Pandey, RR, Nagano, T, Chakalova, L, Mondal, T, Fraser, P et al. (2008). Kcnq1ot1/Lit1 noncoding RNA mediates transcriptional silencing by targeting to the perinucleolar region. Mol Cell Biol 28: 3713-3728.
    • (2008) Mol Cell Biol , vol.28 , pp. 3713-3728
    • Mohammad, F.1    Pandey, R.R.2    Nagano, T.3    Chakalova, L.4    Mondal, T.5    Fraser, P.6
  • 45
    • 0037075032 scopus 로고    scopus 로고
    • The non-coding Air RNA is required for silencing autosomal imprinted genes
    • Sleutels, F, Zwart, R and Barlow, DP (2002). The non-coding Air RNA is required for silencing autosomal imprinted genes. Nature 415: 810-813.
    • (2002) Nature , vol.415 , pp. 810-813
    • Sleutels, F.1    Zwart, R.2    Barlow, D.P.3
  • 46
    • 56549111129 scopus 로고    scopus 로고
    • The Air noncoding RNA epigenetically silences transcription by targeting G9a to chromatin
    • Nagano, T, Mitchell, JA, Sanz, LA, Pauler, FM, Ferguson-Smith, AC, Feil, R et al. (2008). The Air noncoding RNA epigenetically silences transcription by targeting G9a to chromatin. Science 322: 1717-1720.
    • (2008) Science , vol.322 , pp. 1717-1720
    • Nagano, T.1    Mitchell, J.A.2    Sanz, L.A.3    Pauler, F.M.4    Ferguson-Smith, A.C.5    Feil, R.6
  • 48
    • 84895908120 scopus 로고    scopus 로고
    • The evolution of lncRNA repertoires and expression patterns in tetrapods
    • Necsulea, A, Soumillon, M, Warnefors, M, Liechti, A, Daish, T, Zeller, U et al. (2014). The evolution of lncRNA repertoires and expression patterns in tetrapods. Nature 505: 635-640.
    • (2014) Nature , vol.505 , pp. 635-640
    • Necsulea, A.1    Soumillon, M.2    Warnefors, M.3    Liechti, A.4    Daish, T.5    Zeller, U.6
  • 49
    • 84877575447 scopus 로고    scopus 로고
    • Integration of genome-wide approaches identifies lncRNAs of adult neural stem cells and their progeny in vivo
    • Ramos, AD, Diaz, A, Nellore, A, Delgado, RN, Park, KY, Gonzales-Roybal, G et al. (2013). Integration of genome-wide approaches identifies lncRNAs of adult neural stem cells and their progeny in vivo. Cell Stem Cell 12: 616-628.
    • (2013) Cell Stem Cell , vol.12 , pp. 616-628
    • Ramos, A.D.1    Diaz, A.2    Nellore, A.3    Delgado, R.N.4    Park, K.Y.5    Gonzales-Roybal, G.6
  • 53
    • 77953096072 scopus 로고    scopus 로고
    • Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a
    • Yap, KL, Li, S, Muñoz-Cabello, AM, Raguz, S, Zeng, L, Mujtaba, S et al. (2010). Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a. Mol Cell 38: 662-674.
    • (2010) Mol Cell , vol.38 , pp. 662-674
    • Yap, K.L.1    Li, S.2    Muñoz-Cabello, A.M.3    Raguz, S.4    Zeng, L.5    Mujtaba, S.6
  • 54
    • 84861904178 scopus 로고    scopus 로고
    • Genome regulation by long noncoding RNAs
    • Rinn, JL and Chang, HY (2012). Genome regulation by long noncoding RNAs. Annu Rev Biochem 81: 145-166.
    • (2012) Annu Rev Biochem , vol.81 , pp. 145-166
    • Rinn, J.L.1    Chang, H.Y.2
  • 55
    • 79959306523 scopus 로고    scopus 로고
    • CTCF regulates ataxin-7 expression through promotion of a convergently transcribed, antisense noncoding RNA
    • Sopher, BL, Ladd, PD, Pineda, VV, Libby, RT, Sunkin, SM, Hurley, JB et al. (2011). CTCF regulates ataxin-7 expression through promotion of a convergently transcribed, antisense noncoding RNA. Neuron 70: 1071-1084.
    • (2011) Neuron , vol.70 , pp. 1071-1084
    • Sopher, B.L.1    Ladd, P.D.2    Pineda, V.V.3    Libby, R.T.4    Sunkin, S.M.5    Hurley, J.B.6
  • 56
    • 77951118936 scopus 로고    scopus 로고
    • Long noncoding RNA HOTAIR reprograms chromatin state to promote cancer metastasis
    • Gupta, RA, Shah, N, Wang, KC, Kim, J, Horlings, HM, Wong, DJ et al. (2010). Long noncoding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. Nature 464: 1071-1076.
    • (2010) Nature , vol.464 , pp. 1071-1076
    • Gupta, R.A.1    Shah, N.2    Wang, K.C.3    Kim, J.4    Horlings, H.M.5    Wong, D.J.6
  • 57
    • 84890310189 scopus 로고    scopus 로고
    • Long non-coding RNA HOTAIR is an independent prognostic marker of metastasis in estrogen receptor-positive primary breast cancer
    • Sørensen, KP, Thomassen, M, Tan, Q, Bak, M, Cold, S, Burton, M et al. (2013). Long non-coding RNA HOTAIR is an independent prognostic marker of metastasis in estrogen receptor-positive primary breast cancer. Breast Cancer Res Treat 142: 529-536.
