Inhibition of natural antisense transcripts in vivo results in gene-specific transcriptional upregulation

Nature Biotechnology

Volumn 30, Issue 5, 2012, Pages 453-459

  Modarresi, Farzaneh ^a   Faghihi, Mohammad Ali ^a   Lopez Toledano, Miguel A ^b   Fatemi, Roya Pedram ^a   Magistri, Marco ^a   Brothers, Shaun P ^a   Van Der Brug, Marcel P ^c   Wahlestedt, Claes ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b FLORIDA ATLANTIC UNIVERSITY   (United States)

^c GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE; ANTISENSE RNA; BRAIN-DERIVED NEUROTROPHIC FACTORS; IN-VITRO; IN-VIVO; NEUROTROPHIC FACTORS; PROTEIN LEVEL; UP-REGULATION;

DEGRADATION; GENE EXPRESSION; OLIGONUCLEOTIDES; RNA;

GENE THERAPY;

ANTAGONAT3 PROTEIN; ANTAGONAT4 PROTEIN; ANTAGONAT5 PROTEIN; ANTAGONAT6 PROTEIN; ANTAGONAT9 PROTEIN; BRAIN DERIVED NEUROTROPHIC FACTOR; COMPLEMENTARY RNA; EPHRIN RECEPTOR B2; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; MESSENGER RNA; NATURAL ANTISENSE TRANSCRIPTION FACTOR; PROTEIN INHIBITOR; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; GENE LOCUS; GENE REPRESSION; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; MOLECULARLY TARGETED THERAPY; NERVE FIBER GROWTH; NONHUMAN; PRIORITY JOURNAL; PROTEIN TARGETING; RNA STABILITY; TRANSCRIPTION REGULATION;

ANIMALS; CELL LINE; CHROMATIN; EXONS; GENE EXPRESSION PROFILING; GENOMICS; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; HEK293 CELLS; HUMANS; MICE; MODELS, GENETIC; OLIGONUCLEOTIDES, ANTISENSE; RECEPTOR, EPHB2; RNA, MESSENGER; RNA, SMALL INTERFERING; SEQUENCE ANALYSIS, DNA; TRANSCRIPTION, GENETIC; UP-REGULATION;

EID: 84860353437     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt.2158     Document Type: Article

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