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Volumn 106, Issue 2, 2000, Pages 189-197

15-deoxy-Δ12,14-PGJ2 induces synoviocyte apoptosis and suppresses adjuvant-induced arthritis in rats

Author keywords

[No Author keywords available]

Indexed keywords

DELTA12 PROSTAGLANDIN J2; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR;

EID: 0033925031     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI9652     Document Type: Article
Times cited : (374)

References (56)
  • 2
    • 0032091809 scopus 로고    scopus 로고
    • Angiogenesis: Implications of rheumatoid arthritis
    • Koch, A.E. 1998. Angiogenesis: implications of rheumatoid arthritis. Artbritis Rheum. 41:951-962.
    • (1998) Artbritis Rheum. , vol.41 , pp. 951-962
    • Koch, A.E.1
  • 3
    • 0031809547 scopus 로고    scopus 로고
    • The role of nitric oxide in inflammation and immunity
    • Clancy, R.M., Amin, A.R., and Abramson, S.B. 1998. The role of nitric oxide in inflammation and immunity. Arthritis Rheum. 41:1141-1151.
    • (1998) Arthritis Rheum. , vol.41 , pp. 1141-1151
    • Clancy, R.M.1    Amin, A.R.2    Abramson, S.B.3
  • 4
    • 0023764989 scopus 로고
    • Cytokines in synovial fluid: II. the presence of tumour necrosis factor and interferon
    • Hopkins, S.J., and Meager, A. 1988. Cytokines in synovial fluid: II. The presence of tumour necrosis factor and interferon. Clin. Exp. Immunol. 73:88-92.
    • (1988) Clin. Exp. Immunol. , vol.73 , pp. 88-92
    • Hopkins, S.J.1    Meager, A.2
  • 5
    • 0020323211 scopus 로고
    • Inrerleukni-1 activity in the synovial fluid of patients with rheumatoid arthritis
    • Fontana, A., et al. 1982. Inrerleukni-1 activity in the synovial fluid of patients with rheumatoid arthritis. Rheumatol. Int. 2:49-53.
    • (1982) Rheumatol. Int. , vol.2 , pp. 49-53
    • Fontana, A.1
  • 6
    • 0013511183 scopus 로고    scopus 로고
    • Treatment of rheumatoid arthritis with a recombinant human tumor necrosis factor (p75)-Fc fusion protein
    • Moreland, L.W., et al. 1997. Treatment of rheumatoid arthritis with a recombinant human tumor necrosis factor (p75)-Fc fusion protein. N. Engl. J. Med. 337:141-147.
    • (1997) N. Engl. J. Med. , vol.337 , pp. 141-147
    • Moreland, L.W.1
  • 7
    • 0028143211 scopus 로고
    • Randomized double-blind comparison of chimeric monoclonal antibody to tumor necrosis factor α(cA2) versus placebo in rheumatoid arthritis
    • Elliott, M.J., et al. 1994. Randomized double-blind comparison of chimeric monoclonal antibody to tumor necrosis factor α(cA2) versus placebo in rheumatoid arthritis. Lancet. 344:1105-1110.
    • (1994) Lancet , vol.344 , pp. 1105-1110
    • Elliott, M.J.1
  • 8
    • 0029943271 scopus 로고    scopus 로고
    • Dose-range and dose-frequency study of recombinant human interleukin-1 receptor antagonist in patients with rheumatoid arthritis
    • Campion, G.V., et al. 1996. Dose-range and dose-frequency study of recombinant human interleukin-1 receptor antagonist in patients with rheumatoid arthritis. Arthritis Rheum. 39:1092-1101.
    • (1996) Arthritis Rheum. , vol.39 , pp. 1092-1101
    • Campion, G.V.1
  • 10
    • 84907119011 scopus 로고
    • Synovial processes in rheumatoid arthritis
    • Fassbender, H.G., and Gay, S. 1988. Synovial processes in rheumatoid arthritis. Scand J. Rheumatol. 76:1-7.