    • (2013) Breast Cancer Res Treat , vol.142 , pp. 529-536
    • Sørensen, K.P.1    Thomassen, M.2    Tan, Q.3    Bak, M.4    Cold, S.5    Burton, M.6
  • 58
    • 84879400916 scopus 로고    scopus 로고
    • Long noncoding RNA HOTAIR is associated with motility, invasion, and metastatic potential of metastatic melanoma
    • Tang, L, Zhang, W, Su, B and Yu, B (2013). Long noncoding RNA HOTAIR is associated with motility, invasion, and metastatic potential of metastatic melanoma. Biomed Res Int 2013: 251098.
    • (2013) Biomed Res Int , vol.2013 , pp. 251098
    • Tang, L.1    Zhang, W.2    Su, B.3    Yu, B.4
  • 59
    • 84886304944 scopus 로고    scopus 로고
    • Upregulation of the long noncoding RNA HOTAIR promotes esophageal squamous cell carcinoma metastasis and poor prognosis
    • Chen, FJ, Sun, M, Li, SQ, Wu, QQ, Ji, L, Liu, ZL et al. (2013). Upregulation of the long noncoding RNA HOTAIR promotes esophageal squamous cell carcinoma metastasis and poor prognosis. Mol Carcinog 52: 908-915.
    • (2013) Mol Carcinog , vol.52 , pp. 908-915
    • Chen, F.J.1    Sun, M.2    Li, S.Q.3    Wu, Q.Q.4    Ji, L.5    Liu, Z.L.6
  • 60
    • 84880371052 scopus 로고    scopus 로고
    • Up-regulation of HOTAIR long non-coding RNA in human gastric adenocarcinoma tissues
    • Hajjari, M, Behmanesh, M, Sadeghizadeh, M and Zeinoddini, M (2013). Up-regulation of HOTAIR long non-coding RNA in human gastric adenocarcinoma tissues. Med Oncol 30: 670.
    • (2013) Med Oncol , vol.30 , pp. 670
    • Hajjari, M.1    Behmanesh, M.2    Sadeghizadeh, M.3    Zeinoddini, M.4
  • 61
    • 84885394539 scopus 로고    scopus 로고
    • Enhanced expression of long non-coding RNA HOTAIR is associated with the development of gastric cancer
    • Endo, H, Shiroki, T, Nakagawa, T, Yokoyama, M, Tamai, K, Yamanami, H et al. (2013). Enhanced expression of long non-coding RNA HOTAIR is associated with the development of gastric cancer. PLoS ONE 8: e77070.
    • (2013) PLoS ONE , vol.8 , pp. e77070
    • Endo, H.1    Shiroki, T.2    Nakagawa, T.3    Yokoyama, M.4    Tamai, K.5    Yamanami, H.6
  • 62
    • 79955836034 scopus 로고    scopus 로고
    • Overexpression of long non-coding RNA HOTAIR predicts tumor recurrence in hepatocellular carcinoma patients following liver transplantation
    • Yang, Z, Zhou, L, Wu, LM, Lai, MC, Xie, HY, Zhang, F et al. (2011). Overexpression of long non-coding RNA HOTAIR predicts tumor recurrence in hepatocellular carcinoma patients following liver transplantation. Ann Surg Oncol 18: 1243-1250.
    • (2011) Ann Surg Oncol , vol.18 , pp. 1243-1250
    • Yang, Z.1    Zhou, L.2    Wu, L.M.3    Lai, M.C.4    Xie, H.Y.5    Zhang, F.6
  • 63
    • 84875890253 scopus 로고    scopus 로고
    • HOTAIR is a negative prognostic factor and exhibits pro-oncogenic activity in pancreatic cancer
    • Kim, K, Jutooru, I, Chadalapaka, G, Johnson, G, Frank, J, Burghardt, R et al. (2013). HOTAIR is a negative prognostic factor and exhibits pro-oncogenic activity in pancreatic cancer. Oncogene 32: 1616-1625.
    • (2013) Oncogene , vol.32 , pp. 1616-1625
    • Kim, K.1    Jutooru, I.2    Chadalapaka, G.3    Johnson, G.4    Frank, J.5    Burghardt, R.6
  • 64
    • 84893749412 scopus 로고    scopus 로고
    • The long non-coding RNA HOTAIR is upregulated in endometrial carcinoma and correlates with poor prognosis
    • He, X, Bao, W, Li, X, Chen, Z, Che, Q, Wang, H et al. (2014). The long non-coding RNA HOTAIR is upregulated in endometrial carcinoma and correlates with poor prognosis. Int J Mol Med 33: 325-332.
    • (2014) Int J Mol Med , vol.33 , pp. 325-332
    • He, X.1    Bao, W.2    Li, X.3    Chen, Z.4    Che, Q.5    Wang, H.6
  • 65
    • 84889607976 scopus 로고    scopus 로고
    • HOTAIR, a prognostic factor in esophageal squamous cell carcinoma, inhibits WIF-1 expression and activates Wnt pathway
    • Ge, XS, Ma, HJ, Zheng, XH, Ruan, HL, Liao, XY, Xue, WQ et al. (2013). HOTAIR, a prognostic factor in esophageal squamous cell carcinoma, inhibits WIF-1 expression and activates Wnt pathway. Cancer Sci 104: 1675-1682.
    • (2013) Cancer Sci , vol.104 , pp. 1675-1682
    • Ge, X.S.1    Ma, H.J.2    Zheng, X.H.3    Ruan, H.L.4    Liao, X.Y.5    Xue, W.Q.6
  • 66
    • 84885919211 scopus 로고    scopus 로고
    • Long non-coding RNA HOTAIR, a driver of malignancy, predicts negative prognosis and exhibits oncogenic activity in oesophageal squamous cell carcinoma
    • Li, X, Wu, Z, Mei, Q, Li, X, Guo, M, Fu, X et al. (2013). Long non-coding RNA HOTAIR, a driver of malignancy, predicts negative prognosis and exhibits oncogenic activity in oesophageal squamous cell carcinoma. Br J Cancer 109: 2266-2278.
