Partial loss of presenilin impairs age-dependent neuronal survival in the cerebral cortex

Journal of Neuroscience

Volumn 34, Issue 48, 2014, Pages 15912-15922

  Watanabe, Hirotaka ^a   Iqbal, Minah ^a   Zheng, Jin ^a   Wines Samuelson, Mary ^a   Shen, Jie ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Alzheimers disease; Conditional knockout; Dementia; Gamma secretase; Neurodegeneration; Neuronal survival

Indexed keywords

AMYLOID PRECURSOR PROTEIN; ANTERIOR PHARYNX DEFECTIVE 1 PROTEIN; CASPASE 3; GAMMA SECRETASE; GLIAL FIBRILLARY ACIDIC PROTEIN; NEURON SPECIFIC NUCLEAR PROTEIN; NICASTRIN; PRESENILIN; PRESENILIN 1; PRESENILIN 2; PRESENILIN 1, MOUSE; PSEN2 PROTEIN, MOUSE;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS ASSAY; ARTICLE; ASTROCYTOSIS; BIOACCUMULATION; BRAIN CORTEX; BRAIN WEIGHT; CELL SURVIVAL; CONTROLLED STUDY; DEMENTIA; FEMALE; FLUORESCENCE MICROSCOPY; GENE EXPRESSION; GLIOSIS; HIPPOCAMPUS; HISTOLOGY; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; MOUSE; NEOCORTEX; NERVE DEGENERATION; NICK END LABELING; NISSL STAINING; NONHUMAN; QUANTITATIVE ANALYSIS; UPREGULATION; WESTERN BLOTTING; 129 MOUSE; AGING; ANIMAL; C57BL MOUSE; DEFICIENCY; KNOCKOUT MOUSE; METABOLISM; NERVE CELL; PATHOLOGY; PHYSIOLOGY; TRANSGENIC MOUSE;

AGING; ANIMALS; CELL SURVIVAL; CEREBRAL CORTEX; FEMALE; MALE; MICE; MICE, 129 STRAIN; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; NEURONS; PRESENILIN-1; PRESENILIN-2;

EID: 84911879080     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3261-14.2014     Document Type: Article

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