    • (1988) Scand J. Rheumatol. , vol.76 , pp. 1-7
    • Fassbender, H.G.1    Gay, S.2
  • 11
    • 0012473279 scopus 로고
    • The nuclear receptor superfamily: The second decade
    • Mangelsdorf, D.J., et al. 1995. The nuclear receptor superfamily: the second decade. Cell. 83:835-839.
    • (1995) Cell , vol.83 , pp. 835-839
    • Mangelsdorf, D.J.1
  • 12
    • 0025132245 scopus 로고
    • Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators
    • Issemann, I., and Grenn, S. 1990. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature. 347:645-050.
    • (1990) Nature , vol.347 , pp. 645-1050
    • Issemann, I.1    Grenn, S.2
  • 14
    • 0028321529 scopus 로고
    • Differential expression and activation of a family of murine peroxisome proliferator-activated receptors. Proc
    • Kliewer, S.A., et al. 1994. Differential expression and activation of a family of murine peroxisome proliferator-activated receptors. Proc. Natl. Acad. Sci. USA. 91:7355-7359.
    • (1994) Natl. Acad. Sci. USA , vol.91 , pp. 7355-7359
    • Kliewer, S.A.1
  • 15
    • 0027191040 scopus 로고
    • cDNA cloning, chromosomal mapping, and functional characterization of the human peroxisome proliferator activated receptor
    • Sher, T., Yi, H.-F., McBride, O.W., and Gonzalez, F.J. 1993. cDNA cloning, chromosomal mapping, and functional characterization of the human peroxisome proliferator activated receptor. Biochemistry. 32:5598-5604.
    • (1993) Biochemistry , vol.32 , pp. 5598-5604
    • Sher, T.1    Yi, H.-F.2    McBride, O.W.3    Gonzalez, F.J.4
  • 16
    • 0030047806 scopus 로고    scopus 로고
    • Differential expression of peroxisome proliferator-activated receptors (PPARs): Tissue distribution of PPAR-α, -β, and -γ in the adult rat
    • Braissant, O., Foufelle, F., Scotto, C., Dauca, M., and Wahli, W. 1996. Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-α, -β, and -γ in the adult rat. Endocrinol. 137:354-366.
    • (1996) Endocrinol. , vol.137 , pp. 354-366
    • Braissant, O.1    Foufelle, F.2    Scotto, C.3    Dauca, M.4    Wahli, W.5
  • 17
    • 0026785388 scopus 로고
    • Identification of a new member of the steroid hormone receptor superfamily that is accivated by peroxisonic proliferator and fatty acid
    • Schmidt, A., et al. 1992. Identification of a new member of the steroid hormone receptor superfamily that is accivated by peroxisonic proliferator and fatty acid. Mol. Endocrinol. 6:1634-1641.
    • (1992) Mol. Endocrinol. , vol.6 , pp. 1634-1641
    • Schmidt, A.1
  • 18
    • 0033615352 scopus 로고    scopus 로고
    • PPARδ is an APC-regulated target of nosteroidal anti-inflammatory drugs
    • He, T.C., Chan, T.A., Vogelstein, B., and Kinzler, K.W. 1999. PPARδ is an APC-regulated target of nosteroidal anti-inflammatory drugs. Cell. 99:335-345.
    • (1999) Cell , vol.99 , pp. 335-345
    • He, T.C.1    Chan, T.A.2    Vogelstein, B.3    Kinzler, K.W.4
  • 19
    • 0028641559 scopus 로고
    • Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor
    • Tontonoz, P., Hu, E., and Spiegelman, B.M. 1994. Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor. Cell. 79:1147-1156.
    • (1994) Cell , vol.79 , pp. 1147-1156
    • Tontonoz, P.1    Hu, E.2    Spiegelman, B.M.3
  • 20
    • 0030574219 scopus 로고    scopus 로고
    • Inflammation. Signalling the fat controller
    • Serhan, C.N. 1996. Inflammation. Signalling the fat controller. Nature. 384:23-24.
