The cyclopentenone prostaglandin 15d-PGJ2 inhibits the NLRP1 and NLRP3 inflammasomes

Journal of Immunology

Volumn 194, Issue 6, 2015, Pages 2776-2785

  Maier, Nolan K ^a   Leppla, Stephen H ^a   Moayeri, Mahtab ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

15 DEOXY DELTA12,14 PROSTAGLANDIN J2; CRYOPYRIN; CYCLOOXYGENASE 1; GLUTATHIONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; MITOGEN ACTIVATED PROTEIN KINASE KINASE; NLR FAMILY LEUCINE RICH REPEAT PROTEIN 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; PLACEBO; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; URATE; 15-DEOXYPROSTAGLANDIN J2; APOPTOSIS REGULATORY PROTEIN; BACTERIAL TOXIN; CARRIER PROTEIN; CIAS1 PROTEIN, MOUSE; CYTOKINE; NALP1 PROTEIN, MOUSE; PROSTAGLANDIN D2; PROTECTIVE AGENT; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTHRAX; ANTIBACTERIAL ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BACILLUS ANTHRACIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DRUG PROTEIN BINDING; DRUG TARGETING; ENZYME INACTIVATION; ENZYME INHIBITION; GOUT; MOUSE; MOUSE MODEL; NONHUMAN; PERITONITIS; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; PROTEIN CLEAVAGE; TRANSCRIPTION REGULATION; ANALOGS AND DERIVATIVES; ANIMAL; APOPTOSIS; BAGG ALBINO MOUSE; C57BL MOUSE; CELL CULTURE; CELL LINE; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; KNOCKOUT MOUSE; MACROPHAGE; METABOLISM; PROTEIN DEGRADATION; PROTEIN SYNTHESIS; TUMOR CELL LINE; WESTERN BLOTTING;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BACILLUS ANTHRACIS; BACTERIAL TOXINS; BLOTTING, WESTERN; CARRIER PROTEINS; CASPASE 1; CELL LINE; CELL LINE, TUMOR; CELL SURVIVAL; CELLS, CULTURED; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; INFLAMMASOMES; MACROPHAGES; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; MOLECULAR STRUCTURE; PROSTAGLANDIN D2; PROTECTIVE AGENTS; PROTEIN BIOSYNTHESIS; PROTEOLYSIS;

EID: 84924565877     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1401611     Document Type: Article

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