    • (2013) Br J Cancer , vol.109 , pp. 2266-2278
    • Li, X.1    Wu, Z.2    Mei, Q.3    Li, X.4    Guo, M.5    Fu, X.6
  • 67
    • 84878132479 scopus 로고    scopus 로고
    • Long noncoding RNA HOTAIR is a prognostic marker for esophageal squamous cell carcinoma progression and survival
    • Lv, XB, Lian, GY, Wang, HR, Song, E, Yao, H and Wang, MH (2013). Long noncoding RNA HOTAIR is a prognostic marker for esophageal squamous cell carcinoma progression and survival. PLoS ONE 8: e63516.
    • (2013) PLoS ONE , vol.8 , pp. e63516
    • Lv, X.B.1    Lian, G.Y.2    Wang, H.R.3    Song, E.4    Yao, H.5    Wang, M.H.6
  • 68
    • 84871290732 scopus 로고    scopus 로고
    • Long intergenic noncoding RNA HOTAIR is overexpressed and regulates PTEN methylation in laryngeal squamous cell carcinoma
    • Li, D, Feng, J, Wu, T, Wang, Y, Sun, Y, Ren, J et al. (2013). Long intergenic noncoding RNA HOTAIR is overexpressed and regulates PTEN methylation in laryngeal squamous cell carcinoma. Am J Pathol 182: 64-70.
    • (2013) Am J Pathol , vol.182 , pp. 64-70
    • Li, D.1    Feng, J.2    Wu, T.3    Wang, Y.4    Sun, Y.5    Ren, J.6
  • 69
    • 34248547495 scopus 로고    scopus 로고
    • Characterization of a germ-line deletion, including the entire INK4/ARF locus, in a melanoma-neural system tumor family: Identification of ANRIL, an antisense noncoding RNA whose expression coclusters with ARF
    • Pasmant, E, Laurendeau, I, Héron, D, Vidaud, M, Vidaud, D and Bièche, I (2007). Characterization of a germ-line deletion, including the entire INK4/ARF locus, in a melanoma-neural system tumor family: identification of ANRIL, an antisense noncoding RNA whose expression coclusters with ARF. Cancer Res 67: 3963-3969.
    • (2007) Cancer Res , vol.67 , pp. 3963-3969
    • Pasmant, E.1    Laurendeau, I.2    Héron, D.3    Vidaud, M.4    Vidaud, D.5    Bièche, I.6
  • 70
    • 38049155825 scopus 로고    scopus 로고
    • Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA
    • Yu, W, Gius, D, Onyango, P, Muldoon-Jacobs, K, Karp, J, Feinberg, AP et al. (2008). Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA. Nature 451: 202-206.
    • (2008) Nature , vol.451 , pp. 202-206
    • Yu, W.1    Gius, D.2    Onyango, P.3    Muldoon-Jacobs, K.4    Karp, J.5    Feinberg, A.P.6
  • 71
    • 79961202865 scopus 로고    scopus 로고
    • Transcriptome sequencing across a prostate cancer cohort identifies PCAT-1, an unannotated lincRNA implicated in disease progression
    • Prensner, JR, Iyer, MK, Balbin, OA, Dhanasekaran, SM, Cao, Q, Brenner, JC et al. (2011). Transcriptome sequencing across a prostate cancer cohort identifies PCAT-1, an unannotated lincRNA implicated in disease progression. Nat Biotechnol 29: 742-749.
    • (2011) Nat Biotechnol , vol.29 , pp. 742-749
    • Prensner, J.R.1    Iyer, M.K.2    Balbin, O.A.3    Dhanasekaran, S.M.4    Cao, Q.5    Brenner, J.C.6
  • 72
    • 84899939074 scopus 로고    scopus 로고
    • Human colorectal cancer-specific CCAT1-L lncRNA regulates long-range chromatin interactions at the MYC locus
    • Xiang, JF, Yin, QF, Chen, T, Zhang, Y, Zhang, XO, Wu, Z et al. (2014). Human colorectal cancer-specific CCAT1-L lncRNA regulates long-range chromatin interactions at the MYC locus. Cell Res 24: 513-531.
    • (2014) Cell Res , vol.24 , pp. 513-531
    • Xiang, J.F.1    Yin, Q.F.2    Chen, T.3    Zhang, Y.4    Zhang, X.O.5    Wu, Z.6
  • 73
    • 84876830254 scopus 로고    scopus 로고
    • Epigenetic upregulation of lncRNAs at 13q14.3 in leukemia is linked to the In Cis downregulation of a gene cluster that targets NF-kB
    • Garding, A, Bhattacharya, N, Claus, R, Ruppel, M, Tschuch, C, Filarsky, K et al. (2013). Epigenetic upregulation of lncRNAs at 13q14.3 in leukemia is linked to the In Cis downregulation of a gene cluster that targets NF-kB. PLoS Genet 9: e1003373.
    • (2013) PLoS Genet , vol.9 , pp. e1003373
    • Garding, A.1    Bhattacharya, N.2    Claus, R.3    Ruppel, M.4    Tschuch, C.5    Filarsky, K.6
  • 74
    • 84876177255 scopus 로고    scopus 로고
    • A pseudogene long-noncoding-RNA network regulates PTEN transcription and translation in human cells
    • Johnsson, P, Ackley, A, Vidarsdottir, L, Lui, WO, Corcoran, M, Grandér, D et al. (2013). A pseudogene long-noncoding-RNA network regulates PTEN transcription and translation in human cells. Nat Struct Mol Biol 20: 440-446.