    • (1996) Nature , vol.384 , pp. 23-24
    • Serhan, C.N.1
  • 21
    • 0029661982 scopus 로고    scopus 로고
    • The PPARα-leukotriene B4 pathway to inflammation control
    • Devchand, P.R., et al. 1996. The PPARα-leukotriene B4 pathway to inflammation control. Nature. 384:39-43.
    • (1996) Nature , vol.384 , pp. 39-43
    • Devchand, P.R.1
  • 22
    • 0029152375 scopus 로고
    • Isolation of the human peroxisome proliferator-activated receptor γ cDNA: Expression in hematopoietic cells and chromosomal mapping
    • Greene, M.E., et al. 1995. Isolation of the human peroxisome proliferator-activated receptor γ cDNA: expression in hematopoietic cells and chromosomal mapping. Gene Expr. 4:281-299.
    • (1995) Gene Expr. , vol.4 , pp. 281-299
    • Greene, M.E.1
  • 23
    • 0034141545 scopus 로고    scopus 로고
    • The nuclear receptor PPARγ and immunoregulation: PPARγ mediates inhibition of helper T cell responses
    • Clark, R.B., et al. 2000. The nuclear receptor PPARγ and immunoregulation: PPARγ mediates inhibition of helper T cell responses. J. Immunol. 164:1364-1371.
    • (2000) J. Immunol. , vol.164 , pp. 1364-1371
    • Clark, R.B.1
  • 24
    • 0031886864 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation
    • Ricote, M., Li, A.C., Willson, T.M., Kelly, C.J., and Glass, C.K. 1998. The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation. Nature. 391:79-82.
    • (1998) Nature , vol.391 , pp. 79-82
    • Ricote, M.1    Li, A.C.2    Willson, T.M.3    Kelly, C.J.4    Glass, C.K.5
  • 25
    • 0031888958 scopus 로고    scopus 로고
    • PPAR-γ agonists inhibit production of monocyte inflammatory cytokines
    • Jiang, C., Ting, A.T., and Seed, B. 1998. PPAR-γ agonists inhibit production of monocyte inflammatory cytokines. Nature. 391:82-86.
    • (1998) Nature , vol.391 , pp. 82-86
    • Jiang, C.1    Ting, A.T.2    Seed, B.3
  • 26
    • 0031671246 scopus 로고    scopus 로고
    • Differentiation and reversal of malignant changes in colon cancer through PPARγ
    • Sarraf, P., et al. 1998. Differentiation and reversal of malignant changes in colon cancer through PPARγ. Nat. Med. 4:1046-1052.
    • (1998) Nat. Med. , vol.4 , pp. 1046-1052
    • Sarraf, P.1
  • 27
    • 0032145363 scopus 로고    scopus 로고
    • Ligand for peroxisome-proliferator activated receptor γ(Troglitazone) has potent antitumor effect against human prosrate cancer in vitro and in vivo
    • Kubota, T., et al. 1998. Ligand for peroxisome-proliferator activated receptor γ(Troglitazone) has potent antitumor effect against human prosrate cancer in vitro and in vivo. Cancer Res. 58:3344-3352.
    • (1998) Cancer Res. , vol.58 , pp. 3344-3352
    • Kubota, T.1
  • 28
    • 0032555196 scopus 로고    scopus 로고
    • Ligands for peroxisome-proliferator activated receptor γ and retinoic acid receptor inhibit growth and induce apoptosis of human breast cancer cells in vitro and in BNX mice
    • Elstner, E., et al. 1998. Ligands for peroxisome-proliferator activated receptor γ and retinoic acid receptor inhibit growth and induce apoptosis of human breast cancer cells in vitro and in BNX mice. Proc. Natl. Acad. Sci. USA. 95:3806-8811.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 3806-8811
    • Elstner, E.1
  • 29
    • 0032475922 scopus 로고    scopus 로고
    • Activation of peroxisome-activated receptor α and γ induces apoptosis of human monocyte-derived macrophages
    • Chinetti, G., et al. 1998. Activation of peroxisome-activated receptor α and γ induces apoptosis of human monocyte-derived macrophages J. Biol. Chem. 273:25573-25580.
