Inhibition of skin sclerosis by 15deoxy Δ12,14- prostaglandin J2 and retrovirally transfected prostaglandin D synthase in a mouse model of bleomycin-induced scleroderma

Biomedicine and Pharmacotherapy

Volumn 60, Issue 1, 2006, Pages 18-25

  Kohno, Shizuka ^a   Endo, Hirahito ^a   Hashimoto, Atsushi ^a   Hayashi, Izumi ^b   Murakami, Yusuke ^a   Kitasato, Hidero ^c   Kojima, Fumiaki ^d   Kawai, Shinichi ^e   Kondo, Hirobumi ^a  

^a KITASATO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b Department of Pharmacology ^*  (Japan)

^c KITASATO UNIVERSITY   (Japan)

^d ST MARIANNA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^e TOHO UNIVERSITY   (Japan)

Author keywords

15d PGJ2; Mast cell; PPAR ; Scleroderma; Skin sclerosis

Indexed keywords

15 DEOXY DELTA12,14 PROSTAGLANDIN J2; BLEOMYCIN; COMPLEMENTARY DNA; CONNECTIVE TISSUE GROWTH FACTOR; HISTAMINE; HYDROXYPROLINE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROSTAGLANDIN D SYNTHASE; RETROVIRUS VECTOR; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEGRANULATION; DNA TRANSFECTION; DOWN REGULATION; DRUG TARGETING; EXPERIMENTAL MODEL; EXPERIMENTAL MOUSE; FEMALE; FIBROBLAST; HISTAMINE BLOOD LEVEL; HISTOPATHOLOGY; MAST CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCLERODERMA; SKIN DEFECT; SKINFOLD THICKNESS; STATISTICAL SIGNIFICANCE;

ANIMALS; BLEOMYCIN; CONNECTIVE TISSUE GROWTH FACTOR; DISEASE MODELS, ANIMAL; FEMALE; FIBROBLASTS; HISTAMINE RELEASE; HYDROXYPROLINE; IMMEDIATE-EARLY PROTEINS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; INTRAMOLECULAR OXIDOREDUCTASES; LIPOCALINS; MAST CELLS; MICE; MICE, INBRED C3H; PROSTAGLANDIN D2; RNA, MESSENGER; SCLERODERMA, SYSTEMIC; SCLEROSIS; SKIN; TRANSFECTION;

EID: 29244437849     PISSN: 07533322     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopha.2005.04.004     Document Type: Article

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