    • (2013) Nat Struct Mol Biol , vol.20 , pp. 440-446
    • Johnsson, P.1    Ackley, A.2    Vidarsdottir, L.3    Lui, W.O.4    Corcoran, M.5    Grandér, D.6
  • 76
    • 84873273556 scopus 로고    scopus 로고
    • Polycomb group protein EZH2-mediated E-cadherin repression promotes metastasis of oral tongue squamous cell carcinoma
    • Wang, C, Liu, X, Chen, Z, Huang, H, Jin, Y, Kolokythas, A et al. (2013). Polycomb group protein EZH2-mediated E-cadherin repression promotes metastasis of oral tongue squamous cell carcinoma. Mol Carcinog 52: 229-236.
    • (2013) Mol Carcinog , vol.52 , pp. 229-236
    • Wang, C.1    Liu, X.2    Chen, Z.3    Huang, H.4    Jin, Y.5    Kolokythas, A.6
  • 77
    • 84876714385 scopus 로고    scopus 로고
    • Long non-coding RNA H19 increases bladder cancer metastasis by associating with EZH2 and inhibiting E-cadherin expression
    • Luo, M, Li, Z, Wang, W, Zeng, Y, Liu, Z and Qiu, J (2013). Long non-coding RNA H19 increases bladder cancer metastasis by associating with EZH2 and inhibiting E-cadherin expression. Cancer Lett 333: 213-221.
    • (2013) Cancer Lett , vol.333 , pp. 213-221
    • Luo, M.1    Li, Z.2    Wang, W.3    Zeng, Y.4    Liu, Z.5    Qiu, J.6
  • 78
    • 84884782873 scopus 로고    scopus 로고
    • Pint lincRNA connects the p53 pathway with epigenetic silencing by the Polycomb repressive complex 2
    • Marín-Béjar, O, Marchese, FP, Athie, A, Sánchez, Y, González, J, Segura, V et al. (2013). Pint lincRNA connects the p53 pathway with epigenetic silencing by the Polycomb repressive complex 2. Genome Biol 14: R104.
    • (2013) Genome Biol , vol.14 , pp. R104
    • Marín-Béjar, O.1    Marchese, F.P.2    Athie, A.3    Sánchez, Y.4    González, J.5    Segura, V.6
  • 79
    • 84907960468 scopus 로고    scopus 로고
    • P53-regulated long non-coding RNA TUG1 affects cell proliferation in human non-small cell lung cancer, partly through epigenetically regulating HOXB7 expression
    • Zhang, EB, Yin, DD, Sun, M, Kong, R, Liu, XH, You, LH et al. (2014). P53-regulated long non-coding RNA TUG1 affects cell proliferation in human non-small cell lung cancer, partly through epigenetically regulating HOXB7 expression. Cell Death Dis 5: e1243.
    • (2014) Cell Death Dis , vol.5 , pp. e1243
    • Zhang, E.B.1    Yin, D.D.2    Sun, M.3    Kong, R.4    Liu, X.H.5    You, L.H.6
  • 80
    • 84902183146 scopus 로고    scopus 로고
    • An HIV-encoded antisense long noncoding RNA epigenetically regulates viral transcription
    • Saayman, S, Ackley, A, Turner, AM, Famiglietti, M, Bosque, A, Clemson, M et al. (2014). An HIV-encoded antisense long noncoding RNA epigenetically regulates viral transcription. Mol Ther 22: 1164-1175.
    • (2014) Mol Ther , vol.22 , pp. 1164-1175
    • Saayman, S.1    Ackley, A.2    Turner, A.M.3    Famiglietti, M.4    Bosque, A.5    Clemson, M.6
  • 82
    • 0017384270 scopus 로고
    • High density lipoprotein as a protective factor against coronary heart disease. The Framingham Study
    • Gordon, T, Castelli, WP, Hjortland, MC, Kannel, WB and Dawber, TR (1977). High density lipoprotein as a protective factor against coronary heart disease. The Framingham Study. Am J Med 62: 707-714.
    • (1977) Am J Med , vol.62 , pp. 707-714
    • Gordon, T.1    Castelli, W.P.2    Hjortland, M.C.3    Kannel, W.B.4    Dawber, T.R.5
  • 85
    • 84871408179 scopus 로고    scopus 로고
    • Neurotrophin regulation of neural circuit development and function
    • Park, H and Poo, MM (2013). Neurotrophin regulation of neural circuit development and function. Nat Rev Neurosci 14: 7-23.
    • (2013) Nat Rev Neurosci , vol.14 , pp. 7-23
    • Park, H.1    Poo, M.M.2
  • 86
    • 33750941251 scopus 로고    scopus 로고
    • Dysregulation of brain-derived neurotrophic factor expression and neurosecretory function in Mecp2 null mice
    • Wang, H, Chan, SA, Ogier, M, Hellard, D, Wang, Q, Smith, C et al. (2006). Dysregulation of brain-derived neurotrophic factor expression and neurosecretory function in Mecp2 null mice. J Neurosci 26: 10911-10915.
    • (2006) J Neurosci , vol.26 , pp. 10911-10915
    • Wang, H.1    Chan, S.A.2    Ogier, M.3    Hellard, D.4    Wang, Q.5    Smith, C.6
  • 87
    • 31044454138 scopus 로고    scopus 로고
    • The expanding role of BDNF: A therapeutic target for Alzheimer's disease?
    • Fumagalli, F, Racagni, G and Riva, MA (2006). The expanding role of BDNF: a therapeutic target for Alzheimer's disease? Pharmacogenomics J 6: 8-15.