    • (1998) J. Biol. Chem. , vol.273 , pp. 25573-25580
    • Chinetti, G.1
  • 30
    • 0030612740 scopus 로고    scopus 로고
    • PPARγy induces cell cycle withdrawal: Inhibition of E2F/DP DNA binding activity via down-regulation of PP2A
    • Altoik, S., Xu, M., and Spiegelman, B.M. 1997. PPARγy induces cell cycle withdrawal: inhibition of E2F/DP DNA binding activity via down-regulation of PP2A. Genes Dev. 11:1987-1998.
    • (1997) Genes Dev. , vol.11 , pp. 1987-1998
    • Altoik, S.1    Xu, M.2    Spiegelman, B.M.3
  • 32
    • 0030952937 scopus 로고    scopus 로고
    • Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and δ
    • Forman, B.M., Chen, J., and Evans, R.M. 1997. Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and δ. Proc. Natl. Acad. Sci. USA. 94:4312-4317.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 4312-4317
    • Forman, B.M.1    Chen, J.2    Evans, R.M.3
  • 33
    • 0021894549 scopus 로고
    • Effects of manipulation of dietary fatty acids on clinical manifestations of rheumatoid arthritis
    • Kremer, J.M., et al. 1985. Effects of manipulation of dietary fatty acids on clinical manifestations of rheumatoid arthritis. Lancet. 1:184-187.
    • (1985) Lancet , vol.1 , pp. 184-187
    • Kremer, J.M.1
  • 34
    • 0029168043 scopus 로고
    • Effects of high-dose fish oil on rheumatoid arthritis after stopping nonsteroidal antiinflammatory drugs
    • Kremer, J.M., et al. 1995. Effects of high-dose fish oil on rheumatoid arthritis after stopping nonsteroidal antiinflammatory drugs. Arthritis Rheum. 38:1107-1114.
    • (1995) Arthritis Rheum. , vol.38 , pp. 1107-1114
    • Kremer, J.M.1
  • 35
    • 0031013395 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors α and γ are activated by indomethacin and other non-steroidal anti-inflammatory drugs
    • Lehmann, J.M., Lenhard, J.M., Oliver, B.B., Ringold, G.M., and Kliewer, S.A. 1997. Peroxisome proliferator-activated receptors α and γ are activated by indomethacin and other non-steroidal anti-inflammatory drugs. J. Biol. Chem. 272:3406-3410.
    • (1997) J. Biol. Chem. , vol.272 , pp. 3406-3410
    • Lehmann, J.M.1    Lenhard, J.M.2    Oliver, B.B.3    Ringold, G.M.4    Kliewer, S.A.5
  • 36
    • 0027480087 scopus 로고
    • Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs
    • Meade, L.A., Smith, W.L., and DeWitt, D.L. 1993. Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs. J. Biol. Chem. 268:6610-6614.
    • (1993) J. Biol. Chem. , vol.268 , pp. 6610-6614
    • Meade, L.A.1    Smith, W.L.2    DeWitt, D.L.3
  • 37
    • 0031445542 scopus 로고    scopus 로고
    • Th1/Th2 cytokine balance in arthritis
    • Miossec, P., and van den Berg, W. 1997. Th1/Th2 cytokine balance in arthritis. Arthritis Rheum. 40:2105-2115.
    • (1997) Arthritis Rheum. , vol.40 , pp. 2105-2115
    • Miossec, P.1    Van Den Berg, W.2
  • 38
    • 0033595261 scopus 로고    scopus 로고
    • Interleukin-4-dependent production of PPAR-γ ligands in microphage by 12/15-lipoxygenase
    • Huang, J.T., et al. 1999. Interleukin-4-dependent production of PPAR-γ ligands in microphage by 12/15-lipoxygenase. Nature. 400:378-382.
    • (1999) Nature , vol.400 , pp. 378-382
    • Huang, J.T.1
  • 39
    • 0026531534 scopus 로고
    • In vivo cyclooxygenase expression in synovial tissues of patients with rheumatoid arthritis and osteoarthritis and rats with adjuvant and streptococcal cell wall arthritis
    • Sano, H., et al. 1992. In vivo cyclooxygenase expression in synovial tissues of patients with rheumatoid arthritis and osteoarthritis and rats with adjuvant and streptococcal cell wall arthritis. J. Clin. Invest. 89:97-108.
    • (1992) J. Clin. Invest. , vol.89 , pp. 97-108
    • Sano, H.1
  • 40
    • 0032946690 scopus 로고    scopus 로고
    • C-myc antisense deoxyoligonucleotide can induce apoptosis and Fas downregulation in rheumatoid synoviocyte
    • Hashiramoto, A., et al. 1999. C-myc antisense deoxyoligonucleotide can induce apoptosis and Fas downregulation in rheumatoid synoviocyte. Arthritis Rheum. 42:954-962.
    • (1999) Arthritis Rheum. , vol.42 , pp. 954-962
    • Hashiramoto, A.1
  • 41
    • 0030747895 scopus 로고    scopus 로고
    • Tissue distribution and quantification of the expression of mRNAs of peroxisome proliferator-activated receptors and liver X receptor-α in humans: No alteration in adipose tissue of obese and NIDDM patients
    • Auboeuf, D., et al. 1997. Tissue distribution and quantification of the expression of mRNAs of peroxisome proliferator-activated receptors and liver X receptor-α in humans: no alteration in adipose tissue of obese and NIDDM patients. Diabetes. 46:1319-1327.
    • (1997) Diabetes , vol.46 , pp. 1319-1327
    • Auboeuf, D.1
  • 42
    • 0032762976 scopus 로고    scopus 로고
    • Auranofin inhibits interleukin-1β-induced transcript of cyclooxygenase-2 on cultured human synoviocytes
    • Yamada, R., et al. 1999. Auranofin inhibits interleukin-1β-induced transcript of cyclooxygenase-2 on cultured human synoviocytes. Eur. J. Pharmacol. 385:71-79.
    • (1999) Eur. J. Pharmacol. , vol.385 , pp. 71-79
    • Yamada, R.1
  • 43
    • 0032532596 scopus 로고    scopus 로고
    • Localization of quantitative trait loci regulating adjuvant induced arthritis: Evidence for genetic factors common to multiple autoimmune diseases
    • Kawahito, V., et al. 1998. Localization of quantitative trait loci regulating adjuvant induced arthritis: evidence for genetic factors common to multiple autoimmune diseases. J. Immunol. 161:4411-4419.
    • (1998) J. Immunol. , vol.161 , pp. 4411-4419
    • Kawahito, V.1
  • 44
    • 0032587245 scopus 로고    scopus 로고
    • INK4a senescence gene as a new therapeutic strategy for the treatment of rheumatoid arthitis
    • INK4a senescence gene as a new therapeutic strategy for the treatment of rheumatoid arthitis. Nat. Med. 5:760-767.
    • (1999) Nat. Med. , vol.5 , pp. 760-767
    • Taniguchi, K.1
  • 45
    • 0032540012 scopus 로고    scopus 로고
    • PPARγ promote monocyte/macrophage differentiation and uptake of oxidized LDL
    • Tontonoz, P., Nagy, L., Alvarez, J.G.A., Thomazy, V.A., and Evans, R.M. 1998. PPARγ promote monocyte/macrophage differentiation and uptake of oxidized LDL. Cell. 93:241-252.
    • (1998) Cell , vol.93 , pp. 241-252
    • Tontonoz, P.1    Nagy, L.2    Alvarez, J.G.A.3    Thomazy, V.A.4    Evans, R.M.5
  • 46
    • 0033605677 scopus 로고    scopus 로고
    • Peroxisome proliferator-acrivated receptor γ ligands are potent inhibitors of angiogenesis in vitro and in vivo
    • Xin, X., Yang, S., Kowalski, J., and Gerritsen, M.E. 1999. Peroxisome proliferator-acrivated receptor γ ligands are potent inhibitors of angiogenesis in vitro and in vivo. J. Biol. Chem. 274:9116-9121.