    • (2006) Pharmacogenomics J , vol.6 , pp. 8-15
    • Fumagalli, F.1    Racagni, G.2    Riva, M.A.3
  • 88
    • 33645068212 scopus 로고    scopus 로고
    • Shedding light into the role of BDNF in the pharmacotherapy of Parkinson's disease
    • Fumagalli, F, Racagni, G and Riva, MA (2006). Shedding light into the role of BDNF in the pharmacotherapy of Parkinson's disease. Pharmacogenomics J 6: 95-104.
    • (2006) Pharmacogenomics J , vol.6 , pp. 95-104
    • Fumagalli, F.1    Racagni, G.2    Riva, M.A.3
  • 89
    • 84869016176 scopus 로고    scopus 로고
    • Activity-dependent human brain coding/noncoding gene regulatory networks
    • Lipovich, L, Dachet, F, Cai, J, Bagla, S, Balan, K, Jia, H et al. (2012). Activity-dependent human brain coding/noncoding gene regulatory networks. Genetics 192: 1133-1148.
    • (2012) Genetics , vol.192 , pp. 1133-1148
    • Lipovich, L.1    Dachet, F.2    Cai, J.3    Bagla, S.4    Balan, K.5    Jia, H.6
  • 90
    • 84883271723 scopus 로고    scopus 로고
    • Expression of non-protein-coding antisense RNAs in genomic regions related to autism spectrum disorders
    • Velmeshev, D, Magistri, M and Faghihi, MA (2013). Expression of non-protein-coding antisense RNAs in genomic regions related to autism spectrum disorders. Mol Autism 4: 32.
    • (2013) Mol Autism , vol.4 , pp. 32
    • Velmeshev, D.1    Magistri, M.2    Faghihi, M.A.3
  • 91
    • 84879152374 scopus 로고    scopus 로고
    • SYNGAP1 links the maturation rate of excitatory synapses to the duration of critical-period synaptic plasticity
    • Clement, JP, Ozkan, ED, Aceti, M, Miller, CA and Rumbaugh, G (2013). SYNGAP1 links the maturation rate of excitatory synapses to the duration of critical-period synaptic plasticity. J Neurosci 33: 10447-10452.
    • (2013) J Neurosci , vol.33 , pp. 10447-10452
    • Clement, J.P.1    Ozkan, E.D.2    Aceti, M.3    Miller, C.A.4    Rumbaugh, G.5
  • 92
    • 79952182383 scopus 로고    scopus 로고
    • Potential therapeutic uses of BDNF in neurological and psychiatric disorders
    • Nagahara, AH and Tuszynski, MH (2011). Potential therapeutic uses of BDNF in neurological and psychiatric disorders. Nat Rev Drug Discov 10: 209-219.
    • (2011) Nat Rev Drug Discov , vol.10 , pp. 209-219
    • Nagahara, A.H.1    Tuszynski, M.H.2
  • 93
    • 84880652927 scopus 로고    scopus 로고
    • Targeting long non-coding RNA to therapeutically upregulate gene expression
    • Wahlestedt, C (2013). Targeting long non-coding RNA to therapeutically upregulate gene expression. Nat Rev Drug Discov 12: 433-446.
    • (2013) Nat Rev Drug Discov , vol.12 , pp. 433-446
    • Wahlestedt, C.1
  • 94
    • 84879958098 scopus 로고    scopus 로고
    • Antisense oligonucleotides: Treating neurodegeneration at the level of RNA
    • DeVos, SL and Miller, TM (2013). Antisense oligonucleotides: treating neurodegeneration at the level of RNA. Neurotherapeutics 10: 486-497.
    • (2013) Neurotherapeutics , vol.10 , pp. 486-497
    • DeVos, S.L.1    Miller, T.M.2
  • 95
    • 77949676231 scopus 로고    scopus 로고
    • Locked nucleic acids: Promising nucleic acid analogs for therapeutic applications
    • Veedu, RN and Wengel, J (2010). Locked nucleic acids: promising nucleic acid analogs for therapeutic applications. Chem Biodivers 7: 536-542.
    • (2010) Chem Biodivers , vol.7 , pp. 536-542
    • Veedu, R.N.1    Wengel, J.2
  • 96
    • 84879662907 scopus 로고    scopus 로고
    • Small-molecule modulation of neurotrophin receptors: A strategy for the treatment of neurological disease
    • Longo, FM and Massa, SM (2013). Small-molecule modulation of neurotrophin receptors: a strategy for the treatment of neurological disease. Nat Rev Drug Discov 12: 507-525.
    • (2013) Nat Rev Drug Discov , vol.12 , pp. 507-525
    • Longo, F.M.1    Massa, S.M.2
  • 98
    • 84873451950 scopus 로고    scopus 로고
    • The noncoding RNA MALAT1 is a critical regulator of the metastasis phenotype of lung cancer cells
    • Gutschner, T, Hämmerle, M, Eissmann, M, Hsu, J, Kim, Y, Hung, G et al. (2013). The noncoding RNA MALAT1 is a critical regulator of the metastasis phenotype of lung cancer cells. Cancer Res 73: 1180-1189.
    • (2013) Cancer Res , vol.73 , pp. 1180-1189
    • Gutschner, T.1    Hämmerle, M.2    Eissmann, M.3    Hsu, J.4    Kim, Y.5    Hung, G.6
  • 99
    • 84865325124 scopus 로고    scopus 로고
    • Oral delivery of small RNA and DNA
    • Forbes, DC and Peppas, NA (2012). Oral delivery of small RNA and DNA. J Control Release 162: 438-445.
    • (2012) J Control Release , vol.162 , pp. 438-445
    • Forbes, D.C.1    Peppas, N.A.2
  • 101
    • 84894047761 scopus 로고    scopus 로고
    • Mipomersen (kynamro): A novel antisense oligonucleotide inhibitor for the management of homozygous familial hypercholesterolemia
    • Wong, E and Goldberg, T (2014). Mipomersen (kynamro): a novel antisense oligonucleotide inhibitor for the management of homozygous familial hypercholesterolemia. P T 39: 119-122.