    • (1999) J. Biol. Chem. , vol.274 , pp. 9116-9121
    • Xin, X.1    Yang, S.2    Kowalski, J.3    Gerritsen, M.E.4
  • 47
    • 0023818286 scopus 로고
    • The biology and pharmacology of PGD2
    • Giles, H., and Leff, P. 1988. The biology and pharmacology of PGD2. Prostaglandins. 35:277-300.
    • (1988) Prostaglandins , vol.35 , pp. 277-300
    • Giles, H.1    Leff, P.2
  • 48
    • 0033597210 scopus 로고    scopus 로고
    • Arachidonic acid is preferentially metabolized by cyclooxygenase-2 to prostacyclin and prostaglandin E2
    • Brock, T.G., McNish, R.W., and Peters-Golden, M, 1999. Arachidonic acid is preferentially metabolized by cyclooxygenase-2 to prostacyclin and prostaglandin E2. J. Biol. Chem. 274:11660-11666.
    • (1999) J. Biol. Chem. , vol.274 , pp. 11660-11666
    • Brock, T.G.1    McNish, R.W.2    Peters-Golden, M.3
  • 49
    • 0023796962 scopus 로고
    • Occurrence of 9-deoxy-Δ9,Δ12-13, 14-dihydro-prostaglandin D2 in human urine
    • Hirata, Y., et al. 1988. Occurrence of 9-deoxy-Δ9,Δ12-13, 14-dihydro-prostaglandin D2 in human urine. J. Biol. Chem. 263:16619-16625.
    • (1988) J. Biol. Chem. , vol.263 , pp. 16619-16625
    • Hirata, Y.1
  • 50
    • 0033000906 scopus 로고    scopus 로고
    • Inducible cyclooxygense may have antiinflammatory properties
    • Gilroy, D.W., et al. 1999. Inducible cyclooxygense may have antiinflammatory properties. Nat. Med. 5:698-701.
    • (1999) Nat. Med. , vol.5 , pp. 698-701
    • Gilroy, D.W.1
  • 53
    • 0023031770 scopus 로고
    • Site and mechanism of growth inhibition by prostaglandins. II. Temperature-dependent transfer of a cyclopentenone prostaglandin to nuclei
    • Narumiya, S., Ohno, K., Fijiwara, M., and Fukushima, M. 1986. Site and mechanism of growth inhibition by prostaglandins. II. Temperature-dependent transfer of a cyclopentenone prostaglandin to nuclei. J. Phamacol. Exp. Ther. 239:506-511.
    • (1986) J. Phamacol. Exp. Ther. , vol.239 , pp. 506-511
    • Narumiya, S.1    Ohno, K.2    Fijiwara, M.3    Fukushima, M.4
  • 54
    • 0034610759 scopus 로고    scopus 로고
    • Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IκB kinase
    • Rossi, A., et al. 2000. Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IκB kinase. Nature. 403:103-118.
    • (2000) Nature , vol.403 , pp. 103-118
    • Rossi, A.1
  • 55
    • 0034712933 scopus 로고    scopus 로고
    • 15-Deoxy-δ12, 14-prostaglandin J2 inhibits multiple steps in the NF-κB signaling pathway
    • Straus, D.S., et al. 2000. 15-Deoxy-δ12, 14-prostaglandin J2 inhibits multiple steps in the NF-κB signaling pathway. Proc. Natl. Acad. Sci. USA. 97:4844-4849.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 4844-4849
    • Straus, D.S.1
  • 56
    • 0032568309 scopus 로고    scopus 로고
    • A novel antidiabetic drug, troglitazone: Reason for hope and concern
    • Imura, H. 1998. A novel antidiabetic drug, troglitazone: reason for hope and concern. N. Engl. J. Med. 338:908-909.
    • (1998) N. Engl. J. Med. , vol.338 , pp. 908-909
    • Imura, H.1


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