    • (2014) P T , vol.39 , pp. 119-122
    • Wong, E.1    Goldberg, T.2
  • 102
    • 84877872340 scopus 로고    scopus 로고
    • Clinical trials using antisense oligonucleotides in duchenne muscular dystrophy
    • Koo, T and Wood, MJ (2013). Clinical trials using antisense oligonucleotides in duchenne muscular dystrophy. Hum Gene Ther 24: 479-488.
    • (2013) Hum Gene Ther , vol.24 , pp. 479-488
    • Koo, T.1    Wood, M.J.2
  • 103
    • 84856431819 scopus 로고    scopus 로고
    • RNA therapeutics: Beyond RNA interference and antisense oligonucleotides
    • Kole, R, Krainer, AR and Altman, S (2012). RNA therapeutics: beyond RNA interference and antisense oligonucleotides. Nat Rev Drug Discov 11: 125-140.
    • (2012) Nat Rev Drug Discov , vol.11 , pp. 125-140
    • Kole, R.1    Krainer, A.R.2    Altman, S.3
  • 104
    • 3242677639 scopus 로고    scopus 로고
    • siRNAs: Applications in functional genomics and potential as therapeutics
    • Dorsett, Y and Tuschl, T (2004). siRNAs: applications in functional genomics and potential as therapeutics. Nat Rev Drug Discov 3: 318-329.
    • (2004) Nat Rev Drug Discov , vol.3 , pp. 318-329
    • Dorsett, Y.1    Tuschl, T.2
  • 105
    • 79954580272 scopus 로고    scopus 로고
    • Current prospects for RNA interference-based therapies
    • Davidson, BL and McCray, PB Jr (2011). Current prospects for RNA interference-based therapies. Nat Rev Genet 12: 329-340.
    • (2011) Nat Rev Genet , vol.12 , pp. 329-340
    • Davidson, B.L.1    McCray, P.B.2
  • 106
    • 84879873039 scopus 로고    scopus 로고
    • Lentiviral hematopoietic stem cell gene therapy benefits metachromatic leukodystrophy
    • Biffi, A, Montini, E, Lorioli, L, Cesani, M, Fumagalli, F, Plati, T et al. (2013). Lentiviral hematopoietic stem cell gene therapy benefits metachromatic leukodystrophy. Science 341: 1233158.
    • (2013) Science , vol.341 , pp. 1233158
    • Biffi, A.1    Montini, E.2    Lorioli, L.3    Cesani, M.4    Fumagalli, F.5    Plati, T.6
  • 107
    • 84879867061 scopus 로고    scopus 로고
    • Lentiviral hematopoietic stem cell gene therapy in patients with Wiskott-Aldrich syndrome
    • Aiuti, A, Biasco, L, Scaramuzza, S, Ferrua, F, Cicalese, MP, Baricordi, C et al. (2013). Lentiviral hematopoietic stem cell gene therapy in patients with Wiskott-Aldrich syndrome. Science 341: 1233151.
    • (2013) Science , vol.341 , pp. 1233151
    • Aiuti, A.1    Biasco, L.2    Scaramuzza, S.3    Ferrua, F.4    Cicalese, M.P.5    Baricordi, C.6
  • 108
    • 77957594057 scopus 로고    scopus 로고
    • Emerging applications of lentiviral vectors in dendritic cell-based immunotherapy
    • Wang, H, Zhang, L and Kung, SK (2010). Emerging applications of lentiviral vectors in dendritic cell-based immunotherapy. Immunotherapy 2: 685-695.
    • (2010) Immunotherapy , vol.2 , pp. 685-695
    • Wang, H.1    Zhang, L.2    Kung, S.K.3
  • 109
    • 77955608799 scopus 로고    scopus 로고
    • RNA-based gene therapy for HIV with lentiviral vector-modified CD34(+) cells in patients undergoing transplantation for AIDS-related lymphoma
    • DiGiusto, DL, Krishnan, A, Li, L, Li, H, Li, S, Rao, A et al. (2010). RNA-based gene therapy for HIV with lentiviral vector-modified CD34(+) cells in patients undergoing transplantation for AIDS-related lymphoma. Sci Transl Med 2: 36ra43.
    • (2010) Sci Transl Med , vol.2 , pp. 36ra43
    • DiGiusto, D.L.1    Krishnan, A.2    Li, L.3    Li, H.4    Li, S.5    Rao, A.6
  • 110
    • 77949916296 scopus 로고    scopus 로고
    • Understanding protein non-folding
    • Uversky, VN and Dunker, AK (2010). Understanding protein non-folding. Biochim Biophys Acta 1804: 1231-1264.
    • (2010) Biochim Biophys Acta , vol.1804 , pp. 1231-1264
    • Uversky, V.N.1    Dunker, A.K.2
  • 111
    • 77949328500 scopus 로고    scopus 로고
    • The mysterious unfoldome: Structureless, underappreciated, yet vital part of any given proteome
    • Uversky, VN (2010). The mysterious unfoldome: structureless, underappreciated, yet vital part of any given proteome. J Biomed Biotechnol 2010: 568068.
    • (2010) J Biomed Biotechnol , vol.2010 , pp. 568068
    • Uversky, V.N.1
  • 112
    • 77954217602 scopus 로고    scopus 로고
    • The protein kingdom extended: Ordered and intrinsically disordered proteins, their folding, supramolecular complex formation, and aggregation
    • Turoverov, KK, Kuznetsova, IM and Uversky, VN (2010). The protein kingdom extended: ordered and intrinsically disordered proteins, their folding, supramolecular complex formation, and aggregation. Prog Biophys Mol Biol 102: 73-84.
    • (2010) Prog Biophys Mol Biol , vol.102 , pp. 73-84
    • Turoverov, K.K.1    Kuznetsova, I.M.2    Uversky, V.N.3
  • 113
    • 84861969926 scopus 로고    scopus 로고
    • Insights into RNA biology from an atlas of mammalian mRNA-binding proteins
    • Castello, A, Fischer, B, Eichelbaum, K, Horos, R, Beckmann, BM, Strein, C et al. (2012). Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149: 1393-1406.
    • (2012) Cell , vol.149 , pp. 1393-1406
    • Castello, A.1    Fischer, B.2    Eichelbaum, K.3    Horos, R.4    Beckmann, B.M.5    Strein, C.6
  • 114
    • 78149497463 scopus 로고    scopus 로고
    • Drugs for 'protein clouds': Targeting intrinsically disordered transcription factors
    • Dunker, AK and Uversky, VN (2010). Drugs for 'protein clouds': targeting intrinsically disordered transcription factors. Curr Opin Pharmacol 10: 782-788.
    • (2010) Curr Opin Pharmacol , vol.10 , pp. 782-788
    • Dunker, A.K.1    Uversky, V.N.2
  • 116
    • 78649807567 scopus 로고    scopus 로고
    • Phosphorylation of the PRC2 component Ezh2 is cell cycle-regulated and up-regulates its binding to ncRNA
    • Kaneko, S, Li, G, Son, J, Xu, CF, Margueron, R, Neubert, TA et al. (2010). Phosphorylation of the PRC2 component Ezh2 is cell cycle-regulated and up-regulates its binding to ncRNA. Genes Dev 24: 2615-2620.
    • (2010) Genes Dev , vol.24 , pp. 2615-2620
    • Kaneko, S.1    Li, G.2    Son, J.3    Xu, C.F.4    Margueron, R.5    Neubert, T.A.6
  • 117
    • 84904507962 scopus 로고    scopus 로고
    • Regulatory Interactions between RNA and Polycomb Repressive Complex 2
    • Cifuentes-Rojas, C, Hernandez, AJ, Sarma, K and Lee, JT (2014). Regulatory Interactions between RNA and Polycomb Repressive Complex 2. Mol Cell 55: 171-185.
    • (2014) Mol Cell , vol.55 , pp. 171-185
    • Cifuentes-Rojas, C.1    Hernandez, A.J.2    Sarma, K.3    Lee, J.T.4
  • 118
    • 84891511041 scopus 로고    scopus 로고
    • Binding interactions between long noncoding RNA HOTAIR and PRC2 proteins
    • Wu, L, Murat, P, Matak-Vinkovic, D, Murrell, A and Balasubramanian, S (2013). Binding interactions between long noncoding RNA HOTAIR and PRC2 proteins. Biochemistry 52: 9519-9527.
    • (2013) Biochemistry , vol.52 , pp. 9519-9527
    • Wu, L.1    Murat, P.2    Matak-Vinkovic, D.3    Murrell, A.4    Balasubramanian, S.5
  • 119
    • 84892999996 scopus 로고    scopus 로고
    • Methods for comprehensive experimental identification of RNA-protein interactions
    • McHugh, CA, Russell, P and Guttman, M (2014). Methods for comprehensive experimental identification of RNA-protein interactions. Genome Biol 15: 203.
    • (2014) Genome Biol , vol.15 , pp. 203
    • McHugh, C.A.1    Russell, P.2    Guttman, M.3
  • 120
    • 29444457713 scopus 로고    scopus 로고
    • Rapid evolution of noncoding RNAs: Lack of conservation does not mean lack of function
    • Pang, KC, Frith, MC and Mattick, JS (2006). Rapid evolution of noncoding RNAs: lack of conservation does not mean lack of function. Trends Genet 22: 1-5.
    • (2006) Trends Genet , vol.22 , pp. 1-5
    • Pang, K.C.1    Frith, M.C.2    Mattick, J.S.3
  • 121
    • 84890852686 scopus 로고    scopus 로고
    • Evolutionary conservation of long non-coding RNAs; sequence, structure, function
    • Johnsson, P, Lipovich, L, Grandér, D and Morris, KV (2014). Evolutionary conservation of long non-coding RNAs; sequence, structure, function. Biochim Biophys Acta 1840: 1063-1071.
    • (2014) Biochim Biophys Acta , vol.1840 , pp. 1063-1071
    • Johnsson, P.1    Lipovich, L.2    Grandér, D.3    Morris, K.V.4
  • 122
    • 84892919070 scopus 로고    scopus 로고
    • Methods to enable the design of bioactive small molecules targeting RNA
    • Disney, MD, Yildirim, I and Childs-Disney, JL (2014). Methods to enable the design of bioactive small molecules targeting RNA. Org Biomol Chem 12: 1029-1039.
    • (2014) Org Biomol Chem , vol.12 , pp. 1029-1039
    • Disney, M.D.1    Yildirim, I.2    Childs-Disney, J.L.3
  • 123
    • 43149103943 scopus 로고    scopus 로고
    • Targeting RNA with small molecules
    • Thomas, JR and Hergenrother, PJ (2008). Targeting RNA with small molecules. Chem Rev 108: 1171-1224.
    • (2008) Chem Rev , vol.108 , pp. 1171-1224
    • Thomas, J.R.1    Hergenrother, P.J.2
  • 124
    • 84873401224 scopus 로고    scopus 로고
    • Update on good use of injectable aminoglycosides, gentamycin, tobramycin, netilmycin, amikacin. Pharmacological properties, indications, dosage, and mode of administration, treatment monitoring
    • Agence franc¸aise de sécurité sanitaire des produits de santé. (2012). Update on good use of injectable aminoglycosides, gentamycin, tobramycin, netilmycin, amikacin. Pharmacological properties, indications, dosage, and mode of administration, treatment monitoring. Med Mal Infect 42: 301-308.
    • (2012) Med Mal Infect , vol.42 , pp. 301-308
    • Agence franc¸aise de sécurité sanitaire des produits de santé1
  • 126
    • 84892889808 scopus 로고    scopus 로고
    • Interactions between JARID2 and noncoding RNAs regulate PRC2 recruitment to chromatin
    • Kaneko, S, Bonasio, R, Saldaña-Meyer, R, Yoshida, T, Son, J, Nishino, K et al. (2014). Interactions between JARID2 and noncoding RNAs regulate PRC2 recruitment to chromatin. Mol Cell 53: 290-300.
    • (2014) Mol Cell , vol.53 , pp. 290-300
    • Kaneko, S.1    Bonasio, R.2    Saldaña-Meyer, R.3    Yoshida, T.4    Son, J.5    Nishino, K.6
  • 128
    • 84901804745 scopus 로고    scopus 로고
    • Quantitative analysis of RNA-protein interactions on a massively parallel array reveals biophysical and evolutionary landscapes
    • Buenrostro, JD, Araya, CL, Chircus, LM, Layton, CJ, Chang, HY, Snyder, MP et al. (2014). Quantitative analysis of RNA-protein interactions on a massively parallel array reveals biophysical and evolutionary landscapes. Nat Biotechnol 32: 562-568.
    • (2014) Nat Biotechnol , vol.32 , pp. 562-568
    • Buenrostro, J.D.1    Araya, C.L.2    Chircus, L.M.3    Layton, C.J.4    Chang, H.Y.5    Snyder, M.P.6
  • 129
    • 84901830722 scopus 로고    scopus 로고
    • Comprehensive analysis of RNA-protein interactions by high-throughput sequencing-RNA affinity profiling
    • Tome, JM, Ozer, A, Pagano, JM, Gheba, D, Schroth, GP and Lis, JT (2014). Comprehensive analysis of RNA-protein interactions by high-throughput sequencing-RNA affinity profiling. Nat Methods 11: 683-688.
    • (2014) Nat Methods , vol.11 , pp. 683-688
    • Tome, J.M.1    Ozer, A.2    Pagano, J.M.3    Gheba, D.4    Schroth, G.P.5    Lis, J.T.6
  • 130
    • 77956306662 scopus 로고    scopus 로고
    • Genome-wide measurement of RNA secondary structure in yeast
    • Kertesz, M, Wan, Y, Mazor, E, Rinn, JL, Nutter, RC, Chang, HY et al. (2010). Genome-wide measurement of RNA secondary structure in yeast. Nature 467: 103-107.
    • (2010) Nature , vol.467 , pp. 103-107
    • Kertesz, M.1    Wan, Y.2    Mazor, E.3    Rinn, J.L.4    Nutter, R.C.5    Chang, H.Y.6
  • 131
    • 67649774581 scopus 로고    scopus 로고
    • Unbiased RNA-protein interaction screen by quantitative proteomics
    • Butter, F, Scheibe, M, Mörl, M and Mann, M (2009). Unbiased RNA-protein interaction screen by quantitative proteomics. Proc Natl Acad Sci USA 106: 10626-10631.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 10626-10631
    • Butter, F.1    Scheibe, M.2    Mörl, M.3    Mann, M.4
  • 132
    • 84902682043 scopus 로고    scopus 로고
    • RAID: A comprehensive resource for human RNA-associated (RNA-RNA/RNA-protein) interaction
    • Zhang, X, Wu, D, Chen, L, Li, X, Yang, J, Fan, D et al. (2014). RAID: a comprehensive resource for human RNA-associated (RNA-RNA/RNA-protein) interaction. RNA 20: 989-993.
    • (2014) RNA , vol.20 , pp. 989-993
    • Zhang, X.1    Wu, D.2    Chen, L.3    Li, X.4    Yang, J.5    Fan, D.6
  • 133
    • 84873325566 scopus 로고    scopus 로고
    • SeqFold: Genome-scale reconstruction of RNA secondary structure integrating high-throughput sequencing data
    • Ouyang, Z, Snyder, MP and Chang, HY (2013). SeqFold: genome-scale reconstruction of RNA secondary structure integrating high-throughput sequencing data. Genome Res 23: 377-387.
    • (2013) Genome Res , vol.23 , pp. 377-387
    • Ouyang, Z.1    Snyder, M.P.2    Chang, H.Y.3
  • 135
    • 84893358533 scopus 로고    scopus 로고
    • Landscape and variation of RNA secondary structure across the human transcriptome
    • Wan, Y, Qu, K, Zhang, QC, Flynn, RA, Manor, O, Ouyang, Z et al. (2014). Landscape and variation of RNA secondary structure across the human transcriptome. Nature 505: 706-709.
    • (2014) Nature , vol.505 , pp. 706-709
    • Wan, Y.1    Qu, K.2    Zhang, Q.C.3    Flynn, R.A.4    Manor, O.5    Ouyang, Z.6
  • 136
    • 84883214592 scopus 로고    scopus 로고
    • Sizing up long non-coding RNAs: Do lncRNAs have secondary and tertiary structure?
    • Novikova, IV, Hennelly, SP and Sanbonmatsu, KY (2012). Sizing up long non-coding RNAs: do lncRNAs have secondary and tertiary structure? Bioarchitecture 2: 189-199.
    • (2012) Bioarchitecture , vol.2 , pp. 189-199
    • Novikova, I.V.1    Hennelly, S.P.2    Sanbonmatsu, K.Y.3


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